Adenocarcinoma and Papillary adenocarcinoma of kidney, excluding all cancers (controls excluding all cancers)

C3_KIDNEY_PAPILLARYADENO_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 C64
  • Cancer registry: Morphology ICD-O-3 8260
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

345

4. Check minimum number of events

None

345

5. Include endpoints

None

345

6. Filter based on genotype QC (FinnGen only)

345

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Adenocarcinoma and Papillary adenocarcinoma of kidney, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 345 83 262
Unadjusted period prevalence (%) 0.09 0.03 0.12
Median age at first event (years) 67.04 67.58 66.87

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
322
Matched controls
3220
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8260/3-C64.9
ICD-O-3
Papillary adenocarcinoma, NOS, of kidney, NOS
+∞
323.0
322
*
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
+∞
323.0
311
*
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
1023.8
322.5
267
15
KAD00
NOMESCO Finland
Partial nephrectomy
557.9
88.7
84
*
B01AB10
ATC
tinzaparin; parenteral
28.3
78.1
109
57
KAD01
NOMESCO Finland
Percutaneous endoscopic partial nephrectomy
+∞
77.2
71
*
KAC10
NOMESCO Finland
Total nephrectomy with capsule
775.5
66.4
63
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
11.0
61.5
132
190
KAC11
NOMESCO Finland
Total nephrectomy with capsule, transcutaneous
656.3
57.5
55
*
JN4BD
NOMESCO Finland
Extensive body CT
18.8
57.1
91
66
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
17.6
53.4
87
66
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
49.4
53.4
64
16
JN4AD
NOMESCO Finland
Body CT examination
20.0
53.0
82
54
130
Kela drug reimbursment
Malignant tumour
+∞
52.5
49
*
WX408
NOMESCO Finland
General anesthesy, balanced
6.0
45.9
168
495
WX302
NOMESCO Finland
Thoracal epidural anesthesy
20.4
43.5
66
40
JN4CD
NOMESCO Finland
Very extensive body CT
27.4
41.4
57
25
C64
ICD-10 Finland
Malignant neoplasm of kidney, except renal pelvis
+∞
39.4
37
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
22.4
36.3
53
28
TPH07
NOMESCO Finland
Cathetrisation of artery
6.9
34.1
94
180
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.2
32.1
213
1026
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
14.5
29.8
51
41
B01AB05
ATC
enoxaparin; parenteral
4.1
28.1
147
550
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
8.0
27.6
66
100
C61
ICD-10 Finland
Malignant neoplasm of prostate
105.8
27.1
29
*
N02AX02
ATC
tramadol; systemic, rectal
3.6
26.5
197
975
WX402
NOMESCO Finland
General anaesthesia
5.0
25.0
90
230
R4110
NOMESCO Finland
Physiotherapy
3.7
24.3
136
526
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
24.3
23
*
JN3AD
NOMESCO Finland
Abdominal CT examination
6.7
24.0
65
117
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
12.5
20.0
36
32
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
12.5
19.0
34
30
197
Kela drug reimbursment
Sunitinib
+∞
18.9
18
*
N18.8
ICD-10 Finland
Other chronic renal failure
10.2
18.2
36
39
N02BE01
ATC
paracetamol; systemic, rectal
4.7
18.1
297
2299
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
9.6
18.0
37
43
U75
ICPC
Malignant neoplasm of kidney
+∞
17.9
17
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.7
17.0
62
156
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
16.2
17.0
27
18
L01XE04
ATC
[U] sunitinib; oral
+∞
16.8
16
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
16.8
16
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
178.7
16.6
17
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.7
16.5
81
268
U14
ICPC
Kidney symptom/complaint
16.5
16.5
26
17
205
Kela drug reimbursment
Chronic hypertension
2.8
16.3
149
759
D30.0
ICD-10 Finland
Benign neoplasm: Kidney
35.3
15.9
20
6
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
5.9
15.9
46
89
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
15.7
15
*
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
+∞
15.7
15
*
A11CC03
ATC
alfacalcidol; systemic
10.5
15.5
30
31
UKC02
NOMESCO Finland
Cystoscopy
3.4
15.3
86
313
A12AA04
ATC
calcium carbonate; oral
14.9
15.3
25
18
TK800
NOMESCO Finland
Hemodialysis
10.5
15.0
29
30
JN1CD
NOMESCO Finland
Very extensive CT examination of upper part of abdomen
28.7
14.4
19
7
H02AB02
ATC
dexamethasone; systemic
20.3
14.4
21
11
KA3LT
NOMESCO Finland
Njurlesion coagulation
+∞
13.6
13
*
WZC30
NOMESCO Finland
Teaching
3.9
13.6
59
174
C08CA01
ATC
amlodipine; oral
2.5
13.4
162
938
N28.1
ICD-10 Finland
Cyst of kidney
12.9
13.3
23
19
127
Kela drug reimbursment
Transplant complication
17.6
13.1
20
12
ZXC96
NOMESCO Finland
Robot assisted procedure
23.7
13.0
18
8
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.8
12.9
101
454
A03FA01
ATC
metoclopramide; systemic, rectal
3.8
12.7
56
167
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
12.6
12
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
15.1
12.4
20
14
Z94.0
ICD-10 Finland
Kidney transplant status
13.2
11.8
20
16
KAC00
NOMESCO Finland
Nephrectomy
67.4
11.7
13
*
JN3KE
NOMESCO Finland
Abdominal ultrasound with added contrast
67.4
11.7
13
*
137
Kela drug reimbursment
Uraemia requiring dialysis
23.9
11.7
16
7
V03AE01
ATC
polystyrene sulfonate; oral
14.3
11.6
19
14
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
5.2
11.6
36
76
116
Kela drug reimbursment
Prostate cancer
+∞
11.5
11
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
11.5
11
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
124.1
11.5
12
*
B03XA02
ATC
darbepoetin alfa; parenteral
10.2
11.4
22
23
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.8
11.4
38
87
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.1
11.4
45
122
J01MA02
ATC
ciprofloxacin; systemic
2.3
11.3
147
856
H05BX01
ATC
cinacalcet; oral
26.1
11.2
15
6
WX110
NOMESCO Finland
Local anesthesy
2.3
10.9
219
1553
M04AA01
ATC
allopurinol; systemic
2.9
10.9
75
308
Z49.0
ICD-10 Finland
Preparatory care for dialysis
18.6
10.8
16
9
A04AA02
ATC
granisetron; systemic, transdermal
62.0
10.7
12
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
10.6
10.7
20
20
KAC01
NOMESCO Finland
Percutaneous endoscopic nephrectomy
+∞
10.5
10
*
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.7
10.2
79
345
S18
ICPC
Laceration/cut
2.2
10.1
157
979
WF002
NOMESCO Finland
Radical radiotherapy
41.4
10.0
12
*
N02AA05
ATC
oxycodone; systemic
3.2
9.9
54
189
L04AA06
ATC
mycophenolic acid; systemic
11.9
9.7
17
15
KH1CD
NOMESCO Finland
Very extensive urinary tract ultrasound examination
18.2
9.5
14
8
D41.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Renal pelvis
102.8
9.5
10
*
196
Kela drug reimbursment
Paricalcitol and cinacalcet
22.5
9.4
13
6
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
9.4
9
*
158
Kela drug reimbursment
Everolimus
+∞
9.4
9
*
1502
Kela drug reimbursment
Cabozantinib
+∞
9.4
9
*
159
Kela drug reimbursment
Pazopanib
+∞
9.4
9
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
9.4
9
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
9.4
9
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
9.4
9
*
KA3CT
NOMESCO Finland
Biopsy of kidney under CT guidance
+∞
9.4
9
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
9.3
84
401
I10
ICD-10 Finland
Essential (primary) hypertension
2.1
9.3
226
1682
KE1AT
NOMESCO Finland
Biopsy of prostata with ultrasoudnguidance
5.9
9.3
25
45
R31
ICD-10 Finland
Unspecified haematuria
3.0
9.2
56
212
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
16.2
9.1
14
9
JN3CG
NOMESCO Finland
Extensive MRI examination of abdomen with high intensity magnet
37.8
9.1
11
*
Z51.5
ICD-10 Finland
Palliative care
7.2
9.0
21
31
XX3DW
NOMESCO Finland
Time consuming IT work
4.5
9.0
31
74
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
8.9
95
492
WW500
NOMESCO Finland
Blood transfusion
8.0
8.8
19
25
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
12.0
8.7
15
13
C08CA02
ATC
felodipine; oral
2.9
8.5
52
198
J01MA12
ATC
levofloxacin; systemic
2.5
8.4
74
346
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
+∞
8.4
8
*
KB1CG
NOMESCO Finland
Extensive MRI examination of urinary tract with high intensity magnet
+∞
8.4
8
*
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.6
8.3
68
305
ZXA05
NOMESCO Finland
Left side
2.2
8.2
100
547
GD1AD
NOMESCO Finland
Thorax CT examination
4.9
8.2
26
57
B05DA
ATC
Isotonic solutions
17.7
8.1
12
7
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
17.7
8.1
12
7
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
10.4
8.1
15
15
R74.8
ICD-10 Finland
Abnormal levels of other serum enzymes
4.8
8.1
26
58
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
22.7
8.1
11
5
ZXA00
NOMESCO Finland
Right side
2.1
8.0
102
572
L04AA01
ATC
[U] ciclosporin; systemic
13.5
7.9
13
10
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
13.5
7.9
13
10
N18.0
ICD-10 Finland
End-stage renal disease
8.8
7.9
16
19
SPAT1153
SPAT
Removal of sutures
2.1
7.8
117
699
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
15.5
7.8
12
8
G04CA02
ATC
tamsulosin; oral
2.0
7.6
120
729
UJF32
NOMESCO Finland
Coloscopy
2.2
7.5
90
489
ZX090
NOMESCO Finland
Other technic of radiotherapy
81.8
7.4
8
*
KH1BD
NOMESCO Finland
Extensive urinary tract CT examination
11.2
7.4
13
12
322
Kela drug reimbursment
Sunitinib
+∞
7.3
7
*
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
+∞
7.3
7
*
3012
Kela drug reimbursment
Cabozantinib
+∞
7.3
7
*
L01XE11
ATC
[U] pazopanib; oral
+∞
7.3
7
*
N02AJ06
ATC
codeine and paracetamol; systemic
2.0
7.3
123
763
D41.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bladder
16.2
7.3
11
7
R93.4
ICD-10 Finland
Abnormal findings on diagnostic imaging of urinary organs
16.2
7.3
11
7
A02BC02
ATC
pantoprazole; systemic
1.9
7.2
209
1580
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.3
7.2
71
351
L02AE02
ATC
leuprorelin; implant, parenteral
30.7
7.2
9
*
XKD00
NOMESCO Finland
Uroflowmetry
2.2
7.0
76
395
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
6.9
106
635
Z49.2
ICD-10 Finland
Other dialysis
17.1
6.8
10
6
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.9
6.8
42
160
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
23.0
6.7
9
*
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
8.1
6.7
14
18
JN1BD
NOMESCO Finland
Extensive CT examination of upper part of abdomen
12.6
6.6
11
9
KH1AD
NOMESCO Finland
CT of urinary organs
5.5
6.6
18
34
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
6.5
102
612
C02AC05
ATC
moxonidine; oral
3.2
6.5
32
106
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.9
6.4
40
152
321
Kela drug reimbursment
Paricalcitol and cinacalcet
18.4
6.3
9
5
168
Kela drug reimbursment
Axitinib
+∞
6.3
6
*
C64.80
ICD-10 Finland
Wilms tumour
+∞
6.3
6
*
L01XE17
ATC
[U] axitinib; oral
+∞
6.3
6
*
C67.9
ICD-10 Finland
Malignant neoplasm: Bladder, unspecified
+∞
6.3
6
*
C34.12
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary adenocarcinoma
+∞
6.3
6
*
KB1DG
NOMESCO Finland
Very extensive MRI of urinary tract
+∞
6.3
6
*
L01XE26
ATC
[U] cabozantinib; oral
+∞
6.3
6
*
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
27.2
6.3
8
*
-62
ICPC
Administrative procedure
5.9
6.2
16
28
J01CA04
ATC
amoxicillin; systemic
1.9
6.2
242
1971
L04AD01
ATC
ciclosporin; systemic
7.9
6.2
13
17
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
12.8
6.1
10
8
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.5
6.1
50
224
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.7
6.1
25
72

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
92
84
14.57
90.64
1.3
1.2
—
—
—
0
0
204
786
4.90
47.52
2.9
2.2
—
—
—
0
0
85
158
6.81
46.25
8.6
10.1
—
—
—
0
0
251
1174
5.18
44.44
5.0
3.6
—
—
—
0
0
106
255
5.56
43.74
12.9
6.7
12.4
10.8
mmol/l
1.37
100
240
106
258
5.49
43.10
10.8
7.8
—
—
—
0
0
65
98
7.94
42.81
2.3
2.5
0.2
0.2
g/l
0.22
41
38
197
787
4.50
42.55
2.8
1.6
—
—
—
0
0
189
735
4.48
42.29
5.8
2.7
—
—
—
0
0
244
1152
4.82
41.71
9.1
3.8
34.8
35.5
g/l
1.00
226
1061
203
845
4.41
41.06
6.3
2.9
23.7
143.2
e6/l
0.87
182
635
166
602
4.39
40.50
2.8
2.2
—
—
—
0
0
192
774
4.34
40.45
6.0
2.8
0.2
0.4
e6/l
2.35
170
565
159
568
4.34
39.40
4.5
2.2
2.8
3.8
e6/l
1.10
148
484
152
538
4.26
37.89
4.8
2.4
551.0
568.1
mosm/kgh2o
0.49
140
434
123
373
4.57
37.73
15.1
5.3
1.1
1.0
mmol/l
2.85
117
341
88
207
5.36
36.77
9.2
4.2
162.2
94.3
ng/l
3.81
81
183
75
157
5.83
35.61
9.5
9.7
23.0
24.8
mmol/l
7.25
75
144
208
960
3.94
34.55
7.3
3.5
45.7
74.8
e6/l
0.73
182
679
242
1238
4.20
34.49
15.3
5.4
1.2
1.2
mmol/l
0.13
227
1115
121
392
4.21
33.50
10.2
6.5
104.5
104.3
mmol/l
0.26
121
382
131
457
4.01
32.57
4.9
2.9
0.8
1.5
e6/l
0.97
79
251
311
2070
6.10
27.34
12.6
5.5
80.8
75.4
u/l
1.76
300
1905
238
1345
3.48
26.08
17.1
5.9
1.2
1.2
mmol/l
0.05
205
1170
289
1857
4.43
25.71
6.3
3.9
—
—
—
0
0
105
366
3.69
25.36
10.2
7.1
-1.1
1.4
mmol/l
9.98
93
281
219
1209
3.22
24.32
8.8
9.6
1.2
1.3
inr
1.12
49
321
164
772
3.14
24.02
11.5
3.2
7.4
7.4
ph
0.43
28
118
163
788
3.03
22.42
5.6
4.1
—
—
—
0
0
70
209
3.95
20.88
1.3
1.1
—
—
—
0
0
238
1453
3.06
20.75
10.0
5.9
4.7
4.4
e9/l
0.79
203
1273
166
848
2.85
20.08
5.4
5.7
—
—
—
0
0
95
357
3.29
19.90
6.5
2.5
20.9
24.6
%
1.95
81
300
165
848
2.81
19.62
5.0
2.1
2.4
2.3
mmol/l
0.82
143
691
97
373
3.23
19.52
6.3
2.5
2.2
2.2
g/l
0.46
89
345
147
715
2.84
19.38
3.0
3.2
—
—
—
0
0
53
138
4.36
18.94
3.5
1.5
3.2
5.0
ug/l
0.39
44
106
219
1330
2.77
18.35
8.4
4.0
10.5
12.6
umol/l
2.09
208
1253
259
1717
3.04
18.31
8.1
4.4
6.7
6.8
mmol/l
0.36
252
1610
126
594
2.77
17.28
5.8
4.6
—
—
—
0
0
155
842
2.53
15.60
4.3
2.4
389.2
6308.1
umol/l
2.98
138
727
109
503
2.71
15.32
3.7
2.2
2.5
2.4
mmol/l
1.88
90
419
97
425
2.78
15.05
6.4
2.4
10.9
13.5
umol/l
3.56
90
388
188
1172
2.33
13.26
5.9
5.4
0.7
0.7
%
0.22
176
1098
90
404
2.66
13.14
4.4
2.7
0.8
0.8
mmol/l
0.62
85
376
190
1214
2.26
12.33
6.2
5.7
9.0
8.8
%
0.47
176
1139
189
1209
2.25
12.18
5.9
5.5
2.9
3.1
%
0.69
176
1134
191
1235
2.22
11.89
6.1
5.6
23.2
26.7
%
4.39
176
1147
52
182
3.19
11.89
2.9
1.4
—
—
—
0
0
189
1228
2.19
11.49
5.9
5.4
61.7
57.8
%
4.39
176
1153
71
302
2.70
11.41
8.0
3.3
1.1
2.3
mmol/l
2.49
63
247
71
303
2.69
11.33
8.0
3.4
5.8
5.8
kpa
0.20
71
292
200
1343
2.16
11.01
6.4
5.4
0.2
0.2
e9/l
0.23
175
1190
38
116
3.56
10.76
2.9
1.8
—
—
—
0
0
195
1313
2.12
10.46
6.1
5.3
0.0
0.0
e9/l
0.26
163
1147
194
1308
2.10
10.32
6.1
5.2
0.7
0.6
e9/l
1.42
161
1135
195
1327
2.08
10.00
6.2
5.3
1.7
1.8
e9/l
0.84
167
1171
64
286
2.52
9.20
3.1
1.6
—
—
—
0
0
38
132
3.11
8.75
1.9
1.6
2.0
1.5
g/l
1.55
31
113
29
85
3.63
8.70
3.6
3.1
—
—
—
0
0
15
26
5.99
8.40
2.2
1.1
—
—
—
0
0
264
2079
2.15
8.35
5.5
4.0
17.4
11.8
mm/h
3.65
241
1890
319
2748
3.13
7.90
28.0
13.2
37.9
26.2
mg/l
5.19
291
2124
134
851
1.94
7.82
3.1
2.2
61.2
56.9
u/l
0.76
121
791
156
1043
1.90
7.79
5.4
2.6
211.4
156.0
ug/l
1.01
149
951
159
1073
1.89
7.69
4.8
3.3
7.1
8.2
mmol/l
3.60
133
884
36
133
2.91
7.45
1.5
1.5
—
—
—
0
0
111
672
1.96
7.39
2.5
2.0
3.3
3.0
mg/l
0.55
98
568
182
1299
1.85
7.24
4.6
3.4
0.0
0.0
estimate
0.00
39
205
55
256
2.37
7.17
1.3
1.3
—
—
—
0
0
50
224
2.44
7.09
3.4
1.6
—
—
—
0
0
49
218
2.45
7.05
3.7
1.4
—
—
—
0
0
18
44
4.26
6.90
7.6
2.1
—
—
—
0
0
153
1047
1.83
6.87
5.3
3.4
411.5
168.5
mg/l
0.37
121
702
19
49
4.05
6.80
5.1
3.0
—
—
—
0
0
20
54
3.87
6.74
4.0
1.2
—
—
—
0
0
67
348
2.15
6.71
2.4
2.1
1.8
1.7
%
0.63
62
309
14
29
4.99
6.51
1.2
1.1
—
—
—
0
0
107
664
1.89
6.49
1.4
1.3
—
—
—
0
0
181
1324
1.77
6.34
4.8
3.4
0.0
0.0
estimate
0.50
39
197
157
1105
1.77
6.26
5.8
4.1
24.2
8.1
mg/mmol
3.14
120
724
53
258
2.25
6.21
2.4
2.2
64.2
66.8
e9/l
0.24
38
196
178
1301
1.76
6.21
6.2
4.6
0.0
0.0
estimate
0.00
39
206
52
254
2.23
6.04
5.4
2.7
5.1
4.6
kpa
0.92
52
242
98
616
1.83
5.60
4.3
3.8
242.1
393.4
ng/l
0.37
88
519
13
30
4.46
5.34
1.2
1.3
—
—
—
0
0
12
26
4.75
5.30
1.5
1.2
—
—
—
0
0
53
277
2.08
5.19
2.4
2.2
7.7
8.3
umol/l
0.09
46
247
8
6
13.61
5.10
8.8
6.0
5.6
6.9
mmol/l
—
8
6
12
27
4.57
5.07
1.2
1.3
—
—
—
0
0
159
1179
1.65
4.88
13.4
8.0
0.0
0.0
e9/l
0.61
126
969
8
7
11.66
4.80
1.4
1.0
—
—
—
0
0
72
431
1.85
4.75
2.3
2.0
—
—
—
0
0
22
80
2.87
4.71
4.3
2.7
—
—
—
0
0
14
38
3.80
4.69
3.2
1.2
—
—
—
0
0
50
268
2.01
4.57
8.6
3.8
—
—
—
0
0
325
2973
2.61
4.44
38.0
16.3
139.1
139.7
mmol/l
4.51
316
2888
96
637
1.70
4.44
4.3
3.4
—
—
—
0
0
24
95
2.64
4.40
2.5
1.7
0.4
1.7
ug/l
1.44
18
86
7
6
11.87
4.29
3.4
2.0
—
—
—
0
0
325
2983
2.54
4.22
38.6
16.4
4.1
4.0
mmol/l
5.44
316
2896
284
2488
1.80
4.21
33.5
14.3
38.3
40.6
%
4.12
204
1657
61
361
1.84
4.15
1.2
1.2
—
—
—
0
0
164
1261
1.57
4.12
2.2
2.1
97.3
93.6
pmol/l
0.30
84
662
8
10
8.16
4.08
1.0
1.0
—
—
—
0
0
38
194
2.08
3.96
5.3
4.2
7.4
7.4
ph
—
5
18
6
5
12.18
3.77
5.8
1.4
—
—
—
0
0
16
56
2.95
3.68
1.1
1.2
—
—
—
0
0
38
201
2.00
3.61
7.2
3.0
—
—
—
0
0
6
6
10.15
3.51
1.0
1.3
—
—
—
0
0
6
6
10.15
3.51
1.0
1.0
—
—
—
0
0
245
2106
1.56
3.46
4.9
4.2
—
—
—
0
0
13
42
3.18
3.40
1.4
1.1
—
—
—
0
0
15
53
2.91
3.40
6.3
2.7
1.2
2.4
mmol/l
—
9
31
9
18
5.10
3.39
1.0
1.2
—
—
—
0
0
13
43
3.10
3.28
1.1
1.2
—
—
—
0
0
130
988
1.51
3.25
3.2
2.7
0.8
0.7
ug/l
0.29
105
673
83
572
1.59
3.22
1.5
1.7
1.2
1.3
mg/l
0.24
64
446
8
15
5.43
3.21
1.1
1.1
—
—
—
0
0
30
153
2.05
3.16
5.4
4.3
—
—
—
0
0
27
133
2.12
3.11
6.1
4.6
24.3
24.9
mmol/l
0.42
21
124
14
51
2.82
3.02
2.3
2.5
17.1
16.8
%
—
7
24
315
2918
1.91
2.97
29.0
12.4
—
—
—
0
0
207
1746
1.46
2.97
5.1
3.9
2.2
2.0
ug/l
0.54
195
1565
41
240
1.80
2.90
2.1
2.5
161.9
140.8
ug/g
0.16
34
190
6
9
6.76
2.88
1.0
1.2
—
—
—
0
0
15
60
2.57
2.74
1.5
1.3
324.0
323.2
ug/g
—
8
38
321
3005
1.98
2.73
37.6
15.7
127.3
84.9
umol/l
11.81
321
3005
101
760
1.47
2.56
1.9
1.5
19.3
20.4
nmol/l
0.28
95
642
14
56
2.56
2.56
1.7
1.1
—
—
—
0
0
70
958
0.66
2.45
2.8
3.2
—
—
—
0
0
19
90
2.18
2.43
2.5
1.5
—
—
—
0
0
12
46
2.67
2.38
1.0
2.0
—
—
—
0
0
319
3002
1.83
2.34
15.6
9.1
24.9
27.0
u/l
2.06
305
2879
39
241
1.70
2.32
4.9
3.0
—
—
—
0
0
6
13
4.68
2.28
1.3
1.2
—
—
—
0
0
0
60
0.00
2.27
0.0
4.7
—
23.7
—
0
42
6
15
4.05
2.04
2.0
2.3
—
—
—
0
0
6
15
4.05
2.04
1.0
1.1
—
—
—
0
0
34
210
1.69
2.04
10.3
4.7
—
—
—
0
0
15
70
2.19
2.01
1.3
3.0
29.2
34.4
umol/l
—
9
61
13
57
2.33
2.00
2.9
3.2
7.8
7.9
kpa
0.04
13
51
325
3100
1.83
1.91
44.2
19.2
251.1
236.7
e9/l
3.13
319
3007
325
3101
1.83
1.89
44.3
19.2
7.4
6.7
e9/l
7.30
318
2996
325
3101
1.83
1.89
44.2
19.2
4.4
4.6
e12/l
8.76
318
2990
6
17
3.57
1.84
1.0
1.2
—
—
—
0
0
63
463
1.44
1.78
1.3
1.2
1.7
1.5
u/ml
0.06
13
133
6
18
3.37
1.75
3.7
2.5
—
—
—
0
0
87
684
1.36
1.67
4.4
3.1
—
—
—
0
0
6
20
3.03
1.58
1.3
1.4
12.3
15.8
ug/l
—
6
20
32
209
1.59
1.58
1.3
1.4
—
—
—
0
0
5
15
3.37
1.53
1.2
1.6
—
1766.8
—
0
5
218
1968
1.29
1.50
4.2
3.3
14.9
15.0
pmol/l
0.12
192
1762
18
102
1.81
1.48
3.8
2.2
215.5
78.7
ug/min
0.50
13
59
7
28
2.53
1.46
1.6
1.4
—
—
—
0
0
7
28
2.53
1.46
1.6
1.4
—
—
—
0
0
7
28
2.53
1.46
1.6
1.4
—
—
—
0
0
7
28
2.53
1.46
1.6
1.4
—
—
—
0
0
6
22
2.76
1.44
1.0
1.1
—
—
—
0
0
9
40
2.28
1.41
2.2
2.5
4.8
4.6
e9/l
—
9
40
9
41
2.23
1.38
2.3
3.0
61.9
58.7
%
—
9
41
6
23
2.64
1.37
1.0
1.1
—
—
—
0
0
23
145
1.63
1.33
1.1
1.3
—
—
—
0
0
10
48
2.12
1.29
2.9
3.3
—
—
—
0
0
10
48
2.12
1.29
1.1
1.6
—
—
—
0
0
26
171
1.56
1.27
3.5
3.0
5.9
4.3
e9/l
0.62
17
124
17
100
1.74
1.26
2.2
1.7
—
—
—
0
0
6
25
2.42
1.25
4.5
4.0
—
—
—
0
0
19
116
1.68
1.24
1.2
1.2
—
—
—
0
0
268
2513
1.30
1.21
4.9
4.1
2.2
2.0
mu/l
0.44
242
2264
8
38
2.13
1.19
1.1
1.6
—
—
—
0
0
6
26
2.33
1.19
3.8
2.7
—
—
—
0
0
45
337
1.39
1.18
2.1
1.7
—
—
—
0
0
58
453
1.34
1.17
41.4
25.0
1.2
1.3
inr
—
8
63
37
270
1.41
1.12
1.5
1.4
—
—
—
0
0
13
73
1.81
1.12
3.1
3.2
23.2
25.0
mmol/l
1.15
13
63
72
585
1.29
1.10
1.9
1.8
1510.7
1126.4
nmol/l
0.82
52
444
106
904
1.25
1.09
4.6
4.0
—
—
—
0
0
96
813
1.25
1.05
1.8
1.7
1.6
1.3
mmol/l
2.25
86
660
56
444
1.31
1.03
1.4
1.2
2.2
2.9
g/l
2.50
34
254
7
133
0.52
1.01
2.1
1.4
—
—
—
0
0
22
148
1.52
1.00
2.6
1.3
4.0
1.1
g/l
0.72
22
138
6
27
2.24
0.94
1.0
1.1
—
—
—
0
0
10
55
1.84
0.93
1.7
1.8
237.7
276.0
mu/l
—
10
49
6
28
2.16
0.92
3.3
1.5
10.7
10.7
%
—
6
28
11
63
1.77
0.91
1.3
1.4
11.0
4.9
u/l
0.69
11
52
136
1212
1.20
0.90
4.3
3.8
44.8
108.7
ng/l
0.87
102
905
6
30
2.02
0.87
1.0
1.0
—
—
—
0
0
23
163
1.44
0.84
7.3
2.7
23.9
25.2
mmol/l
1.19
23
158
44
348
1.30
0.84
2.0
1.5
—
—
—
0
0
6
32
1.89
0.82
2.2
1.3
—
—
—
0
0
0
24
0.00
0.79
0.0
2.0
—
—
—
0
0
17
115
1.50
0.78
1.2
1.2
103.4
109.3
iu/ml
—
5
43
21
151
1.42
0.73
1.9
2.4
—
—
—
0
0
9
56
1.62
0.73
2.2
1.8
—
—
—
0
0
7
39
1.81
0.73
1.1
1.5
—
—
nmol/l
—
0
0
5
30
1.68
0.61
1.0
1.3
—
—
—
0
0
39
320
1.25
0.59
2.7
2.8
5.9
8.3
ug/l
0.81
34
281
8
53
1.52
0.59
1.5
3.0
—
—
—
0
0
0
23
0.00
0.58
0.0
1.8
—
—
—
0
0
33
404
0.80
0.57
1.2
1.3
34.5
7.4
u/ml
—
9
140
6
36
1.68
0.57
3.8
2.8
—
—
—
0
0
10
65
1.55
0.56
1.1
1.5
—
—
—
0
0
291
2825
1.19
0.54
5.3
5.0
6.2
6.1
mmol/l
0.24
255
2556
79
702
1.16
0.53
6.1
3.5
0.1
0.0
estimate
0.49
36
200
26
324
0.79
0.52
1.5
1.5
—
—
—
0
0
284
2754
1.18
0.52
7.6
6.6
40.7
40.8
mmol/mol
0.06
255
2542
14
189
0.73
0.49
1.2
1.4
—
—
—
0
0
5
83
0.60
0.46
1.0
1.6
—
—
—
0
0
15
113
1.34
0.43
1.1
1.2
—
—
—
0
0
5
32
1.57
0.42
1.4
1.3
—
—
—
0
0
299
2924
1.17
0.41
5.7
5.5
2.4
2.6
mmol/l
2.32
267
2685
0
16
0.00
0.41
0.0
3.6
—
32.8
—
0
9
0
16
0.00
0.41
0.0
1.1
—
137.0
—
0
16
11
79
1.41
0.41
1.6
1.6
—
—
—
0
0
293
2862
1.16
0.41
5.1
4.9
4.3
4.4
mmol/l
1.20
260
2640
7
102
0.68
0.40
38.9
13.8
—
—
—
0
0
0
18
0.00
0.40
0.0
2.7
—
—
—
0
0
55
618
0.87
0.40
5.7
3.7
1.0
1.0
kg/l
—
8
81
21
169
1.26
0.39
1.2
1.2
—
—
—
0
0
5
35
1.43
0.39
1.0
1.0
1.7
1.5
g/l
—
5
29
0
19
0.00
0.39
0.0
1.5
—
15.3
—
0
19
9
66
1.37
0.38
1.1
1.1
—
105.0
—
0
6
38
436
0.86
0.36
1.2
1.3
137.1
31.1
iu/ml
0.87
11
125
34
292
1.18
0.36
1.9
2.4
12.0
15.1
nmol/l
1.83
29
254
5
80
0.62
0.35
7.0
4.2
—
—
—
0
0
102
948
1.11
0.35
2.3
2.2
127.3
312.9
u/l
1.59
96
880
21
177
1.20
0.28
3.9
2.8
—
—
—
0
0
16
132
1.22
0.26
12.2
4.3
—
—
—
0
0
9
72
1.26
0.26
1.3
1.1
—
—
—
0
0
280
2751
1.09
0.24
4.5
4.4
1.5
1.3
mmol/l
3.32
238
2505
5
38
1.32
0.23
1.2
1.1
—
—
—
0
0
5
40
1.25
0.22
1.0
1.1
—
—
—
0
0
288
2836
1.09
0.22
5.1
4.9
1.3
1.4
mmol/l
2.63
257
2597
0
10
0.00
0.21
0.0
11.8
—
796.0
—
0
10
0
10
0.00
0.21
0.0
12.3
—
1654.9
—
0
10
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
6.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.1
—
1271.0
—
0
5
0
12
0.00
0.21
0.0
1.2
—
4.6
—
0
6
5
43
1.17
0.21
1.4
2.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
6
51
1.18
0.19
3.8
2.5
—
—
—
0
0
6
51
1.18
0.19
3.8
2.5
—
—
—
0
0
6
52
1.16
0.19
3.8
1.7
—
—
—
0
0
6
53
1.13
0.19
3.8
2.4
—
—
—
0
0
6
53
1.13
0.19
3.8
2.4
—
—
—
0
0
11
132
0.83
0.18
1.4
1.9
44.1
41.2
nmol/l
0.14
11
125
7
89
0.78
0.14
1.1
1.1
—
—
—
0
0
12
104
1.16
0.12
10.8
4.8
4.0
4.0
mmol/l
0.09
12
98
11
95
1.16
0.12
1.5
1.8
—
—
—
0
0
14
125
1.13
0.10
1.0
1.1
—
—
—
0
0
5
45
1.11
0.10
1.0
1.1
—
—
—
0
0
15
136
1.11
0.08
1.6
1.3
—
—
—
0
0
18
194
0.92
0.07
2.4
2.6
—
14.6
—
0
7
56
544
1.04
0.05
5.7
3.7
—
—
—
0
0
18
191
0.94
0.05
3.4
3.6
0.9
0.8
%
—
6
46
66
651
1.02
0.02
1.9
1.7
468.5
18199291.8
pmol/l
0.79
53
533
16
167
0.96
0.01
1.2
1.4
—
53.5
—
0
9
15
148
1.01
0.00
3.7
3.4
—
—
—
0
0
6
68
0.88
0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
0.2
—
0
9
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
6.4
—
0
5
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
63.4
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
12.1
—
0.7
—
0
7
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
8.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
15.3
—
0
6
6
67
0.89
0.00
1.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
5.7
—
22.2
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_KIDNEY_PAPILLARYADENO_EXALLC – Adenocarcinoma and Papillary adenocarcinoma of kidney, excluding all cancers (controls excluding all cancers)

GWS hits: 1

This endpoint is excluded (different definition than used in FinnGen).