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Epidural haemorrhage

ST19_EPIDU_HAEMORRHAGE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 S06.4
  • Hospital discharge: ICD-9 852[4-5]
  • Cause of death: ICD-10 S06.4
  • Cause of death: ICD-9 852[4-5]

2 out of 7 registries used, show all original rules.

369

4. Check minimum number of events

None

369

5. Include endpoints

None

369

6. Filter based on genotype QC (FinnGen only)

369

Control definitions (FinnGen only)

Control exclude
NEURODIS

Extra metadata

Level in the ICD hierarchy
4
Special
ST19_EDHTRAU
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
S06
Name in latin
Haemorrhagia epiduralis traumatica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 369 108 261
Unadjusted period prevalence (%) 0.09 0.04 0.12
Median age at first event (years) 48.10 48.51 47.93

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
339
Matched controls
3389
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
S06.4
ICD-10 Finland
Epidural haemorrhage
+∞
323.0
282
*
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
+∞
148.0
131
*
AA1AD
NOMESCO Finland
CT of head and brain
20.7
101.9
165
148
S06.3
ICD-10 Finland
Focal brain injury
1125.2
91.2
85
*
T90.5
ICD-10 Finland
Sequelae of intracranial injury
1055.5
86.6
81
*
AAD00
NOMESCO Finland
Evacuation of epidural haematoma
+∞
81.6
75
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
8.6
67.6
190
439
S06.0
ICD-10 Finland
Concussion
52.6
57.4
68
16
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
+∞
55.8
52
*
S06.2
ICD-10 Finland
Diffuse brain injury
+∞
54.7
51
*
S06.6
ICD-10 Finland
Traumatic subarachnoid haemorrhage
+∞
42.6
40
*
W19
ICD-10 Finland
Unspecified fall
11.7
42.0
82
90
R56.8
ICD-10 Finland
Other and unspecified convulsions
21.6
39.1
58
32
2211
FHL
Hematoma removal, epidural
+∞
36.1
34
*
X59
ICD-10 Finland
Exposure to unspecified factor
5.9
35.7
116
275
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.3
32.8
98
206
S02.11
ICD-10 Finland
Fracture of base of skull, open
355.3
32.4
32
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
9.3
32.4
71
94
G40.9
ICD-10 Finland
Epilepsy, unspecified
+∞
31.8
30
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
7.5
31.5
80
134
S02.00
ICD-10 Finland
Fracture of the upper part of the head closed
342.6
31.4
31
*
NA1AD
NOMESCO Finland
Cervical spine CT examination
20.3
30.6
46
26
XA800
NOMESCO Finland
Neuropsychological investigation
31.2
29.6
39
14
AAD10
NOMESCO Finland
Evacuation of chronic subdural haematoma
+∞
29.6
28
*
S02.10
ICD-10 Finland
Fracture of base of skull, closed
113.3
29.2
31
*
ZXD05
NOMESCO Finland
Urgent procedure
3.9
28.5
157
611
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
305.1
28.2
28
*
N03AX14
ATC
levetiracetam; systemic
109.3
28.1
30
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
+∞
27.5
26
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
13.5
24.0
42
35
G47.3
ICD-10 Finland
Sleep apnoea
14.5
23.1
39
30
N03AF01
ATC
carbamazepine; oral, rectal
16.4
23.1
37
25
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.7
22.3
85
227
N03AF02
ATC
oxcarbazepine; oral
122.9
21.8
23
*
N03AG01
ATC
valproic acid; systemic, rectal
12.1
21.3
39
36
W10
ICD-10 Finland
Fall on and from stairs and steps
10.9
21.3
41
42
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
222.9
20.8
21
*
K90
ICPC
Stroke/cerebrovascular accident
+∞
20.0
19
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
+∞
20.0
19
*
N03AB02
ATC
phenytoin; systemic
+∞
18.9
18
*
AAA27
NOMESCO Finland
Insertion of intracerebral pressure monitoring device
+∞
18.9
18
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
200.5
18.7
19
*
S01.0
ICD-10 Finland
Open wound of scalp
6.0
16.8
48
91
AAD05
NOMESCO Finland
Evacuation of acute subdural haematoma
+∞
16.8
16
*
X58
ICD-10 Finland
Exposure to other specified factors
4.0
16.3
72
216
8524B
ICD-9 Finland
Subarachnoid, subdural and extradural haemorrhage, following injury, Extradural haemorrhage following injury without mention of open intracranial wound[HAEMORRHAGIA EPIDURALIS TRAUMATICA,EI TAJUTTOMUUTTA]
+∞
15.7
15
*
8524A
ICD-9 Finland
Subarachnoid, subdural and extradural haemorrhage, following injury, Extradural haemorrhage following injury without mention of open intracranial wound[HAEMORRHAGIA EPIDURALIS TR ,EI TIETOA TAJUTTOMUUDES]
+∞
15.7
15
*
F10.25
ICD-10 Finland
Alcohol dependence continuous use
23.4
15.7
22
10
F10.24
ICD-10 Finland
Alcohol depence active use
21.1
13.9
20
10
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
10.0
13.7
27
29
W17
ICD-10 Finland
Other fall from one level to another
7.6
13.7
32
46
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
+∞
13.6
13
*
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
+∞
13.6
13
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.6
13.6
127
635
F10.20
ICD-10 Finland
Alcohol dependence currently independent
12.2
13.5
24
21
F10.09
ICD-10 Finland
Alcohol intoxication UNS
15.9
13.3
21
14
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
41.8
13.3
16
*
ZXD35
NOMESCO Finland
Usual procedure
9.4
13.3
27
31
E882A
ICD-9 Finland
Fall from or out of building or other structure
17.6
13.1
20
12
G40
ICD-10 Finland
Epilepsy
+∞
12.6
12
*
JN5BD
NOMESCO Finland
Head and body CT examination for trauma
48.4
12.0
14
*
P15
ICPC
Chronic alcohol abuse
9.5
12.0
24
27
Z2445
NOMESCO Finland
Psychologist
10.2
11.9
23
24
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
6.3
11.8
31
53
F05.9
ICD-10 Finland
Delirium, unspecified
23.9
11.7
16
7
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
6.8
11.7
29
46
T36
ICD-10 Finland
Poisoning by systemic antibiotics
7.9
11.7
26
35
S06.9
ICD-10 Finland
Intracranial injury, unspecified
+∞
11.5
11
*
AAF00
NOMESCO Finland
Ventriculostomy
123.9
11.5
12
*
N05AH04
ATC
quetiapine; oral
3.5
11.4
56
182
R4120
NOMESCO Finland
Occupational therapy
6.5
11.3
29
48
A28
ICPC
Limited function/disability NOS
3.9
11.2
47
134
N02BE01
ATC
paracetamol; systemic, rectal
2.4
11.1
269
2069
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
6.0
10.7
29
52
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
11.8
10.7
19
17
S22.4
ICD-10 Finland
Multiple fractures of ribs
10.5
10.7
20
20
N05CF01
ATC
zopiclone; oral
2.4
10.6
102
507
S02.01
ICD-10 Finland
Fracture of the upper part of the head open
+∞
10.5
10
*
N06AX11
ATC
mirtazapine; oral
2.5
10.5
95
456
R51.80
ICD-10 Finland
Headache
3.9
10.2
43
123
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.3
10.0
53
182
N05BA01
ATC
diazepam; systemic, rectal
3.3
10.0
51
171
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
17.3
10.0
15
9
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.5
9.9
86
402
V19
ICD-10 Finland
Pedal cyclist injured in other and unspecified transport accidents
10.0
9.9
19
20
S42.0
ICD-10 Finland
Fracture of clavicle
7.8
9.9
22
30
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
13.9
9.8
16
12
WX730
NOMESCO Finland
Conventional respirator
11.9
9.7
17
15
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
22.4
9.4
13
6
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
+∞
9.4
9
*
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
+∞
9.4
9
*
G44.2
ICD-10 Finland
Tension-type headache
4.5
9.4
33
80
Z2446
NOMESCO Finland
Social worker
4.9
9.2
29
63
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
10.5
9.1
17
17
N29
ICPC
Neurological sympt/complt other
24.8
9.0
12
5
N05AH03
ATC
olanzapine; systemic
4.5
8.6
30
72
V49.9
ICD-10 Finland
Car occupant [any] injured in unspecified traffic accident
6.7
8.6
21
33
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
16.8
8.6
13
8
Z3226
NOMESCO Finland
Physiotherapist
2.8
8.6
59
238
SPAT1215
SPAT
Assessment of need for medical rehabilitation
7.7
8.6
19
26
N02AX02
ATC
tramadol; systemic, rectal
2.1
8.5
128
767
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.4
8.5
41
132
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
92.2
8.4
9
*
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
92.2
8.4
9
*
AAK00
NOMESCO Finland
Cranioplasty
+∞
8.4
8
*
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
+∞
8.4
8
*
G41.9
ICD-10 Finland
Status epilepticus, unspecified
+∞
8.4
8
*
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
14.9
8.3
13
9
N07BB01
ATC
disulfiram; oral
4.5
8.2
28
66
W00
ICD-10 Finland
Fall on same level involving ice and snow
3.4
8.2
39
124
R41.0
ICD-10 Finland
Disorientation, unspecified
12.1
8.1
14
12
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
9.3
8.1
16
18
S02.40
ICD-10 Finland
Fracture of malar and maxillary bones, closed
9.3
8.1
16
18
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
22.6
8.1
11
5
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
13.4
7.9
13
10
AA3AD
NOMESCO Finland
CT of face
46.0
7.7
9
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.8
7.7
32
91
N06AB10
ATC
escitalopram; oral
2.6
7.7
60
262
ZXD00
NOMESCO Finland
Emergency procedure
5.7
7.7
21
39
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
6.0
7.6
20
35
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
4.1
7.6
28
72
N03AX12
ATC
gabapentin; oral
3.1
7.6
40
138
N06AB04
ATC
citalopram; systemic
2.5
7.5
60
266
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
5.5
7.5
21
40
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.5
7.5
21
40
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
81.7
7.4
8
*
Y96.9
ICD-10 Finland
Unspecified type of accident
13.8
7.4
12
9
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
13.8
7.4
12
9
R53
ICD-10 Finland
Malaise and fatigue
2.6
7.4
56
241
183
Kela drug reimbursment
Lamotrigin and topiramate
+∞
7.3
7
*
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
+∞
7.3
7
*
85000
ICD-8 Finland
Concussion, Current or unspecified
+∞
7.3
7
*
G72.8
ICD-10 Finland
Other specified myopathies
+∞
7.3
7
*
N03AX18
ATC
lacosamide; systemic
+∞
7.3
7
*
S22.3
ICD-10 Finland
Fracture of rib
3.8
7.3
30
85
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
16.2
7.3
11
7
JN4BD
NOMESCO Finland
Extensive body CT
2.9
7.2
43
161
V14.9
ICD-10 Finland
Pedal cyclist injured in collision with heavy transport vehicle or bus, unspecified pedal cyclist injured in traffic accident
30.7
7.2
9
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
5.9
7.2
19
34
Z3231
NOMESCO Finland
Registered nurse
2.1
7.1
86
465
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
7.2
7.1
16
23
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
7.0
121
753
EBA00
NOMESCO Finland
Extraction of tooth
2.0
6.9
108
644
F29
ICD-10 Finland
Unspecified nonorganic psychosis
4.7
6.9
22
49
N80
ICPC
Head injury other
11.2
6.8
12
11
R5140
NOMESCO Finland
Monitoring the use of the aid
4.9
6.8
21
45
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
40.9
6.8
8
*
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
40.9
6.8
8
*
N18
ICPC
Paralysis/weakness
40.9
6.8
8
*
N03AX11
ATC
topiramate; oral
17.1
6.8
10
6
N06AX16
ATC
venlafaxine; oral
2.9
6.7
39
144
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
9.0
6.6
13
15
GBB00
NOMESCO Finland
Tracheostomy
10.3
6.6
12
12
N05CD07
ATC
temazepam; oral
2.8
6.6
41
156
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
6.6
96
559
S42.2
ICD-10 Finland
Fracture of upper end of humerus
5.5
6.6
18
34
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.2
6.5
23
57
SPAT1301
SPAT
No procedures
2.0
6.5
91
521
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.8
6.4
26
73
E801E
ICD-9 Finland
Railway accident involving collision with other object[MOOTTORIK AJON AIH TAPAT YL LIIKAL,POLKUPYÖR/KULJET]
71.1
6.4
7
*
PA2AD
NOMESCO Finland
CT angiography of brain
71.1
6.4
7
*
V14.2
ICD-10 Finland
Pedal cyclist injured in collision with heavy transport vehicle or bus, unspecified pedal cyclist injured in nontraffic accident
71.1
6.4
7
*
Y07
ICD-10 Finland
Other maltreatment
14.7
6.4
10
7
Z72.1
ICD-10 Finland
Alcohol use
8.4
6.4
13
16
G30.1
ICD-10 Finland
Alzheimer disease with late onset
11.3
6.3
11
10
A06AD11
ATC
lactulose; oral
2.7
6.3
43
172
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
18.4
6.3
9
5
ZXE00
NOMESCO Finland
One hour or less
1.9
6.3
118
752
F10.01
ICD-10 Finland
Alcohol-related acute intoxication with permanent or other somatic damage
+∞
6.3
6
*
G81.9
ICD-10 Finland
Hemiplegia, unspecified
+∞
6.3
6
*
S06.1
ICD-10 Finland
Traumatic cerebral oedema
+∞
6.3
6
*
I62.0
ICD-10 Finland
Nontraumatic subdural haemorrhage
+∞
6.3
6
*
F07.2
ICD-10 Finland
Postconcussional syndrome
+∞
6.3
6
*
G40.89
ICD-10 Finland
Other epilepsy
+∞
6.3
6
*
8524C
ICD-9 Finland
Subarachnoid, subdural and extradural haemorrhage, following injury, Extradural haemorrhage following injury without mention of open intracranial wound[HAEMORRHAGIA EPIDURALIS TR,ALLE TUNNIN TAJUTTOMUUS]
+∞
6.3
6
*
8524D
ICD-9 Finland
Subarachnoid, subdural and extradural haemorrhage, following injury, Extradural haemorrhage following injury without mention of open intracranial wound[HAEMORRHAGIA EPIDURALIS TR,1-24 TUNTIA TAJUTTOMUUS]
+∞
6.3
6
*
N05BA09
ATC
clobazam; oral
+∞
6.3
6
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
6.3
61
298
S02.70
ICD-10 Finland
Multiple fractures involving skull and facial bones, closed
27.2
6.3
8
*
N28
ICPC
Limited function/disability (N)
27.2
6.3
8
*
N03AX16
ATC
pregabalin; oral
2.3
6.2
57
272
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
6.2
80
442
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
4.3
6.1
21
51
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
8.8
6.1
12
14
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
8.8
6.1
12
14
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.4
6.1
53
245
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
6.2
6.1
15
25
U04
ICPC
Incontinence urine
6.2
6.1
15
25

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: ST19_EPIDU_HAEMORRHAGE – Epidural haemorrhage

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).