No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
459 |
4. Check minimum number of eventsNone |
459 |
5. Include endpointsNone |
459 |
6. Filter based on genotype QC (FinnGen only) |
443 |
Control definitions (FinnGen only)
- Control exclude
- H7_LIDLACRIMALORBIT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H02
- Name in latin
- Lagophthalmus
Similar endpoints
↥List of similar endpoints to
Lagophthalmos
based on the number of shared cases.
Similar with more cases:
- Other disorders of eyelid
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3022 | 1641 | 1356 |
| Only index persons | 2486 | 1397 | 1089 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 65.73 | 66.16 | 65.28 |
| Only index persons | 65.12 | 65.30 | 64.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 443 | 247 | 196 |
| Unadjusted period prevalence (%) | 0.09 | 0.09 | 0.09 |
| Median age at first event (years) | 65.56 | 63.21 | 68.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 459
- Matched controls
- 4590
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G51.0
ICD-10 Finland
Bell palsy
79.4
307.7
180
37
H02.2
ICD-10 Finland
Lagophthalmos
+∞
307.7
443
*
H04.10
ICD-10 Finland
Dry eye syndrome
14.5
127.1
131
123
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
11.6
112.5
384
1404
H02.1
ICD-10 Finland
Ectropion of eyelid
1354.7
112.5
105
*
CBK11
NOMESCO Finland
Operation for lagophtalmus with implant
+∞
105.4
97
*
H02.3
ICD-10 Finland
Blepharochalasis
179.7
97.5
99
7
D33.30
ICD-10 Finland
Acoustic neuroma
52.2
81.0
47
10
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
+∞
80.6
75
*
CBH25
NOMESCO Finland
Tarsorrhaphy
+∞
80.6
75
*
H16.0
ICD-10 Finland
Corneal ulcer
11.8
79.5
89
92
CBN30
NOMESCO Finland
Shortening of canthal ligament
+∞
75.1
70
*
H02.4
ICD-10 Finland
Ptosis of eyelid
128.1
62.7
66
6
CBF10
NOMESCO Finland
Shortening of canthal ligaments and tarsal plate for ectropion
+∞
41.3
39
*
CBJ50
NOMESCO Finland
Operation for ptosis of eyebrow
409.9
38.6
38
*
CBN99
NOMESCO Finland
Other operation on eyelid for malposition
+∞
37.0
35
*
CBB10
NOMESCO Finland
Excision of redundant skin of eyelid
386.2
36.5
36
*
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
6.3
35.1
64
115
WX002
NOMESCO Finland
Sedation and analgesia
3.6
34.2
158
590
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.4
33.1
97
263
CBB11
NOMESCO Finland
Resection of lax skin in upper eyelid
346.6
32.3
32
*
CBH30
NOMESCO Finland
Tarsorraphy
+∞
30.6
29
*
Z3229
NOMESCO Finland
Other healthcare associate professional
4.6
29.7
79
198
XCK10
NOMESCO Finland
Photography of fundus of eye
4.2
29.1
89
248
ZZC00
NOMESCO Finland
Graft of fascia
310.7
29.1
29
*
CBB20
NOMESCO Finland
Correction of lax skin of eyelid and resection of herniated fat
+∞
28.4
27
*
CBF99
NOMESCO Finland
Other operation for ectropion
+∞
27.4
26
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.5
26.6
73
187
CBD99
NOMESCO Finland
Other plastic reconstruction of eyelid
+∞
26.3
25
*
QAJ10
NOMESCO Finland
Browlift
+∞
26.3
25
*
WX110
NOMESCO Finland
Infiltration anesthesia
3.3
25.4
361
2424
QAE40
NOMESCO Finland
Repair of anomaly or lesion after disease of skin of head or neck
61.7
25.3
29
5
ZXA05
NOMESCO Finland
Left side
2.8
24.5
174
810
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
7.4
24.1
36
52
TQW40
NOMESCO Finland
Remowal of suture of skin
4.2
22.9
66
175
9560/0-C72.4
ICD-O-3
Schwannoma, NOS, of acoustic nerve
126.3
22.8
24
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.1
22.3
120
477
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.5
22.0
58
143
ZXA10
NOMESCO Finland
Bilateral
2.9
21.8
130
547
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
29.7
21.2
28
10
ZXD10
NOMESCO Finland
Scheduled procedure
2.5
20.7
220
1228
F29
ICPC
Eye symptom/complaint other
3.7
20.2
71
216
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
37.6
20.0
25
7
H01.0
ICD-10 Finland
Blepharitis
5.9
19.9
37
67
QAJ20
NOMESCO Finland
Subperiosteal facelift
+∞
19.9
19
*
QAJ30
NOMESCO Finland
Other facelift
77.0
19.9
22
*
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
77.0
19.9
22
*
E85.80
ICD-10 Finland
Meretoja sick
208.6
19.7
20
*
S18
ICPC
Laceration/cut
2.5
19.6
259
1585
CBH10
NOMESCO Finland
Plactic repair of canthus
+∞
18.9
18
*
ELB50
NOMESCO Finland
Total parotidectomy
104.4
18.7
20
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.3
18.3
76
257
CBG00
NOMESCO Finland
Epilation of cilia by electrolysis
186.9
17.6
18
*
CBB30
NOMESCO Finland
Excision of lesion of eyelid
6.5
17.4
29
47
TCC10
NOMESCO Finland
Probing of lacrimal canaliculus/duct
93.5
16.7
18
*
H19.8*E85.80
ICD-10 Finland
Reticular keratitis in Meretoja's patients
176.1
16.6
17
*
R4120
NOMESCO Finland
Occupational therapy
3.9
16.4
51
142
ZXA00
NOMESCO Finland
Right side
2.4
16.2
164
875
AA1AD
NOMESCO Finland
CT of head and brain
2.3
16.1
169
916
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
16.0
151
781
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
34.7
15.9
20
6
CBN50
NOMESCO Finland
Excision of tarsus and skin
+∞
15.7
15
*
CB9S4
NOMESCO Finland
Photography of eyelids and eyebrows
88.2
15.7
17
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
13.0
15.6
27
22
H53.2
ICD-10 Finland
Diplopia
5.5
15.5
31
60
ZXE00
NOMESCO Finland
One hour or less
2.2
15.5
207
1235
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
16.8
15.4
24
15
CG2S4
NOMESCO Finland
Photography of cornea
24.4
15.2
21
9
DE2CG
NOMESCO Finland
Acoustic channel extensive MRI examination with high intensity magnet
14.8
14.7
24
17
CBF20
NOMESCO Finland
Resection of part of tarsus for ectropion
+∞
14.7
14
*
D33.3
ICD-10 Finland
Benign neoplasm: Cranial nerves
+∞
14.7
14
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.6
14.5
99
438
H16.9
ICD-10 Finland
Keratitis, unspecified
14.0
14.4
24
18
WF003
NOMESCO Finland
Adjuvant radiotherapy
4.8
14.2
33
73
R4110
NOMESCO Finland
Physiotherapy
2.2
14.0
154
843
ZXE30
NOMESCO Finland
More than five and less than seven hours
4.4
13.7
36
88
CBG99
NOMESCO Finland
Other operation for trichiasis
+∞
13.6
13
*
CBJ40
NOMESCO Finland
Resection of levator muscle of eyelid
+∞
13.6
13
*
CBK99
NOMESCO Finland
Other operation for retraction of eyelid
+∞
13.6
13
*
CBB50
NOMESCO Finland
Excision of lesion of eyelid and reconstruction using graft or flap
41.4
13.2
16
*
S01AA01
ATC
chloramphenicol; ophthalmic
3.9
13.1
40
110
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
5.3
13.1
27
54
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.1
12.9
207
1301
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
51.5
12.9
15
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.6
12.9
88
388
R4190
NOMESCO Finland
Nutritional therapy
5.3
12.8
26
51
D33.39
ICD-10 Finland
Benign tumor of the cranial nerves UNS
+∞
12.6
12
*
3742A
ICD-9 Finland
Other disorders of eyelids, Lagophthalmos
+∞
12.6
12
*
AAH50
NOMESCO Finland
Cranial nerve anastomosis
+∞
12.6
12
*
CBH40
NOMESCO Finland
Division of tarsorrhaphy
+∞
12.6
12
*
CBB21
NOMESCO Finland
Correction of lax skin and resection of herniated fat in upper eyelid
+∞
12.6
12
*
Z3226
NOMESCO Finland
Physiotherapist
2.4
12.5
106
516
S01XA18
ATC
ciclosporin; ophthalmic
133.5
12.5
13
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
3.5
12.2
43
130
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
3.9
12.1
36
97
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.5
12.1
88
400
ZXE20
NOMESCO Finland
More than three and less than five hours
2.5
11.9
86
389
Z3231
NOMESCO Finland
Registered nurse
2.1
11.7
149
853
CD2S4
NOMESCO Finland
Photography of eye
19.6
11.7
17
9
H04.2
ICD-10 Finland
Epiphora
66.7
11.7
13
*
CBW99
NOMESCO Finland
Other operation on eyelid
66.7
11.7
13
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
11.6
190
1192
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
5.2
11.6
24
48
CBN20
NOMESCO Finland
Shortening of eyelid retractors
+∞
11.5
11
*
TCB10
NOMESCO Finland
Simple epilation of cilia
+∞
11.5
11
*
H02.5
ICD-10 Finland
Other disorders affecting eyelid function
+∞
11.5
11
*
CBC10
NOMESCO Finland
Removal of foreign body from eyelid
123.0
11.5
12
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
13.2
11.2
19
15
WZC00
NOMESCO Finland
Treatment plan or consultation
2.0
11.2
179
1111
CG2T4
NOMESCO Finland
Topography assessment of cornea
12.3
10.9
19
16
R4130
NOMESCO Finland
Speech therapy
5.5
10.7
21
40
R13
ICD-10 Finland
Dysphagia
3.0
10.6
48
170
ZZF00
NOMESCO Finland
Graft of adipose tissue
14.7
10.6
17
12
J01DB01
ATC
cefalexin; oral
2.3
10.5
383
3140
AAE32
NOMESCO Finland
Translabyrinthine excision acoustic neurinome
112.5
10.5
11
*
TCC30
NOMESCO Finland
Intubation of lacrimal canaliculus/duct
112.5
10.5
11
*
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
12.4
10.4
18
15
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
3.3
10.3
40
129
ZXD20
NOMESCO Finland
Day surgery
2.5
10.3
74
333
WX402
NOMESCO Finland
General anaesthesia
2.2
10.1
101
524
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
17.2
9.9
15
9
XCK00
NOMESCO Finland
Perimetry
3.1
9.9
42
143
H57.1
ICD-10 Finland
Ocular pain
4.7
9.9
23
51
CBD10
NOMESCO Finland
Plastic reconstruction of eyelid using graft or flap
56.2
9.7
11
*
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.6
9.6
33
98
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
9.4
9.6
19
21
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.3
9.6
83
405
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
12.7
9.4
16
13
CBN00
NOMESCO Finland
Eversion suture of eyelid
+∞
9.4
9
*
2251A
ICD-9 Finland
Benign neoplasm of brain and other parts of nervous system, Cranial nerves
+∞
9.4
9
*
S01AD03
ATC
aciclovir; ophthalmic
4.7
9.4
22
49
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
4.0
9.4
27
71
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
3.5
9.4
32
95
ZZA00
NOMESCO Finland
Split skin graft
4.1
9.3
26
67
H00.1
ICD-10 Finland
Chalazion
7.3
9.1
21
30
Z2221
NOMESCO Finland
Medical doctor
1.9
8.8
133
799
C07.70
ICD-10 Finland
Malignant tumor of the superficial part of the parotid gland
51.0
8.7
10
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
8.6
81
409
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
20.5
8.5
12
6
CBB00
NOMESCO Finland
Excision of chalazion
91.7
8.4
9
*
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
91.7
8.4
9
*
A28
ICPC
Limited function/disability NOS
2.0
8.4
104
582
CBG20
NOMESCO Finland
Plastic repair of margin of eyelid for trichiasis
+∞
8.4
8
*
CCA20
NOMESCO Finland
Incision of lacrimal punctum or canaliculus
+∞
8.4
8
*
TQA05
NOMESCO Finland
Puncture of skin of head or neck
+∞
8.4
8
*
CBG10
NOMESCO Finland
Cryotherapy for trichiasis
+∞
8.4
8
*
QAJ15
NOMESCO Finland
Browlift using video-endoscope
+∞
8.4
8
*
TCC40
NOMESCO Finland
Closure of lacrimal canaliculus with plug
+∞
8.4
8
*
CBJ30
NOMESCO Finland
Plastic repair of levator aponeurosis of eyelid
+∞
8.4
8
*
CBK10
NOMESCO Finland
Operation for lagophtalmus
+∞
8.4
8
*
H05.2
ICD-10 Finland
Exophthalmic conditions
+∞
8.4
8
*
AA1BD
NOMESCO Finland
Extensive CT of head and brain
4.2
8.4
22
54
SPAT1153
SPAT
Removal of sutures
1.8
8.3
165
1078
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
14.8
8.2
13
9
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
8.2
102
572
L28
ICPC
Limited function/disability (L)
2.0
8.1
104
588
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.3
7.9
66
316
C44.11
ICD-10 Finland
Basocellular carcinoma of the skin of the eyelids including the corner of the eye
8.7
7.9
16
19
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
11.1
7.8
14
13
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.4
7.7
58
265
SPAT1231
SPAT
Assessment of adjustments needed in living environment
4.6
7.7
18
40
U13
ICPC
Bladder symptom/complaint other
3.7
7.7
24
67
DM1BD
NOMESCO Finland
Extensive CT of paranasal sinuses and face area
18.7
7.6
11
6
X58
ICD-10 Finland
Exposure to other specified factors
2.2
7.6
69
342
CAC10
NOMESCO Finland
Reconstruction of orbital wall using bone graft or plate
25.5
7.6
10
*
N03AX16
ATC
[U] pregabalin
1.9
7.6
115
687
CBA10
NOMESCO Finland
Biopsy of eyelid
10.3
7.6
14
14
GBB00
NOMESCO Finland
Tracheostomy
10.3
7.6
14
14
N02BE01
ATC
paracetamol; systemic, rectal
2.4
7.5
414
3642
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.2
7.4
67
331
QAE30
NOMESCO Finland
Excision and repair of surgical scar in head or neck
81.4
7.4
8
*
S01EA05
ATC
brimonidine; ophthalmic
4.0
7.3
21
55
QAJ35
NOMESCO Finland
Other correction of loose or redundant skin of head or neck
+∞
7.3
7
*
9560/0-C72.5
ICD-O-3
Schwannoma, NOS, of cranial nerve, NOS
+∞
7.3
7
*
H02.8
ICD-10 Finland
Other specified disorders of eyelid
+∞
7.3
7
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
7.3
7
*
EKC20
NOMESCO Finland
Plastic repair of cheek
+∞
7.3
7
*
D33.37
ICD-10 Finland
Another benign tumor of the cranial nerves
+∞
7.3
7
*
CBE20
NOMESCO Finland
Shortening of eyelid retractors for entropion
+∞
7.3
7
*
H16.4
ICD-10 Finland
Corneal neovascularization
+∞
7.3
7
*
37813
ICD-8 Finland
Other diseases of eye, Lagophthalmus
+∞
7.3
7
*
CBN40
NOMESCO Finland
Excision of tarsus
+∞
7.3
7
*
CBH99
NOMESCO Finland
Other operation on canthus
+∞
7.3
7
*
ZZR00
NOMESCO Finland
Flap of skin
4.2
7.1
19
47
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
12.3
7.1
12
10
R50.9
ICD-10 Finland
Fever, unspecified
2.1
7.1
76
402
SAA04
NOMESCO Finland
Special examination of mouth
3.0
7.0
30
103
K02.1
ICD-10 Finland
Caries of dentine
1.7
7.0
243
1837
TCG10
NOMESCO Finland
Removal of sutures from cornea
14.0
6.9
11
8
N30.0
ICD-10 Finland
Acute cystitis
2.0
6.6
80
441
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.9
6.6
88
502
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
8.9
6.6
13
15
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
6.5
65
334
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.5
6.5
41
173
Z71.8
ICD-10 Finland
Other specified counselling
1.7
6.5
136
892
RD210, ,
NOMESCO Finland
7.6
6.5
14
19
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.7
6.4
35
137
ZZK00
NOMESCO Finland
Graft of nerve
70.8
6.4
7
*
H17.8
ICD-10 Finland
Other corneal scars and opacities
70.8
6.4
7
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
1.7
6.4
170
1190
Z96.1
ICD-10 Finland
Presence of intraocular lens
1.9
6.4
81
455
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.6
6.3
37
151
EKC99
NOMESCO Finland
Other reconstructive operations on cheek
+∞
6.3
6
*
CBJ99
NOMESCO Finland
Other operation for ptosis
+∞
6.3
6
*
D32.06
ICD-10 Finland
Benign tumor of the meninges os petrosum or clivus area
+∞
6.3
6
*
AAE34
NOMESCO Finland
Other operations on acoustical nerv
+∞
6.3
6
*
CBF30
NOMESCO Finland
Excision of tarsus and skin for ectropion
+∞
6.3
6
*
CBN60
NOMESCO Finland
Excision of scar of eyelid and plastic reconstruction
+∞
6.3
6
*
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
7.2
6.3
14
20
G51.8
ICD-10 Finland
Other disorders of facial nerve
27.1
6.2
8
*
QB9S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in torso, unspecified
27.1
6.2
8
*
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
2.7
6.2
33
128
SAA01
NOMESCO Finland
Simple examination of mouth
1.7
6.2
299
2428
S01EE05
ATC
tafluprost; ophthalmic
3.1
6.2
25
83
N02AX02
ATC
tramadol; systemic, rectal
1.6
6.1
202
1491
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.4
6.1
21
63
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
3.1
6.1
25
84
R33
ICD-10 Finland
Retention of urine
2.2
6.0
49
232
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.6
6.0
230
1757
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
156
882
2.16
12.88
2.5
2.4
—
—
—
0
0
258
1788
2.01
12.00
8.3
5.5
1.21
1.21
mmol/l
0.16
237
1626
245
1679
1.98
11.64
6.1
4.4
35.01
35.19
g/l
0.21
228
1561
272
1945
1.98
11.29
9.8
6.4
1.21
1.21
mmol/l
0.13
241
1649
177
1093
2.01
11.25
4.4
3.1
0.19
0.41
e6/l
2.20
138
829
29
70
4.35
11.24
1.7
1.2
188.86
15.91
e6/l
0.74
21
56
29
70
4.35
11.24
1.7
1.3
740.67
164.98
e6/l
0.54
21
59
141
831
2.01
10.02
3.4
2.5
4.25
4.73
e6/l
0.30
123
759
209
1410
1.89
9.90
4.6
3.1
—
—
—
0
0
118
658
2.07
9.73
3.8
2.8
1.14
1.07
e6/l
0.11
65
379
198
1337
1.85
9.16
3.6
3.6
2.34
2.35
mmol/l
0.28
174
1181
241
1733
1.82
9.04
7.0
5.3
58.64
57.85
%
0.43
229
1628
282
2141
1.82
8.70
10.9
9.0
4.44
4.20
e9/l
0.39
246
1903
110
627
1.99
8.42
3.3
3.0
0.82
0.81
mmol/l
0.26
104
589
69
335
2.25
8.01
2.0
1.9
389.86
383.86
nmol/l
0.09
63
311
239
1761
1.75
7.85
7.4
5.5
26.08
27.00
%
0.51
227
1651
125
764
1.87
7.70
2.7
3.1
2.46
2.45
mmol/l
0.18
109
683
211
1512
1.73
7.57
2.8
2.2
79.09
77.93
nmol/l
0.24
190
1332
418
3695
2.47
7.40
23.6
15.0
26.65
24.65
mg/l
0.60
358
2957
111
661
1.90
7.38
2.0
1.8
—
—
—
0
0
89
493
2.00
7.31
8.7
4.8
1.07
1.03
mmol/l
0.55
84
449
84
458
2.02
7.21
2.0
1.8
—
—
—
0
0
14
16
8.99
7.09
1.0
1.4
—
—
—
0
0
14
16
8.99
7.09
2.1
1.3
—
—
—
0
0
104
617
1.89
6.96
3.7
3.0
2.97
2.68
e6/l
0.10
51
340
83
457
2.00
6.92
2.0
1.7
—
—
—
0
0
248
1904
1.66
6.55
13.9
16.3
1.25
1.30
inr
0.29
57
556
232
1752
1.66
6.53
3.0
2.6
—
—
—
0
0
148
995
1.72
6.47
1.9
1.6
20.66
20.79
nmol/l
0.04
129
831
283
2264
1.65
6.22
6.3
4.4
6.65
6.78
mmol/l
0.63
266
2119
85
489
1.91
6.21
7.4
5.9
104.05
104.27
mmol/l
0.14
85
489
15
27
5.71
5.73
1.1
1.3
—
—
—
0
0
49
242
2.15
5.44
1.8
1.7
—
—
—
0
0
213
1624
1.58
5.44
2.6
2.0
90.90
94.87
pmol/l
0.66
105
835
89
547
1.78
5.22
3.4
2.3
21.25
21.40
%
0.03
76
463
384
3395
1.80
5.18
5.7
4.7
1.80
1.98
mu/l
2.33
352
3045
62
343
1.93
5.06
3.1
2.8
66.37
66.55
g/l
0.06
55
315
12
20
6.13
4.94
1.9
1.5
—
—
—
0
0
255
2065
1.53
4.73
7.1
6.2
10.08
11.31
umol/l
1.71
246
1954
327
2801
1.58
4.67
4.6
3.9
14.99
14.97
pmol/l
0.06
293
2495
342
2963
1.61
4.62
9.9
7.5
83.09
79.51
u/l
0.66
330
2765
15
36
4.27
4.55
2.1
2.9
—
—
—
0
0
98
644
1.66
4.49
3.4
2.3
11.52
12.62
umol/l
0.66
90
596
91
588
1.68
4.44
3.3
2.3
2.20
2.33
g/l
1.24
84
543
241
1956
1.49
4.25
2.7
2.6
—
—
—
0
0
74
464
1.71
4.02
8.2
6.4
5.21
5.05
kpa
0.80
69
448
10
18
5.65
3.99
1.1
1.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
10
18
5.65
3.99
1.3
1.2
—
—
—
0
0
74
465
1.71
3.99
8.2
6.3
14.30
12.06
kpa
2.10
69
450
62
376
1.75
3.79
4.1
3.5
2.18
2.16
mmol/l
0.02
53
306
11
24
4.67
3.76
1.3
1.2
3.21
1.84
mmol/l
0.76
11
24
321
2795
1.49
3.75
5.2
4.1
16.14
13.41
mm/h
2.16
297
2566
137
1013
1.50
3.72
3.0
2.1
3.03
3.13
mg/l
0.17
118
868
72
464
1.65
3.53
8.2
6.4
2.01
1.32
mmol/l
0.96
55
375
385
3505
1.61
3.49
21.2
14.3
76.98
76.92
ml/min/173m2
0.02
332
2897
159
1229
1.45
3.40
2.6
2.3
52.49
124.04
u/l
0.56
146
1127
59
364
1.71
3.40
2.8
2.5
5.45
5.90
ug/l
0.11
50
323
430
4046
1.99
3.31
34.0
22.4
250.43
245.68
e9/l
0.70
423
3935
419
3911
1.82
3.30
14.3
10.7
24.80
25.17
u/l
0.20
402
3750
430
4047
1.99
3.29
33.9
22.4
39.17
39.81
%
1.43
413
3772
430
4049
1.98
3.26
34.1
22.4
4.36
4.44
e12/l
2.73
424
3926
109
788
1.50
3.25
1.7
1.8
1112.60
1238.70
nmol/l
0.72
76
585
9
19
4.81
3.25
1.2
2.2
—
—
—
0
0
22
98
2.31
3.18
3.3
2.1
11.31
13.51
mg/l
0.54
22
91
70
463
1.60
3.10
3.8
4.1
231.45
247.65
u/l
0.74
64
437
35
190
1.91
3.06
1.5
2.0
1.67
1.46
g/l
0.53
30
167
8
16
5.07
3.06
1.0
1.1
—
—
—
0
0
21
94
2.29
3.01
1.3
1.2
—
—
—
0
0
47
284
1.73
2.93
1.5
1.6
—
—
—
0
0
10
27
3.76
2.89
1.2
1.1
—
—
—
0
0
54
342
1.66
2.84
1.6
1.7
1.56
1.58
%
0.04
42
296
20
90
2.28
2.84
1.4
1.2
—
2.45
—
0
8
6
10
6.06
2.70
1.2
1.3
—
—
—
0
0
72
497
1.53
2.66
7.9
8.2
—
—
—
0
0
62
414
1.58
2.65
3.2
2.4
7.70
8.52
umol/l
0.14
57
364
190
1569
1.36
2.63
4.0
2.7
119.83
135.19
ug/l
0.50
175
1426
106
795
1.43
2.59
1.6
1.6
1.22
1.26
mg/l
0.08
78
630
11
36
3.11
2.58
1.2
1.1
—
—
—
0
0
5
7
7.21
2.55
1.0
1.0
—
—
—
0
0
6
11
5.51
2.55
1.0
1.0
—
—
—
0
0
157
1263
1.37
2.55
2.5
3.2
2125.97
1471.25
ng/l
0.69
137
1091
46
289
1.66
2.51
2.9
2.5
46.48
63.64
ml/min/173m2
2.23
21
123
65
445
1.54
2.49
3.9
4.3
3.07
32.63
ug/l
1.03
52
376
16
70
2.33
2.44
2.6
1.5
4.67
4.19
iu/l
—
7
20
218
1858
1.33
2.38
6.5
5.1
0.00
0.00
estimate
0.50
32
370
8
22
3.68
2.37
1.4
1.0
264.25
246.14
mg/l
—
8
22
7
17
4.16
2.37
1.0
1.3
—
—
—
0
0
28
156
1.85
2.31
2.1
2.1
—
—
—
0
0
6
13
4.66
2.28
1.0
1.0
—
—
—
0
0
26
143
1.87
2.24
2.0
2.2
10.38
10.34
g/l
0.01
21
129
5
9
5.60
2.22
1.0
1.3
—
—
—
0
0
22
115
1.96
2.19
1.7
1.5
—
—
—
0
0
218
1875
1.31
2.17
5.0
3.9
0.03
0.00
estimate
0.49
32
359
17
81
2.14
2.15
1.6
1.2
—
—
—
0
0
98
750
1.39
2.12
5.3
3.6
556.16
219.11
ng/l
0.46
85
609
24
131
1.88
2.12
1.5
1.2
—
—
—
0
0
5
10
5.04
2.07
1.2
1.6
—
—
—
0
0
38
240
1.64
2.06
1.6
1.5
—
—
—
0
0
24
133
1.85
2.03
3.2
2.8
—
—
—
0
0
10
38
2.67
2.01
1.2
1.1
—
—
—
0
0
214
1850
1.29
2.00
5.0
3.9
0.00
0.01
estimate
0.74
36
404
5
11
4.58
1.94
1.2
1.2
—
—
—
0
0
5
11
4.58
1.94
1.0
1.3
—
—
—
0
0
49
335
1.52
1.92
3.6
2.3
32.52
32.76
u/l
0.02
44
283
7
22
3.21
1.88
1.6
1.6
—
—
—
0
0
7
22
3.21
1.88
1.6
1.6
—
—
—
0
0
8
28
2.89
1.87
1.3
1.1
—
—
—
0
0
184
1573
1.28
1.84
3.8
3.9
38.99
61.38
ng/l
0.48
147
1183
384
3618
1.38
1.76
5.5
4.8
5.93
6.01
mmol/l
0.77
351
3232
141
1171
1.29
1.75
3.3
3.2
38.81
32.18
u/l
1.03
134
1104
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
23
134
1.75
1.69
2.8
2.4
0.30
0.38
u/ml
0.79
16
75
26
158
1.68
1.66
3.8
4.1
26.31
25.16
mmol/l
0.35
21
150
7
25
2.83
1.65
5.3
1.8
—
—
—
0
0
7
25
2.83
1.65
1.1
1.1
—
—
—
0
0
20
113
1.80
1.63
1.2
1.2
—
—
—
0
0
5
14
3.60
1.62
1.0
1.1
—
—
—
0
0
8
32
2.53
1.60
1.1
1.5
—
—
—
0
0
26
160
1.66
1.59
1.7
1.7
—
—
—
0
0
20
114
1.79
1.59
1.2
1.2
—
—
—
0
0
14
71
2.00
1.55
1.3
1.2
—
—
—
0
0
14
71
2.00
1.55
1.3
1.2
—
—
—
0
0
20
116
1.76
1.51
1.5
1.6
—
—
—
0
0
15
79
1.93
1.51
2.0
3.6
61.01
417.66
u/ml
0.61
15
74
6
21
2.88
1.51
1.3
1.0
—
—
—
0
0
9
37
2.46
1.48
2.2
1.5
—
—
—
0
0
7
28
2.52
1.45
1.3
1.3
—
—
—
0
0
7
28
2.52
1.45
1.3
1.3
—
—
—
0
0
14
73
1.95
1.45
1.4
1.2
—
—
—
0
0
93
749
1.30
1.44
1.3
1.2
1.09
1.66
u/ml
0.46
26
200
5
16
3.15
1.44
2.8
1.5
23.60
29.50
umol/l
—
5
16
9
41
2.22
1.37
1.2
1.7
—
—
—
0
0
19
112
1.73
1.37
1.3
1.3
—
—
—
0
0
6
23
2.63
1.37
1.3
1.2
—
—
—
0
0
6
23
2.63
1.37
1.3
1.2
—
—
—
0
0
5
17
2.96
1.36
1.2
1.9
—
—
—
0
0
5
17
2.96
1.36
1.2
1.9
—
—
—
0
0
11
54
2.06
1.34
1.3
1.2
—
—
—
0
0
15
83
1.83
1.33
2.1
2.3
126.63
125.93
g/l
—
8
62
35
243
1.48
1.32
1.9
2.4
12.03
12.61
nmol/l
0.13
29
211
6
24
2.52
1.30
1.0
1.2
—
—
—
0
0
5
18
2.80
1.29
1.2
1.8
—
—
—
0
0
9
44
2.07
1.27
1.2
1.7
—
—
—
0
0
35
247
1.45
1.23
3.8
3.6
3.10
1.99
mmol/l
0.48
25
186
386
3687
1.30
1.23
5.8
5.2
2.56
2.70
mmol/l
1.98
352
3343
5
19
2.65
1.22
1.0
1.2
—
—
—
0
0
365
3465
1.26
1.21
6.8
6.1
41.03
40.42
mmol/mol
0.54
327
3179
141
1219
1.23
1.20
4.0
3.1
6.76
7.19
mmol/l
0.71
117
999
6
26
2.32
1.19
1.0
1.0
—
—
—
0
0
11
57
1.95
1.18
1.3
1.3
—
—
—
0
0
90
743
1.26
1.16
3.6
3.1
1.09
0.79
ug/l
1.30
61
506
5
20
2.52
1.15
1.4
1.6
—
—
—
0
0
5
20
2.52
1.15
3.2
3.2
34.00
32.93
umol/l
—
5
15
14
80
1.77
1.14
1.3
1.4
—
—
—
0
0
14
80
1.77
1.14
2.0
1.9
4.17
4.37
mmol/24h
0.08
14
69
5
21
2.40
1.09
1.4
1.6
—
—
—
0
0
30
213
1.44
1.05
1.8
1.8
—
—
—
0
0
17
106
1.63
1.04
2.1
2.2
—
—
—
0
0
5
22
2.29
1.03
2.4
4.1
77.60
135.14
nmol/l
—
5
22
5
22
2.29
1.03
1.2
1.7
—
—
—
0
0
5
22
2.29
1.03
1.2
1.7
—
—
—
0
0
5
22
2.29
1.03
1.2
1.2
—
—
—
0
0
12
68
1.79
1.01
1.3
1.6
—
—
—
0
0
16
100
1.62
0.98
1.4
1.6
12529.18
23126.62
e6/l
0.53
11
73
16
100
1.62
0.98
2.0
1.5
—
—
—
0
0
21
142
1.50
0.94
1.0
1.0
—
—
—
0
0
13
78
1.69
0.92
2.4
1.7
313.00
293.67
mu/l
0.13
13
72
8
44
1.83
0.86
1.1
1.1
—
—
—
0
0
17
112
1.54
0.86
1.5
1.5
276.92
268.74
ug/g
0.06
12
61
31
231
1.37
0.85
1.9
1.8
—
—
—
0
0
14
88
1.61
0.85
1.4
1.6
—
—
—
0
0
120
1057
1.18
0.83
4.4
4.7
23.35
21.35
%
0.71
60
538
95
821
1.20
0.81
5.7
4.2
1.02
1.02
kg/l
—
8
116
24
173
1.41
0.80
1.3
1.3
—
—
—
0
0
6
33
1.83
0.79
1.5
1.6
—
—
—
0
0
11
67
1.66
0.75
1.3
1.5
—
—
—
0
0
9
54
1.68
0.75
1.3
1.6
—
—
—
0
0
112
990
1.17
0.75
3.5
2.7
365.39
8152.57
umol/l
4.98
100
855
14
92
1.54
0.73
1.4
1.6
—
—
—
0
0
5
25
2.01
0.73
1.2
1.2
—
—
—
0
0
5
25
2.01
0.73
1.2
1.2
—
—
—
0
0
7
39
1.81
0.72
1.4
1.6
—
—
—
0
0
7
39
1.81
0.72
1.4
1.6
—
—
—
0
0
7
39
1.81
0.72
1.4
1.6
—
—
—
0
0
9
56
1.62
0.72
1.3
1.5
—
—
—
0
0
10
60
1.68
0.72
1.3
1.5
—
—
—
0
0
5
26
1.93
0.71
1.2
1.2
—
—
—
0
0
5
26
1.93
0.71
1.2
1.2
—
—
—
0
0
5
26
1.93
0.71
1.2
1.2
—
—
—
0
0
147
1334
1.15
0.69
5.7
5.3
3.59
3.71
ug/l
0.04
126
1167
372
3598
1.18
0.69
5.2
4.6
4.47
4.60
mmol/l
1.57
340
3279
5
27
1.86
0.68
1.4
1.6
—
—
—
0
0
139
1258
1.15
0.68
4.8
3.8
18.22
8.95
mg/mmol
0.76
101
781
12
78
1.55
0.66
1.1
1.6
—
—
—
0
0
245
2321
1.12
0.57
3.6
3.0
51.02
51.49
u/l
0.04
224
2125
59
509
1.18
0.54
5.6
4.7
31.61
32.64
%
0.31
38
327
6
41
1.47
0.50
1.5
1.6
—
—
—
0
0
19
146
1.31
0.47
1.7
1.6
—
—
—
0
0
32
265
1.22
0.46
3.3
3.2
122.31
125.99
g/l
0.37
32
259
49
424
1.17
0.45
4.2
3.4
—
—
—
0
0
5
32
1.57
0.42
2.0
2.0
—
—
—
0
0
13
96
1.36
0.42
1.4
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
184.37
—
0
15
8
59
1.36
0.41
1.4
1.6
—
—
—
0
0
8
59
1.36
0.41
1.4
1.6
—
—
—
0
0
5
35
1.43
0.39
1.4
1.1
—
—
—
0
0
25
206
1.23
0.38
1.5
1.1
105.40
104.81
iu/ml
—
10
76
12
89
1.36
0.38
1.8
2.6
15.70
15.66
%
—
5
43
19
235
0.80
0.38
2.0
1.7
—
—
—
0
0
6
42
1.43
0.35
2.3
2.8
27.03
69.03
u/ml
—
6
42
6
42
1.43
0.35
3.5
2.3
—
—
—
0
0
10
73
1.38
0.35
1.2
1.3
—
—
—
0
0
365
3577
1.10
0.33
5.1
4.6
1.41
1.47
mmol/l
2.13
334
3235
11
83
1.33
0.32
1.1
1.9
43.55
42.66
nmol/l
0.04
11
77
67
614
1.11
0.29
1.3
1.3
43.87
36.98
iu/ml
0.12
20
208
7
57
1.23
0.29
1.6
1.5
—
—
—
0
0
9
75
1.20
0.25
1.1
1.1
—
—
—
0
0
94
884
1.08
0.24
1.7
1.8
507.86
7994828.79
pmol/l
0.50
72
713
110
1042
1.07
0.24
6.0
4.2
0.06
0.00
estimate
0.46
31
360
12
97
1.24
0.23
1.5
1.3
—
—
—
0
0
5
39
1.29
0.23
1.6
1.2
—
—
—
0
0
7
94
0.74
0.22
1.0
1.1
—
16.59
—
0
10
46
501
0.91
0.21
1.5
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
352
3466
1.07
0.21
4.7
4.1
1.33
1.28
mmol/l
0.55
316
3119
0
12
0.00
0.21
0.0
5.2
—
220.00
—
0
12
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
6.2
—
—
—
0
0
51
472
1.09
0.20
1.5
1.4
—
—
—
0
0
15
127
1.19
0.20
1.6
1.7
—
124.00
—
0
5
6
50
1.20
0.20
1.0
1.0
—
—
—
0
0
7
58
1.21
0.18
1.3
1.3
—
—
—
0
0
24
214
1.13
0.18
4.5
3.4
24.69
25.00
mmol/l
0.22
24
209
7
60
1.17
0.18
1.3
1.3
—
—
—
0
0
7
60
1.17
0.18
1.3
1.3
—
—
—
0
0
7
60
1.17
0.18
1.3
1.3
—
—
—
0
0
7
60
1.17
0.18
1.3
1.3
—
—
—
0
0
7
61
1.15
0.17
1.3
1.3
—
—
—
0
0
5
70
0.71
0.17
1.4
1.2
79.68
42.40
u/l
—
5
59
8
98
0.81
0.14
1.3
1.4
—
—
—
0
0
62
591
1.06
0.12
1.3
1.2
5.86
10.62
u/ml
0.51
19
227
23
212
1.09
0.10
3.8
3.6
52.30
49.53
%
0.23
23
207
5
48
1.04
0.09
1.8
1.4
—
—
—
0
0
5
60
0.83
0.08
1.2
1.1
—
—
—
0
0
8
76
1.05
0.07
4.6
2.9
59.75
59.76
%
—
8
76
21
224
0.93
0.07
3.7
2.8
0.22
0.26
e6/l
0.19
21
217
9
104
0.86
0.06
1.7
1.6
—
—
—
0
0
99
974
1.02
0.04
1.7
1.6
1.41
1.35
mmol/l
0.31
84
785
148
1467
1.01
0.03
5.4
4.1
—
—
—
0
0
12
118
1.02
0.00
1.7
1.6
2.16
2.38
mg/l
—
7
89
0
8
0.00
-0.00
0.0
2.0
—
1.26
—
0
8
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
108.00
—
0
5
5
49
1.02
-0.00
2.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
8
80
1.00
-0.00
1.5
1.5
—
—
—
0
0
7
75
0.93
-0.00
1.4
1.2
0.58
0.87
nmol/l
—
7
62
Mortality – FinRegistry
↥Association
Association between endpoint H7_LAGOPHTALMOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_LAGOPHTALMOS | 1.358 [1.15, 1.61] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.529 |
During the follow-up period (1.1.1998 — 31.12.2019), 392 out of 1238 females with H7_LAGOPHTALMOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_LAGOPHTALMOS | 1.744 [1.42, 2.14] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 375 out of 944 males with H7_LAGOPHTALMOS died.
Mortality risk
Mortality risk for people of age
years, who have H7_LAGOPHTALMOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.119% | 0.273% |
| 5 | 0.782% | 1.808% |
| 10 | 2.201% | 4.344% |
| 15 | 4.166% | 8.147% |
| 20 | 6.923% | 13.65% |
Relationships between endpoints
↥Index endpoint: H7_LAGOPHTALMOS – Lagophthalmos
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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