obsolete_muscular dystrophy: ['An atrophic muscular disease that causes progressive weakness and degeneration of skeletal muscles used during voluntary movement.']
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
293 |
4. Check minimum number of eventsNone |
293 |
5. Include endpointsNone |
293 |
6. Filter based on genotype QC (FinnGen only) |
283 |
Control definitions (FinnGen only)
- Control exclude
- G6_MYONEU
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G71
- Name in latin
- Dystrophia musculorum (progressiva hereditaria)
Similar endpoints
↥List of similar endpoints to
Muscular dystrophy
based on the number of shared cases.
Similar with more cases:
- Diseases of the myoneural junction and muscle
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2432 | 1004 | 1402 |
| Only index persons | 1905 | 851 | 1054 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.04 |
| Only index persons | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 41.20 | 48.93 | 35.53 |
| Only index persons | 44.75 | 49.50 | 40.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 283 | 148 | 135 |
| Unadjusted period prevalence (%) | 0.06 | 0.05 | 0.06 |
| Median age at first event (years) | 52.09 | 53.37 | 50.68 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 293
- Matched controls
- 2930
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G71.08
ICD-10 Finland
Other muscular dystrophy
+∞
254.9
206
*
G72.9
ICD-10 Finland
Myopathy, unspecified
+∞
90.4
82
*
Z31.5
ICD-10 Finland
Genetic counselling
13.5
81.2
89
92
G71.9
ICD-10 Finland
Primary disorder of muscle, unspecified
+∞
67.3
62
*
G71.00
ICD-10 Finland
Muscular dystrophy benign [Becker]
+∞
63.9
59
*
R1250
NOMESCO Finland
Evaluation of functional capability
14.2
47.3
46
38
G71.8
ICD-10 Finland
Other primary disorders of muscles
+∞
40.6
38
*
NJ3CG
NOMESCO Finland
Extensive MRI examination of extremities with median high magnet
+∞
36.2
34
*
G71.0
ICD-10 Finland
Muscular dystrophy
+∞
35.1
33
*
G71.06
ICD-10 Finland
Muscular dystrophy severe [Duchenne]
+∞
32.9
31
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
6.2
30.5
59
114
G72.8
ICD-10 Finland
Other specified myopathies
+∞
29.7
28
*
SPAT1229
SPAT
Assessment of need for aid
6.4
26.9
49
89
L28
ICPC
Limited function/disability (L)
4.3
26.5
88
267
G71.02
ICD-10 Finland
Muscular dystrophy facioscapulohumeral
+∞
26.5
25
*
G71.11
ICD-10 Finland
Dystrophia myotonica [Steinert]
+∞
26.5
25
*
G71.03
ICD-10 Finland
Muscular dystrophy autosomal recessive, childhood type, resembling Duchenne or Becker
+∞
25.4
24
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
4.5
24.5
72
198
NXL00
NOMESCO Finland
Biopsy of muscle
+∞
24.3
23
*
NJ3BG
NOMESCO Finland
MRI examination of extremities with high intensity magnet
124.3
21.9
23
*
3591A
ICD-9 Finland
Muscular dystrophies and other myopathies, Hereditary progressive muscular dystrophy
+∞
21.1
20
*
J96.1
ICD-10 Finland
Chronic respiratory failure
20.2
20.9
31
17
N99
ICPC
Neurological disease other
23.7
19.9
28
13
A28
ICPC
Limited function/disability NOS
3.7
18.7
72
238
R5110, ,
SPAT
5.6
17.9
36
71
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.2
15.8
78
299
33030
ICD-8 Finland
Hereditary neuromuscular disorders, Progressive muscular dystrophy
+∞
15.8
15
*
G71.18
ICD-10 Finland
Other myotonic disease
+∞
15.8
15
*
G71.25
ICD-10 Finland
Congenital muscular dystrophy NOS
+∞
15.8
15
*
Z50.1
ICD-10 Finland
Other physical therapy
5.2
14.6
32
68
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
12.3
14.6
26
23
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.7
14.5
36
85
XF404
NOMESCO Finland
Ambulatory ECG
4.0
14.4
45
127
L99
ICPC
Musculoskeletal disease other
13.6
14.2
24
19
M60.9
ICD-10 Finland
Myositis, unspecified
56.2
14.0
16
*
Z3226
NOMESCO Finland
Physiotherapist
2.8
13.7
87
381
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.7
13.1
46
141
L19
ICPC
Muscle symptom/complaint NOS
10.0
12.8
25
27
G71.12
ICD-10 Finland
Myotonia congenita
+∞
12.6
12
*
N18
ICPC
Paralysis/weakness
11.8
11.7
21
19
N28
ICPC
Limited function/disability (N)
20.0
11.7
17
9
G71.28
ICD-10 Finland
Other congenital myopathy
+∞
11.5
11
*
NGA20
NOMESCO Finland
Exploration of soft tissue knee or lower leg, open
62.3
10.7
12
*
R4130
NOMESCO Finland
Speech therapy
5.7
10.6
20
37
I42.0
ICD-10 Finland
Dilated cardiomyopathy
9.3
10.5
21
24
R4110
NOMESCO Finland
Physiotherapy
2.3
10.2
105
567
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.4
10.2
88
440
XF400
NOMESCO Finland
ECG with 12 standard connections
2.6
9.8
66
293
R13
ICD-10 Finland
Dysphagia
3.6
9.6
33
99
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.7
9.5
59
251
M62.9
ICD-10 Finland
Disorder of muscle, unspecified
31.2
9.5
12
*
M41.4
ICD-10 Finland
Neuromuscular scoliosis
103.2
9.5
10
*
G12.1
ICD-10 Finland
Other inherited spinal muscular atrophy
+∞
9.4
9
*
33098
ICD-8 Finland
Hereditary neuromuscular disorders, Alii definiti
+∞
9.4
9
*
G71.3
ICD-10 Finland
Mitochondrial myopathy, not elsewhere classified
+∞
9.4
9
*
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
4.3
9.2
24
59
R4120
NOMESCO Finland
Occupational therapy
3.3
8.9
35
115
M60.8
ICD-10 Finland
Other myositis
92.6
8.5
9
*
Z99.1
ICD-10 Finland
Dependence on respirator
+∞
8.4
8
*
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.1
8.3
37
131
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
8.3
75
380
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.1
8.2
35
121
WX1PA
NOMESCO Finland
Total body mineral density measurement with Dual energy X-ray absorptiometry (DXA)
34.4
8.1
10
*
N29
ICPC
Neurological sympt/complt other
11.2
7.9
14
13
G71.01
ICD-10 Finland
Muscular dystrophy benign scapuloperoneal with early contractures [Emery-Dreifuss]
+∞
7.3
7
*
H02AB13
ATC
deflazacort; oral
+∞
7.3
7
*
H02AB09
ATC
hydrocortisone; systemic
4.3
7.2
19
47
S72.4
ICD-10 Finland
Fracture of lower end of femur
30.8
7.2
9
*
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
7.3
7.1
16
23
Z3229
NOMESCO Finland
Other healthcare associate professional
2.8
6.8
36
140
M33.2
ICD-10 Finland
Polymyositis
41.0
6.8
8
*
I42.8
ICD-10 Finland
Other cardiomyopathies
41.0
6.8
8
*
G71.1
ICD-10 Finland
Myotonic disorders
41.0
6.8
8
*
XG466
NOMESCO Finland
Sleep oxymetry
5.6
6.6
18
34
R4190
NOMESCO Finland
Nutritional therapy
3.2
6.4
25
82
RS142, ,
NOMESCO Finland
18.5
6.3
9
5
NJ3DG
NOMESCO Finland
Very extensive MRI examination of extremities with high intensity magnet
+∞
6.3
6
*
G71
ICD-10 Finland
Primary disorders of muscles
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
25
12
22.64
17.62
1.8
1.2
8.76
8.67
u/l
0.01
19
12
123
621
2.69
14.83
3.3
3.3
1531.41
1165.36
ng/l
0.21
106
513
53
174
3.50
13.63
3.1
2.6
159.41
210.57
ng/l
0.39
44
154
166
1151
2.02
7.93
7.0
8.5
1.22
1.22
mmol/l
0.04
147
1001
13
11
12.30
7.65
4.7
3.5
71.46
176.64
ug/l
1.03
13
11
228
1803
2.19
7.27
6.1
7.6
80.98
83.89
u/l
0.25
215
1683
79
438
2.10
6.84
4.1
3.7
86.40
192.44
ng/l
1.19
65
328
47
213
2.44
6.57
5.1
9.7
1.44
1.33
mmol/l
0.32
47
208
58
290
2.25
6.48
3.5
8.0
104.60
104.06
mmol/l
0.46
58
290
9
5
18.50
6.30
2.4
2.0
—
—
—
0
0
51
246
2.30
6.19
4.2
10.6
1.23
1.09
mmol/l
0.07
42
209
150
1068
1.83
6.02
7.0
8.0
1.21
1.22
mmol/l
0.51
140
980
28
103
2.90
5.88
3.9
11.5
1.20
1.35
mg/l
0.60
28
98
116
777
1.82
5.58
2.7
3.4
2.36
2.36
mmol/l
0.28
104
682
138
975
1.79
5.54
3.3
5.4
35.94
35.95
g/l
0.01
131
919
103
680
1.79
5.12
4.0
3.3
0.56
0.41
e6/l
0.23
85
510
70
421
1.87
4.65
3.2
3.0
1.07
0.90
e6/l
0.20
48
233
50
269
2.04
4.59
5.4
7.3
6.21
5.85
kpa
1.24
50
263
183
1453
1.69
4.46
6.4
10.1
3.90
4.04
e9/l
0.33
159
1259
49
269
1.99
4.24
5.4
7.3
2.30
1.87
mmol/l
0.41
43
222
40
207
2.08
4.06
6.3
6.1
1.56
1.71
mmol/l
0.10
30
149
118
857
1.63
3.93
4.0
3.4
—
—
—
0
0
41
217
2.03
3.93
6.3
5.9
5.33
5.14
kpa
0.79
41
206
43
232
2.00
3.91
5.2
7.2
4.97
4.62
kpa
0.69
43
226
64
394
1.80
3.90
2.0
2.9
2.46
2.45
mmol/l
0.29
55
346
32
159
2.14
3.61
1.4
1.2
97.08
161.98
iu/ml
0.60
12
62
27
126
2.26
3.54
5.3
6.6
9.51
9.00
kpa
0.82
27
121
246
2182
1.79
3.37
12.6
12.3
102.33
83.24
ml/min/173m2
10.62
208
1750
152
1205
1.54
3.32
4.7
6.7
55.55
55.99
%
0.16
145
1137
153
1219
1.53
3.24
4.9
6.9
28.97
28.99
%
0.01
147
1150
128
981
1.54
3.24
3.9
2.6
73.43
75.33
nmol/l
0.35
116
857
19
82
2.41
2.98
2.4
1.8
7.79
8.17
u/l
0.04
12
63
36
201
1.90
2.98
3.8
10.7
125.47
122.61
g/l
0.34
36
195
169
1391
1.51
2.97
5.1
5.5
6.31
6.63
mmol/l
1.30
163
1301
210
1818
1.55
2.84
4.4
3.7
15.39
14.65
pmol/l
4.01
195
1639
59
387
1.66
2.84
3.5
3.3
5.62
2.35
e6/l
0.85
38
203
130
1023
1.49
2.79
12.0
11.7
1.31
1.22
inr
0.32
34
296
38
221
1.83
2.78
4.9
9.0
7.40
8.18
mmol/l
0.30
38
211
151
1227
1.48
2.75
5.0
7.1
12.76
12.66
umol/l
0.02
143
1160
59
391
1.64
2.73
1.6
1.7
1138.26
1195.09
nmol/l
0.18
45
286
262
2409
1.83
2.62
14.8
13.6
20.06
21.99
mg/l
0.44
221
1848
23
115
2.09
2.59
4.0
5.4
0.58
0.65
%
0.36
23
115
78
568
1.51
2.39
2.0
2.3
2.91
3.21
mg/l
0.53
60
487
15
65
2.38
2.35
2.0
2.5
3.49
3.80
mmol/l
0.98
15
59
23
120
1.99
2.33
4.1
5.2
1.30
1.27
%
0.07
23
120
110
862
1.44
2.32
1.9
2.0
97.36
95.91
pmol/l
0.12
61
437
74
539
1.50
2.26
1.8
2.6
—
—
—
0
0
55
378
1.56
2.18
1.8
1.8
—
—
—
0
0
10
36
2.84
2.16
1.1
1.2
—
—
—
0
0
107
853
1.40
2.00
3.3
3.5
47.07
43.21
ng/l
0.09
82
593
137
1141
1.38
1.96
4.0
3.6
0.00
0.00
estimate
-0.00
19
194
9
33
2.78
1.95
1.0
1.0
—
—
—
0
0
239
2197
1.48
1.82
5.3
4.4
1.95
1.90
mu/l
0.27
220
1996
9
35
2.62
1.81
1.0
1.0
—
—
—
0
0
6
18
3.38
1.75
1.0
1.0
—
—
—
0
0
8
30
2.71
1.73
1.0
1.0
—
—
—
0
0
134
1129
1.34
1.72
5.7
4.9
0.00
0.00
estimate
-0.00
20
212
125
1046
1.34
1.67
2.1
2.7
—
—
—
0
0
15
77
2.00
1.62
2.1
1.8
—
—
—
0
0
133
1129
1.33
1.59
4.0
3.6
0.00
0.00
estimate
0.50
20
223
197
1770
1.34
1.58
4.6
4.1
10.37
11.20
mm/h
0.48
187
1615
233
2153
1.40
1.53
5.4
5.6
38.41
39.87
mmol/mol
1.69
218
2009
7
28
2.54
1.46
1.3
1.4
0.15
0.28
nmol/l
—
7
21
16
273
0.56
1.44
2.5
2.1
—
—
—
0
0
5
16
3.16
1.44
4.4
1.5
1.84
3.84
mg/l
—
5
16
5
16
3.16
1.44
2.6
2.4
489.60
582.50
ml
—
5
8
15
82
1.87
1.38
2.3
2.0
—
—
—
0
0
15
83
1.85
1.34
2.2
1.9
—
—
—
0
0
49
365
1.41
1.33
1.1
1.3
4.74
8.57
u/ml
0.44
23
142
15
250
0.58
1.26
2.5
1.9
—
—
—
0
0
6
25
2.43
1.25
1.0
1.5
—
—
—
0
0
21
132
1.64
1.24
1.4
1.8
—
—
—
0
0
11
56
2.00
1.23
1.3
1.4
—
—
—
0
0
117
1005
1.27
1.21
2.9
2.9
114.56
112.52
ug/l
0.04
109
921
8
39
2.08
1.16
1.1
1.2
—
1.17
—
0
12
12
66
1.85
1.10
1.4
1.7
—
—
—
0
0
10
52
1.96
1.07
1.5
1.2
—
—
—
0
0
240
2266
1.33
1.07
4.4
4.3
5.83
5.92
mmol/l
0.51
222
2072
12
67
1.82
1.06
1.5
1.2
—
—
—
0
0
37
274
1.40
1.06
1.6
1.8
—
—
—
0
0
10
53
1.92
1.02
1.7
1.4
—
—
—
0
0
10
53
1.92
1.02
1.7
1.4
—
—
—
0
0
57
455
1.31
1.02
1.6
1.7
392.09
444.72
pmol/l
0.89
47
383
268
2580
1.45
1.00
10.4
10.4
50.53
27.00
u/l
4.54
263
2487
5
23
2.19
0.98
1.2
2.6
13.80
13.31
%
—
5
23
0
29
0.00
0.98
0.0
1.3
—
—
—
0
0
37
279
1.37
0.96
1.6
1.8
—
—
—
0
0
62
507
1.28
0.93
4.6
3.7
1.02
1.02
kg/l
0.03
12
65
24
169
1.46
0.91
2.3
3.8
1.23
1.23
mmol/l
0.08
19
152
63
522
1.26
0.86
2.2
2.5
2.57
1.30
mg/l
0.35
45
408
8
48
1.69
0.79
1.8
1.5
5734.75
8557.03
e6/l
—
8
35
14
209
0.65
0.79
1.2
1.8
—
—
—
0
0
25
185
1.38
0.75
2.0
2.7
137.40
66.36
ml/min/173m2
—
10
72
5
25
2.02
0.73
1.6
1.9
—
—
—
0
0
5
25
2.02
0.73
1.6
1.9
—
—
—
0
0
5
25
2.02
0.73
1.6
1.9
—
—
—
0
0
9
57
1.60
0.72
1.0
1.4
—
—
—
0
0
62
525
1.23
0.71
1.4
1.6
19.85
21.22
nmol/l
0.31
51
434
13
86
1.54
0.67
1.2
1.2
—
—
—
0
0
19
137
1.41
0.66
1.4
1.3
—
—
—
0
0
97
864
1.18
0.66
4.3
3.6
—
—
—
0
0
13
87
1.52
0.64
1.2
1.2
—
—
—
0
0
5
29
1.74
0.64
1.2
1.3
—
—
—
0
0
172
1610
1.17
0.62
3.0
3.5
41.76
47.62
u/l
0.50
158
1512
5
30
1.68
0.61
3.0
3.7
—
—
—
0
0
0
21
0.00
0.60
0.0
1.5
—
—
—
0
0
35
284
1.26
0.59
4.6
4.5
29.86
31.58
%
0.49
28
186
0
23
0.00
0.58
0.0
1.1
—
—
—
0
0
11
73
1.53
0.57
2.6
2.4
—
—
—
0
0
29
231
1.28
0.56
2.1
4.3
28.82
26.01
ug/l
0.04
21
193
6
38
1.59
0.54
1.0
1.2
11.08
14.58
u/l
—
6
33
16
117
1.39
0.53
2.1
1.6
19.97
24.24
iu/l
—
9
96
61
694
0.85
0.52
3.4
3.8
5.88
9.82
mg/mmol
0.73
40
442
6
40
1.51
0.52
1.2
1.1
—
—
—
0
0
11
75
1.48
0.51
1.6
1.4
—
—
—
0
0
82
735
1.16
0.51
2.4
2.7
56.45
62.68
u/l
0.43
75
678
277
2720
1.34
0.48
23.3
20.1
40.24
40.42
%
0.19
267
2568
7
47
1.50
0.48
1.4
1.2
—
—
—
0
0
7
47
1.50
0.48
1.1
1.7
—
—
—
0
0
10
69
1.47
0.45
1.6
1.7
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
5
31
1.62
0.43
1.0
1.8
—
—
—
0
0
35
297
1.20
0.42
1.8
4.1
6.32
8.26
umol/l
0.56
28
265
5
33
1.52
0.41
1.0
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
243.09
—
0
16
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
2.8
—
—
—
0
0
5
34
1.48
0.40
1.0
1.6
—
—
—
0
0
5
34
1.48
0.40
1.0
1.6
—
—
—
0
0
5
34
1.48
0.40
1.0
1.6
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
5
35
1.44
0.39
1.0
1.5
—
—
—
0
0
5
35
1.44
0.39
1.0
1.5
—
—
—
0
0
9
66
1.38
0.38
1.0
1.2
—
—
—
0
0
21
170
1.25
0.38
1.5
1.5
—
—
—
0
0
5
36
1.40
0.38
1.2
1.7
—
—
—
0
0
19
153
1.26
0.36
1.2
1.3
—
—
—
0
0
42
369
1.16
0.35
2.8
3.1
29.99
29.72
s
0.12
42
361
6
46
1.31
0.33
2.0
3.2
18.83
20.49
u/ml
—
6
46
33
286
1.17
0.33
6.0
7.1
—
—
—
0
0
7
57
1.23
0.29
1.4
1.9
—
—
—
0
0
7
57
1.23
0.29
1.4
1.9
—
—
—
0
0
27
234
1.17
0.27
3.4
3.1
—
—
—
0
0
66
610
1.11
0.27
4.3
3.8
0.00
0.01
estimate
0.50
20
207
171
1651
1.09
0.26
2.7
3.1
—
—
—
0
0
228
2231
1.10
0.25
4.0
4.0
1.37
1.29
mmol/l
0.87
218
2053
66
614
1.10
0.24
1.3
1.4
0.67
1.86
u/ml
1.85
18
159
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
85.00
—
0
13
0
13
0.00
0.21
0.0
1.5
—
7.20
—
0
13
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
56
523
1.09
0.19
5.1
4.1
20.58
21.93
%
0.29
26
240
13
153
0.84
0.18
1.2
1.0
—
—
—
0
0
7
62
1.13
0.17
1.4
1.5
—
—
—
0
0
12
101
1.20
0.17
1.8
1.6
—
—
—
0
0
235
2316
1.07
0.16
4.5
4.4
4.80
4.66
mmol/l
1.24
225
2156
234
2306
1.07
0.16
4.3
4.4
1.48
1.46
mmol/l
0.18
224
2129
9
79
1.14
0.15
1.1
1.3
—
—
—
0
0
239
2360
1.07
0.14
4.7
4.8
2.92
2.78
mmol/l
1.45
228
2175
8
98
0.81
0.14
1.4
2.0
—
—
—
0
0
36
385
0.93
0.13
3.4
2.8
0.67
0.74
ug/l
0.26
25
250
67
643
1.05
0.11
1.7
1.7
1.51
1.39
mmol/l
0.65
60
547
56
585
0.95
0.10
2.4
3.3
348.80
7683.69
umol/l
2.64
50
510
52
497
1.06
0.10
1.5
1.6
—
—
—
0
0
41
391
1.06
0.08
1.2
1.3
18.01
32.92
iu/ml
1.21
11
126
6
70
0.85
0.07
1.0
1.1
—
11.52
—
0
9
8
74
1.08
0.07
1.4
1.8
—
—
—
0
0
10
90
1.12
0.05
1.0
1.1
—
—
—
0
0
10
91
1.10
0.04
1.1
2.6
—
—
—
0
0
67
660
1.02
0.02
5.4
4.5
2.12
2.17
ug/l
0.04
60
592
10
95
1.05
0.00
1.3
1.9
—
—
—
0
0
32
316
1.01
0.00
1.5
1.5
—
—
—
0
0
7
72
0.97
-0.00
1.1
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
7.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
52.68
—
0
9
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
12
120
1.00
-0.00
1.4
1.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
7.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
64
0.94
-0.00
1.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
7.3
—
—
—
0
0
7
70
1.00
-0.00
1.3
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
9.63
—
0
9
0
7
0.00
-0.00
0.0
8.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
54
0.92
-0.00
3.6
6.9
—
3362.50
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
7.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_MUSDYST and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MUSDYST | 2.114 [1.67, 2.68] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.093 |
During the follow-up period (1.1.1998 — 31.12.2019), 115 out of 684 females with G6_MUSDYST died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MUSDYST | 1.948 [1.55, 2.44] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.019 |
During the follow-up period (1.1.1998 — 31.12.2019), 174 out of 857 males with G6_MUSDYST died.
Mortality risk
Mortality risk for people of age
years, who have G6_MUSDYST.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.191% | 0.467% |
| 5 | 1.208% | 2.381% |
| 10 | 3.093% | 5.877% |
| 15 | 5.646% | 10.977% |
| 20 | 9.656% | 18.189% |
Relationships between endpoints
↥Index endpoint: G6_MUSDYST – Muscular dystrophy
GWS hits: 22
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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