No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
189 |
4. Check minimum number of eventsNone |
189 |
5. Include endpointsNone |
189 |
6. Filter based on genotype QC (FinnGen only) |
189 |
Control definitions (FinnGen only)
- Control exclude
- H8_OTHEREAR
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H91
- Name in latin
- Surdomutitas non alibi classificata
Similar endpoints
↥List of similar endpoints to
Deaf mutism, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other hearing loss
- Other disorders of ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2290 | 1093 | 1167 |
| Only index persons | 1776 | 903 | 873 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 43.90 | 44.20 | 43.06 |
| Only index persons | 35.92 | 40.27 | 31.41 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 189 | 101 | 88 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | 46.97 | 42.74 | 51.82 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 180
- Matched controls
- 1799
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H91.3
ICD-10 Finland
Deaf mutism, not elsewhere classified
+∞
110.0
94
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
210.7
106.3
102
11
3897A
ICD-9 Finland
Deafness, Deaf mutism, not elsewhere classifiable[SURDITAS]
+∞
62.1
56
*
H90.5
ICD-10 Finland
Sensorineural hearing loss, unspecified
+∞
23.4
22
*
N07CA01
ATC
betahistine; oral
13.0
23.2
42
41
38801
ICD-8 Finland
Deaf mutism, Congenita
+∞
22.4
21
*
DFF00
NOMESCO Finland
Pure tone audiometry
17.1
22.0
35
25
H93.1
ICD-10 Finland
Tinnitus
31.4
20.7
27
10
Z97.4
ICD-10 Finland
Presence of external hearing-aid
45.7
20.1
24
6
R5430
NOMESCO Finland
Interpreter's services
211.1
18.9
19
*
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
19.6
18.1
27
16
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
186.6
16.8
17
*
H91.2
ICD-10 Finland
Sudden idiopathic hearing loss
162.7
14.7
15
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
6.7
14.0
37
67
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
13.7
13
*
38900
ICD-8 Finland
Other deafness, Deafness, both ears
+∞
13.7
13
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
6.0
13.5
39
79
DFF15
NOMESCO Finland
Speech audiometry
22.0
12.7
18
9
DFE00
NOMESCO Finland
Insertion of cochlear implant
+∞
12.6
12
*
3891A
ICD-9 Finland
Deafness, Sensorineural deafness
+∞
11.6
11
*
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
+∞
11.6
11
*
R5120
NOMESCO Finland
Preparation of an aid
27.1
11.3
15
6
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
7.4
11.3
27
42
38809
ICD-8 Finland
Deaf mutism, Unspecified
+∞
10.5
10
*
DFX00
NOMESCO Finland
Connecting cochlear implant
+∞
10.5
10
*
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
34.8
10.5
13
*
H91.9
ICD-10 Finland
Hearing loss, unspecified
20.3
10.5
15
8
UDC00
NOMESCO Finland
Ear microscopy
8.5
10.3
22
29
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
31.9
9.5
12
*
3897B
ICD-9 Finland
Deafness, Deaf mutism, not elsewhere classifiable[SURDOMUTITAS]
+∞
9.5
9
*
38990
ICD-8 Finland
Other deafness, Partialis uni-sive bilateralis
+∞
9.5
9
*
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
9.5
9
*
RK520
NOMESCO Finland
NA
+∞
8.4
8
*
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
4.9
8.3
27
63
DC1AD
NOMESCO Finland
Temporalbone CT
83.4
7.5
8
*
3882A
ICD-9 Finland
Other disorders of ear, Sudden hearing loss, unspecified
+∞
7.3
7
*
38800
ICD-8 Finland
Deaf mutism, Acquisita
+∞
7.3
7
*
R42
ICD-10 Finland
Dizziness and giddiness
2.9
7.3
48
200
DAX08
NOMESCO Finland
Fitting of hearing aid
21.0
7.2
10
5
RK320
NOMESCO Finland
NA
23.5
6.7
9
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.9
6.3
39
155
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
41
161
2.98
7.93
5.3
4.2
30.8
32.4
%
0.33
26
104
49
232
2.50
6.52
2.1
1.6
1375.9
1184.9
nmol/l
0.62
33
187
54
269
2.41
6.43
1.8
1.7
147500462.3
441.1
pmol/l
0.49
40
233
85
538
2.05
5.46
4.7
3.7
31.3
32.0
ng/l
0.04
68
384
67
420
1.92
4.21
2.3
2.0
154.1
216.3
u/l
0.69
67
399
33
158
2.32
4.19
6.1
8.6
—
—
—
0
0
90
638
1.78
3.72
4.2
3.5
—
—
—
0
0
53
330
1.84
3.30
2.4
2.1
—
—
—
0
0
52
323
1.84
3.26
3.6
1.9
3.3
3.1
mg/l
0.21
42
277
95
704
1.70
3.22
6.7
6.4
1.2
1.2
mmol/l
0.40
76
603
87
638
1.67
3.01
11.7
5.3
1.2
1.2
mmol/l
0.51
72
587
135
1117
1.73
2.90
7.7
7.2
76.6
79.1
u/l
0.41
122
1049
81
592
1.64
2.79
5.6
4.2
35.9
35.5
g/l
0.27
70
561
17
74
2.43
2.67
1.7
1.3
—
—
—
0
0
60
415
1.65
2.52
2.9
2.9
3565.6
1241.1
ng/l
0.93
47
354
6
12
5.12
2.42
1.5
1.3
—
—
—
0
0
12
46
2.72
2.41
2.4
1.8
—
—
—
0
0
12
47
2.66
2.32
2.4
1.9
—
—
—
0
0
62
441
1.60
2.30
2.6
2.4
53.2
55.1
u/l
0.18
54
411
76
568
1.57
2.29
2.5
1.9
97.1
97.5
pmol/l
0.02
37
288
126
1059
1.57
2.21
4.4
3.8
14.9
14.9
pmol/l
0.01
103
966
9
31
3.00
2.10
3.7
1.3
—
—
—
0
0
148
1301
1.63
2.05
5.4
4.5
1.9
1.9
mu/l
0.01
126
1187
161
1447
1.76
2.04
22.1
15.3
139.6
139.7
mmol/l
0.33
153
1406
161
1451
1.74
1.97
22.2
15.5
4.0
4.0
mmol/l
0.60
154
1409
8
27
3.05
1.96
2.3
1.1
—
—
—
0
0
6
18
3.41
1.76
1.0
1.2
—
—
—
0
0
111
935
1.45
1.73
4.1
2.9
52.7
47.6
u/l
0.31
96
882
48
347
1.51
1.62
1.7
1.5
22.5
22.1
nmol/l
0.04
34
295
29
188
1.64
1.54
3.6
2.1
2.4
2.3
g/l
0.40
22
171
11
51
2.23
1.54
2.3
2.8
—
—
—
0
0
91
754
1.40
1.47
5.3
6.3
9.2
11.1
umol/l
1.97
81
717
31
207
1.60
1.47
3.6
2.2
12.5
13.8
umol/l
0.50
25
191
72
577
1.40
1.40
4.1
2.5
100.3
113.5
ug/l
0.28
61
532
27
177
1.61
1.38
4.0
2.2
21.4
23.3
%
0.31
19
158
163
1513
1.56
1.30
12.4
10.2
25.3
25.9
u/l
0.19
151
1472
145
1317
1.43
1.28
7.2
5.5
40.6
40.0
mmol/mol
0.27
127
1238
60
477
1.38
1.20
2.9
3.5
2.3
2.4
mmol/l
0.43
46
431
22
143
1.61
1.18
4.2
3.3
—
—
—
0
0
19
120
1.65
1.13
1.9
1.9
—
—
—
0
0
20
129
1.62
1.11
2.4
2.5
3.8
6.1
ug/l
0.50
13
114
7
33
2.16
1.06
1.1
1.4
—
—
—
0
0
31
224
1.46
1.05
2.2
1.7
—
—
—
0
0
46
358
1.38
1.04
6.0
4.0
0.0
0.0
estimate
0.00
20
123
146
1346
1.37
1.02
15.7
12.8
77.1
80.2
ml/min/173m2
0.89
123
1108
7
37
1.93
0.95
1.6
1.2
—
—
—
0
0
14
86
1.68
0.94
2.1
1.5
—
—
—
0
0
166
1575
1.44
0.87
26.6
19.9
133.7
135.6
g/l
0.95
160
1550
62
518
1.29
0.87
5.6
3.9
—
—
—
0
0
6
33
1.84
0.79
1.5
1.3
—
—
—
0
0
118
1076
1.26
0.78
4.5
4.0
13.5
12.8
mm/h
0.21
102
989
6
34
1.79
0.77
1.0
1.1
—
—
—
0
0
16
110
1.50
0.71
1.9
1.8
—
—
—
0
0
77
679
1.23
0.66
5.1
3.7
0.0
0.0
estimate
0.00
21
131
5
30
1.68
0.62
2.4
1.2
—
—
—
0
0
5
30
1.68
0.62
1.0
1.1
—
3.9
—
0
6
10
64
1.59
0.60
5.7
4.0
24.0
24.4
mmol/l
—
10
59
0
22
0.00
0.59
0.0
1.2
—
1.4
—
0
7
0
23
0.00
0.58
0.0
1.2
—
4.8
—
0
12
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
9
61
1.50
0.54
1.2
1.9
—
—
—
0
0
77
691
1.19
0.54
5.4
3.7
0.0
0.0
estimate
0.00
22
125
6
39
1.56
0.53
1.8
1.2
—
—
—
0
0
66
588
1.19
0.49
3.3
2.1
76.5
76.2
nmol/l
0.03
54
531
51
445
1.20
0.48
4.1
4.6
1.8
2.4
ug/l
0.43
42
395
22
274
0.78
0.47
2.4
2.7
0.8
0.9
ug/l
0.05
12
176
7
48
1.48
0.47
2.0
2.6
—
—
—
0
0
75
680
1.17
0.45
6.6
5.1
0.0
0.0
estimate
0.00
22
130
148
1417
1.20
0.45
18.7
13.6
23.3
22.5
mg/l
0.09
124
1121
92
850
1.16
0.43
3.3
3.0
—
—
—
0
0
35
298
1.21
0.42
2.0
1.8
1.0
1.1
mg/l
0.22
27
225
0
19
0.00
0.39
0.0
1.6
—
—
—
0
0
12
89
1.37
0.39
1.0
1.2
121.7
143.8
iu/ml
—
7
29
6
42
1.44
0.36
2.5
1.4
—
—
—
0
0
27
228
1.21
0.36
2.2
1.9
29.9
29.7
s
0.09
27
221
10
73
1.39
0.35
9.2
7.2
25.7
25.0
mmol/l
—
10
73
17
208
0.80
0.33
1.1
1.4
—
—
—
0
0
143
1379
1.15
0.32
5.4
4.4
6.0
6.0
mmol/l
0.19
120
1263
148
1431
1.16
0.32
5.5
4.8
2.6
2.8
mmol/l
1.04
126
1317
24
277
0.85
0.27
2.8
3.0
2.4
2.4
mmol/l
0.26
18
248
19
160
1.21
0.26
1.9
1.5
—
—
—
0
0
31
349
0.87
0.26
3.3
4.1
24.9
22.2
%
0.32
14
155
5
40
1.26
0.22
1.4
1.4
—
—
—
0
0
5
41
1.23
0.22
1.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.4
—
—
—
0
0
0
11
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
522.8
—
0
5
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
38.7
—
0
5
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
5.0
—
0
6
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
32
289
1.13
0.20
1.5
1.2
1.1
1.6
u/ml
—
6
82
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
14
163
0.85
0.18
1.9
4.6
3.1
48.3
ug/l
—
8
142
54
509
1.09
0.16
5.1
2.9
—
—
—
0
0
88
846
1.08
0.16
8.3
9.7
4.1
4.0
e9/l
0.34
76
747
25
226
1.12
0.16
1.4
1.5
—
—
—
0
0
10
83
1.22
0.16
3.5
3.3
4.4
4.5
pmol/l
—
10
71
143
1402
1.08
0.14
5.2
4.4
4.5
4.7
mmol/l
0.84
121
1306
126
1288
0.93
0.13
15.2
14.3
38.8
39.9
%
0.48
69
964
26
240
1.10
0.12
1.2
1.2
3.8
9.8
u/ml
0.68
12
99
28
261
1.09
0.10
3.1
3.3
1156.5
134.9
ng/l
0.45
21
201
26
242
1.09
0.10
3.9
2.6
1.2
0.9
e6/l
0.33
17
132
10
87
1.16
0.09
3.4
6.9
25.1
24.4
mmol/l
—
10
81
6
56
1.07
0.09
1.0
1.2
—
—
—
0
0
6
56
1.07
0.09
1.0
1.2
—
—
—
0
0
37
352
1.06
0.08
1.9
2.8
348.5
9789.0
umol/l
2.20
28
313
38
398
0.94
0.08
4.9
2.9
0.4
0.4
e6/l
0.05
28
290
18
166
1.09
0.08
2.0
1.6
—
—
—
0
0
44
458
0.95
0.08
3.5
2.9
28.7
29.4
u/l
0.14
38
438
141
1392
1.05
0.07
5.3
4.3
1.5
1.5
mmol/l
0.04
120
1284
12
130
0.92
0.05
1.2
1.7
—
—
—
0
0
23
241
0.95
0.04
1.2
1.3
48.0
39.6
iu/ml
—
9
94
136
1348
1.03
0.04
4.8
3.9
1.3
1.3
mmol/l
0.09
115
1235
23
229
1.00
0.00
3.7
2.8
1.9
2.4
e6/l
0.27
13
122
38
383
0.99
0.00
1.8
1.7
1.5
1.4
mmol/l
0.17
30
322
11
105
1.05
0.00
2.0
3.1
45.2
63.2
ml/min/173m2
—
6
39
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.9
—
956.1
—
0
7
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
5
51
0.98
0.00
1.0
1.8
—
—
—
0
0
6
65
0.92
0.00
1.3
1.0
—
—
—
0
0
9
95
0.94
0.00
2.1
1.5
—
—
—
0
0
8
83
0.96
0.00
1.6
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.3
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_HL_DEAFMUT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_HL_DEAFMUT | 0.972 [0.76, 1.25] | 0.828 |
| Birth year | 0.994 [0.99, 1.0] | 0.144 |
During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 364 females with H8_HL_DEAFMUT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_HL_DEAFMUT | 1.274 [0.94, 1.72] | 0.117 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 329 males with H8_HL_DEAFMUT died.
Mortality risk
Mortality risk for people of age
years, who have H8_HL_DEAFMUT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.062% | 0.198% |
| 5 | 0.475% | 1.537% |
| 10 | 1.164% | 3.742% |
| 15 | 2.581% | 6.891% |
| 20 | 4.467% | 12.099% |
Relationships between endpoints
↥Index endpoint: H8_HL_DEAFMUT – Deaf mutism, not elsewhere classified
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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