placenta disease: a disease located in the placenta
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
349 |
4. Check minimum number of eventsNone |
349 |
5. Include endpointsNone |
349 |
6. Filter based on genotype QC (FinnGen only) |
349 |
Control definitions (FinnGen only)
- Control exclude
- O15_MATERN_CARE
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF3
- Parent code in ICD-10
- O30-O48
- Name in latin
- Morbositates placentae
Similar endpoints
↥List of similar endpoints to
Placental disorders
based on the number of shared cases.
Similar with more cases:
- Maternal care related to the fetus and amniotic cavity and possible delivery problems
- Delivery, wide proxy
- Pregnancy, childbirth and the puerperium
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2428 | 2428 | - |
| Only index persons | 2399 | 2399 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.07 | - |
| Only index persons | 0.09 | 0.09 | - |
| Median age at first event (years) | |||
| Whole population | - | 31.60 | - |
| Only index persons | - | 31.60 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 349 | 349 | - |
| Unadjusted period prevalence (%) | 0.12 | 0.12 | - |
| Median age at first event (years) | 31.71 | 31.71 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 306
- Matched controls
- 3059
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O43.8
ICD-10 Finland
Other placental disorders
+∞
117.5
105
*
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
30.3
106.8
150
94
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
+∞
90.2
82
*
O36.5
ICD-10 Finland
Maternal care for poor fetal growth
365.1
60.6
59
*
O43.0
ICD-10 Finland
Placental transfusion syndromes
+∞
56.0
52
*
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
12.6
54.1
105
122
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
20.0
52.9
82
55
O43.9
ICD-10 Finland
Placental disorder, unspecified
+∞
49.3
46
*
O82.0
ICD-10 Finland
Delivery by elective caesarean section
48.3
49.1
59
15
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
17.1
46.9
77
59
O32.1
ICD-10 Finland
Maternal care for breech presentation
+∞
46.0
43
*
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
8.4
42.5
105
179
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
6.1
42.4
148
409
Z39.2
ICD-10 Finland
Routine postpartum follow-up
6.1
41.3
142
382
O60
ICD-10 Finland
Preterm labour and delivery
24.4
37.3
53
26
O43.2
ICD-10 Finland
Morbidly adherent placenta
+∞
37.2
35
*
O35.8
ICD-10 Finland
Maternal care for other (suspected) fetal abnormality and damage
+∞
37.2
35
*
O30.0
ICD-10 Finland
Twin pregnancy
+∞
35.1
33
*
O42.9
ICD-10 Finland
Premature rupture of membranes, unspecified
372.5
33.6
33
*
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
4.5
31.0
144
502
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
4.0
28.2
173
756
6567A
ICD-9 Finland
Other foetal and placental problems affecting management of mother, Other placental conditions[CONDITIO PLACENTAE ALIA, RASKAUDEN AIKANA]
+∞
26.4
25
*
SPAT1379
SPAT
Health check-up of pregnant person
4.4
24.8
108
339
O44.0
ICD-10 Finland
Placenta praevia specified as without haemorrhage
+∞
24.3
23
*
Z87.5
ICD-10 Finland
Personal history of complications of pregnancy, childbirth and the puerperium
94.5
24.1
26
*
O36.6
ICD-10 Finland
Maternal care for excessive fetal growth
259.5
24.0
24
*
O46.9
ICD-10 Finland
Antepartum haemorrhage, unspecified
+∞
23.2
22
*
ZXD05
NOMESCO Finland
Urgent procedure
3.5
22.4
140
588
WX320
NOMESCO Finland
Spinalanesthesy
4.5
22.3
90
258
MAA00
NOMESCO Finland
Amniocentesis
22.8
21.7
31
15
W78
ICPC
Pregnancy
3.6
21.5
125
493
O35.1
ICD-10 Finland
Maternal care for (suspected) chromosomal abnormality in fetus
+∞
21.1
20
*
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
3.8
20.8
109
393
SPAT1380
SPAT
Postpartum check-up
4.2
20.8
90
274
O41.0
ICD-10 Finland
Oligohydramnios
+∞
20.0
19
*
6567B
ICD-9 Finland
Other foetal and placental problems affecting management of mother, Other placental conditions[CONDITIO PLACENTAE ALIA, SYNNYTYKSEN AIKANA]
+∞
20.0
19
*
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
19.4
20.0
30
17
W84
ICPC
Pregnancy high risk
8.5
19.8
44
59
SPAT1317
SPAT
Planned health check-up monitoring, health check-up performed based on individual need
4.0
18.5
83
258
Z32.1
ICD-10 Finland
Pregnancy confirmed
3.9
18.5
87
282
SPAT1197
SPAT
Extensive health check-up of expecting family
3.4
17.9
105
403
O44.1
ICD-10 Finland
Placenta praevia with haemorrhage
+∞
17.9
17
*
O48
ICD-10 Finland
Prolonged pregnancy
+∞
17.9
17
*
O43.1
ICD-10 Finland
Malformation of placenta
+∞
17.9
17
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
4.7
17.1
62
156
O30.01
ICD-10 Finland
Twin pregnancy with a shared chorionic sac and a separate amniotic sac
+∞
16.8
16
*
O40
ICD-10 Finland
Polyhydramnios
+∞
15.8
15
*
MA2XE
NOMESCO Finland
Other obstetric ultrasound examination
4.6
15.3
56
142
O72.0
ICD-10 Finland
Third-stage haemorrhage
10.0
15.1
30
33
O47.1
ICD-10 Finland
False labour at or after 37 completed weeks of gestation
+∞
14.7
14
*
6560B
ICD-9 Finland
Other foetal and placental problems affecting management of mother, Foetal-maternal haemorrhage[TRANSFUSIO FOETO-MATERNALIS, SYNNYTYKSEN AIKANA]
+∞
14.7
14
*
O36.4
ICD-10 Finland
Maternal care for intrauterine death
+∞
14.7
14
*
O36.3
ICD-10 Finland
Maternal care for signs of fetal hypoxia
+∞
13.6
13
*
O36.8
ICD-10 Finland
Maternal care for other specified fetal problems
+∞
13.6
13
*
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
7.5
13.3
31
45
SPAT1196
SPAT
Monitoring of normal pregnancy
3.8
13.2
60
185
O72.2
ICD-10 Finland
Delayed and secondary postpartum haemorrhage
14.9
13.0
21
15
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
3.6
12.8
61
196
O35.9
ICD-10 Finland
Maternal care for (suspected) fetal abnormality and damage, unspecified
+∞
12.6
12
*
FM1NE
NOMESCO Finland
Ultrasound examination of fetal heart
+∞
12.6
12
*
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
3.1
12.2
74
283
8811
FHL
Cesarean section
5.1
11.9
38
83
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
2.9
11.6
78
319
O42.0
ICD-10 Finland
Premature rupture of membranes, onset of labour within 24 hours
+∞
11.5
11
*
MBA30
NOMESCO Finland
Manual removal of placenta from delivered uterus
11.2
11.5
21
20
WX307
NOMESCO Finland
Obstetric epidural analgesia
3.2
11.3
66
245
O20.9
ICD-10 Finland
Haemorrhage in early pregnancy, unspecified
6.0
11.1
30
54
O47.9
ICD-10 Finland
False labour, unspecified
29.2
10.8
14
5
O41.1
ICD-10 Finland
Infection of amniotic sac and membranes
+∞
10.5
10
*
O46.8
ICD-10 Finland
Other antepartum haemorrhage
+∞
10.5
10
*
TMW99
NOMESCO Finland
Other minor surgical procedure in obstetrics
16.8
10.5
16
10
FM1QE
NOMESCO Finland
Extensive ultrasound of fetal heart
33.8
10.4
13
*
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.8
10.1
71
298
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
5.3
9.9
30
62
Z34.9
ICD-10 Finland
Supervision of normal pregnancy, unspecified
2.8
9.9
70
294
WX306
NOMESCO Finland
Lumbar epidural anesthesy
3.5
9.8
47
151
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
9.6
9.7
19
21
ZXE00
NOMESCO Finland
One hour or less
2.2
9.5
137
828
O31.8
ICD-10 Finland
Other complications specific to multiple gestation
+∞
9.4
9
*
O34.1
ICD-10 Finland
Maternal care for tumour of corpus uteri
+∞
9.4
9
*
Z36.0
ICD-10 Finland
Antenatal screening for chromosomal anomalies
3.9
9.4
39
111
O28.3
ICD-10 Finland
Abnormal ultrasonic finding on antenatal screening of mother
19.3
9.0
13
7
O64.1
ICD-10 Finland
Obstructed labour due to breech presentation
24.9
9.0
12
5
O02.1
ICD-10 Finland
Missed abortion
3.5
8.9
42
133
MBB10
NOMESCO Finland
Packing of delivered uterus
51.5
8.7
10
*
O84.0
ICD-10 Finland
Multiple delivery, all spontaneous
92.5
8.5
9
*
O99.80
ICD-10 Finland
The fear of childbirth
4.0
8.4
33
90
O34.3
ICD-10 Finland
Maternal care for cervical incompetence
+∞
8.4
8
*
O84.2
ICD-10 Finland
Multiple delivery, all by caesarean section
+∞
8.4
8
*
O80.0
ICD-10 Finland
Spontaneous vertex delivery
2.0
8.2
151
994
Z31.5
ICD-10 Finland
Genetic counselling
3.8
7.8
32
91
O80.8
ICD-10 Finland
Other single spontaneous delivery
4.5
7.6
26
62
B01AB05
ATC
enoxaparin; parenteral
2.3
7.5
75
376
PC7NT
NOMESCO Finland
Endovascular occlusion of uteral arteries to stop puerperal bleeding
82.0
7.4
8
*
MAB20
NOMESCO Finland
Failed external version
82.0
7.4
8
*
MA4AT
NOMESCO Finland
Chorion biopsy with ultrasound guidance
82.0
7.4
8
*
MA2BG
NOMESCO Finland
Fetal examination with high intensity magnet
+∞
7.3
7
*
O35.0
ICD-10 Finland
Maternal care for (suspected) central nervous system malformation in fetus
+∞
7.3
7
*
O31.2
ICD-10 Finland
Continuing pregnancy after intrauterine death of one fetus or more
+∞
7.3
7
*
O20.8
ICD-10 Finland
Other haemorrhage in early pregnancy
16.2
7.3
11
7
MA3AE
NOMESCO Finland
Combined first trimester screening
3.3
7.3
36
119
TPH07
NOMESCO Finland
Cathetrisation of artery
3.8
7.1
29
82
O72.1
ICD-10 Finland
Other immediate postpartum haemorrhage
5.7
7.0
19
35
O68.0
ICD-10 Finland
Labour and delivery complicated by fetal heart rate anomaly
3.4
6.8
32
102
Z34
ICD-10 Finland
Supervision of normal pregnancy
3.2
6.8
35
120
MA5AE
NOMESCO Finland
Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation
3.2
6.8
35
120
O10.0
ICD-10 Finland
Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium
6.7
6.7
16
25
O26.82
ICD-10 Finland
Exhaustion and fatigue pregnancy-related
6.7
6.7
16
25
O73.0
ICD-10 Finland
Retained placenta without haemorrhage
12.6
6.6
11
9
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
5.9
6.6
17
30
W92
ICPC
Compl labour/ delivery livebirth
5.9
6.6
17
30
XMA22
NOMESCO Finland
General examination of pregnant woman
3.3
6.5
31
100
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.9
6.5
140
948
W90
ICPC
Uncompl labour/delivery livebirth
3.2
6.4
32
107
SPAT1357
SPAT
Monitoring of problem during pregnancy
4.5
6.4
21
49
6440B
ICD-9 Finland
Early or threatened labour, Threatened premature labour[PARTUS PRAEMATURUS]
11.4
6.3
11
10
O61.0
ICD-10 Finland
Failed medical induction of labour
11.4
6.3
11
10
O32.2
ICD-10 Finland
Maternal care for transverse and oblique lie
+∞
6.3
6
*
O36.9
ICD-10 Finland
Maternal care for fetal problem, unspecified
+∞
6.3
6
*
MAA54
NOMESCO Finland
Fetoscopy
+∞
6.3
6
*
MAA06
NOMESCO Finland
Amnioreduction
+∞
6.3
6
*
O30.00
ICD-10 Finland
Twin pregnancy with separate amniotic and chorionic sacs
+∞
6.3
6
*
NE1AG
NOMESCO Finland
MRI pelvimetry with high intensity magnet
+∞
6.3
6
*
W85
ICPC
Gestational diabetes
3.6
6.2
27
81
Z34.0
ICD-10 Finland
Supervision of normal first pregnancy
2.1
6.1
79
439
O47
ICD-10 Finland
False labour
12.9
6.1
10
8
O63.0
ICD-10 Finland
Prolonged first stage (of labour)
6.9
6.1
14
21
WW500
NOMESCO Finland
Blood transfusion
5.0
6.0
18
38
Mortality – FinRegistry
↥Association
Association between endpoint O15_PLAC_DISORD and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have O15_PLAC_DISORD.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: O15_PLAC_DISORD – Placental disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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