Postdysenteric arthropathy

ARTRHO_POSTDYSENTERIC

reactive arthritis: Reactive arthritis (ReA) is an autoimmune disorder belonging to the group of seronegative spondyloarthropathies and is characterized by the classic triad of arthritis, urethritis and conjunctivitis.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M02.1 Cause of death: ICD-10 — M02.1 2 out of 7 registries used, show all original rules.	345
4. Check minimum number of events None	345
5. Include endpoints None	345
6. Filter based on genotype QC (FinnGen only)	345

Control definitions (FinnGen only)

Control exclude: RHEUMA_ARHTROPAT_REACTIVE

Extra metadata

First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M02
Name in latin: Arthropathia post infectionem intestinalem

NAME	ARTRHO_POSTDYSENTERIC
CONTROL_EXCLUDE	RHEUMA_ARHTROPAT_REACTIVE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M021
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M021
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Postdysenteric arthropathy based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2221	1079	1138
Only index persons	2145	1048	1097
Unadjusted period prevalence (%)
Whole population	0.03	0.03	0.03
Only index persons	0.04	0.04	0.04
Median age at first event (years)
Whole population	45.19	45.69	44.72
Only index persons	44.97	45.57	44.40

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	345	182	163
Unadjusted period prevalence (%)	0.07	0.06	0.07
Median age at first event (years)	46.89	46.34	47.50

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
317: Matched controls
3169

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M02.1

ICD-10 Finland

Postdysenteric arthropathy

+∞

323.0

316

M02.9

ICD-10 Finland

Reactive arthropathy, unspecified

502.0

108.3

102

A07EC01

ATC

sulfasalazine; oral, rectal

20.3

91.9

149

132

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

13.4

70.0

136

168

M13.9

ICD-10 Finland

Arthritis, unspecified

14.7

56.2

100

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

12.8

50.2

102

H02AB06

ATC

prednisolone; systemic

5.7

44.5

230

1004

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

9.7

43.3

136

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

11.0

41.9

102

M02.8

ICD-10 Finland

Other reactive arthropathies

151.9

38.7

J01MA02

ATC

ciprofloxacin; systemic

3.6

25.3

171

778

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

9.5

20.2

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

10.4

19.8

P01BA02

ATC

hydroxychloroquine; oral

5.9

19.4

113

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

10.6

19.0

H20.0

ICD-10 Finland

Acute and subacute iridocyclitis

7.9

17.2

L88

ICPC

Rheumatoid/seropositive arthritis

10.7

17.1

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

3.4

15.4

321

M45

ICD-10 Finland

Ankylosing spondylitis

10.5

15.0

H02AB07

ATC

prednisone; oral

3.7

13.0

192

A02BC02

ATC

pantoprazole; systemic

2.4

11.9

217

1509

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

2.5

11.6

111

557

M46.9

ICD-10 Finland

Inflammatory spondylopathy, unspecified

11.8

11.2

L04AB06

ATC

golimumab; parenteral

22.4

10.8

L04AB04

ATC

adalimumab; parenteral

8.1

10.1

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

2.2

10.1

132

763

M00.9

ICD-10 Finland

Pyogenic arthritis, unspecified

14.0

9.8

N02AX02

ATC

tramadol; systemic, rectal

2.1

9.3

142

869

NA6BG

NOMESCO Finland

Sacro-iliac joint MRI examination with high intensity magnet

9.5

9.1

S01BA04

ATC

prednisolone; ophthalmic (corticosteroids, plain)

9.5

9.1

M13.1

ICD-10 Finland

Monoarthritis, not elsewhere classified

20.7

8.5

A02.0

ICD-10 Finland

Salmonella enteritis

20.7

8.5

M02.3

ICD-10 Finland

Reiter disease

+∞

8.4

ZXX01

NOMESCO Finland

Extent of proceudre, 1 unit

15.0

8.3

M06.0

ICD-10 Finland

Seronegative rheumatoid arthritis

6.2

7.8

4AB02

NOMESCO Finland

46.1

7.7

M25.5

ICD-10 Finland

Pain in joint

2.1

7.6

107

621

M01AE02

ATC

naproxen; oral, rectal

1.9

7.5

189

1370

A04.5

ICD-10 Finland

Campylobacter enteritis

13.8

7.4

M03.2*A04.6

ICD-10 Finland

Postinfectious arthropathy in enteritis due to Yersinia enterocolitica

+∞

7.3

TNG10

NOMESCO Finland

Puncture of knee

12.4

7.1

M46.1

ICD-10 Finland

Sacroiliitis, not elsewhere classified

8.6

6.9

S01BA01

ATC

dexamethasone; ophthalmic (corticosteroids, plain)

4.2

6.7

M06.9

ICD-10 Finland

Rheumatoid arthritis, unspecified

5.7

6.7

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

3.0

6.7

138

M01AH01

ATC

celecoxib; oral (coxibs)

2.3

6.6

320

M01AC06

ATC

meloxicam; systemic, rectal

1.9

6.6

118

749

M01AH05

ATC

etoricoxib; oral

1.8

6.3

194

1470

H20.1

ICD-10 Finland

Chronic iridocyclitis

18.5

6.3

TNX00

NOMESCO Finland

Puncture and needle biopsy of soft tissue, unspecified region

6.5

6.2

M05.8

ICD-10 Finland

Other seropositive rheumatoid arthritis

3.8

6.1

L04AB01

ATC

etanercept; parenteral

6.9

6.1

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.0

6.0

489

Mortality – FinRegistry

↥

Association

Association between endpoint ARTRHO_POSTDYSENTERIC and mortality.

Females

Parameter	HR [95% CI]	p-value
ARTRHO_POSTDYSENTERIC	1.182 [0.9, 1.55]	0.228
Birth year	0.999 [0.99, 1.01]	0.765

During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 974 females with ARTRHO_POSTDYSENTERIC died.

Males

Parameter	HR [95% CI]	p-value
ARTRHO_POSTDYSENTERIC	0.814 [0.65, 1.02]	0.071
Birth year	0.986 [0.98, 1.0]	0.007

During the follow-up period (1.1.1998 — 31.12.2019), 80 out of 1010 males with ARTRHO_POSTDYSENTERIC died.

Mortality risk

Mortality risk for people of age

years, who have ARTRHO_POSTDYSENTERIC.

N-year risk	Females	Males
1	0.104%	0.138%
5	0.787%	0.85%
10	1.998%	2.199%
15	3.78%	4.239%
20	6.482%	7.309%

Relationships between endpoints

↥

Index endpoint: ARTRHO_POSTDYSENTERIC – Postdysenteric arthropathy

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Postdysenteric arthropathy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints