Hyperthyroidism: Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
307 |
4. Check minimum number of eventsNone |
307 |
5. Include endpointsNone |
307 |
6. Filter based on genotype QC (FinnGen only) |
307 |
Control definitions (FinnGen only)
- Control exclude
- THYROTOXICOSIS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E05
- Name in latin
- Thyreotoxicosis cum struma uninodulari
Similar endpoints
↥List of similar endpoints to
Thyrotoxicosis with toxic single thyroid nodule
based on the number of shared cases.
Similar with more cases:
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2093 | 1687 | 393 |
| Only index persons | 1884 | 1532 | 352 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.01 |
| Only index persons | 0.05 | 0.06 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 55.27 | 53.98 | 60.60 |
| Only index persons | 53.93 | 52.58 | 59.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 307 | 253 | 54 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.02 |
| Median age at first event (years) | 52.31 | 49.52 | 65.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 277
- Matched controls
- 2771
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
+∞
323.0
257
*
H03BB01
ATC
carbimazole; oral
1991.3
232.2
193
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
2125.9
136.4
121
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
2004.6
131.4
117
*
H03AA01
ATC
levothyroxine sodium; systemic
12.5
78.3
202
491
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
807.0
66.9
63
*
BAA60
NOMESCO Finland
Total thyroidectomy
47.0
62.7
76
22
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
43.9
50.5
62
18
104
Kela drug reimbursment
Thyroid insufficiency
8.8
35.9
84
130
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
18.7
35.8
56
37
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
337.1
30.4
30
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
26.5
25
*
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
23.2
23.2
33
16
2421A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic uninodular goitre
+∞
20.0
19
*
C07AA05
ATC
propranolol; systemic
3.9
19.2
97
339
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
14.8
16.4
27
20
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
35.7
16.0
20
6
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
12.8
16.0
28
24
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
90.3
15.7
17
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.8
14.1
41
81
E05.89
ICD-10 Finland
Other thyrotoxicosis
+∞
13.6
13
*
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
146.9
13.6
14
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
6.7
13.2
34
57
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.3
12.0
66
238
H062, E050
ICD-10 Finland
NA
+∞
11.5
11
*
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
41.7
10.0
12
*
T86
ICPC
Hypothyroidism/myxoedema
5.2
9.2
28
59
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
51.6
8.7
10
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
8.7
114
662
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
7.5
8.4
19
27
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
8.5
8.2
17
21
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
46.3
7.8
9
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.0
7.5
130
836
C07AB07
ATC
bisoprolol; oral
2.0
6.8
128
839
106
Kela drug reimbursment
Hypoparathyroidism
41.1
6.8
8
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
4.2
6.4
23
59
2504
FHL
Unilateral resection or enucleation
11.4
6.3
11
10
BA1AN
NOMESCO Finland
Thyroid gland isotope imaging
+∞
6.3
6
*
T85
ICPC
Hyperthyroidism/thyrotoxicosis
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3017044) Thyrotropin receptor Ab [Units/volume] in Serum
90
37
34.00
132.13
2.1
1.2
iu/l
4.2
3.7
—
40
6
(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma
131
140
15.58
119.61
5.7
2.3
pmol/l
4.8
4.3
3.99
118
119
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
287
2098
6.65
19.27
11.4
4.0
pmol/l
15.5
14.6
7.52
274
1918
(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma
60
180
3.90
17.78
3.8
3.2
ng/l
68.9
76.0
0.25
52
162
(3043109) Cytology report of Tissue fine needle aspirate Cyto stain
34
68
5.50
16.62
1.1
1.2
—
—
—
0
0
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
195
1242
2.56
13.97
9.1
5.5
mmol/l
1.2
1.2
0.35
169
1042
(3019225) pH of Specimen
61
231
3.05
12.32
3.9
3.7
—
—
—
0
0
(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma
53
199
3.01
10.80
1.2
1.2
iu/ml
168.7
175.4
0.04
24
79
(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma
170
1126
2.14
9.70
7.0
4.9
mmol/l
1.2
1.2
0.42
158
1015
(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma
12
14
8.88
9.41
5.8
8.9
—
—
—
0
0
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
289
2456
4.01
8.65
12.8
4.8
mu/l
1.7
1.9
1.47
276
2267
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
162
1118
1.95
7.59
2.6
2.2
nmol/l
77.4
77.5
0.02
145
993
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
99
586
2.02
7.16
2.0
1.9
—
—
—
0
0
(3036481) Cortisol [Moles/volume] in Serum or Plasma
53
246
2.40
7.02
1.8
1.9
nmol/l
405.0
371.9
0.65
48
227
(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma
18
48
3.92
6.18
1.4
2.5
—
—
—
0
0
(3018010) Neutrophils/100 leukocytes in Blood
165
1209
1.79
5.85
6.1
5.1
%
56.1
57.2
0.51
156
1131
(3025547) Thyroglobulin Ab [Units/volume] in Serum or Plasma
13
28
4.80
5.79
6.0
4.9
u/ml
20.5
81.5
—
5
11
(3002030) Lymphocytes/100 leukocytes in Blood
166
1227
1.77
5.64
6.3
5.2
%
28.7
28.3
0.21
156
1141
(3019198) Lymphocytes [#/volume] in Blood
175
1315
1.77
5.60
5.7
5.1
e9/l
1.8
1.9
0.32
156
1171
(3044640) Blood type and Crossmatch panel - Blood
116
791
1.75
5.09
2.1
2.1
—
—
—
0
0
(3006504) Eosinophils/100 leukocytes in Blood
160
1194
1.71
5.06
6.1
5.1
%
3.2
2.7
1.36
149
1102
(3001604) Monocytes [#/volume] in Blood
169
1281
1.71
5.04
5.6
5.1
e9/l
0.6
0.6
0.03
145
1116
(3019069) Monocytes/100 leukocytes in Blood
160
1197
1.70
4.99
6.5
5.3
%
8.5
8.3
0.25
148
1116
(3006315) Basophils [#/volume] in Blood
169
1286
1.70
4.92
5.6
5.1
e9/l
0.0
0.0
0.74
146
1118
(3013115) Eosinophils [#/volume] in Blood
174
1338
1.69
4.84
5.7
5.4
e9/l
0.2
0.2
1.04
156
1182
(3012095) Magnesium [Moles/volume] in Serum or Plasma
64
375
1.89
4.57
2.5
2.8
mmol/l
0.8
0.8
0.59
56
352
(3022096) Basophils/100 leukocytes in Blood
153
1153
1.65
4.48
6.2
5.2
%
0.7
0.7
0.42
142
1065
(3035637) Corticotropin [Mass/volume] in Plasma
11
26
4.35
4.39
1.4
1.5
—
—
—
0
0
(3013650) Neutrophils [#/volume] in Blood by Automated count
186
1486
1.64
4.22
8.5
8.5
e9/l
3.8
4.0
0.95
168
1301
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
153
1175
1.60
4.01
3.9
3.8
—
—
—
0
0
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
22
88
2.62
3.98
2.3
1.9
—
—
—
0
0
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
21
82
2.68
3.97
2.1
1.7
—
—
—
0
0
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
85
572
1.67
3.75
2.2
1.7
mg/l
0.9
1.1
0.48
66
440
(3009214) Lutropin [Units/volume] in Serum or Plasma
16
57
2.91
3.58
1.4
1.1
u/l
16.7
14.5
0.22
16
44
(3001019) Free T4 and TSH panel - Serum or Plasma
32
161
2.10
3.49
2.4
1.8
—
—
—
0
0
(3017732) Neutrophils [#/volume] in Blood
34
176
2.05
3.45
2.8
2.2
e9/l
3.6
3.9
0.32
24
143
(3015377) Calcium [Moles/volume] in Serum or Plasma
118
878
1.56
3.39
3.2
3.1
mmol/l
2.4
2.4
0.23
98
776
(3001122) Ferritin [Mass/volume] in Serum or Plasma
154
1224
1.52
3.23
3.2
2.8
ug/l
89.3
97.3
0.33
142
1126
(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
230
1999
1.60
3.16
8.1
6.7
u/l
77.5
76.8
0.09
219
1869
(3013826) Glucose [Moles/volume] in Serum or Plasma
176
1444
1.51
3.14
3.5
4.0
mmol/l
6.5
6.6
0.25
169
1339
(3013707) Erythrocyte sedimentation rate by Westergren method
227
1974
1.58
3.04
4.5
4.1
mm/h
11.9
11.8
0.02
205
1818
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
131
1020
1.50
2.96
2.1
2.0
pmol/l
97.6
96.5
0.09
72
497
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
58
375
1.67
2.93
1.8
1.8
—
—
—
0
0
(3016616) Dehydroepiandrosterone sulfate (DHEA-S) [Moles/volume] in Serum or Plasma
6
9
6.77
2.88
3.7
1.1
umol/l
4.2
6.5
—
6
9
(42870588) Differential panel, method unspecified - Blood
110
832
1.50
2.84
5.6
5.0
—
—
—
0
0
(3018418) pH of Serum or Plasma
103
772
1.50
2.77
6.1
3.5
ph
7.4
7.4
0.83
18
152
(40768804) Tissue Pathology biopsy report
138
1108
1.45
2.58
2.1
2.1
—
—
—
0
0
(3013512) EKG study
97
729
1.48
2.54
3.6
3.7
—
—
—
0
0
(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
84
619
1.49
2.41
2.5
2.1
mg/l
2.7
3.1
0.97
75
527
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
25
133
1.96
2.39
2.0
1.6
—
—
—
0
0
(3026493) Urate [Moles/volume] in Serum or Plasma
85
635
1.47
2.27
3.4
2.4
umol/l
11089.9
7400.5
0.19
78
545
(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma
48
316
1.62
2.27
3.6
4.4
%
31.4
32.4
0.28
33
200
(3012544) pH of Venous blood
34
204
1.75
2.26
3.3
3.0
—
—
—
0
0
(3000492) Spirometry study
37
230
1.69
2.18
1.2
1.4
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
263
2428
1.58
2.10
13.7
12.2
ml/min/173m2
80.5
81.6
0.33
228
1987
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
90
689
1.43
2.10
2.8
3.0
ng/l
1222.7
1129.9
0.11
72
588
(3022217) INR in Platelet poor plasma by Coagulation assay
42
274
1.62
2.06
22.9
19.1
inr
1.7
1.2
—
9
36
(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing
10
39
2.62
1.94
1.1
1.6
—
—
—
0
0
(3009508) Creatinine [Moles/volume] in Urine
93
726
1.40
1.93
3.0
2.9
mmol/l
7.2
7.1
0.09
78
605
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
195
1717
1.37
1.90
3.1
2.9
u/l
35.0
41.7
1.33
185
1603
(3020682) Albumin/Creatinine [Ratio] in Urine
93
729
1.40
1.88
3.7
3.8
mg/mmol
19.9
8.0
0.55
55
425
(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability
9
34
2.70
1.88
1.6
1.2
—
—
—
0
0
(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay
9
34
2.70
1.88
1.1
1.1
—
—
—
0
0
(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood
8
28
2.91
1.87
1.0
1.0
—
—
—
0
0
(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma
64
473
1.45
1.79
3.2
2.8
mmol/l
2.4
2.5
0.18
53
420
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
257
2383
1.48
1.77
6.7
5.6
mmol/mol
39.7
39.3
0.30
242
2230
(3012516) Albumin [Mass/volume] in Urine
87
681
1.39
1.76
3.1
3.0
mg/l
715.3
48.6
0.63
55
400
(40768806) Pleura Pathology biopsy report
6
18
3.38
1.75
1.2
1.5
—
—
—
0
0
(3000991) Gas panel - Venous blood
27
164
1.71
1.75
3.7
7.0
—
—
—
0
0
(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay
13
61
2.18
1.74
1.8
1.4
—
—
—
0
0
(1761482) Bacteria [#/volume] in Urine by Culture
15
75
2.05
1.72
2.3
5.2
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
78
604
1.39
1.68
3.7
4.1
—
—
—
0
0
(3023103) Potassium [Moles/volume] in Serum or Plasma
278
2629
1.61
1.65
17.3
14.5
mmol/l
3.9
3.9
0.36
273
2558
(3047007) Chlamydophila sp Ab [Presence] in Serum
8
32
2.54
1.61
1.3
1.1
—
—
—
0
0
(4024509)
6
20
3.04
1.59
1.7
1.4
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
67
511
1.40
1.58
1.5
1.5
—
—
—
0
0
(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma
58
432
1.42
1.56
3.3
3.6
ng/l
44.8
141.6
1.45
43
317
(3029937) Albumin [Presence] in Urine by Test strip
53
701
0.71
1.51
5.2
4.0
estimate
0.0
0.0
0.50
18
261
(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay
13
65
2.04
1.51
1.2
1.1
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
12
226
0.51
1.49
3.3
3.7
—
—
—
0
0
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
12
60
2.04
1.40
1.0
1.5
—
—
—
0
0
(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
90
733
1.32
1.39
2.2
2.0
u/l
133.8
163.2
0.38
84
694
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
260
2445
1.41
1.38
4.3
3.9
mmol/l
1.3
1.3
0.15
243
2256
(44790047)
6
23
2.64
1.37
1.0
1.2
—
—
—
0
0
(44790049)
6
23
2.64
1.37
1.0
1.2
—
—
—
0
0
(44806118)
6
23
2.64
1.37
1.0
1.2
—
—
—
0
0
(44790048)
6
23
2.64
1.37
1.0
1.2
—
—
—
0
0
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
272
2580
1.48
1.36
15.8
12.8
mg/l
21.0
20.8
0.04
223
1996
(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture
5
18
2.81
1.29
2.8
2.1
—
—
—
0
0
(3024928) Oxygen saturation in Venous blood
9
44
2.08
1.28
1.9
1.9
—
—
—
0
0
(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method
6
25
2.43
1.25
1.2
1.2
—
—
—
0
0
(3000330) Specific gravity of Urine by Test strip
21
132
1.63
1.24
2.8
4.1
—
—
—
0
0
(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma
286
2750
1.58
1.23
12.0
9.6
u/l
23.3
24.1
0.41
277
2660
(3011391) Calcitriol [Moles/volume] in Serum or Plasma
6
26
2.33
1.19
1.3
1.2
—
—
—
0
0
(3007628) Bicarbonate [Moles/volume] standard in Venous blood
15
87
1.76
1.17
3.7
3.3
mmol/l
25.0
24.5
0.16
15
80
(3033658) Prothrombin time (PT) actual/Normal
75
610
1.30
1.16
4.0
3.3
%
94.9
94.9
0.01
69
593
(3028192) IgG subclass 2 [Mass/volume] in Serum
5
20
2.52
1.15
1.8
1.4
g/l
4.2
2.7
—
5
15
(3024139) IgG subclass 3 [Mass/volume] in Serum
5
20
2.52
1.15
1.8
1.4
g/l
0.4
0.3
—
5
15
(4062490)
5
20
2.52
1.15
1.8
1.4
—
—
—
0
0
(3027135) IgG subclass 1 [Mass/volume] in Serum
5
20
2.52
1.15
1.8
1.4
g/l
5.8
6.2
—
5
15
(40758558) Short blood count panel - Blood
79
648
1.30
1.15
6.6
6.6
—
—
—
0
0
(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma
95
799
1.27
1.14
2.2
2.2
u/l
56.6
56.3
0.02
83
735
(3037467) Urinalysis macro (dipstick) panel - Urine
197
1806
1.25
1.10
5.3
4.3
—
—
—
0
0
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
264
2512
1.36
1.09
5.0
4.4
mmol/l
5.8
5.9
0.20
242
2311
(3024561) Albumin [Mass/volume] in Serum or Plasma
121
1054
1.24
1.07
5.1
3.9
g/l
35.7
36.0
0.27
114
979
(3004616) Nuclear Ab [Presence] in Serum
7
33
2.15
1.06
1.3
1.2
—
—
—
0
0
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
267
2548
1.37
1.05
4.9
4.3
mmol/l
4.8
4.8
0.23
250
2371
(3050238) Crystals [Presence] in Synovial fluid by Light microscopy
11
60
1.86
1.04
1.5
1.5
—
—
—
0
0
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
11
60
1.86
1.04
1.2
1.2
—
—
—
0
0
(4035726)
33
240
1.42
1.04
1.4
1.4
—
—
—
0
0
(3008757) Leukocyte morphology finding [Identifier] in Blood
5
22
2.29
1.04
3.6
3.5
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
44
338
1.35
1.01
2.0
1.9
—
—
—
0
0
(3023410) Appearance of Cerebral spinal fluid
0
29
0.00
0.98
0.0
1.1
—
—
—
0
0
(3002256) Pathology report gross observation
43
331
1.35
0.98
1.2
1.2
—
—
—
0
0
(3025159) Blasts/100 leukocytes in Blood
26
183
1.46
0.97
4.6
4.1
%
0.0
0.0
—
7
42
(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma
150
1349
1.22
0.95
4.5
5.4
umol/l
11.1
10.1
0.37
136
1268
(40768797) Stomach Pathology biopsy report
47
370
1.32
0.93
1.2
1.2
—
—
—
0
0
(3017446) Testosterone [Moles/volume] in Serum or Plasma
13
78
1.70
0.93
4.0
2.1
nmol/l
9.8
12.1
0.42
13
73
(3026389) Candida sp identified in Specimen by Organism specific culture
6
28
2.16
0.92
1.8
1.2
—
—
—
0
0
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
35
264
1.37
0.91
4.1
4.8
%
24.0
19.5
0.57
13
128
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
15
95
1.61
0.89
1.4
1.7
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
245
2328
1.26
0.86
18.2
13.8
%
39.0
39.5
0.35
182
1709
(3024731) MCV [Entitic volume]
292
2846
1.53
0.84
25.4
19.0
fl
90.6
91.1
1.00
292
2808
(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma
43
340
1.31
0.83
5.7
5.1
ug/l
3.8
3.0
0.19
37
304
(3003740) Influenza virus B Ag [Presence] in Specimen
8
47
1.72
0.81
1.1
1.1
—
—
—
0
0
(3002523) Influenza virus A Ag [Presence] in Specimen
8
47
1.72
0.81
1.1
1.1
—
—
—
0
0
(3035941) MCH [Entitic mass]
292
2848
1.52
0.81
25.3
19.0
pg
30.1
30.2
0.87
292
2810
(3000963) Hemoglobin [Mass/volume] in Blood
292
2849
1.51
0.79
25.6
19.2
g/l
133.8
133.5
0.18
292
2811
(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma
270
2603
1.31
0.79
5.2
4.8
mmol/l
2.9
2.8
0.83
248
2409
(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
95
830
1.21
0.79
2.4
2.8
u/l
31.6
29.4
0.29
90
790
(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection
0
26
0.00
0.79
0.0
1.2
—
—
—
0
0
(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection
0
26
0.00
0.79
0.0
1.2
—
—
—
0
0
(3021440) Promyelocytes/100 leukocytes in Blood
26
192
1.39
0.78
4.6
4.0
%
0.1
0.1
—
8
51
(3002385) Erythrocyte distribution width [Ratio]
207
2190
0.83
0.77
20.3
15.8
%
13.6
13.7
0.32
207
2160
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
264
2540
1.28
0.77
4.9
4.3
mmol/l
1.5
1.5
1.24
246
2355
(3051387) C reactive protein [Mass/volume] in Capillary blood
10
59
1.72
0.76
6.1
4.3
mg/l
8.2
31.1
—
5
36
(1761868) Lipid panel - Serum or Plasma
107
950
1.19
0.75
2.9
2.9
—
—
—
0
0
(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma
26
194
1.37
0.74
2.0
3.0
ug/l
0.7
0.7
0.04
15
131
(3017181) Myelocytes/100 leukocytes in Blood
27
203
1.36
0.74
4.7
4.0
%
2.0
0.9
—
8
54
(4094501)
10
60
1.69
0.73
1.0
1.1
—
—
—
0
0
(44816844) Macroprolactin [Units/volume] in Serum or Plasma
5
26
1.94
0.71
1.6
1.2
—
—
—
0
0
(3027544) Mycobacterium sp identified in Sputum by Organism specific culture
5
26
1.94
0.71
3.8
3.1
—
—
—
0
0
(3037121) Protein [Mass/volume] in Urine
13
85
1.55
0.70
2.6
3.5
g/l
1.1
0.2
—
6
28
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
11
69
1.62
0.69
1.6
2.4
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
32
250
1.31
0.69
1.2
1.4
—
—
—
0
0
(3041354) Potassium [Moles/volume] in Venous blood
7
42
1.68
0.69
2.7
2.5
mmol/l
4.0
3.9
—
7
42
(3033705) Calcium.ionized [Moles/volume] in Venous blood
7
42
1.68
0.69
2.7
2.5
—
—
—
0
0
(3035285) Chloride [Moles/volume] in Venous blood
7
42
1.68
0.69
2.7
2.5
mmol/l
105.9
106.2
—
7
42
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
104
928
1.18
0.68
3.7
3.6
ng/l
102.0
35.8
0.59
74
608
(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma
63
537
1.22
0.67
1.4
1.3
iu/ml
11.7
39.8
5.14
12
168
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
36
288
1.28
0.66
1.7
1.8
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
33
261
1.30
0.66
1.5
1.7
—
—
—
0
0
(3027945) Reticulocytes/100 erythrocytes in Blood
33
261
1.30
0.66
1.7
2.8
%
1.6
1.8
0.80
28
237
(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma
7
44
1.60
0.65
1.1
1.2
—
—
—
0
0
(3030981) Hyaline casts [#/volume] in Urine by Automated count
18
129
1.42
0.65
4.3
3.0
e6/l
0.1
0.2
0.61
18
124
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
46
381
1.24
0.64
4.0
2.8
e6/l
5.5
3.0
0.58
26
198
(3048689) Calprotectin [Mass/mass] in Stool
41
335
1.26
0.64
2.0
2.1
ug/g
90.9
121.6
0.40
32
252
(3021960) Folate [Moles/volume] in Serum or Plasma
72
626
1.20
0.63
1.5
1.5
nmol/l
19.4
22.2
0.72
62
524
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
16
113
1.44
0.62
1.5
1.5
—
—
—
0
0
(3002179) Metamyelocytes/100 leukocytes in Blood
24
183
1.34
0.61
4.7
3.9
%
5.0
0.4
—
6
36
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
179
1679
1.16
0.60
3.4
3.2
—
—
—
0
0
(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma
0
20
0.00
0.60
0.0
1.5
—
1.0
—
0
20
(3026008) Bacteria identified in Urine by Culture
94
841
1.17
0.59
3.4
3.0
—
—
—
0
0
(3016018) Differential panel - Cerebral spinal fluid
0
23
0.00
0.58
0.0
1.1
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
33
266
1.27
0.58
1.5
1.7
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
277
2699
1.27
0.57
16.2
12.0
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
17
124
1.39
0.57
2.6
5.1
mmol/l
24.4
25.2
0.27
17
124
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
24
305
0.77
0.56
8.6
6.6
—
—
—
0
0
(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence
6
37
1.63
0.56
1.0
1.1
—
—
—
0
0
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
9
61
1.49
0.54
1.2
1.1
—
—
—
0
0
(3021788) Differential panel - Synovial fluid
6
39
1.55
0.53
1.2
1.8
—
—
—
0
0
(3014111) Lactate [Moles/volume] in Serum or Plasma
24
188
1.30
0.53
2.9
5.6
mmol/l
1.1
1.3
0.55
24
180
(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum
71
629
1.17
0.51
1.3
1.2
u/ml
0.8
1.5
1.26
19
182
(3007853) Bacteria identified in Skin by Aerobe culture
32
262
1.25
0.51
1.5
1.6
—
—
—
0
0
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
65
573
1.17
0.49
1.5
1.4
—
—
—
0
0
(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay
7
45
1.57
0.49
1.3
1.4
—
—
—
0
0
(40760888) Immunoglobulin light chains.free panel - Serum
7
45
1.57
0.49
7.1
3.7
—
—
—
0
0
(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay
7
45
1.57
0.49
1.3
1.4
—
—
—
0
0
(3045424) Erythrocytes [Presence] in Urine
7
46
1.53
0.48
1.0
1.5
—
—
—
0
0
(40761535) Cells panel - Urine sediment
16
210
0.75
0.48
4.6
3.4
—
—
—
0
0
(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma
7
47
1.50
0.48
1.1
1.3
—
—
—
0
0
(3016879) Cocaine [Presence] in Urine
10
68
1.49
0.47
1.2
1.3
—
—
—
0
0
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
47
406
1.19
0.46
3.0
2.7
e6/l
2.2
1.0
0.43
27
220
(36660697) Celiac disease serology panel - Serum
27
220
1.25
0.45
1.1
1.2
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
12
163
0.73
0.45
4.8
2.0
—
—
—
0
0
(3011288) Drugs identified in Urine by Screen method
7
51
1.38
0.44
1.3
1.6
—
—
—
0
0
(3008152) Bicarbonate [Moles/volume] in Arterial blood
9
130
0.68
0.44
4.6
7.0
mmol/l
24.0
25.0
—
9
122
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
8
56
1.44
0.43
1.1
1.4
—
—
—
0
0
(3019309) Folate [Moles/volume] in Red Blood Cells
52
457
1.17
0.42
1.7
1.7
nmol/l
903.3
1233.1
2.27
37
346
(3025941) Bacteria identified in Stool by Culture
13
172
0.75
0.42
1.5
1.2
—
—
—
0
0
(4027681)
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
(3000081) cloZAPine [Moles/volume] in Serum or Plasma
0
16
0.00
0.41
0.0
19.9
—
1640.1
—
0
16
(3008832) Norclozapine [Moles/volume] in Serum or Plasma
0
16
0.00
0.41
0.0
13.5
—
837.9
—
0
16
(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection
5
34
1.48
0.40
1.2
1.4
—
—
—
0
0
(3013139) Helicobacter pylori Ag [Presence] in Stool
23
187
1.25
0.40
1.3
1.3
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
105
973
1.12
0.39
7.6
7.6
inr
1.2
1.2
0.04
27
304
(3024980) IgG subclass 4 [Mass/volume] in Serum
5
35
1.44
0.39
1.8
1.3
g/l
0.8
0.5
—
5
30
(3007368) IgG [Mass/volume] in Cerebral spinal fluid
0
19
0.00
0.39
0.0
1.1
—
27.1
—
0
14
(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection
0
19
0.00
0.39
0.0
1.5
—
—
—
0
0
(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
(3018095) Leukocytes [#/volume] in Urine
84
914
0.89
0.38
4.6
3.6
e6/l
107.1
87.0
0.16
60
639
(3027801) Oxygen [Partial pressure] in Arterial blood
28
235
1.21
0.37
2.8
6.6
kpa
11.2
12.2
0.48
28
226
(3027946) Carbon dioxide [Partial pressure] in Arterial blood
28
235
1.21
0.37
2.8
6.6
kpa
5.4
5.2
0.46
28
226
(3030467) Casts [#/volume] in Urine by Automated count
63
697
0.88
0.37
3.8
2.9
e6/l
0.3
0.4
0.31
44
525
(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma
10
72
1.40
0.37
1.8
1.4
—
—
—
0
0
(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight
10
72
1.40
0.37
1.8
1.4
—
—
—
0
0
(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age
10
72
1.40
0.37
1.8
1.4
—
—
—
0
0
(3024891) Influenza virus A+B Ag [Presence] in Specimen
10
72
1.40
0.37
1.2
1.2
—
—
—
0
0
(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma
10
72
1.40
0.37
1.8
1.4
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
53
591
0.88
0.35
3.6
3.7
—
—
—
0
0
(21494755) Public health laboratory ask at order entry panel
30
256
1.19
0.35
1.3
1.3
—
—
—
0
0
(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum
14
109
1.30
0.34
1.2
1.1
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
62
681
0.89
0.33
3.7
2.8
—
—
—
0
0
(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis
6
89
0.67
0.33
3.3
2.0
g/l
8.4
10.3
—
6
83
(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma
60
544
1.13
0.32
1.5
1.7
pmol/l
173585335.2
439.7
0.49
53
457
(3007164) IgA [Mass/volume] in Serum or Plasma
60
544
1.13
0.32
1.3
1.4
g/l
2.0
2.3
1.28
32
327
(44816559) Phosphatidylethanol [Mass/volume] in Blood
6
47
1.28
0.32
1.3
1.1
—
—
—
0
0
(3022621) pH of Urine by Test strip
20
165
1.23
0.32
5.3
2.8
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
66
603
1.12
0.32
3.8
3.7
—
—
—
0
0
(3019150) Specific gravity of Urine by Refractometry
51
565
0.88
0.31
5.5
3.9
kg/l
1.0
1.0
0.95
15
84
(3004716) Salmonella sp identified in Stool by Organism specific culture
13
164
0.78
0.31
1.1
1.3
—
—
—
0
0
(3021879) Hepatitis B virus core Ab [Presence] in Serum
20
166
1.22
0.30
1.6
1.3
—
—
—
0
0
(3028300) Cannabinoids [Presence] in Urine
10
75
1.34
0.30
1.2
1.3
—
—
—
0
0
(3027008) Opiates [Presence] in Urine
10
75
1.34
0.30
1.2
1.3
—
—
—
0
0
(3000764) Benzodiazepines [Presence] in Urine
10
75
1.34
0.30
1.2
1.3
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
13
102
1.29
0.30
2.8
7.0
—
—
—
0
0
(3027944) Amphetamines [Presence] in Urine
10
76
1.33
0.28
1.2
1.3
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
73
677
1.10
0.27
1.5
1.5
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
35
310
1.15
0.27
1.3
1.3
—
—
—
0
0
(3007566) Smooth muscle Ab [Titer] in Serum
8
65
1.24
0.27
1.0
1.1
—
82.0
—
0
5
(3034860) Kappa light chains.free [Mass/volume] in Serum
8
65
1.24
0.27
6.5
3.1
mg/l
48.0
61.3
—
8
52
(3047169) Lambda light chains.free [Mass/volume] in Serum or Plasma
8
65
1.24
0.27
6.5
3.1
mg/l
35.4
27.4
—
8
51
(3003338) MCHC [Mass/volume]
223
2174
1.09
0.26
20.5
16.7
g/l
331.5
331.4
0.04
223
2160
(3037522) Nuclear Ab [Titer] in Serum
42
378
1.13
0.26
1.5
1.3
titre
734.5
528.1
0.37
11
89
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
5
73
0.68
0.26
1.4
1.2
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
9
73
1.24
0.25
1.1
1.2
—
—
—
0
0
(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma
9
76
1.19
0.25
1.8
1.5
—
—
—
0
0
(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis
6
81
0.74
0.24
7.8
2.3
g/l
5.2
0.6
—
6
76
(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay
5
38
1.32
0.23
2.2
3.2
u/ml
21.2
59.2
—
5
38
(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood
11
88
1.26
0.23
2.9
4.7
%
1.3
1.5
1.01
11
82
(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection
5
40
1.25
0.22
1.2
1.4
—
—
—
0
0
(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay
5
40
1.25
0.22
1.0
1.2
—
—
—
0
0
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
5
42
1.19
0.21
1.2
1.4
—
—
—
0
0
(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay
5
42
1.19
0.21
2.0
1.7
—
—
—
0
0
(3003327) Ova and parasites identified in Stool by Light microscopy
12
98
1.23
0.21
2.3
1.6
—
—
—
0
0
(44806420)
0
11
0.00
0.21
0.0
2.7
—
—
—
0
0
(3009550) Parvovirus B19 IgG Ab [Titer] in Serum
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(3037692) Legionella sp identified in Specimen by Organism specific culture
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma
0
10
0.00
0.21
0.0
1.3
—
110.4
—
0
10
(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay
0
10
0.00
0.21
0.0
1.6
—
101.9
—
0
10
(3035933) Granulocytes/100 leukocytes in Blood
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood
0
12
0.00
0.21
0.0
4.1
—
—
—
0
0
(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood
0
12
0.00
0.21
0.0
4.1
—
—
—
0
0
(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
21
240
0.87
0.21
1.5
1.7
—
—
—
0
0
(3030905) Polymorphonuclear cells [#/volume] in Blood
5
43
1.17
0.21
2.0
2.2
e9/l
4.3
5.0
—
5
43
(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma
0
13
0.00
0.21
0.0
2.2
—
101.5
—
0
13
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
6
48
1.25
0.20
1.2
1.3
—
—
—
0
0
(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
(3022313) Gas panel - Capillary blood
12
99
1.22
0.20
4.3
2.7
—
—
—
0
0
(3050129) First trimester maternal screen panel - Serum or Plasma
11
90
1.23
0.19
1.9
1.4
—
—
—
0
0
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
6
52
1.16
0.19
1.0
1.4
—
—
—
0
0
(3013290) Carbon dioxide [Partial pressure] in Blood
6
52
1.16
0.19
1.8
2.9
kpa
5.0
5.0
—
6
52
(3027315) Oxygen [Partial pressure] in Blood
6
52
1.16
0.19
1.8
2.9
kpa
8.1
8.7
—
6
52
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
26
233
1.13
0.18
1.7
1.7
—
—
—
0
0
(3023939) Sjogrens syndrome-A extractable nuclear Ab [Units/volume] in Serum
7
60
1.17
0.18
1.0
1.2
—
47.1
—
0
6
(1001926) Buprenorphine [Presence] in Urine by Screen method
7
61
1.15
0.17
1.3
1.3
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
97
1012
0.94
0.17
4.8
3.9
—
—
—
0
0
(3016502) Oxygen saturation in Arterial blood
23
205
1.13
0.17
3.1
6.9
%
95.2
95.5
0.09
23
199
(3008898) HLA-B27 [Presence]
11
130
0.84
0.16
1.1
1.1
—
—
—
0
0
(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis
6
79
0.75
0.15
3.3
2.1
g/l
36.8
38.0
—
6
73
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
10
83
1.21
0.15
1.7
1.8
—
—
—
0
0
(4034850)
9
78
1.16
0.15
12.2
9.3
—
—
—
0
0
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
28
306
0.91
0.15
1.8
2.0
—
—
—
0
0
(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma
9
81
1.11
0.15
1.6
1.9
—
—
—
0
0
(3045414) Leukocytes [Presence] in Urine
13
112
1.17
0.14
2.0
1.8
—
—
—
0
0
(3019060) Gas panel - Arterial blood
11
127
0.86
0.12
2.6
4.1
—
—
—
0
0
(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)
23
210
1.10
0.12
3.2
2.7
ml/min/173m2
71.1
68.3
0.13
11
82
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
27
249
1.09
0.12
2.8
3.2
—
—
—
0
0
(40768443) Skin Pathology biopsy report
13
114
1.15
0.12
1.2
1.2
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
77
742
1.05
0.11
4.4
3.4
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
127
1301
0.96
0.11
4.2
3.7
estimate
0.0
0.0
0.00
18
264
(3021589) Normoblasts [#/volume] in Blood
118
1150
1.04
0.11
10.0
8.9
e9/l
0.0
0.0
0.56
97
950
(3002173) Hemoglobin [Mass/volume] in Arterial blood
21
193
1.09
0.10
3.2
7.1
g/l
123.6
120.7
0.28
21
187
(46235355) HIV 1 and 2 tests - Meaningful Use set
47
448
1.06
0.10
1.9
1.8
—
—
—
0
0
(3032035) Polymorphonuclear cells/100 leukocytes in Blood
5
45
1.11
0.10
2.8
2.6
%
59.4
58.7
—
5
45
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
16
176
0.90
0.09
1.3
1.5
—
—
—
0
0
(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum
10
87
1.15
0.09
1.2
1.4
miu/ml
392.7
221.4
—
5
44
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
70
724
0.96
0.09
1.8
1.6
mmol/l
1.3
1.4
0.54
61
615
(4010399)
18
196
0.91
0.09
1.5
1.5
—
—
—
0
0
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
15
136
1.11
0.08
2.8
2.3
—
—
—
0
0
(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture
6
56
1.07
0.08
1.2
1.7
—
—
—
0
0
(3007930) Methemoglobin/Hemoglobin.total in Blood
10
88
1.14
0.08
3.0
4.8
%
0.7
0.9
—
10
83
(3023511) Choriogonadotropin [Units/volume] in Urine
7
65
1.08
0.08
1.0
1.2
—
—
—
0
0
(3052851) Hemolysis interference index of Serum or Plasma
8
75
1.07
0.07
4.5
2.9
—
—
—
0
0
(3049717) Cytology report of Urine Cyto stain
8
76
1.05
0.07
2.0
2.9
—
—
—
0
0
(3020891) Body temperature
7
85
0.82
0.07
4.0
4.0
—
—
—
0
0
(40768793) Breast Pathology biopsy report
8
92
0.87
0.07
1.1
1.3
—
—
—
0
0
(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
8
95
0.84
0.06
2.9
1.9
g/l
6.8
7.5
—
8
79
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
8
95
0.84
0.06
2.9
1.9
—
—
—
0
0
(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
8
95
0.84
0.06
2.9
1.9
g/l
6.1
3.8
—
8
76
(3014765) Yersinia sp identified in Stool by Organism specific culture
9
100
0.90
0.06
1.1
1.1
—
—
—
0
0
(42529406) Shigella sp [Presence] in Stool by Culture
9
102
0.88
0.06
1.1
1.1
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
26
274
0.94
0.06
1.7
1.8
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
16
149
1.08
0.05
1.6
1.4
—
—
—
0
0
(3021601) Nitrite [Presence] in Urine by Test strip
129
1308
0.98
0.05
6.3
5.1
estimate
0.0
0.0
0.50
19
260
(3017143) Hepatitis C virus Ab [Presence] in Serum
28
269
1.04
0.04
1.8
1.4
—
—
—
0
0
(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma
25
240
1.05
0.03
2.6
2.3
u/l
132.4
32.8
0.60
20
203
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
10
92
1.09
0.03
1.2
2.0
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
88
892
0.98
0.03
4.4
3.0
—
—
—
0
0
(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum
19
198
0.96
0.02
1.9
2.4
—
8.6
—
0
6
(3022145) Colonoscopy Study observation
31
318
0.97
0.02
1.3
1.3
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
37
378
0.98
0.01
1.9
1.6
—
—
—
0
0
(3044889) 12 lead EKG panel
177
1778
0.99
0.01
3.6
3.7
—
—
—
0
0
(3026782) Osmolality of Urine
49
497
0.98
0.01
3.7
2.7
mosm/kgh2o
531.1
542.0
0.11
43
428
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
54
533
1.02
0.01
1.4
1.3
u/ml
1.1
14.7
4.45
16
216
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
14
134
1.05
0.00
1.3
1.8
—
—
—
0
0
(1002224) Polysomnography panel
11
112
0.98
0.00
1.1
1.1
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
16
157
1.02
0.00
1.6
1.5
—
—
—
0
0
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
18
177
1.02
0.00
1.4
1.9
—
—
—
0
0
(3015171) Extractable nuclear Ab [Units/volume] in Serum
10
105
0.95
0.00
1.0
1.3
—
1.5
—
0
7
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
15
145
1.04
0.00
1.0
1.0
—
—
—
0
0
(3020630) Protein [Mass/volume] in Serum or Plasma
18
185
0.97
0.00
2.9
2.4
g/l
68.3
67.4
0.19
18
166
(3002582) Erythrocytes [#/volume] in Urine
75
754
0.99
0.00
4.1
3.1
e6/l
16.8
130.5
0.73
55
579
(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma
27
266
1.02
0.00
1.7
4.0
ug/l
2.7
49.2
0.90
21
218
(42868766) Dientamoeba fragilis DNA [Presence] in Stool by NAA with probe detection
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(4198724)
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate
0
9
0.00
0.00
0.0
8.1
—
—
—
0
0
(37020300) Entamoeba histolytica DNA [Presence] in Stool by NAA with probe detection
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(3008536) Aspergillus sp Ab [Presence] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
8
88
0.91
0.00
2.9
2.0
g/l
2.3
3.1
—
8
77
(42868415) European tick borne encephalitis virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3005033) Fetal Nuchal fold Thickness US
6
61
0.98
0.00
1.8
1.4
—
—
—
0
0
(44806071)
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3031072) Herpes simplex virus 1 IgG Ab [Presence] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
9
98
0.92
0.00
1.1
1.1
—
—
—
0
0
(3022689) Creatine [Moles/volume] in Urine
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3043238) Trisomy 21 risk [Likelihood] in Fetus
6
65
0.92
0.00
1.8
1.5
—
—
—
0
0
(3024471) HLA-A [Type]
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3005880) Parainfluenza virus 3 Ag [Presence] in Specimen
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3014051) Protein [Presence] in Urine by Test strip
5
56
0.89
0.00
3.2
2.1
—
—
—
0
0
(3019083) Insulin-like growth factor [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3003129) Base excess in Capillary blood by calculation
0
5
0.00
0.00
0.0
1.0
—
3.8
—
0
5
(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3005011) Chlamydia sp Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma
13
130
1.00
0.00
1.7
1.5
—
—
—
0
0
(3001684) Respiratory syncytial virus Ag [Presence] in Specimen
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(42868499) Enterovirus IgG Ab [Presence] in Cerebral spinal fluid by Immunoassay
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3007695) Herpes simplex virus 2 IgG Ab [Presence] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3013293) Extractable nuclear Ab [Presence] in Serum
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3000285) Sodium [Moles/volume] in Blood
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
5
59
0.84
0.00
1.4
1.8
—
—
—
0
0
(3018851) Theophylline [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.4
—
36.6
—
0
5
(3039602) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Capillary blood
0
6
0.00
0.00
0.0
2.0
—
1.2
—
0
6
(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(40763634) TCRG gene rearrangements [Presence] in Bone marrow by Molecular genetics method
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3047352) Trisomy 18 risk [Likelihood] in Fetus
6
61
0.98
0.00
1.8
1.4
—
—
—
0
0
(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3021578) Parainfluenza virus 2 Ag [Presence] in Specimen
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum
17
170
1.00
0.00
1.1
1.3
—
44.1
—
0
7
(40765096) Chromosome analysis panel by Banding
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3001964) Herpes simplex virus Ag [Presence] in Specimen
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3002619) Bacteria identified in Specimen by Culture
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(42868417) European tick borne encephalitis virus IgG Ab [Presence] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3010464) Parainfluenza virus 1 Ag [Presence] in Specimen
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(21494814) CD8 cells/100 lymphocytes in Specimen
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
(3012110) Lysozyme [Mass/volume] in Serum or Plasma
6
66
0.91
0.00
1.0
2.5
mg/l
13.9
11.2
—
6
60
(3009261) Glucose [Presence] in Urine by Test strip
132
1320
1.00
0.00
4.5
3.8
estimate
0.0
0.0
0.50
19
254
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYTOXNOD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXNOD | 1.287 [1.09, 1.53] | 0.004 |
| Birth year | 0.996 [0.99, 1.0] | 0.403 |
During the follow-up period (1.1.1998 — 31.12.2019), 211 out of 1340 females with E4_THYTOXNOD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXNOD | 1.204 [0.89, 1.62] | 0.223 |
| Birth year | 0.987 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 68 out of 290 males with E4_THYTOXNOD died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYTOXNOD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.172% | 0.275% |
| 5 | 0.855% | 1.442% |
| 10 | 2.072% | 3.605% |
| 15 | 3.994% | 6.787% |
| 20 | 6.997% | 11.648% |
Relationships between endpoints
↥Index endpoint: E4_THYTOXNOD – Thyrotoxicosis with toxic single thyroid nodule
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data