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Malignant neoplasm of other and unspecified major salivary glands, excluding all cancers (controls excluding all cancers)

C3_SALIVARYNAS_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C08
  • Hospital discharge: ICD-9 142
  • Hospital discharge: ICD-8 142
  • Cause of death: ICD-10 C08
  • Cause of death: ICD-9 142
  • Cause of death: ICD-8 142
  • Cause of death: excluded ICD-9 1420
  • Cancer registry: Topography ICD-O-3 C08
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

265

4. Check minimum number of events

None

265

5. Include endpoints

None

265

6. Filter based on genotype QC (FinnGen only)

265

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of other and unspecified major salivary glands, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 265 124 141
Unadjusted period prevalence (%) 0.05 0.04 0.06
Median age at first event (years) 61.79 57.64 65.45

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
101
Matched controls
1011
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
ELB30
NOMESCO Finland
Excision of submandibular gland
691.1
44.9
41
*
C08.09
ICD-10 Finland
Malignant tumor of the submandibular or submaxillary gland, other or unspecified histology
+∞
34.3
31
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
33.1
30
*
D11.70
ICD-10 Finland
Gland sublingual
+∞
33.1
30
*
130
Kela drug reimbursment
Malignant tumour
+∞
33.1
30
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
10.9
26.5
69
166
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
+∞
25.0
23
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
32.7
24.5
32
14
C08.02
ICD-10 Finland
Cystic adenocarcinoma of the submandibular or submaxillary glands
+∞
21.6
20
*
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
+∞
21.6
20
*
XX3DW
NOMESCO Finland
Time consuming IT work
17.5
20.5
33
27
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
19.7
19.7
30
21
8200/3-C08.0
ICD-O-3
Adenoid cystic carcinoma of submandibular gland
+∞
19.4
18
*
H02AB02
ATC
dexamethasone; systemic
201.8
17.0
17
*
C08.00
ICD-10 Finland
Malignant tumor of submandibular or submaxillary gland, not histology
+∞
16.0
15
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
32.9
14.9
19
7
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
62.6
14.3
16
*
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
40.3
14.0
17
5
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
13.9
13
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
13.9
13
*
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
+∞
13.9
13
*
A04AA02
ATC
granisetron; systemic, transdermal
160.6
13.8
14
*
D11.0
ICD-10 Finland
Benign neoplasm: Parotid gland
23.9
13.0
18
9
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
12.8
12
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
12.8
12
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
12.8
12
*
WF002
NOMESCO Finland
Radical radiotherapy
+∞
12.8
12
*
Z51.5
ICD-10 Finland
Palliative care
19.1
12.7
19
12
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
73.7
11.9
13
*
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
134.6
11.7
12
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
11.7
11
*
D37.00
ICD-10 Finland
Aryepiglottic fold marginal zone
40.1
11.6
14
*
C08.90
ICD-10 Finland
Malignant tumor in unspecified large salivary gland without histology
+∞
10.6
10
*
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
+∞
10.6
10
*
N02AA05
ATC
oxycodone; systemic
5.8
10.5
32
74
A07AA02
ATC
nystatin; oral
10.9
10.1
19
21
SAA03
NOMESCO Finland
Extended examination of mouth
4.0
9.9
57
247
A03FA01
ATC
metoclopramide; systemic, rectal
6.6
9.8
26
50
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
+∞
9.5
9
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
9.5
9
*
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
+∞
9.5
9
*
C08.0
ICD-10 Finland
Malignant neoplasm: Submandibular gland
+∞
9.5
9
*
C08.01
ICD-10 Finland
Diverse adenocarcinoma of the mandibular salivary gland
+∞
9.5
9
*
WX408
NOMESCO Finland
General anesthesy, balanced
4.4
9.2
38
121
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
26.9
9.1
12
5
XW000
NOMESCO Finland
Bone marrow biopsy
16.3
8.5
13
9
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
3.5
8.4
57
270
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
8.4
8
*
9699/3-C08.0
ICD-O-3
Marginal zone B-cell lymphoma, NOS, of submandibular gland
+∞
8.4
8
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
+∞
8.4
8
*
JN4BD
NOMESCO Finland
Extensive body CT
9.0
8.3
17
22
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
9.8
8.2
16
19
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
5.6
8.1
24
53
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
48.9
7.8
9
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
48.9
7.8
9
*
C08.94
ICD-10 Finland
Mucoepidermoid carcinoma of an unspecified large salivary gland
+∞
7.4
7
*
8430/3-C08.0
ICD-O-3
Mucoepidermoid carcinoma of submandibular gland
+∞
7.4
7
*
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
+∞
7.4
7
*
8200/3-C08.9
ICD-O-3
Adenoid cystic carcinoma of major salivary gland, NOS
+∞
7.4
7
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
7.4
7
*
L02BB03
ATC
bicalutamide; oral
+∞
7.4
7
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
7.4
7
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
+∞
7.4
7
*
Z51.0
ICD-10 Finland
Radiotherapy session
+∞
7.4
7
*
WZC30
NOMESCO Finland
Teaching
4.7
6.5
22
56
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
74.3
6.5
7
*
L03AA02
ATC
filgrastim; parenteral
74.3
6.5
7
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
28.6
6.3
8
*
JN6AD
NOMESCO Finland
CT of torso and neck
28.6
6.3
8
*
EJB30
NOMESCO Finland
Excision of lesion of floor of mouth
+∞
6.3
6
*
A04AD12
ATC
aprepitant; systemic
+∞
6.3
6
*
C08.91
ICD-10 Finland
Adenocarcinoma of mixed cell type in unspecified large salivary gland
+∞
6.3
6
*
YA1CD
NOMESCO Finland
Very extensive CT examination of head and neck for dose design of radiotherapy
+∞
6.3
6
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
6.3
6
*
EHB00
NOMESCO Finland
Excision of lesion of palate
+∞
6.3
6
*
C08.9
ICD-10 Finland
Malignant neoplasm: Major salivary gland, unspecified
+∞
6.3
6
*
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
+∞
6.3
6
*
B01AB10
ATC
tinzaparin; parenteral
8.9
6.0
12
15
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
16.3
6.0
9
6

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_SALIVARYNAS_EXALLC – Malignant neoplasm of other and unspecified major salivary glands, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).