Granulomatosis with Polyangiitis: A small-vessel necrotizing vasculitis characterised by the association of inflammation of the vessel wall and peri- and extravascular granulomatosis.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
571 |
4. Check minimum number of eventsNone |
571 |
5. Include endpointsNone |
571 |
6. Filter based on genotype QC (FinnGen only) |
549 |
Control definitions (FinnGen only)
- Control exclude
- M13_SYSTCONNECT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M31
- Name in latin
- Granulomatosis Wegener
Similar endpoints
↥List of similar endpoints to
Wegener granulomatosis
based on the number of shared cases.
Similar with more cases:
- Other necrotizing vasculopathies (FG)
- Other necrotizing vasculopathies
- Systemic connective tissue disorders
- Autoimmune diseases related-to ILD
- Finngen Rheumatological endpoints
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2962 | 1497 | 1441 |
| Only index persons | 2449 | 1266 | 1183 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 60.38 | 61.29 | 59.32 |
| Only index persons | 59.11 | 60.06 | 58.09 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 549 | 292 | 257 |
| Unadjusted period prevalence (%) | 0.11 | 0.10 | 0.12 |
| Median age at first event (years) | 56.48 | 55.06 | 58.09 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 571
- Matched controls
- 5710
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L04AX01
ATC
azathioprine; systemic
67.0
307.7
289
86
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
34.4
307.7
372
294
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
307.7
493
*
L04AA06
ATC
mycophenolic acid; systemic
77.9
275.4
150
26
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
22.2
247.1
210
146
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
227.8
203
*
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
74.7
209.1
114
19
J99.1*M31.3
ICD-10 Finland
Respiratory disorders in Wegener's granulomatosis
+∞
193.0
174
*
DHA10
NOMESCO Finland
Biopsy of cavity of nose
65.2
167.0
93
17
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
13.9
159.1
170
169
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
9.6
151.5
417
1254
M05BA04
ATC
alendronic acid; oral
11.7
148.8
182
219
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
15.4
136.7
131
108
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
13.1
124.1
132
128
L04AX03
ATC
methotrexate; systemic
9.3
121.2
178
266
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
25.5
120.1
87
40
H02AB06
ATC
prednisolone; systemic
10.2
120.0
480
1944
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
22.9
116.2
88
45
TGC00
NOMESCO Finland
Bronchial lavation
16.8
108.3
96
68
UDH02
NOMESCO Finland
Rhinopharyngoscopy
9.4
106.9
148
204
ZX120
NOMESCO Finland
Intravenous
7.7
98.0
166
287
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
34.7
96.3
62
20
Z94.0
ICD-10 Finland
Kidney transplant status
43.4
91.0
55
14
L01AA01
ATC
cyclophosphamide; systemic
262.9
89.2
89
*
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
83.4
78
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.9
83.3
429
1928
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
12.2
82.5
88
84
KA1AE
NOMESCO Finland
Kidney ultrasound examination
15.5
82.5
75
55
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.4
79.8
135
230
A11CC03
ATC
alfacalcidol; systemic
16.1
78.9
70
49
H02AB04
ATC
methylprednisolone; systemic
5.4
73.3
187
469
A12AA04
ATC
calcium carbonate; oral
20.3
72.6
57
31
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
+∞
68.1
64
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
5.9
64.9
140
300
N18.8
ICD-10 Finland
Other chronic renal failure
14.2
61.4
58
45
N18.0
ICD-10 Finland
End-stage renal disease
29.4
60.7
41
15
127
Kela drug reimbursment
Transplant complication
18.4
59.8
49
29
TK800
NOMESCO Finland
Hemodialysis
14.4
58.7
55
42
Z49.1
ICD-10 Finland
Extracorporeal dialysis
21.6
57.9
44
22
H65.2
ICD-10 Finland
Chronic serous otitis media
18.4
56.3
46
27
R50.9
ICD-10 Finland
Fever, unspecified
4.6
56.3
172
490
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
12.3
55.2
57
51
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
7.1
55.0
91
149
B03XA02
ATC
darbepoetin alfa; parenteral
13.9
54.4
52
41
GD1AD
NOMESCO Finland
Thorax CT examination
6.6
53.2
95
168
1XC02, ,
NOMESCO Finland
72.9
52.3
59
9
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.6
51.5
153
424
L01BA01
ATC
methotrexate; systemic
9.8
50.2
61
69
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
10.8
49.7
56
57
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
20.8
48.0
37
19
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
6.4
46.6
85
153
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
+∞
46.5
44
*
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
13.1
45.8
45
37
TDM10
NOMESCO Finland
Puncture of maxillary antrum
7.5
44.7
68
101
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.5
44.6
130
352
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.5
44.5
230
924
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
8.4
43.7
60
79
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
+∞
43.3
41
*
L04AD01
ATC
ciclosporin; systemic
13.4
41.3
40
32
J31.0
ICD-10 Finland
Chronic rhinitis
4.7
39.7
103
253
H65.3
ICD-10 Finland
Chronic mucoid otitis media
9.9
38.8
46
50
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
7.6
38.4
57
82
M31.7
ICD-10 Finland
Microscopic polyangiitis
+∞
37.9
36
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.3
37.3
198
795
N08.5*M31.7
ICD-10 Finland
Glomerular disease states in microscopic polyangiitis
+∞
36.9
35
*
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
197.4
36.2
37
*
M31.0
ICD-10 Finland
Hypersensitivity angiitis
+∞
35.8
34
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.2
34.2
102
278
UDM02
NOMESCO Finland
Sinoscopy
8.7
33.8
44
54
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
33.7
32
*
M35.3
ICD-10 Finland
Polymyalgia rheumatica
10.4
33.3
38
39
H02AB07
ATC
prednisone; oral
3.6
32.8
129
426
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
5.1
32.5
75
166
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.9
31.6
75
170
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
11.6
31.4
33
30
J34.8
ICD-10 Finland
Other specified disorders of nose and nasal sinuses
12.6
31.0
31
26
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
5.6
30.9
62
121
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
40.6
30.6
38
10
WW200
NOMESCO Finland
Immunization
8.4
30.6
41
52
Z2446
NOMESCO Finland
Social worker
4.6
30.6
79
192
J99.1
ICD-10 Finland
Respiratory disorders in other diffuse connective tissue disorders
+∞
30.5
29
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
62.0
30.4
35
6
N08.5*M31.0
ICD-10 Finland
Glomerular disorders in Goodpasture's syndrome
+∞
28.4
27
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
67.6
28.2
32
5
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
4.1
27.9
84
229
A02BC02
ATC
pantoprazole; systemic
3.1
27.9
445
3063
C03CA01
ATC
furosemide; systemic
2.7
27.8
229
1138
WW400
NOMESCO Finland
Plasmaferesis
+∞
27.3
26
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.7
26.1
51
97
J01MA12
ATC
levofloxacin; systemic
2.9
25.8
154
645
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.0
25.4
141
567
4464A
ICD-9 Finland
Polyarteritis nodosa and allied conditions, Wegener's granulomatosis
+∞
25.2
24
*
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
8.9
25.1
32
38
ZX108
NOMESCO Finland
Inhalation
33.8
24.9
32
10
J01MA14
ATC
moxifloxacin; systemic
3.6
24.7
91
285
DM1BD
NOMESCO Finland
Extensive CT of paranasal sinuses and face area
50.8
24.5
29
6
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
8.3
24.5
33
42
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.7
24.2
178
827
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.3
24.0
67
172
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
4.6
23.9
61
146
137
Kela drug reimbursment
Uraemia requiring dialysis
29.7
23.4
31
11
1AA01, ,
NOMESCO Finland
239.2
22.8
23
*
RD210, ,
NOMESCO Finland
9.1
22.6
28
32
Z49.2
ICD-10 Finland
Other dialysis
47.1
22.5
27
6
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.1
21.0
61
161
Z49.0
ICD-10 Finland
Preparatory care for dialysis
22.5
21.0
30
14
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.5
21.0
79
250
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
21.0
20
*
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
8.1
20.6
28
36
M13.9
ICD-10 Finland
Arthritis, unspecified
3.7
20.6
70
207
WX892
NOMESCO Finland
Monitored bed care
3.6
20.3
74
229
Z2221
NOMESCO Finland
Medical doctor
2.4
20.1
196
1025
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
21.7
20.1
29
14
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.3
20.0
343
2271
R04.2
ICD-10 Finland
Haemoptysis
5.6
19.9
39
74
N08.5*M30.0
ICD-10 Finland
Glomerular disorders in polyarteritis nodosa
+∞
19.9
19
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
17.2
19.8
31
19
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.9
19.8
61
168
Z3231
NOMESCO Finland
Registered nurse
2.4
19.8
199
1055
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
6.3
19.7
34
57
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
7.1
19.7
30
44
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
108.8
19.7
21
*
V03AE02
ATC
sevelamer; oral
72.4
18.8
21
*
P01BA02
ATC
hydroxychloroquine; oral
3.6
18.5
66
201
M05BB03
ATC
alendronic acid and colecalciferol; oral
6.2
18.4
32
54
TPX10
NOMESCO Finland
Implantation of vascular injection port
5.4
18.4
37
72
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.0
18.4
93
351
ZXA10
NOMESCO Finland
Bilateral
2.5
18.3
141
659
M05BA07
ATC
risedronic acid; oral
5.4
17.9
36
70
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
4.0
17.8
54
147
N085, M318,
ICD-10 Finland
+∞
17.8
17
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.2
17.7
75
255
C08CA01
ATC
amlodipine; oral
2.2
17.4
254
1550
L04AD02
ATC
tacrolimus; systemic
16.6
17.2
27
17
R04.0
ICD-10 Finland
Epistaxis
3.3
17.2
69
227
H66.0
ICD-10 Finland
Acute suppurative otitis media
3.4
17.1
65
206
H02AB09
ATC
hydrocortisone; systemic
6.3
17.0
29
48
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
+∞
16.7
16
*
M30.0
ICD-10 Finland
Polyarteritis nodosa
+∞
16.7
16
*
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.2
16.7
187
1024
A02BC01
ATC
omeprazole; systemic
2.2
16.6
189
1042
PAW37
NOMESCO Finland
Biopsy of temporal artery
174.9
16.6
17
*
L88
ICPC
Rheumatoid/seropositive arthritis
4.8
16.6
38
83
XG410
NOMESCO Finland
Flow-volume spirometry
4.4
16.6
43
104
B05DA
ATC
Isotonic solutions
25.3
16.1
22
9
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.1
15.9
34
70
J01FF01
ATC
clindamycin; systemic
2.2
15.9
181
996
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
6.2
15.7
27
45
B03XA01
ATC
erythropoietin; parenteral
15.3
15.5
25
17
V03AE01
ATC
polystyrene sulfonate; oral
15.6
15.0
24
16
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.2
14.9
31
62
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
14.6
14
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.3
14.6
127
622
A41.9
ICD-10 Finland
Sepsis, unspecified
4.5
14.5
36
84
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
4.0
14.4
42
111
RS221, ,
NOMESCO Finland
10.8
14.4
27
26
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.3
14.2
129
643
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.8
14.0
77
302
H26.3
ICD-10 Finland
Drug-induced cataract
18.1
13.9
21
12
R01AD08
ATC
fluticasone; nasal
2.1
13.9
186
1080
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
13.9
173
978
L04AA01
ATC
[U] ciclosporin
14.0
13.8
23
17
B07.9
ICD-10 Finland
Verruca simplex
4.5
13.8
34
79
UDC00
NOMESCO Finland
Ear microscopy
3.0
13.5
65
237
Z3226
NOMESCO Finland
Physiotherapist
2.2
13.4
130
664
H04.10
ICD-10 Finland
Dry eye syndrome
2.7
13.2
80
330
205
Kela drug reimbursment
Chronic hypertension
2.1
13.2
169
962
ZXE00
NOMESCO Finland
One hour or less
1.9
13.2
244
1581
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
3.8
13.1
41
114
H65.0
ICD-10 Finland
Acute serous otitis media
9.7
13.1
26
28
B05DB
ATC
Hypertonic solutions
23.2
13.0
18
8
D64.9
ICD-10 Finland
Anaemia, unspecified
2.7
12.9
74
297
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.0
12.8
61
221
J01MA02
ATC
ciprofloxacin; systemic
1.9
12.8
239
1549
3AC01, ,
NOMESCO Finland
17.8
12.6
19
11
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
+∞
12.5
12
*
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
25.0
12.5
17
7
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
12.4
225
1441
A10AC01
ATC
insulin (human); parenteral
2.8
12.1
64
246
C09AA02
ATC
enalapril; systemic
2.1
11.9
131
701
WX002
NOMESCO Finland
Sedation and analgesia
2.1
11.9
131
702
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.6
11.8
71
291
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
4.9
11.8
26
55
TK810
NOMESCO Finland
Hemofiltration
23.5
11.6
16
7
TK820
NOMESCO Finland
Peritoneal dialysis
23.5
11.6
16
7
J05AB11
ATC
valaciclovir; oral
2.3
11.6
103
506
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
11.5
11
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.7
11.5
68
277
R4110
NOMESCO Finland
Physiotherapy
1.9
11.4
177
1072
R4190
NOMESCO Finland
Nutritional therapy
4.0
11.4
33
87
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
35.8
11.3
14
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
17.5
11.3
17
10
J01CA04
ATC
amoxicillin; systemic
2.2
11.0
472
3934
A12AA12
ATC
[U] calcium acetate
44.2
11.0
13
*
DC1AD
NOMESCO Finland
Temporalbone CT
12.2
10.9
19
16
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
10.9
10.8
20
19
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
5.1
10.8
23
47
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
22.0
10.7
15
7
196
Kela drug reimbursment
Paricalcitol and cinacalcet
22.0
10.7
15
7
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
10.7
246
1680
1CX01, ,
NOMESCO Finland
61.2
10.7
12
*
RS222, ,
NOMESCO Finland
11.5
10.6
19
17
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
5.6
10.5
20
37
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
112.0
10.5
11
*
J05AB01
ATC
aciclovir; systemic
2.0
10.4
138
788
JN4AD
NOMESCO Finland
Body CT examination
2.5
10.3
70
305
ZXD05
NOMESCO Finland
Urgent procedure
1.9
10.2
189
1204
N18.3
ICD-10 Finland
Chronic kidney disease, stage 3
8.7
10.1
21
25
N25.0
ICD-10 Finland
Renal osteodystrophy
40.8
10.0
12
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
17.1
9.9
15
9
R01AD12
ATC
fluticasone furoate; nasal
1.9
9.9
178
1122
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
20.5
9.8
14
7
N19
ICD-10 Finland
Unspecified kidney failure
3.6
9.8
32
92
321
Kela drug reimbursment
Paricalcitol and cinacalcet
13.7
9.7
16
12
DFF00
NOMESCO Finland
Pure tone audiometry
2.4
9.7
72
326
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.4
9.7
68
300
J01DB01
ATC
cefalexin; oral
2.1
9.5
475
4033
6BA02, ,
NOMESCO Finland
30.6
9.4
12
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
9.4
243
1699
M31.2
ICD-10 Finland
Lethal midline granuloma
+∞
9.4
9
*
K65.0
ICD-10 Finland
Acute peritonitis
10.9
9.3
17
16
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
9.7
9.3
18
19
H66.9
ICD-10 Finland
Otitis media, unspecified
2.9
9.0
44
162
ZXE20
NOMESCO Finland
More than three and less than five hours
2.1
9.0
91
469
M81.4
ICD-10 Finland
Drug-induced osteoporosis
19.0
9.0
13
7
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.9
8.8
124
719
ZXA00
NOMESCO Finland
Right side
1.8
8.7
163
1033
B02.9
ICD-10 Finland
Zoster without complication
2.7
8.7
49
194
EB1WA, ,
NOMESCO Finland
14.3
8.7
14
10
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.5
8.7
56
237
TAB00
NOMESCO Finland
Lumbar puncture
3.1
8.7
37
126
M05BA06
ATC
ibandronic acid; systemic
4.9
8.6
19
40
TCC10
NOMESCO Finland
Probing of lacrimal canaliculus/duct
16.6
8.6
13
8
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
28.0
8.5
11
*
V03AE03
ATC
lanthanum carbonate; oral
20.4
8.5
12
6
C08CA13
ATC
lercanidipine; oral
2.1
8.5
89
464
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
4.6
8.4
20
45
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.5
8.3
28
82
RS220, ,
NOMESCO Finland
9.6
8.3
16
17
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.9
8.2
39
141
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.4
8.2
57
250
R01AD09
ATC
mometasone; nasal
1.7
8.2
256
1868
C02CA01
ATC
prazosin; oral
7.0
8.1
19
28
DM1DG
NOMESCO Finland
Paranasal sinuses and face area very extensive MRI examination with high intensity magnet
33.9
8.1
10
*
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
3.7
8.1
25
69
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
3.5
8.0
27
79
J47
ICD-10 Finland
Bronchiectasis
4.4
8.0
20
47
J01AA02
ATC
doxycycline; systemic
1.8
8.0
431
3618
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.1
8.0
81
417
J32.4
ICD-10 Finland
Chronic pansinusitis
6.7
7.9
19
29
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
3.7
7.9
25
70
XX9XE
NOMESCO Finland
Other ultrasound examination
9.6
7.8
15
16
AA1AD
NOMESCO Finland
CT of head and brain
1.8
7.8
159
1030
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.7
7.8
42
163
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
15.3
7.7
12
8
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
15.3
7.7
12
8
D89.80
ICD-10 Finland
Immunoglobulin A (IgA) deposits in organisms
45.6
7.7
9
*
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
45.6
7.7
9
*
C02AC05
ATC
moxonidine; oral
3.0
7.6
34
119
PG5DE
NOMESCO Finland
Ultrasound examination of injection gate to artery or vein with Doppler method
25.4
7.6
10
*
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
3.8
7.5
23
63
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
4.5
7.5
18
41
ZXA05
NOMESCO Finland
Left side
1.8
7.4
147
942
5AB14, ,
NOMESCO Finland
81.1
7.4
8
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.3
7.4
59
275
3025
Kela drug reimbursment
Calcium carbonate
13.6
7.4
12
9
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.0
7.3
87
474
M30.8
ICD-10 Finland
Other conditions related to polyarteritis nodosa
+∞
7.3
7
*
DJA10
NOMESCO Finland
Biopsy of septum of nose
+∞
7.3
7
*
DC1BD
NOMESCO Finland
Temporal bone extensive CT
+∞
7.3
7
*
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
16.0
7.3
11
7
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
3.4
7.2
26
80
R81
ICPC
Pneumonia
3.4
7.2
26
80
306
Kela drug reimbursment
Erythropoietin and darbepoetin
30.4
7.2
9
*
PBM10
NOMESCO Finland
Closure of arteriovenous fistula of radial artery
30.4
7.2
9
*
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
6.7
7.2
17
26
PBL09
NOMESCO Finland
Construction of arteriovenous fistula from brachial artery
20.3
7.2
10
5
K06.18
ICD-10 Finland
Another gingival hyperplasia
20.3
7.2
10
5
H15.1
ICD-10 Finland
Episcleritis
6.2
7.1
18
30
ZX100
NOMESCO Finland
Oral
6.2
7.1
18
30
A07AA02
ATC
nystatin; oral
2.6
7.1
41
165
H05BX01
ATC
cinacalcet; oral
10.2
7.1
13
13
B01AB04
ATC
dalteparin; parenteral
2.8
7.0
36
136
B01AA03
ATC
warfarin; systemic
1.8
7.0
108
641
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
3.1
7.0
28
92
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.5
7.0
44
185
XX6XT
NOMESCO Finland
Other intravascular therapy with radiological guidance
14.0
6.9
11
8
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
14.0
6.9
11
8
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
6.9
211
1515
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
6.8
6.9
16
24
JN4BD
NOMESCO Finland
Extensive body CT
2.1
6.8
66
333
I77.6
ICD-10 Finland
Arteritis, unspecified
40.5
6.8
8
*
TJA33
NOMESCO Finland
Percutaneous introduction of peritoneal dialysis catheter
40.5
6.8
8
*
SPAT1255
SPAT
Intravenous administration of medicine
2.5
6.8
41
169
CCD50
NOMESCO Finland
Dacryocystorhinostomy with insertion of tube
16.9
6.8
10
6
WX730
NOMESCO Finland
Conventional respirator
7.9
6.6
14
18
UKC02
NOMESCO Finland
Cystoscopy
1.9
6.6
91
521
R80
ICD-10 Finland
Isolated proteinuria
12.4
6.6
11
9
H69.0
ICD-10 Finland
Patulous Eustachian tube
12.4
6.6
11
9
D14.0
ICD-10 Finland
Benign neoplasm: Middle ear, nasal cavity and accessory sinuses
7.0
6.6
15
22
A03
ICPC
Fever
1.9
6.5
91
523
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
6.5
252
1905
N30.0
ICD-10 Finland
Acute cystitis
1.9
6.5
87
493
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.2
6.5
56
271
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
6.4
162
1103
M01AE01
ATC
ibuprofen; systemic, rectal
0.6
6.4
404
4564
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
70.6
6.4
7
*
K06.19
ICD-10 Finland
Gingival hyperplasia UNS
14.5
6.4
10
7
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
5.6
6.3
17
31
H15.0
ICD-10 Finland
Scleritis
18.3
6.3
9
5
PG5AC
NOMESCO Finland
Contrast examination of injection gate to artery or vein
+∞
6.3
6
*
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
6.3
6
*
44620
ICD-8 Finland
Polyarteritis nodosa and allied conditions, Other hypersensitivity angiitis
+∞
6.3
6
*
J38.6
ICD-10 Finland
Stenosis of larynx
27.0
6.2
8
*
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
4.0
6.2
17
43
C67.9
ICD-10 Finland
Malignant neoplasm: Bladder, unspecified
5.8
6.2
16
28
WX402
NOMESCO Finland
General anaesthesia
1.7
6.2
116
730
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
7.8
6.1
13
17
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
3.8
6.1
18
48
M95.0
ICD-10 Finland
Acquired deformity of nose
12.7
6.1
10
8
C08CA05
ATC
nifedipine; systemic
2.5
6.1
36
147
I15.0
ICD-10 Finland
Renovascular hypertension
10.2
6.1
11
11
SBB20
NOMESCO Finland
Tooth X-ray examination in conjunction with visit to dentist
6.1
6.0
15
25
WX202
NOMESCO Finland
Supraclavicular plexus blockade
5.6
6.0
16
29
TPH07
NOMESCO Finland
Cathetrisation of artery
2.0
6.0
68
364
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
186
72
37.83
280.53
3.8
1.1
168.61
—
titre
—
79
0
188
95
29.01
256.07
5.1
1.1
13.17
—
iu/ml
—
28
0
89
38
27.56
126.53
4.6
1.1
—
—
u/ml
—
0
0
174
272
8.76
113.55
2.4
1.6
0.76
1.28
g/l
3.59
166
250
309
970
5.76
96.74
7.6
2.5
3.44
5.73
e6/l
1.48
301
877
113
130
10.59
93.35
2.6
1.1
1.21
1.20
g/l
0.09
105
125
114
135
10.30
92.13
1.7
1.5
0.72
0.14
iu/ml
0.52
19
25
94
91
12.17
87.45
6.7
7.7
607.79
359.27
iu/ml
0.37
14
15
399
1685
5.54
83.84
13.3
3.1
—
—
—
0
0
167
352
6.29
79.95
9.2
3.8
120.43
85.35
ng/l
3.30
159
314
381
1657
4.90
74.10
12.9
3.6
38.82
89.06
e6/l
1.27
334
1171
349
1423
4.74
73.91
11.1
3.1
29.32
109.51
e6/l
1.03
328
1092
485
2652
6.50
67.82
22.9
9.3
4.91
4.13
e9/l
6.42
468
2336
393
1835
4.66
67.28
3.6
2.3
80.13
76.98
nmol/l
1.61
388
1642
317
1305
4.21
63.74
11.2
3.0
0.14
0.54
e6/l
4.31
299
983
431
2244
4.76
61.35
12.1
4.9
0.00
0.00
estimate
-0.00
113
424
432
2272
4.70
60.14
8.9
3.6
0.00
0.01
estimate
0.50
111
404
430
2255
4.67
60.07
18.1
6.9
1.22
1.21
mmol/l
0.80
375
1923
428
2253
4.59
59.06
8.9
3.6
0.00
0.00
estimate
0.50
115
451
201
625
4.42
58.92
4.5
2.3
23.00
22.75
%
0.08
181
539
54
42
14.10
57.02
1.8
1.6
—
—
—
0
0
402
2063
4.21
56.52
14.9
6.0
1.22
1.21
mmol/l
0.79
390
1880
69
85
9.10
53.24
1.7
1.5
—
—
—
0
0
199
660
4.09
52.66
4.2
2.3
2.11
2.34
g/l
7.06
193
612
88
146
6.94
52.44
2.9
3.1
—
—
—
0
0
209
721
3.99
52.24
4.2
2.3
11.73
12.97
umol/l
1.93
203
671
74
105
7.95
50.76
1.6
1.3
—
—
—
0
0
304
1372
3.60
50.12
9.7
3.2
379.04
152.01
mg/l
0.52
264
903
96
184
6.07
49.46
3.0
2.1
1.66
1.45
g/l
0.95
84
165
163
489
4.27
49.19
3.4
4.4
256.81
245.71
u/l
0.32
155
464
95
189
5.83
46.97
1.6
2.2
30.94
39.73
u/l
4.41
88
170
56
64
9.59
45.64
1.8
1.6
—
—
—
0
0
306
1463
3.35
44.53
11.7
3.7
15.32
10.06
mg/mmol
1.49
262
927
305
1483
3.27
42.64
10.1
3.0
6.94
7.71
mmol/l
2.64
291
1251
55
68
8.84
42.12
5.5
2.7
4.76
4.51
e9/l
0.23
55
68
53
63
9.17
41.86
1.8
1.6
—
—
—
0
0
70
115
6.80
41.85
4.8
1.3
—
—
—
0
0
156
504
3.88
41.81
3.9
2.7
1.93
1.83
%
0.52
148
458
204
794
3.44
41.04
8.6
2.7
0.33
1.08
e6/l
9.47
159
443
200
769
3.46
41.03
2.3
1.8
—
—
—
0
0
55
72
8.35
40.19
5.7
3.0
60.44
59.11
%
0.21
55
72
158
534
3.71
39.40
2.1
1.8
—
—
—
0
0
68
116
6.52
39.14
2.0
1.7
—
—
—
0
0
66
111
6.59
38.51
2.1
1.7
—
—
—
0
0
156
538
3.61
37.56
2.2
1.8
—
—
—
0
0
53
73
7.90
37.06
1.8
1.5
—
—
—
0
0
130
410
3.81
35.62
2.2
1.9
313.75
380.08
nmol/l
3.74
125
378
135
438
3.73
35.47
9.3
3.8
1.75
1.94
mmol/l
0.29
126
359
50
68
7.96
35.31
2.0
1.6
—
—
—
0
0
497
3448
4.41
35.24
15.8
3.8
14.78
11.83
mm/h
4.26
488
3166
208
890
3.10
34.82
2.1
1.4
2.08
2.47
g/l
2.81
172
540
71
142
5.57
34.58
1.7
1.3
—
—
—
0
0
53
83
6.94
33.00
2.1
1.8
—
—
—
0
0
504
3592
4.44
32.89
19.1
7.6
71.44
79.18
u/l
6.43
499
3365
65
127
5.65
32.42
1.7
2.2
10.03
12.05
mg/l
1.03
58
118
41
50
8.76
31.60
2.0
1.7
—
—
—
0
0
176
753
2.93
28.67
9.5
2.8
1.32
2.33
e6/l
1.96
131
404
31
31
10.52
27.60
2.0
1.5
—
—
—
0
0
40
64
6.65
24.31
1.3
1.1
—
—
—
0
0
229
1200
2.52
24.25
4.5
2.8
356.45
7656.83
umol/l
5.24
221
1054
431
3022
2.74
24.09
8.5
4.4
11579.00
3490.83
e6/l
—
9
48
161
725
2.70
23.18
4.2
3.6
0.82
0.82
mmol/l
0.07
155
687
29
36
8.43
21.94
2.1
1.7
—
—
—
0
0
58
143
4.40
21.87
1.2
2.4
—
—
—
0
0
43
85
5.39
21.04
1.5
1.1
43.00
3.65
u/ml
—
6
8
83
272
3.40
20.87
1.6
1.3
159.86
238.91
u/ml
0.36
78
247
42
82
5.45
20.83
1.8
1.7
—
—
—
0
0
42
82
5.45
20.83
1.8
1.7
—
—
—
0
0
31
18
18.13
20.23
1.3
1.6
—
—
—
0
0
361
2437
2.31
20.15
7.1
6.6
10.19
11.53
umol/l
1.81
355
2316
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
53
131
4.36
19.90
4.2
2.4
0.35
0.31
u/ml
0.29
30
71
28
38
7.70
19.67
2.6
3.2
—
—
—
0
0
50
121
4.43
19.28
1.6
5.0
1.06
2.04
ratio
—
7
16
50
122
4.40
19.07
1.8
5.1
48.66
30.89
mg/l
1.13
40
92
50
122
4.40
19.07
1.8
5.1
63.04
111.93
mg/l
0.40
40
91
37
70
5.58
18.97
1.6
1.1
85.00
5.90
u/ml
—
5
6
40
84
5.05
18.28
2.0
1.4
116.67
101.69
u/ml
—
6
16
209
1167
2.25
18.06
6.6
3.9
96.56
90.80
%
2.60
202
1143
215
1216
2.23
17.99
10.9
3.8
0.00
0.01
estimate
0.50
108
414
254
1540
2.17
17.80
4.4
3.3
2.33
2.35
mmol/l
1.36
242
1361
49
128
4.09
17.08
1.5
1.6
—
—
—
0
0
62
191
3.52
17.08
2.6
1.9
2.49
2.94
ug/l
0.09
56
171
31
55
5.90
16.97
1.8
1.5
—
—
—
0
0
31
55
5.90
16.97
1.8
1.5
—
—
—
0
0
41
95
4.57
16.67
1.3
1.3
—
—
—
0
0
92
364
2.82
16.59
3.6
2.8
58.70
65.44
ml/min/173m2
0.74
47
155
35
72
5.11
16.36
1.1
1.1
—
—
—
0
0
250
1545
2.10
16.30
4.2
3.5
26.49
33.33
u/l
4.67
243
1476
22
10
22.81
15.64
1.3
1.1
—
—
—
0
0
28
25
11.72
15.42
2.1
1.5
—
—
—
0
0
28
26
11.26
15.14
2.1
1.5
—
—
—
0
0
26
45
6.01
14.58
1.1
1.1
—
—
—
0
0
26
23
11.79
14.41
2.6
2.0
—
—
—
0
0
37
89
4.38
14.35
1.4
1.4
293.70
283.26
u/ml
0.05
27
53
291
1984
1.95
13.67
4.6
2.7
188.34
133.83
ug/l
2.08
284
1832
27
52
5.40
13.56
6.1
3.7
—
—
—
0
0
370
2750
1.98
13.32
8.5
4.8
6.63
6.72
mmol/l
0.32
358
2578
139
738
2.17
13.01
1.3
1.2
28.41
35.70
iu/ml
0.67
59
231
174
1007
2.05
12.96
2.6
1.7
2.02
1.25
mg/l
1.70
149
785
262
1752
1.92
12.78
10.2
3.7
—
—
—
0
0
30
69
4.53
12.30
3.0
3.5
1.60
1.56
%
0.02
30
63
188
1138
1.97
12.22
2.8
2.1
3.01
3.10
mg/l
0.26
169
975
99
475
2.31
11.76
3.5
3.3
—
—
—
0
0
70
287
2.64
11.66
6.9
3.7
1.27
1.74
mmol/l
0.52
53
216
67
270
2.68
11.55
1.9
1.6
—
—
—
0
0
211
1358
1.88
11.22
2.5
2.1
113.40
264.48
u/l
1.98
202
1271
36
106
3.56
10.59
1.6
1.5
—
—
—
0
0
129
716
2.04
10.53
1.3
1.2
5.93
12.03
u/ml
0.89
53
270
62
253
2.63
10.41
7.2
2.7
0.04
0.17
e6/l
2.44
62
248
23
49
4.85
10.32
2.1
2.1
—
—
—
0
0
26
62
4.35
10.20
1.1
1.2
3.00
4.00
u/ml
—
6
25
33
94
3.66
10.19
1.5
1.4
—
—
—
0
0
33
94
3.66
10.19
1.5
1.4
—
—
—
0
0
74
335
2.39
9.98
1.5
1.6
—
—
—
0
0
17
14
12.47
9.90
1.8
2.3
—
—
—
0
0
25
60
4.31
9.73
1.1
1.2
6.63
2.94
u/ml
—
8
17
23
52
4.57
9.63
2.1
2.1
—
—
—
0
0
34
106
3.35
9.18
1.4
1.3
—
—
—
0
0
100
534
2.06
8.97
11.9
8.0
0.87
1.19
mmol/l
0.36
81
427
524
4663
2.50
8.74
42.0
14.0
19.26
24.10
mg/l
4.58
499
3689
295
2207
1.70
8.73
18.3
14.1
1.16
1.24
inr
1.02
97
652
30
92
3.39
8.32
3.9
2.3
15.81
16.23
%
0.17
14
47
33
108
3.18
8.26
1.1
1.1
—
—
—
0
0
469
4073
1.85
7.31
44.6
17.0
14.72
14.91
%
0.42
469
4015
11
7
15.98
7.25
2.3
1.1
87.55
89.57
%
—
11
7
135
859
1.75
6.95
2.8
2.9
2.47
2.45
mmol/l
1.11
123
756
11
8
13.99
6.91
2.0
1.5
—
—
—
0
0
14
17
8.41
6.86
2.4
5.9
—
—
—
0
0
79
437
1.94
6.35
2.0
2.4
35.78
31.63
u/l
0.62
73
368
17
31
5.62
6.34
1.8
1.1
—
—
—
0
0
20
57
3.60
6.21
1.8
1.7
87.27
89.82
%
0.59
20
57
10
8
12.69
6.10
1.6
2.0
—
—
—
0
0
16
29
5.65
6.03
1.0
1.0
—
—
—
0
0
18
49
3.76
5.96
1.7
1.8
—
—
—
0
0
18
49
3.76
5.96
1.7
1.8
—
—
—
0
0
18
49
3.76
5.96
1.7
1.8
—
—
—
0
0
17
34
5.12
5.91
1.5
1.1
—
—
—
0
0
17
34
5.12
5.91
1.5
1.1
—
—
—
0
0
30
114
2.72
5.83
1.4
1.3
527.97
468.80
mg/l
0.45
30
107
10
9
11.28
5.81
1.1
1.0
—
—
—
0
0
18
50
3.68
5.80
1.5
1.3
42.00
71.50
%
—
10
40
17
35
4.97
5.78
1.5
1.1
—
—
—
0
0
17
35
4.97
5.78
1.5
1.1
—
—
—
0
0
17
35
4.97
5.78
1.5
1.1
—
—
—
0
0
17
36
4.83
5.65
1.2
1.2
0.43
0.51
u/ml
—
10
21
17
36
4.83
5.65
1.4
1.2
—
—
—
0
0
67
365
1.95
5.63
3.3
3.3
106.98
210.93
ng/l
2.94
62
332
27
99
2.81
5.61
1.4
1.2
11.86
8.10
e6/l
0.21
22
78
16
32
5.11
5.60
3.1
2.5
47.50
38.70
%
—
8
18
16
32
5.11
5.60
2.8
3.1
—
—
—
0
0
8
5
16.20
5.42
1.0
1.0
—
—
—
0
0
14
25
5.71
5.40
1.0
1.2
1.96
2.01
mmol/l
0.09
14
25
16
43
3.80
5.40
1.6
1.4
—
—
—
0
0
126
842
1.64
5.29
1.8
1.7
1176.39
1202.12
nmol/l
0.10
110
645
20
67
3.06
4.87
9.8
6.3
13.37
10.97
mg/l
1.47
20
61
9
10
9.12
4.80
1.3
1.5
—
—
—
0
0
13
25
5.30
4.79
1.1
1.1
—
—
—
0
0
13
25
5.30
4.79
1.5
1.3
—
—
—
0
0
28
116
2.49
4.62
2.2
1.6
12915.82
18639.67
e6/l
0.27
22
85
237
1867
1.46
4.58
2.0
2.0
94.48
95.19
pmol/l
0.08
134
971
26
105
2.55
4.52
3.7
2.0
123.47
130.76
g/l
0.73
17
78
180
1346
1.49
4.52
3.2
3.0
1523.42
1278.18
ng/l
0.33
167
1149
152
1098
1.52
4.50
1.6
1.5
17.81
20.87
nmol/l
2.36
145
936
29
124
2.41
4.49
1.8
1.3
—
—
—
0
0
520
4826
1.87
4.44
38.3
16.3
139.68
139.70
mmol/l
0.08
515
4704
521
4844
1.86
4.34
39.0
16.4
3.98
3.98
mmol/l
0.02
516
4710
18
61
3.01
4.32
1.2
1.1
—
—
—
0
0
15
39
3.92
4.22
2.1
2.3
—
—
—
0
0
139
1000
1.52
4.17
10.3
3.8
1.02
1.02
kg/l
0.23
12
144
270
2212
1.42
4.09
3.3
2.6
—
—
—
0
0
26
111
2.41
4.05
1.5
3.8
25.58
35.62
umol/l
3.46
26
101
17
58
2.99
4.04
2.6
2.0
32.18
33.10
pg
0.34
17
58
7
7
10.10
4.02
1.0
1.0
—
—
—
0
0
28
126
2.29
3.89
1.5
1.4
166.24
235.23
miu/ml
—
7
61
127
917
1.50
3.71
4.3
3.9
172.00
308.13
ng/l
0.80
107
720
17
405
0.40
3.59
1.1
1.7
—
—
—
0
0
49
284
1.79
3.45
1.5
1.4
—
—
—
0
0
149
1126
1.44
3.42
3.5
2.3
—
—
—
0
0
11
27
4.13
3.41
1.7
1.9
—
—
—
0
0
11
27
4.13
3.41
1.7
1.9
—
—
—
0
0
9
18
5.06
3.38
1.0
1.3
—
—
—
0
0
35
187
1.93
3.18
2.3
1.9
—
—
—
0
0
220
1803
1.36
3.08
4.3
3.6
38.18
59.55
ng/l
0.49
173
1263
17
68
2.55
3.07
1.1
1.3
—
—
—
0
0
477
4430
1.47
2.91
34.0
13.0
71.26
81.15
ml/min/173m2
12.10
445
3653
163
1284
1.38
2.90
2.0
1.6
1.39
1.39
mmol/l
0.02
147
1090
9
22
4.14
2.89
1.1
1.2
—
—
—
0
0
9
22
4.14
2.89
1.1
1.2
—
—
—
0
0
78
537
1.52
2.84
2.7
3.1
6.75
9.93
umol/l
1.17
67
477
180
1447
1.36
2.81
2.8
2.6
183.08
59.75
u/l
0.50
174
1342
467
4330
1.43
2.78
6.9
5.8
39.42
39.92
mmol/mol
0.30
453
4034
14
55
2.58
2.63
1.3
1.2
—
—
—
0
0
8
20
4.04
2.57
2.0
2.2
—
—
—
0
0
8
20
4.04
2.57
2.0
2.2
—
—
—
0
0
8
20
4.04
2.57
2.0
2.2
—
—
—
0
0
12
44
2.76
2.56
4.6
2.2
—
—
—
0
0
19
92
2.10
2.29
2.6
1.6
—
—
—
0
0
6
13
4.65
2.27
2.2
1.1
—
—
—
0
0
7
18
3.92
2.26
1.0
1.1
—
—
—
0
0
5
9
5.59
2.21
1.2
1.0
1334.00
1212.33
miu/ml
—
5
9
8
24
3.37
2.18
1.1
1.3
—
—
—
0
0
8
24
3.37
2.18
1.0
1.0
—
—
—
0
0
30
174
1.76
2.18
2.1
1.7
—
—
—
0
0
6
14
4.32
2.15
2.2
1.1
—
—
—
0
0
428
4555
0.76
2.10
5.6
4.5
5.73
5.99
mmol/l
3.73
407
4175
5
10
5.03
2.07
1.0
1.0
—
—
—
0
0
7
20
3.53
2.06
1.6
1.3
—
—
—
0
0
9
32
2.84
2.01
1.3
1.2
—
—
—
0
0
7
21
3.36
1.97
1.4
1.0
414.29
199.60
iu/ml
—
7
21
14
64
2.22
1.96
1.0
1.1
—
—
—
0
0
5
11
4.57
1.94
1.0
1.4
—
—
—
0
0
5
11
4.57
1.94
1.2
1.0
—
—
—
0
0
5
11
4.57
1.94
1.0
1.4
—
—
—
0
0
8
27
2.99
1.94
1.0
1.1
—
—
—
0
0
12
54
2.25
1.75
1.0
1.1
—
—
—
0
0
7
24
2.94
1.72
1.0
1.1
—
—
—
0
0
11
228
0.47
1.72
1.0
1.0
—
—
—
0
0
10
44
2.29
1.56
1.2
1.0
—
—
—
0
0
316
2891
1.21
1.45
3.2
3.0
—
—
—
0
0
11
52
2.14
1.45
1.0
1.1
—
—
—
0
0
5
16
3.14
1.44
1.0
1.3
—
—
—
0
0
9
42
2.16
1.34
1.1
1.0
—
—
—
0
0
5
18
2.79
1.28
11.4
3.3
—
—
—
0
0
5
18
2.79
1.28
11.4
3.3
—
—
—
0
0
8
35
2.30
1.27
1.1
1.4
78.38
75.23
umol/l
—
8
35
115
963
1.24
1.26
1.5
1.7
101887222.43
432.09
pmol/l
0.75
106
803
44
590
0.72
1.25
1.3
1.7
1.56
1.48
%
0.26
38
527
6
25
2.41
1.24
2.7
4.2
108.00
99.08
%
—
6
25
11
201
0.54
1.23
1.6
1.8
—
—
—
0
0
23
148
1.58
1.22
1.3
1.1
—
—
—
0
0
5
20
2.51
1.15
1.0
1.0
—
—
—
0
0
51
390
1.34
1.13
2.1
2.4
4.80
6.53
ug/l
0.49
41
348
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
30
2.35
1.12
1.0
1.2
—
—
—
0
0
21
137
1.55
1.07
1.3
1.2
—
—
—
0
0
7
33
2.13
1.06
2.0
1.3
—
—
—
0
0
7
33
2.13
1.06
2.1
1.8
—
—
—
0
0
7
33
2.13
1.06
2.0
1.3
—
—
—
0
0
26
181
1.46
1.00
6.5
4.0
1.26
1.38
mmol/l
0.46
26
176
21
141
1.51
0.96
2.4
1.7
—
—
—
0
0
77
920
0.81
0.94
2.5
3.0
0.71
0.76
ug/l
0.29
60
605
35
454
0.76
0.85
1.7
2.0
—
—
—
0
0
16
237
0.67
0.83
2.4
3.0
37.19
54.12
u/ml
0.43
16
227
21
146
1.46
0.83
1.2
1.1
—
—
—
0
0
11
65
1.71
0.83
2.2
1.6
—
—
—
0
0
0
27
0.00
0.77
0.0
1.3
—
—
—
0
0
530
5198
1.27
0.76
54.0
20.8
39.34
40.32
%
3.78
499
4861
530
5199
1.27
0.75
53.1
20.8
263.71
247.31
e9/l
6.30
525
5076
530
5203
1.26
0.71
53.1
20.8
4.34
4.51
e12/l
11.00
523
5069
5
26
1.93
0.70
1.2
1.5
1.40
1.61
u/field
—
5
17
17
118
1.45
0.70
2.8
2.3
19878.80
4452.15
u/l
—
6
45
19
135
1.42
0.70
1.3
1.3
—
—
—
0
0
40
494
0.80
0.69
1.7
2.1
—
—
—
0
0
530
5206
1.25
0.68
53.4
20.9
130.18
135.88
g/l
14.15
525
5130
91
799
1.17
0.64
1.7
1.5
—
—
—
0
0
6
104
0.57
0.62
1.5
1.5
—
—
—
0
0
5
30
1.67
0.61
1.6
1.3
—
—
—
0
0
5
30
1.67
0.61
1.6
1.3
—
—
—
0
0
15
105
1.44
0.60
1.6
1.6
5.33
7.12
iu/l
—
6
30
114
1262
0.88
0.58
3.6
4.3
22.45
21.37
%
0.35
58
598
8
54
1.49
0.57
1.3
1.5
—
—
—
0
0
366
3520
1.11
0.57
4.2
3.8
15.05
14.81
pmol/l
0.98
337
3178
5
86
0.58
0.56
2.0
1.8
—
—
—
0
0
6
97
0.61
0.52
1.5
1.4
—
—
—
0
0
6
97
0.61
0.52
1.5
1.4
—
—
—
0
0
6
97
0.61
0.52
1.5
1.4
—
—
—
0
0
14
102
1.38
0.47
4.4
4.0
25.43
31.15
mg/l
—
7
64
7
47
1.50
0.47
1.1
1.1
—
—
—
0
0
462
4715
0.89
0.46
5.5
4.9
2.67
2.75
mmol/l
1.13
441
4360
9
127
0.70
0.44
1.2
1.4
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
8
61
1.32
0.39
2.0
1.6
—
—
—
0
0
8
61
1.32
0.39
2.0
1.6
—
—
—
0
0
8
61
1.32
0.39
2.0
1.6
—
—
—
0
0
43
493
0.86
0.39
3.0
4.1
9.00
36.87
ug/l
0.90
35
416
149
1581
0.92
0.35
4.1
4.8
2.52
2.46
ug/l
0.06
133
1423
436
4442
0.92
0.33
4.6
4.0
1.37
1.29
mmol/l
1.49
416
4084
50
558
0.89
0.32
12.8
6.9
—
—
—
0
0
7
100
0.70
0.31
2.1
2.0
187.14
229.20
pmol/l
—
7
93
60
653
0.91
0.26
1.4
1.4
—
—
—
0
0
5
72
0.69
0.26
1.0
1.3
7.64
7.28
mmol/l
—
5
61
5
72
0.69
0.26
1.0
1.1
—
21.67
—
0
15
28
245
1.15
0.25
1.3
1.2
—
—
—
0
0
5
41
1.22
0.22
1.6
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
22
251
0.87
0.21
1.7
1.8
—
—
—
0
0
15
128
1.18
0.18
1.2
1.2
—
—
—
0
0
455
4599
0.95
0.18
5.1
4.4
1.53
1.45
mmol/l
2.74
434
4255
7
59
1.19
0.18
2.0
1.4
0.35
0.38
nmol/l
—
7
47
7
61
1.15
0.17
2.0
1.6
—
—
—
0
0
7
61
1.15
0.17
2.0
1.6
—
—
—
0
0
7
62
1.13
0.17
2.0
1.6
—
—
—
0
0
423
4274
0.96
0.14
4.9
4.6
1.93
2.19
mu/l
0.42
396
3902
15
170
0.88
0.14
1.5
1.5
—
—
—
0
0
8
100
0.80
0.13
2.1
1.7
—
—
—
0
0
318
3134
1.03
0.13
3.8
3.2
59.96
49.31
u/l
0.43
307
2935
15
168
0.89
0.12
2.5
1.7
—
—
—
0
0
460
4626
0.97
0.08
5.2
4.5
4.66
4.64
mmol/l
0.21
438
4306
55
569
0.96
0.07
4.3
4.6
32.81
31.60
%
0.43
47
387
105
1032
1.02
0.05
1.2
1.2
0.63
1.23
u/ml
1.54
23
281
12
112
1.07
0.03
1.7
1.5
—
—
—
0
0
30
294
1.02
0.00
1.4
1.2
262.50
161.81
iu/ml
0.34
11
115
13
134
0.97
0.00
1.8
1.5
280.13
287.86
ug/g
—
8
75
5
57
0.88
0.00
1.0
1.1
1.54
1.49
g/l
—
5
52
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
8
79
1.01
-0.00
1.4
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_WEGENER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_WEGENER | 2.443 [2.07, 2.88] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.026 |
During the follow-up period (1.1.1998 — 31.12.2019), 351 out of 1165 females with M13_WEGENER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_WEGENER | 2.398 [2.01, 2.86] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 368 out of 1088 males with M13_WEGENER died.
Mortality risk
Mortality risk for people of age
years, who have M13_WEGENER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.245% | 0.406% |
| 5 | 1.471% | 2.311% |
| 10 | 3.471% | 6.235% |
| 15 | 6.26% | 11.394% |
| 20 | 10.164% | 18.006% |
Relationships between endpoints
↥Index endpoint: M13_WEGENER – Wegener granulomatosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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