Other and unspecified neuropathies

G6_HERIPOTHUN

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G60.8, G60.9 Hospital discharge: ICD-9 — 356[8-9] Cause of death: ICD-10 — G60.8, G60.9 Cause of death: ICD-9 — 356[8-9] 2 out of 7 registries used, show all original rules.	154
4. Check minimum number of events None	154
5. Include endpoints None	154
6. Filter based on genotype QC (FinnGen only)	150

Control definitions (FinnGen only)

Control exclude: G6_POLYNEU

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	G6_HERIPOTHUN
CONTROL_EXCLUDE	G6_POLYNEU
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G60[8-9]
HD_ICD_9	356[8-9]
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G60[8-9]
COD_ICD_9	356[8-9]
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other and unspecified neuropathies based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1396	595	779
Only index persons	972	439	533
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	55.99	55.26	56.05
Only index persons	49.86	48.73	50.80

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	150	66	84
Unadjusted period prevalence (%)	0.03	0.02	0.04
Median age at first event (years)	52.58	47.57	56.52

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
154: Matched controls
1540

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G60.9

ICD-10 Finland

Hereditary and idiopathic neuropathy, unspecified

+∞

83.0

G60.8

ICD-10 Finland

Other hereditary and idiopathic neuropathies

+∞

66.6

G62.9

ICD-10 Finland

Polyneuropathy, unspecified

460.1

62.2

G60.0

ICD-10 Finland

Hereditary motor and sensory neuropathy

+∞

53.3

3569X

ICD-9 Finland

Hereditary and idiopathic peripheral neuropathy, Unspecified

+∞

24.6

G62.8

ICD-10 Finland

Other specified polyneuropathies

+∞

17.0

Z31.5

ICD-10 Finland

Genetic counselling

7.3

15.0

SPAT1229

SPAT

Assessment of need for aid

6.1

13.5

3568X

ICD-9 Finland

Hereditary and idiopathic peripheral neuropathy, Other specified idiopathic peripheral neuropathy

+∞

12.7

N03AE01

ATC

clonazepam; systemic

6.6

12.7

N03AX12

ATC

[U] gabapentin; oral

3.6

10.2

147

A28

ICPC

Limited function/disability NOS

3.5

10.0

154

N03AX16

ATC

[U] pregabalin

3.2

9.5

196

L28

ICPC

Limited function/disability (L)

3.4

9.5

147

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

4.4

9.1

Z50.1

ICD-10 Finland

Other physical therapy

7.2

8.9

R1250

NOMESCO Finland

Evaluation of functional capability

11.0

8.8

M60.8

ICD-10 Finland

Other myositis

95.0

8.5

R5110, ,

SPAT

5.1

8.1

N99

ICPC

Neurological disease other

47.4

7.8

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

3.2

7.6

130

Z01.8

ICD-10 Finland

Other specified special examinations

2.9

7.5

187

N04BC05

ATC

pramipexole; oral

4.2

7.1

N06AA09

ATC

amitriptyline; systemic

3.8

7.0

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

6.7

7.0

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

3.3

6.8

102

W19

ICD-10 Finland

Unspecified fall

3.6

6.8

M60.9

ICD-10 Finland

Myositis, unspecified

23.7

6.8

Z3226

NOMESCO Finland

Physiotherapist

2.8

6.7

177

N39.4

ICD-10 Finland

Other specified urinary incontinence

3.8

6.4

R27.0

ICD-10 Finland

Ataxia, unspecified

27.9

6.3

Z46.8

ICD-10 Finland

Fitting and adjustment of other specified devices

9.2

6.2

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

3.6

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3037522) Nuclear Ab [Titer] in Serum

153

2.77

6.06

1.3

1.4

512.00

568.24

titre

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.89

4.46

2.4

1.8

—

(3031040) Bacteria [#/volume] in Urine by Automated count

107

798

2.12

4.39

5.4

4.2

—

124.43

—

(3002582) Erythrocytes [#/volume] in Urine

389

2.05

4.37

4.0

3.4

11.14

193.98

e6/l

0.58

301

(3030467) Casts [#/volume] in Urine by Automated count

354

2.02

4.11

4.0

3.3

0.18

0.62

e6/l

1.51

267

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.25

4.10

2.3

1.6

—

(3018095) Leukocytes [#/volume] in Urine

444

1.95

3.94

4.5

3.9

77.46

57.27

e6/l

0.15

317

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

445

1.95

3.91

4.8

3.4

—

(3000850) Epithelial cells [#/volume] in Urine

270

2.07

3.90

3.6

2.6

4.10

4.47

e6/l

0.14

240

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

9.09

3.81

1.0

1.1

—

(36304419) Bacteria [Presence] in Urine

339

1.91

3.43

4.1

3.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.64

3.37

1.7

1.3

—

(3023410) Appearance of Cerebral spinal fluid

6.60

3.22

1.1

1.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

572

1.78

3.10

5.8

6.1

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

640

1.78

3.06

4.9

7.1

19.84

11.54

umol/l

0.81

607

(1761482) Bacteria [#/volume] in Urine by Culture

3.74

3.06

5.5

6.3

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

204

2.00

3.04

2.8

3.1

0.80

0.98

e6/l

0.26

113

(3026008) Bacteria identified in Urine by Culture

368

1.82

3.03

4.6

2.9

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

2.87

0.0

1.4

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

591

1.74

2.86

5.8

6.6

1.22

mmol/l

0.08

504

(1616796) Gas panel - Central venous blood

3.74

2.84

3.1

2.9

—

(3037467) Urinalysis macro (dipstick) panel - Urine

104

831

1.77

2.78

5.5

4.1

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

8.56

2.77

1.0

5.2

23.80

32.17

umol/l

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

484

1.73

2.75

2.0

1.9

86.44

93.74

pmol/l

0.82

248

(3022096) Basophils/100 leukocytes in Blood

568

1.71

2.73

6.3

5.5

0.52

0.66

1.58

522

(3016018) Differential panel - Cerebral spinal fluid

7.33

2.56

1.0

1.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.60

2.53

3.6

2.2

—

(3013707) Erythrocyte sedimentation rate by Westergren method

109

896

1.74

2.50

4.5

4.0

12.53

12.11

mm/h

0.10

101

808

(3013115) Eosinophils [#/volume] in Blood

645

1.67

2.48

6.6

5.7

0.16

0.19

e9/l

1.32

566

(3001604) Monocytes [#/volume] in Blood

626

1.66

2.48

6.5

5.3

0.58

e9/l

0.09

533

(3006315) Basophils [#/volume] in Blood

627

1.66

2.46

6.6

5.3

0.04

e9/l

0.55

536

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

3.78

2.40

1.4

1.5

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

3.78

2.40

1.6

1.3

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

3.78

2.40

1.4

1.5

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

6.41

2.39

1.0

—

(3044290) Cell count panel - Cerebral spinal fluid

4.26

2.39

1.3

1.4

—

(3023368) Bacteria identified in Blood by Culture

356

1.70

2.36

5.8

4.5

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.81

2.26

1.7

1.5

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

5.70

2.23

1.0

1.1

—

(21494815) CD4 cells/100 lymphocytes in Specimen

5.70

2.23

1.8

2.0

45.08

28.07

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

5.70

2.23

1.0

1.1

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

371

1.65

2.19

3.2

3.1

802.49

1198.71

ng/l

0.70

307

(3013650) Neutrophils [#/volume] in Blood by Automated count

729

1.61

2.16

7.9

9.9

4.12

4.13

e9/l

0.02

627

(3019309) Folate [Moles/volume] in Red Blood Cells

228

1.76

2.13

1.7

929.24

1184.15

nmol/l

0.71

174

(3021589) Normoblasts [#/volume] in Blood

557

1.59

2.11

12.8

10.1

0.00

e9/l

0.52

450

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

247

1.71

2.05

1.8

1.9

1.36

1.54

mg/l

0.15

193

(3019198) Lymphocytes [#/volume] in Blood

646

1.58

2.05

6.7

5.3

1.77

1.95

e9/l

0.84

571

(3021901) Oxygen saturation in Capillary blood

3.19

2.04

7.3

2.6

—

(3000330) Specific gravity of Urine by Test strip

2.40

2.04

5.8

4.7

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

159

1.85

2.02

8.4

7.1

104.56

104.17

mmol/l

0.13

159

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

3.86

1.95

1.3

1.6

—

(3009261) Glucose [Presence] in Urine by Test strip

594

1.55

1.93

5.6

3.7

0.00

estimate

-0.00

114

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

195

1.74

1.87

2.7

3.4

1.51

2.28

e6/l

0.29

106

(3033705) Calcium.ionized [Moles/volume] in Venous blood

3.63

1.85

4.2

3.4

—

(40760888) Immunoglobulin light chains.free panel - Serum

2.85

1.82

1.3

3.8

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.00

1.73

1.6

1.5

—

(3018418) pH of Serum or Plasma

364

1.55

1.71

2.6

3.7

7.40

7.39

—

(3042936) Bacteria identified in Isolate by Culture

185

1.70

1.67

2.1

1.9

—

(3035350) Ketones [Presence] in Urine by Test strip

590

1.49

1.64

5.7

3.6

0.00

0.01

estimate

0.50

131

(4062490) Immunoglobulin typing, IgG

3.65

1.63

1.0

1.1

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

195

1.67

1.61

3.8

3.4

0.84

0.81

mmol/l

0.60

182

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.07

1.59

6.1

7.2

25.49

24.83

mmol/l

0.18

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

2.36

1.59

1.4

1.8

50.80

35.86

u/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

585

1.47

1.55

8.3

5.1

0.00

estimate

-0.00

123

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

1.54

0.0

1.8

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

529

1.47

1.53

3.8

4.8

34.70

35.38

g/l

0.33

495

(3014111) Lactate [Moles/volume] in Serum or Plasma

103

1.85

1.48

5.0

6.5

1.68

1.50

mmol/l

0.32

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

3.00

1.37

1.2

1.5

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

122

1098

1.53

1.34

4.5

4.4

1.68

1.97

mu/l

3.14

115

986

(3023323) Follitropin [Units/volume] in Serum or Plasma

2.43

1.31

2.9

1.3

16.40

19.75

iu/l

—

(3019150) Specific gravity of Urine by Refractometry

267

1.51

1.29

6.4

3.7

1.02

kg/l

0.29

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

2.35

1.29

1.0

1.2

—

11.84

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.45

1.25

2.7

3.0

5.28

4.87

kpa

—

(3037756) Immunofixation for Serum or Plasma

2.45

1.25

1.2

1.3

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

2.45

1.25

1.5

1.1

—

(3027315) Oxygen [Partial pressure] in Blood

2.45

1.25

2.7

3.0

8.17

8.20

kpa

—

(3000494) Fungus identified in Specimen by Culture

152

1.60

1.17

1.2

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

467

1.39

1.13

6.6

3.8

—

(40768804) Tissue Pathology biopsy report

471

0.69

1.12

2.3

2.1

—

(3000991) Gas panel - Venous blood

105

1.70

1.11

7.2

8.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

148

0.52

1.10

3.1

2.0

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.24

1.09

1.1

1.2

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.24

1.09

1.0

1.1

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

2.06

1.07

1.3

3.1

—

3.98

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

135

0.50

1.04

2.1

1.8

—

(43055120) Cytomegalovirus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

2.31

1.04

1.2

7.5

—

854.00

—

(3025941) Bacteria identified in Stool by Culture

1.83

1.04

1.3

1.2

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

138

1296

1.62

1.03

21.0

16.8

65.65

78.91

umol/l

9.13

138

1296

(3036481) Cortisol [Moles/volume] in Serum or Plasma

100

1.67

1.01

3.4

2.2

286.75

363.42

nmol/l

0.95

(3041096) Erythrocytes [Presence] in Urine by Automated

336

1.39

0.99

4.8

3.5

—

(40758558) Short blood count panel - Blood

327

1.39

0.99

7.7

6.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

142

1.55

0.99

2.2

1.6

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.21

0.99

1.2

1.6

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

2.21

0.99

1.2

1.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

120

0.48

0.98

1.2

1.5

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.93

0.95

1.4

1.6

—

(1761868) Lipid panel - Serum or Plasma

426

0.71

0.93

2.6

3.0

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.19

0.92

1.2

1.6

—

(3022217) INR in Platelet poor plasma by Coagulation assay

568

1.32

0.90

13.5

12.8

1.25

1.30

inr

0.21

175

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

207

1.43

0.87

2.1

2.0

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

125

1165

1.39

0.82

4.1

4.6

6.14

5.98

mmol/l

0.39

115

1052

(3044640) Blood type and Crossmatch panel - Blood

393

1.32

0.81

2.5

2.4

—

(36660697) Celiac disease serology panel - Serum

1.61

0.81

1.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

479

1.30

0.80

4.0

3.8

37.65

47.76

ng/l

0.31

343

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.80

0.0

1.4

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.80

0.0

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.80

0.0

1.4

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.80

0.0

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.80

0.0

1.4

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.80

0.0

1.4

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.69

0.77

1.2

1.1

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

123

1147

1.36

0.77

16.7

13.8

92.88

80.94

ml/min/173m2

4.71

108

932

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

142

1.47

0.77

6.7

8.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

142

1.47

0.77

1.9

1.8

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.77

0.0

1.6

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

258

1.36

0.76

1.6

1.8

525000428.46

420.15

pmol/l

0.48

219

(3011397) Hemoglobin [Presence] in Urine by Test strip

268

1.34

0.74

6.2

3.4

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

2.03

0.73

1.2

1.6

—

(3002385) Erythrocyte distribution width [Ratio]

115

1067

1.31

0.71

21.1

17.3

14.23

14.95

1.01

115

1053

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

1.95

0.71

1.0

1.1

—

(3022313) Gas panel - Capillary blood

1.64

0.70

5.2

4.8

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.81

0.66

1.2

1.3

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

1.81

0.66

1.0

1.2

—

(3003396) Base excess in Arterial blood by calculation

138

1.43

0.66

8.6

6.8

2.41

1.42

mmol/l

0.21

110

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

310

1.30

0.66

2.3

2.0

4.02

3.20

mg/l

0.32

265

(3013512) EKG study

357

1.28

0.65

3.9

4.3

—

(40768795) Lymph node Pathology biopsy report

0.00

0.60

0.0

1.2

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.59

0.0

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.59

0.0

1.4

—

(3033658) Prothrombin time (PT) actual/Normal

315

1.27

0.58

3.9

4.0

83.26

89.78

0.80

310

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.55

0.58

1.8

1.7

—

(40761535) Cells panel - Urine sediment

1.46

0.56

6.1

3.3

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.65

0.56

1.3

1.1

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

402

1.24

0.56

4.0

3.3

2.34

2.35

mmol/l

0.19

351

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.60

0.55

1.3

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.60

0.55

1.3

1.1

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

299

1.27

0.55

2.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

143

0.68

0.50

1.2

1.5

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

881

1.20

0.49

3.9

3.7

14.73

14.74

pmol/l

0.02

790

(3022621) pH of Urine by Test strip

1.50

0.48

4.2

2.2

—

(3025159) Blasts/100 leukocytes in Blood

1.42

0.47

3.5

5.0

—

0.00

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

185

1.29

0.45

1.7

2.2

29.43

30.07

0.24

177

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

140

1.32

0.44

2.0

1.7

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.63

0.43

1.2

1.3

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

1.58

0.42

2.0

1.8

—

0.02

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.58

0.42

1.4

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.41

0.0

1.2

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.41

0.0

1.7

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.41

0.0

1.3

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.41

0.0

1.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.41

0.0

1.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

105

0.65

0.41

1.0

1.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

561

1.18

0.40

3.0

2.7

—

(3019060) Gas panel - Arterial blood

1.40

0.39

9.3

4.1

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.40

0.38

1.4

1.2

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

127

1223

1.22

0.37

20.8

14.6

26.58

24.52

mg/l

0.32

115

986

(4200892) Spirometry reversibility

0.64

0.36

1.4

1.3

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

1.31

0.31

2.8

3.3

80.43

64.13

ml/min/173m2

—

(3020779) Urea [Moles/volume] in Serum or Plasma

103

1.29

0.29

5.1

6.3

7.08

9.01

mmol/l

0.77

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

234

1.19

0.29

4.3

3.3

1188.84

156.27

ng/l

0.42

177

(4035726) Immunohistochemistry procedure

119

0.74

0.28

1.6

1.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

139

1359

1.23

0.27

26.4

21.2

38.54

40.29

1.42

130

1287

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.20

0.25

1.2

1.3

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.33

0.23

1.0

1.3

—

(3009508) Creatinine [Moles/volume] in Urine

386

0.88

0.23

3.2

7.84

7.79

mmol/l

0.02

314

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.29

0.23

1.4

1.8

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

385

1.13

0.22

4.6

21.53

21.06

0.07

190

(3052851) Hemolysis interference index of Serum or Plasma

1.23

0.22

2.0

2.9

—

(3012516) Albumin [Mass/volume] in Urine

343

0.88

0.21

3.2

41.97

77.11

mg/l

0.58

224

(3003327) Ova and parasites identified in Stool by Light microscopy

1.20

0.21

2.2

1.5

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.4

—

(3016750) Collection duration of Urine

0.00

0.21

0.0

2.2

—

497.17

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

16.9

—

1939.18

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.4

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.21

0.0

2.3

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.21

0.0

1.0

—

(3044889) 12 lead EKG panel

842

1.11

0.21

4.2

3.8

—

(3011648) Oxygen content in Venous blood

0.00

0.21

0.0

4.3

—

11.37

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

7.69

—

(40768806) Pleura Pathology biopsy report

0.00

0.21

0.0

2.3

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.21

0.0

1.1

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.21

0.0

1.4

—

227.72

—

(40768441) Liver Pathology biopsy report

0.00

0.21

0.0

1.6

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.21

0.0

1.0

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.26

0.20

2.5

2.2

—

(3020891) Body temperature

1.26

0.20

14.5

5.3

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.20

0.0

1.1

—

(4146454) Self-monitoring of blood glucose

0.00

0.20

0.0

2.1

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.20

0.0

2.0

—

33.50

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.20

0.0

1.1

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

204

1.15

0.19

1.5

1.3

21.80

38.41

iu/ml

—

(3049717) Cytology report of Urine Cyto stain

1.16

0.19

3.7

2.8

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.16

0.19

2.8

2.6

—

(3019225) pH of Specimen

109

1.21

0.19

3.1

4.4

—

(3002256) Pathology report gross observation

148

1.17

0.17

1.2

1.3

—

(3003694) ABO and Rh group [Type] in Blood

328

0.89

0.17

1.6

1.4

—

(3029937) Albumin [Presence] in Urine by Test strip

332

1.11

0.17

6.3

3.7

0.00

estimate

-0.00

116

(46235355) HIV 1 and 2 tests - Meaningful Use set

223

0.88

0.15

1.3

1.7

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

123

1204

1.11

0.15

4.8

5.0

2.74

2.70

mmol/l

0.16

112

1100

(40768797) Stomach Pathology biopsy report

160

1.14

0.14

1.1

1.2

—

(21494755) Public health laboratory ask at order entry panel

109

0.81

0.13

1.6

1.5

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

524

1.08

0.13

2.4

2.7

118.21

126.37

ug/l

0.17

475

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

486

1.07

0.12

4.8

5.1

1.86

2.74

ug/l

0.65

433

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

111

1133

0.93

0.12

4.3

4.0

1.36

1.28

mmol/l

0.48

100

1030

(3007164) IgA [Mass/volume] in Serum or Plasma

250

1.10

0.12

1.5

1.4

2.23

2.70

g/l

1.09

151

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

126

0.86

0.12

4.3

3.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

222

1.10

0.11

1.9

1.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

125

0.87

0.10

1.4

1.6

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.09

0.09

1.8

1.6

—

(3026493) Urate [Moles/volume] in Serum or Plasma

323

1.07

0.08

1.8

2.9

26902.21

7022.22

umol/l

0.53

273

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

0.81

0.08

1.0

1.2

—

139.20

iu/ml

—

(3000492) Spirometry study

112

0.89

0.07

1.4

—

(3022948) Iron [Moles/volume] in Serum or Plasma

206

1.08

0.07

1.9

2.3

10.09

13.66

umol/l

1.20

189

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.86

0.07

1.4

—

(40761511) CBC panel - Blood by Automated count

126

1274

0.94

0.06

16.3

13.4

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

151

0.92

0.05

4.1

4.3

31.29

32.29

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

119

1177

1.05

0.05

4.6

4.5

4.57

4.56

mmol/l

0.03

109

1083

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

774

0.96

0.05

2.8

3.0

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

189

1.07

0.05

1.4

1.3

0.98

8.85

u/ml

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

116

1171

0.96

0.04

4.4

1.38

1.44

mmol/l

0.87

107

1067

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

113

1119

1.04

0.03

5.8

5.9

39.70

40.19

mmol/mol

0.19

104

1042

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

281

1.04

0.02

3.3

3.1

0.63

0.74

ug/l

0.42

183

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

182

1.05

0.02

1.7

2.4

25.15

23.54

0.05

158

(3022145) Colonoscopy Study observation

133

1.06

0.01

1.1

1.3

—

(3020682) Albumin/Creatinine [Ratio] in Urine

367

0.98

0.01

3.3

3.8

4.93

9.87

mg/mmol

0.96

233

(40761536) Microorganisms panel - Urine sediment

106

1.04

0.00

3.5

3.7

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

313

0.99

0.00

1.7

1.6

1.41

1.30

mmol/l

0.26

253

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

278

1.01

0.00

1.4

1.2

0.78

1.60

u/ml

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

65.63

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

6.2

—

45.67

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.0

—

6.12

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

0.0

1.7

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.89

0.00

2.0

1.9

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.2

—

(3012565) Volume of 24 hour Urine

0.00

0.0

2.5

—

2324.17

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.2

—

(3005011) Chlamydia sp Ab [Titer] in Serum

0.00

0.0

1.4

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.4

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

38.83

—

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

0.00

0.0

1.8

—

(3011436) Histone Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

-0.00

0.0

1.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.4

—

(3036603) Volume of Urine

0.00

-0.00

0.0

2.3

—

1530.00

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.0

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.4

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.02

-0.00

10.0

7.8

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

6.1

—

226.57

—

(3047189) Immunofixation for 24 hour Urine

0.00

-0.00

0.0

1.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

170

1.00

-0.00

1.2

1.6

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

-0.00

0.0

1.0

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.1

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

6.9

—

102.43

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.8

—

(1002224) Polysomnography panel

1.00

-0.00

1.0

1.1

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

150

1.00

-0.00

1.4

1.3

—

(3008898) HLA-B27 [Presence]

0.96

-0.00

1.2

1.1

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.4

—

1.27

—

(40758292) HTLV I+II Ab panel - Serum

0.00

-0.00

0.0

1.8

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.6

—

(3018658) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

8.78

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

3.00

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_HERIPOTHUN and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_HERIPOTHUN	1.949 [1.41, 2.69]	< 0.001
Birth year	0.996 [0.99, 1.0]	0.339

During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 327 females with G6_HERIPOTHUN died.

Males

Parameter	HR [95% CI]	p-value
G6_HERIPOTHUN	1.706 [1.3, 2.23]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.051

During the follow-up period (1.1.1998 — 31.12.2019), 92 out of 395 males with G6_HERIPOTHUN died.

Mortality risk

Mortality risk for people of age

years, who have G6_HERIPOTHUN.

N-year risk	Females	Males
1	0.17%	0.291%
5	1.14%	2.114%
10	2.679%	5.458%
15	5.451%	10.265%
20	9.551%	16.625%

Relationships between endpoints

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Index endpoint: G6_HERIPOTHUN – Other and unspecified neuropathies

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other and unspecified neuropathies

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints