No definition available.
Other disorders of electrolyte and fluid balance, not elsewhere classified
EFO MESH Endpoint Browser PheWeb
E4_FLUIDELECTRONAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
315 |
4. Check minimum number of eventsNone |
315 |
5. Include endpointsNone |
315 |
6. Filter based on genotype QC (FinnGen only) |
315 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E87
- Name in latin
- Aliae perturbationes aequilibrii electrolytici et humoralis
Similar endpoints
↥List of similar endpoints to
Other disorders of electrolyte and fluid balance, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other disorders of fluid, electrolyte and acid-base balance
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4640 | 3017 | 1556 |
| Only index persons | 2688 | 1786 | 902 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.09 | 0.04 |
| Only index persons | 0.06 | 0.07 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 67.70 | 70.72 | 61.89 |
| Only index persons | 65.00 | 66.77 | 61.50 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 315 | 189 | 126 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | 61.26 | 59.22 | 64.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 279
- Matched controls
- 2789
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E87.8
ICD-10 Finland
Other disorders of electrolyte and fluid balance, not elsewhere classified
+∞
205.5
171
*
2768A
ICD-9 Finland
Disorders of fluid, electrolyte and acid-base balance, Hypopotassaemia[HYPOKALAEMIA]
+∞
115.9
103
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
140.4
70.8
73
7
E87.6
ICD-10 Finland
Hypokalaemia
75.1
35.0
39
6
A12BA01
ATC
potassium chloride; oral
7.6
21.7
53
83
C03DA01
ATC
spironolactone; oral
5.5
21.7
71
164
E86
ICD-10 Finland
Volume depletion
95.8
16.8
18
*
4019X
ICD-9 Finland
Essential hypertension, Unspecified
8.6
15.6
34
44
205
Kela drug reimbursment
Chronic hypertension
2.9
14.8
125
611
R53
ICD-10 Finland
Malaise and fatigue
3.1
13.9
89
362
C03CA01
ATC
furosemide; systemic
2.7
13.5
128
664
E87.5
ICD-10 Finland
Hyperkalaemia
30.0
13.1
17
6
R11
ICD-10 Finland
Nausea and vomiting
4.5
11.8
43
109
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
10.8
97
476
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
3.9
10.6
45
131
E87.0
ICD-10 Finland
Hyperosmolality and hypernatraemia
+∞
10.5
10
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
6.2
10.3
27
47
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.1
10.2
62
238
N17.9
ICD-10 Finland
Acute renal failure, unspecified
7.0
10.0
24
37
N05BA01
ATC
diazepam; systemic, rectal
3.2
9.6
54
196
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.7
9.3
73
326
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.9
9.2
60
241
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.1
9.1
54
202
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.8
9.0
64
269
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
7.0
8.8
21
32
G40.9
ICD-10 Finland
Epilepsy, unspecified
6.5
8.8
22
36
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
8.7
94
496
H02AB09
ATC
hydrocortisone; systemic
13.3
8.5
14
11
F05.9
ICD-10 Finland
Delirium, unspecified
13.3
8.5
14
11
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.5
8.4
29
70
3071A
ICD-9 Finland
Special symptoms or syndromes not elsewhere classified, Anorexia nervosa
+∞
8.4
8
*
AA1AD
NOMESCO Finland
CT of head and brain
2.4
8.3
81
406
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
12.2
8.2
14
12
N03AX16
ATC
pregabalin; oral
2.4
8.1
74
359
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.6
8.0
27
64
C02EA02
ATC
NA
4.1
8.0
30
79
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
9.8
7.9
15
16
N06AX11
ATC
mirtazapine; oral
2.2
7.7
94
522
N19
ICD-10 Finland
Unspecified kidney failure
6.1
7.7
20
35
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
9.2
7.6
15
17
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.1
7.5
42
151
E87.3
ICD-10 Finland
Alkalosis
+∞
7.3
7
*
E87.2
ICD-10 Finland
Acidosis
+∞
7.3
7
*
K59.1
ICD-10 Finland
Functional diarrhoea
4.6
7.2
24
56
C07AB07
ATC
bisoprolol; oral
2.0
7.2
142
951
F10.24
ICD-10 Finland
Alcohol depence active use
20.6
7.2
10
5
C08CA01
ATC
amlodipine; oral
2.0
7.0
112
689
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
6.4
6.9
17
28
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
6.8
99
584
I10
ICD-10 Finland
Essential (primary) hypertension
1.9
6.8
170
1239
D64.9
ICD-10 Finland
Anaemia, unspecified
2.9
6.8
40
150
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
17.2
6.8
10
6
F50.9
ICD-10 Finland
Eating disorder, unspecified
17.2
6.8
10
6
N05AH04
ATC
quetiapine; oral
2.7
6.7
48
202
A10BH01
ATC
sitagliptin; oral
3.1
6.6
35
122
SPAT1211
SPAT
Application of soft bandage
3.1
6.6
35
122
A06AD11
ATC
lactulose; oral
2.4
6.6
60
288
N05BA04
ATC
oxazepam; oral
2.2
6.5
79
431
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
6.5
126
831
N03AX14
ATC
levetiracetam; systemic
6.8
6.4
15
23
124
Kela drug reimbursment
Inborn metabolic disorders
+∞
6.3
6
*
E83.51
ICD-10 Finland
Hypocalcemia
+∞
6.3
6
*
E87
ICD-10 Finland
Other disorders of fluid, electrolyte and acid-base balance
+∞
6.3
6
*
2768X
ICD-9 Finland
Disorders of fluid, electrolyte and acid-base balance, Hypopotassaemia[NESTE-, ELEKTROLYYTTI- JA HAPPOEMÄSTASAP MUUT HÄIR]
+∞
6.3
6
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.0
6.2
36
133
R42
ICD-10 Finland
Dizziness and giddiness
2.1
6.2
74
402
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.4
6.1
53
249
N03AG01
ATC
valproic acid; systemic, rectal
4.1
6.0
22
57
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
83
193
5.48
35.29
7.6
3.0
3.1
2.3
mmol/l
0.77
72
155
62
168
4.35
21.25
7.5
2.4
4.1
4.3
kpa
0.49
62
161
60
170
4.12
19.29
2.4
1.4
—
—
—
0
0
51
132
4.42
18.44
4.5
3.4
3.2
1.9
mmol/l
0.75
34
101
126
585
2.92
18.28
2.8
2.2
3.0
3.3
mg/l
1.06
116
485
35
67
5.75
17.94
1.7
1.1
—
—
—
0
0
56
165
3.91
16.96
7.1
4.4
11.1
10.5
mmol/l
0.20
56
153
29
54
5.81
15.25
4.2
3.1
8.4
8.0
kpa
0.73
29
48
192
1183
2.60
15.02
13.3
5.6
1.2
1.2
mmol/l
1.70
169
983
76
302
3.00
14.20
2.6
1.9
21.6
21.7
%
0.01
68
255
133
712
2.50
13.74
4.2
2.3
56.5
55.7
u/l
0.08
127
648
83
357
2.80
13.34
2.5
1.9
11.8
12.8
umol/l
0.66
76
325
205
1356
2.47
12.98
10.4
4.3
7.1
6.7
mmol/l
1.73
199
1266
49
165
3.33
12.00
3.4
2.5
96.9
83.4
ng/l
0.38
43
140
173
1091
2.30
11.81
14.2
4.9
1.2
1.2
mmol/l
2.38
165
973
64
263
2.80
11.06
11.5
7.4
2.4
1.3
mmol/l
0.81
53
202
55
211
2.95
10.77
2.3
1.8
1.8
1.4
%
2.74
48
182
160
1017
2.17
10.24
7.7
3.9
33.5
35.0
g/l
2.60
150
934
81
391
2.44
10.03
2.2
1.7
—
—
—
0
0
149
929
2.15
9.94
3.4
2.4
170.7
127.8
ug/l
0.96
144
819
148
923
2.14
9.84
3.0
2.1
76.6
79.1
nmol/l
0.47
135
794
145
927
2.05
8.74
6.2
3.6
28.0
38.7
ng/l
1.12
118
673
176
1220
2.00
8.32
8.8
5.6
10.7
11.5
umol/l
0.48
171
1143
10
11
9.36
8.13
1.3
1.5
—
—
—
0
0
46
187
2.71
8.02
1.6
2.0
65.6
67.2
g/l
0.68
46
169
33
112
3.17
7.92
10.8
5.1
25.0
25.0
mmol/l
0.01
33
112
102
595
2.06
7.72
1.8
1.5
20.9
21.3
nmol/l
0.11
93
484
48
204
2.60
7.66
2.5
2.4
0.2
0.2
g/l
0.25
41
188
133
856
1.96
7.60
4.6
2.9
—
—
—
0
0
19
45
4.43
7.58
3.4
2.1
16.2
15.4
%
0.33
13
17
184
1322
1.94
7.55
12.3
8.3
4.1
4.0
e9/l
0.27
168
1165
23
66
3.68
7.13
1.4
1.3
227.8
297.1
ug/g
0.99
16
41
30
105
3.05
6.84
11.2
2.0
0.6
0.7
%
0.15
30
100
83
472
2.03
6.61
1.4
1.2
0.7
1.4
u/ml
0.82
26
123
142
983
1.81
6.13
2.2
2.0
99.6
95.8
pmol/l
0.39
85
479
108
690
1.86
6.03
4.1
3.5
21.2
6.3
mg/mmol
1.15
69
419
224
1795
1.86
5.77
11.8
6.8
85.4
80.4
u/l
0.63
213
1655
113
755
1.77
5.33
3.8
2.9
3485.3
1442.3
ng/l
1.30
104
631
48
240
2.18
5.30
3.1
2.4
7.7
8.3
umol/l
0.09
36
206
101
660
1.78
5.11
4.2
2.8
0.4
0.4
e6/l
0.12
86
483
18
55
3.41
5.11
1.4
1.3
—
—
—
0
0
85
529
1.83
5.04
2.0
1.8
1313.7
1188.9
nmol/l
0.51
73
385
16
46
3.61
4.96
2.1
2.8
141.1
118.3
ug/min
0.09
11
26
51
268
2.08
4.95
2.4
1.7
—
—
—
0
0
200
1593
1.70
4.80
7.9
4.5
302.7
3920.1
e6/l
—
6
28
23
85
2.84
4.79
5.5
3.7
26.7
24.7
mmol/l
0.76
23
85
90
583
1.76
4.63
3.7
2.5
362.0
6258.1
umol/l
2.59
81
491
22
81
2.84
4.62
1.6
1.5
3.9
3.6
g/l
0.34
17
59
22
81
2.84
4.62
1.6
1.5
—
—
—
0
0
22
81
2.84
4.62
1.6
1.5
8.2
7.5
g/l
0.85
17
61
9
11
8.38
4.59
1.3
1.5
—
—
—
0
0
10
21
4.89
4.56
1.3
2.0
—
—
—
0
0
155
1167
1.65
4.53
6.6
3.7
0.0
0.0
estimate
0.00
37
232
84
538
1.77
4.48
2.0
1.7
466.8
451.9
pmol/l
0.17
75
427
155
1172
1.63
4.42
8.1
5.1
0.0
0.0
estimate
0.00
36
225
49
266
2.00
4.35
2.4
1.6
—
—
—
0
0
31
141
2.33
4.28
1.8
1.4
—
—
—
0
0
29
130
2.36
4.14
18.1
6.7
92.1
93.9
%
0.40
29
130
74
467
1.76
4.12
2.0
1.6
1.2
1.1
mg/l
0.16
60
363
13
37
3.62
4.09
3.1
1.5
1.6
1.6
mmol/l
0.00
13
37
54
310
1.90
4.08
20.0
25.6
1.4
1.4
inr
0.00
11
48
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
16
53
3.13
4.02
3.3
2.4
0.5
0.3
u/ml
—
10
33
115
825
1.62
3.95
3.6
3.1
2.3
2.4
mmol/l
0.20
101
707
154
1187
1.58
3.90
6.7
3.8
0.0
0.0
estimate
0.00
33
226
8
13
6.28
3.52
1.0
1.0
—
—
—
0
0
61
382
1.74
3.46
3.6
2.6
0.6
1.2
e6/l
1.98
42
215
11
32
3.53
3.36
1.1
1.3
—
—
—
0
0
22
99
2.31
3.14
1.8
2.0
—
—
—
0
0
175
1432
1.50
3.12
4.9
2.9
82.5
48.4
u/l
2.12
164
1315
155
1245
1.48
2.98
3.3
2.8
—
—
—
0
0
6
9
6.77
2.88
3.0
2.4
—
—
—
0
0
65
435
1.62
2.87
5.9
3.5
111.2
195.8
ng/l
0.52
55
348
12
42
2.93
2.78
1.7
1.1
—
—
—
0
0
77
545
1.55
2.67
3.7
2.3
—
—
—
0
0
27
143
1.97
2.60
1.9
1.6
—
—
—
0
0
8
20
4.08
2.58
1.4
2.0
—
—
—
0
0
5
160
0.30
2.49
2.0
1.8
—
—
—
0
0
131
1051
1.42
2.39
6.1
4.0
—
—
—
0
0
5
8
6.33
2.38
1.0
1.1
—
—
—
0
0
119
940
1.43
2.36
7.3
4.0
—
—
—
0
0
15
65
2.37
2.35
1.5
1.5
0.0
1.6
g/l
1.85
15
55
41
257
1.68
2.33
4.7
3.4
—
—
—
0
0
14
59
2.44
2.32
1.6
1.5
0.0
0.0
g/l
0.00
14
52
10
35
2.92
2.32
2.4
1.4
—
—
—
0
0
15
66
2.34
2.28
1.7
1.5
38.4
37.3
g/l
0.26
15
56
5
9
5.62
2.22
3.0
2.4
—
—
—
0
0
5
9
5.62
2.22
1.2
1.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
9
5.62
2.22
1.0
1.1
—
—
—
0
0
5
9
5.62
2.22
3.0
2.4
—
—
—
0
0
7
19
3.74
2.16
2.3
2.2
—
—
—
0
0
7
19
3.74
2.16
1.0
1.1
—
—
—
0
0
6
14
4.35
2.16
2.3
1.4
—
—
—
0
0
203
1776
1.40
2.16
5.4
3.9
15.6
15.0
pmol/l
2.15
187
1567
13
55
2.42
2.15
2.7
1.6
—
—
—
0
0
88
672
1.43
2.07
8.5
4.0
0.0
0.0
estimate
0.00
35
223
51
350
1.55
2.02
3.8
2.7
1.7
2.1
e6/l
0.22
31
184
13
58
2.29
1.93
1.6
1.6
0.0
0.0
g/l
0.00
13
52
12
52
2.36
1.90
2.8
1.6
—
—
—
0
0
18
93
1.99
1.89
1.7
1.8
—
—
—
0
0
16
79
2.08
1.89
2.0
1.2
—
—
—
0
0
9
34
2.69
1.88
1.3
1.4
—
—
—
0
0
13
59
2.26
1.87
1.6
1.5
0.0
0.0
g/l
0.00
13
52
6
17
3.58
1.84
4.8
2.2
—
—
—
0
0
16
80
2.05
1.83
2.0
1.2
—
—
—
0
0
9
35
2.62
1.81
1.4
1.4
—
—
—
0
0
9
35
2.62
1.81
1.4
1.4
—
—
—
0
0
9
35
2.62
1.81
1.4
1.4
—
—
—
0
0
9
35
2.62
1.81
1.4
1.4
—
—
—
0
0
13
60
2.22
1.80
1.8
1.6
—
—
—
0
0
11
47
2.39
1.79
1.0
1.2
—
—
—
0
0
10
41
2.49
1.77
2.7
1.7
—
—
—
0
0
9
36
2.54
1.75
1.4
1.4
—
—
—
0
0
5
14
3.61
1.62
1.4
1.0
—
—
—
0
0
63
474
1.41
1.59
3.7
3.0
2.5
2.5
mmol/l
0.16
53
418
6
20
3.04
1.59
2.5
2.0
—
—
—
0
0
6
20
3.04
1.59
2.5
2.0
—
—
—
0
0
6
20
3.04
1.59
1.0
1.2
—
—
—
0
0
6
20
3.04
1.59
2.5
2.0
—
—
—
0
0
7
27
2.63
1.52
2.6
1.3
—
—
—
0
0
15
79
1.94
1.52
1.8
1.7
—
—
—
0
0
14
72
1.99
1.51
3.0
1.5
—
—
—
0
0
235
2160
1.35
1.50
6.2
4.6
1.8
2.0
mu/l
0.90
223
1916
7
28
2.53
1.46
1.7
1.4
—
—
—
0
0
196
1763
1.30
1.42
6.5
4.0
17.1
13.0
mm/h
2.85
188
1606
9
41
2.23
1.38
1.0
1.3
—
17.0
—
0
5
6
24
2.53
1.31
1.0
2.5
3.8
3.6
nmol/l
—
6
24
67
527
1.34
1.30
7.5
4.0
1.0
1.0
kg/l
0.26
15
69
5
18
2.81
1.29
2.4
1.2
—
—
—
0
0
5
19
2.66
1.22
1.0
1.2
—
—
—
0
0
7
30
2.36
1.13
3.6
1.5
—
—
—
0
0
248
2332
1.30
1.10
32.3
13.7
26.1
24.3
mg/l
0.34
228
1832
5
21
2.40
1.09
1.2
1.0
—
—
—
0
0
49
378
1.35
1.09
1.3
1.3
36.9
10.6
u/ml
0.54
15
140
7
33
2.15
1.06
1.0
1.3
—
—
—
0
0
26
180
1.48
1.04
2.9
2.9
64.3
60.7
ml/min/173m2
0.21
11
64
7
34
2.08
1.03
4.1
1.5
—
—
—
0
0
257
2438
1.29
0.99
43.2
15.8
137.0
139.8
mmol/l
17.19
251
2363
19
124
1.57
0.99
2.1
1.3
—
—
—
0
0
49
386
1.32
0.96
1.3
1.3
21.1
40.7
iu/ml
1.11
16
123
7
37
1.91
0.94
4.6
1.5
—
—
—
0
0
257
2445
1.28
0.92
42.1
15.9
4.0
4.0
mmol/l
0.60
251
2366
6
31
1.95
0.85
4.2
1.5
—
—
—
0
0
10
59
1.72
0.76
1.0
1.1
—
15.5
—
0
7
5
25
2.02
0.73
2.6
3.6
—
—
—
0
0
11
69
1.62
0.69
1.4
1.3
—
—
—
0
0
5
27
1.87
0.68
1.0
1.1
—
—
—
0
0
5
27
1.87
0.68
1.0
1.3
—
—
—
0
0
20
145
1.41
0.67
1.9
1.7
—
—
—
0
0
12
78
1.56
0.66
2.7
2.9
—
—
—
0
0
5
28
1.80
0.66
1.0
1.1
—
—
—
0
0
216
2259
0.86
0.57
4.5
4.2
1.5
1.5
mmol/l
0.49
201
2031
8
54
1.49
0.57
2.0
1.8
—
—
—
0
0
224
2335
0.86
0.56
5.2
4.8
2.5
2.7
mmol/l
3.19
212
2093
20
154
1.32
0.50
2.2
1.9
—
—
—
0
0
7
46
1.53
0.48
1.1
1.5
—
—
—
0
0
7
50
1.41
0.45
2.0
1.3
—
—
—
0
0
7
50
1.41
0.45
2.0
1.3
—
—
—
0
0
33
391
0.83
0.44
2.9
3.1
0.7
0.7
ug/l
0.23
26
255
32
270
1.21
0.40
2.7
4.1
130.3
51.7
ug/l
0.26
27
228
10
71
1.42
0.39
1.8
1.7
—
—
—
0
0
9
66
1.37
0.38
1.4
1.3
—
—
—
0
0
9
67
1.35
0.38
2.0
1.9
—
—
—
0
0
5
37
1.36
0.37
1.0
1.8
—
—
—
0
0
27
318
0.83
0.35
21.5
6.7
—
—
—
0
0
6
45
1.34
0.34
1.0
1.3
—
—
—
0
0
221
2276
0.90
0.33
4.5
4.3
4.4
4.7
mmol/l
2.39
208
2063
17
139
1.24
0.29
7.5
3.3
121.3
51.7
u/ml
0.59
17
133
28
321
0.86
0.28
1.4
1.4
—
—
—
0
0
50
542
0.91
0.22
5.8
4.4
22.4
21.8
%
0.10
28
270
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
6
50
1.20
0.20
1.0
1.1
—
—
—
0
0
221
2164
1.07
0.19
7.5
5.6
41.8
40.0
mmol/mol
1.74
214
1973
7
61
1.15
0.17
1.7
1.5
275.9
261.2
pmol/l
—
7
61
64
677
0.93
0.17
5.3
4.8
4.6
4.4
ug/l
0.03
58
593
8
71
1.13
0.16
2.0
1.7
—
—
—
0
0
11
130
0.84
0.16
1.0
1.2
189.3
147.4
iu/ml
—
5
54
13
113
1.16
0.13
1.3
1.0
—
—
—
0
0
63
603
1.06
0.11
1.7
1.6
1.5
1.3
mmol/l
0.75
54
486
251
2487
1.05
0.09
17.0
9.9
25.1
24.0
u/l
0.55
243
2377
227
2294
0.96
0.08
5.3
4.6
6.4
6.0
mmol/l
2.63
203
2045
5
60
0.83
0.08
2.0
1.3
—
—
—
0
0
222
2198
1.03
0.07
29.5
12.9
75.1
76.5
ml/min/173m2
0.36
194
1804
217
2188
0.97
0.05
4.0
3.8
1.4
1.2
mmol/l
1.30
202
1958
33
317
1.05
0.05
1.7
1.6
—
—
—
0
0
205
2060
0.99
0.02
29.6
14.4
37.3
39.2
%
1.67
125
1388
32
322
0.99
0.00
4.1
4.2
36.7
33.2
%
1.35
27
204
6
59
1.02
0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
5
59
0.85
0.00
1.2
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.8
—
—
—
0
0
0
8
0.00
0.00
0.0
2.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_FLUIDELECTRONAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_FLUIDELECTRONAS | 2.068 [1.65, 2.59] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.524 |
During the follow-up period (1.1.1998 — 31.12.2019), 438 out of 950 females with E4_FLUIDELECTRONAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_FLUIDELECTRONAS | 5.006 [2.97, 8.43] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 272 out of 534 males with E4_FLUIDELECTRONAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_FLUIDELECTRONAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.155% | 0.87% |
| 5 | 1.318% | 5.3% |
| 10 | 3.19% | 13.38% |
| 15 | 6.384% | 24.389% |
| 20 | 10.98% | 38.141% |
Relationships between endpoints
↥Index endpoint: E4_FLUIDELECTRONAS – Other disorders of electrolyte and fluid balance, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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