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Other and unspecified disorders of adult personality and behaviour

DOID EFO Endpoint Browser PheWeb

F5_PERSOTH

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F68, F69
  • Cause of death: ICD-10 — F68, F69

2 out of 7 registries used, show all original rules.

219

4. Check minimum number of events

None

219

5. Include endpoints

None

219

6. Filter based on genotype QC (FinnGen only)

219

Control definitions (FinnGen only)

Control exclude
F5_PERSOBEH

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2012 998 1001
Only index persons 1845 947 898
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.03 0.03 0.03
Median age at first event (years)
Whole population 30.95 30.95 30.80
Only index persons 29.81 29.99 29.62

-FinnGen-

Key figures

All Female Male
Number of individuals 219 146 73
Unadjusted period prevalence (%) 0.04 0.05 0.03
Median age at first event (years) 34.26 32.63 37.52

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
200
Matched controls
1998
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F69
ICD-10 Finland
Unspecified disorder of adult personality and behaviour
+∞
132.5
112
*
N05AH04
ATC
quetiapine; oral
13.1
54.8
117
194
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
44.1
52.1
64
21
T36
ICD-10 Finland
Poisoning by systemic antibiotics
31.0
51.8
70
34
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
263.9
42.7
42
*
F60.9
ICD-10 Finland
Personality disorder, unspecified
+∞
41.1
38
*
F61.0
ICD-10 Finland
Mixed personality disorders
248.2
40.4
40
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
10.2
40.4
93
157
F68.1
ICD-10 Finland
Intentional production or feigning of symptoms or disabilities, either physical or psychological [factitious disorder]
+∞
39.9
37
*
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
15.2
39.9
70
68
F68.8
ICD-10 Finland
Other specified disorders of adult personality and behaviour
+∞
38.8
36
*
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
12.0
38.0
76
97
N05AH03
ATC
olanzapine; systemic
15.7
37.3
64
58
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
430.7
37.3
36
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
13.4
36.5
68
74
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
10.6
36.3
78
113
N06AX11
ATC
mirtazapine; oral
7.1
35.6
121
356
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
18.1
35.6
57
43
N03AG01
ATC
valproic acid; systemic, rectal
15.0
35.5
62
58
N05AA02
ATC
levomepromazine; systemic
35.8
35.2
45
16
N03AX09
ATC
lamotrigine; oral
18.5
34.7
55
40
N05BA01
ATC
diazepam; systemic, rectal
9.5
31.6
72
112
N06AX16
ATC
venlafaxine; oral
7.9
30.6
81
159
N05AX08
ATC
risperidone; systemic
14.0
29.9
53
50
N06AB06
ATC
sertraline; oral
8.4
27.3
66
110
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
15.8
27.0
45
36
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
12.4
26.8
50
52
F29
ICD-10 Finland
Unspecified nonorganic psychosis
14.2
26.4
46
41
N05AB03
ATC
perphenazine; systemic, rectal
27.9
25.8
35
15
N06AB04
ATC
citalopram; systemic
5.9
24.6
82
210
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
+∞
24.5
23
*
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
11.0
23.8
47
54
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
26.9
23.5
32
14
F68.0
ICD-10 Finland
Elaboration of physical symptoms for psychological reasons
+∞
23.4
22
*
N05BA04
ATC
oxazepam; oral
5.2
23.3
90
270
N05CF01
ATC
zopiclone; oral
5.1
23.3
94
296
N05AX12
ATC
aripiprazole; systemic
13.0
23.3
42
40
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
7.9
23.1
57
96
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
6.9
22.8
63
125
N03AE01
ATC
clonazepam; systemic
12.6
22.4
41
40
N03AX16
ATC
pregabalin; oral
5.1
20.4
76
214
N06AB03
ATC
fluoxetine; oral
6.2
19.9
59
126
N05AF03
ATC
chlorprothixene; systemic
19.4
19.9
30
18
P29
ICPC
Psychological sympt/compl other
7.9
19.8
48
77
N06AX03
ATC
mianserin; oral
20.9
19.8
29
16
P99
ICPC
Psychological disorders other
14.9
19.8
33
26
N05AD01
ATC
haloperidol; systemic
38.6
19.4
24
7
F99
ICD-10 Finland
Mental disorder, not otherwise specified
17.4
19.2
30
20
F31.8
ICD-10 Finland
Other bipolar affective disorders
25.7
18.3
25
11
ZY010
NOMESCO Finland
Hospital outpatient
9.2
18.2
39
51
F60.8
ICD-10 Finland
Other specific personality disorders
+∞
18.0
17
*
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
9.7
17.4
36
44
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
16.1
17.4
28
20
N05BE01
ATC
buspirone; oral
17.1
17.2
27
18
N06AX12
ATC
bupropion; oral
7.3
17.2
43
72
N05CD07
ATC
temazepam; oral
7.8
17.1
41
64
N05BA06
ATC
lorazepam; systemic, sublingual
13.4
16.7
29
25
C07AA05
ATC
propranolol; systemic
4.2
16.4
73
238
N03AF02
ATC
oxcarbazepine; oral
14.7
16.2
27
21
P80
ICPC
Personality disorder
172.9
15.7
16
*
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
14.7
15.7
26
20
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
18.0
15.7
24
15
N07BB01
ATC
disulfiram; oral
8.3
15.4
35
50
N06AB10
ATC
escitalopram; oral
3.8
15.4
81
301
P76
ICPC
Depressive disorder
6.8
15.3
40
71
F39
ICD-10 Finland
Unspecified mood [affective] disorder
18.4
15.2
23
14
F20.9
ICD-10 Finland
Schizophrenia, unspecified
18.4
15.2
23
14
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
18.4
15.2
23
14
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
7.3
15.0
37
60
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
4.4
15.0
61
180
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
14.1
14.9
25
20
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
18.8
14.7
22
13
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
7.5
14.5
35
55
N05AH02
ATC
clozapine; systemic
16.1
14.5
23
16
N06AA09
ATC
amitriptyline; systemic
9.3
14.4
30
37
P01
ICPC
Feeling anxious/nervous/tense
4.2
14.4
62
193
F90.0
ICD-10 Finland
Disturbance of activity and attention
9.8
14.3
29
34
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
19.4
14.2
21
12
P74
ICPC
Anxiety disorder/anxiety state
9.5
14.1
29
35
TPH04
NOMESCO Finland
Cathetrisation of vein
4.3
14.1
58
172
F10.25
ICD-10 Finland
Alcohol dependence continuous use
26.0
14.1
19
8
Z2446
NOMESCO Finland
Social worker
7.9
13.8
32
47
S06.0
ICD-10 Finland
Concussion
5.2
13.5
44
102
N05AN01
ATC
lithium; oral
13.5
13.5
23
19
Z2445
NOMESCO Finland
Psychologist
9.6
13.3
27
32
N06AB05
ATC
paroxetine; oral
6.5
13.2
35
63
M54.5
ICD-10 Finland
Low back pain
3.2
13.1
89
396
R56.8
ICD-10 Finland
Other and unspecified convulsions
7.8
13.0
30
44
AA1AD
NOMESCO Finland
CT of head and brain
4.0
12.9
57
179
A06AD11
ATC
lactulose; oral
5.9
12.8
37
74
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
12.8
12.7
22
19
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
7.9
12.7
29
42
N03AX12
ATC
gabapentin; oral
4.4
12.4
49
138
N05BA12
ATC
alprazolam; oral
5.2
12.4
40
91
N06AX21
ATC
duloxetine; oral
4.7
12.4
44
112
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
8.9
12.3
26
33
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
19.6
12.3
18
10
ZY000
NOMESCO Finland
Hospital inpatient
23.0
12.2
17
8
F34.1
ICD-10 Finland
Dysthymia
9.9
12.1
24
27
N06AX05
ATC
trazodone; oral
12.9
12.1
21
18
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
16.0
12.1
19
13
L28
ICPC
Limited function/disability (L)
5.4
11.9
37
81
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
32.2
11.8
15
5
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.9
11.6
98
493
N02AA05
ATC
oxycodone; systemic
6.6
11.6
30
52
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
5.5
11.6
35
74
F10.20
ICD-10 Finland
Alcohol dependence currently independent
16.3
11.5
18
12
XF400
NOMESCO Finland
ECG with 12 standard connections
4.6
11.5
42
109
F33.8
ICD-10 Finland
Other recurrent depressive disorders
37.4
11.4
14
*
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
13.8
11.4
19
15
N03AX11
ATC
topiramate; oral
12.2
11.3
20
18
P72
ICPC
Schizophrenia
12.2
11.3
20
18
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
11.0
11.3
21
21
P03
ICPC
Feeling depressed
4.0
11.1
48
147
Z3231
NOMESCO Finland
Registered nurse
3.2
11.1
70
289
N05CD02
ATC
nitrazepam; oral
46.0
11.1
13
*
R06.0
ICD-10 Finland
Dyspnoea
3.5
11.0
58
208
N05BA02
ATC
chlordiazepoxide; systemic
29.9
10.9
14
5
F19.1
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use
29.9
10.9
14
5
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
23.0
10.9
15
7
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
15.3
10.7
17
12
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.7
10.6
50
164
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.1
10.6
34
77
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
13.0
10.6
18
15
F61
ICD-10 Finland
Mixed and other personality disorders
115.8
10.5
11
*
T50.9
ICD-10 Finland
Poisoning: Other and unspecified drugs, medicaments and biological substances
34.5
10.5
13
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.9
10.3
84
404
R05
ICPC
Cough
3.2
10.3
62
243
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
10.0
10.3
20
22
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
10.9
10.3
19
19
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
6.3
10.3
27
48
R21
ICPC
Throat symptom/complaint
3.0
10.2
75
336
J45.9
ICD-10 Finland
Asthma, unspecified
3.6
10.2
50
169
C03CA01
ATC
furosemide; systemic
4.1
10.1
41
118
R51.80
ICD-10 Finland
Headache
3.5
10.1
53
188
N03AF01
ATC
carbamazepine; oral, rectal
9.5
10.1
20
23
X78
ICD-10 Finland
Intentional self-harm by sharp object
21.4
9.9
14
7
Z01.8
ICD-10 Finland
Other specified special examinations
3.4
9.9
54
198
F10.09
ICD-10 Finland
Alcohol intoxication UNS
14.4
9.9
16
12
R55
ICD-10 Finland
Syncope and collapse
5.1
9.8
31
69
K59.09
ICD-10 Finland
Constipation, unspecified
9.9
9.8
19
21
IGY02
NOMESCO Finland
Psychiatric monitoring contact
9.9
9.8
19
21
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
12.3
9.8
17
15
M79.6
ICD-10 Finland
Pain in limb
2.7
9.7
85
425
L03
ICPC
Low back symptom/complaint
3.0
9.7
68
296
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.0
9.7
31
70
R11
ICD-10 Finland
Nausea and vomiting
5.0
9.7
31
70
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
16.1
9.7
15
10
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
4.6
9.7
34
85
N05AB01
ATC
dixyrazine; systemic
31.7
9.5
12
*
F10.24
ICD-10 Finland
Alcohol depence active use
23.0
9.5
13
6
N02AX02
ATC
tramadol; systemic, rectal
2.7
9.4
89
463
2968A
ICD-9 Finland
Affective psychoses, Manic-depressive psychosis, other and unspecified
+∞
9.4
9
*
F60.0
ICD-10 Finland
Paranoid personality disorder
+∞
9.4
9
*
F33.4
ICD-10 Finland
Recurrent depressive disorder, currently in remission
8.4
9.4
20
26
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.2
9.4
55
212
G43.9
ICD-10 Finland
Migraine, unspecified
4.8
9.3
31
73
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
4.7
9.3
32
78
F41.8
ICD-10 Finland
Other specified anxiety disorders
7.7
9.3
21
30
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.8
9.2
31
74
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.8
9.2
40
122
SPAT1254
SPAT
Administration of medicine
3.6
9.2
43
140
XF600
NOMESCO Finland
Bloodpressure measurement
6.5
9.1
23
39
F50.9
ICD-10 Finland
Eating disorder, unspecified
19.7
9.1
13
7
N05AA01
ATC
chlorpromazine; systemic, rectal
25.4
9.0
12
5
A03FA01
ATC
metoclopramide; systemic, rectal
3.3
9.0
50
185
SPAT1222
SPAT
Counselling/guidance promoting independent living
4.2
8.9
34
92
N05CF02
ATC
zolpidem; oral
3.2
8.9
50
187
TKC20
NOMESCO Finland
Catheterisation of bladder
8.3
8.9
19
25
P06
ICPC
Sleep disturbance
4.1
8.9
35
98
G40.9
ICD-10 Finland
Epilepsy, unspecified
8.9
8.8
18
22
UKC02
NOMESCO Finland
Cystoscopy
4.5
8.8
31
78
F45.0
ICD-10 Finland
Somatization disorder
52.3
8.8
10
*
F19.24
ICD-10 Finland
Addiction relationship caused by several drugs in combination and by other psychoactive substances active addiction
52.3
8.8
10
*
N05AD03
ATC
melperone; systemic
52.3
8.8
10
*
R53
ICD-10 Finland
Malaise and fatigue
3.0
8.7
57
234
S29
ICPC
Skin symptom/complaint other
3.5
8.7
43
146
A02BA02
ATC
ranitidine; systemic
3.5
8.7
43
146
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
17.2
8.7
13
8
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
17.2
8.7
13
8
103
Kela drug reimbursment
Diabetes, insulin-treated
3.3
8.7
47
170
WX892
NOMESCO Finland
Monitored bed care
5.8
8.6
24
46
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.7
8.6
39
123
S18
ICPC
Laceration/cut
2.6
8.6
86
454
J01FF01
ATC
clindamycin; systemic
2.8
8.6
65
294
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
8.5
8.6
18
23
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
28.9
8.6
11
*
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
28.9
8.6
11
*
F44.9
ICD-10 Finland
Dissociative [conversion] disorder, unspecified
28.9
8.6
11
*
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
2.4
8.6
122
780
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
7.7
8.5
19
27
F60.2
ICD-10 Finland
Dissocial personality disorder
+∞
8.4
8
*
3018D
ICD-9 Finland
Personality disorders, Other personality disorders[EPÄVAKAA PERSOONALLISUUS]
+∞
8.4
8
*
R52.9
ICD-10 Finland
Pain, unspecified
4.9
8.3
27
62
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
15.3
8.3
13
9
A46
ICD-10 Finland
Erysipelas
4.4
8.3
30
77
T90
ICPC
Diabetes non-insulin dependent
3.5
8.2
40
134
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
5.6
8.2
23
45
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
34.9
8.2
10
*
3018X
ICD-9 Finland
Personality disorders, Other personality disorders[MUU TAI SEKAMUOTOINEN PERSOONALLISUUSHÄIRIÖ]
34.9
8.2
10
*
E950A
ICD-9 Finland
Suicide and self-inflicted poisoning by solid or liquid substances
34.9
8.2
10
*
A04
ICPC
Weakness/tiredness general
3.5
8.1
39
129
W0A12
NOMESCO Finland
Planned therapy visit for psychiatric disease
23.1
8.1
11
5
R03BB04
ATC
tiotropium bromide; inhalant
6.2
8.1
21
37
K10.3
ICD-10 Finland
Alveolitis of jaws
5.3
8.1
24
50
N06AA12
ATC
doxepin; systemic
8.3
8.1
17
22
F51.0
ICD-10 Finland
Nonorganic insomnia
3.2
8.0
45
167
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.7
8.0
35
107
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.7
8.0
36
113
F41.1
ICD-10 Finland
Generalized anxiety disorder
4.6
8.0
27
65
SPAT1240
SPAT
Therapeutic discussion
3.3
8.0
43
154
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.0
7.9
25
56
R42
ICD-10 Finland
Dizziness and giddiness
3.1
7.9
45
169
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
5.4
7.9
23
47
R02
ICPC
Shortness of breath/dyspnoea
3.9
7.9
32
92
F33.1
ICD-10 Finland
Recurrent depressive disorder, current episode moderate
8.0
7.9
17
23
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.5
7.8
37
121
N04AA02
ATC
biperiden; systemic
15.8
7.8
12
8
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
15.8
7.8
12
8
F19.20
ICD-10 Finland
Addiction relationship caused by several drugs in combination and by other psychoactive substances currently independent
46.8
7.8
9
*
N06AX26
ATC
vortioxetine; oral
4.7
7.8
26
62
X59
ICD-10 Finland
Exposure to unspecified factor
2.9
7.7
53
224
SAA01
NOMESCO Finland
Simple examination of mouth
2.7
7.7
163
1243
K02.1
ICD-10 Finland
Caries of dentine
2.4
7.7
140
986
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
12.5
7.7
13
11
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
12.5
7.7
13
11
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
12.5
7.7
13
11
R10.1
ICD-10 Finland
Pain localized to upper abdomen
3.2
7.7
43
159
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
19.3
7.7
11
6
215
Kela drug reimbursment
Diabetes, non-insulin-treated
3.1
7.7
44
166
L17
ICPC
Foot/toe symptom/complaint
2.8
7.7
57
251
A01
ICPC
Pain general/multiple sites
4.6
7.6
26
63
P98
ICPC
Psychosis NOS/other
26.1
7.6
10
*
ZXA05
NOMESCO Finland
Left side
2.9
7.6
52
218
A02BC01
ATC
omeprazole; systemic
2.6
7.6
62
290
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
3.1
7.6
45
171
P01AB01
ATC
metronidazole; oral, rectal
2.4
7.6
93
539
N06AG02
ATC
moclobemide; oral
8.2
7.5
16
21
S61.9
ICD-10 Finland
Open wound of wrist and hand, part unspecified
8.2
7.5
16
21
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
4.5
7.5
26
64
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
5.6
7.5
21
41
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
14.1
7.5
12
9
N06AB08
ATC
fluvoxamine; oral
14.1
7.5
12
9
Z72.8
ICD-10 Finland
Other problems related to lifestyle
83.0
7.5
8
*
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
83.0
7.5
8
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.2
7.4
22
46
F60.7
ICD-10 Finland
Dependent personality disorder
+∞
7.3
7
*
P28
ICPC
Limited function/disability (P)
16.5
7.3
11
7
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
5.7
7.3
20
38
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
5.1
7.3
22
47
EBA00
NOMESCO Finland
Extraction of tooth
2.3
7.3
84
472
R33
ICD-10 Finland
Retention of urine
6.5
7.3
18
30
R07.4
ICD-10 Finland
Chest pain, unspecified
2.7
7.3
53
232
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
5.3
7.2
21
43
SPAT1104
SPAT
Monitoring of emergency patient
5.3
7.2
21
43
Z3229
NOMESCO Finland
Other healthcare associate professional
4.5
7.2
25
62
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
3.5
7.2
34
111
P19
ICPC
Drug abuse
20.9
7.2
10
5
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
7.1
59
276
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.6
7.1
57
264
A02BC02
ATC
pantoprazole; systemic
2.3
7.1
125
850
B18.2
ICD-10 Finland
Chronic viral hepatitis C
14.4
7.0
11
8
183
Kela drug reimbursment
Lamotrigin and topiramate
14.4
7.0
11
8
L08.9
ICD-10 Finland
Local infection of skin and subcutaneous tissue, unspecified
8.8
6.9
14
17
SPAT1307
SPAT
Psychosocial counselling and guidance
3.6
6.9
31
97
J45.0
ICD-10 Finland
Predominantly allergic asthma
3.4
6.9
33
109
J46
ICD-10 Finland
Status asthmaticus
9.8
6.9
13
14
A10AE04
ATC
insulin glargine; parenteral
4.4
6.9
24
60
X58
ICD-10 Finland
Exposure to other specified factors
3.0
6.9
42
164
Z72.2
ICD-10 Finland
Drug use
17.4
6.8
10
6
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
17.4
6.8
10
6
F21
ICD-10 Finland
Schizotypal disorder
41.5
6.8
8
*
Z04.4
ICD-10 Finland
Examination and observation following alleged rape and seduction
41.5
6.8
8
*
R52.2
ICD-10 Finland
Other chronic pain
6.3
6.8
17
29
N06AX22
ATC
agomelatine; oral
8.3
6.7
14
18
A07AA09
ATC
vancomycin; oral
23.4
6.7
9
*
F20.09
ICD-10 Finland
Paranoid schizophrenia UNS
23.4
6.7
9
*
R96
ICPC
Asthma
4.0
6.7
26
72
K92.0
ICD-10 Finland
Haematemesis
12.8
6.7
11
9
F43.20
ICD-10 Finland
Adaptation disorder with short-term depression
12.8
6.7
11
9
F93.89
ICD-10 Finland
Other childhood emotional disorders
12.8
6.7
11
9
Z53.2
ICD-10 Finland
Procedure not carried out because of patient's decision for other and unspecified reasons
12.8
6.7
11
9
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.8
6.6
27
78
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
5.0
6.6
20
43
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
6.1
6.6
17
30
N06BA04
ATC
methylphenidate; oral
6.6
6.6
16
26
G44.2
ICD-10 Finland
Tension-type headache
3.0
6.6
40
154
J01MA12
ATC
levofloxacin; systemic
3.2
6.6
36
129
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
5.3
6.6
19
39
A10BA02
ATC
metformin; oral
2.8
6.5
43
176
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
5.9
6.5
17
31
F44.7
ICD-10 Finland
Mixed dissociative [conversion] disorders
72.0
6.5
7
*
IAB07
NOMESCO Finland
Consultation concerning a patient with self-harm intention
72.0
6.5
7
*
F60.1
ICD-10 Finland
Schizoid personality disorder
72.0
6.5
7
*
Z71.8
ICD-10 Finland
Other specified counselling
2.4
6.5
64
330
C08DA01
ATC
verapamil; systemic
8.6
6.4
13
16
R50.9
ICD-10 Finland
Fever, unspecified
3.1
6.4
36
133
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
11.5
6.4
11
10
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
6.4
97
607
Z2221
NOMESCO Finland
Medical doctor
2.3
6.3
67
356
XKD00
NOMESCO Finland
Uroflowmetry
4.2
6.3
23
60
A28
ICPC
Limited function/disability NOS
3.8
6.3
26
76
F22.0
ICD-10 Finland
Delusional disorder
18.7
6.3
9
5
N05AF01
ATC
flupentixol; systemic
18.7
6.3
9
5
F41.09
ICD-10 Finland
UNS Panic Syndrome
6.1
6.3
16
28
J04AB02
ATC
rifampicin; systemic
+∞
6.3
6
*
N06AX17
ATC
milnacipran; oral
27.6
6.3
8
*
N06AA22
ATC
NA
27.6
6.3
8
*
A41.9
ICD-10 Finland
Sepsis, unspecified
8.1
6.2
13
17
J01EA01
ATC
trimethoprim; systemic
2.4
6.2
56
274
P15
ICPC
Chronic alcohol abuse
7.1
6.2
14
21
R81
ICPC
Pneumonia
9.0
6.1
12
14
A04AA01
ATC
ondansetron; systemic, rectal
4.6
6.1
20
47
R00.0
ICD-10 Finland
Tachycardia, unspecified
6.4
6.1
15
25
G43.3
ICD-10 Finland
Complicated migraine
10.5
6.1
11
11
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.3
6.1
63
328
L08
ICPC
Shoulder symptom/complaint
2.8
6.1
39
158
L15
ICPC
Knee symptom/complaint
2.6
6.0
46
204
G47.3
ICD-10 Finland
Sleep apnoea
2.8
6.0
41
171
S22
ICPC
Nail symptom/complaint
5.4
6.0
17
34
J01MA02
ATC
ciprofloxacin; systemic
2.2
6.0
73
409
NA1AD
NOMESCO Finland
Cervical spine CT examination
7.6
6.0
13
18
L08.8
ICD-10 Finland
Other specified local infections of skin and subcutaneous tissue
7.6
6.0
13
18
H03AA01
ATC
levothyroxine sodium; systemic
2.5
6.0
51
241
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
3.0
6.0
35
133
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.3
6.0
21
53

Mortality – FinRegistry

↥

Association

Association between endpoint F5_PERSOTH and mortality.

Females

Parameter HR [95% CI] p-value
F5_PERSOTH 3.96 [2.86, 5.48] < 0.001
Birth year 0.997 [0.99, 1.01] 0.546

During the follow-up period (1.1.1998 — 31.12.2019), 122 out of 874 females with F5_PERSOTH died.

Males

Parameter HR [95% CI] p-value
F5_PERSOTH 3.707 [2.77, 4.95] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 154 out of 864 males with F5_PERSOTH died.

Mortality risk

Mortality risk for people of age

years, who have F5_PERSOTH.

N-year risk Females Males
1 0.438% 0.701%
5 2.464% 4.344%
10 5.706% 9.585%
15 10.864% 17.3%
20 18.266% 27.732%

Relationships between endpoints

↥

Index endpoint: F5_PERSOTH – Other and unspecified disorders of adult personality and behaviour

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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