auditory system disease: Pathological processes of the ear, the hearing, and the equilibrium system of the body.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
359 |
4. Check minimum number of eventsNone |
359 |
5. Include endpointsNone |
359 |
6. Filter based on genotype QC (FinnGen only) |
349 |
Control definitions (FinnGen only)
- Control exclude
- H8_EXTERNAL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H61
- Name in latin
- Stenosis meatus acustici externi acquisita
Similar endpoints
↥List of similar endpoints to
Acquired stenosis of external ear canal
based on the number of shared cases.
Similar with more cases:
- Diseases of external ear
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1833 | 644 | 1188 |
| Only index persons | 1756 | 613 | 1143 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.02 | 0.03 |
| Only index persons | 0.04 | 0.02 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 57.68 | 56.60 | 58.25 |
| Only index persons | 57.63 | 56.73 | 58.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 349 | 105 | 244 |
| Unadjusted period prevalence (%) | 0.09 | 0.04 | 0.11 |
| Median age at first event (years) | 60.64 | 54.80 | 63.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 359
- Matched controls
- 3590
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H61.3
ICD-10 Finland
Acquired stenosis of external ear canal
4503599627370496.0
307.7
351
*
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
1330.5
171.9
154
*
UDC00
NOMESCO Finland
Ear microscopy
10.9
87.3
112
143
H61.8
ICD-10 Finland
Other specified disorders of external ear
211.6
82.0
82
5
H60.8
ICD-10 Finland
Other otitis externa
22.7
73.5
56
29
DFF00
NOMESCO Finland
Pure tone audiometry
8.4
71.8
116
193
H60.9
ICD-10 Finland
Otitis externa, unspecified
10.5
68.5
86
105
Z01.1
ICD-10 Finland
Examination of ears and hearing
6.2
54.8
123
280
H60.3
ICD-10 Finland
Other infective otitis externa
20.9
52.5
41
22
H61.2
ICD-10 Finland
Impacted cerumen
7.9
39.4
59
87
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
15.7
37.0
33
23
DBB00
NOMESCO Finland
Excision of lesion of external auditory canal
+∞
36.0
34
*
H60
ICD-10 Finland
Otitis externa
7.0
29.5
48
77
DC1AD
NOMESCO Finland
Temporalbone CT
38.8
25.7
32
9
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
3.5
24.9
110
398
H71
ICD-10 Finland
Cholesteatoma of middle ear
37.5
24.7
31
9
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic
9.5
23.6
29
33
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.1
14.9
72
268
R5120
NOMESCO Finland
Preparation of an aid
6.3
14.5
25
42
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
12.1
14.0
25
22
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
5.6
13.9
27
51
H65.3
ICD-10 Finland
Chronic mucoid otitis media
12.2
13.5
24
21
ZXE00
NOMESCO Finland
One hour or less
2.3
12.9
160
935
H81
ICPC
Excessive ear wax
2.6
12.5
86
385
Z97.4
ICD-10 Finland
Presence of external hearing-aid
4.3
12.4
33
82
H29
ICPC
Ear symptom/complaint other
3.0
11.7
57
212
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
11.7
151
889
DBD30
NOMESCO Finland
Correction of atresia of external auditory canal
+∞
11.5
11
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
12.4
11.5
20
17
H66.9
ICD-10 Finland
Otitis media, unspecified
4.3
11.4
30
74
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
5.1
11.1
24
50
TDA90
NOMESCO Finland
Removal wax from ear
12.5
11.0
19
16
H04
ICPC
Ear discharge
5.3
10.7
22
44
ZXD10
NOMESCO Finland
Scheduled procedure
2.1
10.0
150
922
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.3
9.8
86
427
WX402
NOMESCO Finland
General anaesthesia
2.3
9.7
91
464
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
30.9
9.5
12
*
H01
ICPC
Ear pain/earache
2.9
9.4
47
177
H92.0
ICD-10 Finland
Otalgia
3.9
9.4
28
76
DCD10
NOMESCO Finland
Tympanoplasty
37.7
9.1
11
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.0
9.0
42
152
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
13.0
8.9
15
12
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
51.3
8.7
10
*
ZXA00
NOMESCO Finland
Right side
2.1
8.7
112
645
H13
ICPC
Plugged feeling ear
2.2
8.5
86
451
H66.0
ICD-10 Finland
Acute suppurative otitis media
3.2
8.5
35
118
3805A
ICD-9 Finland
Disorders of external ear, Acquired stenosis of external ear canal
+∞
8.4
8
*
J01DB01
ATC
cefalexin; oral
2.4
8.2
306
2537
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
7.9
108
634
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
9.7
7.9
15
16
H65.2
ICD-10 Finland
Chronic serous otitis media
9.7
7.9
15
16
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
15.5
7.8
12
8
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
3.4
7.7
28
87
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic
7.0
7.7
18
27
H60.4
ICD-10 Finland
Cholesteatoma of external ear
81.7
7.4
8
*
4111
FHL
Ear canal extension
81.7
7.4
8
*
H70
ICPC
Otitis externa
7.1
7.4
17
25
DBD10
NOMESCO Finland
Reconstruction of external auditory canal
+∞
7.3
7
*
DBW99
NOMESCO Finland
Other operation on external auditory canal
+∞
7.3
7
*
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
16.1
7.3
11
7
D07AB02
ATC
hydrocortisone butyrate; topical
1.9
6.8
109
670
WX002
NOMESCO Finland
Sedation and analgesia
2.0
6.7
81
451
J01FA10
ATC
azithromycin; systemic
1.8
6.7
192
1407
S02CA02
ATC
flumetasone and antiinfectives; otic
3.1
6.7
28
95
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
2.9
6.6
32
118
H65.0
ICD-10 Finland
Acute serous otitis media
8.9
6.6
13
15
R01AD08
ATC
fluticasone; nasal
1.9
6.6
102
619
Q16.1
ICD-10 Finland
Congenital absence, atresia and stricture of auditory canal (external)
71.1
6.4
7
*
H62.0*A46
ICD-10 Finland
Otitis externa in erysipelas
71.1
6.4
7
*
ZXA10
NOMESCO Finland
Bilateral
2.0
6.4
74
405
J01DA08
ATC
[U] cefaclor
2.7
6.4
34
132
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
6.3
6
*
N03AF02
ATC
oxcarbazepine; oral
4.2
6.2
16
39
DFF15
NOMESCO Finland
Speech audiometry
3.1
6.1
26
89
ZXA05
NOMESCO Finland
Left side
1.9
6.1
94
569
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
55
326
1.81
3.71
3.3
3.6
—
—
—
0
0
19
77
2.55
3.35
1.7
1.5
—
—
—
0
0
320
2930
1.85
3.31
4.8
4.7
5.98
6.05
mmol/l
0.49
289
2675
209
1747
1.47
3.17
7.6
9.7
4.06
4.17
e9/l
0.33
182
1542
207
1735
1.46
3.04
2.5
2.7
—
—
—
0
0
341
3207
2.26
3.00
11.3
10.9
25.97
28.02
u/l
1.97
331
3118
328
3045
1.89
2.97
4.9
5.1
2.70
2.70
mmol/l
0.01
303
2809
66
448
1.58
2.70
1.2
1.3
17.70
32.79
iu/ml
1.62
21
145
176
1454
1.41
2.67
6.3
6.0
27.05
26.93
%
0.04
167
1382
309
2841
1.63
2.64
16.6
13.8
80.26
80.41
ml/min/173m2
0.05
266
2381
75
528
1.53
2.61
3.1
3.4
2.45
2.45
mmol/l
0.06
70
471
288
2613
1.52
2.54
18.1
17.8
14.68
15.10
%
0.65
281
2580
332
3118
1.86
2.53
18.3
17.4
139.63
139.64
mmol/l
0.02
324
3059
248
2195
1.42
2.42
3.8
4.1
11.79
11.62
mm/h
0.07
229
2032
172
1434
1.38
2.39
6.0
5.8
57.05
57.57
%
0.25
163
1366
12
46
2.66
2.38
1.2
1.3
—
—
—
0
0
321
2998
1.67
2.34
4.6
4.7
4.62
4.54
mmol/l
0.62
300
2781
347
3320
2.35
2.32
23.3
22.0
242.30
240.73
e9/l
0.19
338
3247
332
3130
1.81
2.32
18.5
17.5
3.99
4.00
mmol/l
0.15
325
3070
347
3321
2.34
2.30
23.4
22.0
41.11
40.69
%
0.72
330
3100
347
3323
2.32
2.26
23.3
22.0
4.55
4.55
e12/l
0.04
336
3237
347
3325
2.30
2.22
23.4
22.1
137.98
137.76
g/l
0.10
342
3285
238
2111
1.38
2.16
3.3
3.6
14.52
14.91
pmol/l
1.79
220
1890
19
95
2.06
2.15
1.5
1.5
—
—
—
0
0
52
354
1.55
2.11
2.6
2.2
13.73
13.52
nmol/l
0.06
41
319
5
10
5.05
2.07
5.0
7.1
—
—
—
0
0
318
2981
1.58
2.06
15.8
15.0
26.88
25.47
mg/l
0.28
260
2407
7
21
3.38
1.97
1.0
1.2
—
—
—
0
0
143
1186
1.34
1.96
2.6
2.7
137.27
157.77
ug/l
0.56
128
1089
107
850
1.37
1.93
1.7
1.7
1.41
1.40
mmol/l
0.03
85
713
7
22
3.22
1.89
1.7
2.1
13.19
13.26
%
—
7
22
316
2978
1.51
1.77
4.4
4.6
1.40
1.39
mmol/l
0.11
293
2745
258
2351
1.35
1.76
7.8
8.1
79.23
79.53
u/l
0.04
234
2219
207
1837
1.30
1.66
4.0
4.9
6.71
6.77
mmol/l
0.19
196
1723
286
2661
1.37
1.60
4.5
4.3
1.98
1.95
mu/l
0.11
258
2413
115
949
1.31
1.58
3.9
3.6
2.36
2.34
mmol/l
0.56
107
847
13
66
2.01
1.45
1.5
1.4
—
—
—
0
0
5
16
3.15
1.44
1.4
1.7
—
—
—
0
0
5
16
3.15
1.44
1.4
1.7
—
—
—
0
0
39
273
1.48
1.43
2.6
2.5
35.42
204.30
u/l
0.49
33
237
0
37
0.00
1.35
0.0
2.4
—
—
—
0
0
6
24
2.52
1.31
1.2
1.1
—
—
—
0
0
8
36
2.25
1.25
3.5
3.4
—
—
—
0
0
300
2842
1.34
1.24
5.7
6.1
39.59
40.35
mmol/mol
0.88
274
2657
88
722
1.29
1.24
2.0
2.1
2.65
3.08
mg/l
1.07
73
623
153
1347
1.24
1.18
4.9
6.0
1.21
1.21
mmol/l
0.26
143
1233
129
1116
1.24
1.17
3.0
3.1
—
—
—
0
0
55
426
1.34
1.17
1.3
1.3
23.56
13.06
u/ml
0.34
16
169
35
251
1.44
1.16
4.1
4.0
1.22
1.23
mmol/l
0.41
30
225
101
851
1.26
1.15
2.4
2.7
5028.52
5095.21
umol/l
0.00
86
744
70
563
1.30
1.15
3.6
4.0
343.34
345.81
ng/l
0.00
59
463
303
2883
1.33
1.15
4.1
4.1
1.42
1.33
mmol/l
1.21
282
2639
7
31
2.28
1.11
2.1
1.1
—
—
—
0
0
186
1685
1.22
1.06
5.3
4.8
2.00
2.22
ug/l
0.40
164
1522
115
993
1.23
1.05
3.1
3.0
0.71
0.73
ug/l
0.07
73
650
128
1118
1.23
1.05
2.4
2.3
73.54
74.86
nmol/l
0.20
111
993
11
60
1.86
1.04
5.1
4.0
50.55
56.63
%
0.41
11
60
5
22
2.29
1.03
1.6
1.7
85.00
85.68
umol/l
—
5
22
160
1433
1.21
1.01
2.6
2.7
—
—
—
0
0
163
1463
1.21
1.01
6.3
7.0
1.21
1.21
mmol/l
0.67
130
1244
180
1632
1.21
1.00
5.9
7.1
11.65
12.07
umol/l
0.20
171
1554
5
23
2.19
0.98
1.0
1.1
—
—
—
0
0
5
23
2.19
0.98
1.0
1.7
1.14
1.01
g/l
—
5
23
115
1001
1.22
0.96
3.1
3.1
8.75
8.20
mmol/l
0.60
88
833
86
726
1.24
0.96
2.4
2.4
—
—
—
0
0
17
109
1.59
0.95
2.1
1.8
—
—
—
0
0
77
643
1.25
0.95
1.3
1.8
1.00
1.44
mg/l
1.25
58
505
36
273
1.35
0.90
4.9
6.7
1.48
1.38
mmol/l
0.19
36
266
221
2055
1.20
0.89
2.9
3.4
42.52
53.68
u/l
2.32
194
1932
137
1225
1.19
0.85
1.9
1.9
92.84
94.03
pmol/l
0.10
63
667
10
58
1.74
0.80
3.6
3.3
3.06
4.62
e9/l
—
10
58
0
24
0.00
0.79
0.0
1.8
—
2.63
—
0
8
98
861
1.19
0.74
3.1
3.0
0.20
0.50
e6/l
1.86
69
656
16
109
1.49
0.72
1.6
1.9
3.01
2.92
g/l
0.11
16
98
7
40
1.76
0.71
1.1
1.3
—
—
—
0
0
9
57
1.59
0.71
1.0
1.3
—
—
—
0
0
9
57
1.59
0.71
1.0
1.3
—
—
—
0
0
27
204
1.35
0.71
2.0
1.6
—
—
—
0
0
9
145
0.61
0.71
2.1
2.1
1.38
3.46
ug/l
—
9
128
9
59
1.54
0.69
1.3
1.6
—
—
—
0
0
9
59
1.54
0.69
1.3
1.6
—
—
—
0
0
113
1013
1.17
0.67
4.0
3.7
8.83
8.23
mg/mmol
0.06
70
667
106
946
1.17
0.66
3.1
3.1
1364.71
1315.92
ng/l
0.05
93
808
12
78
1.56
0.66
1.1
2.1
9.49
11.23
mg/l
0.39
12
72
103
918
1.17
0.66
2.4
2.1
250.01
289.61
u/l
0.16
98
863
28
357
0.77
0.65
5.7
8.6
—
—
—
0
0
10
63
1.60
0.62
1.4
1.5
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
2.6
—
—
—
0
0
56
652
0.83
0.59
1.6
1.8
404.00
28440794.50
pmol/l
0.69
47
545
16
115
1.41
0.57
1.6
1.9
7.48
7.21
g/l
0.17
16
104
16
115
1.41
0.57
1.6
1.9
—
—
—
0
0
106
1165
0.87
0.55
3.5
3.6
—
—
—
0
0
148
1372
1.13
0.54
4.5
4.3
22.18
20.80
%
0.43
67
643
58
502
1.19
0.53
2.7
2.9
1.10
1.46
e6/l
0.25
26
289
29
233
1.27
0.53
1.3
1.3
—
—
—
0
0
10
145
0.68
0.51
1.1
1.2
—
—
—
0
0
57
499
1.17
0.46
1.9
1.9
—
—
—
0
0
17
129
1.33
0.46
2.1
2.0
409.55
667.04
ug/l
0.30
17
121
12
86
1.41
0.45
1.5
1.7
—
—
—
0
0
17
130
1.32
0.44
1.4
2.1
40.82
38.74
u/l
0.20
17
114
7
51
1.38
0.44
1.4
1.1
—
—
—
0
0
60
531
1.16
0.43
2.6
2.7
0.64
0.97
e6/l
0.67
29
314
14
105
1.35
0.41
2.3
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
0.60
—
0
10
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
16
123
1.31
0.41
2.4
2.8
—
—
—
0
0
32
377
0.83
0.40
4.8
4.6
31.93
31.27
%
0.13
27
263
25
205
1.24
0.40
2.6
3.1
2.68
1.71
mmol/l
0.51
18
155
16
204
0.77
0.40
5.9
3.6
121.50
129.46
g/l
0.52
16
199
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
2.5
—
103.63
—
0
19
5
36
1.39
0.38
1.4
1.6
—
—
—
0
0
5
36
1.39
0.38
1.4
1.6
—
—
—
0
0
5
36
1.39
0.38
1.0
1.1
—
—
—
0
0
5
36
1.39
0.38
1.4
1.6
—
—
—
0
0
21
170
1.25
0.38
1.2
1.3
91.56
48.94
au/ml
—
5
13
12
90
1.34
0.36
3.4
2.4
23.95
24.70
mmol/l
0.31
12
90
21
172
1.23
0.35
2.0
1.6
—
—
—
0
0
42
369
1.16
0.34
2.5
3.2
12.09
9.95
umol/l
0.15
33
329
6
45
1.34
0.34
1.0
1.2
—
—
—
0
0
6
45
1.34
0.34
1.2
1.1
2.06
1.50
g/l
—
6
39
48
430
1.13
0.31
3.0
2.4
22.11
22.83
%
0.17
41
367
22
260
0.84
0.30
1.6
1.8
—
—
—
0
0
7
56
1.25
0.29
1.3
1.4
—
91.20
—
0
10
21
177
1.20
0.28
1.9
2.8
0.04
0.18
e6/l
1.91
21
171
8
65
1.24
0.27
1.3
1.2
—
—
—
0
0
109
1029
1.09
0.27
2.8
3.9
29.93
33.57
u/l
1.06
102
978
6
82
0.73
0.24
1.2
1.3
—
—
—
0
0
131
1253
1.07
0.23
3.3
3.9
21.60
41.37
ng/l
3.71
91
927
33
296
1.13
0.22
2.7
2.5
0.23
0.21
g/l
0.84
33
271
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
17
145
1.18
0.21
1.1
1.2
59.60
164.79
iu/ml
—
5
52
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
156
1512
1.06
0.18
15.1
15.2
1.28
1.30
inr
0.10
53
447
7
60
1.17
0.18
1.9
1.7
—
—
—
0
0
7
62
1.13
0.17
1.0
1.2
—
1.07
—
0
6
77
810
0.94
0.17
3.8
3.7
0.00
0.01
estimate
0.69
36
276
57
535
1.08
0.17
1.8
1.7
1193.26
1202.16
nmol/l
0.02
42
410
14
161
0.86
0.15
5.9
3.5
23.96
24.97
mmol/l
0.56
14
155
10
84
1.20
0.14
1.6
1.7
—
—
—
0
0
10
84
1.20
0.14
2.0
1.9
—
—
—
0
0
10
84
1.20
0.14
1.1
1.3
—
—
—
0
0
8
97
0.82
0.14
2.1
1.7
—
—
—
0
0
63
599
1.06
0.14
1.2
1.2
6.42
1.16
u/ml
0.52
12
169
145
1489
0.96
0.14
3.4
3.5
0.00
0.00
estimate
-0.00
33
276
8
100
0.80
0.13
5.6
3.1
—
1.27
—
0
10
10
85
1.18
0.12
1.3
1.7
—
—
—
0
0
21
191
1.11
0.12
1.2
1.7
—
—
—
0
0
22
201
1.10
0.11
4.8
4.2
126.64
84.84
ng/l
0.65
14
185
7
66
1.06
0.08
1.0
1.2
—
—
—
0
0
133
1305
1.03
0.08
5.8
5.5
34.80
35.34
g/l
0.48
120
1226
6
75
0.80
0.07
1.2
1.1
—
—
—
0
0
8
74
1.08
0.07
1.6
1.8
—
—
—
0
0
49
509
0.96
0.07
2.1
2.2
31.13
29.70
s
0.89
49
495
7
83
0.84
0.07
2.4
1.4
—
—
—
0
0
7
83
0.84
0.07
2.3
1.4
—
—
—
0
0
102
998
1.03
0.07
2.8
2.8
52.98
63.38
u/l
1.16
87
929
9
88
1.02
0.07
1.1
1.2
—
—
—
0
0
148
1468
1.01
0.02
3.2
3.5
0.00
0.00
estimate
0.50
37
308
73
740
0.98
0.02
1.6
1.6
20.71
20.25
nmol/l
0.10
64
630
20
194
1.03
0.00
1.3
1.4
—
—
—
0
0
26
254
1.03
0.00
2.0
2.7
65.88
66.15
g/l
0.07
26
236
37
364
1.02
0.00
1.9
1.9
—
—
—
0
0
42
422
0.99
0.00
1.4
1.4
—
—
—
0
0
13
131
0.99
0.00
1.0
1.0
—
—
—
0
0
24
239
1.00
0.00
2.0
2.5
59.29
64.32
ml/min/173m2
0.35
14
101
29
289
1.00
0.00
4.1
4.0
6.09
5.81
kpa
0.57
29
277
147
1467
1.00
0.00
4.4
4.6
0.00
0.00
estimate
-0.00
37
292
21
215
0.98
0.00
1.2
1.8
—
—
—
0
0
36
356
1.01
0.00
1.9
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
7
73
0.96
0.00
1.3
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
9
0.00
0.00
0.0
2.2
—
123.11
—
0
9
6
69
0.87
0.00
1.5
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
57.54
—
0
5
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
9
94
0.96
-0.00
1.1
1.6
—
—
—
0
0
9
90
1.00
-0.00
1.1
1.2
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
8
0.00
-0.00
0.0
1.0
—
129.50
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
60
1.00
-0.00
1.5
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
55
0.91
-0.00
1.6
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
26.28
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.6
—
40.57
—
0
7
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
90
1.00
-0.00
1.3
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
1.27
—
0
8
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_STENOEXTCAN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_STENOEXTCAN | 1.036 [0.77, 1.39] | 0.814 |
| Birth year | 0.994 [0.99, 1.0] | 0.2 |
During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 489 females with H8_STENOEXTCAN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_STENOEXTCAN | 1.014 [0.79, 1.31] | 0.914 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 868 males with H8_STENOEXTCAN died.
Mortality risk
Mortality risk for people of age
years, who have H8_STENOEXTCAN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.09% | 0.156% |
| 5 | 0.533% | 1.027% |
| 10 | 1.478% | 2.479% |
| 15 | 2.824% | 4.708% |
| 20 | 4.799% | 7.887% |
Relationships between endpoints
↥Index endpoint: H8_STENOEXTCAN – Acquired stenosis of external ear canal
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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