No definition available.
Hereditary deficiency of other clotting factors
DOID EFO Endpoint Browser PheWeb
D3_HEREDOTHCLOFACTORS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
325 |
4. Check minimum number of eventsNone |
325 |
5. Include endpointsNone |
325 |
6. Filter based on genotype QC (FinnGen only) |
325 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D68
- Name in latin
- Deficientia hereditaria aliorum factorum coagulationis
Similar endpoints
↥List of similar endpoints to
Hereditary deficiency of other clotting factors
based on the number of shared cases.
Similar with more cases:
- Other coagulation defects
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2150 | 1552 | 590 |
| Only index persons | 2039 | 1500 | 539 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.02 |
| Only index persons | 0.05 | 0.06 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 36.75 | 32.72 | 47.34 |
| Only index persons | 36.81 | 32.79 | 47.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 325 | 235 | 90 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.04 |
| Median age at first event (years) | 42.72 | 37.12 | 57.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 292
- Matched controls
- 2918
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D68.2
ICD-10 Finland
Hereditary deficiency of other clotting factors
4503599627370496.0
323.0
287
*
D68.8
ICD-10 Finland
Other specified coagulation defects
+∞
117.9
105
*
B01AB05
ATC
enoxaparin; parenteral
7.1
51.9
175
505
B01AA03
ATC
warfarin; systemic
9.6
51.5
120
197
B01AB04
ATC
dalteparin; parenteral
17.1
40.0
65
48
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
16.3
32.9
54
40
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
60.2
32.1
37
7
D68.9
ICD-10 Finland
Coagulation defect, unspecified
+∞
21.1
20
*
D68.0
ICD-10 Finland
Von Willebrand disease
+∞
16.8
16
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
4.8
15.9
56
137
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
4.0
15.6
68
205
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
7.8
15.1
35
50
O28.0
ICD-10 Finland
Abnormal haematological finding on antenatal screening of mother
73.1
12.7
14
*
I80.29
ICD-10 Finland
Phlebitis and thrombophlebitis of other deep vessels of lower extremities
8.6
12.6
27
34
K94
ICPC
Phlebitis/thrombophlebitis
22.4
12.1
17
8
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
17.9
11.3
17
10
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
9.7
10.7
21
23
D68.4
ICD-10 Finland
Acquired coagulation factor deficiency
+∞
9.4
9
*
I82.88
ICD-10 Finland
Embolism and thrombosis of other specified veins
12.0
9.2
16
14
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.2
8.8
129
782
I80.20
ICD-10 Finland
Phlebitis and thrombophlebitis in the iliac vein
51.5
8.7
10
*
N02AX02
ATC
tramadol; systemic, rectal
2.1
8.6
127
770
I82.9
ICD-10 Finland
Embolism and thrombosis of unspecified vein
9.9
8.4
16
17
R06.0
ICD-10 Finland
Dyspnoea
2.4
8.1
76
371
N02BE01
ATC
paracetamol; systemic, rectal
2.5
7.9
251
2075
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
7.7
90
486
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.6
7.5
33
100
I87.0
ICD-10 Finland
Postthrombotic syndrome
82.0
7.4
8
*
B01AB10
ATC
tinzaparin; parenteral
4.0
7.4
29
79
126
Kela drug reimbursment
Chronic coagulation defects
+∞
7.3
7
*
I80.9
ICD-10 Finland
Phlebitis and thrombophlebitis of unspecified site
16.2
7.3
11
7
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
4.9
7.1
22
48
I80.1
ICD-10 Finland
Phlebitis and thrombophlebitis of femoral vein
11.3
6.9
12
11
K99
ICPC
Cardiovascular disease other
8.4
6.4
13
16
M79.6
ICD-10 Finland
Pain in limb
1.9
6.2
113
722
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
6.0
6.2
16
28
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
4.9
6.2
19
41
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
115
311
5.18
41.44
5.7
2.1
34.6
29.8
s
1.66
109
306
154
581
4.14
35.01
4.4
1.8
0.9
0.9
mg/l
0.01
110
449
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
42
55
8.62
30.91
6.9
3.5
0.4
0.4
u/ml
0.14
23
34
80
237
4.15
24.48
42.5
20.3
1.8
1.2
inr
—
6
39
171
1012
2.46
14.15
13.2
6.6
1.2
1.2
mmol/l
0.71
162
930
25
45
5.94
13.58
1.2
1.1
—
—
—
0
0
181
1141
2.32
12.44
9.8
7.1
1.2
1.2
mmol/l
0.35
156
985
83
369
2.68
12.38
4.2
2.4
13.7
13.8
umol/l
0.08
78
337
23
42
5.82
12.30
1.5
1.3
1.9
6.1
u/ml
—
7
15
73
307
2.78
12.11
4.6
2.4
23.5
23.3
%
0.05
65
269
161
996
2.22
11.22
7.5
4.7
36.3
36.4
g/l
0.09
150
937
22
45
5.17
10.42
1.5
1.2
3.5
5.2
u/ml
—
10
19
255
1969
2.37
9.46
8.7
6.7
73.3
76.5
u/l
0.53
241
1847
106
587
2.20
9.40
3.3
2.0
—
—
—
0
0
109
613
2.17
9.28
3.3
2.0
2.6
2.8
mg/l
0.65
91
537
198
1403
2.05
8.92
8.5
4.6
6.4
6.5
mmol/l
0.08
193
1290
51
211
2.68
8.59
3.7
4.2
220.3
234.3
u/l
0.60
46
205
49
199
2.72
8.55
2.9
2.5
77.4
71.0
ml/min/173m2
0.64
31
77
78
410
2.19
7.71
4.0
3.2
298.6
166.8
ng/l
0.37
59
269
210
1567
1.96
7.62
9.0
8.5
4.2
4.0
e9/l
0.37
192
1375
179
1273
1.90
7.44
6.6
5.8
10.1
10.9
umol/l
0.55
171
1216
53
249
2.35
6.79
15.7
6.8
105.3
104.4
mmol/l
1.21
53
239
135
903
1.85
6.57
3.8
3.2
26.2
30.6
u/l
1.92
129
871
6
0
+∞
6.27
1.0
0.0
—
—
—
0
0
10
16
6.42
5.99
1.2
1.3
—
—
—
0
0
73
417
1.97
5.65
4.0
2.6
2.4
2.4
mmol/l
3.62
68
363
12
26
4.75
5.30
1.1
1.2
—
—
—
0
0
164
1219
1.70
5.19
5.0
3.9
—
—
—
0
0
177
1343
1.70
5.19
4.5
2.8
93.3
89.9
ug/l
0.13
165
1262
12
27
4.58
5.08
1.1
1.1
—
—
—
0
0
12
27
4.58
5.08
1.1
1.1
—
—
—
0
0
12
27
4.58
5.08
1.1
1.1
—
—
—
0
0
10
19
5.40
5.07
2.0
2.1
850.2
839.8
e6/l
—
5
6
25
96
2.74
4.85
1.3
1.9
—
—
—
0
0
120
833
1.70
4.81
3.6
3.0
2.3
2.3
mmol/l
2.37
105
746
238
1983
1.75
4.71
5.3
3.8
10.7
10.2
mm/h
0.24
228
1852
11
26
4.34
4.39
1.1
1.2
—
—
—
0
0
297
2674
2.28
4.38
22.6
12.5
139.7
139.6
mmol/l
0.30
291
2608
85
551
1.73
4.31
2.9
3.3
1431.2
1130.3
ng/l
0.33
63
462
61
360
1.85
4.22
3.4
2.5
4.4
2.5
e6/l
0.72
32
189
119
848
1.64
4.21
3.5
3.3
19.5
30.1
ng/l
1.57
65
483
297
2685
2.23
4.15
22.2
12.6
3.9
3.9
mmol/l
0.08
291
2611
125
912
1.60
3.97
2.3
1.8
98.0
96.1
pmol/l
0.18
82
491
43
230
2.00
3.97
1.9
1.7
—
—
—
0
0
80
521
1.71
3.96
1.3
1.2
31.4
30.5
iu/ml
0.02
23
171
10
24
4.27
3.91
1.0
1.3
—
—
—
0
0
20
77
2.70
3.88
3.2
1.8
—
—
—
0
0
106
754
1.60
3.70
2.3
2.5
53.6
53.6
u/l
0.00
101
714
40
214
1.99
3.69
19.3
10.4
1.3
1.4
mmol/l
0.10
33
163
42
231
1.94
3.59
1.9
1.8
—
—
—
0
0
58
354
1.78
3.58
1.9
1.7
—
—
—
0
0
25
112
2.33
3.58
1.8
1.6
—
—
—
0
0
13
41
3.26
3.53
6.0
2.4
16.9
15.8
%
—
8
21
15
52
2.98
3.51
1.5
1.2
—
—
—
0
0
14
47
3.07
3.45
1.5
1.2
318.6
157.5
u/ml
—
9
28
276
2475
1.76
3.35
17.8
10.2
86.9
87.7
ml/min/173m2
0.25
242
1997
93
661
1.57
3.20
4.0
2.6
0.3
0.3
e6/l
0.04
74
482
60
382
1.70
3.19
3.4
2.4
0.8
0.9
e6/l
0.32
31
211
297
2734
2.00
3.16
20.1
11.4
18.9
20.2
mg/l
0.33
246
2099
39
219
1.89
3.14
3.6
3.0
—
—
—
0
0
140
1091
1.50
3.14
3.0
2.4
74.6
74.4
nmol/l
0.03
130
997
17
68
2.58
3.09
1.7
1.4
338.3
322.1
ug/g
0.09
11
40
114
855
1.51
3.05
4.3
2.9
—
—
—
0
0
92
661
1.55
3.00
1.7
1.7
1.4
1.4
mmol/l
0.26
79
573
32
171
1.97
2.98
2.0
2.1
1591.4
3503.7
u/l
0.57
14
67
10
30
3.41
2.93
1.3
1.1
—
—
—
0
0
77
534
1.58
2.92
1.7
1.5
21.2
22.3
nmol/l
0.22
66
463
15
59
2.62
2.83
1.9
2.7
—
—
—
0
0
5
6
8.44
2.76
2.8
2.2
—
—
—
0
0
17
73
2.40
2.70
14.2
5.9
8.3
8.5
kpa
0.17
17
68
72
504
1.55
2.61
1.3
1.2
24.4
7.5
u/ml
0.61
26
212
304
2850
2.03
2.61
13.4
9.0
24.4
25.6
u/l
0.92
297
2773
57
378
1.62
2.59
1.7
1.7
1248.0
1168.5
nmol/l
0.23
44
287
21
102
2.13
2.53
17.4
10.7
24.7
24.5
mmol/l
0.12
21
94
9
26
3.53
2.50
1.8
1.3
—
—
—
0
0
12
47
2.61
2.29
1.3
1.4
—
—
—
0
0
12
47
2.61
2.29
1.3
1.4
—
—
—
0
0
5
9
5.62
2.22
2.6
1.8
39.6
67.7
ug/l
—
5
9
6
14
4.34
2.16
1.0
1.0
—
—
—
0
0
44
288
1.61
2.12
3.9
2.6
8.7
7.2
umol/l
0.17
38
250
81
606
1.45
2.11
3.0
2.5
339.2
5143.7
umol/l
1.95
72
547
7
20
3.55
2.06
1.1
1.6
—
—
—
0
0
34
210
1.69
2.04
5.1
3.6
6.3
5.7
kpa
2.25
34
202
17
84
2.08
1.99
1.8
1.8
3.0
5.5
iu/l
—
8
28
30
181
1.72
1.96
17.9
8.5
8.5
8.5
mmol/l
0.01
30
171
30
182
1.71
1.93
4.8
3.3
3.9
4.7
kpa
2.51
30
176
233
2099
1.39
1.91
3.9
3.6
—
—
—
0
0
153
1293
1.35
1.90
3.7
3.1
0.0
0.0
estimate
0.00
41
260
10
40
2.55
1.85
1.6
1.1
—
—
—
0
0
41
275
1.56
1.80
4.5
4.2
31.5
32.0
%
0.09
31
193
25
148
1.75
1.76
1.8
1.6
—
—
—
0
0
275
2573
1.45
1.62
21.2
12.5
39.8
40.1
%
0.31
219
2055
7
26
2.73
1.59
1.1
1.5
—
—
—
0
0
6
20
3.04
1.59
1.2
2.6
—
—
—
0
0
151
1298
1.31
1.58
5.1
4.3
0.0
0.0
estimate
0.50
44
259
152
1308
1.30
1.58
3.9
3.2
0.0
0.0
estimate
0.50
40
251
234
2140
1.33
1.53
5.2
4.1
14.6
14.5
pmol/l
0.50
218
1986
32
211
1.57
1.53
2.3
2.3
—
18.6
—
0
12
25
155
1.66
1.52
10.5
4.7
1.6
1.3
mmol/l
0.42
18
120
7
28
2.53
1.46
1.1
1.3
—
—
—
0
0
10
46
2.21
1.41
2.4
3.8
60.8
57.1
%
—
10
46
9
40
2.28
1.41
1.4
1.4
—
—
—
0
0
7
29
2.44
1.40
1.1
1.3
—
—
—
0
0
7
29
2.44
1.40
1.0
1.0
—
—
—
0
0
7
29
2.44
1.40
1.1
1.3
—
—
—
0
0
7
29
2.44
1.40
1.1
1.3
—
—
—
0
0
7
29
2.44
1.40
1.1
1.3
—
—
—
0
0
7
29
2.44
1.40
1.1
1.3
—
—
—
0
0
10
47
2.16
1.35
1.3
1.3
—
—
—
0
0
11
54
2.07
1.34
2.5
1.7
—
—
—
0
0
20
121
1.70
1.34
1.7
1.6
—
—
—
0
0
25
162
1.59
1.30
10.5
4.6
5.3
5.1
kpa
0.95
25
154
8
36
2.25
1.25
1.1
1.5
—
—
—
0
0
268
2526
1.35
1.24
6.1
4.7
1.8
1.8
mu/l
0.02
247
2361
86
706
1.30
1.23
1.5
1.3
0.6
1.4
u/ml
1.97
25
197
84
692
1.29
1.17
4.5
3.3
0.0
0.0
estimate
0.80
42
254
8
40
2.02
1.13
1.0
1.9
—
—
—
0
0
25
170
1.51
1.08
1.0
1.0
—
—
—
0
0
30
214
1.44
1.04
3.3
4.1
2.4
8.5
ug/l
1.72
20
168
5
22
2.29
1.03
1.0
1.5
—
—
—
0
0
5
22
2.29
1.03
1.4
1.1
—
—
—
0
0
10
53
1.91
1.02
1.2
1.5
—
—
—
0
0
7
35
2.02
1.00
1.1
1.4
—
—
—
0
0
20
132
1.55
0.99
1.9
1.5
—
—
—
0
0
9
49
1.86
0.99
1.0
1.1
—
—
—
0
0
6
29
2.09
0.89
1.0
1.5
—
—
—
0
0
75
630
1.25
0.89
5.9
3.9
12.9
10.5
mg/mmol
0.17
56
403
10
56
1.81
0.88
1.2
1.5
—
—
—
0
0
201
1864
1.21
0.88
4.6
2.9
44.3
39.1
u/l
0.41
189
1779
25
179
1.43
0.87
1.2
1.3
—
—
—
0
0
8
44
1.84
0.86
1.1
1.1
—
—
—
0
0
6
31
1.95
0.85
1.5
1.5
—
—
—
0
0
6
31
1.95
0.85
1.2
1.1
—
—
—
0
0
271
2598
1.26
0.80
4.9
3.9
4.6
4.7
mmol/l
1.29
253
2455
6
33
1.83
0.79
1.0
1.2
—
—
—
0
0
6
33
1.83
0.79
1.2
1.1
—
—
—
0
0
18
123
1.49
0.79
1.4
1.3
331.0
243.1
miu/ml
0.47
11
64
5
25
2.02
0.73
1.0
1.4
—
—
—
0
0
261
2500
1.22
0.73
4.6
3.5
1.3
1.2
mmol/l
0.36
246
2347
10
60
1.69
0.73
5.5
3.4
24.4
23.6
mmol/l
—
10
52
56
469
1.23
0.70
1.8
1.6
452.9
20146074.5
pmol/l
0.50
44
412
262
2517
1.21
0.67
4.4
3.9
5.8
5.8
mmol/l
0.09
241
2339
5
28
1.80
0.66
1.2
1.1
—
—
—
0
0
23
301
0.75
0.64
2.2
1.7
—
—
—
0
0
268
2583
1.21
0.64
5.0
3.9
1.4
1.5
mmol/l
1.98
252
2432
5
29
1.74
0.64
2.0
1.8
—
—
—
0
0
273
2637
1.22
0.63
5.3
4.3
2.8
2.8
mmol/l
0.94
256
2476
44
364
1.24
0.62
1.6
1.8
1.6
1.4
%
0.54
37
331
8
51
1.58
0.61
1.0
1.1
—
—
—
0
0
17
231
0.72
0.61
2.0
1.6
—
—
—
0
0
243
2328
1.17
0.59
6.1
5.0
39.3
38.8
mmol/mol
0.25
223
2204
57
492
1.19
0.54
2.3
2.0
—
—
—
0
0
9
135
0.66
0.53
1.3
1.4
—
—
—
0
0
10
67
1.51
0.50
2.4
1.5
15.2
23.5
u/l
—
10
54
111
1025
1.13
0.44
4.1
3.2
—
—
—
0
0
35
298
1.20
0.40
3.1
2.9
0.7
0.8
ug/l
0.20
22
200
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
3.2
—
—
—
0
0
8
61
1.32
0.40
1.5
1.2
—
—
—
0
0
12
89
1.36
0.38
1.2
1.2
—
—
—
0
0
12
89
1.36
0.38
1.2
1.2
—
—
—
0
0
5
37
1.36
0.37
1.0
1.2
—
—
—
0
0
9
70
1.29
0.37
2.0
1.5
—
—
—
0
0
5
76
0.65
0.36
3.6
1.4
0.1
0.4
nmol/l
—
5
62
6
46
1.31
0.33
1.3
1.5
—
—
—
0
0
28
239
1.19
0.32
1.1
1.4
20.4
23.2
iu/l
0.21
22
209
30
258
1.18
0.32
1.1
1.2
218.5
138.5
iu/ml
—
10
103
7
55
1.28
0.30
1.1
1.2
—
—
—
0
0
56
510
1.12
0.28
4.7
4.8
1.4
2.6
ug/l
1.19
46
460
11
140
0.78
0.28
1.5
1.7
3.1
2.6
mg/l
—
6
101
16
131
1.23
0.27
1.9
1.5
—
—
—
0
0
26
295
0.87
0.23
1.7
1.6
—
—
—
0
0
14
116
1.22
0.22
2.3
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
8
101
0.79
0.21
1.9
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
10
122
0.81
0.19
2.0
1.6
—
—
—
0
0
7
58
1.21
0.18
1.4
1.2
—
—
—
0
0
11
91
1.22
0.18
1.1
1.2
—
—
—
0
0
63
663
0.94
0.14
1.8
1.6
—
—
—
0
0
7
89
0.78
0.14
1.3
1.5
—
—
—
0
0
12
103
1.17
0.14
4.0
3.6
0.9
1.2
%
1.33
12
103
12
103
1.17
0.14
1.9
1.8
—
—
—
0
0
11
125
0.88
0.10
1.5
1.4
—
—
—
0
0
11
125
0.88
0.10
1.5
1.4
—
—
—
0
0
5
46
1.09
0.09
4.6
2.2
157.6
216.3
ug/min
—
5
26
12
107
1.13
0.08
2.2
1.5
—
—
—
0
0
7
64
1.10
0.08
1.3
1.6
3.2
3.6
mmol/l
—
7
58
9
84
1.07
0.07
1.3
1.4
—
—
—
0
0
46
449
1.03
0.03
2.2
1.8
—
—
—
0
0
14
134
1.05
0.00
1.3
1.5
—
—
—
0
0
26
266
0.98
0.00
8.4
6.4
—
—
—
0
0
10
97
1.03
0.00
1.6
1.7
—
—
—
0
0
15
153
0.98
0.00
1.4
1.5
—
—
—
0
0
41
407
1.01
0.00
4.2
4.3
25.9
21.4
%
0.47
15
194
63
627
1.01
0.00
1.7
1.5
—
—
—
0
0
12
125
0.96
0.00
1.4
1.4
—
—
—
0
0
12
125
0.96
0.00
1.4
1.4
—
—
—
0
0
23
234
0.98
0.00
1.4
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
5
57
0.88
0.00
1.8
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
1.3
—
0
7
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
8
85
0.94
0.00
1.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_HEREDOTHCLOFACTORS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HEREDOTHCLOFACTORS | 1.209 [0.9, 1.63] | 0.215 |
| Birth year | 0.999 [0.99, 1.01] | 0.889 |
During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 1392 females with D3_HEREDOTHCLOFACTORS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HEREDOTHCLOFACTORS | 1.731 [1.28, 2.33] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 470 males with D3_HEREDOTHCLOFACTORS died.
Mortality risk
Mortality risk for people of age
years, who have D3_HEREDOTHCLOFACTORS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.131% | 0.313% |
| 5 | 0.801% | 2.019% |
| 10 | 2.02% | 4.984% |
| 15 | 3.777% | 8.99% |
| 20 | 6.841% | 15.016% |
Relationships between endpoints
↥Index endpoint: D3_HEREDOTHCLOFACTORS – Hereditary deficiency of other clotting factors
GWS hits: 13
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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