Hyperthyroidism: Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
329 |
4. Check minimum number of eventsNone |
329 |
5. Include endpointsNone |
329 |
6. Filter based on genotype QC (FinnGen only) |
322 |
Control definitions (FinnGen only)
- Control exclude
- THYROTOXICOSIS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E05
- Name in latin
- Thyreotoxicosis cum struma uninodulari
Similar endpoints
↥List of similar endpoints to
Thyrotoxicosis with toxic single thyroid nodule
based on the number of shared cases.
Similar with more cases:
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2093 | 1687 | 393 |
| Only index persons | 1884 | 1532 | 352 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.01 |
| Only index persons | 0.05 | 0.06 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 55.27 | 53.98 | 60.60 |
| Only index persons | 53.93 | 52.58 | 59.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 322 | 262 | 60 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.03 |
| Median age at first event (years) | 52.60 | 49.67 | 65.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 329
- Matched controls
- 3290
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
+∞
307.7
307
*
H03BB01
ATC
carbimazole; oral
1009.3
279.2
236
8
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
2358.0
155.2
138
*
BAA60
NOMESCO Finland
Total thyroidectomy
54.3
154.3
91
23
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
1170.7
153.3
138
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
53.0
121.0
71
17
H03AA01
ATC
levothyroxine sodium; systemic
13.0
116.3
243
586
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
25.9
95.2
70
34
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
+∞
80.6
74
*
104
Kela drug reimbursment
Thyroid insufficiency
9.5
67.9
96
137
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
16.5
42.3
37
25
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
226.8
39.8
40
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
8.6
32.2
44
58
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
28.6
27
*
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
293.8
27.1
27
*
C07AA05
ATC
propranolol; systemic
3.6
26.8
127
488
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
24.3
24.9
35
16
2421A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic uninodular goitre
+∞
22.1
21
*
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
+∞
22.1
21
*
T86
ICPC
Hypothyroidism/myxoedema
6.2
21.9
40
72
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.3
21.0
46
98
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
51.5
20.4
24
5
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
16.0
19.9
32
22
E03.89
ICD-10 Finland
Other specified hypothyroidism
6.3
19.7
35
61
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.3
18.6
88
329
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.6
16.4
158
856
E05.89
ICD-10 Finland
Other thyrotoxicosis
+∞
14.7
14
*
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
134.9
12.5
13
*
H062, E050,
ICD-10 Finland
+∞
11.5
11
*
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
9.0
10.7
22
26
2504
FHL
Unilateral resection or enucleation
27.0
9.9
13
5
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
9.0
8.9
18
21
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
51.4
8.7
10
*
BA1AN
NOMESCO Finland
Thyroid gland isotope imaging
+∞
7.3
7
*
106
Kela drug reimbursment
Hypoparathyroidism
40.9
6.8
8
*
A11CC03
ATC
alfacalcidol; systemic
7.4
6.8
15
21
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
23.1
6.7
9
*
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
7.1
6.6
15
22
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.9
6.5
19
51
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
+∞
6.3
6
*
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
+∞
6.3
6
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
6.3
84
487
C07AB07
ATC
bisoprolol; oral
1.8
6.1
160
1144
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
107
37
42.38
167.34
2.2
1.2
4.32
3.78
iu/l
—
49
6
149
150
17.33
142.49
5.4
2.3
4.91
4.34
pmol/l
5.20
136
127
66
187
4.16
21.25
3.7
3.2
69.93
75.50
ng/l
0.20
57
168
309
2253
7.11
21.15
11.3
4.0
15.42
14.63
pmol/l
6.61
296
2059
36
69
5.74
18.42
1.2
1.2
—
—
—
0
0
210
1314
2.65
16.02
8.8
5.5
1.23
1.22
mmol/l
0.82
184
1106
57
215
3.00
11.49
1.2
1.2
156.54
160.46
iu/ml
0.02
26
87
181
1191
2.16
10.52
6.8
4.9
1.23
1.22
mmol/l
0.59
169
1073
311
2637
4.28
9.59
12.7
4.8
1.61
1.88
mu/l
2.51
297
2434
173
1182
1.98
8.42
2.5
2.2
76.77
77.47
nmol/l
0.12
155
1051
106
626
2.02
7.69
2.0
1.9
—
—
—
0
0
54
262
2.27
6.41
1.8
1.9
403.31
376.33
nmol/l
0.51
49
242
175
1302
1.74
5.65
6.0
5.1
56.43
56.96
%
0.23
166
1219
176
1323
1.71
5.38
6.2
5.3
28.59
28.46
%
0.06
167
1240
24
93
2.71
4.58
2.2
1.8
—
—
—
0
0
23
89
2.70
4.41
2.0
1.7
—
—
—
0
0
66
396
1.83
4.33
2.6
2.9
0.80
0.82
mmol/l
0.75
58
372
199
1598
1.62
4.32
8.5
8.7
3.79
3.99
e9/l
0.78
181
1403
13
30
4.47
4.17
6.0
4.7
20.52
75.16
u/ml
—
5
12
249
2129
1.70
4.08
8.0
6.7
77.92
76.91
u/l
0.16
237
1992
163
1269
1.56
3.88
2.5
2.3
—
—
—
0
0
191
1543
1.57
3.85
3.6
3.9
6.65
6.57
mmol/l
0.17
183
1432
125
926
1.56
3.65
3.1
3.1
2.36
2.36
mmol/l
0.11
107
819
166
1311
1.54
3.62
3.0
2.7
87.87
96.74
ug/l
0.41
154
1207
89
619
1.60
3.36
2.1
1.7
0.93
1.05
mg/l
0.40
69
474
62
395
1.70
3.29
1.8
1.8
—
—
—
0
0
242
2107
1.56
3.15
4.4
4.0
11.69
11.76
mm/h
0.02
218
1934
16
64
2.58
2.92
1.4
1.1
16.72
14.92
u/l
0.17
16
50
27
138
2.04
2.84
2.2
1.6
—
—
—
0
0
52
332
1.67
2.74
3.5
4.4
31.50
32.44
%
0.28
36
214
98
727
1.50
2.72
2.8
3.0
1176.54
1089.82
ng/l
0.11
79
617
6
10
6.09
2.71
3.7
1.1
4.15
6.25
umol/l
—
6
10
90
664
1.49
2.55
2.4
2.1
2.68
3.09
mg/l
1.10
81
565
135
1086
1.41
2.39
2.1
2.0
96.89
97.14
pmol/l
0.02
76
531
284
2618
1.62
2.37
13.7
12.0
80.93
82.09
ml/min/173m2
0.36
247
2145
9
28
3.27
2.32
1.0
1.0
—
—
—
0
0
35
211
1.74
2.28
3.1
3.1
5.87
5.72
kpa
0.39
35
206
69
494
1.50
2.24
3.1
2.7
2.46
2.45
mmol/l
0.16
58
438
211
1858
1.38
2.05
3.0
2.9
34.75
42.73
u/l
1.86
201
1738
64
462
1.48
2.00
3.3
3.6
44.32
140.27
ng/l
1.56
47
335
276
2553
1.50
1.99
6.6
5.5
39.87
39.30
mmol/mol
0.42
261
2390
88
680
1.40
1.91
3.4
2.5
10566.70
9365.35
umol/l
0.06
82
591
98
780
1.37
1.77
3.7
3.6
22.66
7.92
mg/mmol
0.74
58
456
9
36
2.54
1.75
1.4
1.3
—
—
—
0
0
298
2822
1.59
1.70
17.4
14.3
3.95
3.95
mmol/l
0.07
292
2748
10
41
2.48
1.66
1.1
1.6
—
—
—
0
0
308
2945
1.72
1.62
11.9
9.7
23.56
24.47
u/l
0.52
299
2850
5
14
3.61
1.62
1.2
1.1
6.80
16.36
u/l
—
5
14
5
14
3.61
1.62
1.0
1.1
54.80
56.99
u/l
—
5
14
13
63
2.11
1.62
1.0
1.4
—
—
—
0
0
97
788
1.33
1.51
2.1
2.0
133.15
160.17
u/l
0.38
91
743
9
37
2.47
1.49
1.1
1.1
—
—
—
0
0
279
2624
1.42
1.47
4.3
3.9
1.27
1.26
mmol/l
0.09
260
2419
292
2770
1.48
1.45
15.7
12.6
20.70
20.65
mg/l
0.01
241
2138
13
66
2.01
1.45
1.8
1.4
—
—
—
0
0
58
752
0.72
1.45
4.9
4.0
0.00
0.00
estimate
0.50
19
282
102
848
1.29
1.33
2.1
2.2
57.46
55.97
u/l
0.19
90
781
69
544
1.34
1.31
1.5
1.5
—
—
—
0
0
6
24
2.53
1.31
1.0
1.2
—
—
—
0
0
6
24
2.53
1.31
1.0
1.2
—
—
—
0
0
162
1429
1.26
1.31
4.5
5.5
10.93
10.07
umol/l
0.32
148
1345
130
1118
1.27
1.29
5.0
3.9
35.83
36.06
g/l
0.19
123
1039
5
18
2.80
1.29
2.8
2.1
—
—
—
0
0
13
70
1.89
1.25
1.2
1.2
—
—
—
0
0
6
25
2.43
1.25
1.2
1.2
—
—
—
0
0
12
63
1.94
1.24
1.5
1.4
—
—
—
0
0
137
1194
1.25
1.20
13.8
11.1
1.33
1.20
inr
0.76
42
367
8
38
2.13
1.19
1.1
1.4
—
—
—
0
0
8
38
2.13
1.19
1.1
1.4
—
—
—
0
0
287
2737
1.38
1.15
4.8
4.4
4.83
4.79
mmol/l
0.30
269
2547
10
51
1.99
1.12
1.2
1.1
5.94
2.55
u/ml
—
5
23
291
2793
1.36
1.01
5.1
4.8
2.92
2.82
mmol/l
0.98
269
2585
314
3057
1.60
0.97
24.9
18.9
39.83
39.83
%
0.00
303
2878
21
142
1.51
0.95
4.0
2.9
0.09
0.20
e6/l
0.67
21
137
281
2689
1.31
0.94
4.9
4.4
5.86
5.87
mmol/l
0.05
259
2474
12
70
1.74
0.94
1.6
2.5
—
—
—
0
0
314
3060
1.57
0.92
25.4
19.1
133.93
133.60
g/l
0.19
314
3021
6
28
2.16
0.92
1.2
1.2
—
72.20
—
0
5
113
990
1.22
0.90
3.6
3.6
94.14
34.54
ng/l
0.58
81
646
19
129
1.50
0.85
3.2
5.0
24.57
25.16
mmol/l
0.23
19
129
68
570
1.24
0.83
1.3
1.3
11.74
38.27
iu/ml
5.43
14
189
0
24
0.00
0.79
0.0
1.3
—
—
—
0
0
283
2727
1.27
0.77
4.8
4.3
1.50
1.54
mmol/l
1.03
264
2529
6
34
1.78
0.76
1.8
1.5
—
—
—
0
0
11
68
1.64
0.72
1.2
1.2
—
—
—
0
0
35
275
1.31
0.72
1.7
1.7
—
—
—
0
0
5
26
1.94
0.71
3.8
3.1
—
—
—
0
0
193
1803
1.17
0.70
3.4
3.2
—
—
—
0
0
26
196
1.35
0.70
3.2
5.4
1.15
1.39
mmol/l
0.67
26
191
38
304
1.28
0.69
4.0
4.6
23.10
19.86
%
0.41
14
143
78
678
1.20
0.67
1.3
1.2
0.70
1.49
u/ml
1.40
21
191
47
388
1.25
0.67
5.6
5.0
3.52
2.85
ug/l
0.19
41
346
49
407
1.24
0.66
3.9
2.8
5.12
2.93
e6/l
0.54
28
214
7
44
1.60
0.65
2.7
2.6
105.86
105.98
mmol/l
—
7
44
101
901
1.17
0.65
2.3
2.9
30.96
29.78
u/l
0.15
96
858
35
280
1.28
0.64
1.7
1.7
—
—
—
0
0
25
322
0.76
0.63
8.4
6.5
—
—
—
0
0
10
63
1.61
0.62
6.1
4.2
8.18
31.23
mg/l
—
5
37
9
140
0.63
0.62
4.6
6.9
23.78
24.83
mmol/l
—
9
132
76
665
1.19
0.61
1.5
1.5
19.03
22.14
nmol/l
0.93
66
559
28
223
1.28
0.54
2.1
3.0
0.65
0.71
ug/l
0.15
17
147
6
39
1.55
0.53
1.0
1.1
—
—
—
0
0
30
246
1.24
0.47
1.6
1.7
—
—
—
0
0
7
48
1.47
0.47
1.3
1.4
—
—
—
0
0
7
48
1.47
0.47
1.3
1.4
—
—
—
0
0
7
50
1.41
0.45
1.1
1.2
—
—
—
0
0
30
248
1.23
0.45
3.1
6.4
5.35
5.14
kpa
0.49
30
238
30
248
1.23
0.45
3.1
6.4
11.37
12.24
kpa
0.41
30
238
6
92
0.65
0.43
3.3
2.2
8.42
10.23
g/l
—
6
87
236
2439
0.89
0.42
19.4
15.4
15.36
14.80
%
0.65
236
2411
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
67
742
0.88
0.40
3.7
2.9
0.25
0.36
e6/l
0.49
48
560
14
106
1.34
0.39
2.2
1.6
—
—
—
0
0
0
19
0.00
0.39
0.0
1.5
—
—
—
0
0
49
432
1.16
0.38
3.0
2.6
2.10
1.05
e6/l
0.41
28
236
16
125
1.29
0.37
1.5
1.5
—
—
—
0
0
6
41
1.47
0.36
2.0
3.1
18.83
55.76
u/ml
—
6
41
6
43
1.40
0.35
1.2
1.4
—
—
—
0
0
6
45
1.34
0.34
1.0
1.1
—
—
—
0
0
12
92
1.32
0.32
1.2
1.4
392.72
229.74
miu/ml
—
5
46
68
622
1.12
0.32
1.5
1.4
—
—
—
0
0
8
62
1.30
0.28
1.1
1.4
—
—
—
0
0
103
1090
0.92
0.27
4.6
3.8
—
—
—
0
0
53
485
1.11
0.25
1.7
1.7
888.17
1255.97
nmol/l
2.73
38
366
6
84
0.71
0.24
7.8
2.6
5.15
0.62
g/l
—
6
79
72
770
0.92
0.24
1.8
1.6
1.28
1.39
mmol/l
0.68
63
652
5
38
1.32
0.23
1.0
1.3
0.76
0.60
nmol/l
—
5
33
16
134
1.20
0.23
3.6
2.9
2.10
1.62
mmol/l
0.21
11
98
5
39
1.29
0.23
1.2
1.3
—
—
—
0
0
19
220
0.86
0.22
1.9
2.5
—
19.28
—
0
12
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
110.39
—
0
10
0
10
0.00
0.21
0.0
1.6
—
101.90
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
4.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
4.1
—
—
—
0
0
23
202
1.15
0.20
3.6
7.0
123.96
120.64
g/l
0.35
23
197
0
14
0.00
0.20
0.0
2.1
—
108.57
—
0
14
15
175
0.85
0.19
1.1
1.3
—
—
—
0
0
10
81
1.24
0.19
1.8
1.4
—
—
—
0
0
10
81
1.24
0.19
1.8
1.4
—
—
—
0
0
10
81
1.24
0.19
1.8
1.4
—
—
—
0
0
10
81
1.24
0.19
1.8
1.4
—
—
—
0
0
56
598
0.92
0.18
5.1
3.9
1.01
1.02
kg/l
0.87
15
86
12
100
1.21
0.18
1.9
1.4
—
—
—
0
0
8
69
1.16
0.16
6.5
3.5
35.41
26.96
mg/l
—
8
54
8
69
1.16
0.16
6.5
3.5
48.00
59.30
mg/l
—
8
55
16
181
0.88
0.14
1.3
1.5
—
—
—
0
0
8
98
0.81
0.14
2.9
2.1
—
—
—
0
0
17
190
0.89
0.13
1.1
1.3
—
42.97
—
0
10
11
95
1.16
0.12
2.9
4.6
1.28
1.50
%
0.98
11
88
5
45
1.11
0.10
1.2
1.3
—
—
—
0
0
27
252
1.08
0.09
3.1
2.3
123.05
32.77
u/l
0.60
22
214
24
223
1.08
0.09
3.1
2.6
66.42
67.63
ml/min/173m2
0.05
12
87
5
48
1.04
0.09
2.0
1.6
—
—
—
0
0
17
155
1.10
0.09
1.6
1.4
—
—
—
0
0
30
282
1.07
0.09
2.2
4.0
2.83
47.44
ug/l
0.91
23
228
137
1396
0.97
0.08
4.2
3.7
0.00
0.00
estimate
0.50
24
306
6
58
1.04
0.08
1.0
1.4
—
—
—
0
0
5
60
0.83
0.08
1.4
1.8
—
—
—
0
0
7
64
1.10
0.08
1.3
1.7
—
—
—
0
0
7
66
1.06
0.08
1.0
1.2
—
47.13
—
0
6
61
590
1.04
0.07
1.5
1.7
170370802.46
441.21
pmol/l
0.49
54
493
6
74
0.81
0.07
1.5
1.2
—
—
—
0
0
138
1403
0.97
0.07
6.1
5.1
0.00
0.00
estimate
0.50
20
280
9
87
1.04
0.07
1.8
1.5
—
—
—
0
0
9
88
1.02
0.07
1.6
1.8
—
—
—
0
0
58
565
1.03
0.05
1.3
1.3
1.08
14.09
u/ml
4.47
18
227
10
92
1.09
0.03
1.7
2.0
—
—
—
0
0
33
340
0.97
0.03
1.7
2.0
—
—
—
0
0
16
152
1.06
0.02
1.0
1.0
—
—
—
0
0
28
272
1.03
0.02
2.7
3.2
—
—
—
0
0
94
949
0.99
0.01
4.3
3.0
—
—
—
0
0
15
144
1.04
0.00
1.3
1.8
—
—
—
0
0
14
146
0.96
0.00
1.7
1.5
—
—
—
0
0
141
1416
0.99
0.00
4.4
3.8
0.00
0.01
estimate
0.50
20
276
10
102
0.98
0.00
1.1
1.1
—
—
—
0
0
19
192
0.99
0.00
1.4
1.8
—
—
—
0
0
10
103
0.97
0.00
1.2
2.0
—
—
—
0
0
10
104
0.96
0.00
1.1
1.1
—
—
—
0
0
19
194
0.98
0.00
2.8
2.5
67.64
67.40
g/l
0.05
19
175
30
304
0.99
0.00
1.6
1.8
—
—
—
0
0
5
52
0.96
0.00
2.8
2.9
59.40
58.38
%
—
5
52
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
8.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
1.19
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYTOXNOD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXNOD | 1.287 [1.09, 1.53] | 0.004 |
| Birth year | 0.996 [0.99, 1.0] | 0.403 |
During the follow-up period (1.1.1998 — 31.12.2019), 211 out of 1340 females with E4_THYTOXNOD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXNOD | 1.204 [0.89, 1.62] | 0.223 |
| Birth year | 0.987 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 68 out of 290 males with E4_THYTOXNOD died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYTOXNOD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.172% | 0.275% |
| 5 | 0.855% | 1.442% |
| 10 | 2.072% | 3.605% |
| 15 | 3.994% | 6.787% |
| 20 | 6.997% | 11.648% |
Relationships between endpoints
↥Index endpoint: E4_THYTOXNOD – Thyrotoxicosis with toxic single thyroid nodule
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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