brain disease: A disease affecting the brain or part of the brain.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
370 |
4. Check minimum number of eventsNone |
370 |
5. Include endpointsNone |
370 |
6. Filter based on genotype QC (FinnGen only) |
358 |
Control definitions (FinnGen only)
- Control exclude
- G6_OTHNEU
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G93
- Name in latin
- Encephalopathia non specificata
Similar endpoints
↥List of similar endpoints to
Encephalopathy
based on the number of shared cases.
Similar with more cases:
- Other neurological diseases
- Condition for Implicit Sepsis (Organ dysfunction codes)
- Condition for Implicit Sepsis (Organ dysfunction codes)
- Neurological diseases
- Neurological diseases, wide definition
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4284 | 1649 | 2575 |
| Only index persons | 2826 | 1169 | 1657 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.05 | 0.07 |
| Only index persons | 0.05 | 0.04 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 60.73 | 60.46 | 60.73 |
| Only index persons | 58.69 | 58.57 | 58.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 358 | 136 | 222 |
| Unadjusted period prevalence (%) | 0.08 | 0.05 | 0.10 |
| Median age at first event (years) | 60.87 | 59.18 | 61.91 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 370
- Matched controls
- 3700
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G93.4
ICD-10 Finland
Encephalopathy, unspecified
4503599627370496.0
307.7
340
*
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
48.5
91.0
54
13
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
29.3
77.1
53
21
R18
ICD-10 Finland
Ascites
18.9
61.9
51
31
A06AD11
ATC
lactulose; oral
5.3
47.4
128
338
R41.0
ICD-10 Finland
Disorientation, unspecified
13.7
47.1
46
38
A07AA11
ATC
rifaximin; oral
507.2
46.3
45
*
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
16.0
39.6
35
24
AA1AD
NOMESCO Finland
CT of head and brain
4.2
39.2
161
577
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
6.4
35.8
66
121
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.8
34.6
173
698
3483X
ICD-9 Finland
Other conditions of brain, Encephalopathy, unspecified
+∞
32.8
31
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
11.6
31.8
34
32
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
45.5
30.6
37
9
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
5.3
29.1
65
142
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
6.5
28.4
50
87
N03AX14
ATC
levetiracetam; systemic
10.3
28.4
33
35
N03AG01
ATC
valproic acid; systemic, rectal
6.1
27.8
52
96
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
10.2
27.5
32
34
C03DA01
ATC
spironolactone; oral
4.1
27.2
90
268
R56.8
ICD-10 Finland
Other and unspecified convulsions
6.3
26.2
47
83
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.0
25.7
88
268
N17.9
ICD-10 Finland
Acute renal failure, unspecified
6.9
25.0
41
66
TK800
NOMESCO Finland
Hemodialysis
10.1
24.7
29
31
XA800
NOMESCO Finland
Neuropsychological investigation
7.5
24.7
37
54
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.4
24.0
111
412
C03CA01
ATC
furosemide; systemic
2.9
21.6
167
824
K70.4
ICD-10 Finland
Alcoholic hepatic failure
53.4
21.4
25
5
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.8
21.1
76
238
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.3
21.0
60
159
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
32.2
20.9
27
9
K72.1
ICD-10 Finland
Chronic hepatic failure
222.0
20.8
21
*
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.9
19.8
47
107
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.1
19.6
60
167
K72.9
ICD-10 Finland
Hepatic failure, unspecified
36.5
19.1
24
7
G40.9
ICD-10 Finland
Epilepsy, unspecified
6.4
19.0
33
56
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.8
18.9
46
107
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.6
18.5
47
113
N05AH04
ATC
quetiapine; oral
3.2
18.2
90
342
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.8
17.7
59
174
A28
ICPC
Limited function/disability NOS
3.0
17.7
97
391
K92.0
ICD-10 Finland
Haematemesis
7.5
17.6
26
37
C07AA05
ATC
propranolol; systemic
3.0
17.2
96
390
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
16.9
96
393
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
37.0
16.9
21
6
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.2
16.8
49
131
N05AD01
ATC
haloperidol; systemic
6.2
16.0
28
48
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.0
16.0
49
136
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
35.1
15.9
20
6
R53
ICD-10 Finland
Malaise and fatigue
2.7
15.9
113
520
TAB00
NOMESCO Finland
Lumbar puncture
4.8
15.8
37
83
N03AF02
ATC
oxcarbazepine; oral
6.4
15.3
26
43
A41.9
ICD-10 Finland
Sepsis, unspecified
5.4
15.1
31
62
A10AB05
ATC
insulin aspart; parenteral
3.7
15.0
51
152
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.7
14.7
28
52
K76.7
ICD-10 Finland
Hepatorenal syndrome
155.9
14.6
15
*
D64.9
ICD-10 Finland
Anaemia, unspecified
3.2
14.3
62
216
N05AX08
ATC
risperidone; systemic
3.6
14.3
52
162
SPAT1255
SPAT
Intravenous administration of medicine
4.1
14.2
42
113
L28
ICPC
Limited function/disability (L)
2.8
14.1
88
376
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
13.8
131
684
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.3
13.6
56
189
K92.1
ICD-10 Finland
Melaena
3.9
13.0
40
111
A10AE04
ATC
insulin glargine; parenteral
3.1
12.7
58
208
F05.9
ICD-10 Finland
Delirium, unspecified
10.6
12.7
24
24
JJC00
NOMESCO Finland
Allogenic transplantation of liver
72.4
12.7
14
*
127
Kela drug reimbursment
Transplant complication
13.8
12.6
21
16
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
5.0
12.3
27
57
G41.9
ICD-10 Finland
Status epilepticus, unspecified
39.0
12.3
15
*
Z94.4
ICD-10 Finland
Liver transplant status
39.0
12.3
15
*
103
Kela drug reimbursment
Diabetes, insulin-treated
2.3
12.1
128
694
UJD02
NOMESCO Finland
Gastroscopy
4.3
12.1
32
79
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.1
12.0
54
192
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.7
11.9
39
113
N05AH03
ATC
olanzapine; systemic
3.9
11.8
36
99
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.5
11.8
43
134
N05BA09
ATC
clobazam; oral
23.8
11.7
16
7
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.7
11.6
39
115
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.6
11.3
78
348
R50.9
ICD-10 Finland
Fever, unspecified
2.6
11.2
75
330
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
12.4
11.0
19
16
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.3
10.9
113
603
SPAT1229
SPAT
Assessment of need for aid
3.4
10.9
41
130
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.2
10.8
113
605
JN4AD
NOMESCO Finland
Body CT examination
2.9
10.8
55
209
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
5.0
10.6
23
48
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.3
10.6
43
143
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.5
10.5
38
118
L04AA06
ATC
mycophenolic acid; systemic
9.2
10.4
21
24
P15
ICPC
Chronic alcohol abuse
4.9
10.4
23
49
B03BA03
ATC
hydroxocobalamin; parenteral
3.8
10.3
33
94
SPAT1262
SPAT
Handing over of treatment supplies
2.4
10.2
82
391
Z2445
NOMESCO Finland
Psychologist
5.0
10.1
22
46
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.3
10.0
40
132
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
12.7
9.9
17
14
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
12.7
9.9
17
14
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
4.7
9.9
23
51
N03AX18
ATC
lacosamide; systemic
26.8
9.9
13
5
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
7.7
9.8
22
30
N05BA01
ATC
diazepam; systemic, rectal
2.6
9.8
63
271
R13
ICD-10 Finland
Dysphagia
3.4
9.8
37
118
J01MA02
ATC
ciprofloxacin; systemic
2.0
9.7
158
995
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.5
9.7
69
311
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
56.5
9.7
11
*
R11
ICD-10 Finland
Nausea and vomiting
3.0
9.6
44
158
F10.20
ICD-10 Finland
Alcohol dependence currently independent
7.9
9.6
21
28
R1250
NOMESCO Finland
Evaluation of functional capability
5.4
9.5
19
37
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
30.9
9.5
12
*
K70.1
ICD-10 Finland
Alcoholic hepatitis
22.4
9.4
13
6
N03AX12
ATC
[U] gabapentin; oral
2.4
9.4
76
363
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.7
9.4
53
213
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.6
9.4
60
257
N06AX11
ATC
mirtazapine; oral
2.0
9.3
132
789
ZX120
NOMESCO Finland
Intravenous
2.8
9.3
48
184
WX730
NOMESCO Finland
Conventional respirator
14.1
9.3
15
11
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
11.9
9.2
16
14
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.1
9.1
39
134
D97
ICPC
Liver disease NOS
16.1
9.1
14
9
WX892
NOMESCO Finland
Monitored bed care
3.0
9.0
41
146
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.3
8.9
77
378
N02AA05
ATC
oxycodone; systemic
2.2
8.9
86
443
N03AE01
ATC
clonazepam; systemic
3.5
8.8
31
94
N06AX16
ATC
venlafaxine; oral
2.6
8.8
57
245
W19
ICD-10 Finland
Unspecified fall
2.8
8.7
46
178
A86
ICD-10 Finland
Unspecified viral encephalitis
51.2
8.7
10
*
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
4.2
8.7
23
57
WX704
NOMESCO Finland
Intubation
3.2
8.6
36
122
TPH07
NOMESCO Finland
Cathetrisation of artery
2.6
8.6
54
229
E66.9
ICD-10 Finland
Obesity, unspecified
4.6
8.5
20
45
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
4.2
8.5
23
58
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
92.1
8.4
9
*
A10AE05
ATC
insulin detemir; parenteral
3.5
8.4
30
92
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
8.1
93
510
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
8.1
184
1275
N03AX16
ATC
[U] pregabalin
2.1
8.1
95
527
N19
ICD-10 Finland
Unspecified kidney failure
3.9
8.0
24
65
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
8.0
92
505
SPAT1216
SPAT
Assessment of functional ability
2.3
7.9
67
325
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
7.8
71
355
G41.2
ICD-10 Finland
Complex partial status epilepticus
46.0
7.7
9
*
G40.4
ICD-10 Finland
Other generalized epilepsy and epileptic syndromes
46.0
7.7
9
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.6
7.7
46
190
A10BA02
ATC
metformin; oral
1.9
7.7
119
726
F10.25
ICD-10 Finland
Alcohol dependence continuous use
8.3
7.7
16
20
A46
ICD-10 Finland
Erysipelas
2.3
7.6
65
316
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.3
7.6
20
49
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.8
7.6
23
63
E87.6
ICD-10 Finland
Hypokalaemia
3.8
7.6
23
63
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.3
7.6
61
290
E87.5
ICD-10 Finland
Hyperkalaemia
6.7
7.5
18
28
R55
ICD-10 Finland
Syncope and collapse
2.5
7.5
52
231
SPAT1254
SPAT
Administration of medicine
2.3
7.5
63
305
Z51.5
ICD-10 Finland
Palliative care
2.7
7.5
41
162
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
81.7
7.4
8
*
N03AF01
ATC
carbamazepine; oral, rectal
3.2
7.4
30
100
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
+∞
7.3
7
*
G93.8
ICD-10 Finland
Other specified disorders of brain
+∞
7.3
7
*
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
+∞
7.3
7
*
M04AA01
ATC
allopurinol; systemic
2.2
7.2
64
316
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.9
7.2
21
56
N05CF01
ATC
zopiclone; oral
1.9
7.2
128
815
N05BA04
ATC
oxazepam; oral
2.0
7.2
100
587
A10BH05
ATC
linagliptin; oral
3.3
7.0
27
87
N06AB04
ATC
citalopram; systemic
2.1
7.0
79
429
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
6.0
7.0
18
31
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
7.0
69
356
C07AG02
ATC
carvedilol; oral
2.9
6.9
33
121
Z49.1
ICD-10 Finland
Extracorporeal dialysis
8.5
6.9
14
17
L04AD02
ATC
tacrolimus; systemic
11.2
6.8
12
11
ZXD05
NOMESCO Finland
Urgent procedure
1.9
6.8
114
710
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
7.4
6.8
15
21
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
3.9
6.7
20
54
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.2
6.7
60
298
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.6
6.7
22
64
N05CD07
ATC
temazepam; oral
2.3
6.6
56
271
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.3
6.6
17
41
T90
ICPC
Diabetes non-insulin dependent
1.9
6.6
98
586
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
3.8
6.6
20
55
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
4.1
6.5
18
46
R60.0
ICD-10 Finland
Localized oedema
2.3
6.5
53
253
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.2
6.5
59
295
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
5.4
6.4
18
35
N03AX09
ATC
lamotrigine; oral
3.6
6.4
21
61
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
3.6
6.4
21
61
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
3.6
6.4
21
61
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
8.4
6.4
13
16
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
6.1
6.4
16
27
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
11.3
6.3
11
10
N17.8
ICD-10 Finland
Other acute renal failure
11.3
6.3
11
10
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
18.4
6.3
9
5
K90
ICPC
Stroke/cerebrovascular accident
5.2
6.3
18
36
G93.99
ICD-10 Finland
Disorder of brain, unspecified
+∞
6.3
6
*
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
+∞
6.3
6
*
G91.0
ICD-10 Finland
Communicating hydrocephalus
+∞
6.3
6
*
WX882
NOMESCO Finland
High dependency care
4.1
6.2
17
43
A10AC01
ATC
insulin (human); parenteral
2.6
6.2
37
153
L04AD01
ATC
ciclosporin; systemic
7.9
6.2
13
17
N30.0
ICD-10 Finland
Acute cystitis
2.2
6.1
53
259
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.4
6.1
22
68
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.3
6.1
46
212
K76.9
ICD-10 Finland
Liver disease, unspecified
6.9
6.1
14
21
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
6.2
6.1
15
25
F03
ICD-10 Finland
Unspecified dementia
3.2
6.0
24
79
WW500
NOMESCO Finland
Blood transfusion
3.2
6.0
24
79
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
112
61
25.90
147.00
11.5
2.7
50.83
32.58
umol/l
5.63
103
55
110
253
5.76
47.77
15.0
7.3
11.45
9.88
mmol/l
1.31
105
241
51
58
10.04
42.05
1.8
1.6
3.42
10.42
e6/l
0.72
43
45
130
380
4.73
41.95
10.9
5.9
1.10
1.05
mmol/l
0.85
124
351
35
25
15.36
38.72
1.8
1.2
—
—
—
0
0
105
287
4.71
36.38
5.1
2.2
0.16
0.21
g/l
9.46
99
267
92
268
4.24
28.81
5.8
4.6
1.43
1.72
mmol/l
0.26
76
217
126
472
3.53
27.20
5.9
3.0
0.77
0.82
mmol/l
3.09
119
444
176
919
2.75
20.01
5.4
2.5
65.80
62.28
u/l
0.16
167
845
93
356
3.15
18.63
9.7
3.2
22.82
8.35
umol/l
1.37
84
316
213
1258
2.63
18.41
15.0
5.0
31.79
35.49
g/l
13.77
204
1176
31
53
6.29
17.74
1.2
1.1
349.77
323.50
u/ml
0.12
22
28
87
331
3.13
17.52
13.0
7.6
1.03
1.18
mmol/l
0.12
72
262
24
32
7.95
17.16
1.2
1.0
—
—
—
0
0
121
562
2.71
16.81
1.8
1.7
1261.40
1136.09
nmol/l
0.59
99
418
84
321
3.09
16.73
2.7
1.7
1.79
1.52
%
2.21
74
276
102
436
2.85
16.60
4.0
2.3
2.16
2.31
g/l
1.51
97
403
33
64
5.56
16.59
7.7
7.9
1757.50
259.64
iu/ml
—
6
11
110
492
2.76
16.40
2.7
1.9
—
—
—
0
0
227
1433
2.51
16.30
16.0
7.0
1.20
1.21
mmol/l
1.77
206
1212
28
23
13.07
16.13
1.3
1.1
—
—
—
0
0
36
78
5.01
16.01
1.4
1.3
—
—
—
0
0
97
411
2.84
15.99
4.2
2.4
24.09
22.36
%
0.43
81
355
30
56
5.74
15.69
1.2
1.1
—
—
—
0
0
85
340
2.95
15.54
3.8
4.6
233.04
276.49
u/l
1.22
77
323
23
13
18.76
15.35
4.1
1.5
1125.53
8664.50
e6/l
—
15
6
221
1407
2.42
15.15
21.3
15.4
1.24
1.28
inr
0.34
62
393
23
14
17.42
14.96
1.4
1.1
—
—
—
0
0
21
10
22.16
14.82
4.5
2.8
69.19
107.40
%
—
21
10
23
35
6.94
14.64
1.2
1.0
—
—
—
0
0
23
15
16.26
14.60
1.2
1.1
1.86
1.77
mmol/l
0.25
23
15
21
11
20.15
14.40
1.5
1.2
—
—
—
0
0
60
210
3.22
13.72
2.5
1.5
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
22
17
13.68
13.09
1.5
1.1
—
—
—
0
0
135
734
2.32
12.82
3.1
2.0
3.54
3.17
mg/l
0.64
126
627
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
35
89
4.24
12.76
4.7
2.4
0.23
0.35
u/ml
1.99
21
46
31
75
4.42
12.04
3.4
1.5
—
—
—
0
0
77
333
2.66
11.92
2.5
1.9
—
—
—
0
0
202
1328
2.15
11.67
15.4
6.2
1.20
1.21
mmol/l
2.42
193
1203
58
222
2.91
11.29
8.8
3.9
2.12
1.84
mmol/l
0.18
42
165
76
340
2.55
10.93
2.6
1.9
—
—
—
0
0
177
1148
2.04
10.16
4.6
2.6
160.37
155.87
ug/l
0.10
169
1047
78
370
2.40
9.83
12.2
7.3
104.21
104.16
mmol/l
0.02
78
370
237
1723
2.04
9.71
13.4
4.8
7.40
6.79
mmol/l
2.48
229
1622
28
75
3.96
9.52
2.6
3.0
207.25
188.43
%
0.41
28
70
20
26
8.07
9.26
1.1
1.0
—
—
—
0
0
30
87
3.66
9.13
1.4
1.4
307.82
292.68
ug/g
0.14
17
46
105
585
2.11
8.89
1.9
1.8
477.01
20083235.64
pmol/l
0.79
91
483
17
20
8.85
8.39
1.4
1.0
—
—
—
0
0
247
1880
1.94
8.18
6.9
4.2
89.75
1191.61
e6/l
—
8
28
14
12
12.07
8.14
1.1
1.3
—
—
—
0
0
58
262
2.44
8.06
1.9
1.9
485.10
383.24
nmol/l
0.41
58
238
11
5
22.60
8.06
2.8
2.4
40327.27
27881.00
ug/l
—
11
5
114
676
1.99
8.04
1.9
1.6
19.47
20.02
nmol/l
0.14
104
571
164
1107
1.86
7.77
3.1
2.2
68.18
75.25
nmol/l
2.11
153
979
221
1647
1.85
7.53
14.3
9.8
3.89
4.16
e9/l
1.06
208
1434
43
174
2.66
7.49
1.6
1.4
—
—
—
0
0
47
199
2.56
7.48
5.0
3.9
115.14
92.90
ng/l
0.49
42
172
13
12
11.18
7.35
2.1
1.1
—
—
—
0
0
11
7
16.13
7.27
1.3
1.0
—
—
—
0
0
115
706
1.91
7.22
4.4
2.4
—
—
—
0
0
22
61
3.77
7.14
1.8
1.4
—
—
—
0
0
94
541
1.99
7.12
4.6
3.6
303.51
358.45
ng/l
0.08
75
438
141
930
1.83
7.03
4.0
3.1
6.87
7.90
mmol/l
2.29
129
771
17
27
6.54
7.02
1.4
1.1
—
—
—
0
0
158
1084
1.80
6.89
4.8
3.1
—
—
—
0
0
17
41
4.30
6.62
1.5
1.2
—
—
—
0
0
30
107
2.96
6.59
3.0
2.7
—
—
—
0
0
102
620
1.89
6.51
2.0
1.8
2.15
1.37
mg/l
0.80
82
484
41
174
2.53
6.49
17.6
9.7
93.97
94.27
%
0.12
41
174
27
92
3.09
6.41
1.5
1.3
—
—
—
0
0
165
1166
1.75
6.37
2.6
2.0
92.50
92.93
pmol/l
0.04
93
610
186
1363
1.73
6.28
9.4
6.2
25.89
27.30
%
0.91
181
1281
183
1338
1.73
6.21
4.7
2.7
—
—
—
0
0
18
48
3.89
6.16
1.7
1.8
—
—
—
0
0
18
48
3.89
6.16
1.7
1.8
—
—
—
0
0
20
58
3.59
6.10
2.0
1.5
—
—
—
0
0
11
11
10.26
6.07
1.4
1.1
—
—
—
0
0
11
11
10.26
6.07
1.4
1.1
—
—
—
0
0
12
15
8.23
5.88
1.5
1.0
—
—
—
0
0
54
274
2.14
5.68
5.9
2.6
32.59
31.99
u/l
0.04
49
231
36
154
2.48
5.61
10.8
4.3
24.33
24.74
mmol/l
0.27
36
144
94
581
1.83
5.61
1.4
1.3
1.07
1.67
u/ml
0.60
21
147
10
10
10.24
5.56
1.5
1.1
—
—
—
0
0
10
10
10.24
5.56
1.4
1.1
—
—
—
0
0
29
113
2.70
5.44
2.4
1.6
—
—
—
0
0
10
11
9.30
5.32
1.4
1.1
—
—
—
0
0
5
0
+∞
5.22
1.2
0.0
—
—
—
0
0
242
2816
0.59
5.12
5.0
4.5
1.27
1.42
mmol/l
7.52
227
2577
22
77
2.97
5.01
1.7
2.4
—
—
—
0
0
245
2837
0.60
4.99
5.0
4.5
4.18
4.59
mmol/l
9.61
230
2621
252
2897
0.59
4.97
5.6
5.0
2.43
2.72
mmol/l
6.43
234
2645
269
2254
1.71
4.96
20.2
7.8
100.16
80.53
u/l
6.06
260
2107
21
72
3.03
4.96
1.9
1.7
—
—
—
0
0
15
33
4.69
4.92
1.7
1.8
—
—
—
0
0
15
33
4.69
4.92
1.7
1.8
—
—
—
0
0
30
126
2.50
4.87
1.8
2.2
43.53
38.44
u/l
0.49
25
113
32
139
2.43
4.84
4.7
3.2
0.63
0.65
%
0.20
32
139
8
7
11.64
4.80
1.0
1.1
—
—
—
0
0
29
122
2.49
4.69
2.9
1.8
—
—
—
0
0
20
69
3.01
4.68
1.3
1.1
—
—
—
0
0
39
189
2.19
4.60
2.0
1.7
—
—
—
0
0
7
5
14.23
4.59
1.0
1.2
—
—
—
0
0
8
8
10.19
4.54
1.5
1.0
1026.50
1248.00
miu/ml
—
8
8
27
112
2.52
4.50
1.7
2.8
—
—
—
0
0
18
60
3.10
4.46
1.9
1.3
—
—
—
0
0
18
60
3.10
4.46
1.9
1.3
—
—
—
0
0
132
946
1.61
4.46
4.8
3.7
16.69
9.19
mg/mmol
0.81
109
623
20
72
2.88
4.36
2.0
1.7
—
—
—
0
0
42
217
2.06
4.22
4.5
2.8
60.09
64.07
ml/min/173m2
0.25
22
95
45
775
0.52
4.10
2.4
2.9
0.47
0.76
ug/l
7.36
29
526
10
18
5.68
4.00
1.5
1.4
—
—
—
0
0
14
37
3.89
3.93
1.5
1.9
—
—
—
0
0
11
23
4.90
3.90
1.0
1.0
—
—
—
0
0
11
23
4.90
3.90
2.3
1.3
0.86
1.01
g/l
0.57
11
23
11
23
4.90
3.90
3.5
2.3
—
—
—
0
0
23
97
2.46
3.73
2.1
3.3
1.01
1.03
g/l
0.01
18
86
17
62
2.83
3.64
1.3
1.3
—
—
—
0
0
128
949
1.53
3.59
5.4
3.5
2.32
2.35
mmol/l
1.62
113
837
227
1897
1.51
3.58
10.7
3.2
100.25
52.33
u/l
5.01
218
1768
15
52
2.96
3.50
1.5
1.5
—
—
—
0
0
109
784
1.55
3.50
4.8
2.9
8201.34
9640.91
umol/l
0.09
98
667
148
1138
1.50
3.48
6.2
3.8
29.92
48.05
ng/l
1.88
126
833
21
88
2.47
3.46
1.6
1.2
0.90
4.42
u/ml
—
6
6
7
10
7.11
3.37
2.1
2.1
—
—
—
0
0
123
915
1.52
3.36
3.0
3.0
1612.12
1459.64
ng/l
0.17
108
778
55
336
1.75
3.34
3.0
4.4
20.34
44.06
ug/l
0.41
46
279
9
19
4.83
3.26
1.1
1.4
—
—
—
0
0
10
24
4.25
3.21
1.2
1.2
—
—
—
0
0
113
834
1.51
3.18
4.2
3.1
0.74
0.64
e6/l
0.17
93
632
13
44
3.03
3.16
1.5
1.6
—
—
—
0
0
14
50
2.87
3.12
1.9
1.5
—
—
—
0
0
17
68
2.57
3.08
1.5
1.4
—
—
—
0
0
8
16
5.08
3.06
1.3
1.6
—
—
—
0
0
8
16
5.08
3.06
1.4
1.1
—
—
—
0
0
5
5
10.11
2.98
1.0
1.2
—
—
—
0
0
5
5
10.11
2.98
1.2
1.2
—
—
—
0
0
8
17
4.78
2.93
2.6
2.2
—
—
—
0
0
243
2725
0.68
2.91
4.4
4.0
1.37
1.31
mmol/l
0.63
224
2476
8
223
0.34
2.89
1.3
1.8
—
—
—
0
0
18
77
2.41
2.86
1.7
1.5
—
—
—
0
0
243
2110
1.44
2.80
7.0
4.1
19.49
12.75
mm/h
5.62
230
1923
5
6
8.42
2.75
1.6
1.0
—
—
—
0
0
5
6
8.42
2.75
1.6
1.0
—
—
—
0
0
7
14
5.07
2.74
1.1
1.0
—
—
—
0
0
9
24
3.82
2.69
1.2
1.6
20.89
13.62
u/l
—
9
24
19
87
2.25
2.62
1.5
1.7
—
—
—
0
0
12
45
2.72
2.47
2.2
1.6
—
—
—
0
0
73
517
1.51
2.46
3.3
2.7
2.48
0.98
e6/l
0.90
48
305
235
2056
1.39
2.40
4.4
3.6
14.56
14.87
pmol/l
0.99
217
1834
8
22
3.69
2.37
3.7
2.0
0.22
0.14
e9/l
—
8
17
10
34
2.99
2.30
2.2
1.8
—
—
—
0
0
8
23
3.53
2.28
3.8
2.0
569.75
489.47
e6/l
—
8
17
8
23
3.53
2.28
1.3
1.6
—
—
—
0
0
13
55
2.41
2.14
2.2
1.8
—
—
—
0
0
14
62
2.31
2.10
1.0
1.1
56.64
28.06
u/l
0.36
14
53
11
43
2.60
2.09
1.5
1.1
—
—
—
0
0
47
314
1.57
2.06
5.4
3.3
—
—
—
0
0
83
1072
0.71
2.03
3.4
4.4
18.31
21.86
%
1.40
35
525
8
26
3.12
2.02
1.5
1.1
—
—
—
0
0
10
39
2.61
1.95
1.0
1.0
—
—
—
0
0
6
16
3.79
1.94
1.7
1.9
0.80
1.18
nmol/l
—
6
11
18
94
1.96
1.83
1.6
1.4
0.00
0.05
iu/ml
—
5
22
14
69
2.07
1.67
5.4
2.3
130.00
129.79
g/l
0.01
14
53
7
25
2.83
1.65
1.4
1.2
—
—
—
0
0
7
25
2.83
1.65
1.4
1.2
—
—
—
0
0
65
487
1.41
1.65
4.1
2.9
4.11
1.73
e6/l
0.66
41
277
306
3214
0.72
1.50
55.4
21.7
125.77
136.36
g/l
17.72
300
3161
306
3212
0.73
1.47
54.9
21.6
4.15
4.52
e12/l
17.38
299
3109
9
38
2.40
1.46
1.9
1.6
—
—
—
0
0
13
66
2.01
1.45
8.0
2.7
16.41
16.24
%
—
8
37
9
39
2.34
1.44
1.8
1.6
—
—
—
0
0
9
39
2.34
1.44
1.8
1.6
—
—
—
0
0
9
39
2.34
1.44
2.0
1.6
—
—
—
0
0
9
39
2.34
1.44
2.0
1.6
—
—
—
0
0
306
3210
0.73
1.43
55.6
21.7
37.32
40.35
%
8.16
279
3006
92
745
1.31
1.42
6.6
3.9
0.00
0.01
estimate
0.50
21
233
252
2712
0.78
1.42
35.0
13.8
73.45
79.30
ml/min/173m2
2.76
217
2241
9
40
2.28
1.41
1.8
1.6
—
—
—
0
0
157
1368
1.26
1.35
5.4
3.7
0.00
0.00
estimate
0.50
26
262
8
34
2.38
1.30
1.5
1.9
—
—
—
0
0
70
555
1.32
1.26
3.7
3.2
2.49
2.45
mmol/l
1.19
57
486
263
2802
0.79
1.25
5.7
4.7
6.58
6.03
mmol/l
5.69
246
2541
115
1340
0.79
1.25
3.2
5.0
1.46
3.24
ug/l
2.51
101
1193
5
20
2.52
1.15
1.8
1.6
—
—
—
0
0
5
20
2.52
1.15
1.8
1.6
—
—
—
0
0
7
30
2.36
1.13
2.7
1.7
—
—
—
0
0
8
41
1.97
1.09
2.6
1.7
—
—
—
0
0
153
1359
1.21
1.05
6.6
5.1
0.00
0.00
estimate
-0.00
24
246
9
46
1.98
1.04
4.6
2.9
105.78
105.26
mmol/l
—
9
46
5
22
2.29
1.03
1.4
1.6
—
—
—
0
0
154
1379
1.20
0.95
5.3
3.7
0.00
0.00
estimate
-0.00
22
228
21
143
1.50
0.92
1.1
1.2
52.09
134.54
iu/ml
2.36
11
54
6
28
2.16
0.92
1.3
1.2
—
—
—
0
0
6
30
2.02
0.87
1.8
1.7
—
—
—
0
0
6
30
2.02
0.87
1.8
1.7
—
—
—
0
0
6
30
2.02
0.87
1.8
1.7
—
—
—
0
0
66
788
0.80
0.87
2.0
1.7
1.58
1.41
mmol/l
0.52
58
656
257
2709
0.83
0.86
8.8
5.9
42.34
40.30
mmol/mol
1.78
245
2511
6
31
1.95
0.84
1.2
1.1
—
—
—
0
0
13
81
1.63
0.82
1.4
1.3
—
—
—
0
0
6
34
1.78
0.76
3.5
5.0
—
—
—
0
0
120
1071
1.18
0.75
6.2
3.9
—
—
—
0
0
5
26
1.94
0.71
1.0
1.3
11.80
10.62
u/l
—
5
26
9
58
1.57
0.70
1.4
1.3
—
—
—
0
0
300
2889
1.20
0.69
40.7
14.6
21.91
25.37
mg/l
1.68
274
2294
5
29
1.73
0.64
1.0
1.4
—
—
—
0
0
5
30
1.68
0.61
1.6
1.8
—
—
—
0
0
6
39
1.55
0.53
1.2
1.1
—
—
—
0
0
12
83
1.46
0.52
1.7
1.5
—
—
—
0
0
12
84
1.44
0.50
1.6
1.6
—
—
—
0
0
50
431
1.19
0.48
1.3
1.3
64.79
38.94
iu/ml
0.41
15
141
43
367
1.19
0.46
10.9
7.0
—
—
—
0
0
10
69
1.46
0.44
1.0
1.1
—
3.97
—
0
7
5
32
1.57
0.42
1.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
4.1
—
256.38
—
0
16
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
0
17
0.00
0.40
0.0
1.6
—
—
—
0
0
0
17
0.00
0.40
0.0
1.4
—
—
—
0
0
301
3076
0.88
0.37
24.1
10.6
29.38
26.92
u/l
1.27
293
2969
46
410
1.14
0.31
1.3
1.3
31.47
13.91
u/ml
0.35
18
146
171
1635
1.09
0.31
3.3
2.7
—
—
—
0
0
7
56
1.25
0.29
1.3
1.6
—
—
—
0
0
264
2574
1.09
0.29
5.3
4.3
1.98
1.96
mu/l
0.08
244
2306
8
64
1.26
0.27
1.1
1.5
—
—
—
0
0
11
138
0.79
0.26
1.1
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
287.33
—
0
6
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
6
48
1.25
0.20
4.5
3.2
52.83
56.31
%
—
6
48
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
7
59
1.19
0.18
1.1
1.3
—
271.83
miu/ml
—
0
22
42
388
1.09
0.17
4.7
4.4
28.89
31.00
%
0.75
35
257
8
70
1.15
0.16
1.3
1.7
—
—
—
0
0
28
305
0.91
0.14
1.4
1.5
—
—
—
0
0
43
410
1.06
0.09
1.3
1.5
—
—
—
0
0
9
86
1.05
0.07
1.1
1.2
—
—
—
0
0
9
86
1.05
0.07
1.1
1.2
—
—
—
0
0
17
183
0.93
0.06
1.5
1.9
—
—
—
0
0
29
277
1.05
0.05
2.6
2.2
15.49
13.09
nmol/l
0.56
24
251
16
162
0.99
0.00
1.6
1.8
—
—
—
0
0
14
145
0.96
0.00
1.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
68
0.88
-0.00
1.8
2.0
153.17
228.87
pmol/l
—
6
61
Mortality – FinRegistry
↥Association
Association between endpoint G6_ENCEPATH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ENCEPATH | 5.197 [4.2, 6.43] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.725 |
During the follow-up period (1.1.1998 — 31.12.2019), 510 out of 1064 females with G6_ENCEPATH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ENCEPATH | 4.951 [4.13, 5.93] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 805 out of 1493 males with G6_ENCEPATH died.
Mortality risk
Mortality risk for people of age
years, who have G6_ENCEPATH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.537% | 0.72% |
| 5 | 3.665% | 5.005% |
| 10 | 8.454% | 11.984% |
| 15 | 15.556% | 22.374% |
| 20 | 26.651% | 35.56% |
Relationships between endpoints
↥Index endpoint: G6_ENCEPATH – Encephalopathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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