No definition available.
Other disorders of electrolyte and fluid balance, not elsewhere classified
EFO MESH Endpoint Browser PheWeb
E4_FLUIDELECTRONAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
343 |
4. Check minimum number of eventsNone |
343 |
5. Include endpointsNone |
343 |
6. Filter based on genotype QC (FinnGen only) |
334 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E87
- Name in latin
- Aliae perturbationes aequilibrii electrolytici et humoralis
Similar endpoints
↥List of similar endpoints to
Other disorders of electrolyte and fluid balance, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other disorders of fluid, electrolyte and acid-base balance
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4640 | 3017 | 1556 |
| Only index persons | 2688 | 1786 | 902 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.09 | 0.04 |
| Only index persons | 0.06 | 0.07 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 67.70 | 70.72 | 61.89 |
| Only index persons | 65.00 | 66.77 | 61.50 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 334 | 197 | 137 |
| Unadjusted period prevalence (%) | 0.07 | 0.07 | 0.06 |
| Median age at first event (years) | 63.37 | 61.61 | 65.91 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 343
- Matched controls
- 3430
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E87.8
ICD-10 Finland
Other disorders of electrolyte and fluid balance, not elsewhere classified
7244.9
276.3
228
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
76.9
180.5
99
18
2768A
ICD-9 Finland
Disorders of fluid, electrolyte and acid-base balance, Hypopotassaemia[HYPOKALAEMIA]
+∞
122.4
110
*
E87.6
ICD-10 Finland
Hypokalaemia
70.8
47.9
54
9
C03DA01
ATC
spironolactone; oral
4.7
32.0
91
245
A12BA01
ATC
potassium chloride; oral
5.9
28.0
55
107
E87.5
ICD-10 Finland
Hyperkalaemia
48.7
22.7
27
6
205
Kela drug reimbursment
Chronic hypertension
3.1
22.5
150
692
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.3
20.6
100
381
4019X
ICD-9 Finland
Essential hypertension, Unspecified
6.4
20.5
36
62
E86
ICD-10 Finland
Volume depletion
51.4
20.4
24
5
R11
ICD-10 Finland
Nausea and vomiting
4.4
20.2
56
145
G40.9
ICD-10 Finland
Epilepsy, unspecified
7.4
19.9
30
44
N17.9
ICD-10 Finland
Acute renal failure, unspecified
7.4
19.9
30
44
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
18.6
133
625
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
5.0
17.3
40
89
R53
ICD-10 Finland
Malaise and fatigue
2.8
17.1
118
540
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
5.9
15.5
29
53
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.0
15.5
86
348
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.0
15.3
80
313
C03CA01
ATC
furosemide; systemic
2.4
14.2
154
862
AA1AD
NOMESCO Finland
CT of head and brain
2.5
14.1
117
579
K59.1
ICD-10 Finland
Functional diarrhoea
4.4
13.5
36
90
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.6
13.4
33
77
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
13.2
75
306
E87.0
ICD-10 Finland
Hyperosmolality and hypernatraemia
+∞
12.6
12
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.0
12.3
37
101
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.7
12.1
76
326
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
12.0
122
654
N30.0
ICD-10 Finland
Acute cystitis
2.8
11.9
72
302
N03AX16
ATC
[U] pregabalin
2.5
11.7
96
467
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
11.4
177
1123
N05BA01
ATC
diazepam; systemic, rectal
2.8
11.1
64
261
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
2.8
10.5
61
250
C02EA02, ,
ATC
3.7
10.5
34
98
N19
ICD-10 Finland
Unspecified kidney failure
5.2
10.4
22
45
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.2
10.3
28
71
D64.9
ICD-10 Finland
Anaemia, unspecified
2.9
10.2
54
210
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
7.9
9.6
21
28
F50.9
ICD-10 Finland
Eating disorder, unspecified
31.0
9.5
12
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.0
9.5
45
165
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.6
9.4
32
95
E87
ICD-10 Finland
Other disorders of fluid, electrolyte and acid-base balance
+∞
9.4
9
*
E87.3
ICD-10 Finland
Alkalosis
+∞
9.4
9
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.1
9.4
136
825
R42
ICD-10 Finland
Dizziness and giddiness
2.2
9.3
95
504
N05AH04
ATC
quetiapine; oral
2.5
9.2
68
313
N30.9
ICD-10 Finland
Cystitis, unspecified
3.4
9.2
34
107
N05CD07
ATC
temazepam; oral
2.5
9.2
63
280
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.9
9.1
44
163
N03AX14
ATC
levetiracetam; systemic
7.8
9.1
20
27
N03AG01
ATC
valproic acid; systemic, rectal
3.7
9.0
29
83
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.7
9.0
51
206
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
24.8
9.0
12
5
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.3
8.9
82
415
C08CA01
ATC
amlodipine; oral
2.0
8.9
149
950
C08CA02
ATC
felodipine; oral
2.8
8.8
47
184
R4190
NOMESCO Finland
Nutritional therapy
6.7
8.6
21
33
N03AF02
ATC
oxcarbazepine; oral
6.7
8.6
21
33
A06AD11
ATC
lactulose; oral
2.3
8.5
73
358
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
8.5
127
774
E87.2
ICD-10 Finland
Acidosis
92.2
8.5
9
*
N05BA04
ATC
oxazepam; oral
2.1
8.4
105
599
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.8
8.4
45
176
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.7
8.2
19
42
P15
ICPC
Chronic alcohol abuse
7.1
8.2
19
28
J01MA02
ATC
ciprofloxacin; systemic
1.9
8.1
144
930
N05AH03
ATC
olanzapine; systemic
3.6
8.0
27
80
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.2
8.0
32
106
N06AX11
ATC
mirtazapine; oral
2.0
7.9
125
774
UJF32
NOMESCO Finland
Coloscopy
2.0
7.8
102
589
F05.9
ICD-10 Finland
Delirium, unspecified
6.6
7.8
19
30
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
7.8
51
221
A10BH01
ATC
sitagliptin; oral
2.7
7.8
43
171
A10AE04
ATC
insulin glargine; parenteral
2.9
7.6
38
143
JN3AD
NOMESCO Finland
Abdominal CT examination
2.7
7.5
44
180
I10
ICD-10 Finland
Essential (primary) hypertension
1.9
7.5
220
1657
N05AA02
ATC
levomepromazine; systemic
3.9
7.5
22
59
3071A
ICD-9 Finland
Special symptoms or syndromes not elsewhere classified, Anorexia nervosa
81.8
7.4
8
*
K59.09
ICD-10 Finland
Constipation, unspecified
3.0
7.3
33
117
124
Kela drug reimbursment
Inborn metabolic disorders
+∞
7.3
7
*
C07AB07
ATC
bisoprolol; oral
1.9
7.2
185
1328
101
Kela drug reimbursment
Anterior pituitary hypofunction
30.7
7.2
9
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.9
7.2
138
906
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
4.5
7.0
17
39
7865A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Chest pain
6.1
7.0
18
31
N06AB04
ATC
citalopram; systemic
2.1
7.0
81
446
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
7.8
7.0
15
20
N03AF01
ATC
carbamazepine; oral, rectal
3.1
6.9
30
104
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
4.3
6.9
18
44
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
11.3
6.8
12
11
N02AC04
ATC
dextropropoxyphene; oral
3.6
6.8
23
68
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.3
6.7
25
79
SPAT1234
SPAT
Support of social functional capacity
3.1
6.7
28
95
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
23.0
6.7
9
*
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
8.1
6.7
14
18
N05AX08
ATC
risperidone; systemic
2.5
6.5
44
193
N06AA09
ATC
amitriptyline; systemic
2.6
6.5
40
168
E83.51
ICD-10 Finland
Hypocalcemia
71.1
6.4
7
*
TPH07
NOMESCO Finland
Cathetrisation of artery
2.5
6.4
43
188
R50.9
ICD-10 Finland
Fever, unspecified
2.2
6.4
55
269
C09BA02
ATC
enalapril and diuretics; systemic
2.7
6.3
36
145
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
11.3
6.3
11
10
G41.9
ICD-10 Finland
Status epilepticus, unspecified
18.4
6.3
9
5
7803A
ICD-9 Finland
General symptoms, Convulsions
18.4
6.3
9
5
2761A
ICD-9 Finland
Disorders of fluid, electrolyte and acid-base balance, Hyposmolality and/or hyponatraemia
+∞
6.3
6
*
2768X
ICD-9 Finland
Disorders of fluid, electrolyte and acid-base balance, Hypopotassaemia[NESTE-, ELEKTROLYYTTI- JA HAPPOEMÄSTASAP MUUT HÄIR]
+∞
6.3
6
*
E83.4
ICD-10 Finland
Disorders of magnesium metabolism
+∞
6.3
6
*
C02AC05
ATC
moxonidine; oral
3.7
6.3
20
57
N05CF01
ATC
zopiclone; oral
1.8
6.3
127
840
N02BF02
ATC
pregabalin; oral
3.2
6.2
25
83
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
7.9
6.2
13
17
M01AH02
ATC
rofecoxib; oral
2.2
6.2
55
273
J01FF01
ATC
clindamycin; systemic
1.9
6.1
95
577
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.5
6.1
41
180
H02AB09
ATC
hydrocortisone; systemic
6.2
6.1
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
42
22
21.62
54.47
1.5
1.0
266.19
283.60
mosm/kgh2o
3.91
31
15
94
218
5.56
40.18
7.1
2.9
2.92
2.35
mmol/l
0.50
82
180
84
199
5.27
34.70
2.3
1.8
407.85
374.44
nmol/l
0.62
79
181
94
300
3.94
25.91
17.9
5.2
99.07
104.44
mmol/l
6.40
94
300
71
190
4.45
24.78
7.0
2.4
4.13
4.33
kpa
0.42
71
182
59
144
4.74
23.04
4.1
3.3
3.62
1.88
mmol/l
1.09
39
115
65
177
4.30
22.05
2.4
1.5
—
—
—
0
0
65
177
4.30
22.05
6.6
4.4
10.36
10.56
mmol/l
0.07
65
163
141
645
3.01
21.22
2.9
2.1
2.85
3.30
mg/l
1.78
130
539
34
54
6.88
20.96
3.8
3.1
8.40
8.02
kpa
0.60
34
54
218
1286
2.91
20.03
14.8
5.6
1.20
1.22
mmol/l
2.73
193
1076
37
71
5.72
18.89
1.6
1.1
—
—
—
0
0
205
1224
2.68
17.51
15.6
15.4
1.34
1.29
inr
0.30
66
362
230
1473
2.70
16.72
12.2
4.3
7.09
6.67
mmol/l
1.99
225
1381
63
203
3.58
16.64
18.3
5.1
1.46
1.44
mmol/l
0.05
63
198
197
1187
2.55
16.00
15.6
4.9
1.19
1.21
mmol/l
3.39
188
1062
146
770
2.56
15.69
4.3
2.3
56.48
64.98
u/l
0.63
140
704
93
391
2.89
15.67
2.4
1.9
11.91
12.68
umol/l
0.42
87
360
196
1189
2.51
15.53
6.6
5.2
25.05
27.38
%
2.15
190
1098
194
1175
2.50
15.37
6.2
4.9
59.45
57.34
%
1.45
188
1085
83
331
2.99
15.36
2.5
1.9
22.43
21.54
%
0.21
75
278
171
1000
2.42
14.34
2.9
2.1
76.07
79.25
nmol/l
0.71
155
855
75
294
2.99
14.24
16.7
7.4
2.31
1.36
mmol/l
0.81
63
226
42
119
3.88
13.28
20.3
5.2
25.08
25.06
mmol/l
0.01
42
119
62
227
3.11
13.20
2.5
1.7
1.84
1.38
%
2.00
54
195
93
425
2.63
13.10
2.4
1.7
—
—
—
0
0
180
1107
2.32
13.08
7.8
3.9
33.58
35.01
g/l
2.51
170
1013
167
1015
2.26
12.25
3.4
2.4
172.30
131.82
ug/l
0.99
161
901
52
185
3.13
11.57
3.4
2.4
96.33
81.90
ng/l
0.44
46
155
152
913
2.19
11.22
4.9
3.0
—
—
—
0
0
118
642
2.28
11.09
1.9
1.5
21.18
21.13
nmol/l
0.01
108
525
162
1009
2.15
10.79
6.0
3.5
27.08
38.74
ng/l
1.40
133
734
197
1329
2.13
10.58
9.1
5.8
11.17
11.46
umol/l
0.14
191
1249
102
540
2.27
10.10
3.6
2.5
5.26
5.63
e6/l
0.14
97
479
207
1441
2.10
10.01
11.6
8.4
4.14
4.04
e9/l
0.31
184
1268
21
43
5.14
9.92
3.2
2.2
16.08
15.50
%
0.20
15
15
51
203
2.78
9.23
1.6
2.2
65.12
67.22
g/l
1.01
51
182
55
231
2.64
8.97
2.5
2.3
0.21
0.20
g/l
0.21
48
213
12
5
24.78
8.97
2.6
1.2
184.58
105.73
mmol/24h
—
12
5
162
1061
2.00
8.94
2.3
2.0
97.98
96.80
pmol/l
0.11
97
526
95
514
2.17
8.77
1.4
1.2
0.70
1.45
u/ml
0.89
28
127
25
66
4.01
8.68
1.4
1.3
238.39
291.92
ug/g
0.75
18
42
57
248
2.56
8.65
3.4
2.5
14.41
8.37
umol/l
0.39
44
212
116
693
2.02
8.15
4.7
2.9
0.40
0.42
e6/l
0.06
99
513
61
291
2.33
7.54
2.6
1.6
—
—
—
0
0
178
1252
1.88
7.53
6.6
3.8
0.00
0.00
estimate
-0.00
42
257
19
46
4.31
7.37
1.5
1.1
—
—
—
0
0
119
739
1.93
7.35
3.4
2.8
5.74
7.18
mmol/l
2.95
101
603
60
290
2.30
7.19
2.6
1.6
—
—
—
0
0
177
1256
1.85
7.16
8.4
5.0
0.00
0.00
estimate
-0.00
38
231
249
1971
1.96
7.11
12.0
6.8
85.39
79.65
u/l
0.88
238
1819
32
114
2.99
7.06
5.5
8.4
1.72
1.65
%
0.17
32
107
37
146
2.72
6.79
27.5
6.9
92.61
94.10
%
0.44
37
146
224
1733
1.84
6.62
8.2
4.5
3554.43
4635.26
e6/l
—
7
31
176
1272
1.79
6.49
6.7
3.8
0.00
0.00
estimate
-0.00
35
233
118
759
1.85
6.39
3.9
3.3
21.60
5.90
mg/mmol
1.42
76
455
73
404
2.03
6.16
4.0
2.6
0.64
1.15
e6/l
1.78
49
227
94
569
1.90
6.12
2.0
1.7
1302.88
1173.12
nmol/l
0.58
79
422
36
148
2.60
6.10
1.8
1.4
—
—
—
0
0
85
505
1.91
5.83
2.2
1.6
1.20
1.12
mg/l
0.09
69
391
20
60
3.48
5.81
1.5
1.2
—
—
—
0
0
124
833
1.77
5.69
3.8
2.9
3302.15
1375.04
ng/l
1.37
115
691
130
890
1.74
5.56
3.4
3.1
2.34
2.36
mmol/l
0.50
114
769
99
630
1.80
5.42
3.6
2.4
4277.49
7160.27
umol/l
0.29
90
532
11
14
8.08
5.38
1.3
1.4
—
—
—
0
0
24
87
2.89
5.16
1.5
1.4
9.97
11.20
g/l
0.73
24
74
25
94
2.79
5.03
1.5
1.4
—
—
—
0
0
25
94
2.79
5.03
1.5
1.4
7.89
7.48
g/l
0.59
25
82
25
94
2.79
5.03
1.5
1.4
3.70
3.46
g/l
0.51
25
82
35
156
2.38
5.02
2.3
1.5
—
—
—
0
0
91
586
1.75
4.72
2.0
1.8
452.20
448.95
pmol/l
0.03
80
470
10
14
7.32
4.68
1.3
1.4
—
—
—
0
0
176
1349
1.63
4.68
3.3
2.8
—
—
—
0
0
63
366
1.88
4.56
4.3
2.7
1.59
1.85
e6/l
0.18
38
190
77
479
1.78
4.47
6.4
3.5
94.86
212.28
ng/l
0.93
66
382
16
50
3.31
4.39
1.8
2.5
141.09
106.53
ug/min
0.15
11
29
196
1559
1.60
4.35
5.1
2.9
87.14
47.48
u/l
2.86
185
1432
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
18
61
3.06
4.35
3.1
2.3
0.45
0.34
u/ml
—
10
37
23
90
2.67
4.31
1.5
1.5
2.90
3.08
g/l
0.37
23
78
7
6
11.87
4.29
1.0
1.2
—
—
—
0
0
14
38
3.80
3.84
3.0
1.5
1.63
1.62
mmol/l
0.01
14
38
9
17
5.41
3.53
1.0
1.0
—
—
—
0
0
10
24
4.26
3.22
1.3
1.9
—
—
—
0
0
14
50
2.88
3.12
1.0
1.2
—
—
—
0
0
6
8
7.61
3.06
1.0
1.1
—
—
—
0
0
6
8
7.61
3.06
2.8
2.6
—
—
—
0
0
6
8
7.61
3.06
2.8
2.6
—
—
—
0
0
147
1157
1.47
3.06
3.9
2.5
—
—
—
0
0
86
609
1.55
2.95
4.0
2.3
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
9
6.76
2.88
1.0
1.1
—
—
—
0
0
18
77
2.41
2.87
1.6
1.5
39.16
36.88
g/l
0.78
18
65
45
272
1.75
2.86
4.7
3.5
—
—
—
0
0
23
110
2.17
2.86
1.8
1.9
—
—
—
0
0
17
71
2.47
2.85
1.5
1.5
0.00
0.00
g/l
-0.00
17
61
130
1011
1.46
2.83
7.4
4.0
—
—
—
0
0
18
78
2.38
2.79
1.4
1.5
0.04
1.95
g/l
1.69
18
65
224
1939
1.45
2.68
5.2
3.9
15.53
14.97
pmol/l
2.09
206
1706
11
35
3.21
2.67
1.1
1.3
—
—
—
0
0
18
80
2.32
2.65
1.9
1.2
—
—
—
0
0
18
81
2.29
2.58
1.9
1.2
—
—
—
0
0
13
50
2.66
2.56
5.5
2.7
4.85
4.86
kpa
0.01
13
50
8
21
3.87
2.48
1.0
1.0
—
—
—
0
0
12
45
2.73
2.47
1.0
1.3
—
17.02
—
0
5
6
12
5.07
2.41
3.0
3.1
—
—
—
0
0
262
2365
1.46
2.28
6.1
4.6
1.89
2.01
mu/l
0.77
248
2097
8
23
3.54
2.28
1.4
1.9
—
—
—
0
0
7
18
3.95
2.26
1.0
1.2
—
—
—
0
0
10
35
2.91
2.22
1.1
1.4
—
—
—
0
0
10
35
2.91
2.22
2.4
1.4
—
—
—
0
0
5
9
5.62
2.22
1.2
1.1
—
—
—
0
0
95
725
1.43
2.21
8.4
4.0
0.00
0.00
estimate
-0.00
37
227
71
513
1.48
2.19
3.6
3.0
2.45
2.46
mmol/l
0.05
60
448
6
14
4.34
2.16
2.2
2.1
—
—
—
0
0
15
68
2.26
2.14
1.5
1.5
0.00
0.00
g/l
-0.00
15
59
218
1919
1.37
2.10
6.3
4.0
17.24
12.96
mm/h
3.22
209
1745
10
37
2.75
2.08
1.3
1.3
—
—
—
0
0
6
163
0.36
2.07
2.2
1.8
—
—
—
0
0
7
20
3.55
2.06
2.3
2.2
—
—
—
0
0
10
38
2.68
2.02
1.4
1.3
—
—
—
0
0
10
38
2.68
2.02
1.4
1.3
—
—
—
0
0
10
38
2.68
2.02
1.4
1.3
—
—
—
0
0
10
38
2.68
2.02
1.4
1.3
—
—
—
0
0
15
70
2.20
2.01
1.5
1.5
0.00
0.00
g/l
-0.00
15
60
17
84
2.08
1.99
1.6
1.6
—
—
—
0
0
10
39
2.61
1.95
1.4
1.3
—
—
—
0
0
19
101
1.93
1.84
1.7
1.7
—
—
—
0
0
14
66
2.17
1.84
1.9
1.6
—
—
—
0
0
5
12
4.21
1.83
1.0
1.4
—
—
—
0
0
5
12
4.21
1.83
1.0
1.4
—
—
—
0
0
9
35
2.61
1.81
1.0
1.3
—
—
—
0
0
276
2551
1.42
1.81
33.3
13.6
25.69
24.51
mg/l
0.22
255
2009
8
29
2.80
1.80
2.6
1.4
—
—
—
0
0
8
29
2.80
1.80
2.6
1.4
—
—
—
0
0
13
61
2.18
1.74
2.7
1.5
—
—
—
0
0
22
126
1.80
1.72
2.0
1.3
—
—
—
0
0
5
13
3.89
1.72
1.0
1.0
—
—
—
0
0
6
19
3.19
1.67
2.5
1.3
76.00
80.00
umol/l
—
6
19
10
43
2.36
1.60
2.7
1.6
—
—
—
0
0
6
20
3.03
1.59
4.8
4.1
—
—
—
0
0
15
78
1.97
1.56
2.9
1.4
—
—
—
0
0
5
15
3.37
1.53
1.0
1.0
—
—
—
0
0
5
15
3.37
1.53
1.4
1.0
—
—
—
0
0
285
2671
1.40
1.52
45.8
15.8
136.82
139.78
mmol/l
20.33
279
2588
7
27
2.62
1.52
2.6
1.3
—
—
—
0
0
12
58
2.11
1.51
2.8
1.6
—
—
—
0
0
74
580
1.35
1.45
7.3
4.1
1.02
1.02
kg/l
0.47
16
78
5
16
3.15
1.44
2.2
2.0
—
—
—
0
0
6
22
2.76
1.44
2.5
2.0
—
—
—
0
0
6
22
2.76
1.44
2.5
2.0
—
—
—
0
0
6
22
2.76
1.44
2.5
2.0
—
—
—
0
0
6
22
2.76
1.44
1.0
1.1
—
—
—
0
0
23
142
1.66
1.42
1.1
1.4
—
49.35
—
0
10
285
2679
1.38
1.42
44.6
15.8
3.96
3.98
mmol/l
0.57
279
2591
9
41
2.23
1.38
2.4
1.6
—
—
—
0
0
9
41
2.23
1.38
2.4
1.6
—
—
—
0
0
5
19
2.65
1.22
2.4
1.2
—
—
—
0
0
29
198
1.51
1.21
2.9
2.9
64.25
61.74
ml/min/173m2
0.16
12
73
7
31
2.28
1.11
1.4
1.2
—
—
—
0
0
5
21
2.40
1.09
1.0
1.1
—
—
—
0
0
5
21
2.40
1.09
1.0
1.2
—
—
—
0
0
24
162
1.52
1.07
2.1
2.6
—
34.45
—
0
6
7
33
2.14
1.06
3.6
1.5
—
—
—
0
0
52
408
1.32
1.03
1.3
1.3
20.56
42.32
iu/ml
1.36
17
131
13
76
1.74
1.00
1.3
1.3
—
—
—
0
0
51
401
1.32
1.00
1.3
1.3
45.84
11.10
u/ml
0.77
16
145
5
23
2.19
0.98
1.2
1.0
—
—
—
0
0
9
51
1.78
0.95
2.1
1.4
—
—
—
0
0
9
51
1.78
0.95
2.1
1.4
—
—
—
0
0
6
27
2.24
0.94
1.0
2.6
3.80
3.47
nmol/l
—
6
27
6
30
2.02
0.87
1.0
1.2
—
—
—
0
0
6
32
1.89
0.82
4.2
1.5
—
—
—
0
0
7
38
1.86
0.74
4.1
1.4
—
—
—
0
0
21
151
1.42
0.73
1.9
1.9
—
—
—
0
0
7
41
1.72
0.70
1.3
1.7
—
—
—
0
0
7
41
1.72
0.70
4.6
1.5
—
—
—
0
0
249
2370
1.18
0.70
7.4
5.6
41.50
39.83
mmol/mol
1.71
241
2153
5
27
1.86
0.68
1.0
1.1
—
—
—
0
0
5
28
1.80
0.66
2.6
3.4
—
—
—
0
0
37
298
1.27
0.64
2.5
4.0
113.79
47.41
ug/l
0.25
31
251
28
356
0.77
0.64
20.8
6.5
—
—
—
0
0
10
63
1.60
0.62
1.0
1.1
—
15.49
—
0
7
5
30
1.68
0.61
1.0
1.1
—
—
—
0
0
13
89
1.48
0.59
2.6
3.0
—
—
—
0
0
8
53
1.52
0.59
1.1
1.6
—
—
—
0
0
72
637
1.16
0.51
1.8
1.6
1.45
1.31
mmol/l
0.53
61
517
249
2395
1.14
0.50
31.1
12.9
75.21
76.57
ml/min/173m2
0.38
218
1972
21
163
1.31
0.49
2.1
2.0
—
—
—
0
0
7
47
1.50
0.48
4.9
3.2
65.14
57.15
%
—
7
47
19
147
1.31
0.46
6.9
3.3
109.74
69.73
u/ml
0.31
19
141
11
77
1.44
0.46
1.7
1.8
—
—
—
0
0
10
70
1.44
0.42
1.7
1.3
—
—
—
0
0
8
59
1.36
0.41
2.0
1.8
—
—
—
0
0
239
2464
0.90
0.36
4.6
4.2
1.48
1.52
mmol/l
0.66
222
2216
279
2725
1.13
0.35
17.0
9.9
25.76
24.22
u/l
0.81
271
2604
10
73
1.38
0.35
1.9
1.9
—
—
—
0
0
8
65
1.24
0.27
1.9
1.5
250.50
427.89
pmol/l
—
8
65
31
348
0.88
0.24
1.4
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
250
2547
0.93
0.20
5.2
4.8
2.47
2.75
mmol/l
4.39
237
2282
6
50
1.20
0.20
1.0
1.3
—
—
—
0
0
12
143
0.83
0.19
1.0
1.2
189.34
144.28
iu/ml
—
5
56
14
121
1.16
0.15
1.3
1.0
—
—
—
0
0
36
334
1.09
0.14
1.7
1.6
—
—
—
0
0
34
360
0.94
0.09
4.3
4.3
37.24
33.44
%
1.58
29
231
41
431
0.94
0.09
2.9
3.1
0.66
0.74
ug/l
0.31
31
286
6
56
1.07
0.08
1.0
1.1
—
—
—
0
0
5
61
0.82
0.08
1.2
1.4
—
—
—
0
0
246
2483
0.97
0.08
4.6
4.3
4.42
4.69
mmol/l
3.52
231
2250
8
74
1.08
0.07
2.0
1.7
—
—
—
0
0
285
2831
1.04
0.07
45.6
20.1
259.46
245.91
e9/l
2.30
279
2746
285
2831
1.04
0.07
48.0
20.0
37.39
39.62
%
5.51
264
2627
59
609
0.96
0.07
5.5
4.4
23.03
21.73
%
0.24
31
309
253
2509
1.03
0.07
5.2
4.6
6.36
5.96
mmol/l
2.61
226
2222
285
2832
1.04
0.06
45.7
20.1
4.21
4.44
e12/l
9.08
278
2733
74
756
0.97
0.05
5.3
4.8
4.25
4.19
ug/l
0.01
67
667
240
2386
1.02
0.03
4.1
3.8
1.34
1.24
mmol/l
1.13
223
2134
0
7
0.00
0.00
0.0
1.9
—
9.00
—
0
7
6
61
0.98
0.00
1.8
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
6
66
0.91
-0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_FLUIDELECTRONAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_FLUIDELECTRONAS | 2.068 [1.65, 2.59] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.524 |
During the follow-up period (1.1.1998 — 31.12.2019), 438 out of 950 females with E4_FLUIDELECTRONAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_FLUIDELECTRONAS | 5.006 [2.97, 8.43] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 272 out of 534 males with E4_FLUIDELECTRONAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_FLUIDELECTRONAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.155% | 0.87% |
| 5 | 1.318% | 5.3% |
| 10 | 3.19% | 13.38% |
| 15 | 6.384% | 24.389% |
| 20 | 10.98% | 38.141% |
Relationships between endpoints
↥Index endpoint: E4_FLUIDELECTRONAS – Other disorders of electrolyte and fluid balance, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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