Malignant neoplasm of anus and anal canal, excluding all cancers (controls excluding all cancers)

C3_ANUS_ANALCANAL_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C21
  • Hospital discharge: ICD-9 154[2-3]
  • Hospital discharge: ICD-8 1542
  • Cause of death: ICD-10 C21
  • Cause of death: ICD-9 154[2-3]
  • Cause of death: ICD-8 1542
  • Cancer registry: Topography ICD-O-3 C21
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

420

4. Check minimum number of events

None

420

5. Include endpoints

None

420

6. Filter based on genotype QC (FinnGen only)

420

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of anus and anal canal, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 420 231 189
Unadjusted period prevalence (%) 0.08 0.08 0.08
Median age at first event (years) 65.00 62.32 68.28

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
145
Matched controls
1451
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C21.1
ICD-10 Finland
Malignant neoplasm: Anal canal
+∞
120.1
98
*
C21.0
ICD-10 Finland
Malignant neoplasm: Anus, unspecified
+∞
90.3
77
*
130
Kela drug reimbursment
Malignant tumour
+∞
86.3
74
*
WF002
NOMESCO Finland
Radical radiotherapy
1057.4
69.0
62
*
8070/3-C21.0
ICD-O-3
Squamous cell carcinoma, NOS, of anus, NOS
+∞
63.2
56
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
58.3
52
*
A03FA01
ATC
metoclopramide; systemic, rectal
24.0
58.1
95
106
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
28.0
53.3
77
56
8070/3-C21.1
ICD-O-3
Squamous cell carcinoma, NOS, of anal canal
+∞
48.7
44
*
L01BC06
ATC
capecitabine; oral
+∞
45.2
41
*
UJH02
NOMESCO Finland
Anoscopy
31.5
42.4
57
29
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
41.7
38
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
39.4
36
*
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
+∞
35.9
33
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
34.8
32
*
C21.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of rectum, anus and anal canal
+∞
33.7
31
*
N02AA05
ATC
oxycodone; systemic
12.5
33.2
67
93
JN4BD
NOMESCO Finland
Extensive body CT
20.1
32.8
51
38
JG1CG
NOMESCO Finland
Extensive MRI of rectum
203.4
32.1
32
*
YJ2VG
NOMESCO Finland
MRI examination of pelvis with high intensity magnet for dose design of radiotherapy
+∞
31.4
29
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
30.3
28
*
H02AB02
ATC
dexamethasone; systemic
97.6
29.1
31
*
A04AA01
ATC
ondansetron; systemic, rectal
53.3
25.7
30
7
D37.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Rectum
+∞
24.7
23
*
JG1BG
NOMESCO Finland
MRI of rectum
+∞
23.6
22
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
23.6
22
*
C20.99
ICD-10 Finland
Malignant tumor of the rectum other or unspecified histology
+∞
22.5
21
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
22.5
21
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
21.4
20
*
UJF32
NOMESCO Finland
Coloscopy
5.8
20.8
78
242
WX302
NOMESCO Finland
Thoracal epidural anesthesy
54.2
19.9
23
5
UJG02
NOMESCO Finland
Proctoscopy
28.4
19.5
26
11
XX3DW
NOMESCO Finland
Time consuming IT work
15.4
19.3
32
26
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
19.2
18
*
JHA10
NOMESCO Finland
Biopsy of anal canal
216.9
19.0
19
*
ZX095
NOMESCO Finland
Combined chemoradiotherapy
+∞
17.0
16
*
JHA00
NOMESCO Finland
Anal or perianal incision
38.3
16.2
20
6
WB111
NOMESCO Finland
Multiple neoadjuvant cytostatic therapy
+∞
15.9
15
*
JGB30
NOMESCO Finland
Abdominoperineal excision of rectum
+∞
15.9
15
*
Z51.5
ICD-10 Finland
Palliative care
16.8
14.6
23
16
JN4AD
NOMESCO Finland
Body CT examination
12.3
13.9
25
24
YL1AD
NOMESCO Finland
CT examination of pelvis for dose design of radiotherapy
+∞
13.8
13
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
13.8
13
*
TPH07
NOMESCO Finland
Cathetrisation of artery
7.5
13.5
33
55
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
12.7
12
*
ZZR00
NOMESCO Finland
Flap of skin
+∞
12.7
12
*
WF001
NOMESCO Finland
Preoperative radiotherapy
+∞
12.7
12
*
C20.92
ICD-10 Finland
Malignant tumor of the rectum carcinoma of the adenoma
+∞
12.7
12
*
D75
ICPC
Malignant neoplasm colon/rectum
141.8
12.6
13
*
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
14.2
12.6
21
17
WW500
NOMESCO Finland
Blood transfusion
20.3
12.4
18
10
JHA20
NOMESCO Finland
Excision of lesion of anal canal or perianal tissue
23.8
12.3
17
8
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.0
12.3
61
222
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
+∞
11.6
11
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
11.6
11
*
JH1CG
NOMESCO Finland
Extensive MRI of perianal area
+∞
11.6
11
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
11.6
11
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
64.9
10.8
12
*
ULA02
NOMESCO Finland
Kolposcopy
6.8
10.6
27
47
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
10.5
10
*
C20
ICD-10 Finland
Malignant neoplasm of rectum
+∞
10.5
10
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
10.5
10
*
WX402
NOMESCO Finland
General anaesthesia
5.0
10.3
35
87
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
19.2
9.6
14
8
Z93.3
ICD-10 Finland
Colostomy status
106.7
9.5
10
*
PJD45
NOMESCO Finland
Excision of inguinal lymph nodes
+∞
9.5
9
*
C21.2
ICD-10 Finland
Malignant neoplasm: Cloacogenic zone
+∞
9.5
9
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
9.3
9.4
19
23
WX408
NOMESCO Finland
General anesthesy, balanced
3.5
9.4
53
207
R50.9
ICD-10 Finland
Fever, unspecified
4.5
9.1
34
93
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
15.3
8.9
14
10
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.7
8.6
30
76
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
13.9
8.6
14
11
P01AB01
ATC
metronidazole; oral, rectal
2.9
8.6
78
418
WX600
NOMESCO Finland
Single shot through catheter
95.4
8.5
9
*
WZC30
NOMESCO Finland
Teaching
4.7
8.4
29
73
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
+∞
8.4
8
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
8.4
8
*
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
+∞
8.4
8
*
A04AD12
ATC
aprepitant; systemic
+∞
8.4
8
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
8.4
8
*
JGB36
NOMESCO Finland
Wide excision of rectum
+∞
8.4
8
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
8.4
8
*
YL1CD
NOMESCO Finland
Very extensive CT examination of pelvis for dose design of radiotherapy
+∞
8.4
8
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
8.4
8
*
JG1DG
NOMESCO Finland
Very extensive MRI of rectum
+∞
8.4
8
*
8140/3-C21.1
ICD-O-3
Adenocarcinoma, NOS, of anal canal
+∞
8.4
8
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
6.0
8.1
22
42
R4110
NOMESCO Finland
Physiotherapy
3.1
7.6
50
213
B01AB10
ATC
tinzaparin; parenteral
6.5
7.5
19
33
ZX120
NOMESCO Finland
Intravenous
6.5
7.5
19
33
TPX10
NOMESCO Finland
Implantation of vascular injection port
10.2
7.5
14
15
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
7.3
7
*
JN2CM
NOMESCO Finland
Lower part of abdomen extensive MRI examination with Tesla magnet
+∞
7.3
7
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
7.3
7
*
JF1CM
NOMESCO Finland
Small bowel extensive MRI with with high intensity magnet
+∞
7.3
7
*
115
Kela drug reimbursment
Breast cancer
+∞
7.3
7
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.2
7.3
28
78
K60.2
ICD-10 Finland
Anal fissure, unspecified
21.3
7.2
10
5
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
31.7
7.2
9
*
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
10.9
7.2
13
13
B01AB05
ATC
enoxaparin; parenteral
2.7
7.0
59
292
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
4.4
6.9
25
66
JN2DG
NOMESCO Finland
Very extensive MRI examination of lower part of abdoment with high intensity magnet
42.1
6.8
8
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.9
6.8
28
84
JFF23
NOMESCO Finland
Transversostomy
23.8
6.8
9
*
N02AX02
ATC
tramadol; systemic, rectal
2.5
6.7
75
432
ZZA00
NOMESCO Finland
Split skin graft
15.2
6.5
10
7
SPAT1125
SPAT
Stoma care and guidance
15.2
6.5
10
7
QBB05
NOMESCO Finland
Revision of wound of skin of trunk
72.9
6.5
7
*
TJF80
NOMESCO Finland
Ostomy education
72.9
6.5
7
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
4.0
6.4
25
71
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.2
6.4
19
41
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.3
6.4
16
28
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
28.0
6.3
8
*
K62.9
ICD-10 Finland
Disease of anus and rectum, unspecified
28.0
6.3
8
*
Z51.0
ICD-10 Finland
Radiotherapy session
+∞
6.3
6
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
6.3
6
*
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
+∞
6.3
6
*
HAC20
NOMESCO Finland
Total mastectomy
+∞
6.3
6
*
JGB37
NOMESCO Finland
Laparoscopic wide excision of rectum
+∞
6.3
6
*
D37.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Digestive organ, unspecified
+∞
6.3
6
*
WB121
NOMESCO Finland
Demanding neoadjuvant cytostatic therapy
+∞
6.3
6
*
JG1CM
NOMESCO Finland
Extensive MRI of rectum (more than 1.5 T)
+∞
6.3
6
*
ZZR10
NOMESCO Finland
Flap of skin and muscle
+∞
6.3
6
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.0
6.2
38
153
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
6.6
6.2
15
25
D18
ICPC
Change in faeces/bowel movements
13.3
6.2
10
8
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
7.8
6.1
13
18

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
244
167
33.48
299.84
5.4
1.5
26.7
4.4
ug/l
0.51
206
130
114
88
17.41
124.59
1.4
1.3
—
—
—
0
0
154
339
6.59
71.83
2.4
1.3
—
—
—
0
0
62
72
9.93
50.39
5.0
1.9
85.8
13.4
u/ml
1.31
56
56
306
1558
4.55
44.99
12.3
3.6
9.8
11.6
umol/l
4.58
298
1459
230
1003
3.86
41.30
3.3
1.7
—
—
—
0
0
274
1345
3.98
41.10
8.7
3.5
33.2
35.5
g/l
8.09
266
1250
191
802
3.53
35.05
6.3
3.8
—
—
—
0
0
297
1650
3.73
34.50
15.9
6.2
3.8
4.3
e9/l
3.21
263
1437
201
890
3.41
33.55
4.3
2.0
—
—
—
0
0
124
426
3.71
30.46
4.2
2.6
0.8
0.8
mmol/l
4.94
118
394
171
724
3.30
30.09
5.3
3.2
92.9
87.7
%
1.73
171
700
87
237
4.37
29.54
1.5
1.1
—
—
—
0
0
163
682
3.27
29.09
4.1
2.0
—
—
—
0
0
210
1041
3.03
27.56
6.7
2.0
2.3
2.4
mmol/l
0.36
197
854
102
328
3.79
27.38
2.4
2.2
12.1
7.1
umol/l
0.61
81
283
246
1365
2.94
25.69
6.5
3.5
—
—
—
0
0
232
1328
2.67
21.54
11.8
10.1
1.2
1.3
inr
0.84
64
383
81
270
3.48
20.20
2.5
2.0
30.1
35.2
u/l
0.58
67
229
145
701
2.63
18.42
12.1
4.5
—
—
—
0
0
339
2444
3.01
18.41
15.2
5.2
89.7
76.3
u/l
3.85
331
2237
102
413
2.94
18.22
2.9
2.4
21.1
23.9
%
1.26
92
348
177
950
2.49
17.96
4.6
2.9
39.0
129.3
e6/l
0.68
138
725
159
824
2.50
17.27
4.5
2.7
—
—
—
0
0
163
865
2.45
16.70
4.6
2.8
0.5
0.4
e6/l
0.09
124
640
112
497
2.71
16.69
2.8
2.3
11.8
13.7
umol/l
2.12
107
454
109
487
2.67
15.96
3.1
2.8
2.2
2.4
e6/l
0.07
61
254
223
1379
2.32
15.85
6.4
5.5
9.2
8.5
%
2.10
209
1272
225
1400
2.31
15.72
6.3
5.4
22.3
27.4
%
8.85
209
1286
102
444
2.71
15.70
2.9
2.3
2.3
2.3
g/l
0.37
97
408
216
1325
2.30
15.57
5.9
5.3
0.6
0.7
%
1.36
202
1218
223
1389
2.29
15.46
5.7
5.2
60.4
57.5
%
2.75
209
1284
221
1372
2.29
15.43
6.0
5.2
2.8
2.9
%
0.26
208
1260
189
1107
2.29
15.09
5.4
3.5
163.4
94.7
e6/l
0.37
141
783
168
958
2.26
14.09
6.3
5.4
—
—
—
0
0
122
610
2.41
13.87
5.9
2.1
2.5
2.4
mmol/l
3.25
111
518
98
448
2.55
13.49
2.4
1.9
—
—
—
0
0
48
147
3.56
13.46
16.9
7.3
—
—
—
0
0
237
1597
2.11
12.53
12.1
5.2
1.2
1.2
mmol/l
1.35
202
1374
219
1445
2.08
12.12
10.8
4.7
1.2
1.2
mmol/l
0.55
204
1284
223
1489
2.06
11.86
6.0
5.1
0.6
0.6
e9/l
0.87
175
1279
224
1500
2.06
11.80
6.0
5.1
0.0
0.0
e9/l
1.52
176
1296
81
361
2.54
11.64
2.0
1.7
—
—
—
0
0
225
1515
2.04
11.61
6.1
5.2
1.5
1.8
e9/l
5.51
182
1328
229
1558
2.03
11.41
6.4
5.3
0.2
0.2
e9/l
0.20
187
1361
129
710
2.18
11.39
1.4
1.3
—
—
—
0
0
123
666
2.20
11.30
4.0
2.3
3.8
5.3
e6/l
1.52
111
579
154
916
2.08
11.04
7.8
2.9
7.4
7.4
ph
0.02
36
144
285
2114
2.08
10.99
6.1
4.4
3.6
3969.9
e6/l
—
5
36
65
274
2.62
10.42
1.5
1.4
66.5
67.2
g/l
0.32
60
243
140
830
2.03
9.95
2.5
2.1
3.5
3.1
mg/l
0.73
115
696
164
1032
1.97
9.81
3.7
2.1
57.7
58.2
u/l
0.06
154
952
112
617
2.11
9.66
4.2
2.5
488.9
542.4
mosm/kgh2o
2.29
101
514
58
240
2.64
9.63
17.0
6.0
—
—
—
0
0
288
2200
1.98
9.51
6.3
4.2
—
—
—
0
0
77
369
2.33
9.33
11.8
5.6
0.9
1.6
mmol/l
1.04
69
291
67
303
2.44
9.24
13.2
6.1
113.6
121.9
g/l
3.11
67
298
68
310
2.42
9.21
1.5
1.6
—
—
—
0
0
92
486
2.14
8.77
2.3
1.7
29.6
29.6
s
0.01
92
464
194
1337
1.84
8.45
3.2
2.7
195.4
130.3
ug/l
1.83
180
1219
35
124
2.99
7.74
1.9
1.6
6.1
1.8
ug/l
0.88
35
111
157
1045
1.80
7.44
3.9
3.0
—
—
—
0
0
76
397
2.12
7.39
2.1
2.2
1.8
1.8
%
0.04
67
358
188
1350
1.71
6.65
15.0
8.0
0.0
0.0
e9/l
0.52
138
1111
53
262
2.17
5.90
3.3
3.5
84.1
85.3
ng/l
0.04
43
229
44
206
2.27
5.58
3.3
4.0
0.8
0.3
%
1.24
16
41
46
226
2.16
5.20
3.5
4.0
0.7
0.8
%
0.20
21
50
9
9
10.19
5.05
2.8
1.6
—
—
—
0
0
16
46
3.58
4.94
6.4
3.1
59.9
61.1
%
0.13
16
46
8
8
10.16
4.53
1.4
1.0
—
—
—
0
0
21
77
2.82
4.42
5.8
2.4
—
—
—
0
0
41
206
2.10
4.39
3.5
4.1
0.1
2.1
%
0.48
19
41
15
45
3.42
4.36
5.7
2.6
4.0
4.7
e9/l
0.59
15
45
42
214
2.07
4.34
3.7
4.1
0.1
0.1
%
0.10
20
45
104
714
1.61
4.03
2.1
1.6
2.2
1.0
mg/l
0.66
84
544
94
637
1.61
3.83
5.5
4.1
—
—
—
0
0
52
300
1.84
3.77
2.9
2.4
64.0
68.6
e9/l
0.39
37
246
11
30
3.74
3.66
1.8
2.6
—
—
—
0
0
53
312
1.80
3.61
5.4
3.1
1.6
2.1
mmol/l
0.53
40
254
188
1501
1.46
3.51
2.2
2.1
90.0
95.6
pmol/l
0.92
105
751
15
54
2.84
3.29
1.0
1.3
—
—
—
0
0
296
3276
0.67
3.25
4.4
4.8
1.5
1.5
mmol/l
0.08
273
2970
287
3184
0.69
3.05
5.9
6.3
40.3
40.5
mmol/mol
0.09
257
2924
17
70
2.49
2.91
1.6
1.3
—
—
—
0
0
9
22
4.16
2.89
1.2
1.5
—
—
—
0
0
94
677
1.50
2.88
3.6
3.9
104.0
409.5
ng/l
1.70
79
557
8
18
4.51
2.81
3.4
1.8
3.7
3.6
nmol/l
—
8
18
40
235
1.78
2.77
1.9
1.5
—
—
—
0
0
21
98
2.20
2.75
1.4
1.3
35.5
43.9
mg/l
0.61
15
80
351
3229
1.53
2.67
32.7
12.6
30.5
23.2
mg/l
4.04
321
2497
9
227
0.38
2.64
1.4
1.3
—
—
—
0
0
100
746
1.45
2.55
1.8
1.8
1021.8
1203.3
nmol/l
1.14
77
557
31
173
1.86
2.54
2.7
2.7
0.4
0.2
e6/l
0.49
31
165
303
3300
0.71
2.53
4.4
4.8
4.7
4.6
mmol/l
0.22
282
3009
114
875
1.42
2.49
1.6
1.5
19.1
21.1
nmol/l
0.69
101
742
12
45
2.72
2.47
1.2
1.1
—
—
—
0
0
191
1601
1.35
2.43
4.9
3.7
0.0
0.0
estimate
0.50
39
262
41
253
1.69
2.41
1.6
1.4
—
—
—
0
0
188
1575
1.35
2.38
6.6
5.1
0.0
0.0
estimate
0.00
38
259
5
8
6.31
2.38
1.6
1.4
0.1
0.2
e9/l
—
5
8
20
98
2.09
2.35
1.5
1.3
33.4
30.2
mg/l
0.18
14
79
267
2365
1.35
2.31
4.2
4.0
—
—
—
0
0
278
2481
1.36
2.27
4.1
4.2
22.1
12.6
mm/h
8.07
261
2252
186
1567
1.34
2.23
4.9
3.8
0.0
0.0
estimate
0.00
38
266
43
275
1.63
2.22
1.5
1.5
—
—
—
0
0
8
24
3.38
2.19
3.5
3.0
—
—
—
0
0
25
137
1.88
2.18
1.5
1.3
—
—
—
0
0
15
68
2.25
2.13
1.5
1.2
—
—
—
0
0
98
757
1.38
2.04
3.6
3.7
—
—
—
0
0
5
11
4.59
1.94
1.0
1.3
—
—
—
0
0
8
27
3.00
1.94
1.4
1.0
—
—
—
0
0
16
78
2.09
1.93
3.8
3.4
—
—
—
0
0
307
3299
0.74
1.92
5.0
4.9
6.0
6.0
mmol/l
0.20
276
2963
50
344
1.51
1.91
1.9
2.0
212.5
137.6
ug/g
0.41
43
268
29
175
1.71
1.88
1.2
1.2
—
—
—
0
0
87
1107
0.73
1.86
2.8
3.1
—
—
—
0
0
6
17
3.56
1.84
1.8
2.4
—
—
—
0
0
293
3161
0.76
1.80
4.0
4.3
1.3
1.3
mmol/l
0.34
268
2845
33
209
1.63
1.80
5.9
3.0
4.4
3.9
e9/l
0.36
28
150
8
29
2.79
1.80
2.4
1.7
4.0
131.1
u/ml
—
8
29
13
60
2.20
1.79
9.9
2.9
—
—
—
0
0
9
36
2.53
1.75
4.0
1.5
88.9
90.8
%
—
9
36
133
1101
1.30
1.73
2.6
3.0
1351.8
1516.9
ng/l
0.17
123
933
5
13
3.88
1.72
1.0
1.2
—
—
—
0
0
36
237
1.57
1.69
1.4
1.4
—
—
—
0
0
317
3374
0.75
1.67
4.8
5.4
2.7
2.7
mmol/l
0.19
290
3066
8
31
2.61
1.66
2.6
2.1
—
—
—
0
0
11
49
2.28
1.65
7.9
2.5
—
—
—
0
0
5
14
3.60
1.62
3.6
2.7
—
—
—
0
0
36
241
1.54
1.58
7.8
3.5
—
—
—
0
0
18
100
1.84
1.55
1.3
1.7
—
—
—
0
0
20
115
1.78
1.55
1.2
1.2
—
—
—
0
0
10
44
2.30
1.54
2.3
2.3
30.2
33.8
pg
—
10
44
0
42
0.00
1.53
0.0
1.2
—
—
—
0
0
66
501
1.38
1.53
19.7
26.6
1.3
1.4
inr
0.12
12
66
310
2880
1.29
1.51
33.9
13.7
37.0
39.7
%
6.29
225
1915
9
37
2.46
1.48
1.0
1.2
—
—
—
0
0
12
59
2.06
1.45
4.8
2.6
—
—
—
0
0
8
163
0.48
1.39
1.3
1.5
—
—
—
0
0
44
317
1.43
1.38
2.6
3.4
141.5
218.4
ng/l
1.55
35
292
5
17
2.96
1.36
1.8
2.3
—
—
—
0
0
0
38
0.00
1.35
0.0
1.5
—
—
—
0
0
9
172
0.51
1.32
1.2
1.3
—
—
—
0
0
6
24
2.52
1.31
1.5
1.3
—
—
—
0
0
6
24
2.52
1.31
1.3
1.4
—
—
—
0
0
32
220
1.49
1.28
4.3
3.7
5.0
5.2
kpa
1.43
32
203
32
220
1.49
1.28
4.5
4.4
—
—
—
0
0
127
1085
1.24
1.24
2.1
2.1
182.7
276.1
u/l
0.62
122
1011
42
563
0.72
1.24
1.3
1.2
19.2
11.7
u/ml
0.19
15
197
8
37
2.18
1.22
1.8
1.2
32.2
26.1
g/l
—
8
32
5
19
2.65
1.22
3.4
1.9
—
—
—
0
0
5
20
2.52
1.15
6.2
15.1
—
—
—
0
0
7
30
2.36
1.13
1.3
1.1
—
—
—
0
0
7
31
2.28
1.11
1.4
1.2
—
—
—
0
0
5
22
2.29
1.03
1.0
1.1
—
—
—
0
0
49
384
1.31
0.96
1.4
1.4
—
—
—
0
0
43
331
1.33
0.96
5.3
3.8
—
—
—
0
0
6
120
0.49
0.95
1.7
1.1
—
—
—
0
0
24
335
0.70
0.92
1.8
1.5
—
—
—
0
0
6
28
2.16
0.92
1.2
1.3
—
—
—
0
0
6
29
2.08
0.89
1.7
1.6
9.4
10.8
%
—
6
29
8
43
1.88
0.87
1.1
1.0
—
—
—
0
0
12
72
1.69
0.86
4.7
1.9
122.6
133.3
g/l
—
7
55
8
45
1.79
0.84
1.0
1.1
—
—
—
0
0
6
32
1.89
0.82
3.7
2.7
749.2
530.4
ml
—
6
21
43
340
1.29
0.81
1.7
2.5
5.1
7.0
ug/l
0.59
37
288
23
165
1.42
0.79
3.3
3.8
—
—
—
0
0
0
24
0.00
0.79
0.0
2.0
—
2.3
—
0
18
19
132
1.46
0.77
1.3
1.2
—
—
—
0
0
48
583
0.80
0.73
1.4
1.3
37.7
39.4
iu/ml
0.04
15
184
5
25
2.01
0.73
4.0
2.4
504.8
481.9
min
—
5
18
9
56
1.62
0.73
1.1
1.5
—
—
—
0
0
7
41
1.72
0.70
7.9
4.6
6.5
7.4
mmol/l
—
7
32
10
61
1.65
0.69
7.5
2.1
15.4
16.6
%
—
5
31
355
3446
1.20
0.64
36.9
15.5
4.0
4.0
mmol/l
1.22
350
3328
5
29
1.73
0.64
3.0
3.8
—
—
—
0
0
95
843
1.16
0.62
5.5
3.4
—
—
—
0
0
16
217
0.73
0.56
1.3
1.5
—
—
—
0
0
6
37
1.63
0.55
1.2
1.3
—
—
—
0
0
348
3384
1.17
0.54
27.0
12.4
—
—
—
0
0
65
566
1.18
0.54
1.4
1.2
3.2
2.7
g/l
0.25
40
323
9
134
0.66
0.52
1.4
1.5
—
—
—
0
0
23
179
1.30
0.52
5.0
2.3
0.9
1.1
%
1.32
23
179
297
3072
0.89
0.51
5.4
4.7
2.0
2.4
mu/l
0.36
269
2760
7
46
1.53
0.48
1.4
1.1
—
—
—
0
0
5
32
1.57
0.42
1.6
1.1
—
—
—
0
0
10
70
1.44
0.42
1.3
1.1
—
—
—
0
0
5
33
1.52
0.41
1.6
1.2
—
—
—
0
0
18
141
1.29
0.41
3.8
4.3
24.0
24.8
mmol/l
0.57
18
133
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
5
34
1.48
0.40
1.4
1.1
—
—
—
0
0
5
34
1.48
0.40
1.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
3.4
—
30.2
—
0
13
0
19
0.00
0.39
0.0
1.2
—
44.6
—
0
6
13
98
1.34
0.38
8.2
4.7
—
—
—
0
0
5
37
1.36
0.37
1.2
1.2
—
—
—
0
0
19
232
0.81
0.34
1.1
1.1
—
—
—
0
0
6
45
1.34
0.34
1.3
1.3
—
—
—
0
0
85
783
1.11
0.33
1.6
1.8
380.2
18367795.5
pmol/l
0.80
70
637
21
250
0.83
0.31
2.9
2.5
—
10.9
—
0
5
86
925
0.91
0.30
1.6
1.6
1.6
1.4
mmol/l
1.32
74
766
7
57
1.23
0.29
2.1
2.3
—
—
—
0
0
23
195
1.19
0.29
2.5
2.4
—
—
—
0
0
14
112
1.26
0.28
1.2
1.4
1.3
1.2
g/l
0.73
14
106
9
118
0.76
0.27
17.6
10.9
—
—
—
0
0
8
65
1.24
0.27
1.4
1.1
—
—
—
0
0
70
756
0.91
0.27
5.0
4.1
1.0
1.0
kg/l
0.46
13
105
25
216
1.17
0.26
2.7
2.8
—
—
—
0
0
110
1161
0.93
0.25
3.7
3.1
7.0
7.2
mmol/l
0.20
99
967
5
38
1.32
0.23
1.6
3.3
—
—
—
0
0
5
39
1.29
0.23
2.8
2.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
0.7
—
0
5
353
3484
1.08
0.21
19.5
8.9
23.9
24.7
u/l
0.51
348
3312
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
432.3
—
0
12
6
48
1.25
0.20
2.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
28.3
—
0
9
10
81
1.24
0.19
3.2
3.4
26.2
29.9
mg/l
—
5
54
7
58
1.21
0.18
2.1
2.3
3.8
4.1
mmol/l
—
7
58
7
58
1.21
0.18
2.1
2.3
104.0
105.8
mmol/l
—
7
58
5
66
0.75
0.17
1.4
1.2
8.6
17.9
u/l
—
5
58
15
173
0.86
0.17
8.0
3.7
—
—
—
0
0
7
86
0.81
0.14
1.1
2.1
8.2
13.0
mg/l
—
7
80
144
1398
1.05
0.14
4.3
3.7
92.7
63.1
ng/l
0.20
110
1015
45
480
0.93
0.14
1.4
1.2
—
—
—
0
0
10
118
0.84
0.14
1.7
1.8
—
—
—
0
0
28
303
0.92
0.12
5.5
3.2
—
—
—
0
0
91
877
1.05
0.12
5.8
4.0
0.0
0.0
estimate
0.00
35
255
358
3608
0.95
0.12
46.4
18.8
6.5
6.7
e9/l
0.62
352
3473
358
3608
0.95
0.12
46.4
18.6
30.3
30.4
pg
0.42
353
3527
358
3608
0.95
0.12
46.4
18.7
4.1
4.5
e12/l
25.51
350
3473
21
191
1.10
0.12
1.0
1.2
98.5
133.4
iu/ml
—
8
76
11
126
0.87
0.11
3.4
1.9
—
—
—
0
0
358
3607
0.95
0.11
46.4
18.7
246.9
245.9
e9/l
0.08
350
3486
358
3607
0.95
0.11
46.4
18.7
92.0
91.4
fl
1.72
353
3526
12
105
1.15
0.11
1.5
1.6
—
—
—
0
0
26
241
1.08
0.10
1.3
1.4
—
—
—
0
0
116
1184
0.97
0.07
4.7
4.0
11.1
7.8
mg/mmol
0.57
81
744
15
138
1.09
0.06
4.1
4.3
—
—
—
0
0
106
1081
0.97
0.06
5.0
3.8
—
—
—
0
0
90
882
1.03
0.05
2.3
2.4
3522.8
7467.4
umol/l
0.54
77
745
253
2549
0.98
0.05
4.5
3.8
15.0
14.9
pmol/l
0.10
233
2288
11
119
0.92
0.04
1.3
1.2
—
0.2
—
0
11
68
670
1.02
0.02
1.1
1.2
0.5
1.6
u/ml
2.23
14
185
57
578
0.98
0.01
2.5
2.7
0.9
0.8
ug/l
0.15
31
390
112
1117
1.00
0.00
3.6
3.2
59.5
286.3
mg/l
1.24
83
696
106
1063
1.00
0.00
4.2
3.9
2.6
2.1
ug/l
0.27
83
935
40
404
0.99
0.00
1.3
1.3
742.2
441.9
titre
—
9
105
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
6.2
—
0
6
0
6
0.00
0.00
0.0
1.2
—
1.8
—
0
6
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
8
87
0.92
0.00
1.1
1.2
490.5
479.1
mg/l
—
8
80
5
51
0.98
0.00
1.0
1.4
59.0
64.4
pmol/l
—
5
51
0
6
0.00
0.00
0.0
1.5
—
19.4
—
0
6
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
7
75
0.93
0.00
1.1
1.2
4.1
4.0
mmol/l
—
7
69
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
5.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
3.7
—
14.2
—
0
9
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
0.00
1.2
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
3.1
—
—
—
0
0
7
74
0.95
0.00
1.7
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_ANUS_ANALCANAL_EXALLC – Malignant neoplasm of anus and anal canal, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).