No definition available.
Hereditary deficiency of other clotting factors
DOID EFO Endpoint Browser PheWeb
D3_HEREDOTHCLOFACTORS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
346 |
4. Check minimum number of eventsNone |
346 |
5. Include endpointsNone |
346 |
6. Filter based on genotype QC (FinnGen only) |
330 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D68
- Name in latin
- Deficientia hereditaria aliorum factorum coagulationis
Similar endpoints
↥List of similar endpoints to
Hereditary deficiency of other clotting factors
based on the number of shared cases.
Similar with more cases:
- Other coagulation defects
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2150 | 1552 | 590 |
| Only index persons | 2039 | 1500 | 539 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.02 |
| Only index persons | 0.05 | 0.06 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 36.75 | 32.72 | 47.34 |
| Only index persons | 36.81 | 32.79 | 47.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 330 | 235 | 95 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.04 |
| Median age at first event (years) | 42.63 | 36.65 | 57.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 346
- Matched controls
- 3460
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D68.2
ICD-10 Finland
Hereditary deficiency of other clotting factors
+∞
307.7
342
*
D68.8
ICD-10 Finland
Other specified coagulation defects
703.4
144.7
133
*
B01AA03
ATC
warfarin; systemic
11.4
106.5
146
208
B01AB05
ATC
enoxaparin; parenteral
8.3
87.0
220
601
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
17.9
76.2
66
45
B01AB04
ATC
dalteparin; parenteral
14.2
75.0
75
66
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
22.0
53.7
41
21
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
87.8
42.0
46
6
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
5.8
38.0
81
172
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
9.4
37.8
48
58
I80.29
ICD-10 Finland
Phlebitis and thrombophlebitis of other deep vessels of lower extremities
11.4
33.9
37
36
D68.9
ICD-10 Finland
Coagulation defect, unspecified
268.6
25.0
25
*
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
3.7
20.0
76
247
D68.0
ICD-10 Finland
Von Willebrand disease
+∞
16.8
16
*
I82.88
ICD-10 Finland
Embolism and thrombosis of other specified veins
16.3
14.6
23
15
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
37.8
14.6
18
5
I82.9
ICD-10 Finland
Embolism and thrombosis of unspecified vein
15.3
14.3
23
16
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.3
14.1
39
100
N02AX02
ATC
tramadol; systemic, rectal
2.4
14.1
164
946
O28.0
ICD-10 Finland
Abnormal haematological finding on antenatal screening of mother
72.6
12.7
14
*
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
5.2
12.4
26
53
K94
ICPC
Phlebitis/thrombophlebitis
14.1
12.1
20
15
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.2
11.8
155
923
B01AB10
ATC
tinzaparin; parenteral
3.3
11.7
47
156
I80.9
ICD-10 Finland
Phlebitis and thrombophlebitis of unspecified site
18.6
10.8
16
9
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
10.7
103
536
A46
ICD-10 Finland
Erysipelas
2.9
10.3
54
209
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.1
10.0
45
160
R60.0
ICD-10 Finland
Localized oedema
3.0
9.6
46
169
I87.0
ICD-10 Finland
Postthrombotic syndrome
31.0
9.5
12
*
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
2.9
9.4
46
171
D68.4
ICD-10 Finland
Acquired coagulation factor deficiency
+∞
9.4
9
*
R06.0
ICD-10 Finland
Dyspnoea
2.2
9.3
98
525
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.8
9.3
51
202
M79.6
ICD-10 Finland
Pain in limb
2.0
9.1
161
1047
I80.1
ICD-10 Finland
Phlebitis and thrombophlebitis of femoral vein
16.8
8.6
13
8
4511A
ICD-9 Finland
Phlebitis and thrombophlebitis, Of deep vessels of lower extremities
20.6
8.5
12
6
R42
ICD-10 Finland
Dizziness and giddiness
2.3
8.4
77
388
126
Kela drug reimbursment
Chronic coagulation defects
+∞
8.4
8
*
R07.4
ICD-10 Finland
Chest pain, unspecified
2.1
8.3
97
539
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
4.6
8.3
20
46
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
8.2
61
281
I80.20
ICD-10 Finland
Phlebitis and thrombophlebitis in the iliac vein
22.6
8.1
11
5
K99
ICPC
Cardiovascular disease other
9.7
7.9
15
16
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.2
7.4
70
356
B01AF01
ATC
rivaroxaban; oral
2.7
7.3
42
170
I80.8
ICD-10 Finland
Phlebitis and thrombophlebitis of other sites
8.2
7.2
15
19
N03AX16
ATC
[U] pregabalin
2.1
7.1
80
436
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
7.2
7.1
16
23
N02AJ06
ATC
codeine and paracetamol; systemic
1.8
6.9
156
1071
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
6.9
77
418
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.8
6.9
21
58
E0000UV, ,
ATC
1.8
6.8
150
1022
45100
ICD-8 Finland
Phlebitis and thrombophlebitis, Of lower extremities
40.9
6.8
8
*
AA1AD
NOMESCO Finland
CT of head and brain
2.0
6.7
82
459
XF400
NOMESCO Finland
ECG with 12 standard connections
2.3
6.5
52
246
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.1
6.5
28
97
H02AB06
ATC
prednisolone; systemic
1.8
6.4
162
1143
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
6.3
93
556
D68
ICD-10 Finland
Other coagulation defects
+∞
6.3
6
*
NA1AD
NOMESCO Finland
Cervical spine CT examination
3.4
6.1
22
68
A02BC02
ATC
pantoprazole; systemic
1.8
6.1
220
1713
R4110
NOMESCO Finland
Physiotherapy
1.9
6.0
98
604
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
122
326
5.24
44.62
5.5
2.1
34.36
29.86
s
1.67
116
321
220
1026
4.14
36.58
39.6
10.6
1.60
1.14
inr
6.47
70
329
162
617
4.06
36.08
4.3
1.8
0.89
0.88
mg/l
0.02
116
472
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
46
56
9.32
35.94
6.4
3.5
0.35
0.35
u/ml
0.00
25
34
33
48
7.49
22.04
1.1
1.1
—
—
—
0
0
28
44
6.84
17.37
1.4
1.3
1.78
6.13
u/ml
—
9
15
27
47
6.15
15.17
1.4
1.2
3.08
5.16
u/ml
0.46
13
19
180
1068
2.43
14.67
12.6
6.5
1.21
1.22
mmol/l
0.61
170
986
89
392
2.71
13.52
4.0
2.4
13.47
13.81
umol/l
0.20
84
364
192
1206
2.33
13.31
9.3
7.0
1.21
1.22
mmol/l
0.40
166
1045
78
329
2.77
12.83
4.4
2.4
23.53
23.41
%
0.03
69
288
172
1051
2.27
12.49
7.2
4.6
36.49
36.37
g/l
0.11
160
993
207
1385
2.23
11.78
7.2
5.4
28.39
28.91
%
0.31
196
1308
204
1368
2.20
11.40
7.0
5.3
57.13
56.98
%
0.07
194
1286
271
2092
2.36
10.01
8.7
6.6
73.52
76.38
u/l
0.47
257
1964
116
656
2.16
9.68
3.2
2.0
2.62
2.82
mg/l
0.62
96
570
211
1496
2.05
9.45
8.1
4.6
6.40
6.46
mmol/l
0.11
204
1379
51
207
2.72
8.88
2.8
2.6
78.37
70.61
ml/min/173m2
0.86
32
82
224
1659
1.99
8.44
9.0
8.5
4.09
4.05
e9/l
0.08
206
1454
83
434
2.20
8.29
3.9
3.3
289.64
168.93
ng/l
0.34
61
286
53
229
2.55
8.13
3.6
4.1
218.19
232.10
u/l
0.63
48
223
191
1358
1.91
7.93
6.5
5.7
9.92
10.82
umol/l
0.78
183
1298
20
34
6.18
7.81
2.8
2.1
—
—
—
0
0
108
637
2.01
7.80
3.3
2.0
—
—
—
0
0
145
964
1.87
7.23
3.9
3.2
26.09
30.53
u/l
2.15
138
930
56
270
2.28
6.73
15.0
6.6
105.37
104.53
mmol/l
1.08
56
270
78
432
2.04
6.59
3.8
2.6
2.39
2.44
mmol/l
3.80
71
377
6
0
+∞
6.27
1.0
0.0
—
—
—
0
0
94
582
1.84
5.64
2.8
3.2
1332.24
1080.67
ng/l
0.28
68
483
129
879
1.75
5.61
3.6
3.0
2.32
2.35
mmol/l
2.99
112
791
177
1319
1.70
5.53
3.4
2.4
—
—
—
0
0
188
1426
1.70
5.48
4.4
2.8
92.41
88.78
ug/l
0.15
175
1341
27
101
2.81
5.48
1.6
1.9
—
—
—
0
0
88
547
1.82
5.17
1.3
1.2
29.82
28.86
iu/ml
0.03
26
185
317
2840
2.39
5.01
22.0
12.3
139.67
139.64
mmol/l
0.09
311
2762
127
885
1.69
4.97
3.4
3.3
18.95
29.24
ng/l
1.61
69
504
253
2112
1.74
4.88
5.4
3.7
10.94
10.15
mm/h
0.45
241
1969
317
2851
2.33
4.77
21.6
12.4
3.94
3.94
mmol/l
0.03
311
2765
65
383
1.86
4.50
3.3
2.5
4.20
2.56
e6/l
0.65
35
207
21
78
2.80
4.33
3.1
2.1
—
—
—
0
0
10
16
6.40
4.32
1.2
1.3
—
—
—
0
0
17
56
3.14
4.30
1.4
1.2
—
—
—
0
0
131
960
1.59
4.03
2.3
1.8
97.46
96.71
pmol/l
0.06
85
514
45
245
1.96
3.94
1.8
1.7
—
—
—
0
0
150
1141
1.56
3.89
3.1
2.4
74.12
74.06
nmol/l
0.01
140
1042
38
196
2.05
3.86
2.1
2.1
1421.07
3878.17
u/l
0.86
16
78
12
28
4.40
3.85
1.1
1.1
—
—
—
0
0
27
121
2.34
3.85
1.8
1.5
—
—
—
0
0
100
694
1.62
3.82
3.9
2.6
0.29
0.30
e6/l
0.07
80
509
12
29
4.25
3.74
1.1
1.1
—
—
—
0
0
12
29
4.25
3.74
1.1
1.1
—
—
—
0
0
12
29
4.25
3.74
1.1
1.1
—
—
—
0
0
84
561
1.66
3.73
1.7
1.5
20.79
22.34
nmol/l
0.38
72
488
113
814
1.58
3.68
2.3
2.5
53.43
61.19
u/l
0.67
106
767
43
236
1.94
3.68
3.6
3.0
—
—
—
0
0
80
530
1.66
3.66
1.3
1.2
23.05
7.53
u/ml
0.60
28
220
15
51
3.03
3.62
1.5
1.3
294.70
155.99
u/ml
—
10
30
44
246
1.90
3.57
1.9
1.7
—
—
—
0
0
61
378
1.75
3.56
1.9
1.7
—
—
—
0
0
295
2648
1.77
3.55
17.5
10.1
87.37
88.13
ml/min/173m2
0.23
260
2138
317
2913
2.05
3.49
19.6
11.3
18.53
20.33
mg/l
0.54
260
2238
122
904
1.54
3.48
4.2
2.8
—
—
—
0
0
41
226
1.92
3.47
18.9
10.1
1.17
1.38
mmol/l
0.15
34
176
11
28
4.02
3.31
1.1
1.1
—
—
—
0
0
98
699
1.56
3.28
1.7
1.7
1.44
1.38
mmol/l
0.28
84
602
63
404
1.68
3.24
3.2
2.4
0.73
0.93
e6/l
0.51
33
228
62
397
1.68
3.21
1.7
1.6
1221.28
1189.25
nmol/l
0.08
47
302
13
41
3.25
3.09
6.0
2.4
16.91
15.82
%
—
8
21
10
26
3.93
3.00
1.0
1.2
—
—
—
0
0
17
70
2.50
2.92
1.7
1.4
338.35
322.71
ug/g
0.09
11
41
5
6
8.43
2.76
2.8
2.2
—
—
—
0
0
324
3041
2.03
2.71
13.2
8.9
24.47
25.61
u/l
0.87
316
2951
15
61
2.53
2.65
1.9
2.7
—
—
—
0
0
10
30
3.40
2.62
1.3
1.1
—
—
—
0
0
19
88
2.23
2.56
1.8
1.8
2.98
5.72
iu/l
—
8
29
167
1378
1.41
2.56
3.9
3.2
0.00
0.00
estimate
0.50
50
293
5
7
7.23
2.55
1.0
1.0
94.20
83.14
%
—
5
7
17
75
2.33
2.55
14.2
5.8
8.35
8.53
kpa
0.17
17
75
8
21
3.87
2.47
2.3
2.9
—
—
—
0
0
9
27
3.39
2.41
1.8
1.3
—
—
—
0
0
48
311
1.63
2.38
3.7
2.5
8.51
7.01
umol/l
0.17
39
270
166
1380
1.39
2.38
5.2
4.4
0.00
0.00
estimate
0.50
48
276
8
22
3.70
2.38
1.1
1.7
—
—
—
0
0
32
187
1.78
2.30
16.9
8.5
8.39
8.39
mmol/l
0.00
32
177
166
1391
1.37
2.22
3.9
3.2
0.00
0.01
estimate
0.50
44
269
5
9
5.62
2.22
2.6
1.8
39.60
67.74
ug/l
—
5
9
86
644
1.45
2.21
2.9
2.5
337.75
5248.22
umol/l
2.16
77
586
12
48
2.55
2.21
1.3
1.4
—
—
—
0
0
12
48
2.55
2.21
1.3
1.4
—
—
—
0
0
36
221
1.70
2.19
4.9
3.7
6.27
5.68
kpa
2.43
36
214
9
30
3.05
2.16
1.0
1.0
—
—
—
0
0
11
42
2.67
2.16
1.5
1.0
—
—
—
0
0
32
192
1.73
2.12
4.6
3.4
3.89
4.82
kpa
2.82
32
187
12
50
2.45
2.05
2.2
3.5
3.51
4.27
e9/l
0.64
12
50
12
50
2.45
2.05
2.5
3.7
58.83
57.02
%
0.21
12
50
337
3258
2.32
2.03
28.9
17.0
4.49
4.51
e12/l
0.47
331
3185
337
3255
2.36
2.02
29.7
17.1
40.15
40.27
%
0.16
327
3093
337
3255
2.36
2.02
29.0
17.0
254.34
259.01
e9/l
0.60
332
3193
6
16
3.80
1.94
1.0
1.0
—
—
—
0
0
251
2272
1.38
1.93
5.2
4.1
14.61
14.47
pmol/l
0.45
232
2105
8
28
2.90
1.87
1.1
1.5
—
—
—
0
0
43
292
1.54
1.78
4.5
4.1
32.00
31.79
%
0.04
32
207
8
30
2.71
1.73
1.1
1.3
—
—
—
0
0
26
158
1.70
1.68
1.8
1.6
—
—
—
0
0
8
31
2.62
1.67
1.1
1.3
—
—
—
0
0
8
31
2.62
1.67
1.1
1.3
—
—
—
0
0
8
31
2.62
1.67
1.1
1.3
—
—
—
0
0
8
31
2.62
1.67
1.6
1.8
—
—
—
0
0
8
31
2.62
1.67
1.1
1.3
—
—
—
0
0
8
31
2.62
1.67
1.1
1.3
—
—
—
0
0
246
2242
1.34
1.66
3.9
3.6
—
—
—
0
0
26
162
1.65
1.54
10.2
4.6
1.62
1.27
mmol/l
0.40
18
125
34
227
1.55
1.53
3.1
4.1
2.30
8.08
ug/l
1.79
22
181
11
51
2.19
1.52
1.3
1.3
—
—
—
0
0
23
140
1.69
1.49
1.8
1.5
—
—
—
0
0
287
2695
1.38
1.46
6.0
4.7
1.84
1.80
mu/l
0.18
264
2512
12
59
2.07
1.45
2.3
1.7
—
—
—
0
0
9
39
2.34
1.44
1.1
1.5
—
—
—
0
0
91
737
1.32
1.43
4.6
3.3
0.00
0.01
estimate
0.80
46
269
22
136
1.66
1.36
1.7
1.7
—
—
—
0
0
9
42
2.17
1.34
1.4
1.4
—
—
—
0
0
9
45
2.03
1.24
1.2
1.5
—
—
—
0
0
9
45
2.03
1.24
1.2
1.5
—
—
—
0
0
9
45
2.03
1.24
1.1
1.1
—
—
—
0
0
11
58
1.93
1.13
1.2
1.5
—
—
—
0
0
81
668
1.28
1.11
5.3
3.8
12.48
11.11
mg/mmol
0.09
58
433
27
186
1.49
1.10
1.0
1.0
—
—
—
0
0
62
494
1.31
1.10
1.7
1.6
456.15
19037130.47
pmol/l
0.50
48
436
90
756
1.26
1.06
1.5
1.3
0.65
1.33
u/ml
1.89
27
209
10
53
1.91
1.02
1.0
1.1
—
—
—
0
0
50
391
1.33
1.01
1.6
1.8
1.54
1.37
%
0.35
42
356
11
61
1.83
0.99
1.2
1.5
—
—
—
0
0
215
1991
1.21
0.95
4.5
2.9
44.48
39.74
u/l
0.39
201
1898
289
2766
1.27
0.90
4.9
3.9
4.62
4.74
mmol/l
1.20
270
2614
8
42
1.93
0.89
1.0
1.8
—
—
—
0
0
6
30
2.02
0.87
1.3
1.5
—
—
—
0
0
6
30
2.02
0.87
1.3
1.5
—
—
—
0
0
18
261
0.67
0.86
1.9
1.6
—
—
—
0
0
123
1091
1.20
0.85
4.2
3.2
—
—
—
0
0
6
31
1.95
0.85
1.0
1.5
—
—
—
0
0
8
46
1.76
0.83
1.6
1.5
7.00
7.40
mmol/l
—
8
39
25
337
0.72
0.81
2.0
1.7
—
—
—
0
0
19
131
1.48
0.80
1.4
1.3
331.00
247.19
miu/ml
0.44
11
68
6
33
1.83
0.79
1.5
1.6
—
—
—
0
0
6
34
1.78
0.76
1.2
1.1
—
—
—
0
0
278
2663
1.22
0.76
4.5
3.5
1.33
1.24
mmol/l
0.47
262
2495
9
53
1.72
0.76
1.1
1.2
—
—
—
0
0
5
24
2.10
0.75
1.4
1.1
—
—
—
0
0
7
38
1.86
0.74
1.1
1.4
—
—
—
0
0
5
25
2.01
0.73
1.0
1.4
—
—
—
0
0
286
2752
1.23
0.72
5.0
3.9
1.42
1.49
mmol/l
2.22
269
2589
291
2806
1.23
0.71
5.3
4.3
2.77
2.84
mmol/l
0.72
273
2635
260
2486
1.18
0.67
5.9
4.9
39.03
38.84
mmol/mol
0.10
238
2349
5
28
1.80
0.66
1.0
1.5
—
—
—
0
0
10
62
1.63
0.65
5.5
3.4
24.43
23.69
mmol/l
—
10
62
63
538
1.21
0.65
2.4
2.0
—
—
—
0
0
25
191
1.33
0.63
1.2
1.4
—
—
—
0
0
6
35
1.73
0.58
1.0
1.2
—
—
—
0
0
6
36
1.68
0.57
1.2
1.1
—
—
—
0
0
6
36
1.68
0.57
2.2
2.4
2.88
4.71
u/ml
—
6
36
31
249
1.27
0.56
1.2
1.4
20.07
22.96
iu/l
0.24
25
218
34
277
1.25
0.55
1.1
1.2
180.38
139.13
iu/ml
0.19
13
108
277
2681
1.17
0.52
4.5
3.9
5.78
5.77
mmol/l
0.04
255
2488
10
142
0.70
0.47
1.4
1.4
—
—
—
0
0
7
49
1.44
0.46
1.3
1.4
—
—
—
0
0
26
318
0.80
0.46
1.7
1.6
—
—
—
0
0
5
31
1.62
0.43
1.2
1.1
—
—
—
0
0
8
57
1.41
0.42
1.1
1.2
—
—
—
0
0
11
150
0.72
0.42
1.5
1.7
3.13
2.77
mg/l
—
6
113
5
33
1.52
0.41
1.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
3.2
—
—
—
0
0
9
66
1.37
0.38
1.4
1.2
—
—
—
0
0
8
113
0.70
0.38
1.6
1.8
—
—
—
0
0
37
320
1.17
0.36
2.9
2.8
0.66
0.76
ug/l
0.28
24
209
66
726
0.89
0.35
1.8
1.6
—
—
—
0
0
17
138
1.24
0.31
1.8
1.5
—
—
—
0
0
60
547
1.12
0.30
4.5
4.6
1.40
2.53
ug/l
1.17
49
494
9
73
1.24
0.25
2.0
1.5
—
—
—
0
0
12
96
1.26
0.25
1.2
1.2
—
—
—
0
0
12
96
1.26
0.25
1.2
1.2
—
—
—
0
0
5
38
1.32
0.23
1.0
1.1
—
—
—
0
0
5
38
1.32
0.23
1.2
1.5
—
—
—
0
0
11
135
0.81
0.22
1.9
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
12
142
0.84
0.18
1.4
1.4
—
—
—
0
0
12
142
0.84
0.18
1.4
1.4
—
—
—
0
0
7
61
1.15
0.17
1.4
1.2
—
—
—
0
0
24
266
0.89
0.16
1.4
1.5
—
—
—
0
0
13
111
1.18
0.16
2.0
1.8
—
—
—
0
0
52
488
1.08
0.16
2.4
1.9
—
—
—
0
0
6
79
0.76
0.15
3.3
1.4
0.14
0.39
nmol/l
—
6
64
12
103
1.17
0.14
1.1
1.3
—
—
—
0
0
8
100
0.80
0.13
1.3
1.5
—
—
—
0
0
70
672
1.05
0.11
1.7
1.4
—
—
—
0
0
5
44
1.14
0.10
1.2
1.4
—
—
—
0
0
16
176
0.90
0.09
1.4
1.5
—
—
—
0
0
10
87
1.15
0.09
1.3
1.4
—
—
—
0
0
5
60
0.83
0.08
1.8
2.0
—
—
—
0
0
14
127
1.11
0.08
2.3
1.9
—
—
—
0
0
13
143
0.91
0.07
1.4
1.4
—
—
—
0
0
12
108
1.12
0.07
4.0
3.6
0.65
0.65
%
0.01
12
108
9
88
1.02
0.07
1.0
1.1
—
—
—
0
0
13
142
0.91
0.06
1.4
1.4
—
—
—
0
0
12
111
1.08
0.04
4.0
3.6
0.91
1.19
%
1.13
12
111
16
153
1.05
0.01
1.3
1.5
—
—
—
0
0
12
114
1.05
0.00
2.2
1.5
—
—
—
0
0
28
281
1.00
0.00
8.7
6.2
—
—
—
0
0
11
105
1.05
0.00
1.6
1.7
—
—
—
0
0
44
436
1.01
0.00
4.0
4.2
25.06
21.80
%
0.33
16
203
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
7
70
1.00
-0.00
1.3
1.5
3.17
3.67
mmol/l
—
7
64
5
51
0.98
-0.00
3.8
2.1
157.60
196.08
ug/min
—
5
29
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
1.28
—
0
7
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_HEREDOTHCLOFACTORS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HEREDOTHCLOFACTORS | 1.209 [0.9, 1.63] | 0.215 |
| Birth year | 0.999 [0.99, 1.01] | 0.889 |
During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 1392 females with D3_HEREDOTHCLOFACTORS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HEREDOTHCLOFACTORS | 1.731 [1.28, 2.33] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 470 males with D3_HEREDOTHCLOFACTORS died.
Mortality risk
Mortality risk for people of age
years, who have D3_HEREDOTHCLOFACTORS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.131% | 0.313% |
| 5 | 0.801% | 2.019% |
| 10 | 2.02% | 4.984% |
| 15 | 3.777% | 8.99% |
| 20 | 6.841% | 15.016% |
Relationships between endpoints
↥Index endpoint: D3_HEREDOTHCLOFACTORS – Hereditary deficiency of other clotting factors
GWS hits: 11
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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