Acquired stenosis of external ear canal

H8_STENOEXTCAN

auditory system disease: Pathological processes of the ear, the hearing, and the equilibrium system of the body.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H61.3
  • Hospital discharge: ICD-9 3805
  • Cause of death: ICD-10 H61.3
  • Cause of death: ICD-9 3805

2 out of 7 registries used, show all original rules.

323

4. Check minimum number of events

None

323

5. Include endpoints

None

323

6. Filter based on genotype QC (FinnGen only)

323

Control definitions (FinnGen only)

Control exclude
H8_EXTERNAL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H61
Name in latin
Stenosis meatus acustici externi acquisita

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1833 644 1188
Only index persons 1756 613 1143
Unadjusted period prevalence (%)
Whole population 0.03 0.02 0.03
Only index persons 0.04 0.02 0.04
Median age at first event (years)
Whole population 57.68 56.60 58.25
Only index persons 57.63 56.73 58.11

-FinnGen-

Key figures

All Female Male
Number of individuals 323 100 223
Unadjusted period prevalence (%) 0.08 0.03 0.10
Median age at first event (years) 60.36 55.17 62.69

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
282
Matched controls
2817
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H61.3
ICD-10 Finland
Acquired stenosis of external ear canal
4503599627370496.0
323.0
274
*
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
1148.3
143.2
128
*
H61.8
ICD-10 Finland
Other specified disorders of external ear
397.2
64.2
62
*
UDC00
NOMESCO Finland
Ear microscopy
14.2
52.2
95
97
DFF00
NOMESCO Finland
Pure tone audiometry
10.7
45.5
96
129
Z01.1
ICD-10 Finland
Examination of ears and hearing
7.3
35.2
96
187
H60.8
ICD-10 Finland
Other otitis externa
43.6
31.1
38
10
H60.3
ICD-10 Finland
Other infective otitis externa
56.7
30.1
35
7
H60.9
ICD-10 Finland
Otitis externa, unspecified
12.8
29.6
54
51
DBB00
NOMESCO Finland
Excision of lesion of external auditory canal
+∞
25.4
24
*
H71
ICD-10 Finland
Cholesteatoma of middle ear
31.6
20.0
26
9
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
22.0
19.5
28
14
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
3.8
16.3
78
257
DC1AD
NOMESCO Finland
Temporalbone CT
35.7
16.0
20
6
H61.2
ICD-10 Finland
Impacted cerumen
7.7
14.6
34
49
H60
ICD-10 Finland
Otitis externa
8.8
13.7
29
36
H65.3
ICD-10 Finland
Chronic mucoid otitis media
17.3
13.7
21
13
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
14.2
12.1
20
15
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
62.4
10.7
12
*
TDA90
NOMESCO Finland
Removal wax from ear
18.3
9.5
14
8
DBD30
NOMESCO Finland
Correction of atresia of external auditory canal
+∞
9.4
9
*
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
6.7
9.3
23
37
Z97.4
ICD-10 Finland
Presence of external hearing-aid
6.0
9.0
24
43
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
51.6
8.7
10
*
R5120
NOMESCO Finland
Preparation of an aid
7.5
8.4
19
27
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
11.2
8.4
15
14
4111
FHL
Ear canal extension
+∞
8.4
8
*
3805A
ICD-9 Finland
Disorders of external ear, Acquired stenosis of external ear canal
+∞
8.4
8
*
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)
6.4
8.3
21
35
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
8.3
94
506
H66.0
ICD-10 Finland
Acute suppurative otitis media
4.5
8.2
28
67
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.4
7.8
72
350
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)
7.5
7.6
17
24
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
+∞
7.3
7
*
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
+∞
7.3
7
*
DFF15
NOMESCO Finland
Speech audiometry
4.9
7.1
22
48
ZXA10
NOMESCO Finland
Bilateral
2.4
7.0
61
287
WX002
NOMESCO Finland
Sedation and analgesia
2.3
6.9
68
338
H60.4
ICD-10 Finland
Cholesteatoma of external ear
41.0
6.8
8
*
J01DB01
ATC
cefalexin; oral
2.2
6.7
233
1922
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
6.5
6.6
16
26
H01
ICPC
Ear pain/earache
3.4
6.6
30
94
D07AB02
ATC
hydrocortisone butyrate; topical
2.1
6.5
83
464
H66.9
ICD-10 Finland
Otitis media, unspecified
4.7
6.3
20
45
Q16.1
ICD-10 Finland
Congenital absence, atresia and stricture of auditory canal (external)
+∞
6.3
6
*
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
4.9
6.2
19
41

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
78
323
2.87
13.43
2.3
1.8
—
—
—
0
0
67
331
2.29
7.69
1.7
1.4
—
—
—
0
0
74
430
1.94
5.44
2.0
2.1
—
—
—
0
0
234
1942
1.74
4.72
3.9
4.0
—
—
—
0
0
123
902
1.59
3.80
6.4
5.9
—
—
—
0
0
32
589
0.49
3.63
3.0
3.9
1.0
1.0
kg/l
—
5
85
24
105
2.39
3.62
1.1
1.2
—
—
—
0
0
288
2615
1.94
3.43
4.6
4.7
6.0
6.1
mmol/l
0.52
261
2393
307
2862
2.47
3.27
11.2
10.9
25.9
27.9
u/l
1.72
298
2781
152
1199
1.51
3.25
9.9
9.8
0.0
0.0
e9/l
0.62
120
989
53
328
1.74
3.12
1.7
1.3
—
—
—
0
0
156
1256
1.47
2.92
6.2
5.8
2.9
2.9
%
0.04
147
1190
294
2716
1.92
2.89
4.7
5.1
2.7
2.7
mmol/l
0.14
268
2505
252
2242
1.56
2.80
17.6
18.3
13.7
13.8
%
0.31
245
2204
156
1267
1.45
2.73
6.5
6.1
9.0
8.9
%
0.24
148
1206
151
1222
1.44
2.68
6.2
5.8
0.7
0.6
%
1.17
143
1159
158
1291
1.44
2.66
6.3
5.9
27.1
26.7
%
0.15
149
1219
104
786
1.48
2.63
3.9
4.2
7.4
7.4
ph
0.31
26
155
165
1366
1.43
2.55
5.7
5.9
2.1
1.8
e9/l
0.50
151
1219
162
1338
1.42
2.53
5.8
5.8
0.6
0.6
e9/l
0.41
143
1167
268
2437
1.59
2.51
16.1
15.8
41.0
40.3
%
0.88
198
1728
162
1340
1.42
2.50
5.8
5.9
0.0
0.0
e9/l
0.43
143
1179
298
2787
1.89
2.49
17.7
17.4
139.7
139.6
mmol/l
0.18
292
2734
155
1274
1.42
2.47
5.9
5.7
57.2
57.6
%
0.20
148
1211
218
1905
1.44
2.45
3.2
3.6
14.6
14.9
pmol/l
1.62
201
1704
312
2970
2.48
2.41
22.7
21.9
241.9
240.8
e9/l
0.11
303
2905
165
1375
1.41
2.41
5.9
6.1
0.2
0.2
e9/l
0.24
147
1230
312
2972
2.46
2.37
22.6
21.8
30.4
30.5
pg
0.25
307
2940
312
2972
2.46
2.37
22.7
21.8
91.2
91.2
fl
0.00
307
2940
312
2973
2.45
2.35
22.8
21.9
4.5
4.5
e12/l
0.02
301
2897
184
1567
1.40
2.34
7.9
9.7
4.1
4.2
e9/l
0.33
158
1386
312
2974
2.44
2.33
22.8
21.9
6.7
6.7
e9/l
0.06
300
2899
78
569
1.49
2.33
2.1
2.5
2.8
4.1
e6/l
1.05
62
505
312
2975
2.43
2.31
22.9
22.0
137.7
137.6
g/l
0.06
307
2939
298
2798
1.84
2.29
17.9
17.5
4.0
4.0
mmol/l
0.45
292
2747
9
212
0.41
2.29
2.4
3.7
—
—
—
0
0
41
260
1.66
2.23
1.8
1.4
—
—
—
0
0
287
2677
1.65
2.13
4.5
4.6
4.6
4.5
mmol/l
0.70
265
2484
259
2364
1.48
2.11
4.5
4.3
2.0
1.9
mu/l
0.14
233
2139
118
953
1.38
1.98
3.2
3.6
49.6
57.3
e6/l
0.12
77
703
96
749
1.40
1.98
1.6
1.7
1.4
1.4
mmol/l
0.19
75
627
10
39
2.61
1.94
3.5
3.2
—
—
—
0
0
221
1977
1.37
1.89
3.8
4.1
11.7
11.7
mm/h
0.01
204
1829
106
847
1.37
1.89
4.0
3.6
2.4
2.3
mmol/l
1.10
99
750
124
1016
1.36
1.89
2.9
2.1
—
—
—
0
0
296
2803
1.67
1.79
14.7
14.3
—
—
—
0
0
127
1053
1.34
1.76
2.7
2.7
139.5
156.8
ug/l
0.41
113
965
5
13
3.89
1.72
1.2
1.0
162.2
152.6
nmol/l
—
5
13
56
406
1.46
1.72
1.3
1.3
17.8
33.8
iu/ml
1.44
17
132
34
221
1.60
1.71
3.6
4.1
1.2
1.2
mmol/l
0.50
29
198
284
2671
1.52
1.69
15.6
15.0
28.0
25.4
mg/l
0.54
232
2146
186
1637
1.32
1.68
4.0
5.0
6.7
6.8
mmol/l
0.04
175
1536
35
232
1.57
1.63
1.8
1.4
—
—
—
0
0
7
26
2.73
1.59
1.3
1.4
—
—
nmol/l
—
0
0
6
20
3.04
1.59
1.7
1.9
—
—
—
0
0
36
243
1.54
1.55
2.1
2.5
35.9
227.8
u/l
0.49
30
209
46
328
1.47
1.54
1.3
1.4
354.3
541.8
titre
—
7
68
40
277
1.51
1.54
1.7
1.5
—
—
—
0
0
44
311
1.48
1.54
2.4
2.2
13.5
13.8
nmol/l
0.05
33
280
282
2659
1.48
1.54
4.2
4.5
1.4
1.4
mmol/l
0.07
258
2449
270
2534
1.40
1.43
5.5
6.1
39.5
40.4
mmol/mol
1.01
246
2367
33
224
1.53
1.40
4.4
3.3
—
—
—
0
0
229
2103
1.31
1.37
7.8
8.1
78.5
79.1
u/l
0.08
206
1978
5
17
2.97
1.36
1.6
1.6
—
—
—
0
0
16
90
1.82
1.35
2.3
1.7
—
—
—
0
0
19
113
1.72
1.35
1.1
1.7
—
—
—
0
0
72
571
1.34
1.32
1.3
1.8
1.0
1.4
mg/l
1.06
54
453
6
24
2.53
1.31
1.3
1.2
—
—
—
0
0
10
48
2.12
1.29
5.3
3.9
49.6
58.8
%
—
10
48
79
643
1.30
1.21
2.1
2.1
2.7
3.0
mg/l
0.81
66
551
82
671
1.30
1.20
5.7
7.1
—
—
—
0
0
6
26
2.33
1.19
1.2
1.4
—
—
—
0
0
0
34
0.00
1.16
0.0
2.2
—
—
—
0
0
7
30
2.36
1.13
1.3
1.2
—
—
—
0
0
100
846
1.26
1.13
3.0
3.1
28.8
127.2
e6/l
0.69
71
659
89
743
1.27
1.12
3.1
2.9
—
—
—
0
0
13
75
1.76
1.04
1.1
1.1
—
—
—
0
0
163
1466
1.23
1.04
5.1
4.7
2.1
2.2
ug/l
0.16
144
1317
66
536
1.29
1.03
2.5
2.8
588.4
579.6
mosm/kgh2o
0.11
50
465
9
47
1.94
1.03
3.7
3.1
3.0
4.9
e9/l
—
9
47
101
867
1.24
0.99
3.0
2.9
0.8
0.7
ug/l
0.17
64
558
5
23
2.19
0.98
1.0
1.7
1.1
1.0
g/l
—
5
23
0
29
0.00
0.98
0.0
1.2
—
2.3
—
0
6
0
29
0.00
0.98
0.0
3.7
—
21.6
—
0
24
9
50
1.82
0.97
1.1
1.3
—
—
—
0
0
62
504
1.28
0.96
3.6
3.9
171.1
326.9
ng/l
0.62
52
415
33
244
1.39
0.95
5.1
6.9
1.5
1.3
mmol/l
0.35
33
231
135
1200
1.21
0.95
5.0
6.0
1.2
1.2
mmol/l
0.09
128
1094
98
843
1.23
0.94
3.1
3.2
55.3
256.8
mg/l
1.01
65
569
146
1308
1.21
0.94
6.3
7.1
1.2
1.2
mmol/l
0.51
115
1115
49
387
1.31
0.94
1.3
1.3
6.3
10.8
u/ml
0.34
13
153
143
1280
1.21
0.93
3.9
4.2
—
—
—
0
0
102
883
1.23
0.92
2.9
3.0
8.7
8.3
mmol/l
0.36
78
729
71
593
1.25
0.89
3.9
4.6
—
—
—
0
0
14
87
1.64
0.89
1.7
1.7
37.7
37.7
g/l
0.01
14
72
30
222
1.39
0.87
5.6
8.4
—
—
—
0
0
21
145
1.48
0.87
1.3
1.3
—
—
—
0
0
269
2572
1.27
0.87
4.0
4.1
1.4
1.3
mmol/l
1.23
248
2358
17
112
1.55
0.86
1.3
1.1
—
—
—
0
0
14
88
1.62
0.86
1.2
1.2
—
—
—
0
0
6
31
1.95
0.85
1.3
1.4
—
—
—
0
0
10
57
1.78
0.84
1.1
1.2
—
—
—
0
0
13
81
1.63
0.82
3.2
3.5
—
—
—
0
0
21
149
1.44
0.78
6.4
9.4
24.7
24.7
mmol/l
0.02
21
139
121
1085
1.18
0.74
1.9
1.9
90.8
95.2
pmol/l
0.43
54
600
88
768
1.20
0.73
3.2
3.0
0.2
0.5
e6/l
1.36
58
583
5
25
2.02
0.73
1.8
2.4
—
—
—
0
0
159
1462
1.17
0.72
6.0
7.1
12.0
12.0
umol/l
0.02
151
1394
9
57
1.60
0.71
1.1
2.0
—
—
—
0
0
86
755
1.19
0.67
2.3
2.8
5856.4
5410.2
umol/l
0.03
73
657
25
189
1.35
0.67
1.1
1.2
—
—
—
0
0
14
201
0.68
0.66
2.6
5.1
—
—
—
0
0
5
28
1.80
0.66
2.4
1.4
—
—
—
0
0
100
892
1.18
0.65
3.9
3.8
9.3
8.6
mg/mmol
0.07
62
593
18
129
1.42
0.65
1.3
1.2
—
15.6
—
0
5
16
113
1.44
0.62
2.1
1.9
416.7
681.8
ug/l
0.27
16
105
62
717
0.83
0.62
3.6
3.0
—
—
—
0
0
5
30
1.68
0.61
1.2
1.1
—
—
—
0
0
5
30
1.68
0.61
4.4
3.5
—
—
—
0
0
21
157
1.36
0.61
4.9
8.7
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
43
356
1.24
0.60
1.3
1.3
—
—
—
0
0
0
21
0.00
0.60
0.0
1.6
—
—
—
0
0
0
22
0.00
0.59
0.0
1.5
—
—
—
0
0
37
302
1.25
0.59
1.4
1.4
—
—
—
0
0
13
184
0.69
0.58
1.8
1.6
—
—
—
0
0
26
329
0.77
0.58
1.3
1.6
—
—
—
0
0
6
36
1.68
0.57
4.7
2.1
32.3
34.0
pg
—
6
36
5
89
0.55
0.56
4.2
11.3
—
—
—
0
0
8
125
0.63
0.55
4.1
3.5
29.9
400.4
u/ml
—
8
102
9
62
1.46
0.53
1.2
1.4
—
—
—
0
0
13
179
0.71
0.51
6.7
3.5
123.2
128.7
g/l
0.38
13
174
59
515
1.18
0.50
1.5
1.4
2.5
2.7
g/l
0.41
33
319
12
84
1.45
0.50
2.8
3.3
0.1
0.2
g/l
—
5
36
25
201
1.26
0.46
1.4
1.4
—
—
—
0
0
64
719
0.86
0.46
3.6
3.8
0.0
0.0
estimate
0.68
31
244
19
241
0.78
0.45
2.9
4.0
—
—
—
0
0
95
868
1.13
0.44
2.5
2.4
—
—
—
0
0
7
51
1.38
0.44
1.6
1.4
—
—
—
0
0
9
128
0.69
0.44
2.1
2.2
1.4
3.8
ug/l
—
9
115
5
31
1.62
0.43
1.4
1.2
—
—
—
0
0
8
57
1.41
0.42
3.6
3.1
—
—
—
0
0
5
32
1.57
0.42
2.4
1.5
—
—
—
0
0
5
32
1.57
0.42
1.0
1.1
—
—
—
0
0
5
32
1.57
0.42
1.0
1.1
—
—
—
0
0
126
1175
1.12
0.42
9.5
9.7
1.3
1.2
inr
0.43
41
341
0
15
0.00
0.41
0.0
2.3
—
—
—
0
0
0
15
0.00
0.41
0.0
2.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.7
—
—
—
0
0
12
88
1.38
0.40
1.2
1.3
—
3.8
—
0
7
0
18
0.00
0.40
0.0
1.1
—
1.8
—
0
18
24
197
1.24
0.39
4.0
3.9
0.0
0.2
%
—
9
54
43
376
1.17
0.37
3.1
2.4
20.8
23.1
%
0.68
37
320
5
37
1.36
0.37
2.8
1.7
—
—
—
0
0
25
298
0.83
0.36
1.6
1.6
—
—
—
0
0
39
339
1.17
0.36
2.3
3.4
12.8
9.5
umol/l
0.22
30
302
31
264
1.19
0.36
1.9
2.5
0.2
0.2
g/l
0.60
31
242
54
483
1.14
0.35
1.9
1.7
1178.2
1193.3
nmol/l
0.04
40
373
10
73
1.38
0.35
1.1
2.0
8.3
11.6
mg/l
—
10
67
24
200
1.22
0.35
4.2
3.6
0.6
0.4
%
—
8
49
6
44
1.37
0.34
1.0
1.3
—
—
—
0
0
89
823
1.11
0.34
2.4
2.1
256.3
278.7
u/l
0.08
84
780
31
358
0.85
0.33
30.5
23.6
1.2
1.3
inr
—
9
47
88
818
1.10
0.31
3.9
3.9
—
—
—
0
0
52
574
0.89
0.30
1.6
1.8
405.9
23809958.2
pmol/l
0.50
43
483
69
749
0.90
0.30
3.1
3.0
—
—
—
0
0
7
55
1.28
0.30
2.7
2.4
—
—
—
0
0
10
129
0.77
0.28
1.8
3.0
—
—
—
0
0
13
103
1.27
0.28
1.0
1.0
—
—
—
0
0
9
117
0.76
0.28
2.2
4.1
—
—
—
0
0
126
1323
0.92
0.27
3.1
3.5
0.0
0.0
estimate
0.00
28
241
15
122
1.24
0.27
2.1
4.6
25.0
24.4
mmol/l
0.74
15
112
18
151
1.20
0.25
1.1
1.6
—
—
—
0
0
18
151
1.20
0.25
2.7
2.9
—
—
—
0
0
9
76
1.19
0.25
2.7
3.1
7.4
7.4
ph
—
9
64
24
208
1.17
0.24
4.2
3.8
0.1
0.2
%
—
9
62
13
158
0.82
0.24
1.1
1.2
—
—
—
0
0
28
247
1.15
0.23
4.2
2.7
76.4
68.9
e9/l
0.42
21
189
189
1834
1.07
0.23
4.3
4.0
—
—
—
0
0
59
547
1.10
0.22
1.2
1.2
7.5
1.1
u/ml
—
10
156
5
41
1.22
0.22
1.8
2.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
5
43
1.17
0.21
1.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
10
80
1.26
0.20
1.1
1.1
—
—
—
0
0
6
48
1.25
0.20
2.8
2.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
5198.1
—
0
7
12
144
0.83
0.20
6.4
3.5
24.3
25.0
mmol/l
0.29
12
138
7
61
1.15
0.17
1.7
1.3
—
—
—
0
0
6
77
0.78
0.16
1.0
1.2
—
—
—
0
0
25
226
1.12
0.15
4.3
3.8
1.0
1.0
%
—
9
71
22
244
0.89
0.15
1.3
1.4
—
—
—
0
0
41
382
1.08
0.15
1.5
1.8
—
—
—
0
0
9
83
1.09
0.15
1.3
1.2
—
—
—
0
0
23
208
1.11
0.14
1.2
1.4
—
—
—
0
0
33
305
1.09
0.14
2.2
2.3
253.7
143.3
ug/g
0.33
23
251
21
189
1.12
0.14
2.1
2.4
—
—
—
0
0
43
458
0.93
0.14
2.1
2.1
30.6
29.7
s
0.49
43
444
11
94
1.18
0.13
1.6
1.6
—
—
—
0
0
121
1175
1.05
0.13
5.6
5.4
34.7
35.4
g/l
0.68
108
1104
84
810
1.05
0.12
3.9
4.5
—
—
—
0
0
16
143
1.13
0.11
1.9
2.3
—
—
—
0
0
39
367
1.07
0.11
6.4
6.7
104.4
104.0
mmol/l
0.25
39
356
5
48
1.04
0.09
1.0
1.5
—
—
—
0
0
6
58
1.04
0.08
1.3
1.3
—
—
—
0
0
5
61
0.82
0.08
1.2
1.5
—
245.6
—
0
30
17
156
1.09
0.08
1.2
1.4
—
—
—
0
0
128
1304
0.97
0.07
4.1
4.7
0.0
0.0
estimate
0.00
32
258
6
72
0.83
0.07
1.0
1.3
—
—
—
0
0
18
194
0.92
0.07
2.3
2.4
—
—
—
0
0
20
187
1.07
0.06
5.1
4.1
132.4
85.3
ng/l
0.69
13
173
115
1131
1.03
0.06
3.4
3.8
23.0
41.7
ng/l
2.88
80
835
13
141
0.92
0.05
1.9
3.4
—
—
—
0
0
14
131
1.07
0.03
1.1
1.2
59.6
178.7
iu/ml
—
5
44
99
1002
0.98
0.03
2.9
2.9
—
—
—
0
0
92
909
1.02
0.02
2.8
2.7
55.1
57.4
u/l
0.26
75
846
24
232
1.04
0.02
2.1
2.8
65.3
66.2
g/l
0.29
24
215
26
266
0.98
0.00
4.2
4.2
—
—
—
0
0
65
652
1.00
0.00
1.6
1.6
20.7
20.4
nmol/l
0.07
59
561
75
749
1.00
0.00
1.4
1.4
—
—
—
0
0
17
167
1.02
0.00
1.4
2.9
0.1
0.2
e6/l
1.54
17
161
11
106
1.04
0.00
1.5
1.5
—
—
—
0
0
26
256
1.02
0.00
4.2
4.1
6.3
5.8
kpa
1.36
26
244
59
594
0.99
0.00
2.5
3.5
—
—
—
0
0
129
1295
0.99
0.00
2.9
3.5
0.0
0.0
estimate
0.00
31
251
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
8.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
4.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
0.00
2.6
3.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
2.1
—
0
5
7
75
0.93
0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
7
76
0.92
0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
4.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
6
65
0.92
0.00
1.3
1.2
—
—
—
0
0
7
76
0.92
0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
18.5
—
0
7
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
10835.4
—
0
7
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
8
82
0.97
0.00
1.1
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
4.9
—
47.4
—
0
8
0
8
0.00
0.00
0.0
1.9
—
1.2
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H8_STENOEXTCAN and mortality.

Females

Parameter HR [95% CI] p-value
H8_STENOEXTCAN 1.036 [0.77, 1.39] 0.814
Birth year 0.994 [0.99, 1.0] 0.2

During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 489 females with H8_STENOEXTCAN died.

Males

Parameter HR [95% CI] p-value
H8_STENOEXTCAN 1.014 [0.79, 1.31] 0.914
Birth year 0.982 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 868 males with H8_STENOEXTCAN died.

Mortality risk

Mortality risk for people of age

years, who have H8_STENOEXTCAN.

N-year risk Females Males
1 0.09% 0.156%
5 0.533% 1.027%
10 1.478% 2.479%
15 2.824% 4.708%
20 4.799% 7.887%

Relationships between endpoints

Index endpoint: H8_STENOEXTCAN – Acquired stenosis of external ear canal

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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