No definition available.
Malignant neoplasm of anus and anal canal, excluding all cancers (controls excluding all cancers)
C3_ANUS_ANALCANAL_EXALLC
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
420 |
4. Check minimum number of eventsNone |
420 |
5. Include endpointsNone |
420 |
6. Filter based on genotype QC (FinnGen only) |
420 |
Control definitions (FinnGen only)
- Control exclude
- C3_CANCER, C3_CANCER_WIDE_EXALLC
Extra metadata
- First used in FinnGen datafreeze
- DF12
Similar endpoints
↥List of similar endpoints to
Malignant neoplasm of anus and anal canal, excluding all cancers (controls excluding all cancers)
based on the number of shared cases.
Similar with more cases:
- Malignant neoplasm of digestive organs, excluding all cancers (controls excluding all cancers)
- Malignant neoplasm, excluding all cancers (controls excluding all cancers)
- Malignant neoplasm, wide definition for exclusion
- Malignant neoplasm, wide definition for exclusion, excluding all cancers (controls excluding all cancers)
- Neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 420 | 231 | 189 |
| Unadjusted period prevalence (%) | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | 65.00 | 62.32 | 68.28 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 145
- Matched controls
- 1451
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C21.1
ICD-10 Finland
Malignant neoplasm: Anal canal
+∞
120.1
98
*
C21.0
ICD-10 Finland
Malignant neoplasm: Anus, unspecified
+∞
90.3
77
*
130
Kela drug reimbursment
Malignant tumour
+∞
86.3
74
*
WF002
NOMESCO Finland
Radical radiotherapy
1057.4
69.0
62
*
8070/3-C21.0
ICD-O-3
Squamous cell carcinoma, NOS, of anus, NOS
+∞
63.2
56
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
58.3
52
*
A03FA01
ATC
metoclopramide; systemic, rectal
24.0
58.1
95
106
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
28.0
53.3
77
56
8070/3-C21.1
ICD-O-3
Squamous cell carcinoma, NOS, of anal canal
+∞
48.7
44
*
L01BC06
ATC
capecitabine; oral
+∞
45.2
41
*
UJH02
NOMESCO Finland
Anoscopy
31.5
42.4
57
29
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
41.7
38
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
39.4
36
*
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
+∞
35.9
33
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
34.8
32
*
C21.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of rectum, anus and anal canal
+∞
33.7
31
*
N02AA05
ATC
oxycodone; systemic
12.5
33.2
67
93
JN4BD
NOMESCO Finland
Extensive body CT
20.1
32.8
51
38
JG1CG
NOMESCO Finland
Extensive MRI of rectum
203.4
32.1
32
*
YJ2VG
NOMESCO Finland
MRI examination of pelvis with high intensity magnet for dose design of radiotherapy
+∞
31.4
29
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
30.3
28
*
H02AB02
ATC
dexamethasone; systemic
97.6
29.1
31
*
A04AA01
ATC
ondansetron; systemic, rectal
53.3
25.7
30
7
D37.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Rectum
+∞
24.7
23
*
JG1BG
NOMESCO Finland
MRI of rectum
+∞
23.6
22
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
23.6
22
*
C20.99
ICD-10 Finland
Malignant tumor of the rectum other or unspecified histology
+∞
22.5
21
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
22.5
21
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
21.4
20
*
UJF32
NOMESCO Finland
Coloscopy
5.8
20.8
78
242
WX302
NOMESCO Finland
Thoracal epidural anesthesy
54.2
19.9
23
5
UJG02
NOMESCO Finland
Proctoscopy
28.4
19.5
26
11
XX3DW
NOMESCO Finland
Time consuming IT work
15.4
19.3
32
26
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
19.2
18
*
JHA10
NOMESCO Finland
Biopsy of anal canal
216.9
19.0
19
*
ZX095
NOMESCO Finland
Combined chemoradiotherapy
+∞
17.0
16
*
JHA00
NOMESCO Finland
Anal or perianal incision
38.3
16.2
20
6
WB111
NOMESCO Finland
Multiple neoadjuvant cytostatic therapy
+∞
15.9
15
*
JGB30
NOMESCO Finland
Abdominoperineal excision of rectum
+∞
15.9
15
*
Z51.5
ICD-10 Finland
Palliative care
16.8
14.6
23
16
JN4AD
NOMESCO Finland
Body CT examination
12.3
13.9
25
24
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
13.8
13
*
YL1AD
NOMESCO Finland
CT examination of pelvis for dose design of radiotherapy
+∞
13.8
13
*
TPH07
NOMESCO Finland
Cathetrisation of artery
7.5
13.5
33
55
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
12.7
12
*
ZZR00
NOMESCO Finland
Flap of skin
+∞
12.7
12
*
WF001
NOMESCO Finland
Preoperative radiotherapy
+∞
12.7
12
*
C20.92
ICD-10 Finland
Malignant tumor of the rectum carcinoma of the adenoma
+∞
12.7
12
*
D75
ICPC
Malignant neoplasm colon/rectum
141.8
12.6
13
*
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
14.2
12.6
21
17
WW500
NOMESCO Finland
Blood transfusion
20.3
12.4
18
10
JHA20
NOMESCO Finland
Excision of lesion of anal canal or perianal tissue
23.8
12.3
17
8
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.0
12.3
61
222
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
11.6
11
*
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
+∞
11.6
11
*
JH1CG
NOMESCO Finland
Extensive MRI of perianal area
+∞
11.6
11
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
11.6
11
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
64.9
10.8
12
*
ULA02
NOMESCO Finland
Kolposcopy
6.8
10.6
27
47
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
10.5
10
*
C20
ICD-10 Finland
Malignant neoplasm of rectum
+∞
10.5
10
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
10.5
10
*
WX402
NOMESCO Finland
General anaesthesia
5.0
10.3
35
87
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
19.2
9.6
14
8
Z93.3
ICD-10 Finland
Colostomy status
106.7
9.5
10
*
PJD45
NOMESCO Finland
Excision of inguinal lymph nodes
+∞
9.5
9
*
C21.2
ICD-10 Finland
Malignant neoplasm: Cloacogenic zone
+∞
9.5
9
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
9.3
9.4
19
23
WX408
NOMESCO Finland
General anesthesy, balanced
3.5
9.4
53
207
R50.9
ICD-10 Finland
Fever, unspecified
4.5
9.1
34
93
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
15.3
8.9
14
10
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.7
8.6
30
76
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
13.9
8.6
14
11
P01AB01
ATC
metronidazole; oral, rectal
2.9
8.6
78
418
WX600
NOMESCO Finland
Single shot through catheter
95.4
8.5
9
*
WZC30
NOMESCO Finland
Teaching
4.7
8.4
29
73
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
+∞
8.4
8
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
8.4
8
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
8.4
8
*
JGB36
NOMESCO Finland
Wide excision of rectum
+∞
8.4
8
*
A04AD12
ATC
aprepitant; systemic
+∞
8.4
8
*
8140/3-C21.1
ICD-O-3
Adenocarcinoma, NOS, of anal canal
+∞
8.4
8
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
8.4
8
*
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
+∞
8.4
8
*
YL1CD
NOMESCO Finland
Very extensive CT examination of pelvis for dose design of radiotherapy
+∞
8.4
8
*
JG1DG
NOMESCO Finland
Very extensive MRI of rectum
+∞
8.4
8
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
8.4
8
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.8
8.2
72
374
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
6.0
8.1
22
42
R4110
NOMESCO Finland
Physiotherapy
3.1
7.6
50
213
ZX120
NOMESCO Finland
Intravenous
6.5
7.5
19
33
B01AB10
ATC
tinzaparin; parenteral
6.5
7.5
19
33
ZXE00
NOMESCO Finland
One hour or less
2.7
7.5
68
355
TPX10
NOMESCO Finland
Implantation of vascular injection port
10.2
7.5
14
15
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
7.3
7
*
JF1CM
NOMESCO Finland
Small bowel extensive MRI with with high intensity magnet
+∞
7.3
7
*
115
Kela drug reimbursment
Breast cancer
+∞
7.3
7
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
7.3
7
*
JN2CM
NOMESCO Finland
Lower part of abdomen extensive MRI examination with Tesla magnet
+∞
7.3
7
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.2
7.3
28
78
K60.2
ICD-10 Finland
Anal fissure, unspecified
21.3
7.2
10
5
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
31.7
7.2
9
*
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
10.9
7.2
13
13
B01AB05
ATC
enoxaparin; parenteral
2.7
7.0
59
292
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
4.4
6.9
25
66
JN2DG
NOMESCO Finland
Very extensive MRI examination of lower part of abdoment with high intensity magnet
42.1
6.8
8
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.9
6.8
28
84
JFF23
NOMESCO Finland
Transversostomy
23.8
6.8
9
*
N02AX02
ATC
tramadol; systemic, rectal
2.5
6.7
75
432
Z2221
NOMESCO Finland
Medical doctor
2.8
6.6
50
230
SPAT1125
SPAT
Stoma care and guidance
15.2
6.5
10
7
ZZA00
NOMESCO Finland
Split skin graft
15.2
6.5
10
7
QBB05
NOMESCO Finland
Revision of wound of skin of trunk
72.9
6.5
7
*
TJF80
NOMESCO Finland
Ostomy education
72.9
6.5
7
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
4.0
6.4
25
71
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.2
6.4
19
41
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.3
6.4
16
28
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
28.0
6.3
8
*
K62.9
ICD-10 Finland
Disease of anus and rectum, unspecified
28.0
6.3
8
*
JGB37
NOMESCO Finland
Laparoscopic wide excision of rectum
+∞
6.3
6
*
HAC20
NOMESCO Finland
Total mastectomy
+∞
6.3
6
*
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
+∞
6.3
6
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
6.3
6
*
Z51.0
ICD-10 Finland
Radiotherapy session
+∞
6.3
6
*
JG1CM
NOMESCO Finland
Extensive MRI of rectum (more than 1.5 T)
+∞
6.3
6
*
WB121
NOMESCO Finland
Demanding neoadjuvant cytostatic therapy
+∞
6.3
6
*
ZZR10
NOMESCO Finland
Flap of skin and muscle
+∞
6.3
6
*
D37.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Digestive organ, unspecified
+∞
6.3
6
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.0
6.2
38
153
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
6.6
6.2
15
25
D18
ICPC
Change in faeces/bowel movements
13.3
6.2
10
8
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
7.8
6.1
13
18
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: C3_ANUS_ANALCANAL_EXALLC – Malignant neoplasm of anus and anal canal, excluding all cancers (controls excluding all cancers)
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).