This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Problems related to physical environment
Z21_PROBL_RELATED_PHYSIC_ENVIRONMENT
No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
297 |
4. Check minimum number of eventsNone |
297 |
5. Include endpointsNone |
297 |
6. Filter based on genotype QC (FinnGen only) |
297 |
Control definitions (FinnGen only)
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Z5[5-9]|Z6
Similar endpoints
↥List of similar endpoints to
Problems related to physical environment
based on the number of shared cases.
Similar with more cases:
- Persons with potential health hazards related to socioeconomic and psychosocial circumstances
- Factors influencing health status and contact with health services
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 297 | 222 | 75 |
| Unadjusted period prevalence (%) | 0.06 | 0.08 | 0.03 |
| Median age at first event (years) | 44.36 | 43.45 | 47.06 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 248
- Matched controls
- 2479
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z58.8
ICD-10 Finland
Other problems related to physical environment
+∞
245.5
193
*
XQ800
NOMESCO Finland
Prick test
11.6
44.2
90
116
Z58.1
ICD-10 Finland
Exposure to air pollution
+∞
33.1
31
*
R03AC02
ATC
salbutamol; inhalant
4.6
26.1
191
1039
J45.1
ICD-10 Finland
Nonallergic asthma
8.5
25.4
59
88
J45.0
ICD-10 Finland
Predominantly allergic asthma
7.0
25.4
68
126
R03BA02
ATC
budesonide; inhalant
4.8
23.2
92
270
J31.0
ICD-10 Finland
Chronic rhinitis
7.0
22.3
59
106
R03DC03
ATC
montelukast; oral
4.3
20.0
87
274
J45.9
ICD-10 Finland
Asthma, unspecified
4.1
18.3
84
275
R03BA05
ATC
fluticasone; inhalant
4.0
17.9
85
286
J30.3
ICD-10 Finland
Other allergic rhinitis
10.8
17.6
34
36
S01GX01
ATC
cromoglicic acid; ophthalmic
3.7
16.8
90
332
R4110
NOMESCO Finland
Physiotherapy
3.5
16.7
101
410
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
6.4
15.2
41
74
R03AK06
ATC
salmeterol and fluticasone; inhalant
4.3
15.1
62
180
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
3.5
14.6
80
295
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
4.1
13.8
59
176
Z58.0
ICD-10 Finland
Exposure to noise
+∞
12.6
12
*
R06AX27
ATC
desloratadine; oral
2.7
11.5
106
539
R03AC03
ATC
terbutaline; inhalant
3.4
11.1
59
207
R01AD09
ATC
mometasone; nasal
2.5
10.8
145
897
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
6.1
10.7
29
53
R01AD08
ATC
fluticasone; nasal
2.6
10.6
105
549
R01AD05
ATC
budesonide; nasal
4.4
10.5
39
101
Z58.9
ICD-10 Finland
Problem related to physical environment, unspecified
+∞
10.5
10
*
R03BB04
ATC
tiotropium bromide; inhalant
4.5
9.9
35
87
R03AK07
ATC
formoterol and budesonide; inhalant
2.8
9.7
72
315
R06AX22
ATC
ebastine; oral
2.8
9.6
67
285
J45
ICD-10 Finland
Asthma
3.6
9.5
45
145
R03BA08
ATC
ciclesonide; inhalant
4.1
9.4
37
102
H10.4
ICD-10 Finland
Chronic conjunctivitis
16.4
9.1
14
9
T78.4
ICD-10 Finland
Allergy, unspecified
4.7
8.9
30
71
H02AB07
ATC
prednisone; oral
3.0
8.8
53
203
R06.0
ICD-10 Finland
Dyspnoea
2.6
8.6
71
331
R05
ICD-10 Finland
Cough
2.7
8.4
61
264
R03BB01
ATC
ipratropium bromide; inhalant
6.9
8.4
20
31
C01CA24
ATC
epinephrine; parenteral
3.9
8.2
33
93
R06AE07
ATC
cetirizine; oral
2.2
8.0
133
863
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
3.9
8.0
33
95
J01FA10
ATC
azithromycin; systemic
2.2
7.8
172
1255
R03AC13
ATC
formoterol; inhalant
4.8
7.5
24
54
J45.8
ICD-10 Finland
Mixed asthma
7.2
7.4
17
25
H02AB06
ATC
prednisolone; systemic
2.1
7.3
130
855
R06AX13
ATC
loratadine; oral
2.5
7.2
59
271
R06.2
ICD-10 Finland
Wheezing
5.5
7.1
20
39
J01FA06
ATC
roxithromycin; oral
2.1
7.0
118
755
J01FA09
ATC
clarithromycin; systemic
2.1
7.0
106
652
R96
ICPC
Asthma
3.5
6.9
32
102
R03BA01
ATC
beclometasone; inhalant
2.6
6.6
50
217
R03BC03
ATC
nedocromil; inhalant
3.4
6.6
31
100
N06AB04
ATC
citalopram; systemic
2.3
6.5
66
337
J30.0
ICD-10 Finland
Vasomotor rhinitis
5.8
6.4
17
31
K58
ICD-10 Finland
Irritable bowel syndrome
8.5
6.4
13
16
Z71.8
ICD-10 Finland
Other specified counselling
2.2
6.4
70
370
R01BA52
ATC
pseudoephedrine, combinations; oral
2.0
6.2
98
605
EB1AA
SPAT
NA
4.1
6.1
22
57
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
2.2
6.0
66
346
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
82
341
2.94
14.22
2.9
2.6
1.70
2.90
e6/l
1.17
31
179
183
1134
2.60
14.17
5.8
5.5
55.36
56.23
%
0.55
171
1071
184
1145
2.60
14.09
5.9
5.7
30.19
29.08
%
0.83
172
1080
59
221
3.08
12.17
3.9
2.2
33.00
33.51
u/l
0.04
48
188
82
368
2.70
12.12
3.0
2.5
0.37
0.86
e6/l
2.64
32
204
142
878
2.18
9.82
2.1
1.8
96.16
100.04
pmol/l
0.50
64
452
199
1406
2.26
9.81
7.4
9.4
3.87
3.99
e9/l
0.34
168
1240
80
391
2.43
9.68
2.6
2.6
2.41
2.45
mmol/l
2.30
66
350
57
273
2.35
7.06
2.8
2.2
5.24
8.85
umol/l
1.27
45
236
253
2095
2.40
6.90
20.2
14.4
13.54
13.59
%
0.13
247
2062
72
384
2.15
6.88
5.2
3.4
263.40
283.81
ng/l
0.03
52
271
17
43
4.13
6.26
1.4
1.1
—
—
—
0
0
17
43
4.13
6.26
1.4
1.1
—
—
—
0
0
151
1086
1.79
5.74
3.2
2.6
89.06
89.08
ug/l
0.00
143
1013
118
791
1.82
5.66
3.4
3.1
2.37
2.36
mmol/l
0.09
102
705
215
1742
1.85
5.26
4.5
3.1
—
—
—
0
0
96
622
1.80
5.05
3.4
2.7
0.09
0.36
e6/l
2.14
56
459
265
2324
2.30
4.91
20.4
12.4
40.70
40.39
%
0.60
246
1799
133
953
1.72
4.89
3.7
4.1
37.00
36.51
g/l
0.54
126
901
15
42
3.71
4.83
1.0
1.1
0.52
1.64
u/ml
—
7
15
84
533
1.80
4.69
2.2
1.6
1.17
0.93
mg/l
0.23
68
415
22
81
2.85
4.63
1.2
1.1
—
—
—
0
0
22
82
2.82
4.53
1.2
1.1
—
—
—
0
0
81
518
1.78
4.38
2.1
1.5
—
—
—
0
0
34
645
0.47
4.35
3.2
3.4
0.00
0.00
estimate
—
9
226
135
1001
1.64
4.18
5.8
5.0
1.21
1.22
mmol/l
0.60
127
914
24
99
2.55
4.09
6.7
5.7
24.36
25.45
mmol/l
0.78
24
99
51
291
1.91
3.94
2.1
1.9
29.29
29.22
s
0.03
51
283
19
71
2.79
3.90
1.7
1.1
—
—
—
0
0
91
620
1.67
3.87
2.6
2.6
6531.90
6143.63
umol/l
0.02
83
546
90
612
1.68
3.85
1.3
1.2
0.47
1.22
u/ml
1.59
12
180
12
34
3.64
3.80
2.1
1.5
—
—
—
0
0
136
1032
1.59
3.71
2.5
2.2
75.11
76.44
nmol/l
0.20
124
934
16
56
2.96
3.69
1.6
1.8
—
—
—
0
0
95
662
1.64
3.67
1.8
1.6
1.47
1.44
mmol/l
0.12
86
564
219
1863
1.67
3.67
4.3
4.0
11.12
10.54
mm/h
0.25
202
1729
18
68
2.75
3.63
1.1
1.2
—
—
—
0
0
18
68
2.75
3.63
1.9
1.3
—
—
—
0
0
40
216
1.98
3.62
2.3
1.8
—
—
—
0
0
230
1989
1.69
3.53
4.3
4.1
14.28
14.57
pmol/l
1.03
221
1828
20
84
2.48
3.30
1.8
1.9
7.06
7.40
g/l
0.23
15
66
20
84
2.48
3.30
1.8
1.9
3.34
3.94
g/l
1.20
15
62
20
84
2.48
3.30
1.8
1.9
—
—
—
0
0
263
2379
1.92
3.26
14.6
10.7
86.12
84.60
ml/min/173m2
0.64
206
1940
21
91
2.41
3.25
2.0
1.5
—
—
—
0
0
110
817
1.55
3.18
3.3
2.9
—
—
—
0
0
141
1107
1.52
3.15
6.6
5.8
1.22
1.22
mmol/l
0.60
127
948
38
212
1.91
3.14
2.3
1.7
—
—
—
0
0
215
1860
1.56
2.97
8.0
7.1
83.31
77.44
u/l
0.56
205
1744
18
76
2.46
2.95
1.7
1.3
338.18
331.17
ug/g
0.06
11
43
22
105
2.18
2.76
2.1
1.6
—
—
—
0
0
270
2490
1.93
2.75
17.2
11.6
21.44
20.18
mg/l
0.28
210
1927
6
10
6.10
2.71
1.0
1.0
—
—
—
0
0
9
25
3.68
2.59
1.0
1.2
—
—
—
0
0
9
25
3.68
2.59
1.0
1.2
—
—
—
0
0
5
7
7.24
2.56
1.2
1.0
95.00
101.00
%
—
5
7
5
7
7.24
2.56
1.2
1.0
—
—
—
0
0
73
517
1.55
2.55
1.5
1.3
13.26
33.38
iu/ml
2.91
15
182
9
26
3.54
2.50
1.0
1.2
—
—
—
0
0
9
26
3.54
2.50
1.0
1.2
—
—
—
0
0
9
26
3.54
2.50
1.0
1.2
—
—
—
0
0
69
485
1.55
2.49
1.5
1.4
20.92
22.41
nmol/l
0.43
62
411
28
153
1.92
2.48
1.4
1.4
—
—
—
0
0
202
1758
1.47
2.42
3.0
2.9
46.99
43.84
u/l
0.19
188
1664
256
2348
1.65
2.35
5.6
4.7
1.58
2.38
mu/l
0.94
247
2168
71
951
0.67
2.31
2.4
3.3
—
—
—
0
0
17
80
2.19
2.23
1.2
2.5
1.70
1.46
g/l
0.28
11
69
5
10
5.06
2.08
1.2
2.5
—
—
—
0
0
5
10
5.06
2.08
1.2
2.5
—
—
—
0
0
34
210
1.70
2.06
1.1
1.2
62.33
154.32
iu/ml
1.71
11
91
11
44
2.56
2.03
1.8
1.4
—
—
—
0
0
6
16
3.80
1.94
1.3
1.6
—
—
—
0
0
6
16
3.80
1.94
1.8
1.5
4.67
2.83
mg/l
—
6
16
46
313
1.56
1.91
2.7
1.8
—
—
—
0
0
149
1262
1.36
1.89
5.8
5.8
10.71
10.11
umol/l
0.41
140
1196
52
368
1.50
1.81
1.6
1.7
1022.55
1173.72
nmol/l
0.69
40
277
68
508
1.44
1.81
1.5
1.3
2.51
11.26
u/ml
2.93
18
217
8
29
2.81
1.80
1.0
1.2
—
—
—
0
0
73
553
1.42
1.80
2.4
2.0
—
—
—
0
0
42
287
1.54
1.72
2.0
1.7
—
—
—
0
0
14
69
2.08
1.67
1.2
1.2
390.36
427.95
mg/l
0.31
14
64
28
175
1.66
1.65
3.7
3.4
1.19
2.36
mmol/l
1.12
22
146
45
316
1.50
1.63
2.2
1.8
—
—
—
0
0
24
144
1.73
1.63
1.2
1.3
23.24
30.11
iu/l
0.57
19
123
35
235
1.55
1.56
6.1
5.5
104.63
104.06
mmol/l
0.32
35
227
27
170
1.65
1.55
2.6
2.4
66.22
67.90
g/l
0.52
22
157
7
27
2.63
1.52
1.3
1.1
—
—
—
0
0
6
21
2.89
1.51
1.0
1.0
—
—
—
0
0
245
2282
1.42
1.50
5.2
5.2
37.99
39.08
mmol/mol
1.47
235
2146
21
125
1.73
1.48
2.2
1.5
—
—
—
0
0
6
22
2.76
1.44
3.7
3.8
—
—
—
0
0
33
226
1.52
1.36
1.9
4.1
2.60
7.10
ug/l
2.01
23
184
23
145
1.64
1.33
1.1
1.0
—
—
—
0
0
18
290
0.60
1.32
5.4
5.6
—
—
—
0
0
6
25
2.43
1.25
1.0
1.1
—
—
—
0
0
6
25
2.43
1.25
1.0
1.0
—
—
—
0
0
9
45
2.03
1.24
1.3
1.3
—
—
—
0
0
8
37
2.19
1.22
1.4
1.3
—
—
—
0
0
24
158
1.56
1.19
2.8
1.6
—
—
—
0
0
0
34
0.00
1.16
0.0
1.6
—
—
—
0
0
5
20
2.52
1.15
1.0
1.0
—
—
—
0
0
0
36
0.00
1.14
0.0
2.9
—
55.49
—
0
36
6
125
0.47
1.07
6.3
3.6
1.37
1.61
mmol/l
—
6
92
136
1204
1.24
1.04
4.6
4.5
0.00
0.00
estimate
—
9
227
7
133
0.51
1.01
5.7
3.5
5.26
5.11
kpa
—
7
122
7
134
0.51
1.01
1.7
1.5
—
—
—
0
0
254
2421
1.34
0.99
4.6
4.3
5.89
5.84
mmol/l
0.22
238
2249
33
243
1.40
0.98
3.0
2.5
0.67
0.70
ug/l
0.11
22
146
7
36
1.97
0.97
1.0
1.1
—
—
—
0
0
0
32
0.00
0.95
0.0
1.1
—
—
—
0
0
31
230
1.39
0.89
2.4
2.0
378.83
355.61
nmol/l
0.21
24
208
73
859
0.80
0.89
3.5
3.3
11.66
34.89
ng/l
2.81
31
538
62
512
1.27
0.87
2.1
2.0
3.20
3.06
mg/l
0.09
47
438
135
1213
1.21
0.86
2.8
3.2
0.00
0.01
estimate
—
8
216
6
31
1.95
0.85
1.0
1.0
—
—
—
0
0
10
58
1.75
0.80
1.8
1.5
—
—
—
0
0
10
58
1.75
0.80
1.8
1.5
—
—
—
0
0
10
58
1.75
0.80
1.8
1.5
—
—
—
0
0
10
58
1.75
0.80
1.8
1.5
—
—
—
0
0
6
33
1.83
0.79
1.0
1.0
—
—
—
0
0
8
48
1.68
0.79
1.9
1.1
—
—
—
0
0
6
34
1.78
0.76
1.3
1.7
—
—
—
0
0
5
24
2.10
0.75
1.4
1.7
—
—
—
0
0
5
25
2.02
0.73
1.0
1.8
—
—
—
0
0
35
276
1.30
0.71
1.7
1.7
—
—
—
0
0
9
58
1.57
0.70
1.7
2.4
—
—
—
0
0
273
2654
1.35
0.70
17.1
13.5
69.01
71.93
umol/l
1.83
273
2654
12
77
1.58
0.69
1.5
1.8
1.98
6.42
iu/l
—
5
24
10
61
1.66
0.69
1.7
1.2
—
—
—
0
0
36
445
0.78
0.67
1.5
1.6
474.31
13263040.19
pmol/l
0.50
29
377
5
28
1.80
0.66
1.4
1.7
—
—
—
0
0
5
28
1.80
0.66
1.0
1.0
—
—
—
0
0
14
198
0.69
0.62
2.9
3.0
—
—
—
0
0
10
63
1.61
0.62
2.0
1.6
—
—
—
0
0
0
21
0.00
0.60
0.0
1.7
—
52.87
—
0
15
10
64
1.58
0.59
1.1
1.3
—
42.36
—
0
7
285
2798
1.46
0.58
22.6
17.6
4.47
4.51
e12/l
0.86
279
2738
6
35
1.73
0.58
2.0
1.7
—
—
—
0
0
16
115
1.41
0.58
1.7
2.1
3.12
2.62
mg/l
0.19
11
86
130
1201
1.15
0.53
2.9
3.2
0.00
0.00
estimate
—
6
225
6
98
0.60
0.53
2.0
3.4
68.08
50.80
%
—
6
98
261
2542
1.22
0.49
4.9
4.7
2.98
2.90
mmol/l
0.74
250
2375
273
2673
1.26
0.47
11.1
9.6
27.14
25.77
u/l
0.54
268
2586
7
48
1.47
0.47
1.4
2.0
—
—
—
0
0
7
48
1.47
0.47
1.6
1.3
—
104.50
—
0
10
5
83
0.60
0.46
4.8
2.1
—
—
—
0
0
7
51
1.38
0.44
2.1
1.7
—
—
—
0
0
39
333
1.20
0.43
3.5
4.1
21.29
21.34
%
0.01
13
145
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
63
566
1.14
0.39
2.4
2.9
730.51
728.01
ng/l
0.00
46
471
20
163
1.24
0.35
2.1
1.5
—
—
—
0
0
7
56
1.26
0.29
2.1
1.6
—
—
—
0
0
7
56
1.26
0.29
1.1
1.3
—
—
—
0
0
59
539
1.12
0.29
1.3
1.5
—
—
—
0
0
128
1338
0.92
0.25
5.3
3.9
6.28
6.54
mmol/l
0.85
120
1247
5
38
1.32
0.23
1.4
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
4.0
—
—
—
0
0
0
10
0.00
0.21
0.0
4.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
8.80
—
0
12
6
49
1.23
0.20
2.2
1.3
—
—
—
0
0
7
60
1.17
0.18
1.0
1.2
—
—
—
0
0
69
655
1.07
0.16
3.2
3.9
3.86
7.48
mg/mmol
0.90
40
391
18
200
0.89
0.13
1.9
2.6
86.30
69.94
ml/min/173m2
—
10
81
11
97
1.14
0.09
1.0
1.4
146.70
259.53
miu/ml
—
5
48
8
76
1.05
0.07
1.1
1.3
—
2.39
—
0
14
252
2503
1.04
0.06
4.1
4.3
4.93
4.86
mmol/l
0.52
239
2352
111
1129
0.97
0.06
3.5
3.6
—
—
—
0
0
11
118
0.93
0.03
1.3
1.4
—
—
—
0
0
12
113
1.06
0.02
1.4
1.5
—
—
—
0
0
240
2406
0.99
0.00
3.5
3.9
1.31
1.31
mmol/l
0.01
222
2248
11
107
1.03
0.00
1.9
1.5
—
—
—
0
0
249
2493
0.99
0.00
3.9
4.3
1.54
1.53
mmol/l
0.20
232
2329
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
10
100
1.00
0.00
1.0
1.7
—
—
—
0
0
5
56
0.89
0.00
1.2
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
5
59
0.84
0.00
3.0
4.0
—
4.21
—
0
5
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: Z21_PROBL_RELATED_PHYSIC_ENVIRONMENT – Problems related to physical environment
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).