retinal detachment: An eye emergency condition which may lead to blindness if left untreated. It is characterized by the separation of the inner retina layers from the underlying pigment epithelium. Causes include trauma, advanced diabetes mellitus, high myopia, and choroid tumors. Symptoms include sudden appearance of floaters, sudden light flushes, and blurred vision.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
304 |
4. Check minimum number of eventsNone |
304 |
5. Include endpointsNone |
304 |
6. Filter based on genotype QC (FinnGen only) |
304 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H33
- Name in latin
- Ablatio retinae e tractione
Similar endpoints
↥List of similar endpoints to
Traction detachment of retina
based on the number of shared cases.
Similar with more cases:
- Retinal detachments and breaks
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2013 | 939 | 1062 |
| Only index persons | 1790 | 849 | 941 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 59.71 | 61.10 | 58.39 |
| Only index persons | 58.66 | 59.96 | 57.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 304 | 138 | 166 |
| Unadjusted period prevalence (%) | 0.06 | 0.05 | 0.07 |
| Median age at first event (years) | 54.02 | 51.46 | 56.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 281
- Matched controls
- 2810
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
323.0
279
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
+∞
165.5
142
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
683.5
129.1
118
*
CKD40
NOMESCO Finland
Endophotocoagulation of retina
+∞
114.6
102
*
H3603, E103
ICD-10 Finland
NA
+∞
113.4
101
*
H43.1
ICD-10 Finland
Vitreous haemorrhage
204.8
105.6
104
8
CKC12
NOMESCO Finland
Photocoagulation of retina
362.2
100.9
96
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
237.7
97.2
95
6
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
84.3
97.1
106
20
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
149.3
96.4
98
10
A10AA02
ATC
NA
65.2
91.2
104
25
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
+∞
90.6
82
*
A10AA01
ATC
NA
93.3
87.3
94
15
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
67.6
86.6
98
22
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
26.3
85.8
125
83
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
14.5
85.6
222
580
CKD20
NOMESCO Finland
Removal of vitreous body substitute
+∞
84.8
77
*
WX140
NOMESCO Finland
Parabulbar anesthesy
81.0
84.6
93
17
T89
ICPC
Diabetes insulin dependent
99.3
83.3
89
13
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
1032.1
81.7
76
*
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
+∞
80.1
73
*
A10AE04
ATC
insulin glargine; parenteral
21.1
78.5
124
101
CKD15
NOMESCO Finland
Injection of vitreous substitute
+∞
77.8
71
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
27.6
75.8
107
61
CKC10
NOMESCO Finland
Local photocoagulation of retina
309.0
71.9
70
*
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
+∞
70.9
65
*
S01ED51
ATC
timolol, combinations; ophthalmic
21.2
69.6
108
80
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
90.8
63.6
69
10
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
51.4
61.3
73
19
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
21.6
56.8
86
56
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
661.4
56.7
54
*
H04AA01
ATC
glucagon; nasal, parenteral
79.0
56.1
62
10
Z96.1
ICD-10 Finland
Presence of intraocular lens
12.1
55.3
112
146
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
8.0
54.9
168
440
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
+∞
53.9
50
*
XCK10
NOMESCO Finland
Photography of fundus of eye
14.3
53.9
98
101
CKC15
NOMESCO Finland
Panretinal photocoagulation
+∞
50.6
47
*
H3603, E113
ICD-10 Finland
NA
+∞
49.5
46
*
103
Kela drug reimbursment
Diabetes, insulin-treated
7.2
49.3
162
449
215
Kela drug reimbursment
Diabetes, non-insulin-treated
7.4
48.4
147
362
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
187.2
46.4
47
*
A10AE05
ATC
insulin detemir; parenteral
16.4
45.4
76
62
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
+∞
42.8
40
*
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
473.8
42.3
41
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
106.8
42.2
45
5
Z01.0
ICD-10 Finland
Examination of eyes and vision
7.5
41.6
115
237
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
20.0
41.1
63
40
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
40.2
40.1
50
15
XCW99
NOMESCO Finland
Other investigative procedure of eye
10.3
39.4
84
112
H36.01
ICD-10 Finland
Diabetic maculopathy
+∞
38.4
36
*
CKC70
NOMESCO Finland
Circular buckling of sclera
+∞
38.4
36
*
H3601, E103
ICD-10 Finland
NA
+∞
37.3
35
*
H26.2
ICD-10 Finland
Complicated cataract
77.3
36.0
40
6
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
393.8
35.8
35
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
137.0
34.6
36
*
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
40.8
33.9
42
12
S01ED01
ATC
timolol; ophthalmic
16.0
33.2
55
42
CKC60
NOMESCO Finland
Local buckling of sclera using implant
+∞
33.0
31
*
H33.3
ICD-10 Finland
Retinal breaks without detachment
+∞
33.0
31
*
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
363.0
32.6
32
*
S01EC01
ATC
acetazolamide; systemic
25.2
32.1
45
21
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
96.4
31.5
34
*
H26.4
ICD-10 Finland
After-cataract
9.8
31.0
66
85
H3600, E103
ICD-10 Finland
NA
+∞
30.8
29
*
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
93.2
30.5
33
*
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
24.3
28.3
40
19
A10AE06
ATC
insulin degludec; parenteral
25.6
27.4
38
17
SPAT1262
SPAT
Handing over of treatment supplies
5.2
27.0
99
268
S01BC05
ATC
ketorolac; ophthalmic
12.9
26.6
48
44
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
+∞
26.5
25
*
A10AA03
ATC
NA
80.3
26.3
29
*
E10
ICD-10 Finland
Type 1 diabetes mellitus
35.9
25.2
32
10
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
142.7
25.0
26
*
ZXA00
NOMESCO Finland
Right side
4.2
24.8
119
416
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
+∞
24.3
23
*
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
136.7
24.0
25
*
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
10.3
23.8
48
55
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
27.6
23.7
32
13
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
+∞
23.2
22
*
H36.00
ICD-10 Finland
Diabetic background retinopathy
249.5
23.0
23
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
8.3
22.5
52
75
CKC30
NOMESCO Finland
Cryopexy of detached retina
+∞
22.2
21
*
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
87.3
22.0
24
*
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
237.7
21.9
22
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
19.6
20.1
30
17
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
19.6
20.1
30
17
S01EA03
ATC
apraclonidine; ophthalmic
31.6
20.0
26
9
H25.1
ICD-10 Finland
Senile nuclear cataract
3.9
19.9
101
356
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
113.1
19.8
21
*
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
43.6
19.8
24
6
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.3
19.8
141
651
H33.5
ICD-10 Finland
Other retinal detachments
214.5
19.8
20
*
A11CC03
ATC
alfacalcidol; systemic
22.0
19.5
28
14
ZXA05
NOMESCO Finland
Left side
3.5
18.5
108
424
Z94.0
ICD-10 Finland
Kidney transplant status
35.6
18.3
23
7
NHQ40
NOMESCO Finland
Amputation of toe
24.8
18.1
25
11
H26.02
ICD-10 Finland
Presenil cataract
17.4
17.4
27
17
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
10.3
17.2
34
37
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
53.6
17.2
20
*
H35.6
ICD-10 Finland
Retinal haemorrhage
+∞
16.8
16
*
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
180.3
16.7
17
*
114
Kela drug reimbursment
Glaucoma
5.4
16.3
51
110
127
Kela drug reimbursment
Transplant complication
26.4
16.3
22
9
S01EE01
ATC
latanoprost; ophthalmic
6.7
16.1
42
72
CKD95
NOMESCO Finland
Extended combined vitectomy and lens procedure through pars plana
169.0
15.6
16
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
40.6
15.6
19
5
177
Kela drug reimbursment
Insulin glargine 300 U / ml
19.1
15.4
23
13
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
+∞
14.7
14
*
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
157.9
14.6
15
*
L04AA06
ATC
mycophenolic acid; systemic
18.2
14.6
22
13
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
45.0
14.3
17
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
4.8
14.1
49
118
Z49.1
ICD-10 Finland
Extracorporeal dialysis
21.4
14.0
20
10
C03CA01
ATC
furosemide; systemic
2.9
13.9
105
477
H34.8
ICD-10 Finland
Other retinal vascular occlusions
+∞
13.6
13
*
H3601, E113
ICD-10 Finland
NA
+∞
13.6
13
*
H28.0*E10.3
ICD-10 Finland
Other specified diabetes mellitus - Diabetic cataract
146.8
13.6
14
*
WX142
NOMESCO Finland
Sub-tenon anesthesy
146.8
13.6
14
*
XCH00
NOMESCO Finland
Eye pressure measurement
7.8
13.5
31
44
B03XA02
ATC
darbepoetin alfa; parenteral
17.8
13.2
20
12
WX002
NOMESCO Finland
Sedation and analgesia
3.2
13.1
79
306
C10AA01
ATC
simvastatin; oral
2.6
12.8
136
748
CKD50
NOMESCO Finland
Endodiathermy of retina
+∞
12.6
12
*
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
+∞
12.6
12
*
H3602, E103
ICD-10 Finland
NA
+∞
12.6
12
*
TK800
NOMESCO Finland
Hemodialysis
10.4
12.5
24
25
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.8
12.4
57
178
C09AA02
ATC
enalapril; systemic
3.1
12.2
78
312
A12AA04
ATC
calcium carbonate; oral
22.5
12.2
17
8
I10
ICD-10 Finland
Essential (primary) hypertension
2.5
12.0
175
1122
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
24.1
11.7
16
7
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
67.9
11.7
13
*
CKC20
NOMESCO Finland
Cryopexy of undetached retina
124.9
11.5
12
*
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
36.7
11.4
14
*
S01EC03
ATC
dorzolamide; ophthalmic
18.0
11.3
17
10
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
21.1
11.3
16
8
N18.0
ICD-10 Finland
End-stage renal disease
21.1
11.3
16
8
S01BC03
ATC
diclofenac; ophthalmic
11.9
11.2
20
18
S01FA04
ATC
cyclopentolate; ophthalmic
14.7
11.1
18
13
S01EC04
ATC
brinzolamide; ophthalmic
7.7
11.0
25
35
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.7
10.8
31
60
T90
ICPC
Diabetes non-insulin dependent
2.8
10.8
81
355
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
4.2
10.5
41
111
H35.4
ICD-10 Finland
Peripheral retinal degeneration
+∞
10.5
10
*
H3600, E113
ICD-10 Finland
NA
+∞
10.5
10
*
H33.2
ICD-10 Finland
Serous retinal detachment
+∞
10.5
10
*
H54.0
ICD-10 Finland
Blindness, binocular
+∞
10.5
10
*
25002
ICD-8 Finland
Diabetes mellitus, Retinopathia diabetica
+∞
10.5
10
*
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
24.4
10.3
14
6
XCD10
NOMESCO Finland
Electrophysiological examination of eye
10.6
10.2
19
19
H40.0
ICD-10 Finland
Glaucoma suspect
4.8
10.0
33
75
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
12.8
10.0
17
14
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
27.1
9.9
13
5
C10AA05
ATC
atorvastatin; oral
2.3
9.7
114
637
S01EE05
ATC
tafluprost; ophthalmic
8.0
9.6
21
28
Z49.0
ICD-10 Finland
Preparatory care for dialysis
18.3
9.5
14
8
ZX198
NOMESCO Finland
Other local administration
31.2
9.5
12
*
3643
FHL
Vitrectomy through pars Plana
+∞
9.4
9
*
2504B
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYYPPI I]
+∞
9.4
9
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
5.7
9.3
26
49
C07AB07
ATC
bisoprolol; oral
2.2
9.3
138
853
C08CA01
ATC
amlodipine; oral
2.3
9.3
112
629
H16.0
ICD-10 Finland
Corneal ulcer
6.3
9.3
24
41
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
14.3
9.3
15
11
S01EE03
ATC
bimatoprost; ophthalmic
7.9
9.1
20
27
S01EX03
ATC
NA
8.4
9.0
19
24
205
Kela drug reimbursment
Chronic hypertension
2.4
8.9
92
476
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.5
8.9
84
413
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
5.9
8.8
24
44
H25.8
ICD-10 Finland
Other senile cataract
3.5
8.7
41
130
137
Kela drug reimbursment
Uraemia requiring dialysis
51.6
8.7
10
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.5
8.7
30
72
S18
ICPC
Laceration/cut
2.2
8.7
120
713
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
16.9
8.6
13
8
S01EC54
ATC
brinzolamide, combinations; ophthalmic
16.9
8.6
13
8
B05DB
ATC
Hypertonic solutions
92.7
8.5
9
*
B05DA
ATC
Isotonic solutions
92.7
8.5
9
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
92.7
8.5
9
*
H36.02
ICD-10 Finland
Preproliferative diabetic retinopathy
+∞
8.4
8
*
25008
ICD-8 Finland
Diabetes mellitus, Complicatio alia definita
+∞
8.4
8
*
3620B
ICD-9 Finland
Other retinal disorders, Diabetic retinopathy[RETINOPATHIA DIABETICA PROLIFERATIVA]
+∞
8.4
8
*
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
+∞
8.4
8
*
H54.4
ICD-10 Finland
Blindness, monocular
+∞
8.4
8
*
H35.29
ICD-10 Finland
Other proliferative retinopathy
+∞
8.4
8
*
XCK00
NOMESCO Finland
Perimetry
4.1
8.3
32
86
C02AC05
ATC
moxonidine; oral
4.9
8.2
26
57
L84
ICD-10 Finland
Corns and callosities
6.2
8.2
21
36
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
6.0
8.0
21
37
H20.1
ICD-10 Finland
Chronic iridocyclitis
13.6
8.0
13
10
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
15.6
7.8
12
8
S97
ICPC
Chronic ulcer skin
4.6
7.8
26
61
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
46.3
7.8
9
*
V03AE02
ATC
sevelamer; oral
46.3
7.8
9
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.9
7.7
31
87
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
19.0
7.7
11
6
A46
ICD-10 Finland
Erysipelas
2.8
7.6
53
217
J01FF01
ATC
clindamycin; systemic
2.2
7.6
88
475
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
25.8
7.6
10
*
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
82.2
7.5
8
*
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
7.2
7.4
17
25
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.0
7.3
28
75
H21.0
ICD-10 Finland
Hyphaema
+∞
7.3
7
*
H3603, E107
ICD-10 Finland
NA
+∞
7.3
7
*
H54.1
ICD-10 Finland
Severe visual impairment, binocular
+∞
7.3
7
*
H35.37
ICD-10 Finland
Macular holes
+∞
7.3
7
*
V03AE01
ATC
polystyrene sulfonate; oral
10.4
7.1
13
13
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
3.3
7.1
35
116
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
6.2
6.7
17
29
CA1ME
NOMESCO Finland
Ultrasound oculometry
23.2
6.7
9
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.1
6.7
25
66
S01EE04
ATC
travoprost; ophthalmic
8.5
6.4
13
16
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
11.4
6.3
11
10
H27.0
ICD-10 Finland
Aphakia
18.5
6.3
9
5
CKD45
NOMESCO Finland
Endocryotherapy of retina
+∞
6.3
6
*
H3603, E109
ICD-10 Finland
NA
+∞
6.3
6
*
CKC65
NOMESCO Finland
Removal of buckling implant from sclera
+∞
6.3
6
*
M14.6*E10.6
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic neuropathic
+∞
6.3
6
*
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
27.3
6.3
8
*
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
27.3
6.3
8
*
A28
ICPC
Limited function/disability NOS
2.6
6.2
46
198
H53.1
ICD-10 Finland
Subjective visual disturbances
4.0
6.2
23
61
A10AB06
ATC
insulin glulisine; parenteral
12.9
6.1
10
8
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
7.0
6.1
14
21
A10AD05
ATC
insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
10.3
6.1
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
162
676
3.99
31.63
8.7
3.8
40.2
8.7
mg/mmol
3.63
136
438
58
154
4.42
20.41
10.6
3.6
230.1
83.3
ng/l
4.00
52
133
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
30
64
5.09
13.62
5.0
2.7
0.4
0.4
u/ml
0.36
15
36
29
64
4.90
12.65
4.1
2.0
635.0
73.0
ug/min
1.23
19
34
21
35
6.37
12.30
21.5
7.0
466.7
286.1
iu/ml
—
10
7
11
0
+∞
11.53
6.2
0.0
—
—
—
0
0
70
300
2.73
11.21
7.1
2.3
23.3
22.2
%
0.25
64
256
21
41
5.43
10.47
2.5
1.2
—
—
—
0
0
52
199
2.95
10.23
15.2
3.9
0.5
2.0
mmol/l
2.69
44
156
13
16
8.44
9.81
1.4
1.2
—
—
—
0
0
21
45
4.94
9.44
1.9
1.2
212.3
262.4
u/ml
0.31
16
25
41
150
3.00
8.70
6.3
3.0
1.4
1.7
mmol/l
0.15
30
102
11
5
22.74
8.07
1.1
1.0
—
—
—
0
0
20
47
4.48
8.07
1.9
1.2
—
—
—
0
0
16
31
5.39
8.02
1.4
1.1
—
—
—
0
0
41
158
2.84
7.92
6.4
3.0
5.1
5.1
kpa
0.24
41
146
114
693
2.03
7.78
2.7
2.1
157.0
228.7
u/l
1.32
108
656
32
111
3.10
7.42
2.7
2.3
1.7
1.4
g/l
0.81
32
94
97
571
2.03
7.13
2.6
2.0
3.4
3.1
mg/l
0.49
87
495
12
20
6.21
6.96
2.8
3.4
—
—
—
0
0
136
918
1.87
6.56
3.3
2.3
67.9
75.5
nmol/l
3.24
122
820
89
528
1.97
6.30
1.5
1.2
2.6
1.4
u/ml
0.33
32
146
186
1400
1.85
6.19
14.0
4.4
9.4
6.7
mmol/l
15.19
178
1303
104
662
1.87
5.90
3.0
3.2
3344.0
1334.4
ng/l
1.80
93
547
53
267
2.19
5.77
10.6
7.0
0.1
1.1
mmol/l
0.89
42
205
155
1123
1.78
5.68
24.5
6.3
1.2
1.2
mmol/l
0.40
140
954
49
245
2.19
5.43
3.9
3.3
—
—
—
0
0
25
91
2.90
5.35
2.5
2.2
318.6
308.7
ug/l
0.02
25
86
67
382
1.97
5.23
2.6
1.8
—
—
—
0
0
131
926
1.73
5.07
2.1
1.9
106.2
96.9
pmol/l
1.13
76
486
141
1018
1.72
5.05
21.1
5.5
1.2
1.2
mmol/l
1.02
131
932
137
982
1.72
5.03
11.3
4.5
33.1
35.8
g/l
6.20
130
923
48
246
2.13
4.99
1.9
1.6
—
—
—
0
0
95
619
1.78
4.85
5.1
2.7
4538.3
7268.0
umol/l
0.25
78
535
38
179
2.28
4.85
3.7
2.6
47.9
68.3
ml/min/173m2
1.57
19
77
137
1005
1.66
4.47
5.4
2.7
189.2
130.4
ug/l
1.48
129
926
89
583
1.74
4.41
4.4
2.2
—
—
—
0
0
78
492
1.79
4.40
1.7
1.8
210769658.0
444.2
pmol/l
0.49
65
422
251
2170
1.90
4.37
14.3
5.5
53.4
39.6
mmol/mol
24.97
235
2034
107
752
1.65
4.04
8.3
2.5
54.3
56.5
u/l
0.23
101
705
24
103
2.44
3.77
2.5
2.1
—
—
—
0
0
184
1492
1.59
3.75
8.0
4.3
10.4
3370.8
e6/l
—
7
21
87
590
1.66
3.73
2.1
1.6
1.3
1.4
mmol/l
0.36
75
501
103
734
1.61
3.61
5.2
3.3
2.3
2.3
mmol/l
0.14
87
649
242
2114
1.71
3.50
6.0
4.6
2.0
1.9
mu/l
1.33
223
1934
65
416
1.72
3.43
1.8
1.7
1514.3
1209.1
nmol/l
1.48
53
315
269
2434
1.91
3.30
36.7
15.6
4.1
4.0
mmol/l
4.91
264
2364
81
556
1.62
3.27
1.7
1.5
19.8
21.0
nmol/l
0.36
73
468
10
28
3.66
3.22
1.2
1.2
—
—
—
0
0
8
15
5.45
3.21
1.3
1.4
—
—
—
0
0
48
287
1.80
3.20
23.9
22.9
1.7
1.3
inr
—
6
44
27
132
2.15
3.18
2.0
1.7
—
—
—
0
0
16
62
2.67
3.09
1.7
1.5
—
—
—
0
0
43
251
1.83
3.09
2.0
1.7
—
—
—
0
0
203
1722
1.54
3.09
5.8
4.0
17.5
11.7
mm/h
4.54
184
1588
21
94
2.33
3.04
2.5
1.9
—
—
—
0
0
108
805
1.53
3.03
4.0
3.1
32.4
32.4
u/l
0.00
101
763
16
63
2.63
3.01
1.8
1.8
—
—
—
0
0
7
13
5.48
2.88
7.0
2.7
—
—
—
0
0
210
1818
1.50
2.71
12.9
7.4
87.5
77.3
u/l
2.44
202
1706
17
74
2.37
2.63
1.3
1.2
—
—
—
0
0
251
2265
1.62
2.62
6.1
3.8
1.3
1.3
mmol/l
0.45
233
2097
7
16
4.45
2.49
1.3
1.4
—
—
—
0
0
7
16
4.45
2.49
1.3
1.4
—
—
—
0
0
12
45
2.74
2.48
2.6
2.4
16.5
15.4
%
—
6
23
71
504
1.53
2.44
5.6
3.8
1.0
1.0
kg/l
0.78
11
63
16
71
2.32
2.38
1.5
3.7
51.0
30.5
mg/l
0.86
11
55
16
71
2.32
2.38
1.5
3.7
79.0
160.9
mg/l
0.41
11
55
150
1237
1.42
2.37
8.0
6.3
10.1
11.6
umol/l
1.76
143
1179
18
85
2.19
2.34
1.1
2.2
—
—
—
0
0
8
24
3.39
2.19
1.1
1.4
—
—
—
0
0
14
61
2.36
2.18
1.5
1.6
—
—
—
0
0
106
832
1.42
2.17
8.5
3.0
—
—
—
0
0
19
95
2.07
2.16
9.6
3.5
24.0
25.0
mmol/l
0.64
19
90
29
169
1.79
2.13
2.1
1.6
—
—
—
0
0
10
37
2.76
2.12
1.8
1.6
—
—
—
0
0
8
25
3.26
2.11
1.3
1.4
—
—
—
0
0
6
15
4.06
2.05
1.3
1.3
—
—
—
0
0
6
15
4.06
2.05
1.3
1.3
—
—
—
0
0
14
63
2.28
2.04
1.1
2.5
0.0
0.0
g/l
0.00
14
63
115
924
1.39
2.04
5.3
3.7
70.7
41.7
ng/l
0.67
89
629
10
38
2.69
2.03
1.8
1.6
—
—
—
0
0
10
38
2.69
2.03
1.8
1.6
—
—
—
0
0
10
38
2.69
2.03
1.8
1.6
—
—
—
0
0
245
2238
1.49
2.01
26.8
12.7
74.4
82.6
ml/min/173m2
4.76
213
1844
13
57
2.34
2.00
1.4
1.6
—
—
—
0
0
5
11
4.60
1.95
1.2
1.4
—
—
—
0
0
10
39
2.62
1.94
1.8
1.6
—
—
—
0
0
10
39
2.62
1.94
1.8
1.6
—
—
—
0
0
9
34
2.70
1.88
1.3
1.4
—
—
—
0
0
20
110
1.88
1.77
15.3
2.7
1.5
1.3
%
0.21
20
110
252
2337
1.46
1.69
7.0
4.2
1.4
1.4
mmol/l
0.40
233
2166
10
42
2.43
1.69
1.5
1.4
—
—
—
0
0
10
42
2.43
1.69
1.5
1.4
—
—
—
0
0
135
1139
1.33
1.68
5.4
3.4
0.0
0.0
estimate
0.00
22
220
80
624
1.38
1.65
6.4
3.7
0.0
0.0
estimate
0.00
20
216
5
14
3.61
1.62
1.2
1.4
—
—
—
0
0
135
1145
1.32
1.61
6.9
4.6
0.0
0.0
estimate
0.00
22
224
50
361
1.46
1.58
6.1
2.7
3.7
2.3
e6/l
0.52
33
188
57
423
1.43
1.56
4.6
3.6
98.1
143.1
ng/l
0.34
49
324
39
269
1.52
1.54
12.4
8.1
—
—
—
0
0
15
79
1.95
1.52
2.7
1.2
—
—
—
0
0
252
2350
1.42
1.52
6.9
4.2
4.2
4.6
mmol/l
7.29
232
2191
6
21
2.89
1.51
1.0
1.0
—
—
—
0
0
12
58
2.11
1.51
1.1
2.6
0.0
0.0
g/l
0.00
12
58
12
58
2.11
1.51
1.1
2.6
0.0
0.0
g/l
0.00
12
58
256
2395
1.44
1.50
7.4
4.6
2.3
2.8
mmol/l
13.40
239
2215
9
38
2.41
1.47
1.6
2.1
—
—
—
0
0
135
1158
1.30
1.44
5.4
3.5
0.0
0.0
estimate
0.50
19
212
13
232
0.54
1.37
1.7
1.7
—
—
—
0
0
81
652
1.33
1.36
6.4
2.8
0.3
0.4
e6/l
0.01
62
480
9
42
2.18
1.35
1.3
1.5
—
—
—
0
0
158
1396
1.27
1.30
9.9
9.4
4.7
4.1
e9/l
2.08
136
1228
190
1718
1.28
1.29
4.8
3.8
15.0
14.8
pmol/l
0.71
173
1569
5
18
2.81
1.29
1.0
1.1
—
—
—
0
0
5
18
2.81
1.29
1.0
1.1
—
—
—
0
0
39
281
1.44
1.26
6.8
4.3
35.9
32.0
%
1.59
31
192
129
1115
1.27
1.26
6.0
4.1
—
—
—
0
0
6
26
2.33
1.19
1.2
1.3
—
—
—
0
0
64
508
1.33
1.18
1.7
1.9
1.3
1.2
mg/l
0.06
49
392
5
20
2.52
1.15
1.0
1.4
—
—
—
0
0
12
65
1.88
1.15
1.2
1.3
—
302.7
—
0
31
0
36
0.00
1.14
0.0
1.1
—
—
—
0
0
7
30
2.36
1.13
1.1
1.8
—
—
—
0
0
253
2392
1.34
1.13
29.5
13.8
23.1
23.4
mg/l
0.06
212
1880
20
300
0.64
1.10
1.5
1.4
—
—
—
0
0
21
310
0.65
1.08
1.9
2.1
—
—
—
0
0
9
46
1.99
1.04
1.3
1.6
—
—
—
0
0
50
391
1.33
1.03
6.1
2.5
0.7
0.9
e6/l
0.48
33
216
7
133
0.52
1.01
1.3
1.5
—
—
—
0
0
5
23
2.19
0.98
1.2
1.3
205.6
283.1
u/l
—
5
23
0
29
0.00
0.98
0.0
1.0
—
—
—
0
0
13
78
1.70
0.93
2.2
2.4
189.2
3774.0
u/l
—
5
33
10
56
1.81
0.89
1.6
1.4
—
—
—
0
0
26
188
1.42
0.86
7.5
3.8
1.2
1.2
mmol/l
0.77
26
171
19
269
0.69
0.82
1.6
1.9
—
—
—
0
0
11
66
1.69
0.79
1.7
1.5
—
—
—
0
0
11
66
1.69
0.79
1.3
1.1
—
16.3
—
0
6
37
292
1.30
0.74
2.2
2.4
6.2
9.5
umol/l
1.46
32
252
5
26
1.94
0.71
1.0
1.9
—
—
—
0
0
176
1641
1.17
0.67
3.5
3.0
49.4
49.1
u/l
0.01
164
1540
19
137
1.41
0.66
1.7
1.4
—
—
—
0
0
210
2204
0.85
0.64
27.6
14.5
37.1
40.5
%
5.53
144
1626
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
263
2551
1.23
0.57
16.9
10.0
24.6
27.1
u/l
1.74
255
2464
8
124
0.64
0.56
1.1
1.0
—
—
—
0
0
9
62
1.47
0.53
1.4
1.1
12.6
13.6
e6/l
—
9
47
9
62
1.47
0.53
1.8
1.2
46.0
188.8
e6/l
—
9
48
6
39
1.55
0.53
1.2
1.1
—
—
—
0
0
12
83
1.46
0.52
1.1
1.6
—
—
—
0
0
6
40
1.51
0.52
1.0
1.6
—
—
—
0
0
99
901
1.15
0.50
5.8
3.6
—
—
—
0
0
64
722
0.86
0.49
4.4
4.0
24.0
21.4
%
0.55
28
320
7
50
1.41
0.45
1.3
1.6
—
—
—
0
0
7
51
1.38
0.44
1.1
1.3
—
—
—
0
0
8
59
1.37
0.41
1.4
1.2
4.5
3.7
mmol/l
—
8
53
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
5
34
1.48
0.40
1.2
1.2
—
—
—
0
0
9
66
1.37
0.38
1.9
1.7
—
—
—
0
0
10
136
0.73
0.38
1.0
1.2
—
—
—
0
0
6
41
1.47
0.36
1.3
1.3
21.0
12.0
u/l
—
6
35
8
66
1.22
0.27
1.5
1.2
577.4
444.7
mg/l
—
8
61
38
424
0.88
0.27
1.6
1.5
—
—
—
0
0
48
522
0.90
0.23
3.0
2.8
0.7
0.7
ug/l
0.34
37
317
158
1527
1.07
0.22
3.0
3.1
—
—
—
0
0
5
41
1.22
0.22
1.4
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
8.3
—
0
11
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
8.9
—
34.3
—
0
6
7
59
1.19
0.18
1.1
1.3
—
—
—
0
0
231
2277
1.06
0.14
6.2
4.4
8.0
5.9
mmol/l
12.37
206
2096
5
48
1.04
0.09
2.0
1.4
—
—
—
0
0
8
78
1.03
0.07
3.5
2.8
—
—
—
0
0
7
84
0.83
0.07
1.0
1.1
—
—
—
0
0
89
911
0.97
0.07
4.8
4.5
2.1
2.0
ug/l
0.10
79
818
7
85
0.82
0.07
1.0
1.1
—
—
—
0
0
9
84
1.07
0.07
1.4
1.6
—
—
—
0
0
35
365
0.95
0.06
1.2
1.3
6.2
9.7
u/ml
—
10
155
38
370
1.03
0.03
1.1
1.3
12.7
34.4
iu/ml
—
9
116
13
138
0.94
0.02
1.7
2.1
—
—
—
0
0
16
152
1.06
0.02
1.6
1.3
245.3
148.9
iu/ml
—
6
65
5
53
0.94
0.00
1.0
1.2
—
—
—
0
0
8
87
0.92
0.00
1.1
1.4
27.1
19.6
iu/l
—
8
75
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
5
52
0.96
0.00
1.4
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
11
110
1.00
0.00
1.3
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
19.7
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint H7_RETINALDETACHTRACTION and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINALDETACHTRACTION | 1.481 [1.22, 1.8] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.324 |
During the follow-up period (1.1.1998 — 31.12.2019), 260 out of 846 females with H7_RETINALDETACHTRACTION died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINALDETACHTRACTION | 1.619 [1.36, 1.92] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.038 |
During the follow-up period (1.1.1998 — 31.12.2019), 306 out of 960 males with H7_RETINALDETACHTRACTION died.
Mortality risk
Mortality risk for people of age
years, who have H7_RETINALDETACHTRACTION.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.144% | 0.386% |
| 5 | 0.809% | 1.958% |
| 10 | 2.047% | 5.02% |
| 15 | 4.393% | 9.748% |
| 20 | 7.447% | 17.063% |
Relationships between endpoints
↥Index endpoint: H7_RETINALDETACHTRACTION – Traction detachment of retina
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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