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Malignant neoplasm of other and unspecified parts of mouth, excluding all cancers (controls excluding all cancers)

C3_MOUTHNAS_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C06
  • Hospital discharge: ICD-9 145
  • Hospital discharge: ICD-8 145
  • Cause of death: ICD-10 C06
  • Cause of death: ICD-9 145
  • Cause of death: ICD-8 145
  • Cause of death: excluded ICD-8 1451
  • Cancer registry: Topography ICD-O-3 C06
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

293

4. Check minimum number of events

None

293

5. Include endpoints

None

293

6. Filter based on genotype QC (FinnGen only)

293

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of other and unspecified parts of mouth, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 293 149 144
Unadjusted period prevalence (%) 0.06 0.05 0.06
Median age at first event (years) 66.36 68.10 64.56

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
175
Matched controls
1751
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C06.0
ICD-10 Finland
Malignant neoplasm: Cheek mucosa
+∞
97.2
84
*
EKA10
NOMESCO Finland
Biopsy of cheek
103.0
69.3
73
12
EKB00
NOMESCO Finland
Excision of lesion of cheek
499.5
68.6
64
*
8070/3-C06.0
ICD-O-3
Squamous cell carcinoma, NOS, of cheeck mucosa
+∞
64.7
58
*
130
Kela drug reimbursment
Malignant tumour
+∞
58.7
53
*
8070/3-C06.9
ICD-O-3
Squamous cell carcinoma, NOS, of mouth, NOS
+∞
55.2
50
*
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
+∞
45.9
42
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
10.9
44.7
113
250
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
188.4
42.9
43
*
ZZQ00
NOMESCO Finland
Free microvascular graft of skin
+∞
41.3
38
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
257.1
40.7
40
*
SAA03
NOMESCO Finland
Extended examination of mouth
9.3
40.2
123
354
C03.1
ICD-10 Finland
Malignant neoplasm: Lower gum
+∞
39.0
36
*
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
29.4
37.6
51
24
GBB00
NOMESCO Finland
Tracheostomy
124.5
37.5
39
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
10.6
34.6
76
118
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
+∞
34.5
32
*
EDB00
NOMESCO Finland
Partial excision of mandible
+∞
34.5
32
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
112.5
34.2
36
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
23.0
33.5
49
29
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
46.6
33.2
40
11
ECA20
NOMESCO Finland
Biopsy of gingiva
139.6
33.0
34
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
32.3
30
*
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
18.4
30.4
48
35
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
46.4
28.3
34
9
A07AA02
ATC
nystatin; oral
15.3
28.1
48
42
SBB10
NOMESCO Finland
Teeth copy
18.7
26.9
42
29
XX3DW
NOMESCO Finland
Time consuming IT work
20.4
26.5
40
25
WF002
NOMESCO Finland
Radical radiotherapy
+∞
25.6
24
*
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
16.4
25.6
42
33
K13.29
ICD-10 Finland
Indefinite leukoplakia
44.8
24.9
30
8
EBB10
NOMESCO Finland
Insertion of dental implant
39.8
24.3
30
9
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
31.0
23.6
31
12
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
92.2
22.3
24
*
A03FA01
ATC
metoclopramide; systemic, rectal
7.7
21.1
53
93
K13.78
ICD-10 Finland
Other change in the oral mucosa
37.8
20.9
26
8
EEB00
NOMESCO Finland
Partial excision of maxilla
+∞
20.2
19
*
C02.11
ICD-10 Finland
Malignant neoplasm of border of tongue
+∞
20.2
19
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
20.2
19
*
WX408
NOMESCO Finland
General anesthesy, balanced
5.1
19.6
77
235
H02AB02
ATC
dexamethasone; systemic
39.4
19.5
24
7
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.4
18.9
67
181
SBA00
NOMESCO Finland
Microbiological examinations
22.5
18.9
27
14
SAA04
NOMESCO Finland
Special inverstigation of mouth
10.8
18.3
36
41
ZZA00
NOMESCO Finland
Split skin graft
19.7
18.1
27
16
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
16.9
16
*
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
187.0
16.8
17
*
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
44.7
16.7
20
5
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
66.4
16.1
18
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
24.9
16.0
22
10
C03.0
ICD-10 Finland
Malignant neoplasm: Upper gum
+∞
15.9
15
*
EKW99
NOMESCO Finland
Other operation on cheek
+∞
15.9
15
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
15.9
15
*
WX110
NOMESCO Finland
Local anesthesy
4.1
15.8
135
786
EHA10
NOMESCO Finland
Biopsy of palate
87.6
14.8
16
*
A04AA02
ATC
granisetron; systemic, transdermal
87.6
14.8
16
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
14.8
14
*
SPD05
NOMESCO Finland
Demanding fitting of total teeth prosthesis
+∞
14.8
14
*
SXA10
NOMESCO Finland
Epithel biopsy of mouth
39.8
14.7
18
5
SPF30
NOMESCO Finland
Soling for prothesis
13.7
14.6
25
21
SPF00
NOMESCO Finland
Repatation of teeth prosthesis
10.9
14.6
28
30
WZB00
NOMESCO Finland
Telephone receipt or other advice
4.0
14.3
72
262
SPF20
NOMESCO Finland
Temporary soling for filling
33.1
14.2
18
6
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prothetic work
7.9
14.1
33
50
WX402
NOMESCO Finland
General anaesthesia
5.5
13.8
44
101
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
+∞
13.7
13
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
13.7
13
*
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
+∞
13.7
13
*
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
8.6
13.7
30
41
K13.20
ICD-10 Finland
Idiopathic leukoplakia
151.2
13.6
14
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
3.5
13.5
94
439
EBB15
NOMESCO Finland
Insertion of dental implant abutment
43.7
13.4
16
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
9.8
13.4
27
32
K13.74
ICD-10 Finland
Lichen rubs planus in the mouth
26.7
12.7
17
7
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
12.6
12
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
12.6
12
*
ZZQ20
NOMESCO Finland
Free microvascular graft of skin, muscle and bone
+∞
12.6
12
*
D10.30
ICD-10 Finland
Benign tumor of the mucous membrane of the cheek
+∞
12.6
12
*
C05.0
ICD-10 Finland
Malignant neoplasm: Hard palate
+∞
12.6
12
*
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
+∞
12.6
12
*
EBA15
NOMESCO Finland
Extraction of large number of teeth
9.1
12.4
26
33
Z51.5
ICD-10 Finland
Palliative care
12.4
11.9
21
19
A04AA01
ATC
ondansetron; systemic, rectal
20.7
11.8
17
9
C06.21
ICD-10 Finland
Malignant tumor of the lower retromolar surface
+∞
11.6
11
*
C06.13
ICD-10 Finland
Malignant tumor of the lower cheek
+∞
11.6
11
*
C06.9
ICD-10 Finland
Malignant neoplasm: Mouth, unspecified
+∞
11.6
11
*
L03AA02
ATC
filgrastim; parenteral
+∞
11.6
11
*
EHB00
NOMESCO Finland
Excision of lesion of palate
+∞
11.6
11
*
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
128.0
11.6
12
*
EJB10
NOMESCO Finland
Excision of lesion of apex or body of tongue
37.8
11.4
14
*
N02AA05
ATC
oxycodone; systemic
4.5
11.4
43
117
R4190
NOMESCO Finland
Nutritional therapy
14.2
10.9
18
14
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
64.0
10.8
12
*
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
116.7
10.5
11
*
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
6.3
10.5
28
51
EJB30
NOMESCO Finland
Excision of lesion of floor of mouth
+∞
10.5
10
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
10.5
10
*
WX707
NOMESCO Finland
Fiberoscopic intubation
+∞
10.5
10
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
14.3
10.4
17
13
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.9
10.2
98
536
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
10.5
10.1
19
20
SXC03
NOMESCO Finland
Other oral or dental procedure
18.9
9.6
14
8
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
+∞
9.5
9
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
9.5
9
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
9.5
9
*
C06.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of other and unspecified parts of mouth
+∞
9.5
9
*
C05.1
ICD-10 Finland
Malignant neoplasm: Soft palate
+∞
9.5
9
*
D10.39
ICD-10 Finland
Benign tumor in other or unspecified part of oral cavity UNS
+∞
9.5
9
*
8070/3-C06.2
ICD-O-3
Squamous cell carcinoma, NOS, of retromolar area
+∞
9.5
9
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
9.5
9
*
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
14.8
9.4
15
11
ZXD10
NOMESCO Finland
Scheduled procedure
2.8
9.3
81
412
ZXE40
NOMESCO Finland
More than seven and less than nine hours
10.9
9.3
17
17
K05.30
ICD-10 Finland
Periodontitis complex
4.3
9.1
35
97
TPH07
NOMESCO Finland
Cathetrisation of artery
4.4
9.0
33
87
EBA10
NOMESCO Finland
Surgical removal of tooth
4.5
9.0
32
82
WX872
NOMESCO Finland
Intensive care
5.4
8.7
26
55
K13.28
ICD-10 Finland
Other leukoplakia or disorder of epithelium of the palate or tongue
94.4
8.5
9
*
SPD10
NOMESCO Finland
Fitting and preparation of partial total prothesis of teeth attached with implants
94.4
8.5
9
*
JCW98
NOMESCO Finland
Other transluminal endoscopic procedure on oesophagus
94.4
8.5
9
*
SAA02
NOMESCO Finland
Basic examination of mouth
2.6
8.4
114
732
C02.10
ICD-10 Finland
Malignant neoplasm of tip of tongue
+∞
8.4
8
*
EKB10
NOMESCO Finland
Excision of extensive neoplasm or lesion in cheek
+∞
8.4
8
*
EKC20
NOMESCO Finland
Plastic repair of cheek
+∞
8.4
8
*
C04.0
ICD-10 Finland
Malignant neoplasm: Anterior floor of mouth
+∞
8.4
8
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
8.4
8
*
115
Kela drug reimbursment
Breast cancer
+∞
8.4
8
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
8.8
8.3
17
21
SPA20
NOMESCO Finland
Selection and insertion of implantdistans
35.1
8.2
10
*
SPA10
NOMESCO Finland
Setting attachments on tooth or implanted bracket or imblant based structures
35.1
8.2
10
*
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
9.1
8.0
16
19
R4110
NOMESCO Finland
Physiotherapy
2.9
8.0
58
257
EBA00
NOMESCO Finland
Extraction of tooth
2.7
7.9
69
344
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
8.1
7.9
17
23
L43.8
ICD-10 Finland
Other lichen planus
16.0
7.8
12
8
EB1AD
NOMESCO Finland
Cone beam CT of teeth and jaws (one quarter)
47.1
7.8
9
*
TEA00
NOMESCO Finland
Biopsy of lip
26.3
7.7
10
*
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
26.3
7.7
10
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.8
7.6
33
101
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
7.4
7.5
17
25
K08.2
ICD-10 Finland
Atrophy of edentulous alveolar ridge
9.0
7.5
15
18
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
83.4
7.5
8
*
K05.31
ICD-10 Finland
Periodontitis pronounced
3.9
7.4
31
92
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
7.3
7
*
ZX095
NOMESCO Finland
Combined chemoradiotherapy
+∞
7.3
7
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
+∞
7.3
7
*
EDB20
NOMESCO Finland
Hemimandibulectomy
+∞
7.3
7
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
7.3
7
*
YA1CD
NOMESCO Finland
Very extensive CT examination of head and neck for dose design of radiotherapy
+∞
7.3
7
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
7.3
7
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
7.3
7
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
+∞
7.3
7
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
7.3
7
*
A04AD12
ATC
aprepitant; systemic
+∞
7.3
7
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.5
7.3
71
371
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
6.1
7.3
19
34
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
21.1
7.2
10
5
EAA10
NOMESCO Finland
Excision of lesion of lip
21.1
7.2
10
5
L43.9
ICD-10 Finland
Lichen planus, unspecified
10.7
7.2
13
13
WZC30
NOMESCO Finland
Teaching
4.2
7.1
26
69
SPE90
NOMESCO Finland
Other fitting and preparation of partial tooth prosthesis
7.2
7.0
16
24
ZXE00
NOMESCO Finland
One hour or less
2.4
7.0
77
427
UDQ12
NOMESCO Finland
Flexible laryngoscopy
6.0
6.8
18
33
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
41.7
6.8
8
*
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
41.7
6.8
8
*
ZXE60
NOMESCO Finland
More than 12 and less than 15 hours
23.6
6.7
9
*
A01AB04
ATC
amphotericin B; local oral
4.5
6.7
23
57
SAA01
NOMESCO Finland
Simple examination of mouth
2.3
6.7
116
800
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
72.3
6.5
7
*
B37.03
ICD-10 Finland
Chronic atrophic candida infection in the mouth
72.3
6.5
7
*
R02AD02
ATC
lidocaine; local oral
18.9
6.3
9
5
ECB20
NOMESCO Finland
Oral alveoplasty
18.9
6.3
9
5
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
6.2
6.3
16
28
EB1WA
NOMESCO Finland
NA
+∞
6.3
6
*
XF612
NOMESCO Finland
Measurement of central venous pressure
+∞
6.3
6
*
C04.9
ICD-10 Finland
Malignant neoplasm: Floor of mouth, unspecified
+∞
6.3
6
*
C03.9
ICD-10 Finland
Malignant neoplasm: Gum, unspecified
+∞
6.3
6
*
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
+∞
6.3
6
*
Z51.0
ICD-10 Finland
Radiotherapy session
+∞
6.3
6
*
PJD91
NOMESCO Finland
Excision of lymph nodes in neck, 1 to 2 areas in total
+∞
6.3
6
*
9680/3-C06.9
ICD-O-3
Diffuse large B-cell lymphoma, NOS, of mouth, NOS
+∞
6.3
6
*
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
27.8
6.3
8
*
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
7.7
6.0
13
18

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_MOUTHNAS_EXALLC – Malignant neoplasm of other and unspecified parts of mouth, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).