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Benign neoplasm: Bronchus and lung

DOID EFO Endpoint Browser PheWeb

CD2_BENIGN_BRONCHUS_LUNG

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D14.3&
  • Hospital discharge: ICD-9 — 2123
  • Hospital discharge: ICD-8 — 2123
  • Cause of death: ICD-10 — D14.3&
  • Cause of death: ICD-9 — 2123
  • Cause of death: ICD-8 — 2123

2 out of 7 registries used, show all original rules.

480

4. Check minimum number of events

None

480

5. Include endpoints

None

480

6. Filter based on genotype QC (FinnGen only)

465

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D14
Name in latin
Neoplasma benignum bronchi

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3012 1351 1630
Only index persons 2312 1123 1189
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.05
Only index persons 0.04 0.04 0.05
Median age at first event (years)
Whole population 57.62 56.60 58.38
Only index persons 56.62 55.59 57.59

-FinnGen-

Key figures

All Female Male
Number of individuals 465 200 265
Unadjusted period prevalence (%) 0.10 0.07 0.12
Median age at first event (years) 58.37 54.61 61.22

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
480
Matched controls
4800
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D14.3
ICD-10 Finland
Benign neoplasm: Bronchus and lung
+∞
307.7
374
*
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
43.4
280.4
181
66
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
22.1
274.1
287
302
UGC12
NOMESCO Finland
Flexible bronchoscopy
8.2
85.9
138
226
GDB11
NOMESCO Finland
Thoracoscopic wedge resection of lung
132.4
83.1
87
8
2123A
ICD-9 Finland
Benign neoplasm of respiratory and intrathoracic organs, Bronchus and lung
+∞
82.7
77
*
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
14.1
46.6
44
34
GDA21
NOMESCO Finland
Thoracoscopic excision of lesion of lung
253.7
45.8
46
*
GDA20
NOMESCO Finland
Excision of lesion of lung
480.2
45.0
44
*
21230
ICD-8 Finland
Benign neoplasm of respiratory system, Bronchus and lung
+∞
35.9
34
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.5
30.9
140
511
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
5.3
28.0
60
125
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
7.5
27.6
41
59
GD1AD
NOMESCO Finland
Thorax CT examination
4.9
26.6
64
147
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
10.0
26.5
31
33
GDB21
NOMESCO Finland
Thoracoscopic segmental resection of lung
98.9
25.9
28
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.6
24.6
63
152
5823
FHL
Lung avobiopsy and wedge resection
87.8
22.9
25
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
4.9
22.5
52
115
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
20.2
274
1692
WX402
NOMESCO Finland
General anaesthesia
2.5
15.8
124
588
7931A
ICD-9 Finland
Nonspecific abnormal findings on radiological and other examination of body structure, Lung field
27.4
15.7
21
8
5822
FHL
Exploratory thoracotomy and small procedure (eg lung suture)
165.2
15.6
16
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.0
14.1
70
261
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.6
12.7
81
345
8240/3-C34.9
ICD-O-3
Neuroendocrine tumor, NOS, of lung, NOS
+∞
12.6
12
*
TPH07
NOMESCO Finland
Cathetrisation of artery
2.6
12.2
76
320
N02AX02
ATC
tramadol; systemic, rectal
2.0
12.1
239
1599
GDC00
NOMESCO Finland
Lobectomy of lung
23.6
11.6
16
7
GDB10
NOMESCO Finland
Wedge resection of lung
+∞
11.5
11
*
1240
FHL
Bronchoscopy
9.2
11.4
23
26
5188X
ICD-9 Finland
Other diseases of lung
61.4
10.7
12
*
R05
ICD-10 Finland
Cough
2.2
10.5
111
588
2391A
ICD-9 Finland
Neoplasm of unspecified nature, Respiratory system
24.0
10.3
14
6
GAB10
NOMESCO Finland
Antero- or postero-lateral thoracotomy
24.0
10.3
14
6
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
3.0
10.1
48
174
GDA10
NOMESCO Finland
Biopsy of lung
41.0
10.0
12
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.1
9.7
43
150
GDC01
NOMESCO Finland
Thoracoscopic lobectomy of lung
8.3
9.4
20
25
WX250
NOMESCO Finland
Intercostal blockade
22.2
9.4
13
6
XG410
NOMESCO Finland
Flow-volume spirometry
3.5
8.9
31
93
R03BB04
ATC
tiotropium bromide; inhalant
2.3
8.6
70
332
D38.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Mediastinum
28.1
8.5
11
*
23130
ICD-8 Finland
Neoplasm of unspecified nature of respiratory organs, Bronchus and lung
+∞
8.4
8
*
1243
FHL
Bronchoscopy and other therapeutic procedure
+∞
8.4
8
*
ZXE00
NOMESCO Finland
One hour or less
1.8
8.2
189
1284
51925
ICD-8 Finland
Other diseases of respiratory system, Infiltratio pulmonis NUD
14.8
8.2
13
9
5826
FHL
Lobectomy or bilobectomy
34.0
8.1
10
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
8.1
133
816
R4110
NOMESCO Finland
Physiotherapy
1.8
8.0
143
900
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
7.6
7.7
17
23
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.9
7.7
36
130
B01AB05
ATC
enoxaparin; parenteral
1.8
7.6
162
1072
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.1
7.4
31
105
D38.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Respiratory organ, unspecified
30.5
7.2
9
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
7.1
177
1220
B01AB04
ATC
dalteparin; parenteral
3.0
6.9
31
109
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
6.5
138
905
D38.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pleura
70.8
6.4
7
*
D14.4
ICD-10 Finland
Benign neoplasm: Respiratory system, unspecified
+∞
6.3
6
*
XG405
NOMESCO Finland
Education on PEF monitoring
6.4
6.2
15
24
N03AX16
ATC
[U] pregabalin
1.8
6.1
118
752
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
6.0
181
1299

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
31
54
6.07
17.33
1.3
1.7
45.34
16.29
ug/l
0.41
31
54
30
57
5.55
15.33
2.4
3.0
—
—
—
0
0
63
212
3.27
15.19
10.7
8.5
—
—
—
0
0
276
1895
2.07
13.53
14.3
14.2
1.25
1.26
inr
0.07
86
554
103
480
2.46
13.40
8.6
6.9
1.63
1.19
mmol/l
0.56
89
390
94
436
2.44
12.28
8.9
7.0
96.42
95.25
%
1.66
94
422
100
503
2.25
10.76
1.4
1.3
—
—
—
0
0
83
401
2.29
9.77
10.0
7.3
124.78
120.82
g/l
1.06
83
393
263
1926
1.81
9.17
5.1
5.6
1.77
1.91
e9/l
0.98
221
1707
237
1689
1.80
8.99
4.8
4.8
35.59
35.44
g/l
0.17
219
1582
300
2296
1.82
8.92
6.3
4.7
6.83
6.80
mmol/l
0.06
288
2161
265
1958
1.79
8.84
5.2
5.8
0.19
0.20
e9/l
0.38
223
1718
217
1514
1.79
8.79
2.4
2.2
—
—
—
0
0
240
1725
1.78
8.78
5.4
5.6
0.63
0.66
%
0.33
226
1610
257
1891
1.77
8.62
5.2
5.5
0.04
0.04
e9/l
0.03
211
1642
256
1884
1.77
8.55
5.2
5.5
0.62
0.59
e9/l
1.03
209
1630
244
1794
1.73
7.99
5.6
5.5
58.93
57.41
%
1.37
232
1687
287
2209
1.74
7.96
7.7
9.2
4.41
4.16
e9/l
1.07
237
1941
247
1826
1.73
7.90
6.0
5.7
25.92
27.19
%
1.07
234
1717
242
1781
1.72
7.85
5.7
5.6
2.81
2.92
%
0.32
229
1667
239
1755
1.72
7.80
6.8
5.9
1.20
1.21
mmol/l
1.70
227
1592
243
1795
1.72
7.74
2.7
2.6
—
—
—
0
0
242
1790
1.71
7.63
6.0
5.9
8.80
8.78
%
0.03
229
1679
240
1776
1.70
7.52
6.1
6.1
—
—
—
0
0
59
278
2.28
7.31
1.6
1.4
—
—
—
0
0
65
326
2.15
6.92
9.6
7.9
—
—
—
0
0
358
2999
1.76
6.71
8.8
7.8
80.42
78.97
u/l
0.31
344
2807
175
1220
1.68
6.65
2.5
2.3
—
—
—
0
0
27
90
3.12
6.61
8.1
6.4
105.44
105.17
mmol/l
0.12
27
83
27
90
3.12
6.61
8.1
6.4
11.00
11.18
mmol/l
0.10
27
83
18
46
4.03
6.49
2.8
3.0
3.95
7.04
nmol/l
0.39
18
46
251
1934
1.62
6.33
8.6
6.8
1.20
1.21
mmol/l
1.88
216
1636
165
1156
1.65
6.04
3.6
4.2
7.40
7.40
ph
0.21
39
212
176
1257
1.63
5.95
2.8
3.4
37.80
33.11
u/l
0.27
171
1199
39
168
2.44
5.92
7.2
5.0
1.00
0.90
%
0.72
39
159
66
353
2.01
5.92
1.5
1.5
—
—
—
0
0
39
169
2.42
5.85
7.3
4.9
1.93
1.59
%
1.18
39
160
21
66
3.28
5.66
1.9
2.8
—
—
—
0
0
220
1675
1.58
5.61
11.2
9.7
0.00
0.00
e9/l
0.67
167
1385
23
79
3.01
5.38
2.4
3.9
2.36
2.52
mmol/l
0.11
16
52
55
287
2.03
5.28
3.9
4.2
0.00
0.14
%
0.74
16
81
22
75
3.03
5.21
2.2
2.4
16.36
16.16
%
0.05
12
42
54
282
2.03
5.17
5.9
4.3
—
—
—
0
0
325
2739
1.58
5.08
4.4
4.0
—
—
—
0
0
63
354
1.90
4.90
1.4
1.4
—
—
—
0
0
258
2080
1.52
4.83
7.0
6.5
10.58
11.38
umol/l
1.03
249
1978
24
90
2.75
4.82
1.6
2.0
134.43
126.85
g/l
0.45
14
66
54
294
1.94
4.61
3.6
4.0
0.59
0.48
%
0.23
17
99
56
309
1.92
4.60
3.8
4.2
0.06
0.14
%
0.57
17
101
27
115
2.43
4.24
3.8
3.1
—
—
—
0
0
73
450
1.73
4.20
4.5
4.3
51.17
31.41
ug/l
0.17
65
379
58
334
1.84
4.18
3.8
4.0
0.58
0.92
%
0.68
19
126
150
1110
1.51
4.06
4.2
4.3
—
—
—
0
0
21
82
2.63
3.94
2.5
3.0
—
—
—
0
0
47
268
1.84
3.51
9.1
6.9
25.36
24.47
mmol/l
1.18
47
256
39
214
1.90
3.29
1.4
1.2
187.01
214.49
u/ml
0.16
34
196
68
442
1.63
3.21
2.6
2.9
6.95
8.31
umol/l
0.54
58
386
17
69
2.52
2.99
2.5
2.7
4.34
4.51
e9/l
0.12
17
69
319
2823
1.39
2.87
4.8
4.1
12.50
12.60
mm/h
0.04
301
2576
108
798
1.46
2.85
1.7
1.7
1.30
1.24
mg/l
0.07
83
633
17
71
2.45
2.83
2.5
3.2
56.71
57.97
%
0.13
17
71
172
1382
1.38
2.82
4.6
3.9
138.07
110.29
e6/l
0.17
127
1006
19
84
2.31
2.81
3.4
2.3
—
—
—
0
0
18
78
2.36
2.78
1.6
1.7
2.62
4.80
iu/l
—
6
24
8
19
4.26
2.69
2.4
4.3
59.88
95.00
nmol/l
—
8
19
135
1053
1.39
2.62
3.8
3.2
—
—
—
0
0
10
30
3.38
2.61
1.6
1.2
—
—
—
0
0
152
1211
1.37
2.59
4.1
3.4
670.28
118.51
e6/l
0.45
120
942
157
1259
1.37
2.57
3.0
2.5
56.26
126.72
u/l
0.58
149
1171
191
1584
1.34
2.50
4.3
3.8
27.20
50.23
ng/l
2.08
143
1164
153
1241
1.34
2.29
3.1
3.1
1122.40
1476.39
ng/l
1.04
134
1062
108
836
1.38
2.17
3.0
2.7
5.77
4.09
e6/l
0.91
98
758
137
1103
1.34
2.14
4.0
3.2
0.52
0.52
e6/l
0.00
103
839
43
279
1.59
2.09
4.3
3.2
5.14
5.18
kpa
0.09
43
268
401
3756
1.41
2.08
21.3
15.1
25.43
24.38
mg/l
0.27
358
3006
97
749
1.37
1.98
4.2
3.9
225.21
318.25
ng/l
0.30
79
606
71
520
1.43
1.96
2.6
2.5
23.29
22.30
%
0.23
61
451
103
806
1.35
1.93
3.1
3.0
561.44
558.17
mosm/kgh2o
0.05
87
689
6
17
3.56
1.84
1.2
1.0
—
—
—
0
0
47
322
1.51
1.82
3.1
3.8
1.22
1.23
mmol/l
0.21
42
278
46
316
1.50
1.77
3.7
3.8
—
—
—
0
0
41
275
1.54
1.76
4.1
3.2
7.45
7.41
ph
—
10
33
16
82
1.98
1.71
4.6
2.5
—
—
—
0
0
82
633
1.36
1.68
3.7
3.1
2.31
1.71
e6/l
0.25
40
356
6
19
3.18
1.66
1.2
2.2
—
—
—
0
0
6
19
3.18
1.66
1.3
1.3
—
—
—
0
0
65
484
1.40
1.66
1.2
1.3
616.00
517.48
titre
0.21
20
111
7
25
2.83
1.65
4.4
4.2
—
—
—
0
0
10
41
2.47
1.65
3.7
2.5
—
—
—
0
0
20
335
0.58
1.61
3.0
3.4
—
—
—
0
0
7
27
2.62
1.52
4.4
4.1
—
—
—
0
0
6
21
2.88
1.51
1.2
1.1
165.83
194.08
mmol/24h
—
6
21
76
592
1.34
1.48
2.6
2.0
—
—
—
0
0
115
959
1.26
1.35
5.9
6.8
—
—
—
0
0
412
3941
1.32
1.33
23.3
17.5
139.39
139.73
mmol/l
1.70
407
3838
18
106
1.73
1.31
2.6
2.1
9.41
12.81
mg/l
1.08
18
98
80
641
1.30
1.29
4.6
3.4
0.80
0.82
mmol/l
1.15
71
599
13
70
1.88
1.25
1.4
1.4
—
—
—
0
0
6
25
2.42
1.24
1.0
1.2
—
—
—
0
0
59
455
1.34
1.24
1.5
1.3
—
—
—
0
0
13
224
0.57
1.20
1.3
1.2
—
—
—
0
0
412
3954
1.30
1.19
23.5
17.6
3.97
3.99
mmol/l
0.79
406
3847
7
30
2.35
1.12
3.6
2.8
—
—
—
0
0
12
66
1.84
1.10
4.4
2.9
0.90
0.85
nmol/l
0.07
12
52
7
32
2.20
1.08
2.0
1.4
—
—
—
0
0
89
741
1.25
1.06
3.0
3.2
2.46
2.45
mmol/l
0.25
80
653
15
90
1.69
1.05
1.4
1.6
—
—
—
0
0
9
50
1.82
0.97
1.0
1.3
—
—
—
0
0
132
1164
1.18
0.89
2.4
2.1
302.40
279.11
u/l
0.07
126
1095
168
1512
1.17
0.89
3.1
2.7
126.73
137.99
ug/l
0.31
161
1393
7
130
0.53
0.89
4.3
11.7
—
—
—
0
0
47
373
1.29
0.85
4.8
3.8
0.75
2.21
mmol/l
1.01
37
304
57
464
1.26
0.85
1.9
1.6
—
—
—
0
0
8
45
1.79
0.84
1.3
1.2
—
—
—
0
0
8
45
1.79
0.84
1.1
1.3
—
—
—
0
0
414
4012
1.23
0.83
12.7
10.8
26.61
26.63
u/l
0.01
404
3871
116
1020
1.18
0.81
3.7
3.4
—
—
—
0
0
14
211
0.65
0.80
2.1
2.4
—
—
—
0
0
59
486
1.24
0.80
2.0
1.4
—
—
—
0
0
413
4005
1.22
0.80
23.6
18.0
78.99
80.47
umol/l
0.37
413
4005
8
48
1.68
0.79
6.9
5.2
381.25
347.29
umol/l
—
8
42
0
28
0.00
0.76
0.0
1.3
—
22550.79
—
0
19
21
288
0.72
0.75
1.3
1.4
—
—
—
0
0
5
24
2.09
0.74
1.2
1.4
0.96
1.02
g/l
—
5
24
5
24
2.09
0.74
1.0
1.8
34.80
36.06
%
—
5
24
10
60
1.68
0.72
3.9
3.4
0.65
1.13
%
—
10
53
11
170
0.64
0.72
1.5
1.6
—
—
—
0
0
55
457
1.23
0.70
1.5
1.7
—
—
—
0
0
292
2769
1.14
0.70
4.0
3.8
14.92
14.84
pmol/l
0.22
263
2468
5
27
1.86
0.68
2.4
2.7
13.40
13.34
%
—
5
27
5
91
0.54
0.67
1.0
1.3
—
—
—
0
0
14
94
1.50
0.67
4.6
4.1
48.67
27.51
mg/l
—
9
59
44
360
1.24
0.65
2.2
2.4
43.42
32.42
u/l
0.49
38
302
32
253
1.28
0.63
3.7
2.9
—
—
—
0
0
142
1294
1.14
0.62
3.8
3.6
2.36
2.35
mmol/l
0.51
129
1138
8
49
1.64
0.62
1.6
1.7
—
—
—
0
0
8
50
1.61
0.61
1.3
1.2
—
—
—
0
0
18
132
1.38
0.58
1.5
3.6
49.05
111.94
mg/l
0.66
13
105
18
132
1.38
0.58
1.4
3.7
37.18
33.26
mg/l
0.15
13
108
8
54
1.49
0.57
1.0
1.3
0.56
0.53
nmol/l
—
8
49
6
37
1.63
0.55
1.0
1.4
—
—
—
0
0
400
3899
1.16
0.54
19.0
14.4
—
—
—
0
0
41
341
1.22
0.54
2.2
2.5
77.16
69.14
e9/l
0.49
27
278
31
380
0.80
0.53
7.3
4.3
—
—
—
0
0
70
614
1.16
0.53
1.3
1.3
74.55
38.32
iu/ml
0.40
20
200
83
739
1.15
0.52
1.9
1.7
1119.58
1171.59
nmol/l
0.25
63
564
74
833
0.87
0.50
4.1
4.1
1.02
1.02
kg/l
—
10
125
7
45
1.56
0.49
4.1
3.6
—
—
—
0
0
7
45
1.56
0.49
1.3
1.1
—
—
—
0
0
197
1856
1.10
0.48
5.2
5.0
0.00
0.00
estimate
-0.00
50
349
10
68
1.48
0.47
1.4
3.1
—
—
—
0
0
8
121
0.66
0.46
1.3
1.1
—
—
—
0
0
15
112
1.35
0.45
1.3
1.5
316.88
295.75
ug/g
—
8
68
102
933
1.12
0.43
2.3
2.1
2.98
3.13
mg/l
0.21
89
804
12
162
0.73
0.43
6.6
4.4
—
—
—
0
0
129
1197
1.11
0.42
5.5
4.0
—
—
—
0
0
111
1022
1.11
0.42
4.3
4.0
0.00
0.00
estimate
-0.00
47
339
0
16
0.00
0.41
0.0
1.2
—
7.45
—
0
16
15
194
0.77
0.41
1.5
1.4
—
—
—
0
0
22
177
1.25
0.41
3.4
2.9
—
—
—
0
0
375
3834
0.90
0.40
5.2
5.2
2.68
2.70
mmol/l
0.17
345
3509
68
755
0.88
0.39
1.4
1.2
0.63
1.55
u/ml
1.82
23
208
5
35
1.43
0.39
1.0
1.1
—
—
—
0
0
8
112
0.71
0.37
1.5
2.9
1.43
1.58
mg/l
—
8
102
127
1186
1.10
0.37
3.5
3.2
30.36
217.11
mg/l
1.32
85
783
111
1030
1.10
0.37
1.6
1.7
1.51
1.41
mmol/l
0.54
84
853
131
1226
1.09
0.36
3.3
3.1
7.67
7.67
mmol/l
0.01
108
1019
5
80
0.62
0.35
1.2
1.2
2.40
12.19
e6/l
—
5
64
5
80
0.62
0.35
1.2
1.3
7.60
1528.26
e6/l
—
5
66
10
73
1.38
0.34
1.7
2.0
4.91
4.82
mmol/24h
—
10
64
6
44
1.37
0.34
1.2
1.1
—
—
—
0
0
379
3713
1.10
0.34
5.0
4.8
6.03
6.04
mmol/l
0.06
345
3366
6
45
1.34
0.34
1.2
1.3
—
—
—
0
0
6
45
1.34
0.34
1.2
1.1
—
—
—
0
0
349
3411
1.08
0.32
4.9
4.5
1.84
1.96
mu/l
1.05
319
3059
193
1848
1.07
0.31
3.9
3.7
0.04
0.00
estimate
0.45
54
379
196
1878
1.07
0.31
4.0
3.7
0.00
0.01
estimate
0.50
44
336
7
54
1.30
0.30
1.3
2.1
—
—
—
0
0
7
56
1.25
0.29
1.0
1.0
—
—
—
0
0
8
110
0.72
0.29
1.3
1.2
—
—
—
0
0
104
975
1.09
0.28
2.6
3.1
0.61
0.78
ug/l
2.14
71
645
253
2452
1.07
0.28
3.7
3.2
56.21
54.24
u/l
0.09
241
2279
16
131
1.23
0.27
2.6
3.2
0.24
0.20
g/l
—
10
50
269
2615
1.07
0.26
4.7
4.2
—
—
—
0
0
123
1165
1.08
0.26
4.1
3.0
—
—
—
0
0
6
85
0.70
0.24
1.7
1.3
—
—
—
0
0
10
125
0.80
0.23
7.5
4.1
—
—
—
0
0
5
39
1.28
0.23
1.2
1.3
—
—
—
0
0
172
1657
1.06
0.22
4.5
5.0
2.09
3.22
ug/l
1.50
155
1477
82
871
0.93
0.22
3.8
3.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
2.41
—
0
11
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
6.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
8
104
0.77
0.21
1.0
1.1
—
—
—
0
0
76
808
0.93
0.21
2.2
1.8
403.23
5943965.31
pmol/l
0.50
64
673
11
89
1.24
0.21
1.1
1.2
—
—
—
0
0
108
1028
1.07
0.21
2.8
2.7
8399.24
7246.80
umol/l
0.07
98
899
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
162
1563
1.06
0.20
1.9
2.0
97.99
92.82
pmol/l
0.66
88
827
419
4147
1.08
0.20
30.1
22.2
39.85
40.24
%
0.55
395
3880
6
49
1.23
0.20
1.0
1.3
—
—
nmol/l
—
0
0
103
981
1.06
0.19
1.4
1.3
—
—
—
0
0
419
4148
1.08
0.19
29.3
22.1
7.17
6.72
e9/l
2.49
409
4026
419
4148
1.08
0.19
29.3
22.1
250.86
244.18
e9/l
1.26
411
4038
23
203
1.14
0.19
4.7
3.4
—
—
—
0
0
370
3749
0.94
0.19
4.6
4.6
4.53
4.59
mmol/l
0.51
343
3454
419
4149
1.08
0.19
29.3
22.1
4.51
4.49
e12/l
0.42
411
4030
44
406
1.09
0.18
2.3
2.3
112.27
134.15
ug/g
0.37
33
329
12
100
1.21
0.18
1.2
4.0
—
—
—
0
0
7
59
1.19
0.18
1.0
1.3
—
—
—
0
0
143
1481
0.95
0.18
3.6
3.5
5.75
5.85
ph
—
8
110
7
61
1.15
0.17
2.3
2.8
—
—
—
0
0
19
167
1.14
0.17
3.1
3.8
25.30
25.17
mmol/l
0.07
19
155
368
3725
0.95
0.17
4.6
4.6
1.41
1.44
mmol/l
0.61
338
3414
8
68
1.18
0.16
1.1
1.3
—
—
—
0
0
15
130
1.16
0.16
1.7
1.7
—
—
—
0
0
8
73
1.10
0.15
1.1
1.3
—
—
—
0
0
6
76
0.79
0.15
1.0
1.2
—
—
—
0
0
41
381
1.08
0.15
1.3
1.6
—
—
—
0
0
23
254
0.90
0.14
1.0
1.2
—
—
—
0
0
256
2514
1.04
0.14
5.4
4.4
20.75
3093.02
e6/l
—
8
44
23
208
1.11
0.14
1.2
1.2
37.16
145.28
iu/ml
—
7
80
152
1478
1.04
0.14
2.6
2.3
77.22
77.09
nmol/l
0.02
135
1317
129
1252
1.04
0.13
3.9
3.8
6.45
8.19
mg/mmol
0.29
88
802
11
127
0.86
0.12
2.8
1.8
29.09
21.29
s
0.64
11
116
136
1323
1.04
0.12
2.9
3.0
—
—
—
0
0
11
95
1.16
0.11
1.9
2.4
—
—
—
0
0
31
289
1.08
0.11
1.3
2.3
—
—
—
0
0
17
187
0.91
0.10
1.7
1.3
—
—
—
0
0
358
3607
0.97
0.08
4.1
4.1
1.31
1.31
mmol/l
0.04
322
3286
12
133
0.90
0.07
1.4
1.5
—
—
—
0
0
12
133
0.90
0.07
1.5
2.0
37.34
37.77
g/l
0.10
12
119
8
74
1.08
0.07
1.1
1.3
—
—
—
0
0
8
74
1.08
0.07
1.1
1.3
—
—
—
0
0
359
3565
1.03
0.07
6.1
6.1
40.84
40.48
mmol/mol
0.27
330
3304
8
75
1.07
0.07
1.1
1.3
—
—
—
0
0
37
353
1.05
0.07
1.2
1.6
—
—
—
0
0
9
87
1.04
0.07
1.4
1.7
244.78
230.66
pmol/l
—
9
80
8
92
0.87
0.07
1.3
1.4
1.15
0.86
nmol/l
—
8
78
27
256
1.06
0.06
4.6
3.1
128.15
128.05
g/l
0.01
27
251
22
208
1.06
0.05
1.2
1.5
—
—
—
0
0
38
394
0.96
0.05
1.4
1.5
—
—
—
0
0
35
362
0.96
0.04
2.4
2.7
6.39
8.38
ug/l
0.57
30
320
52
510
1.02
0.02
1.3
1.2
—
—
—
0
0
16
152
1.05
0.02
1.4
1.8
—
—
—
0
0
17
162
1.05
0.02
1.3
1.3
—
—
—
0
0
11
103
1.07
0.02
1.1
1.1
—
—
—
0
0
59
596
0.99
0.00
1.3
1.3
20.08
15.17
u/ml
0.22
18
232
14
144
0.97
0.00
1.0
1.1
—
—
—
0
0
22
224
0.98
0.00
1.2
1.3
—
—
—
0
0
21
212
0.99
0.00
4.3
3.5
—
—
—
0
0
10
99
1.01
0.00
1.4
1.7
—
—
—
0
0
15
149
1.01
0.00
1.4
2.0
8.57
10.51
g/l
1.73
15
134
15
149
1.01
0.00
2.2
2.0
1401.37
589.66
ug/l
0.29
15
141
69
688
1.00
0.00
1.4
1.3
2.39
2.63
g/l
0.62
50
407
92
924
0.99
0.00
1.6
1.6
18.65
20.50
nmol/l
0.72
82
778
0
5
0.00
0.00
0.0
1.0
—
7.59
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
-0.00
1.0
1.1
—
23.40
—
0
10
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
67
0.89
-0.00
1.0
1.5
—
—
—
0
0
6
63
0.95
-0.00
1.2
1.1
—
—
—
0
0
6
64
0.94
-0.00
1.2
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
17.76
—
0
7
0
6
0.00
-0.00
0.0
1.5
—
40.00
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_BRONCHUS_LUNG and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_BRONCHUS_LUNG 1.748 [1.41, 2.17] < 0.001
Birth year 0.993 [0.98, 1.0] 0.142

During the follow-up period (1.1.1998 — 31.12.2019), 137 out of 715 females with CD2_BENIGN_BRONCHUS_LUNG died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_BRONCHUS_LUNG 1.92 [1.6, 2.3] < 0.001
Birth year 0.992 [0.98, 1.0] 0.072

During the follow-up period (1.1.1998 — 31.12.2019), 241 out of 829 males with CD2_BENIGN_BRONCHUS_LUNG died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_BRONCHUS_LUNG.

N-year risk Females Males
1 0.114% 0.359%
5 0.91% 2.593%
10 2.427% 6.229%
15 4.365% 11.649%
20 8.005% 19.781%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_BRONCHUS_LUNG – Benign neoplasm: Bronchus and lung

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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