brain aneurysm: A congenital or acquired aneurysm within the cranium.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
288 |
4. Check minimum number of eventsNone |
288 |
5. Include endpointsNone |
288 |
6. Filter based on genotype QC (FinnGen only) |
274 |
Control definitions (FinnGen only)
- Control exclude
- I9_CEREBVASC
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- I67
- Name in latin
- Dissectio arteriae cerebralis sine ruptura
Similar endpoints
↥List of similar endpoints to
Dissection of cerebral arteries, nonruptured
based on the number of shared cases.
Similar with more cases:
- Cerebrovascular diseases
- Neurological diseases, wide definition
- Cardiovascular diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1673 | 729 | 931 |
| Only index persons | 1553 | 683 | 870 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 52.52 | 52.32 | 52.80 |
| Only index persons | 51.96 | 51.56 | 52.28 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 274 | 149 | 125 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.06 |
| Median age at first event (years) | 50.80 | 47.83 | 54.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 288
- Matched controls
- 2880
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I67.0
ICD-10 Finland
Dissection of cerebral arteries, nonruptured
+∞
307.7
287
*
B01AA03
ATC
warfarin; systemic
14.6
120.0
156
216
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
42.1
108.7
68
21
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
505.9
80.1
76
*
AA1AD
NOMESCO Finland
CT of head and brain
8.2
72.2
156
364
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
815.0
67.9
64
*
I63.2
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
+∞
47.2
44
*
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
+∞
45.0
42
*
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
16.0
43.3
39
28
XA800
NOMESCO Finland
Neuropsychological investigation
11.3
41.5
47
49
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
+∞
38.4
36
*
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
405.5
36.9
36
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
8.6
31.9
44
59
G90.2
ICD-10 Finland
Horner syndrome
335.8
30.4
30
*
B01AC04
ATC
clopidogrel; oral
5.0
27.3
70
174
PA6AD
NOMESCO Finland
CT of neck arteries
27.2
26.4
36
15
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
10.7
26.3
30
31
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
+∞
22.2
21
*
R51.80
ICD-10 Finland
Headache
3.7
21.2
84
285
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.0
20.3
48
110
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
+∞
20.0
19
*
PA6BG
NOMESCO Finland
MRI examination of neck vasculature with high intensity magnet
78.9
20.0
22
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.9
19.6
48
113
K90
ICPC
Stroke/cerebrovascular accident
75.1
19.0
21
*
PA6CG
NOMESCO Finland
Extensive MRI examination of neck vasculature with high intensity magnet
202.6
18.8
19
*
I67.9
ICD-10 Finland
Cerebrovascular disease, unspecified
56.4
18.2
21
*
XF400
NOMESCO Finland
ECG with 12 standard connections
3.6
16.9
65
214
PA2BG
NOMESCO Finland
MRI examination of vessels in the head with high intensity magnet
+∞
16.8
16
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.8
16.2
57
176
I65.0
ICD-10 Finland
Occlusion and stenosis of vertebral artery
+∞
15.8
15
*
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
90.1
15.7
17
*
C10AA05
ATC
atorvastatin; oral
2.7
15.4
131
674
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
17.3
13.7
21
13
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
36.0
13.7
17
5
B01AB05
ATC
enoxaparin; parenteral
2.6
13.4
113
571
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
18.4
12.7
19
11
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.8
12.3
40
116
R42
ICD-10 Finland
Dizziness and giddiness
2.8
12.1
74
316
H53.1
ICD-10 Finland
Subjective visual disturbances
4.0
11.3
34
93
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
+∞
10.5
10
*
I72.0
ICD-10 Finland
Aneurysm and dissection of carotid artery
+∞
10.5
10
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
10.4
77
359
R4150
NOMESCO Finland
Neuropsychological rehabilitation
24.4
10.3
14
6
R4120
NOMESCO Finland
Occupational therapy
4.0
10.3
31
85
PA7BD
NOMESCO Finland
CT angiography of neck and brain
17.5
10.0
15
9
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
9.3
10.0
20
23
PA7CC
NOMESCO Finland
Very extensive angiography of arteries of neck and brain
57.0
9.7
11
*
N03AF02
ATC
oxcarbazepine; oral
5.4
9.5
19
37
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
+∞
9.4
9
*
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
+∞
9.4
9
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.4
8.9
23
56
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
8.1
8.8
19
25
K99
ICPC
Cardiovascular disease other
11.2
8.4
15
14
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
+∞
8.4
8
*
G46.4*I67.9
ICD-10 Finland
Cerebellar stroke syndrome
+∞
8.4
8
*
I67.8
ICD-10 Finland
Other specified cerebrovascular diseases
+∞
8.4
8
*
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
+∞
8.4
8
*
H53.4
ICD-10 Finland
Visual field defects
15.1
8.3
13
9
Z2445
NOMESCO Finland
Psychologist
4.2
8.2
22
55
C09AA05
ATC
ramipril; oral
2.3
7.8
74
382
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
6.5
7.7
19
31
ZXA05
NOMESCO Finland
Left side
2.2
7.5
76
402
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
8.7
7.4
15
18
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.5
7.3
52
235
PA2AC
NOMESCO Finland
Cerebral angiography with X-ray
+∞
7.3
7
*
I63.5
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
+∞
7.3
7
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
7.3
128
830
PA6AG
NOMESCO Finland
Limited MRI examination of neck vasculature with high intensity magnet
30.9
7.2
9
*
R4110
NOMESCO Finland
Physiotherapy
2.1
7.1
89
510
I10
ICD-10 Finland
Essential (primary) hypertension
1.9
6.9
163
1162
R51
ICD-10 Finland
Headache
3.5
6.7
23
69
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.3
6.6
59
295
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
6.6
112
712
R20.2
ICD-10 Finland
Paraesthesia of skin
3.0
6.3
28
99
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
3.1
6.3
26
88
I63.1
ICD-10 Finland
Cerebral infarction due to embolism of precerebral arteries
+∞
6.3
6
*
I63.8
ICD-10 Finland
Other cerebral infarction
+∞
6.3
6
*
Z2446
NOMESCO Finland
Social worker
3.1
6.1
26
90
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
110
268
6.02
45.81
1.9
1.8
29.08
29.58
s
0.45
105
258
144
593
3.86
28.34
2.3
1.9
157.43
168.83
u/l
0.12
137
550
162
928
2.70
15.33
18.5
10.9
1.56
1.19
inr
3.11
41
281
61
213
3.36
14.30
7.3
8.0
0.98
1.31
mmol/l
0.27
44
179
60
213
3.30
13.66
7.6
7.9
13.65
12.19
kpa
0.84
54
206
60
213
3.30
13.66
7.6
7.9
5.14
5.18
kpa
0.13
54
204
195
1272
2.65
13.45
5.9
4.2
6.15
6.61
mmol/l
4.78
184
1179
78
380
2.44
9.53
3.7
3.3
364.18
241.21
ng/l
0.27
51
274
36
125
3.15
8.36
7.4
9.4
0.69
0.70
%
0.03
36
125
12
8
15.58
7.78
1.4
2.4
—
—
—
0
0
34
126
2.93
7.05
7.4
9.2
1.64
1.45
%
0.23
34
126
135
911
1.91
6.65
7.7
5.2
1.20
1.21
mmol/l
1.40
123
841
146
1011
1.90
6.64
8.5
6.1
1.20
1.21
mmol/l
1.21
125
861
15
25
6.27
6.08
1.1
1.1
3.29
2.10
u/ml
—
7
10
52
258
2.24
5.91
7.6
6.6
105.58
103.97
mmol/l
1.73
52
258
39
173
2.45
5.70
3.3
2.6
68.13
74.97
ml/min/173m2
0.33
15
72
64
350
2.07
5.68
2.9
2.4
1.34
0.98
e6/l
0.35
33
186
272
2417
3.26
5.51
19.4
13.0
3.95
3.96
mmol/l
0.41
266
2367
30
119
2.70
5.49
9.5
6.9
24.28
24.41
mmol/l
0.08
25
114
271
2406
3.14
5.45
19.5
12.9
139.76
139.74
mmol/l
0.06
266
2360
17
48
3.70
5.41
1.6
1.1
38.67
10.92
e6/l
0.35
12
37
111
747
1.79
5.21
3.7
2.8
—
—
—
0
0
59
324
2.03
5.15
3.3
2.6
3.38
3.05
e6/l
0.05
29
162
76
459
1.89
5.03
2.0
2.0
2.89
3.17
mg/l
0.45
68
397
267
2372
2.72
4.98
17.4
11.8
21.11
22.52
mg/l
0.27
216
1820
88
582
1.74
4.24
3.4
2.7
0.33
0.27
e6/l
0.17
64
424
205
1694
1.73
4.23
4.3
3.9
9.80
10.28
mm/h
0.20
200
1576
10
18
5.71
4.01
1.1
1.1
100.60
90.22
%
—
10
18
75
487
1.73
3.82
1.7
1.7
0.74
1.06
mg/l
0.98
53
380
41
222
1.99
3.69
2.2
1.6
—
—
—
0
0
16
56
2.97
3.69
1.7
2.3
0.43
1.29
g/l
0.64
16
51
77
510
1.70
3.63
2.8
2.1
—
—
—
0
0
40
217
1.98
3.59
2.0
1.6
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
7
9
7.94
3.58
1.0
1.0
115.86
154.67
%
—
7
9
8
13
6.29
3.52
1.1
1.0
—
—
—
0
0
108
790
1.59
3.41
3.4
3.4
43.58
42.07
ng/l
0.02
63
500
46
267
1.86
3.38
3.3
2.1
21.12
23.63
%
0.64
40
236
11
29
3.90
3.22
1.1
1.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
11
6.49
3.20
1.1
1.4
—
—
—
0
0
52
321
1.76
3.13
2.7
3.0
0.86
0.82
mmol/l
0.80
47
308
132
1032
1.52
3.00
3.3
2.5
—
—
—
0
0
274
2555
2.49
2.96
19.3
13.5
80.24
75.72
umol/l
0.73
274
2555
15
58
2.67
2.92
1.7
2.0
8.71
10.20
g/l
0.70
15
53
63
419
1.64
2.88
1.3
1.3
38.95
31.40
iu/ml
0.25
22
143
6
9
6.78
2.88
1.2
1.2
—
—
—
0
0
42
250
1.80
2.85
8.4
4.8
1.03
1.01
mmol/l
0.15
37
232
8
18
4.54
2.81
2.3
1.8
—
—
—
0
0
15
60
2.58
2.75
5.7
3.3
3.81
4.02
mmol/l
0.94
15
60
16
67
2.47
2.68
1.7
1.9
—
—
—
0
0
240
2164
1.65
2.61
4.9
4.4
1.74
2.39
mu/l
0.62
228
1999
252
2312
1.72
2.42
4.1
3.7
1.25
1.32
mmol/l
0.83
240
2148
49
321
1.63
2.37
2.1
1.7
—
—
—
0
0
26
141
1.93
2.36
2.3
2.6
64.57
68.07
g/l
1.85
26
129
258
2389
1.77
2.31
4.6
4.1
1.41
1.46
mmol/l
1.12
246
2231
104
810
1.44
2.27
2.0
1.8
90.13
95.73
pmol/l
0.64
55
428
5
9
5.63
2.22
1.2
1.3
—
—
—
0
0
280
2689
2.49
2.14
26.3
17.5
40.51
40.79
%
0.28
262
2554
280
2687
2.51
2.14
26.0
17.5
247.50
252.39
e9/l
0.66
273
2637
193
1693
1.42
2.09
3.4
2.9
44.64
47.89
u/l
0.15
182
1614
199
1761
1.42
2.01
8.0
7.3
71.51
77.11
u/l
2.04
189
1668
280
2691
2.46
2.01
26.1
17.5
4.56
4.55
e12/l
0.03
270
2632
112
901
1.40
2.00
5.7
4.5
35.84
36.42
g/l
0.56
105
849
257
2396
1.67
1.99
4.7
4.2
4.44
4.78
mmol/l
5.64
247
2253
39
255
1.61
1.92
9.2
6.5
—
—
—
0
0
238
2186
1.51
1.90
5.4
5.2
38.11
39.38
mmol/mol
1.55
231
2068
244
2254
1.54
1.89
14.7
10.9
84.45
85.04
ml/min/173m2
0.16
207
1877
260
2438
1.68
1.87
5.3
4.5
2.58
2.86
mmol/l
4.68
253
2275
139
1177
1.35
1.74
5.6
6.2
10.75
11.07
umol/l
0.19
134
1127
56
406
1.47
1.74
1.4
1.3
4.49
10.51
u/ml
0.73
15
173
7
24
2.96
1.73
1.1
1.1
—
—
—
0
0
5
13
3.89
1.72
1.0
1.3
118.60
101.92
%
—
5
13
5
13
3.89
1.72
1.0
1.4
0.89
1.19
g/l
—
5
13
28
173
1.69
1.71
6.4
3.0
2.54
2.07
mmol/l
0.26
21
141
16
83
1.98
1.68
7.7
2.9
23.94
24.41
mmol/l
0.21
16
83
153
1321
1.34
1.66
9.4
9.3
4.16
3.98
e9/l
0.38
136
1168
5
14
3.61
1.62
1.6
2.8
—
—
—
0
0
14
70
2.05
1.62
1.1
2.6
—
—
—
0
0
88
707
1.35
1.52
2.8
3.3
2.34
2.35
mmol/l
0.30
82
640
13
65
2.05
1.51
1.0
1.1
—
—
—
0
0
13
65
2.05
1.51
1.0
1.1
—
—
—
0
0
129
1101
1.31
1.46
3.9
3.2
0.12
0.00
estimate
0.46
17
232
11
52
2.16
1.46
1.2
1.2
—
—
—
0
0
5
16
3.16
1.44
1.4
1.4
—
—
—
0
0
72
567
1.36
1.41
3.5
3.0
1769.84
905.88
ng/l
0.75
64
470
130
1115
1.30
1.41
3.8
3.2
0.00
0.01
estimate
0.50
15
214
73
582
1.34
1.32
2.7
2.4
12035.63
5960.12
umol/l
0.31
67
525
128
1103
1.29
1.32
5.2
4.3
0.00
0.00
estimate
-0.00
15
220
5
18
2.81
1.29
9.0
6.5
14.62
11.25
mg/l
—
5
18
9
45
2.03
1.24
1.8
1.9
—
—
—
0
0
86
708
1.31
1.24
2.2
2.5
59.78
63.21
u/l
0.17
78
655
194
1772
1.29
1.22
4.1
3.8
14.62
14.62
pmol/l
0.00
186
1633
96
805
1.29
1.20
3.4
3.2
33.03
31.74
u/l
0.14
91
767
12
64
1.91
1.20
2.7
1.3
—
—
—
0
0
58
456
1.34
1.15
1.5
1.4
18.09
21.23
nmol/l
1.04
52
398
7
31
2.29
1.11
1.0
1.2
—
—
—
0
0
7
31
2.29
1.11
3.3
1.4
—
111.00
—
0
7
19
288
0.64
1.10
1.7
1.7
—
—
—
0
0
10
52
1.96
1.07
1.7
1.4
—
—
—
0
0
49
380
1.35
1.06
1.5
1.4
—
—
—
0
0
18
114
1.62
1.05
2.3
1.9
—
—
—
0
0
11
60
1.87
1.04
2.1
2.4
1.52
1.38
mg/l
0.18
11
55
21
139
1.55
1.03
2.4
1.9
—
—
—
0
0
242
2299
1.33
0.99
4.6
4.1
5.80
5.87
mmol/l
0.54
230
2131
6
29
2.09
0.90
2.8
4.4
—
996.71
—
0
7
6
29
2.09
0.90
1.2
1.1
—
—
—
0
0
6
29
2.09
0.90
1.2
1.1
—
—
—
0
0
13
81
1.63
0.82
1.2
1.4
157.88
259.55
miu/ml
—
8
45
6
32
1.89
0.82
1.8
1.5
—
—
—
0
0
0
24
0.00
0.79
0.0
1.4
—
—
—
0
0
37
289
1.32
0.79
2.3
2.0
—
—
—
0
0
73
626
1.22
0.74
1.4
1.7
1.29
1.43
mmol/l
0.98
62
542
7
38
1.86
0.74
1.7
1.4
—
—
—
0
0
7
41
1.72
0.70
4.1
2.6
24.37
24.94
mmol/l
—
7
41
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
10
64
1.58
0.59
1.4
1.5
—
—
—
0
0
6
36
1.68
0.57
1.3
1.2
—
—
—
0
0
6
36
1.68
0.57
1.8
1.8
13.50
13.16
%
—
6
36
55
473
1.20
0.55
1.4
1.5
—
—
—
0
0
17
125
1.38
0.55
1.1
1.3
—
—
—
0
0
23
178
1.32
0.55
1.1
1.2
123.78
161.01
iu/ml
—
9
80
9
61
1.49
0.54
2.9
1.9
—
—
—
0
0
6
39
1.55
0.53
1.2
1.1
—
—
—
0
0
6
39
1.55
0.53
1.2
1.1
—
—
—
0
0
31
253
1.25
0.51
2.1
1.9
—
—
—
0
0
7
47
1.50
0.48
1.0
1.9
—
—
—
0
0
48
415
1.19
0.46
1.5
1.8
411.16
425.09
pmol/l
0.19
43
361
5
81
0.61
0.46
3.4
3.6
7.80
1452.88
u/ml
—
5
67
19
148
1.30
0.45
1.3
1.5
—
—
—
0
0
14
105
1.35
0.42
2.9
1.6
—
—
—
0
0
57
506
1.16
0.41
1.2
1.3
3.20
2.09
u/ml
0.16
14
150
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
7
104
0.67
0.40
1.9
1.5
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
5
37
1.36
0.37
1.2
1.2
—
—
—
0
0
68
617
1.13
0.36
4.0
4.1
19.66
21.41
%
0.39
25
270
94
872
1.12
0.35
4.2
3.2
—
—
—
0
0
31
265
1.19
0.35
1.7
2.2
6.67
8.19
umol/l
0.44
24
227
69
630
1.13
0.34
3.5
3.8
7.48
9.67
mg/mmol
0.24
43
403
6
45
1.34
0.34
1.8
1.5
—
—
—
0
0
10
74
1.36
0.32
1.1
1.4
—
—
—
0
0
39
344
1.15
0.31
1.5
1.6
1213.06
1145.57
nmol/l
0.19
34
269
25
212
1.20
0.31
2.9
3.1
—
—
—
0
0
8
108
0.73
0.29
4.6
1.7
—
—
—
0
0
6
82
0.73
0.24
2.2
1.9
—
—
—
0
0
171
1655
1.08
0.24
4.0
3.2
—
—
—
0
0
5
39
1.29
0.23
1.2
1.3
30.32
15.86
u/l
—
5
34
5
39
1.29
0.23
1.4
1.1
—
—
—
0
0
5
40
1.25
0.22
2.4
1.8
—
—
—
0
0
5
40
1.25
0.22
2.4
1.8
—
—
—
0
0
5
42
1.19
0.21
4.8
2.4
129.80
132.86
g/l
—
5
28
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
5
43
1.17
0.21
2.0
3.3
15.20
35.64
u/ml
—
5
43
62
580
1.09
0.20
5.0
3.5
0.00
0.02
estimate
0.68
15
217
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
2.0
—
—
—
0
0
94
898
1.07
0.18
2.2
2.3
81.53
75.47
nmol/l
0.82
88
819
7
59
1.19
0.18
2.0
1.7
—
—
—
0
0
7
63
1.11
0.17
1.7
2.1
142.29
261.79
ug/l
—
7
57
7
63
1.11
0.17
1.9
1.6
—
—
—
0
0
8
70
1.15
0.16
1.5
1.2
—
—
—
0
0
17
193
0.87
0.16
1.7
2.4
0.24
0.22
g/l
0.48
17
181
14
158
0.88
0.12
1.5
3.7
1.23
1.23
mmol/l
0.06
14
141
6
57
1.05
0.08
2.0
1.4
—
—
—
0
0
6
57
1.05
0.08
2.0
1.4
—
—
—
0
0
6
57
1.05
0.08
2.0
1.4
—
—
—
0
0
6
58
1.04
0.08
2.0
1.6
—
—
—
0
0
10
88
1.14
0.08
1.3
1.4
—
—
—
0
0
46
475
0.96
0.05
2.5
2.8
0.61
0.71
ug/l
0.45
22
296
79
774
1.03
0.05
4.3
4.4
1.51
2.27
ug/l
1.03
71
693
33
339
0.97
0.02
1.2
2.0
1.70
1.40
%
0.55
28
306
13
133
0.98
0.00
2.7
2.5
25.73
49.62
u/ml
0.61
13
128
11
106
1.04
0.00
3.2
1.3
—
—
—
0
0
12
116
1.04
0.00
1.1
1.1
—
—
—
0
0
6
63
0.95
0.00
1.0
1.3
—
16.97
—
0
11
7
69
1.01
-0.00
1.1
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
97.80
—
0
5
0
7
0.00
-0.00
0.0
2.6
—
222.71
—
0
7
5
51
0.98
-0.00
1.6
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
7.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
5
53
0.94
-0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint I9_DISCER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_DISCER | 1.628 [1.22, 2.17] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.506 |
During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 624 females with I9_DISCER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_DISCER | 1.389 [1.11, 1.74] | 0.004 |
| Birth year | 0.99 [0.98, 1.0] | 0.035 |
During the follow-up period (1.1.1998 — 31.12.2019), 128 out of 787 males with I9_DISCER died.
Mortality risk
Mortality risk for people of age
years, who have I9_DISCER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.099% | 0.298% |
| 5 | 0.878% | 1.694% |
| 10 | 2.544% | 4.33% |
| 15 | 4.874% | 8.115% |
| 20 | 8.809% | 14.239% |
Relationships between endpoints
↥Index endpoint: I9_DISCER – Dissection of cerebral arteries, nonruptured
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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