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Neuroendocrine tumor and carcinoma of small intestine

C3_SMALL_INTESTINE_NEUROENDOCRINE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 C17
  • Cancer registry: Morphology ICD-O-3 8240|824[2-4]|8246|8249
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

450

4. Check minimum number of events

None

450

5. Include endpoints

None

450

6. Filter based on genotype QC (FinnGen only)

450

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF8

Similar endpoints

List of similar endpoints to Neuroendocrine tumor and carcinoma of small intestine based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 450 217 233
Unadjusted period prevalence (%) 0.09 0.07 0.10
Median age at first event (years) 63.05 61.11 64.85

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
419
Matched controls
4188
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C17.9
ICD-10 Finland
Malignant neoplasm: Small intestine, unspecified
2056.9
295.5
252
*
JFB00
NOMESCO Finland
Partial resection of small intestine
132.5
189.6
194
27
130
Kela drug reimbursment
Malignant tumour
26.5
162.0
248
217
8240/3-C17.9
ICD-O-3
Neuroendocrine tumor, NOS, of small intestine, NOS
+∞
153.9
138
*
D37.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Small intestine
422.9
148.9
141
5
H01CB03
ATC
lanreotide; parenteral
953.1
142.8
132
*
C17.2
ICD-10 Finland
Malignant neoplasm: Ileum
630.6
141.2
132
*
E34.0
ICD-10 Finland
Carcinoid syndrome
1711.0
132.8
122
*
H01CB02
ATC
octreotide; parenteral
851.0
131.0
122
*
8240/3-C17.2
ICD-O-3
Neuroendocrine tumor, NOS, of ileum
+∞
117.3
107
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
14.2
69.6
126
123
XX7JT
NOMESCO Finland
Somatostatin isotope ablative therapy
763.8
68.0
65
*
JN7AQ
NOMESCO Finland
Somatostatin receptor SPET med low dose CT
264.8
67.3
67
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
26.0
66.5
94
46
JN5ER
NOMESCO Finland
PET-CT of receptors in whole body
127.8
61.8
65
6
JN3BD
NOMESCO Finland
Extensive abdominal CT
7.9
61.0
161
305
JN4BD
NOMESCO Finland
Extensive body CT
7.7
60.3
163
319
8249/3-C17.9
ICD-O-3
Neuroendocrine tumor, grade 2 of small intestine, NOS
+∞
52.2
49
*
D77
ICPC
Malignant digestive neopl other/NOS
103.0
50.2
54
6
8249/3-C17.2
ICD-O-3
Neuroendocrine tumor, grade 2 of ileum
+∞
50.0
47
*
WD225
NOMESCO Finland
Demanding therapy of methastized malignancy with hormones
50.5
47.7
57
13
XX9AN
NOMESCO Finland
Complementary isotope examination or additional picture
180.1
46.9
48
*
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
13.2
46.6
85
79
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
14.5
46.5
81
68
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
37.0
43.2
55
17
C17.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of small intestine
232.6
41.7
42
*
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
13.6
40.9
73
64
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
4.1
40.3
234
983
B01AB05
ATC
enoxaparin; parenteral
4.0
39.0
227
948
JN4CD
NOMESCO Finland
Very extensive body CT
10.6
38.9
79
90
JN4AD
NOMESCO Finland
Body CT examination
6.5
36.0
102
196
JFB30
NOMESCO Finland
Right hemicolectomy
18.3
35.8
56
35
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
6.6
34.0
95
178
302
Kela drug reimbursment
Interferon alfa
+∞
32.7
31
*
UJF32
NOMESCO Finland
Coloscopy
3.6
31.2
190
780
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.5
30.5
199
859
T73
ICPC
Neoplasm endocrine other/unspecified
+∞
29.5
28
*
JAH00
NOMESCO Finland
Laparotomy
13.3
29.4
52
44
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
15.8
29.2
48
34
C10AC01
ATC
colestyramine; oral
12.2
28.7
53
49
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
11.5
28.4
54
53
WX408
NOMESCO Finland
General anesthesy, balanced
3.4
28.3
182
764
JFB20
NOMESCO Finland
Ileocaecal resection
83.6
28.2
31
*
C17.1
ICD-10 Finland
Malignant neoplasm: Jejunum
300.4
28.1
28
*
JFB31
NOMESCO Finland
Laparoscopic right hemicolectomy
20.5
27.6
41
22
JKA20
NOMESCO Finland
Cholecystectomy
10.5
26.6
53
57
TPH07
NOMESCO Finland
Cathetrisation of artery
4.7
26.6
101
266
D13.3
ICD-10 Finland
Benign neoplasm: Other and unspecified parts of small intestine
37.0
24.6
31
9
L03AB05
ATC
interferon alfa-2b; parenteral
59.8
24.3
28
5
8246/3-C17.9
ICD-O-3
Neuroendocrine carcinoma, NOS, of small intestine, NOS
+∞
23.1
22
*
C17.0
ICD-10 Finland
Malignant neoplasm: Duodenum
242.6
22.8
23
*
JN7AN
NOMESCO Finland
Somatostatin receptor isotope imaging
+∞
22.1
21
*
JN7SN
NOMESCO Finland
Somatostatin receptor SPECT
+∞
22.1
21
*
JN3AD
NOMESCO Finland
Abdominal CT examination
4.9
21.7
76
181
8240/3-C17.0
ICD-O-3
Neuroendocrine tumor, NOS, of duodenum
+∞
21.0
20
*
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
18.1
20.8
32
19
UJF30
NOMESCO Finland
Ileoscopy through colon
4.2
20.1
82
227
A09AA02
ATC
multienzymes (lipase, protease etc.)
11.8
20.1
37
34
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
14.4
18.5
31
23
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
5.5
18.1
55
111
JAH01
NOMESCO Finland
Laparoscopy
7.8
18.1
42
59
L01AX03
ATC
temozolomide; systemic
21.2
18.0
26
13
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
13.4
17.4
30
24
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
8.4
17.2
38
49
JF1BD
NOMESCO Finland
Very extensive small bowel CT
52.3
17.1
20
*
A03FA01
ATC
metoclopramide; systemic, rectal
2.8
16.9
130
573
UJF92
NOMESCO Finland
Capsular endoscopy
10.7
16.7
32
32
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
6.3
16.4
44
76
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.3
15.9
89
318
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.4
15.7
178
973
8246/3-C17.2
ICD-O-3
Neuroendocrine carcinoma, NOS, of ileum
+∞
15.7
15
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
15.7
131
607
C77.2
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Intra-abdominal lymph nodes
39.7
15.5
19
5
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.4
15.5
47
95
ZXE10
NOMESCO Finland
More than one and less than three hours
2.4
15.4
192
1100
JN3CG
NOMESCO Finland
Extensive MRI examination of abdomen with high intensity magnet
29.9
15.3
20
7
A79
ICPC
Malignancy NOS
11.0
14.9
28
27
B01AB10
ATC
tinzaparin; parenteral
3.9
14.3
61
174
K56.7
ICD-10 Finland
Ileus, unspecified
11.5
14.2
26
24
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
11.5
13.7
25
23
R4190
NOMESCO Finland
Nutritional therapy
6.5
13.5
35
58
XX9AD
NOMESCO Finland
Complementary CT
+∞
12.6
12
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.0
12.0
49
135
JN3DG
NOMESCO Finland
Very extensive MRI examination with high intensity magnet
48.1
11.9
14
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.4
11.9
59
191
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.1
11.7
209
1356
ZXE20
NOMESCO Finland
More than three and less than five hours
2.6
11.4
90
394
Z51.88
ICD-10 Finland
Other specified medical care
8.0
11.3
25
33
JN4DD
NOMESCO Finland
Scout CT scan of torso
28.9
10.8
14
5
JFA73
NOMESCO Finland
Excision of lesion of small intestine
112.7
10.5
11
*
Z51.5
ICD-10 Finland
Palliative care
3.4
10.3
50
159
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
24.1
10.3
14
6
ZX114
NOMESCO Finland
Intramuscular
11.7
10.1
18
16
A02BC02
ATC
pantoprazole; systemic
2.0
10.0
293
2245
WX402
NOMESCO Finland
General anaesthesia
2.5
10.0
87
398
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
9.4
9.6
19
21
N02AA05
ATC
oxycodone; systemic
2.4
9.5
91
440
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
9.1
213
1482
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.1
8.9
49
169
ZXD05
NOMESCO Finland
Urgent procedure
2.0
8.7
145
887
JFB21
NOMESCO Finland
Laparoscopic ileocaecal resection
51.1
8.7
10
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.4
8.6
77
358
K56.0
ICD-10 Finland
Paralytic ileus
11.9
8.6
15
13
C78.8
ICD-10 Finland
Secondary malignant neoplasm of other and unspecified digestive organs
28.1
8.5
11
*
R10.0
ICD-10 Finland
Acute abdomen
5.2
8.5
25
50
JN5SR
NOMESCO Finland
Very extensive PET-CT of receptors in upper body
+∞
8.4
8
*
8240/3-C17.1
ICD-O-3
Neuroendocrine tumor, NOS, of jejunum
+∞
8.4
8
*
1522B
ICD-9 Finland
Malignant neoplasm of small intestine, including duodenum, Ileum[NEOPLASMA MALIGNUM ILEI,ALIA DEFINITA SEU NUD]
+∞
8.4
8
*
N02BE01
ATC
paracetamol; systemic, rectal
2.4
8.2
372
3229
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.2
8.1
93
487
D37.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Digestive organ, unspecified
17.6
8.1
12
7
JFB33
NOMESCO Finland
Other resection comprising small intestine and colon
34.0
8.1
10
*
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
3.5
7.9
36
110
ZXK00
NOMESCO Finland
Conversion from percutaneous endoscopic to open procedure
15.4
7.8
12
8
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
8.3
7.7
16
20
D75
ICPC
Malignant neoplasm colon/rectum
12.1
7.6
13
11
D64.9
ICD-10 Finland
Anaemia, unspecified
2.5
7.5
58
250
C17
ICD-10 Finland
Malignant neoplasm of small intestine
81.4
7.4
8
*
K50.9
ICD-10 Finland
Crohn disease, unspecified
11.1
7.3
13
12
C17.3
ICD-10 Finland
Malignant neoplasm: Meckel diverticulum
+∞
7.3
7
*
E340, C179
ICD-10 Finland
NA
+∞
7.3
7
*
C18.09
ICD-10 Finland
Malignant tumor of caecum other or unspecified histology
16.1
7.3
11
7
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.1
7.2
94
517
6402
FHL
Small bowel resection
30.6
7.2
9
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.7
7.2
30
86
L01BC06
ATC
capecitabine; oral
3.7
7.2
30
86
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.2
7.1
78
397
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
7.7
7.0
15
20
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.5
6.8
51
217
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
3.4
6.8
31
96
C26.0
ICD-10 Finland
Malignant neoplasm: Intestinal tract, part unspecified
22.9
6.7
9
*
D99
ICPC
Disease digestive system other
12.5
6.6
11
9
C26.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of digestive system
70.9
6.4
7
*
C18.99
ICD-10 Finland
Malignant tumor in unspecified location in the colon other or unspecified histology
14.6
6.4
10
7
ZXE60
NOMESCO Finland
More than 12 and less than 15 hours
14.6
6.4
10
7
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.3
6.4
61
294
B03BA03
ATC
hydroxocobalamin; parenteral
3.0
6.4
36
128
A04AA02
ATC
granisetron; systemic, transdermal
3.0
6.3
36
129
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
7.2
6.3
14
20
JJA20
NOMESCO Finland
Open biopsy of liver
27.1
6.2
8
*
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
3.1
6.2
32
109
ZX112
NOMESCO Finland
Subcutaneous
4.7
6.0
19
42

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_SMALL_INTESTINE_NEUROENDOCRINE – Neuroendocrine tumor and carcinoma of small intestine

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).