No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
415 |
4. Check minimum number of eventsNone |
415 |
5. Include endpointsNone |
415 |
6. Filter based on genotype QC (FinnGen only) |
415 |
Control definitions (FinnGen only)
- Control exclude
- H7_LIDLACRIMALORBIT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H02
- Name in latin
- Lagophthalmus
Similar endpoints
↥List of similar endpoints to
Lagophthalmos
based on the number of shared cases.
Similar with more cases:
- Other disorders of eyelid
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3022 | 1641 | 1356 |
| Only index persons | 2486 | 1397 | 1089 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 65.73 | 66.16 | 65.28 |
| Only index persons | 65.12 | 65.30 | 64.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 415 | 226 | 189 |
| Unadjusted period prevalence (%) | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | 65.12 | 62.81 | 67.87 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 366
- Matched controls
- 3661
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H02.2
ICD-10 Finland
Lagophthalmos
+∞
323.0
351
*
G51.0
ICD-10 Finland
Bell palsy
91.5
134.4
145
26
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
12.0
92.2
303
1045
H02.1
ICD-10 Finland
Ectropion of eyelid
+∞
85.9
79
*
CBK11
NOMESCO Finland
Operation for lagophtalmus with implant
+∞
80.2
74
*
H02.3
ICD-10 Finland
Blepharochalasis
318.3
77.7
76
*
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
+∞
66.7
62
*
CBH25
NOMESCO Finland
Tarsorrhaphy
+∞
64.5
60
*
H04.10
ICD-10 Finland
Dry eye syndrome
17.4
58.1
95
72
CBN30
NOMESCO Finland
Shortening of canthal ligament
+∞
48.0
45
*
H02.4
ICD-10 Finland
Ptosis of eyelid
94.0
45.1
49
6
H16.0
ICD-10 Finland
Corneal ulcer
17.3
44.0
71
50
D33.30
ICD-10 Finland
Acoustic neuroma
65.6
36.0
41
7
CBF10
NOMESCO Finland
Shortening of canthal ligaments and tarsal plate for ectropion
340.3
31.3
31
*
CBJ50
NOMESCO Finland
Operation for ptosis of eyebrow
327.9
30.3
30
*
CBB10
NOMESCO Finland
Excision of redundant skin of eyelid
327.9
30.3
30
*
CBH30
NOMESCO Finland
Tarsorraphy
+∞
28.5
27
*
QAE40
NOMESCO Finland
Repair of anomaly or lesion after disease of skin of head or neck
133.7
23.9
25
*
WX002
NOMESCO Finland
Sedation and analgesia
3.6
22.0
123
455
9560/0-C72.4
ICD-O-3
Schwannoma, NOS, of acoustic nerve
85.4
21.9
24
*
CBN99
NOMESCO Finland
Other operation on eyelid for malposition
233.2
21.8
22
*
ZZC00
NOMESCO Finland
Graft of fascia
233.2
21.8
22
*
WX110
NOMESCO Finland
Local anesthesy
3.1
21.1
277
1825
CBB20
NOMESCO Finland
Correction of lax skin of eyelid and resection of herniated fat
+∞
20.0
19
*
CBB11
NOMESCO Finland
Resection of lax skin in upper eyelid
111.0
19.8
21
*
ZXA05
NOMESCO Finland
Left side
3.0
18.6
139
624
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.1
18.5
80
236
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
55.5
18.1
21
*
CBF99
NOMESCO Finland
Other operation for ectropion
+∞
17.8
17
*
QAJ30
NOMESCO Finland
Other facelift
99.9
17.7
19
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.0
17.4
59
136
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
20.5
17.1
25
13
CG2S4
NOMESCO Finland
Photography of cornea
66.5
16.9
19
*
E85.80
ICD-10 Finland
Meretoja sick
+∞
16.8
16
*
QAJ20
NOMESCO Finland
Subperiosteal facelift
+∞
16.8
16
*
QAJ10
NOMESCO Finland
Browlift
177.7
16.6
17
*
XCK10
NOMESCO Finland
Photography of fundus of eye
4.0
16.2
70
205
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
11.2
16.0
30
29
CBH10
NOMESCO Finland
Plactic repair of canthus
+∞
15.7
15
*
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
166.7
15.6
16
*
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
166.7
15.6
16
*
ZXA10
NOMESCO Finland
Bilateral
3.1
15.4
98
385
D33.3
ICD-10 Finland
Benign neoplasm: Cranial nerves
+∞
14.7
14
*
CBD99
NOMESCO Finland
Other plastic reconstruction of eyelid
+∞
14.7
14
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.2
14.6
84
308
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
17.9
14.5
22
13
TQW40
NOMESCO Finland
Remowal of suture of skin
4.7
14.1
49
116
CB9S4
NOMESCO Finland
Photography of eyelids and eyebrows
55.5
13.9
16
*
H19.8*E85.80
ICD-10 Finland
Reticular keratitis in Meretoja's patients
+∞
13.6
13
*
TCC10
NOMESCO Finland
Probing of lacrimal canaliculus/duct
+∞
13.6
13
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.5
13.0
47
116
ELB50
NOMESCO Finland
Total parotidectomy
72.4
12.7
14
*
AAH50
NOMESCO Finland
Cranial nerve anastomosis
+∞
12.6
12
*
CBN50
NOMESCO Finland
Excision of tarsus and skin
+∞
12.6
12
*
CBF20
NOMESCO Finland
Resection of part of tarsus for ectropion
+∞
12.6
12
*
CBG00
NOMESCO Finland
Epilation of cilia by electrolysis
+∞
12.6
12
*
3742A
ICD-9 Finland
Other disorders of eyelids, Lagophthalmos
+∞
12.6
12
*
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
+∞
12.6
12
*
S01AA01
ATC
chloramphenicol; ophthalmic (antibiotics)
5.3
12.4
38
78
S18
ICPC
Laceration/cut
2.2
12.3
186
1157
ZXA00
NOMESCO Finland
Right side
2.4
12.3
130
680
F29
ICPC
Eye symptom/complaint other
4.2
11.8
45
117
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
13.1
11.8
20
16
CBC10
NOMESCO Finland
Removal of foreign body from eyelid
+∞
11.5
11
*
CBB21
NOMESCO Finland
Correction of lax skin and resection of herniated fat in upper eyelid
+∞
11.5
11
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
11.3
119
616
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.5
11.0
54
174
CG2T4
NOMESCO Finland
Topography assessment of cornea
22.2
10.8
15
7
D33.39
ICD-10 Finland
Benign tumor of the cranial nerves UNS
113.1
10.5
11
*
CBG99
NOMESCO Finland
Other operation for trichiasis
+∞
10.5
10
*
AA1AD
NOMESCO Finland
CT of head and brain
2.3
10.3
120
649
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
41.3
10.0
12
*
CBB30
NOMESCO Finland
Excision of lesion of eyelid
7.7
9.8
22
30
CD2S4
NOMESCO Finland
Photography of eye
30.9
9.5
12
*
CBB50
NOMESCO Finland
Excision of lesion of eyelid and reconstruction using graft or flap
30.9
9.5
12
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.1
9.4
157
980
CBW99
NOMESCO Finland
Other operation on eyelid
+∞
9.4
9
*
CBN20
NOMESCO Finland
Shortening of eyelid retractors
+∞
9.4
9
*
H01.80
ICD-10 Finland
Prolonged inflammation in the edge of the eyelid
+∞
9.4
9
*
CBH40
NOMESCO Finland
Division of tarsorrhaphy
+∞
9.4
9
*
CBK99
NOMESCO Finland
Other operation for retraction of eyelid
+∞
9.4
9
*
H01.0
ICD-10 Finland
Blepharitis
5.6
9.2
26
49
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
16.1
9.1
14
9
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.6
8.9
68
294
H04.2
ICD-10 Finland
Epiphora
51.2
8.7
10
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
9.3
8.6
17
19
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
28.2
8.5
11
*
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
28.2
8.5
11
*
2251A
ICD-9 Finland
Benign neoplasm of brain and other parts of nervous system, Cranial nerves
92.0
8.4
9
*
QAJ15
NOMESCO Finland
Browlift using video-endoscope
+∞
8.4
8
*
TCB10
NOMESCO Finland
Simple epilation of cilia
+∞
8.4
8
*
CBJ40
NOMESCO Finland
Resection of levator muscle of eyelid
+∞
8.4
8
*
CBD10
NOMESCO Finland
Plastic reconstruction of eyelid using graft or flap
+∞
8.4
8
*
N02BE01
ATC
paracetamol; systemic, rectal
2.3
8.1
318
2704
R4120
NOMESCO Finland
Occupational therapy
3.5
7.9
36
110
H16.9
ICD-10 Finland
Keratitis, unspecified
9.7
7.8
15
16
H53.2
ICD-10 Finland
Diplopia
4.6
7.6
25
57
DE2CG
NOMESCO Finland
Acoustic channel extensive MRI examination with high intensity magnet
6.7
7.5
18
28
CAC10
NOMESCO Finland
Reconstruction of orbital wall using bone graft or plate
81.6
7.4
8
*
AAE32
NOMESCO Finland
Translabyrinthine excision acoustic neurinome
81.6
7.4
8
*
SPAT1153
SPAT
Removal of sutures
1.9
7.4
135
855
CBG10
NOMESCO Finland
Cryotherapy for trichiasis
+∞
7.3
7
*
H02.5
ICD-10 Finland
Other disorders affecting eyelid function
+∞
7.3
7
*
CBK10
NOMESCO Finland
Operation for lagophtalmus
+∞
7.3
7
*
CBB00
NOMESCO Finland
Excision of chalazion
+∞
7.3
7
*
CFD10
NOMESCO Finland
Repair of conjunctiva
+∞
7.3
7
*
ZZK00
NOMESCO Finland
Graft of nerve
+∞
7.3
7
*
CBN00
NOMESCO Finland
Eversion suture of eyelid
+∞
7.3
7
*
J01DB01
ATC
cefalexin; oral
2.0
7.1
294
2448
ZZF00
NOMESCO Finland
Graft of adipose tissue
12.3
7.1
12
10
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
3.6
7.0
30
88
TCG10
NOMESCO Finland
Removal of sutures from cornea
14.1
6.9
11
8
SAA04
NOMESCO Finland
Special inverstigation of mouth
3.8
6.9
28
79
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
11.2
6.8
12
11
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
40.8
6.8
8
*
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
3.6
6.7
29
86
DM1BD
NOMESCO Finland
Extensive CT of paranasal sinuses and face area
23.0
6.7
9
*
CBA10
NOMESCO Finland
Biopsy of eyelid
23.0
6.7
9
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
4.3
6.6
23
56
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.3
6.6
61
287
TCC30
NOMESCO Finland
Intubation of lacrimal canaliculus/duct
71.0
6.4
7
*
H16.2
ICD-10 Finland
Keratoconjunctivitis
71.0
6.4
7
*
C07.70
ICD-10 Finland
Malignant tumor of the superficial part of the parotid gland
71.0
6.4
7
*
T90.5
ICD-10 Finland
Sequelae of intracranial injury
18.4
6.3
9
5
H05.2
ICD-10 Finland
Exophthalmic conditions
+∞
6.3
6
*
CBJ30
NOMESCO Finland
Plastic repair of levator aponeurosis of eyelid
+∞
6.3
6
*
H17.8
ICD-10 Finland
Other corneal scars and opacities
+∞
6.3
6
*
TCC40
NOMESCO Finland
Closure of lacrimal canaliculus with plug
+∞
6.3
6
*
CBG20
NOMESCO Finland
Plastic repair of margin of eyelid for trichiasis
+∞
6.3
6
*
QAE30
NOMESCO Finland
Excision and repair of surgical scar in head or neck
+∞
6.3
6
*
37813
ICD-8 Finland
Other diseases of eye, Lagophthalmus
+∞
6.3
6
*
EKC20
NOMESCO Finland
Plastic repair of cheek
+∞
6.3
6
*
CBE20
NOMESCO Finland
Shortening of eyelid retractors for entropion
+∞
6.3
6
*
TQA05
NOMESCO Finland
Puncture of skin of head or neck
+∞
6.3
6
*
CCA20
NOMESCO Finland
Incision of lacrimal punctum or canaliculus
+∞
6.3
6
*
D33.37
ICD-10 Finland
Another benign tumor of the cranial nerves
+∞
6.3
6
*
QAJ35
NOMESCO Finland
Other correction of loose or redundant skin of head or neck
+∞
6.3
6
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
6.3
81
447
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
27
63
4.51
10.93
1.8
1.3
776.9
190.0
e6/l
0.52
20
53
27
63
4.51
10.93
1.7
1.2
137.3
7.4
e6/l
0.53
20
50
13
14
9.55
10.81
2.2
1.2
—
—
—
0
0
138
809
2.06
10.17
2.5
2.4
—
—
—
0
0
13
16
8.36
9.78
1.0
1.4
—
—
—
0
0
218
1516
1.92
9.67
5.8
4.5
34.9
35.2
g/l
0.32
202
1408
229
1622
1.92
9.57
8.2
5.5
1.2
1.2
mmol/l
0.13
209
1464
158
994
1.95
9.40
4.5
3.1
0.1
0.4
e6/l
3.51
118
750
241
1760
1.88
8.92
9.5
6.5
1.2
1.2
mmol/l
0.01
210
1485
188
1276
1.87
8.71
4.7
3.2
—
—
—
0
0
12
17
7.24
8.03
1.9
1.6
—
—
—
0
0
104
594
2.00
7.99
3.8
2.9
1.2
1.1
e6/l
0.11
57
342
177
1203
1.82
7.98
3.1
3.6
2.3
2.3
mmol/l
0.08
153
1053
253
1932
1.79
7.55
10.8
8.9
4.4
4.2
e9/l
0.42
219
1708
377
3322
2.47
6.89
23.1
15.3
26.4
24.9
mg/l
0.38
321
2656
111
683
1.85
6.71
2.6
3.1
2.5
2.5
mmol/l
0.24
95
608
99
593
1.88
6.49
1.9
1.8
—
—
—
0
0
60
301
2.16
6.45
1.9
1.9
403.1
377.5
nmol/l
0.43
55
277
73
405
1.97
5.98
1.9
1.8
—
—
—
0
0
93
562
1.84
5.89
3.7
3.0
3.0
2.5
e6/l
0.17
46
313
72
403
1.95
5.75
2.0
1.7
—
—
—
0
0
12
25
4.91
5.53
1.1
1.3
—
—
—
0
0
254
2042
1.63
5.40
6.0
4.4
6.6
6.8
mmol/l
1.18
236
1912
45
217
2.20
5.33
1.7
1.7
—
—
—
0
0
184
1371
1.61
5.33
2.8
2.2
79.7
78.1
nmol/l
0.31
164
1203
192
1459
1.59
5.04
2.6
2.0
89.8
94.8
pmol/l
0.83
93
738
129
894
1.64
4.93
1.9
1.6
20.8
21.2
nmol/l
0.10
111
747
204
1582
1.57
4.85
4.3
4.1
—
—
—
0
0
346
3050
1.81
4.84
5.6
4.7
1.8
2.0
mu/l
1.73
313
2727
10
22
4.63
4.32
1.3
1.2
3.2
1.9
mmol/l
—
10
22
229
1858
1.52
4.21
6.6
6.2
10.1
11.3
umol/l
1.42
221
1754
294
2519
1.57
4.20
4.5
3.8
14.9
15.0
pmol/l
0.15
261
2243
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
9
14
6.54
4.00
1.3
1.2
—
—
—
0
0
9
14
6.54
4.00
1.1
1.1
—
—
—
0
0
78
500
1.69
3.95
3.3
2.3
21.1
21.2
%
0.03
67
429
12
33
3.71
3.95
2.1
2.9
—
—
—
0
0
54
312
1.84
3.90
3.3
2.8
66.7
66.3
g/l
0.11
47
286
307
2675
1.57
3.89
9.7
7.5
83.2
79.0
u/l
0.73
295
2488
213
1737
1.46
3.61
2.7
2.6
—
—
—
0
0
55
329
1.77
3.55
2.8
2.6
5.1
6.0
ug/l
0.23
47
291
6
6
10.12
3.50
1.5
1.0
—
—
—
0
0
77
509
1.63
3.46
19.8
25.7
1.5
1.3
inr
—
6
69
102
721
1.55
3.45
1.7
1.8
1129.4
1244.0
nmol/l
0.59
71
534
144
1101
1.47
3.34
2.5
2.3
51.3
56.2
u/l
1.32
131
1010
80
539
1.60
3.32
3.2
2.3
2.2
2.3
g/l
1.00
73
496
288
2513
1.48
3.29
5.3
4.2
15.7
13.3
mm/h
1.67
268
2303
86
593
1.57
3.23
3.4
2.3
11.7
12.6
umol/l
0.42
78
544
346
3151
1.59
3.10
20.6
14.4
77.5
76.6
ml/min/173m2
0.32
296
2606
32
169
1.97
3.04
1.5
2.0
1.7
1.4
g/l
0.52
27
147
19
82
2.38
2.96
1.4
1.2
—
2.4
—
0
8
32
171
1.94
2.95
9.1
8.0
24.9
24.5
mmol/l
0.46
32
159
20
89
2.31
2.91
3.4
2.0
11.2
13.2
mg/l
0.46
20
82
7
13
5.46
2.88
1.0
1.1
—
—
—
0
0
122
930
1.44
2.80
3.1
2.1
3.1
3.2
mg/l
0.05
104
795
49
305
1.69
2.77
1.6
1.8
1.6
1.6
%
0.05
39
264
5
6
8.41
2.75
1.0
1.0
—
—
—
0
0
62
411
1.60
2.75
7.8
6.5
5.2
5.0
kpa
1.01
57
397
62
412
1.59
2.72
7.8
6.5
14.2
11.9
kpa
1.76
57
399
18
80
2.31
2.64
1.4
1.2
—
—
—
0
0
62
416
1.58
2.62
3.8
4.1
231.9
241.3
u/l
0.34
56
395
52
336
1.63
2.56
4.2
3.6
2.3
2.2
mmol/l
0.07
43
262
375
3520
1.68
2.53
14.1
10.8
25.0
25.1
u/l
0.06
360
3369
61
412
1.56
2.51
7.9
6.5
2.2
1.3
mmol/l
1.16
47
326
9
26
3.51
2.49
1.2
1.1
—
—
—
0
0
7
16
4.43
2.48
1.3
2.3
—
—
—
0
0
8
21
3.86
2.47
1.4
1.0
264.3
232.5
mg/l
—
8
21
36
213
1.76
2.45
1.6
1.5
—
—
—
0
0
64
445
1.52
2.32
8.5
8.4
—
—
—
0
0
42
264
1.66
2.31
2.9
2.6
49.1
65.2
ml/min/173m2
1.96
17
111
24
127
1.94
2.31
2.2
2.1
3.0
3.1
g/l
0.21
18
101
91
683
1.43
2.24
5.2
3.6
595.2
196.7
ng/l
0.52
79
550
5
9
5.61
2.22
1.2
1.6
—
—
—
0
0
10
36
2.82
2.21
1.2
1.1
—
—
—
0
0
58
400
1.52
2.18
3.6
4.4
3.3
35.1
ug/l
0.99
46
338
95
724
1.40
2.15
1.6
1.6
1.2
1.2
mg/l
0.01
70
573
142
1156
1.35
2.14
2.5
3.1
1886.5
1455.8
ng/l
0.47
122
997
5
10
5.05
2.07
1.2
1.3
—
—
—
0
0
316
2899
1.38
2.06
24.3
16.3
38.7
39.3
%
0.54
227
1905
170
1431
1.32
2.01
4.0
2.7
123.8
134.9
ug/l
0.29
155
1295
7
21
3.37
1.97
1.6
1.7
—
—
—
0
0
7
21
3.37
1.97
1.6
1.7
—
—
—
0
0
168
1417
1.31
1.94
3.8
4.0
38.9
63.6
ng/l
0.48
135
1066
5
11
4.59
1.94
1.2
1.2
—
—
—
0
0
5
11
4.59
1.94
1.0
1.3
—
—
—
0
0
20
106
1.93
1.94
1.5
1.6
—
—
—
0
0
20
106
1.93
1.94
1.7
1.5
—
—
—
0
0
15
72
2.12
1.88
1.7
1.2
—
—
—
0
0
127
1035
1.33
1.86
3.3
3.2
40.1
32.8
u/l
1.05
122
975
11
46
2.43
1.86
1.3
1.2
—
—
—
0
0
39
256
1.58
1.84
1.5
1.6
—
—
—
0
0
24
138
1.78
1.83
2.3
2.0
—
—
—
0
0
24
138
1.78
1.83
2.2
2.0
7.9
7.4
g/l
0.56
18
105
24
138
1.78
1.83
2.2
2.0
3.7
3.8
g/l
0.17
17
99
22
124
1.82
1.79
3.3
2.9
—
—
—
0
0
22
125
1.80
1.75
2.2
2.1
10.6
10.1
g/l
0.12
16
111
5
13
3.88
1.72
1.0
1.0
—
—
—
0
0
6
19
3.19
1.66
1.3
1.0
—
—
—
0
0
7
25
2.83
1.65
1.3
1.6
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
21
120
1.79
1.65
3.0
2.4
0.3
0.4
u/ml
0.47
14
66
5
14
3.60
1.62
1.0
1.0
—
—
—
0
0
8
32
2.53
1.60
2.3
1.5
—
—
—
0
0
20
115
1.78
1.55
1.6
1.2
—
—
—
0
0
345
3253
1.36
1.55
5.3
4.9
5.9
6.0
mmol/l
0.92
312
2899
25
154
1.66
1.54
1.6
1.7
—
—
—
0
0
191
1676
1.26
1.53
6.4
5.1
0.0
0.0
estimate
0.50
29
331
11
51
2.19
1.52
1.3
1.3
—
—
—
0
0
18
102
1.80
1.47
1.3
1.3
—
—
—
0
0
9
38
2.40
1.46
1.2
1.1
—
—
—
0
0
7
28
2.52
1.46
1.3
1.1
—
—
—
0
0
6
22
2.75
1.44
6.0
1.9
—
—
—
0
0
9
39
2.34
1.44
1.2
1.7
—
—
—
0
0
5
17
2.96
1.36
1.0
1.2
—
—
—
0
0
5
17
2.96
1.36
1.0
1.3
—
—
—
0
0
191
1693
1.24
1.35
5.0
3.8
0.0
0.0
estimate
0.00
29
319
18
105
1.75
1.35
1.2
1.2
—
—
—
0
0
18
105
1.75
1.35
1.2
1.2
—
—
—
0
0
9
42
2.17
1.34
1.2
1.7
—
—
—
0
0
84
677
1.30
1.32
1.3
1.2
1.1
1.7
u/ml
0.43
25
184
6
24
2.52
1.31
1.2
1.1
—
—
—
0
0
5
18
2.80
1.29
1.2
1.8
—
—
—
0
0
5
18
2.80
1.29
1.2
1.8
—
—
—
0
0
187
1664
1.23
1.25
5.0
3.8
0.0
0.0
estimate
0.00
29
333
84
682
1.29
1.25
3.6
3.1
1.0
0.8
ug/l
1.03
57
463
13
70
1.88
1.25
1.3
1.4
—
—
—
0
0
6
25
2.42
1.25
1.0
1.0
—
—
—
0
0
12
63
1.93
1.24
1.7
1.5
2.0
4.3
iu/l
—
5
19
5
19
2.65
1.22
1.2
1.8
—
—
—
0
0
31
216
1.47
1.17
1.9
2.4
12.7
12.5
nmol/l
0.02
25
189
8
39
2.07
1.16
1.1
1.1
—
—
—
0
0
5
20
2.52
1.15
1.4
1.3
—
—
—
0
0
5
20
2.52
1.15
1.4
1.3
—
—
—
0
0
12
65
1.87
1.14
1.3
1.2
—
—
—
0
0
12
65
1.87
1.14
1.3
1.2
—
—
—
0
0
14
80
1.78
1.14
2.2
2.3
129.6
126.0
g/l
—
7
59
12
66
1.84
1.10
1.4
1.2
—
—
—
0
0
346
3312
1.27
1.02
5.7
5.2
2.6
2.7
mmol/l
1.41
313
2992
15
91
1.67
1.02
1.4
1.6
13674.1
23456.0
e6/l
—
10
66
328
3122
1.24
1.01
6.7
6.2
40.9
40.5
mmol/mol
0.28
291
2862
5
23
2.19
0.98
1.2
1.7
—
—
—
0
0
5
23
2.19
0.98
1.2
1.7
—
—
—
0
0
5
23
2.19
0.98
1.2
1.7
—
—
—
0
0
5
23
2.19
0.98
1.2
1.7
—
—
—
0
0
5
23
2.19
0.98
1.2
1.2
—
—
—
0
0
5
23
2.19
0.98
1.2
1.2
—
—
—
0
0
0
29
0.00
0.98
0.0
1.7
—
—
—
0
0
15
93
1.64
0.95
2.1
1.5
—
—
—
0
0
32
235
1.39
0.95
3.8
3.7
2.8
2.0
mmol/l
0.34
24
178
34
255
1.36
0.90
3.8
3.5
5.1
5.2
kpa
0.26
29
237
19
128
1.51
0.87
1.0
1.0
—
—
—
0
0
0
27
0.00
0.77
0.0
1.2
—
—
—
0
0
16
107
1.52
0.77
1.4
1.5
299.5
280.9
ug/g
0.14
11
59
14
91
1.56
0.76
2.4
2.3
—
—
—
0
0
5
24
2.10
0.74
1.0
1.2
—
—
—
0
0
5
24
2.10
0.74
1.2
1.2
—
—
—
0
0
5
24
2.10
0.74
1.2
1.2
—
—
—
0
0
5
24
2.10
0.74
1.2
1.2
—
—
—
0
0
25
185
1.37
0.74
1.8
1.7
—
—
—
0
0
5
25
2.01
0.73
1.4
1.3
—
—
—
0
0
5
25
2.01
0.73
1.4
1.3
—
—
—
0
0
108
962
1.17
0.67
4.4
4.7
23.0
21.4
%
0.54
55
482
134
1217
1.15
0.64
5.8
5.4
3.8
3.8
ug/l
0.00
114
1058
5
29
1.73
0.64
1.2
1.6
—
—
—
0
0
26
200
1.32
0.62
2.0
1.8
—
—
—
0
0
10
63
1.60
0.62
1.2
1.6
—
—
—
0
0
125
1133
1.15
0.61
4.7
4.1
12.8
9.1
mg/mmol
0.30
90
701
8
51
1.58
0.60
1.1
1.5
—
—
—
0
0
21
158
1.35
0.58
1.3
1.3
—
—
—
0
0
5
86
0.58
0.57
1.0
1.1
—
18.4
—
0
9
6
37
1.63
0.55
1.5
1.7
—
—
—
0
0
6
37
1.63
0.55
1.5
1.7
—
—
—
0
0
6
37
1.63
0.55
1.5
1.7
—
—
—
0
0
11
74
1.50
0.54
1.1
1.6
—
—
—
0
0
6
39
1.55
0.53
3.5
2.3
—
—
—
0
0
44
371
1.21
0.52
4.3
3.5
—
—
—
0
0
6
40
1.51
0.52
2.3
2.8
27.0
71.8
u/ml
—
6
40
333
3234
1.15
0.52
5.1
4.6
4.5
4.6
mmol/l
1.30
301
2937
9
65
1.39
0.51
1.2
1.3
—
—
—
0
0
10
68
1.48
0.47
1.1
1.9
44.7
43.7
nmol/l
—
10
63
219
2085
1.11
0.45
3.7
3.0
51.3
51.3
u/l
0.00
199
1896
39
454
0.84
0.42
1.5
1.4
—
—
—
0
0
18
141
1.29
0.41
1.7
1.6
—
—
—
0
0
8
61
1.32
0.39
1.1
1.5
—
—
—
0
0
5
35
1.43
0.39
1.6
1.3
—
—
—
0
0
87
795
1.12
0.39
1.7
1.8
486.3
8865131.5
pmol/l
0.50
67
643
11
80
1.39
0.39
1.4
1.6
—
—
—
0
0
53
469
1.15
0.38
5.7
4.8
31.7
32.6
%
0.26
34
298
5
36
1.39
0.38
1.2
1.5
—
—
—
0
0
62
556
1.14
0.37
1.3
1.3
24.9
34.5
iu/ml
0.40
17
182
9
69
1.31
0.37
1.1
1.1
—
—
—
0
0
22
180
1.23
0.36
3.2
2.6
0.6
0.7
%
0.62
22
174
6
88
0.68
0.33
1.3
1.4
—
—
—
0
0
11
83
1.33
0.32
1.5
1.3
—
—
—
0
0
7
54
1.30
0.30
1.1
1.5
—
—
—
0
0
11
84
1.32
0.30
1.4
1.6
—
—
—
0
0
328
3215
1.10
0.30
5.0
4.6
1.4
1.5
mmol/l
1.78
297
2897
27
233
1.17
0.28
3.3
3.3
124.2
124.9
g/l
0.05
27
227
99
935
1.08
0.24
6.1
4.1
0.0
0.0
estimate
0.50
28
323
11
88
1.26
0.22
1.2
1.3
—
—
—
0
0
5
40
1.25
0.22
1.8
1.3
—
—
—
0
0
317
3117
1.07
0.22
4.7
4.1
1.3
1.3
mmol/l
0.30
281
2797
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
7.1
—
—
—
0
0
0
12
0.00
0.21
0.0
5.2
—
220.0
—
0
12
6
49
1.23
0.20
1.2
1.6
—
—
—
0
0
6
50
1.20
0.20
1.3
1.5
—
—
—
0
0
6
52
1.16
0.19
1.3
1.4
—
—
—
0
0
6
53
1.13
0.18
1.3
1.4
—
—
—
0
0
6
53
1.13
0.18
1.3
1.4
—
—
—
0
0
6
53
1.13
0.18
1.3
1.4
—
—
—
0
0
6
53
1.13
0.18
1.3
1.4
—
—
—
0
0
21
185
1.14
0.18
1.2
1.1
50.5
105.5
iu/ml
—
8
69
5
67
0.74
0.17
1.4
1.2
79.7
44.3
u/l
—
5
56
8
69
1.16
0.16
1.5
1.4
—
—
—
0
0
21
188
1.12
0.15
4.3
3.5
24.9
25.0
mmol/l
0.03
21
183
19
210
0.90
0.12
2.0
1.6
—
—
—
0
0
93
898
1.05
0.12
3.5
2.7
366.9
7898.6
umol/l
4.31
82
764
5
45
1.11
0.10
1.0
1.0
—
—
—
0
0
6
54
1.11
0.09
1.3
1.4
—
—
—
0
0
12
107
1.13
0.08
1.7
1.7
2.2
2.3
mg/l
—
7
78
8
91
0.88
0.07
1.6
1.5
—
—
—
0
0
85
868
0.97
0.05
1.6
1.6
1.4
1.4
mmol/l
0.37
73
702
12
110
1.09
0.05
1.3
1.8
—
124.0
—
0
5
130
1316
0.98
0.04
5.5
4.1
—
—
—
0
0
55
540
1.02
0.02
1.3
1.2
6.2
9.4
u/ml
0.27
17
203
19
185
1.03
0.00
3.5
3.7
54.6
48.3
%
0.58
19
180
19
195
0.97
0.00
3.6
3.0
0.2
0.3
e6/l
0.15
19
190
42
416
1.01
0.00
1.5
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
108.5
—
0
6
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
5
53
0.94
0.00
1.2
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
1.3
—
0
7
6
68
0.88
0.00
1.2
1.1
0.5
0.9
nmol/l
—
6
54
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_LAGOPHTALMOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_LAGOPHTALMOS | 1.358 [1.15, 1.61] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.529 |
During the follow-up period (1.1.1998 — 31.12.2019), 392 out of 1238 females with H7_LAGOPHTALMOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_LAGOPHTALMOS | 1.744 [1.42, 2.14] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 375 out of 944 males with H7_LAGOPHTALMOS died.
Mortality risk
Mortality risk for people of age
years, who have H7_LAGOPHTALMOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.119% | 0.273% |
| 5 | 0.782% | 1.808% |
| 10 | 2.201% | 4.344% |
| 15 | 4.166% | 8.147% |
| 20 | 6.923% | 13.65% |
Relationships between endpoints
↥Index endpoint: H7_LAGOPHTALMOS – Lagophthalmos
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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