intracranial embolism: Blocking of a blood vessel in the skull by an embolus which can be a blood clot (thrombus) or other undissolved material in the blood stream. Most emboli are of cardiac origin and are associated with heart diseases. Other non-cardiac sources of emboli are usually associated with vascular diseases.
Occlusion and stenosis of arteries, not leading to stroke
DOID EFO Endpoint Browser PheWeb
I9_STENOSIS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
574 |
4. Check minimum number of eventsNone |
574 |
5. Include endpointsNone |
574 |
6. Filter based on genotype QC (FinnGen only) |
552 |
Control definitions (FinnGen only)
- Control exclude
- I9_CEREBVASC
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- I60-I69
- Name in latin
- Occlusio sive stenosis arteriarum cerebralium sine infarctu
Similar endpoints
↥List of similar endpoints to
Occlusion and stenosis of arteries, not leading to stroke
based on the number of shared cases.
Similar with more cases:
- Cerebrovascular diseases (FINNGEN)
- Cerebrovascular diseases
- Neurological diseases, wide definition
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7018 | 2849 | 3990 |
| Only index persons | 3710 | 1691 | 2019 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.08 | 0.11 |
| Only index persons | 0.07 | 0.06 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 67.81 | 70.75 | 65.76 |
| Only index persons | 65.92 | 68.76 | 63.54 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 552 | 179 | 373 |
| Unadjusted period prevalence (%) | 0.14 | 0.06 | 0.17 |
| Median age at first event (years) | 63.21 | 63.23 | 63.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 574
- Matched controls
- 5740
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
147.5
320.1
160
15
4331X
ICD-9 Finland
Occlusion and stenosis of precerebral arteries, Carotid artery[OCCL/STENOSIS ARTERIAE CAROTIS SINE INFARCTU CEREBR]
+∞
241.2
214
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
367.3
185.7
178
7
5541
FHL
Subclavia and / or carotid endarterectomy, reconstruction or bypass surgery
1707.9
141.9
132
*
B01AC07
ATC
dipyridamole; systemic
10.1
122.9
165
221
I66.9
ICD-10 Finland
Occlusion and stenosis of unspecified cerebral artery
+∞
121.2
112
*
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
11.5
102.3
117
125
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
7.4
75.5
126
211
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
780.3
71.7
69
*
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
780.3
71.7
69
*
I66.0
ICD-10 Finland
Occlusion and stenosis of middle cerebral artery
+∞
55.1
52
*
G46.0*I66.0
ICD-10 Finland
Middle cerebral artery syndrome
+∞
52.9
50
*
B01AC04
ATC
clopidogrel; oral
3.7
41.3
172
598
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
+∞
41.1
39
*
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
9.0
40.4
52
63
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
11.3
38.8
42
40
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
+∞
37.9
36
*
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
+∞
36.9
35
*
4340A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral thrombosis
+∞
35.8
34
*
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
8.4
35.4
48
62
4351A
ICD-9 Finland
Transient cerebral ischaemia, Vertebral artery syndrome
53.6
33.9
40
8
4331A
ICD-9 Finland
Occlusion and stenosis of precerebral arteries, Carotid artery[OCCL/STENOSIS ARTERIAE CAROTIS CUM INFARCTU CEREBRI]
+∞
32.6
31
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.5
32.1
137
476
4402A
ICD-9 Finland
Atherosclerosis, Of native arteries of the extremities
7.7
31.8
46
64
G46.2*I66.2
ICD-10 Finland
Posterior cerebral artery syndrome
+∞
31.5
30
*
XA800
NOMESCO Finland
Neuropsychological investigation
10.3
31.5
36
37
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
7.3
30.1
46
68
I66.8
ICD-10 Finland
Occlusion and stenosis of other cerebral artery
+∞
28.4
27
*
AA1AD
NOMESCO Finland
CT of head and brain
2.7
26.0
195
920
K90
ICPC
Stroke/cerebrovascular accident
23.9
25.5
36
16
I66.3
ICD-10 Finland
Occlusion and stenosis of cerebellar arteries
+∞
24.1
23
*
I63.5
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
+∞
22.0
21
*
4339X
ICD-9 Finland
Occlusion and stenosis of precerebral arteries, Unspecified precerebral artery[OCCL/STENOSIS ARTER.PRAECEREBRALES NUD SINE INFARCT]
+∞
22.0
21
*
205
Kela drug reimbursment
Chronic hypertension
2.3
21.3
250
1424
PEF23
NOMESCO Finland
Thrombendarterectomy of femoral artery
8.0
21.0
29
38
4380A
ICD-9 Finland
Late effects of cerebrovascular disease[SEQUELAE MORBI CEREBROVASCULARIS]
+∞
21.0
20
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.9
20.5
64
178
I63.1
ICD-10 Finland
Cerebral infarction due to embolism of precerebral arteries
+∞
18.9
18
*
B01AA03
ATC
warfarin; systemic
2.3
18.2
206
1139
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
6.5
18.2
30
48
I66.2
ICD-10 Finland
Occlusion and stenosis of posterior cerebral artery
+∞
17.8
17
*
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
5.0
17.8
39
82
C10AX09
ATC
ezetimibe; oral
2.7
16.9
101
416
C08DB01
ATC
diltiazem; oral
3.1
16.8
79
285
I63.2
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
+∞
16.7
16
*
4019X
ICD-9 Finland
Essential hypertension, Unspecified
3.9
16.7
52
144
C10AA05
ATC
atorvastatin; oral
2.1
16.4
251
1551
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
2.2
16.3
209
1205
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
21.7
16.1
23
11
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.1
15.5
232
1413
R42
ICD-10 Finland
Dizziness and giddiness
2.2
15.4
158
832
C10AA01
ATC
simvastatin; oral
2.0
15.3
307
2078
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.2
14.8
40
100
I66.1
ICD-10 Finland
Occlusion and stenosis of anterior cerebral artery
+∞
14.6
14
*
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
2.8
14.3
76
293
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.3
14.2
125
614
B04AB02, ,
ATC
4.3
13.9
36
87
C09AA02
ATC
enalapril; systemic
2.1
13.7
165
919
4330X
ICD-9 Finland
Occlusion and stenosis of precerebral arteries, Basilar artery[OCCL/STENOS ART.VERTEBRAL.SEU BASILAR.SINE INFARCTU]
+∞
13.6
13
*
I66.4
ICD-10 Finland
Occlusion and stenosis of multiple and bilateral cerebral arteries
+∞
13.6
13
*
PA2VT
NOMESCO Finland
Intravascular evacuation of brain artery embolus
+∞
13.6
13
*
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
+∞
13.6
13
*
C02DE04, ,
ATC
3.5
13.6
48
145
B04AB01, ,
ATC
5.2
13.5
28
56
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.0
13.2
218
1358
5314
FHL
Bypass surgery for four or more vessels
6.1
13.2
23
39
I63.8
ICD-10 Finland
Other cerebral infarction
+∞
12.5
12
*
C08CA01
ATC
amlodipine; oral
1.9
12.0
247
1644
315
Kela drug reimbursment
Clopidogrel
12.1
11.9
21
18
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
2.4
11.9
91
419
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.4
11.8
87
393
41399
ICD-8 Finland
Angina pectoris, Without mention of hypertensive disease
4.9
11.8
26
55
11
HP
Coronary artery bypass surgery
3.6
11.7
39
113
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
+∞
11.5
11
*
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
122.4
11.5
12
*
5651
FHL
Reoperation due to wound complication
122.4
11.5
12
*
4350A
ICD-9 Finland
Transient cerebral ischaemia, Basilar artery syndrome
25.6
11.2
15
6
4409X
ICD-9 Finland
Atherosclerosis, Generalised and unspecified atherosclerosis
25.6
11.2
15
6
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
2.9
11.1
54
198
Z2445
NOMESCO Finland
Psychologist
5.9
11.1
20
35
H53.4
ICD-10 Finland
Visual field defects
9.9
10.8
21
22
SPAT1251
SPAT
Organisation of medication
3.5
10.6
37
111
C01DA14
ATC
isosorbide mononitrate; oral
1.9
10.5
175
1079
C03CA01
ATC
furosemide; systemic
1.8
10.5
282
2014
I67.2
ICD-10 Finland
Cerebral atherosclerosis
112.0
10.5
11
*
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
+∞
10.4
10
*
AAL10
NOMESCO Finland
Intracranial endovascular thrombolysis
+∞
10.4
10
*
I65.3
ICD-10 Finland
Occlusion and stenosis of multiple and bilateral precerebral arteries
+∞
10.4
10
*
PAN14
NOMESCO Finland
Plastic repair of arteries internal carotid artery
+∞
10.4
10
*
AA5PD
NOMESCO Finland
CT examination of brain pefusion
33.2
10.4
13
*
5253
FHL
Cardiac lung machine
5.4
10.2
20
38
4130X
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),MÄÄRITTELEMÄT]
3.3
9.8
38
122
C02DE02, ,
ATC
3.9
9.7
29
78
B01AC06
ATC
acetylsalicylic acid; oral
2.6
9.6
57
232
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.1
9.5
41
140
G46.1*I66.1
ICD-10 Finland
Anterior cerebral artery syndrome
+∞
9.4
9
*
PA6AD
NOMESCO Finland
CT of neck arteries
7.1
9.4
22
32
N18
ICPC
Paralysis/weakness
10.9
9.3
17
16
81
HP
Angiography of the heart and coronary arteries
2.3
9.3
74
346
A10AB05
ATC
insulin aspart; parenteral
2.7
9.3
53
212
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.0
9.1
41
144
C08CA05
ATC
nifedipine; systemic
2.5
9.1
62
270
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.8
9.0
209
1412
R51.80
ICD-10 Finland
Headache
2.4
8.9
64
285
I67.9
ICD-10 Finland
Cerebrovascular disease, unspecified
24.4
8.9
12
5
SPAT1252
SPAT
Overall medication plan or its review
2.5
8.8
59
255
N03AF02
ATC
oxcarbazepine; oral
4.5
8.7
21
48
R47.0
ICD-10 Finland
Dysphasia and aphasia
11.8
8.6
15
13
G45.3
ICD-10 Finland
Amaurosis fugax
6.6
8.6
21
33
4120X
ICD-9 Finland
Old myocardial infarction[STATUS POST INFARCTUM CORDIS,MÄÄRITTELEMÄT]
3.6
8.5
28
81
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.3
8.4
67
313
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
+∞
8.4
8
*
4341A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral embolism
+∞
8.4
8
*
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
+∞
8.4
8
*
C10AA03
ATC
pravastatin; oral
2.5
8.2
55
237
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
3.1
8.2
34
114
4120B
ICD-9 Finland
Old myocardial infarction[STATUS POST INFARCTUM CORDIS,AHTAUTUNUT]
4.2
7.9
21
52
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.8
7.8
132
809
C07AB03
ATC
atenolol; systemic
2.4
7.7
57
257
F01.9
ICD-10 Finland
Vascular dementia, unspecified
3.9
7.6
22
58
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.7
7.5
192
1321
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
81.1
7.4
8
*
K89
ICPC
Transient cerebral ischaemia
9.5
7.3
14
15
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
+∞
7.3
7
*
4349A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral artery occlusion, unspecified[OCCL/STENOS ARTER.CEREBRALES NUD CUM INFARCTU CEREB]
+∞
7.3
7
*
I63
ICD-10 Finland
Cerebral infarction
+∞
7.3
7
*
5315
FHL
Bypass surgery using a mammary artery
3.8
7.3
22
60
I20.00
ICD-10 Finland
Unstable angina
2.9
7.2
34
123
TPX22
NOMESCO Finland
Intravenous arterial thrombolysis
30.4
7.2
9
*
I20.90
ICD-10 Finland
Angina pectoris, unspecified
2.6
7.0
39
154
A06AD11
ATC
lactulose; oral
1.8
7.0
130
818
N06AB04
ATC
citalopram; systemic
1.8
6.9
110
661
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
6.8
105
623
C02LM02, ,
ATC
4.3
6.8
17
40
I70.8
ICD-10 Finland
Atherosclerosis of other arteries
16.9
6.8
10
6
I10
ICD-10 Finland
Essential (primary) hypertension
1.6
6.7
350
2841
C10AA02
ATC
lovastatin; oral
2.6
6.7
39
158
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.1
6.6
65
330
G81.9
ICD-10 Finland
Hemiplegia, unspecified
12.4
6.6
11
9
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
6.5
95
555
C07AA07
ATC
sotalol; systemic
2.4
6.3
42
181
K91
ICPC
Cerebrovascular disease
11.2
6.3
11
10
I50.0
ICD-10 Finland
Congestive heart failure
1.9
6.3
84
476
I20.99
ICD-10 Finland
Angina pectoris, unspecified
2.1
6.3
64
330
G46.4*I67.9
ICD-10 Finland
Cerebellar stroke syndrome
+∞
6.3
6
*
G46.0
ICD-10 Finland
Middle cerebral artery syndrome
+∞
6.3
6
*
4408X
ICD-9 Finland
Atherosclerosis, Of other specified arteries
27.0
6.2
8
*
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.3
6.2
49
228
FNA01
NOMESCO Finland
Anastomosis to coronary artery from internal mammary artery, one distal anastamosis
2.3
6.1
47
216
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.8
6.1
100
604
N02AX02
ATC
tramadol; systemic, rectal
1.6
6.0
231
1734
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
172
1062
1.88
10.24
2.7
1.9
132.16
334.42
u/l
1.87
166
971
55
253
2.30
7.14
2.7
3.1
122.93
126.03
g/l
0.45
55
246
259
2056
1.47
4.90
24.8
19.3
1.47
1.39
inr
0.62
99
579
9
11
8.29
4.57
1.9
1.1
2.46
1.97
mmol/l
—
9
11
65
388
1.76
4.12
3.2
3.4
1.59
2.22
mmol/l
0.67
55
310
67
1024
0.61
3.61
2.4
3.3
0.89
0.85
ug/l
0.09
43
723
9
19
4.79
3.25
3.8
1.6
—
—
—
0
0
348
3888
0.73
3.19
33.8
24.3
38.48
39.07
%
0.63
292
3551
349
3890
0.74
3.08
33.6
24.4
130.81
132.39
g/l
1.05
338
3786
349
3889
0.74
3.07
33.4
24.3
4.36
4.38
e12/l
0.20
335
3731
349
3887
0.74
3.04
33.4
24.3
237.90
235.63
e9/l
0.26
337
3748
110
802
1.46
3.03
6.0
4.0
120.25
256.09
ng/l
1.17
92
695
288
3296
0.75
3.01
22.6
16.0
71.24
71.28
ml/min/173m2
0.01
239
2748
140
1787
0.71
3.01
4.7
5.7
3.44
3.60
ug/l
0.05
127
1543
74
502
1.54
2.88
7.8
5.8
1.18
1.56
mmol/l
0.33
60
386
109
1439
0.70
2.83
4.6
4.8
22.39
21.98
%
0.11
59
763
304
3419
0.76
2.60
6.2
5.0
2.24
2.56
mmol/l
8.99
288
3027
303
3409
0.76
2.60
5.2
4.8
6.21
6.11
mmol/l
0.69
281
3010
59
394
1.55
2.48
3.0
2.6
7.18
6.67
ug/l
0.07
51
336
337
3728
0.77
2.47
12.1
10.3
26.62
24.34
u/l
0.49
322
3545
203
1694
1.31
2.39
2.6
2.7
—
—
—
0
0
6
13
4.65
2.27
1.7
2.2
—
—
—
0
0
298
3320
0.79
2.15
5.6
4.5
4.09
4.42
mmol/l
6.98
282
2963
58
400
1.50
2.13
3.7
3.3
269.38
281.20
ng/l
0.05
50
366
293
3268
0.79
2.12
5.5
4.5
1.33
1.43
mmol/l
3.90
277
2889
5
10
5.03
2.07
1.4
1.0
—
—
—
0
0
47
313
1.55
2.03
1.8
1.6
—
—
—
0
0
96
734
1.37
2.03
1.6
1.6
1.41
1.49
mg/l
0.08
77
581
200
1709
1.26
1.87
6.7
4.2
70.98
70.53
ng/l
0.01
164
1323
6
17
3.55
1.84
1.3
1.1
—
—
—
0
0
45
306
1.51
1.79
4.7
3.6
117.97
93.44
ng/l
0.61
39
269
348
3771
0.80
1.77
28.9
19.9
139.55
139.59
mmol/l
0.09
335
3643
349
3774
0.81
1.70
29.2
20.1
4.02
4.02
mmol/l
0.14
335
3645
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
23
134
1.75
1.68
2.9
2.2
0.41
0.32
u/ml
0.61
12
76
31
467
0.64
1.60
5.7
4.7
32.36
32.78
%
0.07
22
296
7
27
2.61
1.52
1.1
1.4
—
—
—
0
0
7
28
2.52
1.45
1.0
1.0
—
—
—
0
0
37
254
1.49
1.44
1.7
1.4
—
—
—
0
0
6
22
2.74
1.43
1.0
1.1
—
—
—
0
0
5
17
2.96
1.36
1.2
1.1
—
—
—
0
0
9
42
2.16
1.34
2.1
1.1
—
—
—
0
0
290
3155
0.84
1.34
4.9
4.0
1.41
1.24
mmol/l
2.86
273
2763
11
54
2.06
1.33
2.2
6.1
—
159.13
iu/ml
—
0
8
9
172
0.52
1.31
3.3
3.3
39804.00
1792.76
u/ml
—
9
145
64
812
0.76
1.26
2.6
3.2
2.46
2.46
mmol/l
0.01
55
692
336
3597
0.84
1.24
24.4
16.7
26.42
28.19
mg/l
0.48
293
2933
5
19
2.65
1.22
1.0
1.1
—
—
—
0
0
99
1184
0.80
1.21
4.2
3.4
0.67
0.50
e6/l
0.22
80
939
37
266
1.42
1.18
4.4
4.1
3.10
2.28
mmol/l
0.47
30
204
226
2034
1.18
1.17
7.8
6.1
1.20
1.21
mmol/l
0.87
206
1676
118
1366
0.83
1.04
3.0
3.2
2.32
2.34
mmol/l
1.02
101
1172
5
22
2.28
1.03
1.4
1.0
—
—
—
0
0
9
48
1.89
1.01
1.3
1.3
—
—
—
0
0
245
2660
0.86
0.99
4.6
3.8
14.66
15.25
mm/h
0.23
231
2387
118
1018
1.20
0.98
5.0
4.4
0.00
0.00
estimate
-0.00
36
314
73
599
1.25
0.98
2.4
2.4
21.29
22.14
%
0.19
57
516
307
3270
0.87
0.93
7.1
6.3
42.58
41.19
mmol/mol
1.42
287
2944
117
1014
1.19
0.93
3.1
2.8
14497.74
6534.12
umol/l
0.44
101
851
112
967
1.20
0.92
1.7
1.8
1151.85
1182.71
nmol/l
0.14
86
714
8
42
1.92
0.89
2.1
1.8
—
—
—
0
0
111
963
1.19
0.87
1.9
1.8
400.48
7317504.00
pmol/l
0.50
99
779
6
30
2.01
0.87
4.2
1.7
—
—
—
0
0
6
30
2.01
0.87
1.5
1.4
—
68.00
—
0
5
22
153
1.46
0.87
3.6
2.2
—
—
—
0
0
124
1087
1.18
0.87
3.2
2.9
32.41
34.25
u/l
0.25
115
1037
22
155
1.44
0.82
3.2
3.1
4.35
4.31
pmol/l
0.05
22
133
0
24
0.00
0.79
0.0
1.2
—
—
—
0
0
0
24
0.00
0.79
0.0
1.2
—
—
—
0
0
0
24
0.00
0.79
0.0
1.2
—
—
—
0
0
8
48
1.68
0.79
1.1
1.6
—
—
—
0
0
217
2000
1.14
0.77
5.0
5.8
12.72
12.46
umol/l
0.06
212
1888
39
491
0.78
0.77
10.2
8.9
—
—
—
0
0
21
149
1.42
0.76
1.1
1.2
336.43
143.84
iu/ml
—
7
50
10
160
0.62
0.74
2.3
1.7
—
—
—
0
0
5
24
2.09
0.74
1.4
1.0
—
—
—
0
0
15
100
1.51
0.73
1.3
1.3
—
—
—
0
0
15
100
1.51
0.73
1.3
1.3
—
—
—
0
0
14
92
1.53
0.73
1.4
1.3
—
—
—
0
0
154
1695
0.88
0.72
2.3
2.1
95.37
93.41
pmol/l
0.20
90
885
137
1231
1.15
0.71
3.8
3.7
12.63
9.38
mg/mmol
0.37
94
799
7
41
1.72
0.70
1.1
1.8
—
—
—
0
0
5
28
1.79
0.66
1.2
1.1
48.80
55.87
u/l
—
5
23
58
685
0.83
0.66
3.5
3.1
7.14
1.02
e6/l
0.52
36
412
10
62
1.62
0.65
1.1
1.2
—
—
—
0
0
7
44
1.60
0.65
1.1
1.2
—
22.50
—
0
5
12
79
1.53
0.63
1.4
1.7
—
—
—
0
0
301
3162
0.90
0.62
5.0
4.4
1.94
2.03
mu/l
0.62
279
2767
0
21
0.00
0.60
0.0
3.1
—
93.48
—
0
21
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
22
286
0.76
0.58
1.3
1.4
—
—
—
0
0
12
81
1.49
0.57
1.1
1.0
—
7.31
—
0
7
43
357
1.22
0.57
1.7
1.4
—
—
—
0
0
57
661
0.85
0.55
3.6
3.2
4.31
2.09
e6/l
0.48
35
393
9
61
1.48
0.54
1.1
1.1
20.52
34.85
u/l
—
9
51
6
39
1.54
0.53
2.2
2.4
548.50
602.71
ml
—
6
24
192
1795
1.10
0.51
5.0
4.1
0.00
0.00
estimate
-0.00
39
365
99
892
1.13
0.51
2.4
2.4
—
—
—
0
0
154
1425
1.11
0.50
5.5
4.4
—
—
—
0
0
94
1041
0.88
0.49
1.7
1.6
16.76
20.26
nmol/l
2.18
87
870
7
45
1.56
0.49
4.0
4.2
—
—
—
0
0
140
1514
0.90
0.49
4.1
3.4
—
—
—
0
0
191
1790
1.10
0.49
6.8
5.5
0.00
0.00
estimate
-0.00
39
325
23
288
0.79
0.48
1.6
2.8
54.14
56.35
ml/min/173m2
—
7
125
82
740
1.13
0.42
2.0
1.8
—
—
—
0
0
241
2525
0.92
0.42
4.3
3.6
15.20
15.01
pmol/l
0.48
223
2206
67
597
1.14
0.42
1.2
1.2
0.65
1.12
u/ml
1.00
17
129
59
521
1.15
0.42
2.0
1.8
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.7
—
13.65
—
0
16
0
19
0.00
0.39
0.0
1.2
—
170.96
—
0
19
170
1603
1.09
0.38
5.6
5.3
60.05
58.83
%
0.61
156
1483
278
2887
0.93
0.38
7.8
7.2
88.83
81.85
u/l
0.67
264
2671
10
136
0.73
0.38
1.7
1.5
—
—
—
0
0
26
216
1.21
0.37
1.7
1.8
1.80
1.53
g/l
0.69
20
188
58
519
1.13
0.35
2.0
1.7
—
—
—
0
0
40
455
0.87
0.33
5.3
3.9
—
—
—
0
0
13
102
1.28
0.30
1.0
1.2
—
—
—
0
0
42
374
1.13
0.29
2.2
2.0
0.21
0.20
g/l
0.36
37
342
190
1819
1.07
0.28
5.1
4.1
0.00
0.00
estimate
-0.00
37
325
14
112
1.26
0.28
2.7
1.5
—
—
—
0
0
172
1643
1.07
0.28
6.0
5.4
25.11
25.46
%
0.16
157
1522
8
63
1.27
0.28
1.1
1.2
—
—
—
0
0
194
1862
1.06
0.27
7.3
5.2
1.20
1.21
mmol/l
1.74
185
1660
12
95
1.27
0.26
1.2
1.6
—
—
—
0
0
9
73
1.24
0.25
1.1
1.7
—
—
—
0
0
123
1166
1.07
0.25
3.4
3.1
7.31
7.19
mmol/l
0.11
103
953
9
76
1.19
0.24
1.3
2.2
4.36
3.73
g/l
—
9
70
156
1492
1.06
0.24
4.2
3.3
2552.27
2190.04
ng/l
0.28
140
1298
10
126
0.79
0.24
2.1
1.5
—
—
—
0
0
5
39
1.28
0.23
1.0
1.3
—
—
—
0
0
10
79
1.27
0.22
1.7
1.5
—
—
—
0
0
24
273
0.87
0.22
2.0
1.6
—
—
—
0
0
162
1684
0.95
0.22
2.8
2.5
—
—
—
0
0
16
135
1.19
0.21
1.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.9
—
2.72
—
0
5
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
5
43
1.16
0.21
1.2
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
70.97
—
0
14
181
1749
1.05
0.20
5.1
4.5
33.36
34.49
g/l
1.63
169
1605
87
823
1.07
0.20
6.6
4.5
1.02
1.02
kg/l
0.01
25
137
12
99
1.22
0.19
1.7
1.5
201.67
276.74
ug/g
—
6
61
6
51
1.18
0.19
1.5
1.4
—
—
—
0
0
11
132
0.83
0.18
1.8
2.8
14.24
41.64
u/ml
1.85
11
124
7
58
1.21
0.18
1.1
1.7
—
—
—
0
0
292
2979
0.96
0.17
26.2
19.6
15.41
15.48
%
0.07
287
2911
5
67
0.74
0.17
1.6
1.4
42.20
45.61
nmol/l
—
5
62
117
1124
1.05
0.16
2.4
2.1
3.47
3.24
mg/l
0.23
104
935
19
168
1.14
0.16
2.1
3.1
—
—
—
0
0
6
76
0.79
0.15
1.0
1.6
—
—
—
0
0
10
83
1.21
0.15
1.1
1.9
11.64
12.62
mg/l
—
10
75
18
159
1.14
0.15
1.6
1.3
—
35.41
—
0
8
12
102
1.18
0.15
1.0
1.2
—
—
—
0
0
147
1514
0.96
0.14
3.1
2.6
129.86
162.61
ug/l
1.33
140
1354
200
2045
0.97
0.13
7.5
8.0
4.66
4.35
e9/l
0.76
169
1777
11
94
1.17
0.13
1.2
1.6
—
—
—
0
0
17
153
1.11
0.11
1.9
1.6
—
—
—
0
0
83
858
0.96
0.10
1.7
1.6
1.53
1.32
mmol/l
0.52
75
686
5
47
1.06
0.09
1.0
1.7
168.40
247.36
pmol/l
—
5
42
5
60
0.83
0.08
1.0
1.2
—
—
—
0
0
147
1443
1.03
0.07
2.8
2.2
75.93
79.02
nmol/l
0.57
131
1240
19
176
1.08
0.07
2.1
1.8
—
—
—
0
0
199
2018
0.98
0.07
3.9
3.0
67.33
55.56
u/l
0.72
184
1832
15
138
1.09
0.06
1.3
1.2
—
—
—
0
0
9
101
0.89
0.06
1.1
1.4
—
—
—
0
0
49
473
1.04
0.06
1.3
1.3
24.28
35.18
iu/ml
0.57
13
157
44
454
0.97
0.05
1.3
1.3
1.55
11.03
u/ml
2.15
15
157
27
258
1.05
0.05
3.0
2.9
0.11
0.30
e6/l
1.60
27
250
22
210
1.05
0.03
12.6
7.7
24.47
25.00
mmol/l
0.23
22
198
13
134
0.97
0.00
1.1
1.2
—
—
—
0
0
12
119
1.01
0.00
1.2
1.5
—
—
—
0
0
257
2574
1.00
0.00
5.7
5.0
10209.20
2386.43
e6/l
—
5
53
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
2.94
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
5
56
0.89
0.00
1.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
7
0.00
0.00
0.0
5.0
—
108.14
—
0
7
5
54
0.93
-0.00
2.8
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
110.34
—
0
5
6
63
0.95
-0.00
1.2
1.6
—
—
—
0
0
5
51
0.98
-0.00
1.8
1.3
—
—
—
0
0
11
110
1.00
-0.00
1.5
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
8
86
0.93
-0.00
1.8
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
66
0.91
-0.00
1.2
1.6
—
—
—
0
0
6
63
0.95
-0.00
2.7
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
55
0.91
-0.00
1.2
1.5
—
—
—
0
0
5
53
0.94
-0.00
1.0
1.4
—
—
—
0
0
5
55
0.91
-0.00
1.0
1.4
—
—
—
0
0
7
77
0.91
-0.00
9.7
3.5
62.29
60.39
%
—
7
77
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
-0.00
1.4
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
54
0.93
-0.00
1.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
8.55
—
0
8
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
-0.00
0.0
1.2
—
132.67
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint I9_STENOSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_STENOSIS | 1.749 [1.52, 2.02] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.296 |
During the follow-up period (1.1.1998 — 31.12.2019), 656 out of 1237 females with I9_STENOSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_STENOSIS | 1.811 [1.56, 2.1] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 719 out of 1395 males with I9_STENOSIS died.
Mortality risk
Mortality risk for people of age
years, who have I9_STENOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.192% | 0.308% |
| 5 | 1.036% | 2.107% |
| 10 | 2.553% | 5.306% |
| 15 | 4.843% | 9.863% |
| 20 | 8.837% | 16.834% |
Relationships between endpoints
↥Index endpoint: I9_STENOSIS – Occlusion and stenosis of arteries, not leading to stroke
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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