Other and unspecified neuropathies

G6_HERIPOTHUN

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G60.8, G60.9 Hospital discharge: ICD-9 — 356[8-9] Cause of death: ICD-10 — G60.8, G60.9 Cause of death: ICD-9 — 356[8-9] 2 out of 7 registries used, show all original rules.	152
4. Check minimum number of events None	152
5. Include endpoints None	152
6. Filter based on genotype QC (FinnGen only)	152

Control definitions (FinnGen only)

Control exclude: G6_POLYNEU

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	G6_HERIPOTHUN
CONTROL_EXCLUDE	G6_POLYNEU
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G60[8-9]
HD_ICD_9	356[8-9]
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G60[8-9]
COD_ICD_9	356[8-9]
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other and unspecified neuropathies based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1396	595	779
Only index persons	972	439	533
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	55.99	55.26	56.05
Only index persons	49.86	48.73	50.80

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	152	67	85
Unadjusted period prevalence (%)	0.03	0.02	0.04
Median age at first event (years)	52.59	47.10	56.92

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
138: Matched controls
1377

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G60.9

ICD-10 Finland

Hereditary and idiopathic neuropathy, unspecified

+∞

72.4

G60.8

ICD-10 Finland

Other hereditary and idiopathic neuropathies

+∞

58.6

G60.0

ICD-10 Finland

Hereditary motor and sensory neuropathy

+∞

47.7

G62.9

ICD-10 Finland

Polyneuropathy, unspecified

121.0

46.4

3569X

ICD-9 Finland

Hereditary and idiopathic peripheral neuropathy, Unspecified

+∞

24.7

G62.8

ICD-10 Finland

Other specified polyneuropathies

+∞

14.8

3568X

ICD-9 Finland

Hereditary and idiopathic peripheral neuropathy, Other specified idiopathic peripheral neuropathy

+∞

12.7

Z50.1

ICD-10 Finland

Other physical therapy

8.8

9.5

Z31.5

ICD-10 Finland

Genetic counselling

8.5

9.3

N03AE01

ATC

clonazepam; systemic

7.9

8.9

N03AX12

ATC

gabapentin; oral

4.1

8.8

114

R1250

NOMESCO Finland

Evaluation of functional capability

14.0

8.6

M60.8

ICD-10 Finland

Other myositis

84.4

7.5

TAB00

NOMESCO Finland

Lumbar puncture

10.2

7.5

A28

ICPC

Limited function/disability NOS

3.6

7.3

120

N03AX16

ATC

pregabalin; oral

3.2

7.0

168

M60.9

ICD-10 Finland

Myositis, unspecified

42.2

6.8

NHL68

NOMESCO Finland

Tenodesis, shortening or lengthening of tendon of foot

73.0

6.5

R4110

NOMESCO Finland

Physiotherapy

2.9

6.5

199

G63.2*E11.4

ICD-10 Finland

Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3037522) Nuclear Ab [Titer] in Serum

152

2.69

5.63

1.3

1.4

512.0

561.1

titre

—

(3031040) Bacteria [#/volume] in Urine by Automated count

106

788

2.14

4.44

5.5

4.2

—

124.4

—

(3002582) Erythrocytes [#/volume] in Urine

384

2.04

4.25

4.1

3.4

11.0

195.8

e6/l

0.58

298

(3004588) Protein electrophoresis panel - Serum or Plasma

2.79

4.19

2.4

2.1

—

(3000850) Epithelial cells [#/volume] in Urine

267

2.10

4.04

3.6

2.6

4.0

4.5

e6/l

0.21

233

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.13

3.87

2.3

2.1

—

(3030467) Casts [#/volume] in Urine by Automated count

353

1.98

3.84

4.0

3.3

0.2

0.6

e6/l

1.48

267

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

441

1.93

3.77

4.9

3.4

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

8.08

3.60

1.0

1.1

—

(3018095) Leukocytes [#/volume] in Urine

438

1.90

3.58

4.6

3.9

80.2

57.9

e6/l

0.16

315

(36304419) Bacteria [Presence] in Urine

338

1.93

3.48

4.1

3.1

—

(3026008) Bacteria identified in Urine by Culture

356

1.91

3.43

4.6

2.9

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.61

3.29

1.7

1.3

—

(3023410) Appearance of Cerebral spinal fluid

6.61

3.22

1.1

1.4

—

(1616796) Gas panel - Central venous blood

3.62

3.10

3.1

2.8

—

(1761482) Bacteria [#/volume] in Urine by Culture

3.50

2.96

5.8

6.4

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

2.87

0.0

1.4

—

(3012544) pH of Venous blood

113

2.22

2.79

5.0

5.2

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

8.56

2.77

1.0

5.2

23.8

32.2

umol/l

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

203

1.94

2.76

2.8

3.1

0.8

1.0

e6/l

0.21

114

(3022096) Basophils/100 leukocytes in Blood

563

1.70

2.64

6.3

5.6

0.5

0.7

1.70

517

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

583

1.69

2.61

5.8

6.7

1.2

mmol/l

0.18

494

(3037467) Urinalysis macro (dipstick) panel - Urine

102

821

1.74

2.58

5.6

4.2

—

(3016018) Differential panel - Cerebral spinal fluid

7.33

2.57

1.0

1.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

476

1.68

2.50

2.0

1.9

86.4

93.1

pmol/l

0.71

245

(3001604) Monocytes [#/volume] in Blood

619

1.66

2.44

6.5

5.4

0.6

e9/l

0.10

526

(3013115) Eosinophils [#/volume] in Blood

639

1.66

2.42

6.6

5.8

0.2

e9/l

1.30

562

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

3.78

2.40

1.4

1.5

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

3.78

2.40

1.6

1.3

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

3.78

2.40

1.4

1.5

—

(3006315) Basophils [#/volume] in Blood

621

1.65

2.39

6.6

5.4

0.0

e9/l

0.55

532

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

6.41

2.39

1.0

—

(3044290) Cell count panel - Cerebral spinal fluid

4.26

2.39

1.3

1.4

—

(3013707) Erythrocyte sedimentation rate by Westergren method

107

885

1.71

2.33

4.5

4.0

12.7

12.2

mm/h

0.13

798

(3023368) Bacteria identified in Blood by Culture

358

1.69

2.31

5.8

4.5

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.75

2.24

1.8

1.6

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

5.70

2.23

1.0

1.1

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

5.70

2.23

1.0

1.1

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.45

2.11

3.5

2.2

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

723

1.60

2.10

7.9

9.9

4.2

4.1

e9/l

0.02

623

(3021901) Oxygen saturation in Capillary blood

3.19

2.04

7.3

2.6

—

(3019309) Folate [Moles/volume] in Red Blood Cells

223

1.74

2.03

1.7

929.2

1183.2

nmol/l

0.70

171

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

369

1.62

2.02

3.2

802.5

1205.3

ng/l

0.72

306

(3019198) Lymphocytes [#/volume] in Blood

639

1.57

2.01

6.7

5.4

1.8

1.9

e9/l

0.88

562

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

3.86

1.95

1.3

1.6

—

(42870588) Differential panel, method unspecified - Blood

401

1.58

1.90

5.1

5.3

—

(3021589) Normoblasts [#/volume] in Blood

550

1.55

1.87

12.8

10.1

0.0

e9/l

0.52

446

(3018418) pH of Serum or Plasma

359

1.59

1.83

2.6

3.8

7.4

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

247

1.66

1.81

1.8

1.9

1.4

1.5

mg/l

0.15

193

(40760888) Immunoglobulin light chains.free panel - Serum

2.76

1.75

1.3

3.8

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

521

1.51

1.70

3.8

4.8

34.7

35.3

g/l

0.31

487

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.98

1.68

1.6

1.5

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

193

1.69

1.68

2.7

3.4

1.6

2.3

e6/l

0.25

106

(3042936) Bacteria identified in Isolate by Culture

185

1.70

1.67

2.1

1.9

—

(3009261) Glucose [Presence] in Urine by Test strip

589

1.50

1.67

5.7

3.7

0.0

estimate

0.00

113

(3012095) Magnesium [Moles/volume] in Serum or Plasma

194

1.68

1.65

3.8

3.4

0.8

mmol/l

0.74

180

(4062490)

3.65

1.63

1.0

1.1

—

(3000330) Specific gravity of Urine by Test strip

2.20

1.60

6.0

4.7

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

1.55

0.0

1.8

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.04

1.54

6.1

7.1

25.5

24.8

mmol/l

0.19

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

2.31

1.50

1.4

1.8

50.8

35.9

u/l

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

104

1.83

1.44

5.0

6.5

1.7

1.5

mmol/l

0.36

(3035350) Ketones [Presence] in Urine by Test strip

583

1.45

1.43

5.7

3.6

0.0

estimate

0.00

125

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

3.00

1.37

1.2

1.5

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

3.00

1.37

4.8

3.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

580

1.42

1.32

8.5

5.1

0.0

estimate

0.00

123

(3023323) Follitropin [Units/volume] in Serum or Plasma

2.43

1.31

2.9

1.3

16.4

19.8

iu/l

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

2.29

1.26

1.0

1.2

—

11.8

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

2.46

1.25

1.5

1.1

—

(1761868) Lipid panel - Serum or Plasma

423

0.66

1.21

2.6

3.0

—

(3027315) Oxygen [Partial pressure] in Blood

2.36

1.20

2.7

2.9

8.2

kpa

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.36

1.20

2.7

2.9

5.3

4.9

kpa

—

(3037756) Immunofixation for Serum or Plasma

2.36

1.20

1.2

1.4

—

(3019150) Specific gravity of Urine by Refractometry

263

1.48

1.19

6.5

3.7

1.0

kg/l

0.29

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

147

0.52

1.11

3.1

2.0

—

(3000991) Gas panel - Venous blood

106

1.68

1.08

7.2

8.1

—

(3025941) Bacteria identified in Stool by Culture

1.86

1.08

1.2

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.17

1.07

1.1

1.2

—

(40768804) Tissue Pathology biopsy report

467

0.70

1.06

2.3

2.1

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

2.02

1.06

1.3

3.2

—

4.0

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.69

1.05

3.4

2.2

286.7

363.1

nmol/l

0.94

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

134

0.50

1.04

2.1

1.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

141

1.57

1.01

2.2

1.5

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

118

1078

1.42

1.01

4.5

4.4

1.6

2.0

mu/l

3.64

111

968

(43055120) Cytomegalovirus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

2.21

0.99

1.2

7.3

—

854.0

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

2.21

0.99

1.2

1.7

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.21

0.99

1.2

1.6

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.99

0.98

1.4

1.6

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

120

0.48

0.98

1.2

1.5

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

136

1279

1.60

0.98

21.1

16.9

65.7

79.0

umol/l

8.98

136

1279

(3044640) Blood type and Crossmatch panel - Blood

385

1.36

0.94

2.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

461

1.34

0.93

6.7

3.8

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.19

0.92

1.2

1.6

—

(3000494) Fungus identified in Specimen by Culture

153

1.51

0.92

1.2

1.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

207

1.43

0.88

2.1

2.0

—

(40758558) Short blood count panel - Blood

327

1.35

0.83

7.4

6.9

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.91

0.82

1.0

1.1

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

140

1.49

0.82

6.7

8.0

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.80

0.0

1.4

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.80

0.0

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.80

0.0

1.4

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.80

0.0

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.80

0.0

1.4

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.80

0.0

1.4

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.79

0.0

1.5

—

(3002385) Erythrocyte distribution width [Ratio]

111

1020

1.33

0.79

21.3

17.6

13.7

13.8

0.35

111

1003

(36660697) Celiac disease serology panel - Serum

1.59

0.78

1.2

—

(3032080) INR in Blood by Coagulation assay

481

1.30

0.78

9.4

8.3

1.2

1.3

inr

0.69

154

(3011397) Hemoglobin [Presence] in Urine by Test strip

266

1.36

0.78

6.2

3.4

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.77

0.0

1.6

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

123

1150

1.36

0.75

4.1

4.6

6.2

6.0

mmol/l

0.42

113

1038

(3041096) Erythrocytes [Presence] in Urine by Automated

332

1.32

0.75

4.9

3.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

143

1.46

0.75

1.9

1.8

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

2.03

0.73

1.2

1.6

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

121

1131

1.34

0.72

16.7

13.8

93.1

80.9

ml/min/173m2

4.74

106

919

(3003396) Base excess in Arterial blood by calculation

136

1.45

0.71

8.6

6.9

2.6

1.4

mmol/l

0.24

108

(3021440) Promyelocytes/100 leukocytes in Blood

102

1.52

0.70

3.1

4.7

—

0.2

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

1.88

0.69

1.0

1.1

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.88

0.69

1.2

1.3

—

(3022313) Gas panel - Capillary blood

1.62

0.67

5.2

4.7

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

1.81

0.67

1.0

1.2

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

395

1.27

0.65

4.0

3.3

2.3

mmol/l

0.04

342

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

472

1.26

0.64

4.1

3.9

37.6

48.3

ng/l

0.33

338

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.59

0.64

1.8

1.7

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

256

1.32

0.64

1.6

1.8

525000428.5

419.6

pmol/l

0.48

217

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

293

1.30

0.64

2.4

—

(3033658) Prothrombin time (PT) actual/Normal

312

1.29

0.63

3.9

4.0

83.3

89.7

0.78

307

(40761535) Cells panel - Urine sediment

1.49

0.61

6.1

3.3

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.60

0.0

1.1

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.59

0.0

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.59

0.0

1.4

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.65

0.56

1.3

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.60

0.55

1.3

1.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.60

0.55

1.3

1.2

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

1.60

0.55

16.5

2.6

28.4

24.3

mmol/l

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.41

0.51

1.2

1.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

551

1.21

0.51

4.6

4.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

106

0.64

0.51

1.0

1.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

143

0.68

0.50

1.2

1.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

265

1.26

0.50

5.0

5.1

—

(3013512) EKG study

351

1.23

0.48

4.0

4.4

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

184

1.29

0.47

1.7

2.2

29.4

30.0

0.22

176

(3022621) pH of Urine by Test strip

1.48

0.45

4.2

2.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

867

1.19

0.43

3.8

3.7

14.8

14.7

pmol/l

0.01

778

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.63

0.43

1.2

1.3

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.63

0.43

1.4

—

(3025159) Blasts/100 leukocytes in Blood

1.39

0.43

3.5

5.0

—

0.0

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

141

1.31

0.42

2.0

1.8

—

(3019060) Gas panel - Arterial blood

1.42

0.42

9.3

4.1

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

1.53

0.41

2.0

1.8

—

0.0

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.41

0.0

1.2

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.41

0.0

1.2

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.41

0.0

1.7

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.41

0.0

1.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.41

0.0

1.2

—

(40768795) Lymph node Pathology biopsy report

0.00

0.39

0.0

1.2

—

(4010399)

0.65

0.36

1.4

1.3

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

125

1205

1.21

0.35

20.9

14.7

26.7

24.6

mg/l

0.32

114

971

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

231

1.21

0.32

4.3

3.3

1254.9

157.4

ng/l

0.43

176

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.29

0.32

2.5

2.3

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

1.32

0.31

2.8

3.3

80.4

64.1

ml/min/173m2

—

(3020779) Urea [Moles/volume] in Serum or Plasma

103

1.29

0.29

5.1

6.3

7.1

9.0

mmol/l

0.77

(4035726)

116

0.76

0.28

1.6

1.4

—

(3022217) INR in Platelet poor plasma by Coagulation assay

142

1.22

0.26

13.8

22.8

1.3

inr

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.20

0.25

1.2

1.3

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.36

0.24

1.4

1.2

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.33

0.23

1.0

1.3

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

384

1.13

0.23

4.6

21.5

21.0

0.08

191

(3002256) Pathology report gross observation

144

1.20

0.23

1.2

1.3

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.29

0.23

1.4

1.8

—

(3052851) Hemolysis interference index of Serum or Plasma

1.26

0.22

2.0

3.0

—

(3044889) 12 lead EKG panel

831

1.11

0.22

4.2

3.8

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.23

0.22

2.2

1.4

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.4

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

16.9

—

1939.2

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.4

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.4

—

(3016750) Collection duration of Urine

0.00

0.21

0.0

2.2

—

497.2

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.4

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.21

0.0

2.3

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.21

0.0

1.0

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

7.7

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.21

0.0

1.1

—

(3011648) Oxygen content in Venous blood

0.00

0.21

0.0

4.3

—

11.4

—

(40768806) Pleura Pathology biopsy report

0.00

0.21

0.0

2.3

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.21

0.0

1.4

—

227.7

—

(40768441) Liver Pathology biopsy report

0.00

0.21

0.0

1.6

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.21

0.0

1.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.21

0.0

1.2

—

(3019225) pH of Specimen

108

1.22

0.21

3.1

4.4

—

(3020891) Body temperature

1.26

0.20

14.5

5.3

—

(4146454)

0.00

0.20

0.0

2.1

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.20

0.0

2.0

—

33.5

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.20

0.0

1.1

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.20

0.0

1.3

—

(3049717) Cytology report of Urine Cyto stain

1.23

0.20

3.7

2.8

—

(3009508) Creatinine [Moles/volume] in Urine

382

0.89

0.20

3.2

7.8

mmol/l

0.01

307

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.18

0.19

2.8

2.6

—

(3012516) Albumin [Mass/volume] in Urine

339

0.89

0.18

3.2

42.0

77.8

mg/l

0.60

222

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

109

1119

0.91

0.17

4.3

4.0

1.4

1.3

mmol/l

0.49

1019

(46235355) HIV 1 and 2 tests - Meaningful Use set

223

0.88

0.15

1.3

1.7

—

(3003694) ABO and Rh group [Type] in Blood

325

0.90

0.15

1.6

1.4

—

(21494755) Public health laboratory ask at order entry panel

109

0.81

0.13

1.6

1.5

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

121

1188

1.09

0.12

4.8

4.9

2.7

mmol/l

0.10

110

1085

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

126

0.86

0.12

1.4

1.6

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

487

1.07

0.11

4.8

5.2

1.9

2.7

ug/l

0.65

434

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

202

1.10

0.11

1.5

1.3

23.2

41.0

iu/ml

—

(3007164) IgA [Mass/volume] in Serum or Plasma

251

1.09

0.11

1.5

1.4

2.2

2.7

g/l

1.09

150

(40761511) CBC panel - Blood by Automated count

124

1259

0.92

0.11

16.3

13.4

—

(3029937) Albumin [Presence] in Urine by Test strip

330

1.08

0.10

6.4

3.7

0.0

estimate

0.00

115

(3002179) Metamyelocytes/100 leukocytes in Blood

1.16

0.10

3.7

4.6

—

0.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

124

0.88

0.09

4.3

3.5

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.09

0.09

1.8

1.6

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.04

0.08

10.0

7.9

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

522

1.05

0.08

2.5

2.7

118.2

127.2

ug/l

0.18

472

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

0.83

0.08

1.0

1.2

—

139.2

iu/ml

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.85

0.07

1.4

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

114

1155

0.95

0.06

4.4

1.4

mmol/l

1.19

105

1053

(40768797) Stomach Pathology biopsy report

158

1.09

0.06

1.1

1.2

—

(3009542) Hematocrit [Volume Fraction] of Blood

110

1085

1.05

0.06

20.3

15.0

37.0

40.1

1.41

788

(3000492) Spirometry study

110

0.90

0.05

1.4

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

179

1.07

0.05

1.7

2.4

25.1

23.6

0.05

155

(3022145) Colonoscopy Study observation

130

1.08

0.05

1.1

1.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

219

1.06

0.04

1.9

1.5

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

150

0.93

0.04

4.1

4.3

31.3

32.2

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

117

1161

1.03

0.02

4.6

4.4

4.5

4.6

mmol/l

0.04

107

1068

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

769

0.98

0.02

2.8

3.0

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

282

1.04

0.02

3.3

3.1

0.6

0.7

ug/l

0.41

184

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

111

1103

1.02

0.01

5.9

39.8

40.3

mmol/mol

0.18

102

1029

(3022948) Iron [Moles/volume] in Serum or Plasma

204

1.03

0.00

1.9

2.3

10.1

13.7

umol/l

1.22

185

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

309

1.00

0.00

1.7

1.6

1.4

1.3

mmol/l

0.26

250

(40761536) Microorganisms panel - Urine sediment

107

1.03

0.00

3.5

3.7

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

147

1.02

0.00

1.4

1.3

—

(3020682) Albumin/Creatinine [Ratio] in Urine

363

0.99

0.00

3.5

4.0

4.9

9.9

mg/mmol

0.96

233

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

188

1.01

0.00

1.4

1.3

1.0

9.8

u/ml

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

6.2

—

45.7

—

(3005011) Chlamydia sp Ab [Titer] in Serum

0.00

0.0

1.4

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3047189) Immunofixation for 24 hour Urine

0.00

0.0

1.2

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.2

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

0.0

1.7

—

(3012565) Volume of 24 hour Urine

0.00

0.0

2.5

—

2324.2

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.0

—

6.1

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

1.1

—

2.9

—

(3011436) Histone Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

0.00

0.0

1.8

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.4

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

38.8

—

(40758292) HTLV I+II Ab panel - Serum

0.00

0.0

1.7

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.2

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

6.1

—

226.6

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

170

1.00

0.00

1.2

1.6

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

6.9

—

102.4

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.1

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

0.0

2.4

—

1.3

—

(3018658) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.89

0.00

2.0

1.9

—

(4281824)

0.00

0.0

1.0

—

(3008898) HLA-B27 [Presence]

0.98

0.00

1.2

1.1

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

2.8

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.6

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

1.9

—

62.1

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.6

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.6

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

1.0

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.0

—

(44806420)

0.00

0.0

1.6

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(1002224) Polysomnography panel

1.00

0.00

1.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_HERIPOTHUN and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_HERIPOTHUN	1.949 [1.41, 2.69]	< 0.001
Birth year	0.996 [0.99, 1.0]	0.339

During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 327 females with G6_HERIPOTHUN died.

Males

Parameter	HR [95% CI]	p-value
G6_HERIPOTHUN	1.706 [1.3, 2.23]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.051

During the follow-up period (1.1.1998 — 31.12.2019), 92 out of 395 males with G6_HERIPOTHUN died.

Mortality risk

Mortality risk for people of age

years, who have G6_HERIPOTHUN.

N-year risk	Females	Males
1	0.17%	0.291%
5	1.14%	2.114%
10	2.679%	5.458%
15	5.451%	10.265%
20	9.551%	16.625%

Relationships between endpoints

↥

Index endpoint: G6_HERIPOTHUN – Other and unspecified neuropathies

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other and unspecified neuropathies

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints