recurrent pneumonia: recurrent pneumonia due to nontuberculous mycobacterium infections
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
434 |
4. Check minimum number of eventsNone |
434 |
5. Include endpointsNone |
434 |
6. Filter based on genotype QC (FinnGen only) |
420 |
Control definitions (FinnGen only)
- Control exclude
- ASTHMA_PNEUMONIA
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- A31
- Name in latin
- Infectio pulmonalis mycobacterialis
Similar endpoints
↥List of similar endpoints to
Atypical mycobacterium lung infection
based on the number of shared cases.
Similar with more cases:
- Pneumonias (Asthma/COPD co-morbidities)
- COPD/asthma/ILD related pneumonia or pneumonia derived septicaemia
- COPD/asthma related pneumonia or pneumonia derived septicaemia
- COPD/asthma related infections
- COPD/asthma/ILD related infections
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3018 | 1576 | 1387 |
| Only index persons | 2203 | 1277 | 926 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.04 |
| Only index persons | 0.04 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 68.38 | 71.46 | 64.83 |
| Only index persons | 67.81 | 70.61 | 63.93 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 420 | 236 | 184 |
| Unadjusted period prevalence (%) | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | 68.37 | 67.78 | 69.12 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 434
- Matched controls
- 4340
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A31.0
ICD-10 Finland
Pulmonary mycobacterial infection
4503599627370496.0
307.7
412
*
J47
ICD-10 Finland
Bronchiectasis
71.8
269.2
151
32
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
27.2
210.8
163
94
UGC12
NOMESCO Finland
Flexible bronchoscopy
19.9
209.8
205
187
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
15.3
181.3
215
261
R03BB04
ATC
tiotropium bromide; inhalant
15.0
169.2
194
222
TGC00
NOMESCO Finland
Bronchial lavation
22.6
118.2
92
51
R03AK06
ATC
salmeterol and fluticasone; inhalant
9.4
113.7
184
315
J01MA14
ATC
moxifloxacin; systemic
11.2
112.1
143
182
J18.9
ICD-10 Finland
Pneumonia, unspecified
8.6
111.9
280
760
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
8.3
108.0
212
446
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
14.2
96.6
97
86
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
17.0
90.2
80
57
GD1AD
NOMESCO Finland
Thorax CT examination
11.1
89.2
108
126
R03DA04
ATC
theophylline; systemic, rectal
11.6
86.6
100
109
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
7.7
79.8
140
253
J45.9
ICD-10 Finland
Asthma, unspecified
6.7
79.2
173
390
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
7.6
73.1
126
222
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
16.3
69.5
62
44
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
9.0
69.0
97
135
J01MA12
ATC
levofloxacin; systemic
5.6
66.6
185
509
J45.0
ICD-10 Finland
Predominantly allergic asthma
9.0
66.2
92
126
R03AC12
ATC
salmeterol; inhalant
10.4
66.0
80
92
R04.2
ICD-10 Finland
Haemoptysis
12.3
65.6
70
67
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
13.7
64.9
64
54
J45.1
ICD-10 Finland
Nonallergic asthma
8.6
60.8
87
123
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.7
49.3
314
1550
R03DC03
ATC
montelukast; oral
5.1
48.4
128
328
R03AC02
ATC
salbutamol; inhalant
4.8
48.0
326
1673
R03AC03
ATC
terbutaline; inhalant
5.1
44.5
114
283
R03BA05
ATC
fluticasone; inhalant
4.5
44.2
141
417
R81
ICPC
Pneumonia
10.6
44.2
51
54
J46
ICD-10 Finland
Status asthmaticus
18.9
43.3
35
20
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
7.6
42.9
66
100
H02AB06
ATC
prednisolone; systemic
4.0
41.8
294
1490
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
7.7
41.5
63
94
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
3.9
39.9
293
1510
A31.9
ICD-10 Finland
Mycobacterial infection, unspecified
424.0
39.7
39
*
R03AK08
ATC
formoterol and beclometasone; inhalant
8.9
38.8
51
64
R03AK03
ATC
[U] fenoterol and ipratropium bromide
6.5
38.7
69
122
J96.1
ICD-10 Finland
Chronic respiratory failure
12.1
37.6
39
35
H02AB04
ATC
methylprednisolone; systemic
4.2
36.1
119
356
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
3.7
34.7
148
528
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
7.7
32.9
49
71
R03BB01
ATC
ipratropium bromide; inhalant
6.3
32.7
59
105
R03BA01
ATC
beclometasone; inhalant
4.1
31.8
107
322
R03AC13
ATC
formoterol; inhalant
6.6
31.7
55
94
H02AB07
ATC
prednisone; oral
3.9
30.6
109
341
J45.8
ICD-10 Finland
Mixed asthma
11.4
29.0
31
29
XG410
NOMESCO Finland
Flow-volume spirometry
6.9
28.9
47
75
A15.0
ICD-10 Finland
Tuberculosis of lung, confirmed by sputum microscopy with or without culture
+∞
28.4
27
*
R95
ICPC
Chron obstructive pulmonary disease
8.7
28.2
37
46
R03BA02
ATC
budesonide; inhalant
3.5
27.5
118
416
J45
ICD-10 Finland
Asthma
4.5
25.7
69
174
J01FA06
ATC
roxithromycin; oral
2.8
25.2
231
1241
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
7.3
25.0
38
56
TDM10
NOMESCO Finland
Puncture of maxillary antrum
7.5
24.1
36
52
J01FA09
ATC
clarithromycin; systemic
2.8
21.9
166
797
3101A
ICD-9 Finland
Specific nonpsychotic mental disorders following organic brain damage, Organic personality syndrome
+∞
21.0
20
*
R02
ICPC
Shortness of breath/dyspnoea
3.3
20.6
89
311
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.5
20.3
79
258
B44.1
ICD-10 Finland
Other pulmonary aspergillosis
209.1
19.7
20
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.9
19.5
62
176
J01AA02
ATC
doxycycline; systemic
3.4
19.0
372
2772
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
18.9
109
449
UDH02
NOMESCO Finland
Rhinopharyngoscopy
4.3
18.8
52
133
WW200
NOMESCO Finland
Immunization
7.5
18.4
27
38
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
5.3
18.4
39
80
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
4.3
18.4
51
131
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
5.7
18.1
35
66
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
5.1
17.9
39
82
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
22.0
17.5
25
12
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
4.5
17.4
45
109
R03AK07
ATC
formoterol and budesonide; inhalant
2.8
17.1
100
413
R03BA08
ATC
ciclesonide; inhalant
3.8
16.7
54
155
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
17.6
16.3
25
15
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
7.5
15.8
23
32
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
15.5
203
1210
R03AK11
ATC
formoterol and fluticasone; inhalant
7.3
15.4
23
33
R50.9
ICD-10 Finland
Fever, unspecified
2.8
14.9
90
376
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
6.5
14.3
24
39
R03AL08
ATC
vilanterol, umeclidinium bromide and fluticasone furoate; inhalant
10.2
13.4
26
27
R01AD08
ATC
fluticasone; nasal
2.3
13.2
130
679
R05
ICD-10 Finland
Cough
2.4
13.2
114
563
A03
ICPC
Fever
2.7
13.1
82
348
J41.1
ICD-10 Finland
Mucopurulent chronic bronchitis
51.6
12.9
15
*
R03DC01
ATC
zafirlukast; oral
11.0
12.9
24
23
J01FA10
ATC
azithromycin; systemic
2.1
12.9
243
1635
R06.0
ICD-10 Finland
Dyspnoea
2.2
12.8
149
832
A02BC02
ATC
pantoprazole; systemic
2.3
12.7
319
2388
R05
ICPC
Cough
2.3
12.7
124
645
A15.1
ICD-10 Finland
Tuberculosis of lung, confirmed by culture only
+∞
12.6
12
*
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.2
12.5
137
746
J01GB01
ATC
tobramycin; inhalant, parenteral
133.7
12.5
13
*
J01FA15
ATC
telithromycin; oral
3.1
12.1
54
190
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
12.1
161
945
J40
ICD-10 Finland
Bronchitis, not specified as acute or chronic
5.6
11.9
23
43
R01AD09
ATC
mometasone; nasal
2.1
11.9
200
1277
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.4
11.8
45
144
SPAT1017
SPAT
Examination of colour vision
66.8
11.7
13
*
348
Kela drug reimbursment
Roflumilast
123.1
11.5
12
*
M05BA04
ATC
alendronic acid; oral
2.7
11.5
66
267
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.2
11.4
31
78
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.5
11.4
41
126
R96
ICPC
Asthma
3.0
11.3
54
197
WX892
NOMESCO Finland
Monitored bed care
3.2
11.3
47
158
J20
ICD-10 Finland
Acute bronchitis
2.8
11.2
59
228
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
5.9
11.1
20
35
XQ800
NOMESCO Finland
Prick test
3.4
11.0
41
129
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
5.6
11.0
21
39
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
14.7
10.6
17
12
SPAT1255
SPAT
Intravenous administration of medicine
3.2
10.6
43
143
R03DX07
ATC
roflumilast; oral
112.6
10.5
11
*
A31.80
ICD-10 Finland
Oral infection caused by Mycobacterium intracellulare
112.6
10.5
11
*
A31.89
ICD-10 Finland
Other mycobacterial infections
112.6
10.5
11
*
A16.0
ICD-10 Finland
Tuberculosis of lung, bacteriologically and histologically negative
33.4
10.4
13
*
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
4.9
10.4
23
49
J01CA04
ATC
amoxicillin; systemic
2.2
10.3
345
2761
49300
ICD-8 Finland
Asthma, bronchiale
8.2
10.2
22
28
A01AB04
ATC
amphotericin B; local oral
3.3
10.2
39
125
R28
ICPC
Limited function/disability (R)
9.1
9.9
20
23
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.2
9.9
100
522
J02AC03
ATC
voriconazole; systemic
26.7
9.9
13
5
J02AC01
ATC
fluconazole; systemic
1.9
9.6
166
1052
JN4AD
NOMESCO Finland
Body CT examination
2.6
9.4
58
242
R24
ICPC
Haemoptysis
22.3
9.4
13
6
J01MA02
ATC
ciprofloxacin; systemic
1.9
9.3
189
1260
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
14.1
9.2
15
11
A07AA02
ATC
nystatin; oral
3.1
9.2
40
138
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
8.6
9.2
19
23
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
10.4
9.1
17
17
XG466
NOMESCO Finland
Sleep oxymetry
4.0
8.8
25
65
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
8.7
88
457
R03BB02
ATC
oxitropium bromide; inhalant
10.3
8.6
16
16
L04AA06
ATC
mycophenolic acid; systemic
8.8
8.4
17
20
B44.0
ICD-10 Finland
Invasive pulmonary aspergillosis
+∞
8.4
8
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
8.3
106
601
A01AB10
ATC
natamycin; local oral
4.2
8.2
22
55
R03AL04
ATC
indacaterol and glycopyrronium bromide; inhalant
22.5
8.0
11
5
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
22.5
8.0
11
5
127
Kela drug reimbursment
Transplant complication
8.7
7.9
16
19
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
15.4
7.8
12
8
R03BB07
ATC
umeclidinium bromide; inhalant
12.1
7.6
13
11
J01DA08
ATC
[U] cefaclor
2.7
7.5
40
155
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
4.5
7.5
18
41
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
4.5
7.5
18
41
B44.8
ICD-10 Finland
Other forms of aspergillosis
81.4
7.4
8
*
R01AD58
ATC
fluticasone, combinations; nasal
2.0
7.4
87
478
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
9.6
7.3
14
15
J01XB01
ATC
colistin; inhalant, parenteral
+∞
7.3
7
*
B02AA02
ATC
tranexamic acid; systemic
2.3
7.2
61
294
J15.1
ICD-10 Finland
Pneumonia due to Pseudomonas
30.6
7.2
9
*
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
30.6
7.2
9
*
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
4.2
7.2
19
47
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
5.8
7.1
19
34
C03CA01
ATC
furosemide; systemic
1.7
7.1
172
1185
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
7.1
103
607
A02BC05
ATC
esomeprazole; systemic
1.7
7.0
182
1279
R06.2
ICD-10 Finland
Wheezing
3.4
6.9
25
77
R29
ICPC
Respiratory symptom/complaint other
2.8
6.9
35
132
N02AX02
ATC
tramadol; systemic, rectal
1.7
6.8
192
1376
H02AB09
ATC
hydrocortisone; systemic
4.4
6.8
17
40
R06AE07
ATC
cetirizine; oral
1.7
6.8
169
1170
4900A
ICD-9 Finland
Bronchitis, not specified as acute or chronic[BRONCHITIS NUD]
22.9
6.7
9
*
F17.20
ICD-10 Finland
Addiction relationship caused by tobacco addiction relationship currently independent
22.9
6.7
9
*
L04AD01
ATC
ciclosporin; systemic
6.6
6.7
16
25
ZXE00
NOMESCO Finland
One hour or less
1.7
6.7
168
1166
J15.8
ICD-10 Finland
Other bacterial pneumonia
12.5
6.6
11
9
R01AD05
ATC
budesonide; nasal
2.7
6.5
36
142
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.8
6.5
118
746
4940A
ICD-9 Finland
Bronchiectasis[BRONCHIECTASIAE]
70.9
6.4
7
*
A01AB09
ATC
miconazole; local oral
2.3
6.4
50
233
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
6.4
63
323
JN4BD
NOMESCO Finland
Extensive body CT
2.2
6.4
58
288
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.7
6.3
168
1180
E84.0
ICD-10 Finland
Cystic fibrosis with pulmonary manifestations
+∞
6.3
6
*
A15.2
ICD-10 Finland
Tuberculosis of lung, confirmed histologically
+∞
6.3
6
*
0310A
ICD-9 Finland
Diseases due to other mycobacteria, Pulmonary
+∞
6.3
6
*
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
5.2
6.3
18
36
Z2221
NOMESCO Finland
Medical doctor
1.8
6.2
115
729
R74
ICPC
Upper respiratory infection acute
1.8
6.2
110
689
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
4.2
6.1
16
39
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.6
6.1
35
141
Z2446
NOMESCO Finland
Social worker
2.6
6.1
34
135
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.1
6.1
25
84
-60
ICPC
Result test/procedure
2.7
6.0
32
124
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
187
108
29.67
243.69
9.6
2.9
—
—
—
0
0
98
31
40.54
155.53
13.2
3.1
—
—
—
0
0
67
21
37.55
105.54
1.9
1.2
2.43
0.14
u/ml
1.31
49
13
84
49
21.02
105.06
1.8
1.6
—
—
—
0
0
89
61
18.10
102.79
1.9
1.6
—
—
—
0
0
91
76
14.89
93.90
2.9
1.3
—
—
—
0
0
68
39
20.49
85.23
1.3
1.2
—
—
—
0
0
73
50
17.35
83.83
1.7
1.7
—
—
—
0
0
75
55
16.28
83.02
1.7
1.6
—
—
—
0
0
59
33
20.53
74.56
2.0
1.5
—
—
—
0
0
109
167
8.38
71.65
2.0
1.2
167.06
279.37
u/ml
0.36
102
153
71
9
93.65
65.29
14.9
5.4
—
—
—
0
0
73
87
9.89
58.38
2.5
1.6
—
—
—
0
0
70
85
9.63
55.09
2.6
1.6
—
—
—
0
0
60
63
10.89
52.48
2.5
1.7
—
—
—
0
0
111
252
5.57
48.32
3.3
2.8
10.65
10.16
g/l
0.47
106
228
35
20
18.95
43.30
1.7
1.2
—
—
—
0
0
169
582
4.12
42.95
3.1
1.8
—
—
—
0
0
43
40
11.82
40.59
2.6
1.6
—
—
—
0
0
34
23
15.95
38.63
1.9
1.6
—
—
—
0
0
43
58
8.12
30.67
2.9
1.6
—
—
—
0
0
43
58
8.12
30.67
2.9
1.6
—
—
—
0
0
41
53
8.44
30.28
2.4
1.5
—
—
—
0
0
316
1936
3.33
28.25
19.2
8.6
4.89
4.13
e9/l
5.10
304
1691
42
61
7.52
28.07
5.3
2.9
5.42
4.29
e9/l
1.33
42
61
30
29
11.04
27.41
2.0
1.7
—
—
—
0
0
114
402
3.49
26.45
2.7
1.7
—
—
—
0
0
42
66
6.94
26.12
5.4
3.4
62.98
58.52
%
1.16
42
66
110
402
3.33
23.89
2.8
1.8
—
—
—
0
0
135
558
3.06
23.79
8.2
3.1
0.81
0.82
mmol/l
0.54
130
519
32
17
20.22
21.61
1.9
1.6
—
—
—
0
0
46
95
5.30
21.60
1.8
1.4
—
—
—
0
0
82
264
3.60
21.60
1.7
1.6
—
—
—
0
0
32
18
19.08
21.20
1.9
1.6
—
—
—
0
0
292
1884
2.68
20.55
13.5
6.0
8.94
11.28
umol/l
8.98
283
1775
37
66
6.04
20.28
14.9
6.3
139.00
157.89
iu/ml
—
7
9
26
32
8.58
19.83
2.1
1.8
—
—
—
0
0
26
32
8.58
19.83
2.1
1.8
—
—
—
0
0
26
32
8.58
19.83
2.1
1.8
—
—
—
0
0
43
96
4.86
18.42
2.1
1.5
0.17
0.07
iu/ml
—
5
18
25
11
24.02
17.95
1.6
1.4
—
—
—
0
0
68
221
3.46
17.49
5.6
3.6
1.79
1.91
mmol/l
0.09
53
169
27
41
6.96
17.22
2.7
1.7
—
—
—
0
0
27
42
6.79
16.84
2.7
1.6
—
—
—
0
0
52
146
3.91
16.57
3.5
1.7
—
—
—
0
0
33
64
5.50
16.54
1.8
1.2
—
—
—
0
0
33
64
5.50
16.54
1.8
1.2
—
—
—
0
0
275
1845
2.34
15.93
11.4
6.3
1.22
1.22
mmol/l
0.03
225
1544
254
1679
2.24
14.82
10.4
5.6
1.22
1.22
mmol/l
0.23
242
1492
47
135
3.78
14.47
2.8
1.6
—
—
—
0
0
23
17
14.21
13.88
3.7
2.6
—
—
—
0
0
21
13
16.90
13.58
1.3
1.2
—
—
—
0
0
22
16
14.41
13.38
2.2
1.9
—
—
—
0
0
22
16
14.41
13.38
2.2
1.9
—
—
—
0
0
337
2569
2.40
13.06
11.5
4.0
19.19
13.24
mm/h
6.97
328
2324
16
5
33.13
12.65
2.6
1.4
—
—
—
0
0
18
12
15.58
11.40
2.3
2.2
—
—
—
0
0
18
12
15.58
11.40
2.3
2.2
—
—
—
0
0
18
13
14.38
11.06
2.4
2.1
—
—
—
0
0
27
64
4.43
10.71
1.4
1.3
—
—
—
0
0
21
42
5.20
10.15
3.6
1.5
—
—
—
0
0
21
42
5.20
10.15
3.6
1.5
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
35
106
3.50
9.94
4.1
2.3
0.42
0.36
u/ml
0.46
22
59
27
69
4.11
9.74
2.6
2.2
15.45
15.77
%
0.13
15
34
26
66
4.13
9.46
1.8
2.1
121.41
129.46
g/l
0.68
17
52
224
1582
1.86
9.13
6.1
4.4
32.88
35.28
g/l
6.16
206
1470
69
318
2.39
9.10
1.8
2.7
64.52
65.90
g/l
0.67
59
285
21
31
7.06
8.95
1.1
1.1
—
—
—
0
0
25
66
3.96
8.64
1.2
1.1
—
—
—
0
0
144
900
1.90
8.49
2.5
2.1
3.27
3.21
mg/l
0.10
129
752
51
211
2.61
8.43
2.4
1.7
—
—
—
0
0
198
1371
1.82
8.39
3.1
2.7
121.10
130.99
ug/l
0.37
185
1224
242
1780
1.81
8.38
18.1
15.5
1.23
1.30
inr
0.64
92
517
333
2731
1.94
7.83
18.3
7.3
81.32
80.34
u/l
0.15
328
2537
96
538
2.01
7.71
1.3
1.3
84.26
41.37
iu/ml
0.55
34
166
232
1721
1.75
7.48
3.3
2.6
—
—
—
0
0
10
5
20.42
7.16
3.0
1.4
—
—
—
0
0
173
1193
1.75
7.13
3.5
3.0
1301.03
1456.13
ng/l
0.30
156
1011
10
6
17.02
6.77
3.3
1.5
—
—
—
0
0
264
2072
1.70
6.58
9.0
4.7
6.54
6.77
mmol/l
1.13
256
1938
156
1065
1.73
6.55
4.6
3.0
32.55
32.12
u/l
0.04
151
1014
94
559
1.87
6.24
3.0
2.4
11.78
12.54
umol/l
0.48
88
513
78
439
1.95
6.11
11.2
5.1
1.03
1.06
mmol/l
0.40
73
398
17
45
3.89
5.87
2.1
1.8
89.40
89.78
%
0.10
17
45
17
46
3.81
5.70
1.7
1.3
—
—
—
0
0
31
123
2.64
5.59
1.9
2.2
0.87
0.43
g/l
0.36
26
105
112
732
1.71
5.35
2.6
1.6
1.33
1.32
mg/l
0.01
89
578
69
391
1.91
5.28
9.4
7.6
2.87
1.17
mmol/l
2.80
60
309
30
127
2.46
4.76
1.8
3.1
—
2.70
—
0
12
18
58
3.19
4.69
1.1
1.3
—
—
—
0
0
30
128
2.44
4.69
1.9
3.2
212.95
113.83
mg/l
0.24
21
96
30
128
2.44
4.69
1.8
3.2
32.73
27.26
mg/l
0.53
22
96
79
485
1.77
4.66
3.3
2.4
19.01
21.89
%
1.47
70
410
56
310
1.93
4.58
3.8
3.0
179.16
183.70
ng/l
0.04
51
279
188
1444
1.53
4.49
5.2
3.9
69.80
64.77
ng/l
0.04
148
1095
80
503
1.72
4.34
3.3
2.4
2.29
2.29
g/l
0.04
74
464
33
153
2.25
4.30
2.2
1.9
—
—
—
0
0
10
17
5.99
4.15
2.3
2.5
614.60
926.41
u/ml
—
10
17
139
1017
1.54
4.06
5.8
3.1
0.32
0.50
e6/l
0.67
120
778
149
1108
1.53
4.04
5.6
3.2
15.78
102.05
e6/l
0.88
129
868
7
7
10.14
4.02
1.1
1.1
97.86
101.57
%
—
7
7
79
506
1.69
3.99
1.2
1.3
14.61
13.46
u/ml
0.03
19
178
170
1303
1.50
3.98
5.6
3.2
—
—
—
0
0
163
1245
1.50
3.86
4.8
3.3
2.34
2.36
mmol/l
1.09
147
1079
102
704
1.59
3.83
1.3
1.3
1.26
1.67
u/ml
0.36
21
167
187
1471
1.48
3.81
2.7
2.2
83.80
77.93
nmol/l
2.19
165
1266
7
8
8.87
3.78
1.9
1.0
0.74
3.90
mmol/l
—
7
8
63
386
1.74
3.73
5.9
3.5
—
—
—
0
0
8
12
6.77
3.69
4.4
1.4
24.38
30.58
umol/l
—
8
12
15
51
3.01
3.61
1.1
1.2
124.83
104.55
u/ml
—
6
11
126
928
1.50
3.50
1.5
1.6
19.94
21.35
nmol/l
0.51
108
762
15
53
2.90
3.39
1.3
1.2
—
—
—
0
0
150
1154
1.46
3.33
3.1
2.4
59.37
61.18
u/l
0.09
141
1061
24
112
2.21
3.12
1.4
1.4
276.42
284.03
ug/g
0.06
12
58
306
3371
0.69
3.05
5.5
5.3
2.54
2.67
mmol/l
2.08
272
3025
57
361
1.67
3.01
9.2
3.3
3.16
1.92
mmol/l
1.47
52
282
10
26
3.91
2.99
1.4
1.2
—
—
—
0
0
13
46
2.88
2.94
1.2
1.0
—
—
—
0
0
6
9
6.74
2.87
1.0
1.1
—
—
—
0
0
97
708
1.48
2.77
4.6
3.8
420.61
242.59
ng/l
0.49
78
588
32
176
1.88
2.72
1.9
1.9
1.79
1.56
g/l
0.73
26
154
17
73
2.38
2.68
2.4
1.5
—
—
—
0
0
11
38
2.94
2.43
1.1
1.1
—
—
—
0
0
7
18
3.93
2.26
1.3
1.4
—
—
—
0
0
7
18
3.93
2.26
1.3
1.4
—
—
—
0
0
12
48
2.54
2.20
1.4
1.5
—
—
—
0
0
7
19
3.73
2.16
1.0
1.9
—
—
—
0
0
9
30
3.04
2.16
1.0
1.2
—
—
—
0
0
303
3288
0.74
2.13
5.0
4.7
4.52
4.58
mmol/l
0.52
265
2959
100
769
1.39
2.13
1.8
1.8
1358.59
1180.98
nmol/l
0.97
74
552
6
15
4.04
2.04
3.3
1.6
74.67
70.92
ug/l
—
6
15
12
50
2.44
2.04
1.4
1.5
—
—
—
0
0
12
50
2.44
2.04
1.4
1.5
—
—
—
0
0
12
50
2.44
2.04
1.4
1.5
—
—
—
0
0
12
50
2.44
2.04
1.4
1.5
—
—
—
0
0
7
21
3.37
1.97
1.3
1.4
—
—
—
0
0
12
51
2.39
1.96
1.4
1.5
—
—
—
0
0
34
214
1.64
1.89
1.6
1.3
—
—
—
0
0
306
3298
0.76
1.87
5.3
4.9
5.85
6.03
mmol/l
1.80
276
2931
302
3260
0.76
1.86
5.0
4.6
1.61
1.48
mmol/l
3.73
266
2917
56
397
1.47
1.86
3.1
2.8
5.90
9.14
umol/l
1.22
51
350
47
323
1.51
1.81
2.3
2.4
32.08
31.97
u/l
0.01
40
269
8
29
2.79
1.80
1.1
1.2
—
—
—
0
0
8
29
2.79
1.80
1.1
1.2
—
—
—
0
0
6
18
3.36
1.75
1.5
1.6
—
—
—
0
0
6
18
3.36
1.75
1.5
1.6
—
—
—
0
0
92
721
1.35
1.73
2.7
3.0
2.49
2.46
mmol/l
1.62
81
634
21
118
1.82
1.73
1.5
1.2
—
—
—
0
0
181
1557
1.28
1.73
2.0
2.0
95.21
95.31
pmol/l
0.01
104
773
8
30
2.70
1.73
1.5
1.2
—
—
—
0
0
106
852
1.32
1.68
3.4
2.3
—
—
—
0
0
18
97
1.89
1.68
2.5
2.6
173.60
103.19
ug/min
0.44
12
62
109
880
1.32
1.68
5.1
2.8
3645.83
8288.49
umol/l
0.65
103
742
296
3189
0.77
1.67
6.3
6.2
40.41
40.44
mmol/mol
0.02
274
2910
58
425
1.42
1.63
1.3
1.4
—
—
—
0
0
8
32
2.53
1.60
3.0
2.6
—
—
—
0
0
10
44
2.30
1.56
1.2
1.1
—
—
—
0
0
10
44
2.30
1.56
1.4
1.1
1.40
1.50
u/ml
—
5
12
8
33
2.45
1.54
3.0
1.9
—
—
—
0
0
78
608
1.34
1.53
4.2
2.8
0.83
1.28
e6/l
0.97
51
362
6
21
2.88
1.51
1.3
1.4
—
—
—
0
0
7
28
2.52
1.45
2.0
1.5
—
—
—
0
0
355
3354
1.32
1.44
40.7
15.0
23.63
23.87
mg/l
0.06
333
2680
9
42
2.17
1.34
2.8
2.2
—
—
—
0
0
101
836
1.27
1.28
1.7
1.7
453.22
9023000.30
pmol/l
0.50
81
665
131
1119
1.24
1.27
3.1
2.0
121.29
197.62
u/l
2.51
125
1035
279
2578
1.23
1.27
4.5
3.8
15.14
14.92
pmol/l
0.70
253
2273
5
19
2.65
1.22
2.2
1.2
—
—
—
0
0
12
64
1.90
1.19
2.2
2.6
28.80
26.93
mg/l
—
5
23
17
102
1.69
1.18
2.2
1.5
—
—
—
0
0
226
2058
1.20
1.14
7.0
3.1
46.61
51.66
u/l
0.45
214
1885
44
329
1.38
1.14
2.1
2.5
8.35
7.31
ug/l
0.16
36
284
5
21
2.40
1.09
1.0
1.0
—
—
—
0
0
297
3146
0.82
1.09
4.4
4.2
1.15
1.27
mmol/l
3.57
257
2790
14
82
1.73
1.06
1.4
1.3
—
—
—
0
0
16
98
1.66
1.04
2.9
1.6
—
—
—
0
0
31
223
1.42
1.02
5.3
8.4
27.02
24.45
mmol/l
2.13
31
210
9
161
0.55
1.00
1.4
3.1
29.33
1930.88
u/ml
—
9
138
5
23
2.19
0.98
1.6
1.4
54.40
87.13
umol/l
—
5
23
70
576
1.26
0.95
4.7
3.0
3.60
2.93
e6/l
0.20
44
332
63
765
0.79
0.93
4.4
4.5
1.01
1.02
kg/l
0.57
17
110
70
837
0.80
0.90
4.0
4.4
19.98
21.61
%
0.41
30
429
36
273
1.35
0.89
3.0
2.7
75.74
60.42
ml/min/173m2
1.55
19
115
107
934
1.19
0.83
6.4
4.4
0.00
0.00
estimate
-0.00
54
318
12
73
1.66
0.82
1.1
1.2
—
—
—
0
0
13
82
1.60
0.79
1.1
1.4
—
—
—
0
0
5
24
2.10
0.74
1.0
1.1
—
—
—
0
0
5
25
2.01
0.73
1.0
1.2
—
—
—
0
0
5
25
2.01
0.73
1.0
1.2
—
—
—
0
0
5
25
2.01
0.73
1.0
1.2
—
—
—
0
0
5
25
2.01
0.73
1.0
1.2
—
—
—
0
0
5
25
2.01
0.73
1.0
1.2
—
—
—
0
0
10
60
1.68
0.72
1.2
1.4
233.80
298.73
miu/ml
—
5
23
21
152
1.40
0.70
2.0
1.3
—
—
—
0
0
38
472
0.79
0.70
8.2
7.4
—
—
—
0
0
16
110
1.47
0.69
1.8
1.6
—
—
—
0
0
5
29
1.73
0.64
1.2
1.1
—
—
—
0
0
358
3679
0.85
0.63
53.5
22.4
39.25
39.61
%
0.59
345
3423
11
72
1.54
0.59
1.1
1.2
—
16.28
—
0
5
52
606
0.84
0.54
3.3
3.1
0.96
0.83
ug/l
0.15
37
408
34
413
0.81
0.54
1.4
1.4
—
—
—
0
0
329
3185
1.14
0.52
30.6
14.6
78.29
75.06
ml/min/173m2
2.08
301
2613
6
40
1.51
0.52
1.3
1.1
—
—
—
0
0
95
1051
0.88
0.51
5.8
5.1
2.90
3.07
ug/l
0.07
80
926
7
47
1.50
0.47
1.3
1.6
—
—
—
0
0
15
113
1.34
0.43
1.7
1.2
—
—
—
0
0
8
56
1.44
0.42
1.4
1.8
—
—
—
0
0
12
87
1.39
0.42
1.3
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
159.28
—
0
16
322
3131
1.11
0.41
5.4
4.7
1.89
2.39
mu/l
0.68
295
2785
180
1704
1.10
0.40
5.7
4.1
0.00
0.00
estimate
0.50
57
353
24
196
1.24
0.40
3.4
3.2
27.29
24.78
mmol/l
2.11
24
191
8
61
1.32
0.39
1.6
1.6
27.63
19.51
iu/l
—
8
52
108
1166
0.90
0.39
5.4
3.7
12.15
9.82
mg/mmol
0.20
82
721
15
115
1.32
0.39
1.7
1.2
—
—
—
0
0
97
894
1.11
0.37
1.7
1.6
1.25
1.32
mmol/l
0.44
81
725
9
70
1.29
0.37
1.3
1.9
—
—
—
0
0
5
79
0.63
0.36
1.6
1.5
—
—
—
0
0
16
199
0.80
0.34
1.2
1.2
75.42
141.46
iu/ml
—
8
72
180
1716
1.08
0.33
7.5
5.6
0.00
0.00
estimate
-0.00
58
321
181
1730
1.08
0.31
5.8
4.1
0.00
0.00
estimate
-0.00
56
313
53
477
1.13
0.31
4.4
4.8
36.82
32.02
%
2.23
40
300
128
1346
0.93
0.26
6.5
4.4
—
—
—
0
0
10
77
1.31
0.26
1.5
1.2
—
—
—
0
0
169
1625
1.07
0.24
3.2
2.6
—
—
—
0
0
10
78
1.29
0.24
1.1
1.1
—
11.92
—
0
9
19
162
1.18
0.23
1.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
354.88
—
0
8
6
49
1.23
0.20
1.5
1.3
0.50
0.60
nmol/l
—
6
44
21
186
1.14
0.17
1.3
1.4
—
33.39
—
0
16
9
83
1.09
0.14
1.0
1.3
—
—
—
0
0
108
1119
0.95
0.14
4.2
3.1
6.00
7.09
mmol/l
2.41
100
922
5
45
1.11
0.10
1.0
1.0
—
—
—
0
0
17
185
0.92
0.08
1.5
1.8
—
—
—
0
0
22
236
0.93
0.08
17.8
3.1
127.41
125.57
g/l
0.15
22
231
5
65
0.77
0.08
1.4
1.3
—
—
—
0
0
7
81
0.86
0.07
1.7
1.5
113.57
232.94
pmol/l
—
7
81
18
171
1.05
0.03
5.8
2.8
38.78
56.93
u/ml
0.35
18
166
16
168
0.95
0.02
1.9
2.0
—
—
—
0
0
15
153
0.98
0.00
2.0
1.8
—
—
—
0
0
6
64
0.94
0.00
1.2
1.2
1.27
0.82
nmol/l
—
6
52
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
66
0.91
-0.00
1.2
1.2
21.77
20.84
u/l
—
6
55
0
7
0.00
-0.00
0.0
1.7
—
8.53
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
13.40
—
0
5
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
44.80
—
0
5
0
5
0.00
-0.00
0.0
4.0
—
59.62
—
0
5
6
59
1.02
-0.00
1.5
1.6
163.67
242.21
pmol/l
—
6
53
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
1.19
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint MYCOBLUNGATYPICA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MYCOBLUNGATYPICA | 1.744 [1.51, 2.02] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.209 |
During the follow-up period (1.1.1998 — 31.12.2019), 571 out of 1246 females with MYCOBLUNGATYPICA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MYCOBLUNGATYPICA | 3.148 [2.47, 4.01] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 490 out of 842 males with MYCOBLUNGATYPICA died.
Mortality risk
Mortality risk for people of age
years, who have MYCOBLUNGATYPICA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.123% | 0.602% |
| 5 | 0.936% | 3.554% |
| 10 | 2.477% | 8.216% |
| 15 | 5.023% | 15.414% |
| 20 | 8.501% | 25.509% |
Relationships between endpoints
↥Index endpoint: MYCOBLUNGATYPICA – Atypical mycobacterium lung infection
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data