Mild or no visual impairment, binocular

H7_MILDVISIMPBINOC

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H54.3
  • Cause of death: ICD-10 H54.3

2 out of 7 registries used, show all original rules.

183

4. Check minimum number of events

None

183

5. Include endpoints

None

183

6. Filter based on genotype QC (FinnGen only)

172

Control definitions (FinnGen only)

Control exclude
H7_VISUALDISTBLIND

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H54
Name in latin
Amblyopia non specificata oculorum amborum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1613 870 732
Only index persons 1433 791 642
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 42.74 48.39 35.96
Only index persons 44.24 49.24 38.09

-FinnGen-

Key figures

All Female Male
Number of individuals 172 118 54
Unadjusted period prevalence (%) 0.04 0.04 0.02
Median age at first event (years) 55.70 53.01 61.58

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
183
Matched controls
1830
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H54.3
ICD-10 Finland
Mild or no visual impairment, binocular
+∞
264.8
183
*
XCK00
NOMESCO Finland
Perimetry
18.2
57.8
52
39
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
+∞
37.8
35
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
8.8
34.3
51
77
H53.4
ICD-10 Finland
Visual field defects
185.3
30.7
31
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
6.9
29.9
57
112
Z3229
NOMESCO Finland
Other healthcare associate professional
7.2
26.8
47
84
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
7.3
24.3
41
70
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
8.7
24.2
34
47
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.2
24.1
68
188
H53.1
ICD-10 Finland
Subjective visual disturbances
26.3
22.6
31
14
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.2
21.2
42
84
XCK10
NOMESCO Finland
Photography of fundus of eye
6.0
20.1
41
84
H47.2
ICD-10 Finland
Optic atrophy
+∞
19.1
18
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
20.9
18.4
27
15
ZXA10
NOMESCO Finland
Bilateral
4.0
16.2
60
198
N03AG01
ATC
valproic acid; systemic, rectal
6.4
16.1
29
52
R56.8
ICD-10 Finland
Other and unspecified convulsions
6.4
13.6
24
42
SPAT1229
SPAT
Assessment of need for aid
5.9
13.4
26
50
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
6.4
13.1
23
40
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.1
12.6
101
524
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
13.8
12.5
21
17
R4120
NOMESCO Finland
Occupational therapy
5.3
11.6
25
53
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
127.7
11.6
12
*
H54.7
ICD-10 Finland
Unspecified visual loss
37.6
11.4
14
*
TAB00
NOMESCO Finland
Lumbar puncture
6.0
11.2
21
39
AA1AD
NOMESCO Finland
CT of head and brain
3.1
11.1
63
266
H04.10
ICD-10 Finland
Dry eye syndrome
3.9
10.7
36
109
H54.0
ICD-10 Finland
Blindness, binocular
+∞
10.5
10
*
N03AX14
ATC
levetiracetam; systemic
14.3
10.4
17
13
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
42.6
10.1
12
*
Z2446
NOMESCO Finland
Social worker
4.3
9.9
28
74
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
5.1
9.8
22
48
R50.9
ICD-10 Finland
Fever, unspecified
3.2
9.3
44
165
ZXA00
NOMESCO Finland
Right side
2.8
9.2
63
290
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.6
9.2
34
109
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.5
9.1
24
60
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
8.3
8.9
19
25
A28
ICPC
Limited function/disability NOS
3.1
8.8
43
164
R4110
NOMESCO Finland
Physiotherapy
2.7
8.8
65
311
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
52.6
8.8
10
*
H02AB06
ATC
prednisolone; systemic
2.5
8.7
102
609
N02AX02
ATC
tramadol; systemic, rectal
2.5
8.6
86
476
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
4.2
8.6
24
63
R3120
NOMESCO Finland
Training in mobility skills
94.2
8.5
9
*
H53.0
ICD-10 Finland
Amblyopia ex anopsia
+∞
8.4
8
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
8.8
8.3
17
21
CS494
NOMESCO Finland
Other visual field testing
12.5
8.2
14
12
Z3231
NOMESCO Finland
Registered nurse
2.5
8.2
70
358
N03AX09
ATC
lamotrigine; oral
4.7
8.2
20
47
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.9
8.0
25
71
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
8.0
76
407
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.2
8.0
36
131
H53.9
ICD-10 Finland
Visual disturbance, unspecified
11.5
7.9
14
13
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.4
7.9
31
103
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
12.6
7.7
13
11
H53.2
ICD-10 Finland
Diplopia
26.3
7.7
10
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.8
7.6
18
41
WX408
NOMESCO Finland
General anesthesy, balanced
2.6
7.6
57
272
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.6
7.6
27
84
H54.1
ICD-10 Finland
Severe visual impairment, binocular
+∞
7.3
7
*
R42
ICD-10 Finland
Dizziness and giddiness
2.6
7.3
52
242
N99
ICPC
Neurological disease other
31.4
7.2
9
*
Z2221
NOMESCO Finland
Medical doctor
2.4
7.2
64
330
L28
ICPC
Limited function/disability (L)
2.8
7.0
42
178
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
41.6
6.8
8
*
H46
ICD-10 Finland
Optic neuritis
41.6
6.8
8
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
41.6
6.8
8
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.3
6.8
80
464
WX140
NOMESCO Finland
Parabulbar anesthesy
6.3
6.8
17
29
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.8
6.8
39
162
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.9
6.7
35
138
K90
ICPC
Stroke/cerebrovascular accident
10.6
6.6
12
12
N03AF02
ATC
oxcarbazepine; oral
6.1
6.6
17
30
Z3226
NOMESCO Finland
Physiotherapist
2.6
6.6
47
217
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
72.3
6.5
7
*
ZXE00
NOMESCO Finland
One hour or less
2.2
6.4
82
490
XF400
NOMESCO Finland
ECG with 12 standard connections
2.7
6.3
38
161
G80.9
ICD-10 Finland
Cerebral palsy, unspecified
+∞
6.3
6
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.6
6.2
21
63
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
6.2
49
238
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.2
6.1
25
85
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.2
6.1
84
514
Z01.8
ICD-10 Finland
Other specified special examinations
2.5
6.1
45
211
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.5
6.1
22
69
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
6.1
57
298
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.6
6.0
41
185
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.2
6.0
25
86

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
114
668
2.87
10.82
7.8
6.2
1.21
1.22
mmol/l
0.88
101
573
129
816
2.97
10.43
7.8
4.3
6.66
6.50
mmol/l
0.33
121
753
100
556
2.76
10.37
4.7
4.3
35.89
35.77
g/l
0.08
93
525
103
601
2.63
9.41
7.9
5.8
1.21
1.22
mmol/l
0.68
95
552
102
601
2.58
9.01
12.2
11.4
1.28
1.21
inr
0.21
24
171
107
652
2.54
8.70
9.9
5.9
0.61
0.64
%
0.19
100
609
67
327
2.65
8.69
4.8
3.9
—
—
—
0
0
109
674
2.53
8.53
11.6
6.2
7.88
8.23
%
0.69
101
637
110
686
2.51
8.41
9.5
5.8
59.14
56.47
%
1.38
103
652
108
668
2.50
8.40
10.2
5.9
2.48
2.77
%
0.72
100
628
108
674
2.47
8.16
9.7
6.5
—
—
—
0
0
52
230
2.76
8.12
4.0
3.7
202.74
144.37
ng/l
0.16
39
164
115
741
2.49
8.06
9.7
6.2
0.17
0.19
e9/l
0.55
104
656
110
696
2.46
8.00
10.7
6.0
27.27
29.08
%
0.94
103
664
77
431
2.36
7.20
3.2
2.2
50.34
68.78
u/l
1.02
68
401
110
720
2.32
7.09
9.4
5.9
0.57
0.55
e9/l
0.29
96
625
110
720
2.32
7.09
9.3
6.0
0.04
0.04
e9/l
0.11
97
623
112
743
2.31
6.93
9.3
5.9
1.93
2.08
e9/l
0.39
104
665
77
443
2.27
6.65
2.4
2.1
—
—
—
0
0
86
524
2.21
6.40
2.2
1.9
97.67
96.26
pmol/l
0.09
46
263
35
142
2.81
6.33
5.3
5.3
0.97
1.03
mmol/l
0.03
28
112
17
44
4.16
6.14
2.1
2.7
—
—
—
0
0
23
77
3.27
5.77
1.7
2.9
—
—
—
0
0
117
830
2.14
5.63
11.8
9.2
4.45
4.01
e9/l
1.16
103
730
37
165
2.56
5.54
6.2
5.7
0.99
1.13
mmol/l
2.52
37
151
54
287
2.25
5.48
3.7
2.6
6.78
5.05
e6/l
0.78
49
256
10
11
9.54
5.36
1.6
1.4
—
—
—
0
0
104
718
2.04
5.25
7.1
5.6
9.04
11.79
umol/l
2.75
93
685
24
88
2.99
5.18
7.7
6.3
24.42
24.81
mmol/l
0.26
24
88
21
73
3.12
4.95
5.0
4.1
—
—
—
0
0
139
1080
2.19
4.95
10.1
6.7
79.60
81.33
u/l
0.22
131
1008
20
69
3.13
4.77
3.7
3.9
—
—
—
0
0
136
1061
2.10
4.60
5.1
3.9
14.74
11.69
mm/h
1.18
120
975
28
120
2.57
4.52
2.1
2.2
0.22
0.22
g/l
0.08
28
115
12
24
5.27
4.40
1.2
2.6
—
—
—
0
0
77
505
1.91
4.26
5.7
4.0
197.56
47.98
e6/l
0.84
55
354
63
387
1.96
4.23
4.7
3.1
—
—
—
0
0
28
125
2.46
4.15
3.3
4.2
—
—
—
0
0
69
440
1.91
4.13
4.5
2.9
—
—
—
0
0
53
312
1.98
3.99
2.3
1.9
1.18
1.38
mg/l
0.18
39
237
20
77
2.79
3.96
7.3
6.4
93.82
94.21
%
0.15
20
77
63
397
1.90
3.87
4.7
3.2
0.43
0.35
e6/l
0.20
46
289
70
460
1.84
3.76
5.1
3.8
25.04
22.34
ng/l
0.22
51
316
67
438
1.84
3.64
4.9
3.2
120.29
59.90
e6/l
0.32
52
332
47
275
1.95
3.57
3.9
3.0
561.51
556.40
mosm/kgh2o
0.06
41
239
26
122
2.32
3.46
1.8
1.4
—
—
—
0
0
52
318
1.89
3.46
3.1
2.9
324.22
11178.76
umol/l
2.51
46
271
31
158
2.16
3.40
3.7
1.5
—
—
—
0
0
26
124
2.28
3.34
9.6
6.5
—
—
—
0
0
31
161
2.11
3.24
4.3
2.6
5.28
8.49
umol/l
1.23
25
138
122
981
1.73
3.03
6.5
4.3
—
—
—
0
0
54
348
1.78
3.00
2.5
2.0
3.00
3.25
mg/l
0.35
46
306
60
400
1.74
2.96
5.6
3.9
7.43
7.40
ph
2.22
11
72
148
1271
1.86
2.78
6.4
5.2
40.18
39.36
mmol/mol
0.43
134
1191
163
1446
2.16
2.77
22.9
12.4
23.15
21.35
mg/l
0.29
144
1106
49
314
1.77
2.75
1.9
1.4
16.55
22.63
nmol/l
2.37
44
272
32
179
1.95
2.74
2.6
2.1
2.39
2.42
g/l
0.09
27
164
30
165
1.98
2.69
1.2
1.2
—
—
—
0
0
29
482
0.53
2.60
2.7
2.7
—
—
—
0
0
7
16
4.50
2.50
1.0
1.6
—
—
—
0
0
15
64
2.46
2.46
5.3
7.1
—
—
—
0
0
10
33
3.14
2.39
1.3
1.4
—
—
—
0
0
6
13
4.73
2.29
1.2
1.2
—
—
—
0
0
6
13
4.73
2.29
1.0
1.3
—
—
—
0
0
131
1112
1.63
2.28
5.4
4.0
14.47
14.63
pmol/l
0.29
115
1013
63
454
1.59
2.23
2.8
2.8
2.35
2.36
mmol/l
0.26
55
400
49
332
1.65
2.22
1.7
1.5
2.44
2.18
g/l
0.28
27
191
28
161
1.87
2.22
6.2
4.8
105.82
104.54
mmol/l
1.10
28
161
36
224
1.76
2.21
2.9
2.5
2.46
2.45
mmol/l
0.40
29
192
54
379
1.60
2.12
9.1
7.3
—
—
—
0
0
52
362
1.61
2.11
1.3
1.3
0.87
1.71
u/ml
—
6
89
36
228
1.72
2.08
4.1
3.1
1.85
2.59
e6/l
0.34
17
127
21
112
1.99
2.06
1.6
1.3
—
—
—
0
0
6
15
4.10
2.05
1.0
1.3
—
—
—
0
0
6
15
4.10
2.05
1.0
1.3
—
—
—
0
0
9
33
2.81
1.96
1.3
1.4
—
60.00
—
0
5
6
16
3.84
1.95
8.2
4.4
25.33
23.75
nmol/l
—
6
16
51
362
1.57
1.89
3.7
3.1
35.81
278.57
mg/l
0.78
33
235
151
1352
1.67
1.87
6.3
4.7
1.83
1.86
mu/l
0.10
137
1239
37
245
1.64
1.82
1.8
1.7
1003.28
1140.40
nmol/l
0.48
26
194
7
23
3.12
1.82
2.6
2.3
—
—
—
0
0
8
29
2.84
1.81
1.5
1.6
—
—
—
0
0
6
18
3.41
1.76
1.5
1.2
—
—
—
0
0
6
18
3.41
1.76
1.5
1.4
—
—
—
0
0
30
191
1.68
1.71
1.7
1.4
683.64
523.00
titre
0.24
11
40
81
648
1.45
1.66
3.7
2.6
104.11
91.42
ug/l
0.22
74
602
55
409
1.49
1.63
3.8
3.4
7.28
7.63
mmol/l
0.21
50
356
10
43
2.40
1.61
2.1
3.4
1.98
1.61
%
—
10
38
6
20
3.07
1.59
1.3
1.2
—
—
—
0
0
52
385
1.49
1.57
4.2
3.7
9.54
14.42
mg/mmol
0.43
33
236
5
15
3.40
1.53
1.2
1.4
—
—
—
0
0
51
380
1.47
1.49
4.5
4.0
—
—
—
0
0
27
175
1.64
1.45
1.9
1.4
—
—
—
0
0
69
549
1.41
1.42
2.5
2.0
—
—
—
0
0
81
664
1.39
1.40
12.2
8.9
0.00
0.00
e9/l
0.51
69
529
5
17
2.99
1.37
1.0
1.4
—
—
—
0
0
5
17
2.99
1.37
1.2
3.4
—
—
—
0
0
10
47
2.19
1.36
1.6
1.3
—
—
—
0
0
14
76
1.91
1.34
7.7
5.8
24.61
24.74
mmol/l
0.05
14
70
48
363
1.44
1.29
1.6
1.6
1.51
1.33
mmol/l
0.65
40
314
9
44
2.10
1.29
6.8
5.1
—
—
—
0
0
16
93
1.79
1.26
2.6
3.0
77.41
69.41
e9/l
—
10
77
6
25
2.45
1.25
1.2
1.6
2145.83
30234.63
e6/l
—
6
19
27
182
1.57
1.25
2.0
1.8
—
—
—
0
0
5
19
2.68
1.22
1.2
1.1
—
—
—
0
0
8
38
2.15
1.20
2.9
1.2
—
—
—
0
0
5
20
2.54
1.16
2.4
2.7
—
—
—
0
0
53
418
1.38
1.12
1.4
1.6
—
—
—
0
0
16
98
1.69
1.07
4.5
4.6
0.80
0.69
%
—
5
29
17
106
1.67
1.07
1.6
1.4
—
—
—
0
0
5
22
2.31
1.04
1.8
3.0
—
—
—
0
0
5
22
2.31
1.04
1.0
1.7
—
—
—
0
0
7
135
0.50
1.03
1.1
1.3
—
—
—
0
0
7
35
2.04
1.01
1.9
5.6
1.26
1.09
mmol/l
—
7
29
162
1529
1.52
1.00
17.1
11.3
—
—
—
0
0
104
918
1.31
1.00
4.1
3.6
—
—
—
0
0
5
23
2.21
0.98
2.2
2.3
3.78
5.76
u/ml
—
5
23
9
50
1.84
0.98
1.9
1.2
—
—
—
0
0
169
1613
1.62
0.94
31.6
18.7
255.47
255.32
e9/l
0.01
169
1575
41
319
1.37
0.94
4.3
3.7
—
—
—
0
0
9
52
1.77
0.94
1.2
1.1
—
—
—
0
0
169
1615
1.61
0.91
32.1
18.6
90.83
90.52
fl
0.32
169
1591
169
1615
1.61
0.91
32.0
18.5
30.08
30.14
pg
0.15
169
1591
169
1615
1.61
0.91
32.1
18.6
4.44
4.48
e12/l
0.45
169
1570
16
103
1.61
0.91
6.8
5.0
0.00
0.19
%
—
6
32
169
1616
1.60
0.89
32.2
18.6
7.15
6.69
e9/l
1.84
169
1571
169
1616
1.60
0.89
32.4
18.7
132.90
134.26
g/l
0.66
169
1591
22
154
1.49
0.88
1.5
1.3
—
—
—
0
0
10
57
1.80
0.85
1.8
1.3
—
—
—
0
0
20
139
1.49
0.83
1.4
1.2
—
—
—
0
0
6
32
1.90
0.82
2.0
1.5
—
—
—
0
0
15
98
1.58
0.81
6.7
5.1
0.00
0.31
%
—
5
26
11
173
0.61
0.80
1.0
1.5
—
—
—
0
0
145
1359
1.32
0.78
5.3
4.2
6.01
5.86
mmol/l
0.43
132
1249
6
34
1.79
0.77
1.8
1.2
—
—
—
0
0
147
1383
1.32
0.75
5.2
4.6
2.70
2.79
mmol/l
0.60
136
1282
9
55
1.67
0.75
1.6
1.5
—
—
—
0
0
16
109
1.51
0.74
11.5
7.4
7.78
9.27
mmol/l
0.55
16
104
9
58
1.58
0.71
1.2
1.2
—
—
—
0
0
5
27
1.87
0.69
1.0
1.7
—
—
—
0
0
16
111
1.48
0.68
6.8
4.9
0.67
1.01
%
—
6
40
10
63
1.62
0.63
1.8
1.3
—
—
—
0
0
5
30
1.68
0.62
2.8
1.7
—
—
—
0
0
5
30
1.68
0.62
4.4
2.8
5.61
5.20
e9/l
—
5
30
5
30
1.68
0.62
4.6
3.0
67.20
60.70
%
—
5
30
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
23
176
1.35
0.60
1.7
1.4
—
—
—
0
0
10
64
1.60
0.60
1.8
1.3
—
—
—
0
0
10
64
1.60
0.60
1.8
1.3
—
—
—
0
0
26
204
1.32
0.58
3.0
2.2
88.50
121.96
ug/g
0.41
18
166
138
1303
1.24
0.58
4.1
3.8
1.33
1.25
mmol/l
0.69
121
1202
10
65
1.57
0.56
1.8
1.3
—
—
—
0
0
31
252
1.28
0.54
1.3
1.3
12.72
41.70
iu/ml
—
5
92
77
694
1.19
0.51
4.5
3.8
0.00
0.00
estimate
-0.00
13
127
33
393
0.80
0.49
4.4
3.3
—
—
—
0
0
7
45
1.58
0.49
1.6
3.0
—
—
—
0
0
11
154
0.70
0.49
2.6
2.0
—
—
—
0
0
143
1364
1.22
0.49
4.6
4.2
4.57
4.68
mmol/l
0.68
132
1275
31
256
1.25
0.48
1.9
1.6
—
—
—
0
0
7
48
1.48
0.47
3.0
1.5
—
—
—
0
0
37
313
1.23
0.47
2.2
1.9
—
—
—
0
0
142
1357
1.21
0.45
4.5
4.1
1.44
1.51
mmol/l
1.03
128
1259
10
69
1.48
0.45
2.5
2.5
6094.22
5161.99
u/l
—
5
25
0
15
0.00
0.41
0.0
4.9
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
32
272
1.21
0.39
1.5
1.7
409.38
464.53
pmol/l
0.68
26
231
75
690
1.15
0.37
6.4
5.3
0.00
0.00
estimate
-0.00
13
133
74
689
1.12
0.29
4.6
3.8
0.00
0.00
estimate
-0.00
12
138
7
57
1.24
0.29
1.6
1.5
—
—
—
0
0
8
65
1.24
0.27
2.5
3.2
0.74
0.70
%
—
8
65
41
374
1.12
0.23
4.4
3.8
0.00
0.00
estimate
-0.00
11
126
32
288
1.13
0.22
4.7
4.9
1.79
3.23
ug/l
0.66
25
259
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
32.93
—
0
14
29
319
0.89
0.18
5.2
3.8
1.02
1.02
kg/l
—
5
51
8
69
1.17
0.16
2.5
3.1
1.36
1.25
%
—
8
69
8
69
1.17
0.16
2.7
2.2
—
—
—
0
0
21
187
1.14
0.16
1.6
1.7
—
—
—
0
0
10
118
0.84
0.14
4.9
3.5
—
—
—
0
0
19
172
1.12
0.12
3.3
2.8
0.67
0.77
ug/l
0.15
14
118
6
55
1.09
0.09
1.0
1.1
—
—
—
0
0
6
73
0.82
0.08
4.3
3.6
—
—
—
0
0
10
91
1.10
0.04
5.3
2.4
—
—
—
0
0
19
180
1.06
0.04
1.3
1.2
—
—
—
0
0
26
250
1.05
0.03
1.4
1.3
1.84
10.33
u/ml
—
5
103
12
119
1.01
0.00
1.4
1.4
—
—
—
0
0
10
97
1.03
0.00
5.0
3.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.8
—
—
—
0
0
7
76
0.92
-0.00
1.1
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
211.61
—
0
7
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
8
85
0.94
-0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1537.50
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
30.4
—
245.34
—
0
5

Mortality – FinRegistry

Association

Association between endpoint H7_MILDVISIMPBINOC and mortality.

Females

Parameter HR [95% CI] p-value
H7_MILDVISIMPBINOC 1.814 [1.3, 2.54] < 0.001
Birth year 0.997 [0.99, 1.01] 0.541

During the follow-up period (1.1.1998 — 31.12.2019), 182 out of 791 females with H7_MILDVISIMPBINOC died.

Males

Parameter HR [95% CI] p-value
H7_MILDVISIMPBINOC 2.239 [1.54, 3.26] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 181 out of 685 males with H7_MILDVISIMPBINOC died.

Mortality risk

Mortality risk for people of age

years, who have H7_MILDVISIMPBINOC.

N-year risk Females Males
1 0.192% 0.38%
5 1.068% 2.285%
10 2.739% 5.686%
15 5.429% 11.097%
20 9.766% 18.066%

Relationships between endpoints

Index endpoint: H7_MILDVISIMPBINOC – Mild or no visual impairment, binocular

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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