No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
203 |
4. Check minimum number of eventsNone |
203 |
5. Include endpointsNone |
203 |
6. Filter based on genotype QC (FinnGen only) |
203 |
Control definitions (FinnGen only)
- Control exclude
- RHEUMA_CHRYSTAL
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other/unspecified crystal arthropathies
based on the number of shared cases.
Similar with more cases:
- Other crystal arthropathies
- Crystal arthropathies, rheuma endpoint
- Polyarthropathies
- Finngen Rheumatological endpoints
- Arthropathies
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1547 | 864 | 670 |
| Only index persons | 1294 | 716 | 578 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 73.60 | 75.80 | 70.78 |
| Only index persons | 72.74 | 74.85 | 70.12 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 203 | 104 | 99 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | 69.74 | 68.37 | 71.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 178
- Matched controls
- 1778
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M11.9
ICD-10 Finland
Crystal arthropathy, unspecified
+∞
106.2
91
*
M11.8
ICD-10 Finland
Other specified crystal arthropathies
+∞
95.7
83
*
M13.9
ICD-10 Finland
Arthritis, unspecified
11.2
29.1
59
75
M11.2
ICD-10 Finland
Other chondrocalcinosis
112.0
19.0
20
*
N02AX02
ATC
tramadol; systemic, rectal
4.3
18.8
117
550
M10.9
ICD-10 Finland
Gout, unspecified
7.4
15.7
39
65
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
5.2
14.5
49
121
M17.1
ICD-10 Finland
Other primary gonarthrosis
3.7
13.6
74
286
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
6.7
13.3
35
63
H02AB06
ATC
prednisolone; systemic
3.3
13.0
116
642
M00.9
ICD-10 Finland
Pyogenic arthritis, unspecified
18.0
11.9
18
11
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
3.7
10.3
49
164
M79.6
ICD-10 Finland
Pain in limb
2.8
9.7
85
434
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
9.3
105
619
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.9
9.2
40
124
L15
ICPC
Knee symptom/complaint
3.1
8.4
55
227
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
3.8
8.3
37
116
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
7.7
7.7
17
24
N02AJ06
ATC
codeine and paracetamol; systemic
2.5
7.7
80
437
J01FF01
ATC
clindamycin; systemic
2.6
7.3
65
322
UKC02
NOMESCO Finland
Cystoscopy
2.9
7.2
47
195
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
3.6
7.1
33
107
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.3
7.0
38
137
X59
ICD-10 Finland
Exposure to unspecified factor
2.8
6.9
50
218
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.4
6.7
32
107
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
15.0
6.5
10
7
N03AX16
ATC
pregabalin; oral
2.5
6.3
56
273
J01DB01
ATC
cefalexin; oral
2.7
6.3
149
1174
A46
ICD-10 Finland
Erysipelas
2.9
6.2
41
167
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.8
6.1
25
73
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
5.1
6.1
18
38
SPAT1211
SPAT
Application of soft bandage
3.6
6.1
27
85
B01AA03
ATC
warfarin; systemic
2.4
6.1
59
304
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.8
6.0
40
165
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.6
6.0
26
80
Mortality – FinRegistry
↥Association
Association between endpoint CHRYSTAL_NOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRYSTAL_NOS | 1.612 [1.3, 2.0] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.049 |
During the follow-up period (1.1.1998 — 31.12.2019), 301 out of 641 females with CHRYSTAL_NOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRYSTAL_NOS | 1.755 [1.31, 2.36] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 218 out of 482 males with CHRYSTAL_NOS died.
Mortality risk
Mortality risk for people of age
years, who have CHRYSTAL_NOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.143% | 0.325% |
| 5 | 0.84% | 1.923% |
| 10 | 2.169% | 4.736% |
| 15 | 4.007% | 8.626% |
| 20 | 7.146% | 14.061% |
Relationships between endpoints
↥Index endpoint: CHRYSTAL_NOS – Other/unspecified crystal arthropathies
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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