No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
152 |
4. Check minimum number of eventsNone |
152 |
5. Include endpointsNone |
152 |
6. Filter based on genotype QC (FinnGen only) |
152 |
Control definitions (FinnGen only)
- Control exclude
- G6_POLYNEU
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified neuropathies
based on the number of shared cases.
Similar with more cases:
- Polyneuropathies and other disorders of the peripheral nervous system
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1396 | 595 | 779 |
| Only index persons | 972 | 439 | 533 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 55.99 | 55.26 | 56.05 |
| Only index persons | 49.86 | 48.73 | 50.80 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 152 | 67 | 85 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.04 |
| Median age at first event (years) | 52.59 | 47.10 | 56.92 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 138
- Matched controls
- 1377
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G60.9
ICD-10 Finland
Hereditary and idiopathic neuropathy, unspecified
+∞
72.4
63
*
G60.8
ICD-10 Finland
Other hereditary and idiopathic neuropathies
+∞
58.6
52
*
G60.0
ICD-10 Finland
Hereditary motor and sensory neuropathy
+∞
47.7
43
*
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
121.0
46.4
48
6
3569X
ICD-9 Finland
Hereditary and idiopathic peripheral neuropathy, Unspecified
+∞
24.7
23
*
G62.8
ICD-10 Finland
Other specified polyneuropathies
+∞
14.8
14
*
3568X
ICD-9 Finland
Hereditary and idiopathic peripheral neuropathy, Other specified idiopathic peripheral neuropathy
+∞
12.7
12
*
Z50.1
ICD-10 Finland
Other physical therapy
8.8
9.5
20
26
Z31.5
ICD-10 Finland
Genetic counselling
8.5
9.3
20
27
N03AE01
ATC
clonazepam; systemic
7.9
8.9
20
29
N03AX12
ATC
gabapentin; oral
4.1
8.8
37
114
R1250
NOMESCO Finland
Evaluation of functional capability
14.0
8.6
14
11
M60.8
ICD-10 Finland
Other myositis
84.4
7.5
8
*
TAB00
NOMESCO Finland
Lumbar puncture
10.2
7.5
14
15
A28
ICPC
Limited function/disability NOS
3.6
7.3
35
120
N03AX16
ATC
pregabalin; oral
3.2
7.0
42
168
M60.9
ICD-10 Finland
Myositis, unspecified
42.2
6.8
8
*
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
73.0
6.5
7
*
R4110
NOMESCO Finland
Physiotherapy
2.9
6.5
45
199
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3037522) Nuclear Ab [Titer] in Serum
35
152
2.69
5.63
1.3
1.4
titre
512.0
561.1
—
10
35
(3031040) Bacteria [#/volume] in Urine by Automated count
106
788
2.14
4.44
5.5
4.2
—
124.4
—
0
14
(3002582) Erythrocytes [#/volume] in Urine
62
384
2.04
4.25
4.1
3.4
e6/l
11.0
195.8
0.58
51
298
(3004588) Protein electrophoresis panel - Serum or Plasma
22
87
2.79
4.19
2.4
2.1
—
—
—
0
0
(3000850) Epithelial cells [#/volume] in Urine
47
267
2.10
4.04
3.6
2.6
e6/l
4.0
4.5
0.21
39
233
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
16
55
3.13
3.87
2.3
2.1
—
—
—
0
0
(3030467) Casts [#/volume] in Urine by Automated count
57
353
1.98
3.84
4.0
3.3
e6/l
0.2
0.6
1.48
48
267
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
67
441
1.93
3.77
4.9
3.4
—
—
—
0
0
(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay
7
9
8.08
3.60
1.0
1.1
—
—
—
0
0
(3018095) Leukocytes [#/volume] in Urine
66
438
1.90
3.58
4.6
3.9
e6/l
80.2
57.9
0.16
55
315
(36304419) Bacteria [Presence] in Urine
54
338
1.93
3.48
4.1
3.1
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
56
356
1.91
3.43
4.6
2.9
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
19
79
2.61
3.29
1.7
1.3
—
—
—
0
0
(3023410) Appearance of Cerebral spinal fluid
7
11
6.61
3.22
1.1
1.4
—
—
—
0
0
(1616796) Gas panel - Central venous blood
10
29
3.62
3.10
3.1
2.8
—
—
—
0
0
(1761482) Bacteria [#/volume] in Urine by Culture
10
30
3.50
2.96
5.8
6.4
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
72
0.00
2.87
0.0
1.4
—
—
—
0
0
(3012544) pH of Venous blood
23
113
2.22
2.79
5.0
5.2
—
—
—
0
0
(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma
5
6
8.56
2.77
1.0
5.2
umol/l
23.8
32.2
—
5
6
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
35
203
1.94
2.76
2.8
3.1
e6/l
0.8
1.0
0.21
26
114
(3022096) Basophils/100 leukocytes in Blood
76
563
1.70
2.64
6.3
5.6
%
0.5
0.7
1.70
71
517
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
78
583
1.69
2.61
5.8
6.7
mmol/l
1.2
1.2
0.18
70
494
(3037467) Urinalysis macro (dipstick) panel - Urine
102
821
1.74
2.58
5.6
4.2
—
—
—
0
0
(3016018) Differential panel - Cerebral spinal fluid
5
7
7.33
2.57
1.0
1.3
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
66
476
1.68
2.50
2.0
1.9
pmol/l
86.4
93.1
0.71
40
245
(3001604) Monocytes [#/volume] in Blood
81
619
1.66
2.44
6.5
5.4
e9/l
0.6
0.6
0.10
74
526
(3013115) Eosinophils [#/volume] in Blood
83
639
1.66
2.42
6.6
5.8
e9/l
0.2
0.2
1.30
74
562
(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay
8
22
3.78
2.40
1.4
1.5
—
—
—
0
0
(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain
8
22
3.78
2.40
1.6
1.3
—
—
—
0
0
(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay
8
22
3.78
2.40
1.4
1.5
—
—
—
0
0
(3006315) Basophils [#/volume] in Blood
81
621
1.65
2.39
6.6
5.4
e9/l
0.0
0.0
0.55
74
532
(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid
5
8
6.41
2.39
1.0
1.0
—
—
—
0
0
(3044290) Cell count panel - Cerebral spinal fluid
7
17
4.26
2.39
1.3
1.4
—
—
—
0
0
(3013707) Erythrocyte sedimentation rate by Westergren method
107
885
1.71
2.33
4.5
4.0
mm/h
12.7
12.2
0.13
99
798
(3023368) Bacteria identified in Blood by Culture
52
358
1.69
2.31
5.8
4.5
—
—
—
0
0
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
11
42
2.75
2.24
1.8
1.6
—
—
—
0
0
(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid
5
9
5.70
2.23
1.0
1.1
—
—
—
0
0
(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid
5
9
5.70
2.23
1.0
1.1
—
—
—
0
0
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
13
56
2.45
2.11
3.5
2.2
—
—
—
0
0
(3013650) Neutrophils [#/volume] in Blood by Automated count
90
723
1.60
2.10
7.9
9.9
e9/l
4.2
4.1
0.02
79
623
(3021901) Oxygen saturation in Capillary blood
8
26
3.19
2.04
7.3
2.6
—
—
—
0
0
(3019309) Folate [Moles/volume] in Red Blood Cells
35
223
1.74
2.03
1.7
1.7
nmol/l
929.2
1183.2
0.70
26
171
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
52
369
1.62
2.02
3.2
3.2
ng/l
802.5
1205.3
0.72
42
306
(3019198) Lymphocytes [#/volume] in Blood
81
639
1.57
2.01
6.7
5.4
e9/l
1.8
1.9
0.88
74
562
(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma
6
16
3.86
1.95
1.3
1.6
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
55
401
1.58
1.90
5.1
5.3
—
—
—
0
0
(3021589) Normoblasts [#/volume] in Blood
71
550
1.55
1.87
12.8
10.1
e9/l
0.0
0.0
0.52
63
446
(3018418) pH of Serum or Plasma
50
359
1.59
1.83
2.6
3.8
ph
7.4
7.4
—
7
67
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
37
247
1.66
1.81
1.8
1.9
mg/l
1.4
1.5
0.15
29
193
(40760888) Immunoglobulin light chains.free panel - Serum
8
30
2.76
1.75
1.3
3.8
—
—
—
0
0
(3024561) Albumin [Mass/volume] in Serum or Plasma
67
521
1.51
1.70
3.8
4.8
g/l
34.7
35.3
0.31
62
487
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
17
91
1.98
1.68
1.6
1.5
—
—
—
0
0
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
30
193
1.69
1.68
2.7
3.4
e6/l
1.6
2.3
0.25
22
106
(3042936) Bacteria identified in Isolate by Culture
29
185
1.70
1.67
2.1
1.9
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
74
589
1.50
1.67
5.7
3.7
estimate
0.0
0.0
0.00
14
113
(3012095) Magnesium [Moles/volume] in Serum or Plasma
30
194
1.68
1.65
3.8
3.4
mmol/l
0.8
0.8
0.74
30
180
(4062490)
5
14
3.65
1.63
1.0
1.1
—
—
—
0
0
(3000330) Specific gravity of Urine by Test strip
12
57
2.20
1.60
6.0
4.7
—
—
—
0
0
(3001019) Free T4 and TSH panel - Serum or Plasma
0
42
0.00
1.55
0.0
1.8
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
14
72
2.04
1.54
6.1
7.1
mmol/l
25.5
24.8
0.19
14
72
(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma
10
45
2.31
1.50
1.4
1.8
u/l
50.8
35.9
—
10
39
(3014111) Lactate [Moles/volume] in Serum or Plasma
18
104
1.83
1.44
5.0
6.5
mmol/l
1.7
1.5
0.36
18
96
(3035350) Ketones [Presence] in Urine by Test strip
72
583
1.45
1.43
5.7
3.6
estimate
0.0
0.0
0.00
14
125
(3009340) Metanephrine [Moles/volume] in Serum or Plasma
5
17
3.00
1.37
1.2
1.5
—
—
—
0
0
(3033705) Calcium.ionized [Moles/volume] in Venous blood
5
17
3.00
1.37
4.8
3.4
—
—
—
0
0
(3021601) Nitrite [Presence] in Urine by Test strip
71
580
1.42
1.32
8.5
5.1
estimate
0.0
0.0
0.00
14
123
(3023323) Follitropin [Units/volume] in Serum or Plasma
8
34
2.43
1.31
2.9
1.3
iu/l
16.4
19.8
—
8
29
(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum
8
36
2.29
1.26
1.0
1.2
—
11.8
—
0
8
(3050238) Crystals [Presence] in Synovial fluid by Light microscopy
6
25
2.46
1.25
1.5
1.1
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
31
423
0.66
1.21
2.6
3.0
—
—
—
0
0
(3027315) Oxygen [Partial pressure] in Blood
6
26
2.36
1.20
2.7
2.9
kpa
8.2
8.2
—
6
26
(3013290) Carbon dioxide [Partial pressure] in Blood
6
26
2.36
1.20
2.7
2.9
kpa
5.3
4.9
—
6
26
(3037756) Immunofixation for Serum or Plasma
6
26
2.36
1.20
1.2
1.4
—
—
—
0
0
(3019150) Specific gravity of Urine by Refractometry
36
263
1.48
1.19
6.5
3.7
kg/l
1.0
1.0
0.29
14
36
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
8
147
0.52
1.11
3.1
2.0
—
—
—
0
0
(3000991) Gas panel - Venous blood
17
106
1.68
1.08
7.2
8.1
—
—
—
0
0
(3025941) Bacteria identified in Stool by Culture
12
67
1.86
1.08
1.2
1.2
—
—
—
0
0
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
7
33
2.17
1.07
1.1
1.2
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
36
467
0.70
1.06
2.3
2.1
—
—
—
0
0
(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum
9
46
2.02
1.06
1.3
3.2
—
4.0
—
0
5
(3036481) Cortisol [Moles/volume] in Serum or Plasma
16
99
1.69
1.05
3.4
2.2
nmol/l
286.7
363.1
0.94
16
89
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
7
134
0.50
1.04
2.1
1.8
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
21
141
1.57
1.01
2.2
1.5
—
—
—
0
0
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
118
1078
1.42
1.01
4.5
4.4
mu/l
1.6
2.0
3.64
111
968
(43055120) Cytomegalovirus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection
5
23
2.21
0.99
1.2
7.3
—
854.0
—
0
6
(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection
5
23
2.21
0.99
1.2
1.7
—
—
—
0
0
(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection
5
23
2.21
0.99
1.2
1.6
—
—
—
0
0
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
7
36
1.99
0.98
1.4
1.6
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
6
120
0.48
0.98
1.2
1.5
—
—
—
0
0
(3020564) Creatinine [Moles/volume] in Serum or Plasma
136
1279
1.60
0.98
21.1
16.9
umol/l
65.7
79.0
8.98
136
1279
(3044640) Blood type and Crossmatch panel - Blood
48
385
1.36
0.94
2.5
2.5
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
56
461
1.34
0.93
6.7
3.8
—
—
—
0
0
(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection
6
28
2.19
0.92
1.2
1.6
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
22
153
1.51
0.92
1.2
1.4
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
28
207
1.43
0.88
2.1
2.0
—
—
—
0
0
(40758558) Short blood count panel - Blood
41
327
1.35
0.83
7.4
6.9
—
—
—
0
0
(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay
6
32
1.91
0.82
1.0
1.1
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
20
140
1.49
0.82
6.7
8.0
—
—
—
0
0
(3039443) Prostate specific Ag panel - Serum or Plasma
0
24
0.00
0.80
0.0
1.4
—
—
—
0
0
(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight
0
24
0.00
0.80
0.0
1.4
—
—
—
0
0
(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma
0
24
0.00
0.80
0.0
1.4
—
—
—
0
0
(3043238) Trisomy 21 risk [Likelihood] in Fetus
0
24
0.00
0.80
0.0
1.5
—
—
—
0
0
(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age
0
24
0.00
0.80
0.0
1.4
—
—
—
0
0
(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma
0
24
0.00
0.80
0.0
1.4
—
—
—
0
0
(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay
0
26
0.00
0.79
0.0
1.5
—
—
—
0
0
(3002385) Erythrocyte distribution width [Ratio]
111
1020
1.33
0.79
21.3
17.6
%
13.7
13.8
0.35
111
1003
(36660697) Celiac disease serology panel - Serum
14
91
1.59
0.78
1.2
1.2
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
57
481
1.30
0.78
9.4
8.3
inr
1.2
1.3
0.69
17
154
(3011397) Hemoglobin [Presence] in Urine by Test strip
34
266
1.36
0.78
6.2
3.4
—
—
—
0
0
(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma
0
28
0.00
0.77
0.0
1.6
—
—
—
0
0
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
123
1150
1.36
0.75
4.1
4.6
mmol/l
6.2
6.0
0.42
113
1038
(3041096) Erythrocytes [Presence] in Urine by Automated
41
332
1.32
0.75
4.9
3.5
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
20
143
1.46
0.75
1.9
1.8
—
—
—
0
0
(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection
5
25
2.03
0.73
1.2
1.6
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
121
1131
1.34
0.72
16.7
13.8
ml/min/173m2
93.1
80.9
4.74
106
919
(3003396) Base excess in Arterial blood by calculation
19
136
1.45
0.71
8.6
6.9
mmol/l
2.6
1.4
0.24
13
108
(3021440) Promyelocytes/100 leukocytes in Blood
15
102
1.52
0.70
3.1
4.7
—
0.2
—
0
34
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
5
27
1.88
0.69
1.0
1.1
—
—
—
0
0
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
5
27
1.88
0.69
1.2
1.3
—
—
—
0
0
(3022313) Gas panel - Capillary blood
11
70
1.62
0.67
5.2
4.7
—
—
—
0
0
(3043109) Cytology report of Tissue fine needle aspirate Cyto stain
5
28
1.81
0.67
1.0
1.2
—
—
—
0
0
(3015377) Calcium [Moles/volume] in Serum or Plasma
47
395
1.27
0.65
4.0
3.3
mmol/l
2.3
2.3
0.04
39
342
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
55
472
1.26
0.64
4.1
3.9
ng/l
37.6
48.3
0.33
41
338
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
11
71
1.59
0.64
1.8
1.7
—
—
—
0
0
(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma
32
256
1.32
0.64
1.6
1.8
pmol/l
525000428.5
419.6
0.48
24
217
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
36
293
1.30
0.64
2.4
2.4
—
—
—
0
0
(3033658) Prothrombin time (PT) actual/Normal
38
312
1.29
0.63
3.9
4.0
%
83.3
89.7
0.78
38
307
(40761535) Cells panel - Urine sediment
14
97
1.49
0.61
6.1
3.3
—
—
—
0
0
(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
22
0.00
0.60
0.0
1.1
—
—
—
0
0
(3005033) Fetal Nuchal fold Thickness US
0
23
0.00
0.59
0.0
1.4
—
—
—
0
0
(3047352) Trisomy 18 risk [Likelihood] in Fetus
0
23
0.00
0.59
0.0
1.4
—
—
—
0
0
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
6
37
1.65
0.56
1.3
1.2
—
—
—
0
0
(3014765) Yersinia sp identified in Stool by Organism specific culture
6
38
1.60
0.55
1.3
1.2
—
—
—
0
0
(42529406) Shigella sp [Presence] in Stool by Culture
6
38
1.60
0.55
1.3
1.2
—
—
—
0
0
(3015235) Bicarbonate [Moles/volume] in Capillary blood
6
38
1.60
0.55
16.5
2.6
mmol/l
28.4
24.3
—
6
32
(3013139) Helicobacter pylori Ag [Presence] in Stool
9
65
1.41
0.51
1.2
1.1
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
62
551
1.21
0.51
4.6
4.2
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
7
106
0.64
0.51
1.0
1.5
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
10
143
0.68
0.50
1.2
1.5
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
32
265
1.26
0.50
5.0
5.1
—
—
—
0
0
(3013512) EKG study
41
351
1.23
0.48
4.0
4.4
—
—
—
0
0
(3018677) aPTT in Platelet poor plasma by Coagulation assay
23
184
1.29
0.47
1.7
2.2
s
29.4
30.0
0.22
23
176
(3022621) pH of Urine by Test strip
10
69
1.48
0.45
4.2
2.2
—
—
—
0
0
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
93
867
1.19
0.43
3.8
3.7
pmol/l
14.8
14.7
0.01
86
778
(3024891) Influenza virus A+B Ag [Presence] in Specimen
5
31
1.63
0.43
1.2
1.3
—
—
—
0
0
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
5
31
1.63
0.43
1.4
1.4
—
—
—
0
0
(3025159) Blasts/100 leukocytes in Blood
13
96
1.39
0.43
3.5
5.0
—
0.0
—
0
30
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
18
141
1.31
0.42
2.0
1.8
—
—
—
0
0
(3019060) Gas panel - Arterial blood
11
79
1.42
0.42
9.3
4.1
—
—
—
0
0
(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood
5
33
1.53
0.41
2.0
1.8
—
0.0
—
0
9
(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
(3047007) Chlamydophila sp Ab [Presence] in Serum
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
(3025130) Human papilloma virus identified in Specimen
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
(3003740) Influenza virus B Ag [Presence] in Specimen
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
(3002523) Influenza virus A Ag [Presence] in Specimen
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
(40768795) Lymph node Pathology biopsy report
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
(4010399)
5
76
0.65
0.36
1.4
1.3
—
—
—
0
0
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
125
1205
1.21
0.35
20.9
14.7
mg/l
26.7
24.6
0.32
114
971
(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma
27
231
1.21
0.32
4.3
3.3
ng/l
1254.9
157.4
0.43
18
176
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
6
47
1.29
0.32
2.5
2.3
—
—
—
0
0
(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)
12
93
1.32
0.31
2.8
3.3
ml/min/173m2
80.4
64.1
—
7
39
(3020779) Urea [Moles/volume] in Serum or Plasma
13
103
1.29
0.29
5.1
6.3
mmol/l
7.1
9.0
0.77
13
97
(4035726)
9
116
0.76
0.28
1.6
1.4
—
—
—
0
0
(3022217) INR in Platelet poor plasma by Coagulation assay
17
142
1.22
0.26
13.8
22.8
inr
1.3
1.3
—
5
18
(3004716) Salmonella sp identified in Stool by Organism specific culture
9
76
1.20
0.25
1.2
1.3
—
—
—
0
0
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
5
37
1.36
0.24
1.4
1.2
—
—
—
0
0
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
5
38
1.33
0.23
1.0
1.3
—
—
—
0
0
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
42
384
1.13
0.23
4.6
4.6
%
21.5
21.0
0.08
21
191
(3002256) Pathology report gross observation
17
144
1.20
0.23
1.2
1.3
—
—
—
0
0
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
5
39
1.29
0.23
1.4
1.8
—
—
—
0
0
(3052851) Hemolysis interference index of Serum or Plasma
5
40
1.26
0.22
2.0
3.0
—
—
—
0
0
(3044889) 12 lead EKG panel
87
831
1.11
0.22
4.2
3.8
—
—
—
0
0
(3003327) Ova and parasites identified in Stool by Light microscopy
5
41
1.23
0.22
2.2
1.4
—
—
—
0
0
(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection
0
11
0.00
0.21
0.0
2.4
—
—
—
0
0
(3000081) cloZAPine [Moles/volume] in Serum or Plasma
0
11
0.00
0.21
0.0
16.9
—
1939.2
—
0
11
(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection
0
11
0.00
0.21
0.0
2.4
—
—
—
0
0
(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection
0
11
0.00
0.21
0.0
2.4
—
—
—
0
0
(3016750) Collection duration of Urine
0
11
0.00
0.21
0.0
2.2
—
497.2
—
0
6
(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection
0
11
0.00
0.21
0.0
2.4
—
—
—
0
0
(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
(3011363) Streptococcus pneumoniae Ag [Presence] in Urine
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
(3019420) Tryptase [Mass/volume] in Serum or Plasma
0
12
0.00
0.21
0.0
1.4
—
7.7
—
0
12
(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
(3011648) Oxygen content in Venous blood
0
12
0.00
0.21
0.0
4.3
—
11.4
—
0
12
(40768806) Pleura Pathology biopsy report
0
12
0.00
0.21
0.0
2.3
—
—
—
0
0
(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction
0
12
0.00
0.21
0.0
1.4
—
227.7
—
0
12
(40768441) Liver Pathology biopsy report
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
(1617658) Protocol used for examination of sentinel lymph nodes
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
(3019225) pH of Specimen
13
108
1.22
0.21
3.1
4.4
—
—
—
0
0
(3020891) Body temperature
6
48
1.26
0.20
14.5
5.3
—
—
—
0
0
(4146454)
0
14
0.00
0.20
0.0
2.1
—
—
—
0
0
(3029080) Hemoglobin [Entitic mass] in Reticulocytes
0
14
0.00
0.20
0.0
2.0
—
33.5
—
0
14
(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
(3045424) Erythrocytes [Presence] in Urine
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
(3049717) Cytology report of Urine Cyto stain
6
49
1.23
0.20
3.7
2.8
—
—
—
0
0
(3009508) Creatinine [Moles/volume] in Urine
35
382
0.89
0.20
3.2
3.2
mmol/l
7.8
7.8
0.01
30
307
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
6
51
1.18
0.19
2.8
2.6
—
—
—
0
0
(3012516) Albumin [Mass/volume] in Urine
31
339
0.89
0.18
3.2
3.2
mg/l
42.0
77.8
0.60
21
222
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
109
1119
0.91
0.17
4.3
4.0
mmol/l
1.4
1.3
0.49
98
1019
(46235355) HIV 1 and 2 tests - Meaningful Use set
20
223
0.88
0.15
1.3
1.7
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
30
325
0.90
0.15
1.6
1.4
—
—
—
0
0
(21494755) Public health laboratory ask at order entry panel
9
109
0.81
0.13
1.6
1.5
—
—
—
0
0
(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma
121
1188
1.09
0.12
4.8
4.9
mmol/l
2.7
2.7
0.10
110
1085
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
11
126
0.86
0.12
1.4
1.6
—
—
—
0
0
(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma
51
487
1.07
0.11
4.8
5.2
ug/l
1.9
2.7
0.65
43
434
(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma
22
202
1.10
0.11
1.5
1.3
iu/ml
23.2
41.0
—
9
67
(3007164) IgA [Mass/volume] in Serum or Plasma
27
251
1.09
0.11
1.5
1.4
g/l
2.2
2.7
1.09
16
150
(40761511) CBC panel - Blood by Automated count
124
1259
0.92
0.11
16.3
13.4
—
—
—
0
0
(3029937) Albumin [Presence] in Urine by Test strip
35
330
1.08
0.10
6.4
3.7
estimate
0.0
0.0
0.00
13
115
(3002179) Metamyelocytes/100 leukocytes in Blood
11
96
1.16
0.10
3.7
4.6
—
0.3
—
0
24
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
11
124
0.88
0.09
4.3
3.5
—
—
—
0
0
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
6
55
1.09
0.09
1.8
1.6
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
6
58
1.04
0.08
10.0
7.9
—
—
—
0
0
(3001122) Ferritin [Mass/volume] in Serum or Plasma
54
522
1.05
0.08
2.5
2.7
ug/l
118.2
127.2
0.18
48
472
(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma
6
72
0.83
0.08
1.0
1.2
iu/ml
—
139.2
—
0
23
(3021879) Hepatitis B virus core Ab [Presence] in Serum
8
93
0.85
0.07
1.4
1.4
—
—
—
0
0
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
114
1155
0.95
0.06
4.4
4.4
mmol/l
1.4
1.4
1.19
105
1053
(40768797) Stomach Pathology biopsy report
17
158
1.09
0.06
1.1
1.2
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
110
1085
1.05
0.06
20.3
15.0
%
37.0
40.1
1.41
74
788
(3000492) Spirometry study
10
110
0.90
0.05
1.4
1.4
—
—
—
0
0
(40763571) Iron/Transferrin [Ratio] in Serum or Plasma
19
179
1.07
0.05
1.7
2.4
%
25.1
23.6
0.05
12
155
(3022145) Colonoscopy Study observation
14
130
1.08
0.05
1.1
1.3
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
23
219
1.06
0.04
1.9
1.5
—
—
—
0
0
(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma
14
150
0.93
0.04
4.1
4.3
%
31.3
32.2
—
7
96
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
117
1161
1.03
0.02
4.6
4.4
mmol/l
4.5
4.6
0.04
107
1068
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
76
769
0.98
0.02
2.8
3.0
—
—
—
0
0
(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma
29
282
1.04
0.02
3.3
3.1
ug/l
0.6
0.7
0.41
23
184
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
111
1103
1.02
0.01
5.9
5.9
mmol/mol
39.8
40.3
0.18
102
1029
(3022948) Iron [Moles/volume] in Serum or Plasma
21
204
1.03
0.00
1.9
2.3
umol/l
10.1
13.7
1.22
16
185
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
31
309
1.00
0.00
1.7
1.6
mmol/l
1.4
1.3
0.26
26
250
(40761536) Microorganisms panel - Urine sediment
11
107
1.03
0.00
3.5
3.7
—
—
—
0
0
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
15
147
1.02
0.00
1.4
1.3
—
—
—
0
0
(3020682) Albumin/Creatinine [Ratio] in Urine
36
363
0.99
0.00
3.5
4.0
mg/mmol
4.9
9.9
0.96
26
233
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
19
188
1.01
0.00
1.4
1.3
u/ml
1.0
9.8
—
6
70
(3013727) Leukocytes other/100 leukocytes in Blood
0
6
0.00
0.00
0.0
6.2
—
45.7
—
0
6
(3005011) Chlamydia sp Ab [Titer] in Serum
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3037692) Legionella sp identified in Specimen by Organism specific culture
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3047189) Immunofixation for 24 hour Urine
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood
0
6
0.00
0.00
0.0
4.2
—
—
—
0
0
(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3008536) Aspergillus sp Ab [Presence] in Serum
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3012565) Volume of 24 hour Urine
0
6
0.00
0.00
0.0
2.5
—
2324.2
—
0
6
(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline
0
8
0.00
0.00
0.0
1.0
—
6.1
—
0
8
(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.1
—
2.9
—
0
8
(3011436) Histone Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(40765096) Chromosome analysis panel by Banding
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3005082) Progesterone [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.0
—
38.8
—
0
6
(40758292) HTLV I+II Ab panel - Serum
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood
0
6
0.00
0.00
0.0
4.2
—
—
—
0
0
(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
6.1
—
226.6
—
0
7
(3035933) Granulocytes/100 leukocytes in Blood
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
17
170
1.00
0.00
1.2
1.6
—
—
—
0
0
(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay
0
7
0.00
0.00
0.0
6.9
—
102.4
—
0
7
(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(3023709) Somatotropin [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
2.4
—
1.3
—
0
5
(3018658) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
6
67
0.89
0.00
2.0
1.9
—
—
—
0
0
(4281824)
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3008898) HLA-B27 [Presence]
5
51
0.98
0.00
1.2
1.1
—
—
—
0
0
(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.9
—
62.1
—
0
7
(3025018) Bordetella pertussis Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
(3037556) Urate [Mass/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection
0
9
0.00
0.00
0.0
2.4
—
—
—
0
0
(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection
0
9
0.00
0.00
0.0
2.4
—
—
—
0
0
(3035320) C reactive protein [Mass/volume] in Body fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3015183) Erythrocyte sedimentation rate
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(44806420)
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(1002224) Polysomnography panel
5
50
1.00
0.00
1.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_HERIPOTHUN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HERIPOTHUN | 1.949 [1.41, 2.69] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.339 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 327 females with G6_HERIPOTHUN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HERIPOTHUN | 1.706 [1.3, 2.23] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.051 |
During the follow-up period (1.1.1998 — 31.12.2019), 92 out of 395 males with G6_HERIPOTHUN died.
Mortality risk
Mortality risk for people of age
years, who have G6_HERIPOTHUN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.17% | 0.291% |
| 5 | 1.14% | 2.114% |
| 10 | 2.679% | 5.458% |
| 15 | 5.451% | 10.265% |
| 20 | 9.551% | 16.625% |
Relationships between endpoints
↥Index endpoint: G6_HERIPOTHUN – Other and unspecified neuropathies
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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