spinal cord disease: A disease involving the spinal cord.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
440 |
4. Check minimum number of eventsNone |
440 |
5. Include endpointsNone |
440 |
6. Filter based on genotype QC (FinnGen only) |
440 |
Control definitions (FinnGen only)
- Control exclude
- G6_NERPLEX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G54
- Name in latin
- Morbositates radicum nervorum lumbosacralium non alibi classificatae
Similar endpoints
↥List of similar endpoints to
Lumbosacral root disorders, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3586 | 1888 | 1683 |
| Only index persons | 3295 | 1778 | 1517 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.05 |
| Only index persons | 0.06 | 0.07 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 57.09 | 56.62 | 57.51 |
| Only index persons | 56.44 | 55.99 | 56.96 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 440 | 252 | 188 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.08 |
| Median age at first event (years) | 54.68 | 52.13 | 58.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 408
- Matched controls
- 4079
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G54.4
ICD-10 Finland
Lumbosacral root disorders, not elsewhere classified
+∞
323.0
335
*
XA402
NOMESCO Finland
ENMG
200.6
233.2
226
25
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
10.2
77.4
177
285
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
8.2
73.2
202
435
N03AX16
ATC
pregabalin; oral
7.6
72.9
222
553
3534A
ICD-9 Finland
Nerve root and plexus disorders, Lumbosacral root lesions, not elsewhere classified[RADICULOPATHIA LUMBOSACRALIS]
+∞
68.7
64
*
M48.0
ICD-10 Finland
Spinal stenosis
8.1
53.4
135
234
N03AX12
ATC
gabapentin; oral
7.1
52.7
150
309
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
7.9
51.3
131
229
M54.4
ICD-10 Finland
Lumbago with sciatica
6.1
46.7
150
354
G55.1*M51.9
ICD-10 Finland
Nerve root and plexus compressions in intervertebral disc disorders (M50-M51+)
488.3
45.2
44
*
M54.5
ICD-10 Finland
Low back pain
4.6
43.9
214
790
M54.1
ICD-10 Finland
Radiculopathy
14.9
40.9
70
56
N02AX02
ATC
tramadol; systemic, rectal
3.8
35.7
244
1148
G56.0
ICD-10 Finland
Carpal tunnel syndrome
17.0
34.2
55
37
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
65.5
31.6
36
6
Z01.9
ICD-10 Finland
Special examination, unspecified
8.1
30.8
73
107
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
8.3
30.5
71
101
ACC51
NOMESCO Finland
Release of median nerve
325.2
30.2
30
*
N06AA09
ATC
amitriptyline; systemic
5.3
26.8
89
203
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
12.2
26.7
49
45
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
8.7
26.4
59
78
N02AA05
ATC
oxycodone; systemic
4.3
26.1
109
316
L03
ICPC
Low back symptom/complaint
3.5
24.6
144
552
N06AX21
ATC
duloxetine; oral
5.2
23.8
80
184
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
5.6
23.1
71
147
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.9
22.5
230
1271
M51.9
ICD-10 Finland
Intervertebral disc disorder, unspecified
31.1
22.2
29
10
M79.6
ICD-10 Finland
Pain in limb
2.8
20.0
181
910
M01AH05
ATC
etoricoxib; oral
2.7
19.8
283
1851
R1240
NOMESCO Finland
Social assessment of need and possibilities of rehabilitation
20.7
19.8
29
15
Z50.1
ICD-10 Finland
Other physical therapy
6.1
19.6
55
101
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
4.6
19.3
72
183
M17.1
ICD-10 Finland
Other primary gonarthrosis
3.1
19.0
127
521
A02BC03
ATC
lansoprazole; oral
2.8
18.8
165
804
M54.9
ICD-10 Finland
Dorsalgia, unspecified
4.1
18.5
77
217
A02BC05
ATC
esomeprazole; systemic
2.6
18.3
208
1174
L28
ICPC
Limited function/disability (L)
3.5
18.1
96
330
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.8
17.9
82
252
N02AJ06
ATC
codeine and paracetamol; systemic
2.6
17.6
181
961
M03BC01
ATC
orphenadrine (citrate); systemic
2.9
17.3
127
550
M03BX02
ATC
tizanidine; oral
2.5
17.0
278
1878
M01AB05
ATC
diclofenac; systemic, rectal
2.6
16.9
301
2125
M43.1
ICD-10 Finland
Spondylolisthesis
6.5
16.7
44
74
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
4.2
16.7
67
182
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
8.3
16.2
36
47
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
7.3
16.2
39
58
A29
ICPC
General symptom/complaint other
3.6
16.1
78
250
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.5
16.0
169
897
M01AC06
ATC
meloxicam; systemic, rectal
2.4
15.6
183
1023
M47.9
ICD-10 Finland
Spondylosis, unspecified
9.3
15.5
32
37
A02BC02
ATC
pantoprazole; systemic
2.5
15.5
298
2132
WX702
NOMESCO Finland
Supraglottic ventilation device
5.4
15.2
46
93
R29
ICPC
Respiratory symptom/complaint other
5.4
15.2
46
93
M01AH01
ATC
celecoxib; oral (coxibs)
2.8
15.0
110
471
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
83.1
14.7
16
*
N06AX16
ATC
venlafaxine; oral
3.3
14.6
79
273
XA420
NOMESCO Finland
Extensive sleep examination
15.1
14.2
23
16
Z00.6
ICD-10 Finland
Examination for normal comparison and control in clinical research programme
9.9
14.2
28
30
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
5.6
13.7
40
77
N02BE01
ATC
paracetamol; systemic, rectal
3.1
13.7
365
2995
S02.5
ICD-10 Finland
Fracture of tooth
8.2
13.6
30
39
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
3.9
13.4
57
163
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
41.5
13.2
16
*
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
4.6
13.0
46
110
M25.5
ICD-10 Finland
Pain in joint
2.4
12.7
132
678
XG410
NOMESCO Finland
Flow-volume spirometry
5.7
12.6
36
68
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
6.1
12.5
34
60
Z76.0
ICD-10 Finland
Issue of repeat prescription
2.9
12.5
81
317
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
27.7
12.1
16
6
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.4
12.1
117
577
L15
ICPC
Knee symptom/complaint
2.6
12.1
97
433
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.3
12.0
139
749
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
8.8
12.0
25
30
M96.1
ICD-10 Finland
Postlaminectomy syndrome, not elsewhere classified
48.1
11.9
14
*
M54.3
ICD-10 Finland
Sciatica
4.6
11.8
41
97
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.3
11.6
61
207
R1280
NOMESCO Finland
Evaluation of the need for vocational rehabilitation
+∞
11.5
11
*
L29
ICPC
Musculoskeletal sympt/complt other
3.9
11.5
48
135
A06AD11
ATC
lactulose; oral
2.8
11.3
81
335
KMAK
NOMESCO Finland
NA
2.1
11.3
214
1421
M01AE02
ATC
naproxen; oral, rectal
2.1
11.3
248
1751
J01DB01
ATC
cefalexin; oral
2.4
11.2
339
2742
S59
ICPC
Skin, Other therap proced/minor surg NEC
13.2
11.2
19
15
M01AX05
ATC
glucosamine; oral
2.4
11.2
106
514
M01AH02
ATC
rofecoxib; oral
2.9
11.1
74
293
R07.4
ICD-10 Finland
Chest pain, unspecified
2.3
11.0
129
693
NG1EA
SPAT
NA
44.6
11.0
13
*
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.6
10.9
90
405
XX9BW
NOMESCO Finland
Submitting image material and/or investigation material to authority or other institution
10.0
10.9
21
22
S02.51
ICD-10 Finland
Fracture of tooth, open
3.1
10.8
61
217
ZXA00
NOMESCO Finland
Right side
2.2
10.7
128
694
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
6.9
10.7
26
40
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
5.9
10.6
29
52
K29
ICPC
Cardiovascular sympt/complt other
5.3
10.6
32
65
K30
ICD-10 Finland
Functional dyspepsia
3.0
10.4
63
235
9211
FHL
Exploration or removal of diskusprolapse
6.9
10.4
25
38
GD1AA
SPAT
NA
3.9
10.3
43
121
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
2.9
10.3
66
255
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.2
10.3
133
744
ZXA05
NOMESCO Finland
Left side
2.2
10.2
121
651
A28
ICPC
Limited function/disability NOS
2.6
10.1
77
330
S29
ICPC
Skin symptom/complaint other
2.5
10.0
82
367
R43
ICPC
Respiratory, Other diagnostic procedure
17.2
9.9
15
9
M01AE01
ATC
ibuprofen; systemic, rectal
2.7
9.9
366
3127
G54.0
ICD-10 Finland
Brachial plexus disorders
26.8
9.9
13
5
J45.9
ICD-10 Finland
Asthma, unspecified
2.5
9.8
86
400
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.0
9.7
59
219
H02AB06
ATC
prednisolone; systemic
1.9
9.6
204
1383
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
18.1
9.5
14
8
ABC99
NOMESCO Finland
Other decompressive operation on spinal cord or nerve root
30.8
9.4
12
*
3534B
ICD-9 Finland
Nerve root and plexus disorders, Lumbosacral root lesions, not elsewhere classified[SYNDROMA CAUDAE EQUINAE]
+∞
9.4
9
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.0
9.3
168
1070
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.9
9.2
197
1331
G56.2
ICD-10 Finland
Lesion of ulnar nerve
16.0
9.1
14
9
XG404
NOMESCO Finland
Peak expiratory flow (PEF) measurement
16.0
9.1
14
9
J01FA09
ATC
clarithromycin; systemic
2.0
9.0
145
880
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.9
9.0
211
1473
M01AX17
ATC
nimesulide; oral
2.1
9.0
116
644
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
5.4
8.9
26
51
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.1
8.9
50
176
Z02.7
ICD-10 Finland
Issue of medical certificate
3.8
8.9
37
104
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
5.6
8.9
25
47
M47.82
ICD-10 Finland
Other spondylosis, cervical region
4.5
8.8
30
70
M70.6
ICD-10 Finland
Trochanteric bursitis
2.7
8.6
63
262
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.5
8.6
40
124
M01AE11
ATC
tiaprofenic acid; oral, rectal
4.1
8.6
32
82
M79.0
ICD-10 Finland
Rheumatism, unspecified
4.7
8.5
28
63
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
6.5
8.4
21
34
35399
ICD-8 Finland
Sciatica
+∞
8.4
8
*
G54.2
ICD-10 Finland
Cervical root disorders, not elsewhere classified
+∞
8.4
8
*
R52.2
ICD-10 Finland
Other chronic pain
5.6
8.3
23
43
R96
ICPC
Asthma
3.1
8.3
44
151
WX704
NOMESCO Finland
Intubation
3.2
8.2
42
140
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.5
8.2
64
278
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.9
8.2
33
91
TAB20
NOMESCO Finland
Epidural puncture
17.6
8.1
12
7
B01AB10
ATC
tinzaparin; parenteral
3.1
8.1
45
156
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
7.5
8.0
18
25
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.1
8.0
105
583
S18
ICPC
Laceration/cut
1.9
7.9
170
1133
WZA90
NOMESCO Finland
Other doctors statement
2.1
7.9
100
547
H57.1
ICD-10 Finland
Ocular pain
5.5
7.8
22
42
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
6.1
7.8
20
34
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.5
7.8
66
297
JN3AE
SPAT
NA
7.7
7.7
17
23
UKC02
NOMESCO Finland
Cystoscopy
2.3
7.7
77
378
SAA01
NOMESCO Finland
Simple examination of mouth
1.8
7.6
271
2123
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
7.6
127
773
S06.0
ICD-10 Finland
Concussion
2.8
7.5
50
197
R51.80
ICD-10 Finland
Headache
2.4
7.4
62
278
XG412
SPAT
NA
81.5
7.4
8
*
G57.8
ICD-10 Finland
Other mononeuropathies of lower limb
81.5
7.4
8
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.7
7.4
53
217
G51.0
ICD-10 Finland
Bell palsy
+∞
7.3
7
*
N05CD07
ATC
temazepam; oral
2.4
7.3
64
296
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
7.3
63
287
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
7.5
7.3
16
22
N03AX09
ATC
lamotrigine; oral
4.3
7.1
25
61
G45.4
ICD-10 Finland
Transient global amnesia
5.3
7.0
20
39
P03
ICPC
Feeling depressed
3.1
7.0
37
127
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
2.3
7.0
64
301
J01DA01
ATC
[U] cefalexin; systemic
1.8
7.0
254
1975
R05
ICPC
Cough
2.0
6.9
94
527
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
14.1
6.9
11
8
NE1AA
SPAT
NA
14.1
6.9
11
8
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.5
6.9
56
247
N05CF01
ATC
zopiclone; oral
1.8
6.9
138
888
Z98.8
ICD-10 Finland
Other specified postsurgical states
9.5
6.8
13
14
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
4.9
6.8
21
45
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.4
6.8
58
263
G55.2*M47.9
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
40.7
6.8
8
*
R52.1
ICD-10 Finland
Chronic intractable pain
17.0
6.8
10
6
UJF32
NOMESCO Finland
Coloscopy
1.9
6.8
112
675
M54.6
ICD-10 Finland
Pain in thoracic spine
3.3
6.7
32
102
N03AE01
ATC
clonazepam; systemic
3.3
6.7
32
102
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
4.4
6.7
23
55
RTGOM
NOMESCO Finland
NA
22.9
6.7
9
*
J01MA02
ATC
ciprofloxacin; systemic
1.8
6.7
164
1129
P01
ICPC
Feeling anxious/nervous/tense
3.2
6.6
33
109
B01AX05
ATC
fondaparinux; parenteral
12.5
6.6
11
9
K02.1
ICD-10 Finland
Caries of dentine
1.7
6.6
214
1596
ND2AA
SPAT
NA
5.2
6.6
19
38
M72.2
ICD-10 Finland
Plantar fascial fibromatosis
2.9
6.5
38
139
R5140
NOMESCO Finland
Monitoring the use of the aid
2.5
6.5
53
234
P01AB01
ATC
metronidazole; oral, rectal
1.7
6.4
162
1116
Z09.4
ICD-10 Finland
Follow-up examination after treatment of fracture
3.3
6.4
31
100
J01CA04
ATC
amoxicillin; systemic
1.8
6.4
316
2662
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.7
6.4
219
1652
N42.9
ICD-10 Finland
Disorder of prostate, unspecified
6.7
6.4
15
23
M24.2
ICD-10 Finland
Disorder of ligament
8.3
6.4
13
16
M50.3
ICD-10 Finland
Other cervical disc degeneration
5.7
6.4
17
31
D29
ICPC
Digestive symptom/complaint other
6.1
6.4
16
27
XF404
NOMESCO Finland
Ambulatory ECG
2.6
6.3
47
198
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
2.0
6.3
87
487
G55.2
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
+∞
6.3
6
*
L86
ICPC
Back syndrome with radiating pain
3.4
6.3
29
91
WX110
NOMESCO Finland
Local anesthesy
1.7
6.3
261
2082
M02AA07
ATC
piroxicam; topical
1.7
6.1
152
1041
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
2.9
6.1
36
133
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.0
6.1
81
449
SFA00
NOMESCO Finland
Small filling
2.3
6.1
54
251
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
2.7
6.1
39
152
R07.3
ICD-10 Finland
Other chest pain
2.5
6.0
46
198
L13
ICPC
Hip symptom/complaint
2.1
6.0
65
331
C07AB07
ATC
bisoprolol; oral
1.7
6.0
190
1395
Mortality – FinRegistry
↥Association
Association between endpoint G6_LSROOT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_LSROOT | 1.109 [0.93, 1.32] | 0.251 |
| Birth year | 0.998 [0.99, 1.01] | 0.698 |
During the follow-up period (1.1.1998 — 31.12.2019), 198 out of 1477 females with G6_LSROOT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_LSROOT | 1.121 [0.94, 1.34] | 0.205 |
| Birth year | 0.989 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 241 out of 1304 males with G6_LSROOT died.
Mortality risk
Mortality risk for people of age
years, who have G6_LSROOT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.112% | 0.173% |
| 5 | 0.749% | 1.307% |
| 10 | 1.701% | 3.452% |
| 15 | 3.364% | 6.466% |
| 20 | 6.176% | 10.951% |
Relationships between endpoints
↥Index endpoint: G6_LSROOT – Lumbosacral root disorders, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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