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Malignant neoplasm of floor of mouth, excluding all cancers (controls excluding all cancers)

C3_FLOOROFMOUTH_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C04
  • Hospital discharge: ICD-9 144
  • Hospital discharge: ICD-8 144
  • Cause of death: ICD-10 C04
  • Cause of death: ICD-9 144
  • Cause of death: ICD-8 144
  • Cancer registry: Topography ICD-O-3 C04
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

297

4. Check minimum number of events

None

297

5. Include endpoints

None

297

6. Filter based on genotype QC (FinnGen only)

297

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of floor of mouth, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 297 106 191
Unadjusted period prevalence (%) 0.07 0.04 0.08
Median age at first event (years) 63.00 62.21 63.44

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
154
Matched controls
1538
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8070/3-C04.9
ICD-O-3
Squamous cell carcinoma, NOS, of floor of mouth, NOS
+∞
117.1
97
*
C04.0
ICD-10 Finland
Malignant neoplasm: Anterior floor of mouth
+∞
100.2
85
*
EJB30
NOMESCO Finland
Excision of lesion of floor of mouth
+∞
86.9
75
*
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
143.5
84.8
85
13
130
Kela drug reimbursment
Malignant tumour
+∞
75.3
66
*
GBB00
NOMESCO Finland
Tracheostomy
119.9
66.0
68
10
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
236.7
60.9
59
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
155.1
51.6
52
5
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
49.7
45
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
15.0
49.5
109
214
C04.1
ICD-10 Finland
Malignant neoplasm: Lateral floor of mouth
+∞
48.5
44
*
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
+∞
47.4
43
*
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
492.8
40.0
38
*
ZZQ00
NOMESCO Finland
Free microvascular graft of skin
+∞
38.1
35
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
12.9
36.1
72
98
C04.9
ICD-10 Finland
Malignant neoplasm: Floor of mouth, unspecified
+∞
34.7
32
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
24.1
34.5
50
30
EDB00
NOMESCO Finland
Partial excision of mandible
420.0
34.3
33
*
XX3DW
NOMESCO Finland
Time consuming IT work
25.7
32.6
46
25
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
86.3
31.4
34
5
SAA03
NOMESCO Finland
Extended examination of mouth
7.5
29.6
105
342
C04.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of floor of mouth
+∞
29.1
27
*
SBB10
NOMESCO Finland
Teeth copy
21.6
28.9
43
27
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
18.2
27.7
44
33
A07AA02
ATC
nystatin; oral
17.1
26.5
43
34
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
70.7
26.0
29
5
C03.1
ICD-10 Finland
Malignant neoplasm: Lower gum
+∞
25.7
24
*
A03FA01
ATC
metoclopramide; systemic, rectal
10.2
25.2
54
77
EJB60
NOMESCO Finland
Partial excision of floor of mouth
+∞
24.6
23
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
24.6
23
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
281.9
24.4
24
*
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
56.5
24.3
28
6
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
23.5
22
*
N02AA05
ATC
oxycodone; systemic
9.1
23.4
54
86
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
141.0
23.3
24
*
EBA15
NOMESCO Finland
Extraction of large number of teeth
18.5
22.5
35
24
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
19.5
22.3
34
22
8070/3-C04.0
ICD-O-3
Squamous cell carcinoma, NOS, of anterior floor of mouth
+∞
20.2
19
*
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
24.1
19.9
28
14
EBB10
NOMESCO Finland
Insertion of dental implant
53.6
19.8
23
5
H02AB02
ATC
dexamethasone; systemic
40.2
19.6
24
7
WF002
NOMESCO Finland
Radical radiotherapy
+∞
19.1
18
*
C02.11
ICD-10 Finland
Malignant neoplasm of border of tongue
+∞
19.1
18
*
ZZA00
NOMESCO Finland
Split skin graft
35.1
19.0
24
8
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
215.0
19.0
19
*
WX408
NOMESCO Finland
General anesthesy, balanced
5.4
18.6
68
195
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
26.8
18.4
25
11
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
15.9
18.4
30
23
ECA20
NOMESCO Finland
Biopsy of gingiva
107.6
18.0
19
*
K08.2
ICD-10 Finland
Atrophy of edentulous alveolar ridge
107.6
18.0
19
*
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prothetic work
14.0
17.5
30
26
EBB15
NOMESCO Finland
Insertion of dental implant abutment
71.6
17.2
19
*
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
31.7
17.0
22
8
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
+∞
17.0
16
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
17.0
16
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
8.7
16.5
37
54
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.3
16.5
59
162
TJD20
NOMESCO Finland
Change of gastrostomy tube
177.1
15.8
16
*
EBA10
NOMESCO Finland
Surgical removal of tooth
7.6
15.8
39
66
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
17.5
15.5
24
16
Z51.5
ICD-10 Finland
Palliative care
17.8
15.0
23
15
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
88.7
14.9
16
*
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
+∞
14.8
14
*
SPA20
NOMESCO Finland
Selection and insertion of implantdistans
+∞
14.8
14
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
14.8
14
*
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
+∞
13.7
13
*
YA1CD
NOMESCO Finland
Very extensive CT examination of head and neck for dose design of radiotherapy
+∞
13.7
13
*
SXC03
NOMESCO Finland
Other oral or dental procedure
28.8
13.7
18
7
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
152.8
13.7
14
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
152.8
13.7
14
*
K13.78
ICD-10 Finland
Other change in the oral mucosa
17.1
13.5
21
14
UDQ12
NOMESCO Finland
Flexible laryngoscopy
10.5
13.4
26
29
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
55.0
13.1
15
*
SCA02
NOMESCO Finland
Analysis and advice of nutrition with regard to dentistry
7.3
13.0
32
53
K13.29
ICD-10 Finland
Indefinite leukoplakia
35.4
12.8
16
5
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
35.4
12.8
16
5
8070/3-C04.1
ICD-O-3
Squamous cell carcinoma, NOS, of lateral floor of mouth
+∞
12.7
12
*
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
+∞
12.7
12
*
K10.26
ICD-10 Finland
Periostitis of jaw (acute)(chronic)(suppurative)
+∞
12.7
12
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
12.7
12
*
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
+∞
12.7
12
*
SXC05
NOMESCO Finland
Other oral or dental procedure
10.1
12.6
25
29
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
3.5
12.2
86
409
SPF00
NOMESCO Finland
Repatation of teeth prosthesis
16.5
12.2
19
13
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
50.9
12.1
14
*
A04AA01
ATC
ondansetron; systemic, rectal
16.8
11.6
18
12
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
+∞
11.6
11
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
11.6
11
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
11.6
11
*
EJC99
NOMESCO Finland
Other reconstructive operations on tongue and floor of mouth
+∞
11.6
11
*
WX402
NOMESCO Finland
General anaesthesia
4.9
11.5
40
102
SAA04
NOMESCO Finland
Special inverstigation of mouth
7.8
11.3
26
39
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
7.0
11.3
28
47
ZXE40
NOMESCO Finland
More than seven and less than nine hours
19.6
11.0
16
9
GD1AD
NOMESCO Finland
Thorax CT examination
10.4
10.9
21
23
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
117.6
10.6
11
*
EJW99
NOMESCO Finland
Other operation on tongue or floor of mouth
117.6
10.6
11
*
SPD05
NOMESCO Finland
Demanding fitting of total teeth prosthesis
117.6
10.6
11
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
10.5
10
*
A04AD12
ATC
aprepitant; systemic
+∞
10.5
10
*
JCW98
NOMESCO Finland
Other transluminal endoscopic procedure on oesophagus
+∞
10.5
10
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
10.5
10
*
QAB05
NOMESCO Finland
Revision of wound of skin of head or neck
+∞
10.5
10
*
C03.0
ICD-10 Finland
Malignant neoplasm: Upper gum
+∞
10.5
10
*
PJD51
NOMESCO Finland
Block dissection of cervical lymph nodes
+∞
10.5
10
*
UJC01
NOMESCO Finland
Scopy of lower throat
35.2
10.5
13
*
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
25.4
10.4
14
6
SPF10
NOMESCO Finland
Demanding repatation of teeth prosthesis
14.5
10.4
17
13
R4190
NOMESCO Finland
Nutritional therapy
13.5
10.1
17
14
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
10.7
10.1
19
20
EKA10
NOMESCO Finland
Biopsy of cheek
13.6
9.6
16
13
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
32.3
9.5
12
*
EB1WA
NOMESCO Finland
NA
106.2
9.5
10
*
WZC30
NOMESCO Finland
Teaching
5.6
9.5
28
59
ZZQ20
NOMESCO Finland
Free microvascular graft of skin, muscle and bone
+∞
9.5
9
*
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
+∞
9.5
9
*
EJB99
NOMESCO Finland
Other excision on tongue and floor of mouth
+∞
9.5
9
*
OAB73
NOMESCO Finland
Prevention and treatment of malnutrition
+∞
9.5
9
*
K10.20
ICD-10 Finland
Osteomyelitis (neonatal) of jaw (acute)(chronic)(suppurative)
+∞
9.5
9
*
GD6AD
NOMESCO Finland
CT of chest and neck
+∞
9.5
9
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
9.5
9
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
7.4
9.4
22
34
R13
ICD-10 Finland
Dysphagia
6.1
9.3
25
47
WX110
NOMESCO Finland
Local anesthesy
3.1
9.2
114
743
SBA00
NOMESCO Finland
Microbiological examinations
13.7
9.1
15
12
EBA00
NOMESCO Finland
Extraction of tooth
3.0
8.9
66
305
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
7.8
8.9
20
29
ZZR00
NOMESCO Finland
Flap of skin
53.0
8.8
10
*
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
12.6
8.8
15
13
SXA10
NOMESCO Finland
Epithel biopsy of mouth
17.6
8.7
13
8
SPF20
NOMESCO Finland
Temporary soling for filling
29.4
8.6
11
*
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
9.4
8.6
17
20
J02AC01
ATC
fluconazole; systemic
3.0
8.5
64
298
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
95.0
8.5
9
*
EJB10
NOMESCO Finland
Excision of lesion of apex or body of tongue
95.0
8.5
9
*
K13.28
ICD-10 Finland
Other leukoplakia or disorder of epithelium of the palate or tongue
+∞
8.4
8
*
C01
ICD-10 Finland
Malignant neoplasm of base of tongue
+∞
8.4
8
*
EDB20
NOMESCO Finland
Hemimandibulectomy
+∞
8.4
8
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
8.4
8
*
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
+∞
8.4
8
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
+∞
8.4
8
*
SPF30
NOMESCO Finland
Soling for prothesis
12.7
8.3
14
12
ECB20
NOMESCO Finland
Oral alveoplasty
23.5
8.1
11
5
N05AA02
ATC
levomepromazine; systemic
8.5
8.1
17
22
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
8.1
84
475
N07BA03
ATC
varenicline; oral
5.8
7.9
22
43
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
8.8
7.8
16
20
D83
ICPC
Mouth/tongue/lip disease
47.4
7.8
9
*
K12.2
ICD-10 Finland
Cellulitis and abscess of mouth
47.4
7.8
9
*
SPD00
NOMESCO Finland
Fitting and preparation of total teeth prosthesis
19.6
7.7
11
6
SPD01
NOMESCO Finland
Mucosa-supported complete denture
26.5
7.7
10
*
EDW99
NOMESCO Finland
Other operation on mandible
83.9
7.5
8
*
D10.2
ICD-10 Finland
Benign neoplasm: Floor of mouth
83.9
7.5
8
*
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
10.1
7.5
14
15
EDC42
NOMESCO Finland
Mandibular repair with implant
+∞
7.3
7
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
7.3
7
*
C06.9
ICD-10 Finland
Malignant neoplasm: Mouth, unspecified
+∞
7.3
7
*
EJB40
NOMESCO Finland
Hemiglossectomy
+∞
7.3
7
*
D37.08
ICD-10 Finland
Tumor of uncertain or unknown nature in other part of lip, oral cavity and pharynx
31.6
7.2
9
*
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
7.6
7.2
16
23
SAA02
NOMESCO Finland
Basic examination of mouth
2.5
7.2
95
598
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.3
7.1
38
138
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
14.7
7.0
11
8
WX872
NOMESCO Finland
Intensive care
5.1
6.9
21
46
JN4BD
NOMESCO Finland
Extensive body CT
5.7
6.9
19
37
D20
ICPC
Mouth/tongue/lip symptom/complaint
7.0
6.8
16
25
Z2446
NOMESCO Finland
Social worker
7.0
6.8
16
25
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
6.4
6.8
17
29
WX707
NOMESCO Finland
Fiberoscopic intubation
41.9
6.8
8
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.6
6.7
66
349
R4130
NOMESCO Finland
Speech therapy
9.3
6.7
13
15
N02AX02
ATC
tramadol; systemic, rectal
2.4
6.5
79
467
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
15.1
6.5
10
7
SPA10
NOMESCO Finland
Setting attachments on tooth or implanted bracket or imblant based structures
72.7
6.5
7
*
EHA10
NOMESCO Finland
Biopsy of palate
72.7
6.5
7
*
JDB00
NOMESCO Finland
Gastrostomy
72.7
6.5
7
*
QAB10
NOMESCO Finland
Major dressing of wound of skin of head or neck
72.7
6.5
7
*
PJD91
NOMESCO Finland
Excision of lymph nodes in neck, 1 to 2 areas in total
72.7
6.5
7
*
F10.20
ICD-10 Finland
Alcohol dependence currently independent
9.9
6.4
12
13
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
11.7
6.4
11
10
L03AA02
ATC
filgrastim; parenteral
27.9
6.3
8
*
SBB20
NOMESCO Finland
Tooth X-ray examination in conjunction with visit to dentist
27.9
6.3
8
*
EDA10
NOMESCO Finland
Biopsy of mandible
+∞
6.3
6
*
SCB02
NOMESCO Finland
Training for mouth care at home
+∞
6.3
6
*
ZZQ10
NOMESCO Finland
Free microvascular graft of skin and muscle
+∞
6.3
6
*
EB1JA
NOMESCO Finland
Double panorama tomography of teeth and jaws or similar X-ray examination
+∞
6.3
6
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
6.3
6
*
Z43.1
ICD-10 Finland
Attention to gastrostomy
+∞
6.3
6
*
C06.0
ICD-10 Finland
Malignant neoplasm: Cheek mucosa
+∞
6.3
6
*
K05.31
ICD-10 Finland
Periodontitis pronounced
3.4
6.3
30
101
SCA03
NOMESCO Finland
Preventive oral health care, extensive
8.2
6.3
13
17
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.2
6.2
23
62
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
9.2
6.2
12
14
TPH07
NOMESCO Finland
Cathetrisation of artery
3.7
6.2
26
79
SAA01
NOMESCO Finland
Simple examination of mouth
2.4
6.1
107
749
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.5
6.0
28
92
TPH04
NOMESCO Finland
Cathetrisation of vein
2.8
6.0
41
176

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_FLOOROFMOUTH_EXALLC – Malignant neoplasm of floor of mouth, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).