cirrhosis of liver: A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
253 |
4. Check minimum number of eventsNone |
253 |
5. Include endpointsNone |
253 |
6. Filter based on genotype QC (FinnGen only) |
244 |
Control definitions (FinnGen only)
- Control exclude
- CIRRHOSIS_BROAD
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K74
- Name in latin
- Fibrosis hepatis
Similar endpoints
↥List of similar endpoints to
Fibrosis of liver
based on the number of shared cases.
Similar with more cases:
- Fibrosis and cirrhosis of liver
- Cirrhosis, broad definition used in the article https://doi.org/10.1101/594523
- Diseases of liver
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1501 | 735 | 747 |
| Only index persons | 1232 | 625 | 607 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 59.22 | 59.75 | 58.57 |
| Only index persons | 58.22 | 58.24 | 58.20 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 244 | 124 | 120 |
| Unadjusted period prevalence (%) | 0.05 | 0.04 | 0.05 |
| Median age at first event (years) | 58.89 | 56.35 | 61.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 253
- Matched controls
- 2530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K74.0
ICD-10 Finland
Hepatic fibrosis
+∞
307.7
253
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
56.6
114.9
67
16
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
63.6
90.4
51
10
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
+∞
85.3
77
*
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
27.6
80.4
58
27
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
11.7
72.3
92
118
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
7.3
55.5
162
495
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
17.9
43.4
37
24
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
+∞
36.3
34
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.1
35.6
78
173
C03DA01
ATC
spironolactone; oral
5.6
30.7
71
164
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
4.6
30.4
108
354
A05AA02
ATC
ursodeoxycholic acid; oral
32.6
29.9
39
14
103
Kela drug reimbursment
Diabetes, insulin-treated
4.4
29.6
119
427
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
+∞
28.7
27
*
L04AX01
ATC
azathioprine; systemic
9.2
27.6
36
45
215
Kela drug reimbursment
Diabetes, non-insulin-treated
3.9
23.8
107
404
A10BA02
ATC
metformin; oral
3.8
23.5
115
459
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
251.9
23.0
23
*
C03CA01
ATC
furosemide; systemic
3.7
23.0
112
445
R18
ICD-10 Finland
Ascites
23.3
21.9
31
15
A10AE04
ATC
insulin glargine; parenteral
4.8
21.1
55
138
K76.9
ICD-10 Finland
Liver disease, unspecified
28.4
20.9
28
11
N17.9
ICD-10 Finland
Acute renal failure, unspecified
9.0
20.9
27
33
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
6.0
20.1
39
75
T90
ICPC
Diabetes non-insulin dependent
3.5
20.0
99
391
D64.9
ICD-10 Finland
Anaemia, unspecified
4.6
18.9
51
131
JN3AD
NOMESCO Finland
Abdominal CT examination
4.3
18.3
55
153
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
22.1
18.2
26
13
K74.3
ICD-10 Finland
Primary biliary cirrhosis
102.3
17.8
19
*
A41.9
ICD-10 Finland
Sepsis, unspecified
8.0
17.7
25
34
A10BH01
ATC
sitagliptin; oral
4.4
17.3
50
135
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
5.1
17.0
39
87
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
+∞
16.9
16
*
Z94.4
ICD-10 Finland
Liver transplant status
96.6
16.8
18
*
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
181.5
16.7
17
*
JJC00
NOMESCO Finland
Allogenic transplantation of liver
181.5
16.7
17
*
127
Kela drug reimbursment
Transplant complication
28.4
15.9
21
8
SPAT1262
SPAT
Handing over of treatment supplies
3.4
15.5
69
250
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
4.0
15.3
50
147
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
12.5
14.7
26
23
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
+∞
13.7
13
*
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
22.7
13.5
19
9
E66.00
ICD-10 Finland
Metabolic syndrome
5.2
13.4
29
61
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
4.7
13.4
33
78
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.8
13.3
32
74
C07AG02
ATC
carvedilol; oral
5.0
13.2
30
66
A10BJ06
ATC
semaglutide; parenteral
5.2
13.2
29
62
K70.0
ICD-10 Finland
Alcoholic fatty liver
+∞
12.6
12
*
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
136.5
12.6
13
*
UJF30
NOMESCO Finland
Ileoscopy through colon
3.6
12.4
46
147
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.5
12.4
48
158
L04AD02
ATC
tacrolimus; systemic
49.1
12.0
14
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
11.7
145
879
K83.0
ICD-10 Finland
Cholangitis
14.6
11.7
19
14
K72.1
ICD-10 Finland
Chronic hepatic failure
+∞
11.5
11
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.0
11.5
61
242
K73.80
ICD-10 Finland
Non-alcoholic fatty liver (NASH, Non Alcoholic Steatohepatitis)
45.4
11.0
13
*
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
10.3
11.0
21
22
L04AA06
ATC
mycophenolic acid; systemic
13.7
10.8
18
14
D97
ICPC
Liver disease NOS
62.7
10.7
12
*
K29.3
ICD-10 Finland
Chronic superficial gastritis
5.8
10.6
20
37
K70.4
ICD-10 Finland
Alcoholic hepatic failure
114.6
10.5
11
*
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
34.1
10.4
13
*
A06AD11
ATC
lactulose; oral
3.2
10.3
47
170
A10AB05
ATC
insulin aspart; parenteral
3.6
10.3
37
115
J01MA02
ATC
ciprofloxacin; systemic
2.4
10.3
118
679
R04.0
ICD-10 Finland
Epistaxis
3.8
10.3
33
95
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
5.6
10.3
20
38
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
12.0
10.2
18
16
N30.0
ICD-10 Finland
Acute cystitis
3.1
9.7
47
176
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
9.5
103
574
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
4.8
9.5
22
49
L04AD01
ATC
ciclosporin; systemic
11.3
9.4
17
16
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
+∞
9.4
9
*
A07AA11
ATC
rifaximin; oral
+∞
9.4
9
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.9
9.3
49
192
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
9.3
106
603
K72.9
ICD-10 Finland
Hepatic failure, unspecified
38.2
9.1
11
*
K92.1
ICD-10 Finland
Melaena
4.3
9.0
24
60
A02BC02
ATC
pantoprazole; systemic
2.5
9.0
189
1379
WX872
NOMESCO Finland
Intensive care
4.2
8.9
25
65
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
4.2
8.9
25
65
XW000
NOMESCO Finland
Bone marrow biopsy
4.7
8.8
21
48
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
51.8
8.7
10
*
UJF32
NOMESCO Finland
Coloscopy
2.4
8.7
83
435
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.7
8.6
29
86
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.6
8.6
21
49
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.3
8.5
84
447
JJ5AT, ,
NOMESCO Finland
+∞
8.4
8
*
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
+∞
8.4
8
*
K74.2
ICD-10 Finland
Hepatic fibrosis with hepatic sclerosis
+∞
8.4
8
*
A07EA06
ATC
budesonide; oral, local oral
4.6
8.3
20
46
H02AB06
ATC
prednisolone; systemic
2.2
8.3
135
876
A10BB12
ATC
glimepiride; oral
3.6
8.2
29
89
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.7
8.2
48
199
K29.6
ICD-10 Finland
Other gastritis
17.9
8.2
12
7
WW500
NOMESCO Finland
Blood transfusion
4.5
8.1
20
47
WX892
NOMESCO Finland
Monitored bed care
3.4
8.0
30
96
ZXE40
NOMESCO Finland
More than seven and less than nine hours
7.8
7.8
17
23
B18.2
ICD-10 Finland
Chronic viral hepatitis C
15.7
7.8
12
8
K74.5
ICD-10 Finland
Biliary cirrhosis, unspecified
46.4
7.8
9
*
TK800
NOMESCO Finland
Hemodialysis
8.5
7.7
16
20
C07AA05
ATC
propranolol; systemic
2.4
7.6
65
322
A10BX07
ATC
[U] liraglutide
10.5
7.6
14
14
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
10.5
7.6
14
14
R11
ICD-10 Finland
Nausea and vomiting
3.1
7.6
34
121
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
13.9
7.5
12
9
205
Kela drug reimbursment
Chronic hypertension
2.2
7.4
77
414
160
Kela drug reimbursment
exenatide
6.6
7.4
18
29
K92.0
ICD-10 Finland
Haematemesis
9.8
7.4
14
15
8170/3-C22.0
ICD-O-3
Hepatocellular carcinoma, NOS, of liver
+∞
7.3
7
*
E66.8
ICD-10 Finland
Other obesity
4.2
7.3
20
51
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.7
7.3
17
38
R50.9
ICD-10 Finland
Fever, unspecified
2.5
7.3
50
224
WX882
NOMESCO Finland
High dependency care
6.9
7.2
17
26
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
31.0
7.2
9
*
N02AX02
ATC
tramadol; systemic, rectal
2.0
7.2
126
827
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.3
7.1
28
92
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
7.3
7.1
16
23
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.7
7.0
40
163
TPH07
NOMESCO Finland
Cathetrisation of artery
2.7
6.9
41
171
162
Kela drug reimbursment
liraglutide
9.7
6.9
13
14
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.1
6.9
86
497
WX402
NOMESCO Finland
General anaesthesia
2.2
6.8
69
366
K75.4
ICD-10 Finland
Autoimmune hepatitis
41.2
6.8
8
*
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
6.8
6.8
16
25
RS220, ,
NOMESCO Finland
23.2
6.7
9
*
E66.01
ICD-10 Finland
Obesity due to excess calories
2.9
6.5
33
126
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.8
6.5
20
56
XF622
NOMESCO Finland
Measurement of minute volume of heart
71.6
6.5
7
*
R16.1
ICD-10 Finland
Splenomegaly, not elsewhere classified
71.6
6.5
7
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.5
6.5
23
71
I50.0
ICD-10 Finland
Congestive heart failure
3.5
6.5
23
71
A10BH05
ATC
linagliptin; oral
3.7
6.4
21
61
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
8.5
6.4
13
16
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
6.4
67
360
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
11.4
6.4
11
10
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.4
6.3
23
72
JJA21
NOMESCO Finland
Laparoscopic biopsy of liver
+∞
6.3
6
*
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
+∞
6.3
6
*
K76.7
ICD-10 Finland
Hepatorenal syndrome
+∞
6.3
6
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.7
6.2
35
142
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
7.0
6.1
14
21
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
6.0
66
360
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
141
208
14.05
103.28
6.2
2.4
0.19
0.23
g/l
6.61
136
196
102
141
11.45
76.07
1.6
1.7
1.31
1.36
g/l
0.07
96
129
48
18
32.68
71.58
1.5
1.3
—
—
—
0
0
116
306
6.15
44.92
3.2
2.2
2.41
2.31
g/l
0.81
106
280
112
287
6.21
44.75
3.1
2.3
24.52
22.62
%
0.49
95
238
101
247
6.14
42.16
2.2
1.7
1.60
1.51
%
0.67
83
212
192
996
4.85
28.05
21.5
11.4
1.29
1.22
inr
0.58
68
300
148
682
3.82
24.53
4.7
2.4
57.79
64.63
u/l
0.43
143
627
64
174
4.59
22.25
17.7
6.8
9.66
9.73
mmol/l
0.02
64
167
117
490
3.58
21.91
3.5
2.1
3.68
3.03
mg/l
1.73
107
422
79
259
3.98
21.28
12.6
6.1
1.09
1.05
mmol/l
0.55
79
242
30
41
8.17
21.26
1.5
1.1
297.40
234.55
u/ml
0.41
15
22
30
43
7.78
20.40
1.5
1.2
—
—
—
0
0
162
873
3.38
19.43
4.8
2.6
160.79
127.23
ug/l
0.94
156
804
35
66
5.99
18.36
7.4
3.7
1.61
1.42
mg/l
0.72
35
61
133
654
3.18
18.35
5.1
3.7
12.94
9.57
mg/mmol
0.25
89
398
177
1031
3.39
18.14
15.0
7.1
1.20
1.21
mmol/l
2.31
152
881
219
1462
4.71
18.08
12.0
3.1
164.06
48.05
u/l
8.08
214
1375
166
944
3.21
17.47
12.3
6.2
1.19
1.22
mmol/l
3.19
161
869
132
664
3.07
17.21
5.3
3.0
6.51
7.66
mmol/l
2.94
117
545
168
1001
3.02
15.55
12.5
6.1
28.10
28.11
%
0.00
162
946
59
194
3.66
15.41
9.6
4.6
1.49
1.84
mmol/l
0.31
47
159
166
989
2.97
15.25
11.8
5.9
57.54
56.65
%
0.48
158
934
26
46
6.19
14.46
2.0
1.3
—
—
—
0
0
24
40
6.52
14.13
1.7
1.3
103.29
97.36
u/ml
—
7
11
21
13
17.48
13.71
8.6
2.8
81.86
94.08
%
0.44
21
13
185
1231
2.87
12.72
15.6
9.7
3.65
4.03
e9/l
1.95
171
1084
27
56
5.28
12.69
1.6
1.3
—
—
—
0
0
188
1285
2.80
11.84
10.5
4.8
7.52
6.65
mmol/l
4.31
180
1210
87
420
2.63
11.29
1.8
1.7
440.56
468.42
pmol/l
0.37
75
349
16
9
18.85
10.87
1.0
1.1
—
—
—
0
0
18
14
13.74
10.83
2.8
1.4
0.85
1.07
g/l
0.82
18
14
23
30
8.32
10.65
1.7
1.4
—
—
—
0
0
58
234
2.92
10.56
3.6
4.2
3.13
25.97
ug/l
0.68
50
193
94
485
2.49
10.50
1.3
1.3
1.09
1.65
u/ml
0.55
27
132
43
146
3.34
10.49
2.1
1.5
—
—
—
0
0
71
323
2.67
10.27
2.4
1.9
—
—
—
0
0
135
825
2.36
10.24
2.5
1.9
89.13
95.15
pmol/l
0.88
91
421
76
362
2.57
9.98
2.3
1.6
1272.48
1188.42
nmol/l
0.32
63
280
13
5
27.26
9.91
3.1
2.6
44384.62
28861.00
ug/l
—
13
5
23
53
4.67
9.55
2.3
2.0
—
—
—
0
0
56
235
2.78
9.41
9.1
8.4
0.82
1.34
mmol/l
0.32
39
194
39
140
3.11
8.64
6.8
3.2
1.34
1.70
mmol/l
0.14
28
106
98
562
2.21
8.21
4.9
2.9
375.53
5924.43
umol/l
2.21
88
480
57
261
2.53
7.97
8.0
7.6
104.30
103.97
mmol/l
0.16
57
261
23
63
3.92
7.65
1.3
1.2
—
—
—
0
0
144
995
2.04
7.07
5.0
2.5
—
—
—
0
0
80
446
2.16
7.02
3.0
1.8
1.46
1.30
mg/l
0.21
68
356
36
140
2.83
6.90
15.4
8.1
23.23
25.13
mmol/l
2.35
36
140
87
508
2.09
6.73
4.3
2.3
—
—
—
0
0
84
487
2.09
6.60
1.9
1.6
20.75
20.56
nmol/l
0.03
76
413
47
216
2.44
6.45
3.7
2.3
45.24
35.86
u/l
0.38
42
185
99
618
1.99
6.29
3.9
2.9
1105.16
960.15
ng/l
0.24
80
521
200
1597
2.20
6.20
7.2
4.0
20.80
11.44
mm/h
7.75
193
1466
21
63
3.54
6.15
2.3
1.5
—
—
—
0
0
19
54
3.72
6.01
1.9
1.7
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
20
59
3.59
6.00
3.8
2.0
0.26
0.37
u/ml
1.04
14
29
19
55
3.65
5.85
1.9
1.7
—
—
—
0
0
115
771
1.90
5.81
5.0
3.0
—
—
—
0
0
12
17
7.35
5.50
1.0
1.0
—
—
—
0
0
19
59
3.40
5.29
2.3
2.4
157.24
105.94
ug/min
0.21
12
33
16
35
4.81
5.28
4.2
2.4
2.83
5.23
e9/l
3.79
16
35
97
631
1.87
5.27
2.8
2.1
362.58
175.33
u/l
0.84
90
592
27
104
2.79
5.26
3.9
3.8
1.26
1.18
%
0.18
27
104
21
70
3.18
5.24
2.2
1.9
—
—
—
0
0
47
237
2.21
5.18
2.4
1.8
—
—
—
0
0
16
36
4.67
5.15
4.3
2.9
53.13
60.75
%
1.32
16
36
10
12
8.62
5.11
1.2
1.6
—
—
—
0
0
26
101
2.75
4.98
3.9
3.9
0.68
0.67
%
0.07
26
101
16
46
3.65
4.98
8.3
2.4
4.68
4.93
kpa
0.70
16
46
9
10
9.28
4.82
1.3
1.2
113.67
83.71
u/l
—
9
10
9
10
9.28
4.82
1.3
1.2
52.67
25.57
u/l
—
9
10
19
63
3.18
4.78
10.4
2.5
9.24
8.32
kpa
0.83
19
63
12
22
5.67
4.66
2.3
1.9
—
—
—
0
0
12
22
5.67
4.66
2.3
1.9
—
—
—
0
0
9
11
8.43
4.60
2.8
2.6
—
—
—
0
0
45
236
2.10
4.47
2.3
1.8
—
—
—
0
0
9
12
7.73
4.39
1.2
1.6
—
—
—
0
0
21
78
2.85
4.37
1.7
1.8
—
—
—
0
0
137
1029
1.72
4.34
5.4
3.4
0.00
0.00
estimate
-0.00
32
205
36
176
2.22
4.26
2.5
2.9
60.32
66.59
ml/min/173m2
0.36
19
78
14
41
3.56
4.25
2.0
1.7
—
—
—
0
0
111
791
1.72
4.23
5.0
3.6
24.13
34.95
ng/l
1.28
86
564
14
35
4.17
4.17
2.1
1.9
—
—
—
0
0
14
35
4.17
4.17
2.1
1.9
—
—
—
0
0
19
71
2.81
3.92
1.6
1.8
13.53
10.20
g/l
1.51
19
66
40
211
2.06
3.91
4.9
3.4
—
—
—
0
0
14
44
3.31
3.84
1.6
1.6
—
—
—
0
0
87
597
1.70
3.71
5.3
2.9
0.60
0.38
e6/l
0.45
73
433
8
12
6.84
3.70
2.0
1.8
—
—
—
0
0
15
52
3.00
3.53
2.9
2.2
23.58
24.54
mmol/l
0.22
15
52
133
1030
1.61
3.46
6.9
4.8
0.00
0.00
estimate
-0.00
31
198
12
32
3.88
3.44
2.3
1.5
—
—
—
0
0
17
66
2.69
3.29
2.2
1.7
—
—
—
0
0
9
20
4.62
3.14
2.3
1.4
—
—
—
0
0
25
120
2.20
3.11
1.7
1.6
—
—
—
0
0
16
63
2.64
3.02
1.8
2.1
0.49
0.85
g/l
0.24
16
58
17
70
2.53
2.95
3.9
2.8
—
—
—
0
0
8
17
4.82
2.94
1.0
1.2
—
—
—
0
0
12
38
3.26
2.89
1.3
1.7
—
—
—
0
0
10
28
3.67
2.81
1.2
1.9
—
—
—
0
0
131
1044
1.53
2.80
5.6
3.5
0.00
0.00
estimate
-0.00
26
188
9
23
4.02
2.80
1.4
1.3
—
—
—
0
0
11
34
3.33
2.76
1.2
1.7
—
—
—
0
0
8
19
4.31
2.70
1.1
1.2
—
—
—
0
0
12
43
2.88
2.68
2.6
2.4
15.20
15.99
%
—
5
22
12
43
2.88
2.68
1.0
1.4
—
—
—
0
0
11
35
3.24
2.68
1.6
1.6
—
—
—
0
0
11
35
3.24
2.68
1.8
1.4
—
—
—
0
0
14
55
2.64
2.66
1.4
1.4
—
—
—
0
0
9
25
3.69
2.60
1.2
2.0
—
—
—
0
0
9
25
3.69
2.60
2.4
1.4
—
—
—
0
0
61
416
1.61
2.57
3.8
3.6
335.07
157.53
ng/l
0.47
43
323
6
11
5.56
2.56
1.3
1.5
—
—
—
0
0
6
11
5.56
2.56
1.3
1.5
—
—
—
0
0
231
2127
1.99
2.51
33.5
13.8
18.26
23.09
mg/l
2.69
215
1677
14
57
2.54
2.49
1.2
1.4
274.20
279.47
miu/ml
—
5
25
104
806
1.49
2.46
5.8
3.6
—
—
—
0
0
17
77
2.29
2.43
1.5
1.8
—
—
—
0
0
52
346
1.63
2.41
3.4
2.8
8.01
2.21
e6/l
0.64
33
181
13
52
2.58
2.40
1.0
1.2
—
1.04
—
0
5
5
8
6.35
2.38
1.2
1.0
—
—
—
0
0
55
374
1.60
2.33
3.3
2.6
0.79
0.89
e6/l
0.16
36
207
13
53
2.53
2.31
1.0
1.2
—
—
—
0
0
7
18
3.97
2.27
1.1
1.2
—
—
—
0
0
6
14
4.36
2.16
1.3
1.6
9.17
12.43
umol/l
—
6
14
76
567
1.49
2.12
6.4
3.5
0.00
0.02
estimate
0.50
28
190
5
10
5.08
2.08
1.0
1.1
451.74
230.85
iu/ml
—
5
10
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
5
10
5.08
2.08
1.6
2.1
151.80
138.30
%
—
5
10
9
32
2.88
2.02
1.1
1.5
—
—
—
0
0
9
32
2.88
2.02
1.2
1.5
—
—
—
0
0
6
17
3.59
1.85
4.0
2.6
—
—
—
0
0
5
12
4.23
1.83
1.0
1.3
14.28
8.53
ug/l
—
5
12
216
1996
1.56
1.73
10.4
5.7
43.81
40.02
mmol/mol
3.70
207
1862
50
356
1.50
1.73
1.5
1.3
18.40
9.35
u/ml
0.36
22
137
5
13
3.90
1.72
1.8
2.9
—
—
—
0
0
7
25
2.85
1.66
2.4
1.4
—
—
—
0
0
219
2036
1.56
1.63
5.6
4.1
1.48
1.28
mmol/l
3.14
203
1876
5
14
3.62
1.62
1.8
1.8
110.80
76.21
umol/l
—
5
14
8
32
2.55
1.61
1.3
1.5
—
—
—
0
0
8
32
2.55
1.61
1.3
1.5
—
—
—
0
0
226
2118
1.63
1.61
6.1
4.6
4.30
4.68
mmol/l
5.41
211
1975
6
20
3.05
1.59
1.0
1.1
—
—
—
0
0
8
33
2.47
1.55
1.3
1.5
—
—
—
0
0
8
33
2.47
1.55
1.4
1.3
—
—
—
0
0
8
33
2.47
1.55
1.4
1.3
—
—
—
0
0
8
33
2.47
1.55
1.3
1.5
—
—
—
0
0
6
23
2.65
1.37
1.0
1.2
—
—
—
0
0
6
23
2.65
1.37
1.3
2.2
548.67
536.06
e6/l
—
6
18
176
1595
1.34
1.33
4.8
3.8
14.97
14.74
pmol/l
0.57
167
1442
223
2102
1.51
1.32
5.9
4.6
1.31
1.46
mmol/l
5.93
208
1949
10
48
2.13
1.29
2.2
1.4
—
—
—
0
0
10
189
0.51
1.28
1.6
1.7
—
—
—
0
0
8
35
2.33
1.28
1.0
1.1
—
—
—
0
0
19
116
1.69
1.25
2.7
2.8
4.12
4.52
pmol/l
0.92
14
105
149
1330
1.29
1.20
2.7
2.9
—
—
—
0
0
35
473
0.70
1.17
2.6
2.9
0.86
0.75
ug/l
0.33
25
311
5
20
2.53
1.15
1.2
1.4
—
—
—
0
0
5
21
2.41
1.09
1.2
1.3
—
—
—
0
0
5
21
2.41
1.09
1.2
1.4
—
—
—
0
0
207
1947
1.35
1.04
5.8
4.6
1.86
1.94
mu/l
0.40
198
1774
7
34
2.09
1.03
1.4
1.8
—
—
—
0
0
58
465
1.32
1.03
6.1
3.7
1.01
1.02
kg/l
1.12
12
64
9
48
1.91
1.01
1.3
1.3
—
—
—
0
0
235
2261
1.55
1.00
38.2
16.3
81.66
77.25
umol/l
1.07
235
2261
225
2152
1.41
0.93
6.6
5.1
2.48
2.78
mmol/l
5.18
212
1992
6
28
2.17
0.92
1.8
2.9
109.17
106.64
mmol/l
—
6
28
6
28
2.17
0.92
2.0
4.1
—
—
—
0
0
8
43
1.89
0.88
2.4
1.6
1964.38
3055.13
e6/l
—
8
31
8
43
1.89
0.88
2.3
1.4
28.63
5.38
e6/l
—
8
29
8
48
1.69
0.79
1.4
1.3
—
—
—
0
0
47
381
1.29
0.78
1.6
1.3
36.37
33.94
iu/ml
0.07
21
128
7
38
1.87
0.74
1.4
1.1
—
—
—
0
0
8
52
1.56
0.60
2.0
1.3
—
—
—
0
0
43
364
1.22
0.52
1.6
1.6
—
—
—
0
0
87
789
1.16
0.48
4.4
4.8
2.01
2.04
ug/l
0.02
81
707
10
69
1.47
0.45
1.6
1.6
—
—
—
0
0
5
32
1.57
0.42
1.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
6.9
—
35.80
—
0
5
0
18
0.00
0.40
0.0
1.0
—
543.90
—
0
10
0
18
0.00
0.40
0.0
1.0
—
44.79
—
0
8
58
646
0.87
0.39
4.1
4.2
24.48
21.23
%
0.63
24
305
5
37
1.36
0.37
1.2
1.7
—
—
—
0
0
67
631
1.08
0.19
1.7
1.7
1.54
1.39
mmol/l
0.41
56
532
14
163
0.85
0.18
1.6
2.0
—
—
—
0
0
205
2018
1.08
0.16
28.7
12.8
78.37
81.52
ml/min/173m2
1.03
181
1672
16
181
0.88
0.14
2.1
2.4
14.44
13.60
nmol/l
0.14
16
167
10
118
0.84
0.14
1.3
1.3
—
—
—
0
0
15
132
1.14
0.13
2.3
1.4
—
—
—
0
0
211
2086
1.07
0.11
6.5
4.6
6.76
5.97
mmol/l
6.05
199
1921
6
55
1.09
0.09
1.2
1.3
—
—
—
0
0
6
58
1.04
0.08
1.2
1.1
—
—
—
0
0
28
264
1.07
0.08
15.7
6.8
—
—
—
0
0
7
67
1.05
0.08
1.3
1.2
—
—
—
0
0
7
68
1.03
0.08
1.3
1.2
—
—
—
0
0
17
184
0.92
0.07
1.6
2.0
—
—
—
0
0
12
121
0.99
0.00
1.1
1.0
—
—
—
0
0
236
2361
0.99
0.00
51.5
20.5
38.03
40.50
%
4.97
215
2225
28
283
0.99
0.00
1.3
1.5
—
—
—
0
0
8
85
0.94
0.00
2.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
99.29
—
0
7
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
59
0.84
-0.00
1.2
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
7.82
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
6
66
0.91
-0.00
2.5
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
69
0.87
-0.00
1.5
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
66.76
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint FIBROLIV and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FIBROLIV | 3.993 [3.15, 5.06] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.94 |
During the follow-up period (1.1.1998 — 31.12.2019), 199 out of 599 females with FIBROLIV died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FIBROLIV | 5.7 [4.11, 7.91] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 263 out of 545 males with FIBROLIV died.
Mortality risk
Mortality risk for people of age
years, who have FIBROLIV.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.386% | 1.014% |
| 5 | 2.546% | 5.439% |
| 10 | 6.983% | 14.34% |
| 15 | 12.573% | 25.688% |
| 20 | 21.768% | 40.077% |
Relationships between endpoints
↥Index endpoint: FIBROLIV – Fibrosis of liver
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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