No definition available.
Other drug-induced secondary parkinsonism
OTHER_DRUGADVERS_SECONDA_PARKINSONI
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
309 |
4. Check minimum number of eventsNone |
309 |
5. Include endpointsNone |
309 |
6. Filter based on genotype QC (FinnGen only) |
309 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Other drug-induced secondary parkinsonism
based on the number of shared cases.
Similar with more cases:
- Secondary parkinsonism, excluding more controls
- Secondary parkinsonism
- Secondary parkinsonism+Parkinsonism in other disease
- Extrapyramidal and movement disorders
- Neurological diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2777 | 1626 | 1117 |
| Only index persons | 2288 | 1355 | 933 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.03 |
| Only index persons | 0.04 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 68.05 | 69.66 | 65.61 |
| Only index persons | 67.29 | 68.87 | 64.99 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 309 | 152 | 157 |
| Unadjusted period prevalence (%) | 0.06 | 0.05 | 0.07 |
| Median age at first event (years) | 62.79 | 63.20 | 62.40 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 286
- Matched controls
- 2859
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G21.1
ICD-10 Finland
Other drug-induced secondary parkinsonism
+∞
323.0
286
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
92.4
195.4
220
99
N05AH03
ATC
olanzapine; systemic
60.7
148.7
176
73
N05AH04
ATC
quetiapine; oral
25.4
119.4
197
229
N05AX08
ATC
risperidone; systemic
31.5
110.4
155
103
N04AA02
ATC
biperiden; systemic
87.2
93.9
102
18
N05AA02
ATC
levomepromazine; systemic
40.7
91.5
116
47
N03AG01
ATC
valproic acid; systemic, rectal
34.7
91.2
121
59
N05AX12
ATC
aripiprazole; systemic
41.8
75.2
94
33
N05AB03
ATC
perphenazine; systemic, rectal
35.5
69.9
91
37
N05AN01
ATC
lithium; oral
51.6
68.9
82
22
N05BA06
ATC
lorazepam; systemic, sublingual
21.3
63.9
98
68
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
60.6
63.3
73
16
N05AF03
ATC
chlorprothixene; systemic
47.9
62.1
75
21
F29
ICD-10 Finland
Unspecified nonorganic psychosis
37.3
55.6
71
25
F20.9
ICD-10 Finland
Schizophrenia, unspecified
43.8
52.9
65
19
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
52.6
49.9
59
14
N05BA04
ATC
oxazepam; oral
7.2
49.5
159
424
N05CD07
ATC
temazepam; oral
7.8
43.2
116
230
P72
ICPC
Schizophrenia
40.3
42.5
53
16
N05AD01
ATC
haloperidol; systemic
20.9
39.3
59
35
N05BA01
ATC
diazepam; systemic, rectal
6.9
37.4
108
230
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
46.9
36.5
44
11
N05AC02
ATC
thioridazine; oral
31.8
36.4
48
18
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
27.2
36.4
50
22
R25.1
ICD-10 Finland
Tremor, unspecified
18.6
35.2
55
36
N06AB04
ATC
citalopram; systemic
5.5
34.9
129
369
N05AH02
ATC
clozapine; systemic
31.2
34.0
45
17
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
39.6
32.9
41
12
N05AA01
ATC
chlorpromazine; systemic, rectal
28.6
32.6
44
18
C07AA05
ATC
propranolol; systemic
5.8
32.1
107
266
F31.20
ICD-10 Finland
Bipolar disorder, manic episode with mood-congruent psychotic symptoms
58.5
31.1
36
7
T36
ICD-10 Finland
Poisoning by systemic antibiotics
15.7
30.6
51
39
G20
ICD-10 Finland
Parkinson disease
17.1
30.6
49
34
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
45.4
29.8
36
9
P29
ICPC
Psychological sympt/compl other
13.3
29.6
53
48
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
32.4
28.4
37
13
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
35.8
25.2
32
10
N05BE01
ATC
buspirone; oral
17.9
25.0
39
25
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
21.5
24.6
36
19
A28
ICPC
Limited function/disability NOS
5.2
24.6
87
222
F31
ICD-10 Finland
Bipolar affective disorder
45.9
24.1
29
7
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
15.9
23.9
39
28
F22.0
ICD-10 Finland
Delusional disorder
37.0
23.9
30
9
F31.1
ICD-10 Finland
Bipolar affective disorder, current episode manic without psychotic symptoms
51.5
23.8
28
6
N05CF01
ATC
zopiclone; oral
3.7
23.4
148
646
N06AB06
ATC
sertraline; oral
6.1
23.2
68
138
N03AE01
ATC
clonazepam; systemic
8.2
22.8
53
77
P99
ICPC
Psychological disorders other
16.3
22.3
36
25
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
23.8
21.3
30
14
N03AX09
ATC
lamotrigine; oral
10.9
21.2
41
43
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
32.9
21.0
27
9
N06AX11
ATC
mirtazapine; oral
3.4
20.3
134
582
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
6.3
20.2
57
109
R53
ICD-10 Finland
Malaise and fatigue
3.9
20.2
98
334
N05AL01
ATC
sulpiride; systemic
31.6
20.0
26
9
SPAT1240
SPAT
Therapeutic discussion
6.0
19.7
58
117
N05AF01
ATC
flupentixol; systemic
16.6
18.9
30
20
N06AX16
ATC
venlafaxine; oral
4.3
18.9
78
227
SPAT1234
SPAT
Support of social functional capacity
7.9
18.8
44
64
N06AX03
ATC
mianserin; oral
8.4
18.8
42
57
A06AD11
ATC
lactulose; oral
4.2
18.7
80
241
F32.9
ICD-10 Finland
Depressive episode, unspecified
5.2
18.6
62
144
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
9.0
18.2
39
49
P98
ICPC
Psychosis NOS/other
56.4
18.2
21
*
N05AF05
ATC
zuclopenthixol; systemic
22.7
17.6
25
12
F25.00
ICD-10 Finland
Schizoaffective syndrome, manic type with only simultaneous bipolar and schizophrenic symptoms
27.6
17.2
23
9
F20.09
ICD-10 Finland
Paranoid schizophrenia UNS
37.6
16.9
21
6
N06AA12
ATC
doxepin; systemic
6.6
16.6
44
77
G21.9
ICD-10 Finland
Secondary parkinsonism, unspecified
42.8
16.6
20
5
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
26.3
16.3
22
9
188
Kela drug reimbursment
Psychosis requiring demanding treatment
22.6
16.3
23
11
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
22.6
16.3
23
11
F20.5
ICD-10 Finland
Residual schizophrenia
50.6
16.2
19
*
N06AG02
ATC
moclobemide; oral
7.7
16.1
38
56
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
6.0
16.0
46
89
IGY02
NOMESCO Finland
Psychiatric monitoring contact
17.0
16.0
25
16
F25.20
ICD-10 Finland
Schizoaffective syndrome, mixed type with only concomitant bipolar and schizophrenic symptoms
35.7
16.0
20
6
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
9.9
15.9
32
36
G25.1
ICD-10 Finland
Drug-induced tremor
+∞
15.8
15
*
F31.3
ICD-10 Finland
Bipolar affective disorder, current episode mild or moderate depression
40.5
15.6
19
5
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.7
15.3
77
262
N07BB01
ATC
disulfiram; oral
8.5
15.1
33
43
L28
ICPC
Limited function/disability (L)
3.5
15.1
81
290
F31.5
ICD-10 Finland
Bipolar affective disorder, current episode severe depression with psychotic symptoms
60.0
14.9
17
*
F25.10
ICD-10 Finland
Schizoaffective syndrome, depressive type with only concomitant bipolar and schizophrenic symptoms
26.7
14.9
20
8
SPAT1254
SPAT
Administration of medicine
3.8
14.7
70
227
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.9
14.7
50
118
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.6
14.6
75
259
29999
ICD-8 Finland
Unspecified psychosis
44.9
14.3
17
*
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
16.9
14.2
22
14
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
5.9
14.1
40
76
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
25.3
14.0
19
8
AA400
NOMESCO Finland
Electroconvulsive therapy
36.0
13.7
17
5
F31.2
ICD-10 Finland
Bipolar affective disorder, current episode manic with psychotic symptoms
146.6
13.6
14
*
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
8.6
13.5
29
37
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.9
13.4
97
424
F31.8
ICD-10 Finland
Other bipolar affective disorders
16.1
13.3
21
14
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
8.7
13.2
28
35
2968A
ICD-9 Finland
Affective psychoses, Manic-depressive psychosis, other and unspecified
23.9
13.1
18
8
N05AE04
ATC
ziprasidone; systemic
52.5
13.0
15
*
N05AX13
ATC
paliperidone; systemic
52.5
13.0
15
*
EBA30
NOMESCO Finland
Excision of root of tooth
6.2
12.9
35
63
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
16.4
12.8
20
13
SPAT1216
SPAT
Assessment of functional ability
3.3
12.8
74
277
G25.0
ICD-10 Finland
Essential tremor
11.8
12.8
23
21
F20.04
ICD-10 Finland
Paranoid schizophrenia with partial recurrence
33.7
12.7
16
5
29580
ICD-8 Finland
Schizophrenia, Other
33.7
12.7
16
5
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
18.4
12.7
19
11
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
5.3
12.7
39
82
G72.8
ICD-10 Finland
Other specified myopathies
21.2
12.6
18
9
U04
ICPC
Incontinence urine
6.4
12.5
33
57
AA1AD
NOMESCO Finland
CT of head and brain
2.9
12.5
95
424
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
15.2
12.5
20
14
N06AB03
ATC
fluoxetine; oral
3.5
12.4
63
214
F21
ICD-10 Finland
Schizotypal disorder
39.4
12.3
15
*
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
6.0
12.3
34
63
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
28.1
12.2
16
6
F10.20
ICD-10 Finland
Alcohol dependence currently independent
14.2
12.1
20
15
K08.3
ICD-10 Finland
Retained dental root
4.9
11.8
39
89
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
5.3
11.7
36
76
F25.01
ICD-10 Finland
Schizoaffective syndrome, manic type with prolonged schizophrenic than bipolar symptoms
124.8
11.5
12
*
N06AA04
ATC
clomipramine; systemic
15.9
11.5
18
12
SPAT1301
SPAT
No procedures
2.5
11.4
114
594
N06AX05
ATC
trazodone; oral
10.7
11.2
21
21
R41.0
ICD-10 Finland
Disorientation, unspecified
9.4
11.0
22
25
K59.0
ICD-10 Finland
Constipation
5.1
10.9
34
73
29570
ICD-8 Finland
Schizophrenia, Schizo-affective type
29.3
10.8
14
5
F22.9
ICD-10 Finland
Persistent delusional disorder, unspecified
29.3
10.8
14
5
F20
ICD-10 Finland
Schizophrenia
29.3
10.8
14
5
IGY99
NOMESCO Finland
Other psychiatric treatment contact
22.5
10.8
15
7
SPAT1243
SPAT
Psychiatric/psychological examination
11.9
10.7
19
17
IFA99
NOMESCO Finland
Other psychiatric pharmacotherapy service
62.4
10.7
12
*
N06AA06
ATC
trimipramine; systemic
7.6
10.5
24
34
F31.31
ICD-10 Finland
Bipolar disorder depressive episode with somatic syndrome
114.0
10.5
11
*
29830
ICD-8 Finland
Other psychoses, Acute paranoid reaction
+∞
10.5
10
*
F60.9
ICD-10 Finland
Personality disorder, unspecified
33.9
10.4
13
*
SPAT1241
SPAT
Extensive assessment of psychosocial situation
33.9
10.4
13
*
A04
ICPC
Weakness/tiredness general
3.2
10.3
57
204
N05AD03
ATC
melperone; systemic
13.8
10.3
17
13
N05CD02
ATC
nitrazepam; oral
11.9
10.2
18
16
EBA00
NOMESCO Finland
Extraction of tooth
2.4
10.2
112
605
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
4.9
10.2
33
74
30041
ICD-8 Finland
Neuroses, Depressiva
15.3
10.1
16
11
2957A
ICD-9 Finland
Schizophrenic psychoses, Schizo-affective type
41.6
10.0
12
*
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
3.3
10.0
54
188
SPAT1307
SPAT
Psychosocial counselling and guidance
6.2
9.9
26
45
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
4.1
9.9
39
106
N03AF01
ATC
carbamazepine; oral, rectal
4.5
9.9
35
86
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
8.3
9.8
21
27
F05.9
ICD-10 Finland
Delirium, unspecified
10.6
9.7
18
18
F03
ICD-10 Finland
Unspecified dementia
7.0
9.6
23
35
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
6.6
9.6
24
39
N05AC01
ATC
periciazine; systemic
22.6
9.4
13
6
P76
ICPC
Depressive disorder
5.0
9.2
29
63
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
12.0
9.2
16
14
N29
ICPC
Neurological sympt/complt other
9.5
9.2
18
20
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
4.1
9.1
35
93
29599
ICD-8 Finland
Schizophrenia, Unspecified type
24.9
9.0
12
5
N06AX22
ATC
agomelatine; oral
13.1
9.0
15
12
P01
ICPC
Feeling anxious/nervous/tense
4.1
8.9
34
90
N06AB05
ATC
paroxetine; oral
4.6
8.8
30
71
2989X
ICD-9 Finland
Other nonorganic psychoses, Unspecified psychosis
14.6
8.8
14
10
29540
ICD-8 Finland
Acute schizophrenia episode
51.6
8.7
10
*
N06AA09
ATC
amitriptyline; systemic
3.2
8.7
46
160
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.9
8.6
55
215
C03CA01
ATC
furosemide; systemic
2.2
8.6
103
572
N30.0
ICD-10 Finland
Acute cystitis
2.9
8.6
56
224
3018X
ICD-9 Finland
Personality disorders, Other personality disorders[MUU TAI SEKAMUOTOINEN PERSOONALLISUUSHÄIRIÖ]
20.8
8.5
12
6
D12
ICPC
Constipation
6.2
8.5
22
38
F25
ICD-10 Finland
Schizoaffective disorders
92.6
8.5
9
*
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
4.7
8.4
28
65
F61.0
ICD-10 Finland
Mixed personality disorders
11.2
8.4
15
14
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.5
8.4
39
123
IEY02
NOMESCO Finland
Intensified psychiatric outpatient care, Assertive Community Treatment (ACT)
+∞
8.4
8
*
IEV99
NOMESCO Finland
Other psychiatric network intervention
+∞
8.4
8
*
N39.4
ICD-10 Finland
Other specified urinary incontinence
3.5
8.3
39
124
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.2
8.3
104
588
E950A
ICD-9 Finland
Suicide and self-inflicted poisoning by solid or liquid substances
17.8
8.1
12
7
G21.0
ICD-10 Finland
Malignant neuroleptic syndrome
34.4
8.1
10
*
F25.21
ICD-10 Finland
Schizoaffective syndrome, mixed type with prolonged schizophrenic than bipolar symptoms
34.4
8.1
10
*
N05BA12
ATC
alprazolam; oral
3.1
8.0
45
162
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.3
8.0
89
474
N28
ICPC
Limited function/disability (N)
8.1
8.0
17
22
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.6
7.9
35
106
SPAT1252
SPAT
Overall medication plan or its review
3.8
7.8
33
96
N06AB10
ATC
escitalopram; oral
2.5
7.8
65
297
P28
ICPC
Limited function/disability (P)
15.6
7.8
12
8
L17
ICPC
Foot/toe symptom/complaint
2.2
7.8
91
496
F23.90
ICD-10 Finland
Acute and transient psychosis, unspecified without acute stress factor
46.2
7.8
9
*
H03AA01
ATC
levothyroxine sodium; systemic
2.3
7.7
81
416
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.8
7.7
51
205
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.8
7.7
32
92
F34.1
ICD-10 Finland
Dysthymia
6.1
7.7
20
35
F20.0
ICD-10 Finland
Paranoid schizophrenia
12.3
7.7
13
11
29530
ICD-8 Finland
Schizophrenia, Paranoid type
25.8
7.6
10
*
97010
ICD-8 Finland
Adverse effect of psychotherapeutics, Tranquillisers
25.8
7.6
10
*
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
25.8
7.6
10
*
N30.9
ICD-10 Finland
Cystitis, unspecified
4.4
7.5
26
63
SPAT1235
SPAT
Mental health, emotional support
82.1
7.5
8
*
IGY02
SPAT
NA
82.1
7.5
8
*
IHZ07
SPAT
NA
82.1
7.5
8
*
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
13.8
7.4
12
9
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
4.2
7.4
27
69
N99
ICPC
Neurological disease other
11.3
7.4
13
12
N05AB01
ATC
dixyrazine; systemic
11.3
7.4
13
12
N05AE05
ATC
lurasidone; oral
+∞
7.3
7
*
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.6
7.3
55
239
30188
ICD-8 Finland
Personality disorders, Alia definita
16.3
7.3
11
7
F41.3
ICD-10 Finland
Other mixed anxiety disorders
16.3
7.3
11
7
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.6
7.2
54
232
A10BA02
ATC
metformin; oral
2.1
7.2
100
581
F25.1
ICD-10 Finland
Schizoaffective disorder, depressive type
30.8
7.2
9
*
P73
ICPC
Affective psychosis
30.8
7.2
9
*
F33.4
ICD-10 Finland
Recurrent depressive disorder, currently in remission
10.4
7.1
13
13
N06AB08
ATC
fluvoxamine; oral
5.7
7.0
19
35
G04BD08
ATC
solifenacin; oral
3.5
7.0
32
100
R60.0
ICD-10 Finland
Localized oedema
2.8
7.0
45
179
113
Kela drug reimbursment
Anxiety disorders associated with mental retardation
41.0
6.8
8
*
AA5EN
NOMESCO Finland
Brain reseptor or transprot protein distribution isotope imaging
41.0
6.8
8
*
2953E
ICD-9 Finland
Schizophrenic psychoses, Paranoid type[PARANOIDISTYYPPINEN SKITSOFRENIA,KROONINEN AKUUTTI]
41.0
6.8
8
*
F25.0
ICD-10 Finland
Schizoaffective disorder, manic type
41.0
6.8
8
*
F23.91
ICD-10 Finland
Acute and transient psychosis, unspecified without acute stress factor
41.0
6.8
8
*
SPAT1229
SPAT
Assessment of need for aid
3.0
6.8
39
144
K02.1
ICD-10 Finland
Caries of dentine
1.9
6.7
159
1128
SPAT1305
SPAT
Counselling and guidance related to physical exercise
3.1
6.7
37
131
N06AX12
ATC
bupropion; oral
4.2
6.7
24
61
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.0
6.6
98
585
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.9
6.6
41
158
SPAT1215
SPAT
Assessment of need for medical rehabilitation
4.0
6.6
25
67
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.3
6.6
23
57
SPAT1172
SPAT
Guidance concerning hydration
6.4
6.6
16
26
G23.9
ICD-10 Finland
Degenerative disease of basal ganglia, unspecified
71.4
6.5
7
*
G21.8
ICD-10 Finland
Other secondary parkinsonism
71.4
6.5
7
*
F33.31
ICD-10 Finland
Recurrent depression, severe episode of somatic syndrome
71.4
6.5
7
*
F23.99
ICD-10 Finland
Acute and transient psychosis, unspecified UNS
71.4
6.5
7
*
SPAT1167
SPAT
Insertion of urinary catheter
4.8
6.4
20
44
R50.9
ICD-10 Finland
Fever, unspecified
2.5
6.3
52
236
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.3
6.3
63
315
3018D
ICD-9 Finland
Personality disorders, Other personality disorders[EPÄVAKAA PERSOONALLISUUS]
18.5
6.3
9
5
P03
ICPC
Feeling depressed
3.5
6.3
28
86
N87
ICPC
Parkinsonism
7.3
6.3
14
20
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
4.4
6.3
21
50
G25.2
ICD-10 Finland
Other specified forms of tremor
27.3
6.3
8
*
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
27.3
6.3
8
*
F25.2
ICD-10 Finland
Schizoaffective disorder, mixed type
27.3
6.3
8
*
2959C
ICD-9 Finland
Schizophrenic psychoses, Unspecified schizophrenia[ERILAISTUMATON SKITSOFRENIA,KROONINEN]
27.3
6.3
8
*
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
6.0
6.2
16
28
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
12.9
6.1
10
8
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
12.9
6.1
10
8
103
Kela drug reimbursment
Diabetes, insulin-treated
2.0
6.1
93
556
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
6.3
6.1
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
36
13
31.21
53.73
11.4
15.8
1064.6
1580.2
nmol/l
1.36
36
13
139
493
4.31
34.74
2.5
1.7
1176.8
1244.1
nmol/l
0.35
106
375
164
858
2.94
19.39
3.0
3.5
2.4
2.3
mmol/l
0.51
133
739
203
1209
2.98
18.55
6.2
6.2
1.2
1.2
mmol/l
0.96
190
1095
212
1300
3.01
18.21
7.4
7.2
1.2
1.2
mmol/l
1.72
184
1108
102
428
3.06
17.74
2.4
1.9
—
—
—
0
0
185
1068
2.82
17.59
2.9
2.0
96.3
95.4
pmol/l
0.09
111
525
148
800
2.63
15.47
3.4
2.1
727.2
278.4
u/l
0.51
138
743
188
1144
2.64
15.32
4.5
4.7
33.9
35.5
g/l
2.91
176
1078
124
617
2.69
15.30
1.8
1.6
18.4
21.1
nmol/l
1.40
105
512
14
11
13.28
14.35
2.6
2.0
—
—
—
0
0
214
1461
2.51
12.56
16.2
9.5
4.3
4.1
e9/l
0.43
189
1287
115
598
2.47
12.48
2.5
2.1
3.2
3.4
mg/l
0.35
94
514
71
292
2.86
12.36
1.9
1.7
1.6
1.5
%
0.19
63
247
49
165
3.34
12.01
1.7
1.5
—
—
—
0
0
145
848
2.34
11.95
2.7
2.5
48.6
56.2
u/l
2.58
130
778
252
1889
2.81
11.67
5.9
3.8
14.7
14.9
pmol/l
0.39
226
1681
104
536
2.42
11.33
1.9
1.8
473.9
452.0
pmol/l
0.34
83
435
35
99
3.86
11.11
2.7
1.9
—
—
—
0
0
33
91
3.94
10.85
2.5
1.7
—
—
—
0
0
45
157
3.18
10.37
2.0
1.5
—
—
—
0
0
215
1555
2.26
9.81
7.3
5.1
6.9
6.8
mmol/l
0.15
207
1459
163
1064
2.13
9.61
2.6
2.2
75.6
78.0
nmol/l
0.45
145
937
140
869
2.12
9.36
3.6
3.3
31.0
32.5
u/l
0.16
130
827
255
2021
2.50
8.80
8.1
7.8
80.6
80.2
u/l
0.06
248
1884
42
156
2.96
8.67
4.9
3.6
2.0
2.1
mmol/l
0.04
37
124
65
304
2.44
8.54
2.1
1.9
—
—
—
0
0
68
325
2.40
8.51
4.7
9.4
2.8
1.2
mmol/l
1.23
53
267
64
300
2.43
8.35
2.1
1.8
—
—
—
0
0
68
335
2.32
7.91
3.6
5.5
1.0
1.0
mmol/l
0.10
59
311
48
201
2.64
7.90
3.1
3.8
94.0
80.8
ng/l
0.29
37
179
194
1416
1.99
7.75
4.9
6.5
8.9
11.5
umol/l
5.08
184
1335
144
953
1.96
7.63
4.3
3.2
—
—
—
0
0
80
435
2.13
7.27
1.8
3.4
0.8
0.8
mmol/l
0.36
69
408
50
232
2.38
6.61
3.3
2.5
5.0
6.9
ug/l
0.59
39
214
62
316
2.20
6.58
11.8
7.6
—
—
—
0
0
44
196
2.45
6.35
1.5
1.6
—
—
—
0
0
105
670
1.86
5.89
6.7
4.1
0.0
0.0
estimate
0.50
28
210
68
377
2.03
5.76
2.0
2.3
2.3
2.3
g/l
0.17
53
345
167
1235
1.77
5.65
5.9
3.8
0.0
0.0
estimate
0.00
28
214
49
244
2.20
5.47
4.4
3.7
3.6
2.0
mmol/l
1.81
38
196
211
1684
1.80
5.36
5.4
3.2
44.8
56.9
u/l
1.39
194
1560
268
2321
2.17
5.17
8.2
4.6
1.8
1.9
mu/l
0.80
251
2085
30
128
2.49
4.75
1.7
3.1
3.8
4.5
pmol/l
2.95
22
107
145
1066
1.68
4.74
6.7
3.8
310.8
39.0
ng/l
0.46
125
777
78
483
1.82
4.69
3.2
3.1
2.5
2.5
mmol/l
0.68
69
421
47
246
2.07
4.62
3.5
3.6
6.2
5.8
kpa
1.37
47
240
41
205
2.15
4.53
2.0
2.8
66.4
66.7
g/l
0.12
28
187
120
848
1.68
4.51
3.5
3.2
1294.6
1128.5
ng/l
0.26
101
713
85
547
1.76
4.47
7.0
4.2
1.0
1.0
kg/l
0.59
17
73
162
1241
1.64
4.41
7.4
5.1
0.0
0.0
estimate
0.00
29
211
164
1262
1.64
4.37
6.0
3.8
0.0
0.0
estimate
0.00
28
206
68
414
1.82
4.29
2.2
2.3
10.0
13.0
umol/l
3.87
58
378
226
1902
1.70
4.11
4.3
4.1
14.0
12.5
mm/h
0.65
210
1737
11
28
4.04
4.01
2.6
2.1
—
—
—
0
0
25
108
2.43
3.87
5.3
10.0
1.8
1.7
%
0.39
25
101
43
234
1.97
3.80
1.6
1.9
404.9
366.3
nmol/l
0.46
38
216
59
365
1.76
3.50
2.2
2.3
18.5
21.9
%
1.38
42
310
22
94
2.44
3.50
5.1
3.9
3.8
4.0
mmol/l
1.00
22
85
19
76
2.60
3.45
1.1
1.3
—
—
—
0
0
37
206
1.90
3.07
3.6
2.7
4.7
4.3
kpa
0.53
37
200
42
244
1.83
3.06
2.0
2.4
30.6
33.3
u/l
0.28
35
203
20
88
2.36
3.00
2.0
3.7
—
3.1
—
0
8
20
89
2.33
2.93
2.0
3.8
43.1
31.2
mg/l
0.37
15
71
20
89
2.33
2.93
2.0
3.8
48.7
132.5
mg/l
0.58
15
69
276
2530
1.85
2.87
26.9
15.0
29.8
23.5
mg/l
2.22
249
2012
73
509
1.57
2.72
4.6
3.8
86.9
238.2
ng/l
0.94
61
422
167
1382
1.45
2.68
3.0
2.6
—
—
—
0
0
122
956
1.46
2.59
7.2
4.0
—
—
—
0
0
23
115
2.08
2.58
2.1
2.1
0.8
4.5
ug/l
0.87
16
108
20
96
2.16
2.49
1.9
2.2
9.8
10.3
g/l
0.16
11
85
124
983
1.44
2.44
3.2
2.6
145.1
146.2
ug/l
0.02
112
895
97
736
1.46
2.40
4.2
3.1
0.3
0.5
e6/l
0.87
75
549
53
355
1.60
2.33
21.5
20.5
1.3
1.3
inr
—
6
45
26
145
1.87
2.18
3.2
10.3
26.1
24.5
mmol/l
0.57
21
136
12
50
2.46
2.05
1.8
1.4
—
—
—
0
0
12
50
2.46
2.05
1.8
1.4
—
—
—
0
0
20
106
1.95
1.96
1.9
2.1
7.1
7.6
g/l
—
10
81
20
106
1.95
1.96
1.9
2.1
3.7
3.7
g/l
—
10
77
20
106
1.95
1.96
1.9
2.1
—
—
—
0
0
75
562
1.44
1.95
2.0
1.7
0.9
1.3
mg/l
1.59
60
448
19
99
1.98
1.95
1.9
2.2
2.7
3.2
g/l
—
10
79
283
2669
1.72
1.90
32.7
17.7
139.9
139.7
mmol/l
0.52
277
2596
33
207
1.67
1.89
3.7
2.9
170.9
169.1
ng/l
0.01
28
185
64
470
1.46
1.85
3.3
2.7
0.7
1.1
e6/l
0.86
39
270
44
302
1.53
1.76
1.8
3.0
6.9
8.6
umol/l
0.38
39
266
283
2678
1.67
1.75
32.4
17.8
4.1
4.0
mmol/l
4.50
277
2603
17
90
1.94
1.68
2.4
2.5
0.2
0.6
g/l
—
9
81
269
2521
1.52
1.68
7.1
4.8
6.2
6.1
mmol/l
1.11
249
2294
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
14
3.61
1.62
1.0
1.1
—
—
—
0
0
5
14
3.61
1.62
1.0
1.1
—
—
—
0
0
59
441
1.42
1.55
3.3
2.9
1.3
2.3
e6/l
1.09
33
245
49
355
1.45
1.52
5.8
4.5
30.5
30.9
%
0.08
33
231
21
124
1.74
1.51
1.5
2.0
—
—
—
0
0
16
87
1.88
1.49
1.3
2.3
38.2
37.6
g/l
—
8
75
77
608
1.35
1.46
2.1
2.3
—
—
—
0
0
5
16
3.16
1.44
1.4
1.1
2.5
1.9
mmol/l
—
5
16
262
2462
1.42
1.42
8.7
6.1
40.8
40.5
mmol/mol
0.22
240
2282
6
23
2.64
1.37
1.0
1.1
—
—
—
0
0
14
75
1.91
1.36
1.2
1.5
—
—
—
0
0
5
17
2.97
1.36
1.2
1.7
—
—
—
0
0
9
42
2.18
1.35
1.1
1.8
—
—
—
0
0
9
42
2.18
1.35
1.3
1.7
—
—
—
0
0
14
76
1.88
1.32
1.2
1.7
—
—
—
0
0
22
139
1.63
1.27
1.6
2.1
—
—
—
0
0
11
56
2.00
1.23
1.1
1.7
—
—
—
0
0
10
49
2.08
1.23
1.1
1.7
—
—
—
0
0
40
292
1.42
1.21
2.3
4.5
224.6
248.2
u/l
1.25
35
276
7
31
2.29
1.11
2.3
1.5
—
—
—
0
0
8
41
1.98
1.09
1.1
1.7
—
—
—
0
0
5
21
2.40
1.09
1.4
1.6
—
—
—
0
0
9
48
1.90
1.01
1.9
1.4
—
—
—
0
0
0
30
0.00
0.98
0.0
1.2
—
—
—
0
0
0
30
0.00
0.98
0.0
1.2
—
—
—
0
0
0
30
0.00
0.98
0.0
1.0
—
2.4
—
0
13
0
31
0.00
0.97
0.0
1.2
—
—
—
0
0
0
31
0.00
0.97
0.0
1.2
—
—
—
0
0
0
31
0.00
0.97
0.0
1.2
—
—
—
0
0
8
42
1.93
0.89
1.1
1.7
—
—
—
0
0
8
42
1.93
0.89
1.1
1.7
—
—
—
0
0
8
42
1.93
0.89
1.1
1.7
—
—
—
0
0
8
43
1.88
0.88
1.1
1.7
—
—
—
0
0
6
30
2.02
0.87
1.0
1.4
—
—
—
0
0
8
44
1.84
0.86
1.1
1.7
—
—
—
0
0
37
286
1.33
0.83
6.9
3.4
—
—
—
0
0
0
24
0.00
0.79
0.0
1.1
—
—
—
0
0
0
25
0.00
0.79
0.0
1.4
—
—
—
0
0
0
25
0.00
0.79
0.0
1.2
—
50.2
—
0
13
13
82
1.61
0.79
1.5
2.7
6.6
83.4
ug/min
—
7
46
32
411
0.75
0.77
1.3
1.3
35.0
10.8
u/ml
—
9
158
132
1193
1.19
0.75
3.9
4.1
—
—
—
0
0
12
76
1.60
0.72
1.3
1.4
—
—
—
0
0
10
61
1.66
0.69
1.1
1.1
—
14.8
—
0
7
62
526
1.22
0.69
1.3
1.2
1.7
1.5
u/ml
—
7
135
5
27
1.87
0.68
1.8
2.6
438.4
486.7
ml
—
5
14
5
28
1.80
0.66
1.2
2.1
—
—
—
0
0
5
28
1.80
0.66
1.2
2.1
—
—
—
0
0
5
28
1.80
0.66
1.2
2.1
—
—
—
0
0
7
44
1.60
0.65
1.3
1.5
—
—
—
0
0
5
29
1.74
0.64
1.2
1.2
—
1.4
—
0
9
35
431
0.79
0.63
1.3
1.3
11.2
36.6
iu/ml
—
8
139
18
131
1.40
0.60
1.1
1.1
22.7
134.9
iu/ml
—
7
55
0
20
0.00
0.60
0.0
1.0
—
—
—
0
0
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
29
358
0.79
0.54
1.3
1.4
—
—
—
0
0
49
570
0.83
0.53
2.8
2.9
0.7
0.8
ug/l
0.37
41
375
11
75
1.48
0.51
1.2
1.7
—
—
—
0
0
278
2722
1.21
0.42
15.3
10.9
25.8
26.8
u/l
0.24
272
2609
5
33
1.52
0.41
1.4
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
253
2461
1.15
0.41
4.8
4.3
1.6
1.3
mmol/l
3.59
224
2225
0
17
0.00
0.41
0.0
1.6
—
946.5
—
0
17
8
60
1.34
0.40
1.6
1.1
—
—
—
0
0
5
34
1.48
0.40
1.0
2.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.6
—
4.3
—
0
7
0
18
0.00
0.40
0.0
1.1
—
1.2
—
0
12
0
18
0.00
0.40
0.0
1.8
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
1.1
—
0
8
64
707
0.88
0.37
3.4
2.7
9311.0
8318.9
umol/l
0.04
51
599
15
117
1.30
0.36
1.1
1.0
—
—
—
0
0
6
45
1.34
0.34
1.5
2.1
—
—
—
0
0
7
52
1.35
0.31
1.3
1.9
—
—
—
0
0
261
2557
1.13
0.31
5.3
4.8
4.2
4.6
mmol/l
11.35
234
2342
103
971
1.09
0.27
4.0
4.6
1.9
2.4
ug/l
0.50
86
866
8
66
1.22
0.27
1.1
1.7
—
—
—
0
0
5
72
0.69
0.26
1.0
1.3
—
—
—
0
0
9
76
1.19
0.25
1.3
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
9.9
—
0
10
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
13.4
—
0
12
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
19
217
0.87
0.19
1.5
2.8
47.3
62.8
ml/min/173m2
—
6
93
231
2272
1.07
0.16
31.5
15.9
38.1
40.0
%
1.27
114
1588
9
78
1.16
0.15
1.2
1.2
—
—
—
0
0
9
78
1.16
0.15
1.2
1.2
—
—
—
0
0
7
88
0.79
0.14
2.9
1.5
—
—
—
0
0
13
113
1.16
0.13
1.2
1.3
—
—
—
0
0
6
58
1.04
0.08
1.5
1.4
—
—
—
0
0
5
64
0.78
0.08
1.2
1.3
—
—
—
0
0
6
71
0.84
0.07
1.5
2.1
107.7
83.4
%
—
6
65
8
74
1.08
0.07
1.1
1.4
—
—
—
0
0
244
2458
0.97
0.06
22.8
13.9
78.1
78.5
ml/min/173m2
0.10
204
2031
31
296
1.05
0.06
2.5
4.5
2.9
30.6
ug/l
1.05
25
252
74
725
1.03
0.04
1.6
1.7
1.6
1.4
mmol/l
0.79
66
597
28
271
1.04
0.02
1.9
1.4
—
—
—
0
0
255
2540
1.02
0.02
5.4
4.7
1.3
1.5
mmol/l
6.52
225
2307
77
780
0.98
0.02
3.4
4.1
22.3
21.3
%
0.19
35
367
262
2613
1.02
0.01
6.1
5.4
2.4
2.7
mmol/l
10.60
234
2379
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
87.8
—
0
5
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
9
98
0.92
0.00
4.1
3.2
—
—
—
0
0
6
67
0.89
0.00
1.5
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
1.3
—
0
6
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
23.8
—
0
6
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint OTHER_DRUGADVERS_SECONDA_PARKINSONI and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| OTHER_DRUGADVERS_SECONDA_PARKINSONI | 2.378 [2.09, 2.71] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.129 |
During the follow-up period (1.1.1998 — 31.12.2019), 653 out of 1405 females with OTHER_DRUGADVERS_SECONDA_PARKINSONI died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| OTHER_DRUGADVERS_SECONDA_PARKINSONI | 2.878 [2.39, 3.47] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.022 |
During the follow-up period (1.1.1998 — 31.12.2019), 476 out of 955 males with OTHER_DRUGADVERS_SECONDA_PARKINSONI died.
Mortality risk
Mortality risk for people of age
years, who have OTHER_DRUGADVERS_SECONDA_PARKINSONI.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.252% | 0.529% |
| 5 | 1.105% | 3.197% |
| 10 | 3.376% | 7.776% |
| 15 | 6.141% | 14.768% |
| 20 | 10.724% | 23.847% |
Relationships between endpoints
↥Index endpoint: OTHER_DRUGADVERS_SECONDA_PARKINSONI – Other drug-induced secondary parkinsonism
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data