brain disease: A disease affecting the brain or part of the brain.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
339 |
4. Check minimum number of eventsNone |
339 |
5. Include endpointsNone |
339 |
6. Filter based on genotype QC (FinnGen only) |
339 |
Control definitions (FinnGen only)
- Control exclude
- G6_OTHNEU
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G93
- Name in latin
- Encephalopathia non specificata
Similar endpoints
↥List of similar endpoints to
Encephalopathy
based on the number of shared cases.
Similar with more cases:
- Other neurological diseases
- Condition for Implicit Sepsis (Organ dysfunction codes)
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4284 | 1649 | 2575 |
| Only index persons | 2826 | 1169 | 1657 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.05 | 0.07 |
| Only index persons | 0.05 | 0.04 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 60.73 | 60.46 | 60.73 |
| Only index persons | 58.69 | 58.57 | 58.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 339 | 126 | 213 |
| Unadjusted period prevalence (%) | 0.07 | 0.04 | 0.09 |
| Median age at first event (years) | 59.71 | 56.29 | 61.74 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 308
- Matched controls
- 3078
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G93.4
ICD-10 Finland
Encephalopathy, unspecified
+∞
323.0
280
*
3483X
ICD-9 Finland
Other conditions of brain, Encephalopathy, unspecified
+∞
30.7
29
*
A07AA11
ATC
rifaximin; oral
320.6
29.3
29
*
AA1AD
NOMESCO Finland
CT of head and brain
4.5
28.0
122
390
A06AD11
ATC
lactulose; oral
5.1
27.8
102
272
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
20.7
26.9
40
22
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
21.1
26.4
39
21
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
7.9
22.7
54
81
R41.0
ICD-10 Finland
Disorientation, unspecified
13.0
22.5
40
35
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.5
21.5
136
571
R18
ICD-10 Finland
Ascites
17.4
21.1
33
21
K70.4
ICD-10 Finland
Alcoholic hepatic failure
118.0
20.8
22
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.1
19.2
85
262
K72.9
ICD-10 Finland
Hepatic failure, unspecified
106.6
18.8
20
*
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
23.5
18.5
26
12
R56.8
ICD-10 Finland
Other and unspecified convulsions
8.5
18.1
40
53
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.7
18.0
54
110
C03DA01
ATC
spironolactone; oral
4.4
17.6
69
188
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
27.4
17.2
23
9
C03CA01
ATC
furosemide; systemic
2.9
15.6
129
617
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
6.5
15.5
41
71
R53
ICD-10 Finland
Malaise and fatigue
3.3
15.1
89
338
A28
ICPC
Limited function/disability NOS
3.6
15.0
76
258
N03AX14
ATC
levetiracetam; systemic
11.3
14.5
27
26
N05AH04
ATC
quetiapine; oral
3.5
14.5
74
252
C07AA05
ATC
propranolol; systemic
3.5
14.3
76
266
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.6
13.7
68
226
K72.1
ICD-10 Finland
Chronic hepatic failure
42.0
13.3
16
*
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
10.8
13.2
25
25
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.7
13.2
63
202
N03AG01
ATC
valproic acid; systemic, rectal
5.6
13.2
39
78
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
33.6
12.7
16
5
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.9
12.5
42
97
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
10.7
12.2
23
23
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.7
12.1
103
486
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
5.1
12.0
38
82
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
11.2
12.0
22
21
XA800
NOMESCO Finland
Neuropsychological investigation
6.6
11.4
29
48
TAB00
NOMESCO Finland
Lumbar puncture
7.1
11.2
27
41
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
5.0
11.1
36
80
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.3
10.8
41
107
N05AD01
ATC
haloperidol; systemic
7.3
10.6
25
37
F05.9
ICD-10 Finland
Delirium, unspecified
9.3
10.5
21
24
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.8
10.5
45
132
R50.9
ICD-10 Finland
Fever, unspecified
3.1
10.3
59
216
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
9.6
10.2
20
22
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
17.4
10.0
15
9
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
4.2
10.0
38
100
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.4
9.9
36
90
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
4.6
9.9
34
81
N05AX08
ATC
risperidone; systemic
3.7
9.5
42
126
F10.09
ICD-10 Finland
Alcohol intoxication UNS
12.9
9.5
16
13
N05BA01
ATC
diazepam; systemic, rectal
3.1
9.5
54
197
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.2
9.4
36
95
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.3
9.4
48
162
P15
ICPC
Chronic alcohol abuse
8.1
9.3
20
26
G40.9
ICD-10 Finland
Epilepsy, unspecified
6.6
9.3
23
37
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
14.3
9.3
15
11
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.9
9.2
38
108
N03AF02
ATC
oxcarbazepine; oral
6.9
9.1
22
34
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
37.9
9.1
11
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.9
9.1
29
64
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.7
9.1
67
286
N05AH03
ATC
olanzapine; systemic
4.8
8.9
29
65
103
Kela drug reimbursment
Diabetes, insulin-treated
2.3
8.8
102
553
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.5
8.8
41
129
SPAT1255
SPAT
Intravenous administration of medicine
4.2
8.8
33
86
J01MA02
ATC
ciprofloxacin; systemic
2.1
8.7
135
830
TK800
NOMESCO Finland
Hemodialysis
7.3
8.7
20
29
K92.1
ICD-10 Finland
Melaena
4.0
8.6
34
93
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.1
8.6
33
88
G41.9
ICD-10 Finland
Status epilepticus, unspecified
28.4
8.5
11
*
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
28.4
8.5
11
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.3
8.5
89
458
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.6
8.5
68
305
UJD02
NOMESCO Finland
Gastroscopy
4.7
8.5
28
64
B03BA03
ATC
hydroxocobalamin; parenteral
4.4
8.4
30
74
A10AE04
ATC
insulin glargine; parenteral
3.3
8.4
42
139
R1250
NOMESCO Finland
Evaluation of functional capability
9.9
8.4
16
17
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.3
8.3
91
476
N06AX11
ATC
mirtazapine; oral
2.2
8.2
105
592
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.3
8.2
24
48
SPAT1229
SPAT
Assessment of need for aid
3.5
8.1
37
115
R55
ICD-10 Finland
Syncope and collapse
3.0
8.0
46
168
N05CF01
ATC
zopiclone; oral
2.1
8.0
110
639
N03AF01
ATC
carbamazepine; oral, rectal
4.3
8.0
29
73
N03AX12
ATC
gabapentin; oral
2.7
7.9
56
233
D64.9
ICD-10 Finland
Anaemia, unspecified
3.0
7.9
46
170
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.5
7.8
36
112
SPAT1262
SPAT
Handing over of treatment supplies
2.5
7.7
67
310
F10.20
ICD-10 Finland
Alcohol dependence currently independent
8.4
7.7
16
20
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.1
7.6
42
147
K76.7
ICD-10 Finland
Hepatorenal syndrome
25.7
7.6
10
*
L28
ICPC
Limited function/disability (L)
2.5
7.6
64
292
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
7.6
142
928
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
5.3
7.6
22
44
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.8
7.4
30
84
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.1
7.4
41
146
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.5
7.3
61
279
G93.8
ICD-10 Finland
Other specified disorders of brain
+∞
7.3
7
*
G41.2
ICD-10 Finland
Complex partial status epilepticus
+∞
7.3
7
*
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
+∞
7.3
7
*
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
+∞
7.3
7
*
N06AB04
ATC
citalopram; systemic
2.3
7.3
74
374
N03AE01
ATC
clonazepam; systemic
4.3
7.3
26
65
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.6
7.3
57
250
N02AA05
ATC
oxycodone; systemic
2.5
7.2
58
260
K92.0
ICD-10 Finland
Haematemesis
6.9
7.2
17
26
W19
ICD-10 Finland
Unspecified fall
3.1
7.2
40
142
N05BA09
ATC
clobazam; oral
20.6
7.2
10
5
K90
ICPC
Stroke/cerebrovascular accident
7.3
7.1
16
23
N05BE01
ATC
buspirone; oral
6.6
7.0
17
27
A41.9
ICD-10 Finland
Sepsis, unspecified
4.6
7.0
23
53
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.4
7.0
59
272
N03AX16
ATC
pregabalin; oral
2.2
6.9
75
391
N05BA04
ATC
oxazepam; oral
2.2
6.8
82
444
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
23.1
6.7
9
*
R11
ICD-10 Finland
Nausea and vomiting
3.3
6.5
31
100
SPAT1254
SPAT
Administration of medicine
2.5
6.5
53
240
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
71.2
6.4
7
*
WX730
NOMESCO Finland
Conventional respirator
8.4
6.4
13
16
N05AN01
ATC
lithium; oral
8.4
6.4
13
16
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
4.5
6.4
21
49
N05CD07
ATC
temazepam; oral
2.5
6.4
52
234
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
11.3
6.3
11
10
T90.5
ICD-10 Finland
Sequelae of intracranial injury
11.3
6.3
11
10
D97
ICPC
Liver disease NOS
18.5
6.3
9
5
G93.99
ICD-10 Finland
Disorder of brain, unspecified
+∞
6.3
6
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.5
6.3
49
216
N06AG02
ATC
moclobemide; oral
4.4
6.3
21
50
N03AX09
ATC
lamotrigine; oral
4.9
6.2
19
41
Z02.7
ICD-10 Finland
Issue of medical certificate
3.7
6.2
25
71
N06AX16
ATC
venlafaxine; oral
2.7
6.1
42
170
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
12.9
6.1
10
8
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
5.0
6.0
18
38
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
96
56
23.52
121.70
12.3
2.6
54.5
32.1
umol/l
6.21
84
49
93
222
5.39
38.38
15.7
7.6
11.9
10.3
mmol/l
1.20
88
210
44
47
10.61
37.94
1.3
1.4
3.5
10.6
e6/l
0.56
38
36
30
20
16.36
34.36
1.3
1.2
—
—
—
0
0
113
348
4.37
33.60
10.6
5.7
1.1
1.0
mmol/l
0.86
107
320
90
254
4.46
29.69
5.3
2.2
0.2
0.2
g/l
7.88
85
236
20
11
19.26
24.91
1.2
1.1
1.9
1.7
mmol/l
0.69
20
11
19
10
20.07
24.09
4.7
2.8
67.5
107.4
%
—
19
10
20
12
17.65
23.91
1.2
1.1
—
—
—
0
0
78
239
3.94
22.57
6.0
4.4
1.5
2.0
mmol/l
0.39
65
185
18
10
18.95
22.24
1.3
1.2
—
—
—
0
0
23
21
11.68
21.77
1.3
1.1
—
—
—
0
0
109
427
3.29
21.54
6.1
3.0
0.8
0.8
mmol/l
2.39
102
400
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
19
15
13.36
19.59
1.2
1.1
—
—
—
0
0
29
44
7.11
18.61
1.2
1.1
349.8
336.2
u/ml
0.05
22
23
158
845
2.63
16.79
5.3
2.4
66.0
56.7
u/l
0.58
149
774
28
46
6.54
16.66
1.2
1.2
—
—
—
0
0
113
515
2.79
16.48
1.8
1.7
1250.6
1140.6
nmol/l
0.46
91
375
79
308
3.04
15.23
3.3
4.1
230.8
259.2
u/l
1.13
71
291
204
1294
2.45
14.28
14.4
6.8
1.2
1.2
mmol/l
1.29
185
1079
187
1148
2.40
14.00
14.7
4.9
31.9
35.4
g/l
10.82
178
1071
79
322
2.90
13.97
9.7
3.1
18.5
8.4
umol/l
0.84
70
285
20
28
7.53
13.69
1.1
1.0
—
—
—
0
0
32
72
4.80
13.62
1.5
1.3
—
—
—
0
0
75
302
2.90
13.53
11.1
7.6
1.0
1.2
mmol/l
0.09
61
240
72
286
2.93
13.30
2.6
1.7
1.8
1.5
%
1.74
63
244
55
188
3.30
13.13
2.5
1.6
—
—
—
0
0
28
58
5.17
13.09
8.0
8.1
2009.0
167.3
iu/ml
—
5
9
17
22
8.08
12.39
1.1
1.0
—
—
—
0
0
95
450
2.54
12.38
2.5
1.9
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
32
78
4.43
12.34
5.0
2.3
0.2
0.3
u/ml
2.25
19
40
19
29
6.88
12.04
1.1
1.0
—
—
—
0
0
85
397
2.52
11.31
4.2
2.3
2.2
2.3
g/l
1.29
80
366
28
68
4.40
10.84
1.4
1.4
320.0
287.2
ug/g
0.34
16
34
80
372
2.51
10.69
4.3
2.4
22.1
22.0
%
0.02
65
321
16
23
7.25
10.66
1.2
1.2
—
—
—
0
0
14
18
8.07
10.21
1.1
1.0
—
—
—
0
0
11
10
11.34
10.21
1.1
1.1
—
—
—
0
0
120
677
2.20
10.20
3.1
2.0
3.6
3.2
mg/l
0.78
113
576
50
192
2.88
9.69
8.1
3.9
2.3
1.9
mmol/l
0.26
37
139
11
11
10.30
9.59
1.3
1.0
—
—
—
0
0
11
11
10.30
9.59
1.2
1.3
—
—
—
0
0
179
1200
2.04
9.44
14.0
6.0
1.2
1.2
mmol/l
1.74
170
1076
25
65
4.07
8.86
3.6
1.5
—
—
—
0
0
215
1562
2.03
8.81
12.2
4.6
7.4
6.8
mmol/l
2.07
206
1467
65
307
2.38
8.26
2.4
1.9
—
—
—
0
0
65
313
2.33
7.89
2.4
1.9
—
—
—
0
0
156
1051
1.90
7.60
4.6
2.6
150.9
151.7
ug/l
0.02
148
957
19
45
4.41
7.57
2.0
3.1
—
867.4
u/ml
—
0
5
95
541
2.05
7.56
1.9
1.8
481.7
12809415.8
pmol/l
0.50
81
445
28
91
3.26
7.19
3.2
2.8
—
—
—
0
0
224
1715
1.90
7.14
7.1
4.2
89.8
1235.1
e6/l
—
8
27
72
377
2.16
7.10
16.0
26.0
1.3
1.3
inr
0.05
15
52
51
237
2.36
6.67
1.9
1.8
501.6
384.9
nmol/l
0.41
51
213
12
21
5.89
6.63
1.9
1.4
0.6
1.7
promille
1.74
12
15
200
1503
1.81
6.49
13.7
9.4
4.0
4.2
e9/l
0.41
188
1308
25
81
3.25
6.46
5.9
2.8
24.3
25.0
mmol/l
0.23
20
70
102
625
1.90
6.45
1.8
1.6
19.8
20.1
nmol/l
0.07
92
520
10
7
14.67
6.43
1.3
1.0
—
—
—
0
0
146
1008
1.79
6.25
3.2
2.2
69.6
75.5
nmol/l
1.37
135
888
19
53
3.74
6.13
1.8
1.5
—
—
—
0
0
10
8
12.83
6.12
1.2
1.1
—
—
—
0
0
10
8
12.83
6.12
1.3
1.1
—
—
—
0
0
142
982
1.77
5.98
4.7
3.1
—
—
—
0
0
37
156
2.54
5.96
1.6
1.5
—
—
—
0
0
15
36
4.31
5.88
1.5
1.2
—
—
—
0
0
102
642
1.84
5.86
4.2
2.4
—
—
—
0
0
41
185
2.38
5.72
5.0
3.8
117.7
92.2
ng/l
0.51
36
159
9
7
13.16
5.61
1.3
1.1
—
—
—
0
0
9
7
13.16
5.61
1.2
1.1
—
—
—
0
0
23
79
3.05
5.41
1.5
1.3
—
—
—
0
0
9
8
11.51
5.32
1.2
1.1
—
—
—
0
0
226
2637
0.57
5.28
5.6
5.0
2.4
2.7
mmol/l
5.36
211
2394
217
2559
0.58
5.28
5.0
4.5
1.3
1.4
mmol/l
6.23
204
2330
13
31
4.32
5.14
1.3
1.9
—
—
—
0
0
163
1209
1.67
5.09
7.1
4.3
—
—
—
0
0
220
2578
0.58
5.08
5.1
4.5
4.2
4.6
mmol/l
7.76
207
2372
148
1071
1.68
5.08
2.6
2.0
91.1
92.9
pmol/l
0.17
84
557
10
19
5.39
5.07
2.4
1.4
0.9
1.0
g/l
—
10
19
89
559
1.80
5.06
2.0
1.7
2.3
1.4
mg/l
0.76
73
437
10
20
5.12
4.80
1.0
1.0
—
—
—
0
0
81
502
1.81
4.79
4.6
3.6
321.9
369.6
ng/l
0.06
67
403
30
128
2.47
4.73
10.0
4.4
24.5
24.7
mmol/l
0.09
30
118
17
54
3.26
4.55
1.9
1.3
—
—
—
0
0
17
54
3.26
4.55
1.9
1.3
—
—
—
0
0
16
50
3.31
4.39
1.8
1.6
—
—
—
0
0
34
160
2.25
4.33
15.5
9.4
93.6
94.1
%
0.17
34
160
17
56
3.14
4.30
1.1
1.1
—
—
—
0
0
7
6
11.87
4.29
1.3
1.0
1109.3
1425.0
miu/ml
—
7
6
7
6
11.87
4.29
1.0
1.2
—
—
—
0
0
25
103
2.54
4.24
2.5
1.7
—
—
—
0
0
27
116
2.44
4.21
1.6
2.1
39.6
38.8
u/l
0.06
22
103
79
504
1.74
4.20
1.4
1.3
1.1
1.6
u/ml
0.43
16
124
42
723
0.52
3.87
2.5
3.0
0.5
0.8
ug/l
7.06
28
494
24
102
2.46
3.84
1.8
2.5
—
—
—
0
0
24
102
2.46
3.84
1.8
2.5
6.9
7.3
g/l
0.49
15
78
24
102
2.46
3.84
1.8
2.5
3.8
3.8
g/l
0.03
15
74
25
110
2.37
3.72
3.0
1.8
—
—
—
0
0
17
62
2.83
3.64
1.9
1.7
—
—
—
0
0
22
95
2.41
3.41
1.7
2.6
2.8
3.1
g/l
0.61
15
76
217
2480
0.65
3.37
4.5
4.0
1.4
1.3
mmol/l
0.49
201
2243
240
2064
1.56
3.37
19.8
7.5
97.8
80.3
u/l
4.49
231
1923
18
71
2.62
3.35
1.7
2.5
—
—
—
0
0
9
19
4.84
3.26
2.9
2.1
—
—
—
0
0
8
15
5.43
3.21
1.5
1.5
—
—
—
0
0
17
67
2.62
3.18
1.8
1.4
—
—
—
0
0
104
761
1.53
3.10
4.0
3.1
0.8
0.5
e6/l
0.61
83
574
135
1047
1.48
3.03
6.3
3.8
30.7
50.0
ng/l
1.82
114
767
14
51
2.82
3.02
1.3
1.4
—
—
—
0
0
204
1716
1.47
3.01
10.4
3.2
96.5
50.6
u/l
4.11
195
1591
16
63
2.62
3.00
1.9
1.7
—
—
—
0
0
5
5
10.12
2.99
1.0
1.2
—
—
—
0
0
115
868
1.49
2.94
4.9
3.9
18.3
10.1
mg/mmol
0.76
94
569
9
22
4.17
2.90
1.2
1.6
20.9
13.9
u/l
—
9
22
112
843
1.49
2.89
3.0
3.1
1727.6
1487.3
ng/l
0.27
98
714
7
13
5.47
2.88
1.1
1.5
—
—
—
0
0
18
77
2.41
2.87
1.5
1.6
—
—
—
0
0
20
90
2.30
2.86
2.2
2.9
1.2
0.7
g/l
0.30
15
79
8
18
4.52
2.81
1.0
1.4
—
—
—
0
0
9
23
3.99
2.79
1.2
1.2
—
—
—
0
0
6
10
6.08
2.71
2.3
2.1
—
—
—
0
0
15
61
2.53
2.66
1.5
1.5
—
—
—
0
0
11
38
2.96
2.60
1.3
1.7
—
—
—
0
0
11
39
2.88
2.50
1.5
1.1
—
—
—
0
0
48
308
1.65
2.48
3.0
4.4
22.7
47.2
ug/l
0.38
40
258
12
45
2.73
2.47
1.3
1.6
—
—
—
0
0
112
866
1.44
2.46
5.6
3.4
2.3
2.3
mmol/l
1.08
97
756
30
168
1.86
2.46
1.8
1.7
—
—
—
0
0
6
12
5.07
2.41
1.2
1.0
—
—
—
0
0
34
202
1.76
2.32
4.4
2.6
58.7
64.7
ml/min/173m2
0.33
16
88
6
13
4.68
2.28
1.2
1.0
—
—
—
0
0
94
713
1.44
2.27
4.6
2.7
16226.0
10141.2
umol/l
0.28
85
603
8
198
0.39
2.25
1.3
1.8
—
—
—
0
0
75
996
0.68
2.23
3.5
4.4
17.5
21.6
%
1.74
33
495
10
36
2.83
2.22
1.0
1.0
—
—
—
0
0
7
20
3.55
2.06
2.9
2.0
0.2
0.1
e9/l
—
7
15
44
290
1.59
2.06
5.5
3.3
—
—
—
0
0
13
57
2.33
2.00
1.0
1.1
60.2
22.0
u/l
0.48
13
48
7
21
3.38
1.97
2.9
2.0
584.0
486.6
e6/l
—
7
15
65
472
1.47
1.96
3.3
2.7
2.6
0.9
e6/l
0.97
44
279
211
1861
1.35
1.95
4.5
3.5
14.6
14.9
pmol/l
0.66
194
1653
6
16
3.80
1.94
1.3
2.3
—
—
—
0
0
10
39
2.61
1.94
2.1
1.7
—
—
—
0
0
218
1936
1.35
1.91
6.8
4.0
19.4
12.7
mm/h
5.05
205
1759
215
2377
0.74
1.90
42.4
15.9
35.1
40.0
%
6.03
121
1646
7
22
3.23
1.89
1.6
1.1
—
—
—
0
0
11
47
2.39
1.79
2.2
1.9
—
—
—
0
0
225
2462
0.74
1.77
35.2
13.8
73.2
78.9
ml/min/173m2
2.35
191
2030
10
42
2.42
1.69
2.0
1.6
—
—
—
0
0
8
31
2.62
1.67
2.3
1.8
—
—
—
0
0
276
2918
0.71
1.61
54.3
21.6
126.3
136.2
g/l
14.33
270
2865
7
26
2.73
1.59
2.7
1.7
—
—
—
0
0
103
1242
0.75
1.59
3.3
5.0
1.5
3.2
ug/l
2.12
91
1102
276
2916
0.71
1.58
53.8
21.5
4.2
4.5
e12/l
14.53
269
2816
16
85
1.93
1.57
1.7
1.4
0.0
0.1
iu/ml
—
5
20
13
64
2.07
1.56
4.6
2.4
131.9
129.3
g/l
0.10
13
49
59
445
1.39
1.46
4.3
2.9
4.3
1.8
e6/l
0.64
39
254
7
28
2.53
1.46
1.4
2.0
—
—
—
0
0
5
16
3.16
1.44
1.8
1.8
—
—
—
0
0
5
16
3.16
1.44
1.8
1.8
—
—
—
0
0
238
2558
0.77
1.41
5.7
4.7
6.6
6.0
mmol/l
4.92
222
2311
84
675
1.32
1.40
6.5
4.0
0.0
0.0
estimate
0.50
20
213
12
60
2.04
1.40
7.3
2.7
16.8
16.3
%
—
7
35
6
23
2.64
1.37
1.2
1.6
—
—
—
0
0
6
24
2.53
1.31
1.5
1.3
—
—
—
0
0
6
24
2.53
1.31
1.5
1.3
—
—
—
0
0
8
37
2.19
1.22
2.6
1.8
—
—
—
0
0
56
712
0.74
1.22
2.0
1.7
1.6
1.4
mmol/l
0.73
48
590
64
505
1.33
1.21
3.9
3.0
2.5
2.5
mmol/l
1.58
52
443
13
72
1.84
1.16
1.4
1.3
—
—
—
0
0
141
1238
1.24
1.13
5.4
3.7
0.0
0.0
estimate
0.00
23
225
7
34
2.08
1.03
2.0
1.7
—
—
—
0
0
232
2468
0.81
1.01
8.7
6.0
42.2
40.3
mmol/mol
1.48
220
2288
7
35
2.02
1.00
2.1
1.7
—
—
—
0
0
7
35
2.02
1.00
2.0
1.7
—
—
—
0
0
7
35
2.02
1.00
2.1
1.7
—
—
—
0
0
7
36
1.96
0.97
2.0
1.7
—
—
—
0
0
7
36
1.96
0.97
2.0
1.7
—
—
—
0
0
9
52
1.75
0.93
1.4
1.4
—
—
—
0
0
138
1233
1.20
0.89
6.6
5.1
0.0
0.0
estimate
0.00
23
227
19
128
1.51
0.88
1.2
1.2
39.1
135.5
iu/ml
—
10
48
6
30
2.02
0.87
3.5
5.3
—
—
—
0
0
6
30
2.02
0.87
1.2
1.1
—
—
—
0
0
139
1253
1.19
0.80
5.3
3.7
0.0
0.0
estimate
0.00
21
210
12
75
1.62
0.76
1.7
1.5
—
—
—
0
0
109
967
1.19
0.75
6.2
3.9
—
—
—
0
0
5
24
2.10
0.75
1.4
1.2
—
—
—
0
0
5
24
2.10
0.75
5.6
2.0
—
—
—
0
0
5
25
2.01
0.73
1.0
1.3
11.8
11.0
u/l
—
5
25
11
70
1.59
0.66
1.6
1.6
—
—
—
0
0
270
2795
0.83
0.65
23.5
10.5
28.7
26.5
u/l
0.98
263
2692
5
29
1.73
0.64
1.0
1.4
465.8
281.9
u/l
—
5
29
5
30
1.68
0.61
1.0
1.1
—
—
—
0
0
6
35
1.73
0.58
1.2
1.1
—
—
—
0
0
8
54
1.49
0.57
1.1
1.5
—
—
—
0
0
270
2622
1.15
0.43
40.5
14.6
22.1
25.7
mg/l
1.65
246
2080
0
15
0.00
0.41
0.0
4.3
—
255.0
—
0
15
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.6
—
—
—
0
0
43
380
1.15
0.33
1.3
1.3
33.1
14.0
u/ml
0.36
17
134
45
400
1.14
0.32
1.2
1.3
72.5
40.2
iu/ml
0.46
13
130
7
54
1.30
0.30
1.1
1.4
—
283.0
miu/ml
—
0
20
38
343
1.12
0.23
8.7
7.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
287.3
—
0
6
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
9
115
0.78
0.20
1.1
1.3
—
—
—
0
0
39
359
1.10
0.17
4.7
4.5
29.6
31.1
%
0.41
32
231
7
63
1.11
0.17
2.7
1.4
15.8
21.8
iu/l
—
7
51
25
275
0.90
0.15
1.4
1.4
—
—
—
0
0
14
160
0.87
0.14
1.6
1.8
—
—
—
0
0
237
2334
1.05
0.13
5.4
4.2
2.0
2.0
mu/l
0.03
219
2081
5
47
1.06
0.09
1.2
1.6
—
—
—
0
0
5
63
0.79
0.08
2.0
2.0
159.4
234.0
pmol/l
—
5
56
35
363
0.96
0.05
1.3
1.5
—
—
—
0
0
148
1468
1.01
0.02
3.1
2.7
—
—
—
0
0
14
143
0.98
0.00
1.7
1.8
—
—
—
0
0
13
125
1.04
0.00
1.0
1.0
—
—
—
0
0
6
59
1.02
0.00
1.2
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
0.00
0.0
1.0
—
110.8
—
0
6
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
8
0.00
0.00
0.0
4.4
—
119.6
—
0
8
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
7
72
0.97
0.00
1.1
1.1
—
—
—
0
0
7
72
0.97
0.00
1.1
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_ENCEPATH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ENCEPATH | 5.197 [4.2, 6.43] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.725 |
During the follow-up period (1.1.1998 — 31.12.2019), 510 out of 1064 females with G6_ENCEPATH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ENCEPATH | 4.951 [4.13, 5.93] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 805 out of 1493 males with G6_ENCEPATH died.
Mortality risk
Mortality risk for people of age
years, who have G6_ENCEPATH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.537% | 0.72% |
| 5 | 3.665% | 5.005% |
| 10 | 8.454% | 11.984% |
| 15 | 15.556% | 22.374% |
| 20 | 26.651% | 35.56% |
Relationships between endpoints
↥Index endpoint: G6_ENCEPATH – Encephalopathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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