No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
431 |
4. Check minimum number of eventsNone |
431 |
5. Include endpointsNone |
431 |
6. Filter based on genotype QC (FinnGen only) |
431 |
Control definitions (FinnGen only)
- Control exclude
- AB1_SEXUAL_TRANSMISSION
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Early syphilis
based on the number of shared cases.
Similar with more cases:
- Syphilis
- Infections with a predominantly sexual mode of transmission
- Certain infectious and parasitic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2515 | 815 | 1643 |
| Only index persons | 2222 | 742 | 1480 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.02 | 0.05 |
| Only index persons | 0.05 | 0.03 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 36.88 | 33.67 | 38.63 |
| Only index persons | 36.48 | 32.83 | 38.31 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 431 | 109 | 322 |
| Unadjusted period prevalence (%) | 0.12 | 0.04 | 0.14 |
| Median age at first event (years) | 39.13 | 32.48 | 41.38 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 376
- Matched controls
- 3759
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A51.0
ICD-10 Finland
Primary genital syphilis
+∞
152.8
136
*
Z11.3
ICD-10 Finland
Special screening examination for infections with a predominantly sexual mode of transmission
28.8
126.1
180
116
A51.3
ICD-10 Finland
Secondary syphilis of skin and mucous membranes
+∞
114.6
104
*
B23.1
ICD-10 Finland
HIV disease resulting in (persistent) generalized lymphadenopathy
193.7
99.7
100
7
A56.3
ICD-10 Finland
Chlamydial infection of anus and rectum
884.3
76.0
72
*
WW200
NOMESCO Finland
Immunization
29.3
70.9
97
44
A51.9
ICD-10 Finland
Early syphilis, unspecified
+∞
66.7
62
*
A56.0
ICD-10 Finland
Chlamydial infection of lower genitourinary tract
92.1
57.0
62
8
A54.5
ICD-10 Finland
Gonococcal pharyngitis
+∞
56.7
53
*
A54.6
ICD-10 Finland
Gonococcal infection of anus and rectum
+∞
56.7
53
*
Z21
ICD-10 Finland
Asymptomatic human immunodeficiency virus [HIV] infection status
532.1
48.5
47
*
B24
ICD-10 Finland
Unspecified human immunodeficiency virus [HIV] disease
187.1
48.1
49
*
A54.0
ICD-10 Finland
Gonococcal infection of lower genitourinary tract without periurethral or accessory gland abscess
+∞
46.9
44
*
09100
ICD-8 Finland
Early syphilis, symptomatic, Primary syphilis, except extragenital chancre
+∞
43.6
41
*
A63.0
ICD-10 Finland
Anogenital (venereal) warts
62.3
42.6
49
9
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
6.6
28.7
79
145
A53.9
ICD-10 Finland
Syphilis, unspecified
+∞
27.4
26
*
Y25
ICPC
Fear sexually transm disease male
10.6
26.2
52
56
Z29.2
ICD-10 Finland
Other prophylactic chemotherapy
255.6
23.9
24
*
A51.5
ICD-10 Finland
Early syphilis, latent
+∞
22.1
21
*
0913A
ICD-9 Finland
Early syphilis, symptomatic, Secondary syphilis of skin or mucous membranes
+∞
21.0
20
*
B23.8
ICD-10 Finland
HIV disease resulting in other specified conditions
210.6
19.7
20
*
09120
ICD-8 Finland
Early syphilis, symptomatic, Secondary syphilis of skin and mucous membranes
+∞
18.9
18
*
A60.0
ICD-10 Finland
Herpesviral infection of genitalia and urogenital tract
22.2
16.2
23
11
B23.0
ICD-10 Finland
Acute HIV infection syndrome
166.6
15.6
16
*
J05AB11
ATC
valaciclovir; oral
3.8
14.7
66
199
ZX114
NOMESCO Finland
Intramuscular
16.2
14.6
23
15
J01MA02
ATC
ciprofloxacin; systemic
2.4
14.0
161
889
Z25.1
ICD-10 Finland
Need for immunization against influenza
5.5
13.7
41
82
A56.4
ICD-10 Finland
Chlamydial infection of pharynx
78.0
13.7
15
*
TAB00
NOMESCO Finland
Lumbar puncture
5.8
13.1
37
69
J05AB01
ATC
aciclovir; systemic
2.9
12.5
87
359
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
2.7
12.2
94
413
D06BB04
ATC
podophyllotoxin; topical
4.6
11.9
42
101
A55
ICD-10 Finland
Chlamydial lymphogranuloma (venereum)
+∞
11.5
11
*
A51.4
ICD-10 Finland
Other secondary syphilis
+∞
10.5
10
*
A52.1
ICD-10 Finland
Symptomatic neurosyphilis
+∞
10.5
10
*
WNF00
NOMESCO Finland
Infection source and contact determination
+∞
10.5
10
*
Y71
ICPC
Gonorrhoea male
+∞
9.4
9
*
D11
ICPC
Diarrhoea
3.0
9.3
56
207
Z20.2
ICD-10 Finland
Contact with and exposure to infections with a predominantly sexual mode of transmission
6.4
9.1
23
38
K03.65
ICD-10 Finland
Deposits [accretions] on teeth betel
2.3
8.9
89
442
J01FA10
ATC
azithromycin; systemic
1.9
8.7
220
1589
0910A
ICD-9 Finland
Early syphilis, symptomatic, Genital syphilis (primary)
+∞
8.4
8
*
J01DB01
ATC
cefalexin; oral
2.2
8.1
311
2593
B37.4
ICD-10 Finland
Candidiasis of other urogenital sites
25.6
7.6
10
*
N06AX11
ATC
mirtazapine; oral
2.0
7.5
124
754
Z20.6
ICD-10 Finland
Contact with and exposure to human immunodeficiency virus [HIV]
+∞
7.3
7
*
A51.1
ICD-10 Finland
Primary anal syphilis
+∞
7.3
7
*
A52.9
ICD-10 Finland
Late syphilis, unspecified
+∞
7.3
7
*
Z03
ICD-10 Finland
Medical observation and evaluation for suspected diseases and conditions, ruled out
3.3
7.3
35
112
J01AA02
ATC
doxycycline; systemic
1.9
6.9
277
2253
Y70
ICPC
Syphilis male
71.0
6.4
7
*
N48.8
ICD-10 Finland
Other specified disorders of penis
14.6
6.4
10
7
P01AB01
ATC
metronidazole; oral, rectal
1.8
6.4
131
853
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
6.3
68
345
LEB00
NOMESCO Finland
Biopsy of vagina
18.4
6.3
9
5
A53.0
ICD-10 Finland
Latent syphilis, unspecified as early or late
+∞
6.3
6
*
A52.8
ICD-10 Finland
Late syphilis, latent
+∞
6.3
6
*
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
3.8
6.2
25
70
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
6.2
152
1049
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.3
6.0
55
258
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
192
117
28.79
244.51
10.4
1.5
—
—
—
0
0
196
146
23.79
225.42
10.6
1.6
—
—
—
0
0
122
21
80.64
224.63
14.5
8.7
1556.7
111.1
u/ml
—
70
8
101
25
52.46
171.41
2.6
3.2
27.9
38.9
%
—
10
9
127
5
358.60
132.17
3.7
1.8
—
—
—
0
0
83
30
34.03
125.74
2.1
2.0
852.0
634.6
e6/l
—
6
12
207
397
9.11
116.02
7.9
1.7
—
—
—
0
0
215
441
8.73
112.94
8.9
1.8
—
—
—
0
0
137
321
5.79
58.46
2.1
3.0
32.1
46.4
u/l
0.52
132
277
42
39
11.82
39.68
1.1
1.1
—
—
—
0
0
264
1595
2.69
21.86
11.4
6.1
52.9
57.1
%
6.90
256
1521
300
1939
2.80
21.56
12.3
9.4
3.8
4.1
e9/l
1.67
275
1694
265
1617
2.66
21.29
11.7
6.3
32.8
28.0
%
8.53
257
1539
231
1336
2.57
20.49
4.3
5.3
37.8
36.4
g/l
2.68
217
1266
47
108
4.76
19.47
1.2
1.4
232.1
241.5
miu/ml
0.05
18
58
174
915
2.51
18.44
1.9
1.7
1.4
1.5
mmol/l
1.35
166
778
42
93
4.90
18.16
2.6
1.5
—
—
—
0
0
272
1771
2.45
17.67
6.9
6.6
12.1
12.3
umol/l
0.08
263
1689
158
844
2.38
15.68
2.5
3.0
0.2
0.4
e6/l
1.08
105
628
112
517
2.58
15.22
1.9
2.7
0.8
0.9
e6/l
0.19
47
293
245
1589
2.26
15.14
3.2
3.0
0.0
0.0
estimate
0.00
22
279
206
1246
2.25
15.10
9.7
3.4
38.0
35.9
u/l
0.12
200
1186
25
41
6.41
14.82
1.0
1.1
—
—
—
0
0
244
1591
2.23
14.74
5.2
4.2
0.0
0.0
estimate
0.00
23
287
245
1604
2.22
14.60
3.3
3.1
0.0
0.0
estimate
0.50
20
263
185
1106
2.18
13.59
2.6
3.1
—
—
—
0
0
104
489
2.49
13.44
1.9
2.9
2.7
1.1
e6/l
0.48
39
266
333
2561
2.32
12.19
8.7
7.8
76.7
78.0
u/l
0.24
321
2432
42
129
3.50
11.69
1.6
1.4
—
—
—
0
0
19
33
5.98
10.62
1.9
1.8
—
—
—
0
0
264
1944
1.92
9.69
5.5
5.2
6.4
6.8
mmol/l
2.83
259
1840
390
3345
2.74
9.17
14.9
11.4
89.5
87.2
ml/min/173m2
1.45
329
2795
14
25
5.75
7.59
1.1
2.6
—
—
—
0
0
395
3504
2.52
6.92
13.8
12.9
26.8
23.7
mg/l
0.95
319
2748
38
164
2.44
5.77
1.9
1.2
—
—
—
0
0
29
112
2.70
5.51
1.8
2.9
1.2
1.4
mg/l
1.55
21
105
295
2445
1.65
5.47
4.0
3.7
11.1
10.3
mm/h
0.44
284
2282
367
3248
1.87
5.16
6.1
5.2
37.8
39.6
mmol/mol
0.92
351
3085
24
87
2.86
5.13
1.5
1.1
—
—
—
0
0
24
87
2.86
5.13
1.5
1.1
—
—
—
0
0
50
258
2.06
4.98
2.8
2.8
70.6
70.1
ml/min/173m2
0.03
24
112
46
232
2.10
4.86
1.7
1.9
40.4
36.4
nmol/l
0.51
46
227
11
24
4.68
4.80
4.1
2.4
—
—
—
0
0
9
12
7.63
4.37
3.4
2.1
—
—
—
0
0
172
1327
1.49
3.89
5.5
6.9
1.2
1.2
mmol/l
0.76
157
1232
7
8
8.87
3.78
1.0
1.0
—
—
—
0
0
77
508
1.63
3.47
2.4
2.3
14.7
14.2
nmol/l
0.21
71
470
20
82
2.51
3.43
2.0
1.4
28.4
19.1
e6/l
0.19
14
60
20
82
2.51
3.43
2.0
1.5
576.3
228.2
e6/l
0.43
14
62
368
3376
1.62
3.11
5.4
4.1
6.0
6.0
mmol/l
0.01
345
3152
91
643
1.53
3.05
1.5
1.5
21.9
20.5
nmol/l
0.44
82
559
104
758
1.49
3.00
2.1
2.4
—
—
—
0
0
32
171
1.94
2.95
1.0
1.0
—
—
—
0
0
7
13
5.45
2.88
1.3
1.4
29.1
27.5
umol/l
—
7
13
14
53
2.70
2.82
1.1
1.0
1.8
1.2
u/ml
—
6
24
91
658
1.49
2.72
1.9
1.4
—
—
—
0
0
23
113
2.09
2.67
1.3
1.6
0.0
0.1
iu/ml
—
10
21
6
11
5.51
2.55
6.2
1.9
—
—
—
0
0
6
11
5.51
2.55
2.3
2.1
—
—
—
0
0
8
21
3.86
2.47
1.3
1.0
—
—
—
0
0
12
45
2.71
2.47
1.6
1.1
—
—
—
0
0
9
27
3.38
2.40
1.6
1.4
1.1
1.0
g/l
—
9
27
403
3831
1.80
2.39
13.6
9.7
31.4
31.9
u/l
0.15
398
3727
18
84
2.19
2.38
2.8
1.7
—
—
—
0
0
367
3418
1.50
2.32
19.4
13.0
41.9
41.7
%
0.21
317
2715
139
1127
1.34
2.12
2.1
1.9
96.8
95.6
pmol/l
0.12
76
609
31
184
1.74
2.11
1.8
1.9
239.8
222.5
pmol/l
0.36
31
176
88
664
1.41
2.09
2.2
2.0
2.9
3.0
mg/l
0.16
77
580
176
1482
1.32
2.06
5.8
7.7
1.2
1.2
mmol/l
0.16
147
1286
121
970
1.34
1.98
3.3
3.6
2.4
2.4
mmol/l
0.32
101
864
6
16
3.79
1.94
1.2
1.0
—
—
—
0
0
14
65
2.19
1.90
1.7
1.6
—
—
—
0
0
8
28
2.89
1.87
1.3
1.3
—
—
—
0
0
15
73
2.09
1.82
1.0
1.2
—
—
—
0
0
68
504
1.41
1.79
3.4
3.0
2.4
2.4
mmol/l
0.01
55
442
45
308
1.51
1.77
2.0
2.5
0.2
0.2
g/l
0.22
40
285
7
24
2.95
1.73
1.0
1.0
—
—
—
0
0
375
3552
1.43
1.72
14.6
14.7
3.9
4.0
mmol/l
3.33
366
3476
274
2487
1.28
1.67
3.6
3.1
—
—
—
0
0
44
306
1.49
1.62
7.7
8.6
1.5
1.4
mmol/l
0.33
44
297
45
317
1.47
1.56
4.0
3.0
—
—
—
0
0
23
140
1.68
1.48
1.6
1.5
6.6
6.3
u/l
0.05
18
120
47
338
1.44
1.48
1.9
1.7
—
—
—
0
0
5
16
3.15
1.44
1.0
1.2
49.2
15.8
u/l
—
5
11
53
395
1.39
1.38
7.3
10.0
0.5
1.2
mmol/l
0.74
46
324
20
120
1.70
1.36
2.2
2.8
—
—
—
0
0
5
17
2.96
1.36
1.0
1.2
192.0
81.3
u/l
—
5
12
140
1199
1.25
1.34
2.4
2.3
79.2
74.4
nmol/l
0.95
123
1096
32
219
1.50
1.30
1.5
1.6
—
—
—
0
0
56
426
1.36
1.29
7.6
8.0
105.4
103.7
mmol/l
3.43
56
414
16
92
1.77
1.26
1.2
1.1
—
—
—
0
0
106
888
1.26
1.22
2.4
2.5
3559.5
6801.2
umol/l
0.42
96
791
88
722
1.27
1.20
1.4
1.2
0.6
1.4
u/ml
2.25
21
220
77
621
1.29
1.20
1.8
2.1
1.6
1.5
%
0.39
67
565
6
26
2.33
1.19
1.5
1.4
16100.0
31021.1
e6/l
—
6
16
6
26
2.33
1.19
1.7
1.0
—
—
—
0
0
6
26
2.33
1.19
1.7
1.0
—
—
—
0
0
8
38
2.13
1.19
3.1
1.8
—
—
—
0
0
46
346
1.37
1.15
1.9
1.8
—
—
—
0
0
7
30
2.35
1.13
1.3
1.1
—
—
—
0
0
261
2413
1.21
1.12
3.4
3.3
14.5
14.7
pmol/l
0.61
241
2212
5
21
2.40
1.09
2.6
2.6
—
—
—
0
0
165
1474
1.19
1.00
4.2
4.0
—
—
—
0
0
7
35
2.02
1.00
3.4
3.9
—
—
—
0
0
11
61
1.82
0.99
2.5
1.8
—
—
—
0
0
113
1298
0.82
0.99
3.3
3.3
22.7
37.8
ng/l
1.67
67
840
75
619
1.26
0.99
3.4
3.4
1583.9
676.4
ng/l
0.26
58
458
5
23
2.19
0.98
1.8
3.0
1030.0
762.4
u/ml
—
5
23
0
29
0.00
0.98
0.0
1.5
—
—
—
0
0
10
55
1.84
0.93
1.4
1.4
—
—
—
0
0
10
55
1.84
0.93
1.4
1.4
—
—
—
0
0
13
79
1.67
0.89
2.7
1.4
—
—
—
0
0
8
44
1.83
0.86
1.3
1.2
—
—
—
0
0
145
1296
1.18
0.86
2.6
2.6
153.4
157.9
ug/l
0.08
140
1217
19
129
1.49
0.85
1.6
2.3
99.4
668.9
ug/l
1.00
19
123
6
31
1.95
0.84
1.2
1.1
—
—
—
0
0
377
3651
1.26
0.84
6.0
4.5
2.9
2.9
mmol/l
0.01
355
3428
23
163
1.43
0.84
1.4
1.5
—
—
—
0
0
6
32
1.89
0.82
1.2
1.1
—
—
—
0
0
6
32
1.89
0.82
1.2
1.1
—
—
—
0
0
6
32
1.89
0.82
1.2
1.1
293.3
261.0
mg/l
—
6
25
6
32
1.89
0.82
1.2
1.1
—
—
—
0
0
6
32
1.89
0.82
1.2
1.1
—
—
—
0
0
6
32
1.89
0.82
1.2
1.1
—
—
—
0
0
52
422
1.26
0.80
1.7
2.5
27.3
24.7
%
0.44
47
376
11
66
1.68
0.79
2.9
3.8
—
3497.1
—
0
8
317
3026
1.18
0.79
4.2
3.9
1.8
2.3
mu/l
0.59
295
2810
0
26
0.00
0.78
0.0
1.8
—
3.2
—
0
13
5
24
2.10
0.74
1.2
1.3
—
—
—
0
0
7
38
1.86
0.74
1.1
1.3
—
—
—
0
0
15
100
1.52
0.74
1.2
1.2
—
—
—
0
0
9
59
1.54
0.68
1.1
1.1
—
—
—
0
0
5
27
1.86
0.68
1.4
1.3
32.4
49.2
u/l
—
5
17
5
27
1.86
0.68
2.0
2.6
—
—
—
0
0
10
64
1.58
0.59
3.3
4.1
52.8
56.7
%
—
10
64
8
53
1.52
0.58
3.1
1.5
—
—
—
0
0
25
194
1.31
0.57
1.3
1.4
—
—
—
0
0
57
488
1.19
0.57
1.9
1.8
—
—
—
0
0
6
36
1.68
0.57
1.8
1.4
—
—
—
0
0
370
3607
1.18
0.56
5.6
4.2
4.7
4.7
mmol/l
0.44
349
3408
13
182
0.71
0.55
4.5
2.5
0.6
0.1
e6/l
0.55
13
173
11
159
0.68
0.55
4.5
3.5
25.3
25.0
mmol/l
0.24
11
154
9
60
1.51
0.54
1.2
1.3
—
—
—
0
0
10
66
1.53
0.53
1.2
1.1
3.1
2.0
u/ml
—
5
30
14
100
1.41
0.52
1.5
2.0
—
—
—
0
0
84
751
1.15
0.50
1.8
1.8
1.0
1.1
mg/l
0.09
62
575
13
178
0.72
0.49
1.3
1.6
—
—
—
0
0
48
411
1.19
0.49
2.1
2.9
10.3
8.8
umol/l
0.15
40
369
7
47
1.50
0.47
3.7
1.6
—
—
—
0
0
8
118
0.67
0.46
1.5
1.6
—
—
—
0
0
60
527
1.16
0.46
1.4
1.2
43.2
29.9
iu/ml
0.38
18
161
16
209
0.76
0.46
3.5
3.3
122.4
132.4
g/l
0.92
16
204
104
954
1.12
0.43
3.7
4.2
17.3
9.1
mg/mmol
0.44
65
645
5
33
1.52
0.41
1.0
1.5
—
—
—
0
0
105
966
1.11
0.41
2.6
2.5
0.6
0.7
ug/l
0.98
77
519
0
16
0.00
0.41
0.0
3.8
—
75.6
—
0
16
12
88
1.37
0.40
8.1
6.1
—
264.6
—
0
14
15
193
0.77
0.40
2.5
3.4
1.9
1.8
mmol/l
—
10
146
0
19
0.00
0.39
0.0
1.3
—
1.0
—
0
8
356
3485
1.12
0.38
4.7
3.8
1.4
1.4
mmol/l
0.17
327
3278
10
72
1.40
0.37
1.2
1.2
—
—
—
0
0
11
81
1.37
0.36
1.0
1.3
—
—
—
0
0
120
1281
0.91
0.35
3.3
3.1
—
—
—
0
0
6
44
1.37
0.34
1.3
1.4
—
—
—
0
0
14
109
1.29
0.34
1.4
2.1
—
—
—
0
0
31
358
0.86
0.32
4.6
4.1
27.7
29.9
%
0.36
20
255
7
52
1.35
0.31
1.4
1.7
—
—
—
0
0
11
84
1.32
0.30
2.5
1.7
—
—
—
0
0
32
366
0.86
0.30
4.7
7.1
—
—
—
0
0
7
55
1.28
0.30
1.0
1.1
—
—
—
0
0
90
837
1.10
0.30
3.5
3.3
0.0
0.0
estimate
0.69
19
276
365
3593
1.10
0.28
5.6
4.1
1.3
1.4
mmol/l
1.85
340
3378
55
501
1.11
0.27
1.2
1.2
13.7
8.1
u/ml
0.18
27
220
8
65
1.24
0.27
3.4
1.6
—
—
—
0
0
5
72
0.69
0.26
1.6
1.3
—
—
—
0
0
11
87
1.27
0.24
2.5
1.7
—
—
—
0
0
263
2694
0.94
0.24
3.2
3.2
49.3
51.9
u/l
0.20
248
2556
11
88
1.26
0.22
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
0.4
—
0
6
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
12
0.00
0.21
0.0
1.3
—
119.3
—
0
12
0
13
0.00
0.21
0.0
1.3
—
9.7
—
0
13
10
80
1.26
0.20
1.7
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
3.8
—
—
—
0
0
0
14
0.00
0.20
0.0
3.8
—
—
—
0
0
10
121
0.82
0.18
1.5
1.9
—
—
—
0
0
7
63
1.11
0.17
1.1
1.2
11.5
17.1
u/l
—
7
56
8
71
1.13
0.16
1.3
1.4
—
—
—
0
0
124
1283
0.95
0.15
3.2
3.4
22.6
21.2
%
0.36
48
484
22
244
0.90
0.15
2.2
2.4
—
23.3
—
0
19
15
171
0.87
0.15
1.9
2.6
1.4
1.4
%
0.01
15
171
21
189
1.12
0.14
1.3
1.1
30.4
96.0
iu/ml
—
6
76
165
1620
1.03
0.09
4.4
3.7
3.1
1.8
ug/l
0.65
151
1479
6
57
1.05
0.08
1.5
1.7
—
—
—
0
0
10
113
0.88
0.08
1.1
2.1
10.0
11.5
mg/l
—
10
106
7
67
1.05
0.08
2.1
1.7
—
—
—
0
0
7
68
1.03
0.08
1.4
1.1
—
—
—
0
0
61
590
1.04
0.07
1.4
1.7
420.7
439.1
pmol/l
0.26
54
516
108
1102
0.97
0.06
2.8
2.8
63.3
57.2
u/l
0.36
98
1037
27
259
1.05
0.04
1.3
1.4
—
—
—
0
0
80
814
0.98
0.04
2.7
3.1
1068.8
976.3
ng/l
0.14
69
683
44
452
0.97
0.04
2.0
1.8
—
—
—
0
0
47
482
0.97
0.03
1.6
1.7
1080.2
1220.5
nmol/l
0.56
33
382
35
341
1.03
0.02
9.4
10.9
126.3
124.6
g/l
0.20
35
325
21
217
0.97
0.01
7.1
9.5
24.9
24.9
mmol/l
0.04
21
200
11
107
1.03
0.00
4.7
4.2
3.7
3.9
mmol/l
0.37
11
101
5
49
1.02
0.00
1.4
1.1
—
—
—
0
0
6
67
0.89
0.00
1.5
1.4
—
—
—
0
0
5
50
1.00
0.00
1.4
1.1
—
—
—
0
0
7
69
1.01
0.00
1.0
1.1
—
22.1
—
0
16
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
0.00
1.4
1.4
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
9
0.00
0.00
0.0
1.1
—
113.7
—
0
9
0
7
0.00
0.00
0.0
2.7
—
52.5
—
0
7
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
0.4
—
0
5
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
150.3
—
0
8
0
7
0.00
0.00
0.0
1.1
—
1.3
—
0
7
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
4.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint AB1_EARLY_SYPHILIS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_EARLY_SYPHILIS | 1.498 [1.19, 1.88] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 80 out of 997 males with AB1_EARLY_SYPHILIS died.
Mortality risk
Mortality risk for people of age
years, who have AB1_EARLY_SYPHILIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.299% |
| 5 | No data | 1.658% |
| 10 | No data | 4.176% |
| 15 | No data | 7.743% |
| 20 | No data | 12.609% |
Relationships between endpoints
↥Index endpoint: AB1_EARLY_SYPHILIS – Early syphilis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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