Complications following myocardial infarction

I9_MI_COMPLICATIONS

myocardial infarction: Gross necrosis of the myocardium, as a result of interruption of the blood supply to the area, as in coronary thrombosis.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 I23
  • Cause of death: ICD-10 I23

2 out of 7 registries used, show all original rules.

309

4. Check minimum number of events

None

309

5. Include endpoints

None

309

6. Filter based on genotype QC (FinnGen only)

309

Control definitions (FinnGen only)

Control exclude
I9_ISCHHEART

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I20-I25
Name in latin
Aliquae complicationes post infarctum myocardii acutum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4502 1945 2459
Only index persons 2275 934 1341
Unadjusted period prevalence (%)
Whole population 0.06 0.06 0.07
Only index persons 0.04 0.03 0.05
Median age at first event (years)
Whole population 74.10 77.64 71.22
Only index persons 72.79 77.27 69.66

-FinnGen-

Key figures

All Female Male
Number of individuals 309 83 226
Unadjusted period prevalence (%) 0.08 0.03 0.10
Median age at first event (years) 71.35 72.11 71.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
276
Matched controls
2758
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I23.0
ICD-10 Finland
Haemopericardium as current complication following acute myocardial infarction
+∞
172.6
147
*
I25.1
ICD-10 Finland
Atherosclerotic heart disease
135.2
105.5
108
13
I25.2
ICD-10 Finland
Old myocardial infarction
310.8
72.0
70
*
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
28.8
69.3
96
50
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
15.3
57.0
101
100
I21.9
ICD-10 Finland
Acute myocardial infarction, unspecified
+∞
48.4
45
*
I21.0
ICD-10 Finland
Acute transmural myocardial infarction of anterior wall
+∞
42.8
40
*
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
59.2
42.4
49
10
FN1AT
NOMESCO Finland
Endovascular dilatation of coronary arteries (PTCA)
+∞
41.7
39
*
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
394.6
35.8
35
*
AN1
HP
Coronary angiography
15.0
34.5
59
49
FN1YT
NOMESCO Finland
Percutaneous insertion of coronary artery stent
+∞
33.0
31
*
I21.2
ICD-10 Finland
Acute transmural myocardial infarction of other sites
+∞
30.8
29
*
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
+∞
29.7
28
*
I21.1
ICD-10 Finland
Acute transmural myocardial infarction of inferior wall
+∞
29.7
28
*
I23.8
ICD-10 Finland
Other current complications following acute myocardial infarction
+∞
29.7
28
*
I23.1
ICD-10 Finland
Atrial septal defect as current complication following acute myocardial infarction
+∞
29.7
28
*
I23.2
ICD-10 Finland
Ventricular septal defect as current complication following acute myocardial infarction
+∞
29.7
28
*
I23.6
ICD-10 Finland
Thrombosis of atrium, auricular appendage, and ventricle as current complications following acute myocardial infarction
+∞
28.6
27
*
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
36.2
27.6
35
11
81
HP
Angiography of the heart and coronary arteries
23.5
26.0
37
18
FNA01
NOMESCO Finland
Anastomosis to coronary artery from internal mammary artery, one distal anastamosis
+∞
24.3
23
*
I21.01
ICD-10 Finland
Acute transmural myocardial infarction of anterior wall
+∞
23.2
22
*
C01DA14
ATC
isosorbide mononitrate; oral
6.0
23.1
69
144
I20.99
ICD-10 Finland
Angina pectoris, unspecified
249.8
23.0
23
*
I20.09
ICD-10 Finland
Unstable angina
+∞
22.2
21
*
FN2BA
NOMESCO Finland
Percutaneous transluminal coronary angioplasty with stent (includes balloon pre-dilation)
+∞
21.1
20
*
I21.41
ICD-10 Finland
Acute subendocardial infarction stenosed coronary artery
+∞
20.0
19
*
I21.99
ICD-10 Finland
Myocardial infarction (acute) UNS unspecified coronary artery status
+∞
20.0
19
*
I21.19
ICD-10 Finland
Acute transmural myocardial infarction of inferior wall
+∞
20.0
19
*
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
79.1
20.0
22
*
I21.49
ICD-10 Finland
Acute subendocardial infarction unspecified coronary artery status
+∞
19.0
18
*
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
3.9
18.2
87
290
I21.00
ICD-10 Finland
Acute transmural myocardial infarction of anterior wall
+∞
17.9
17
*
I20.90
ICD-10 Finland
Angina pectoris, unspecified
+∞
17.9
17
*
I21.09
ICD-10 Finland
Acute transmural myocardial infarction of anterior wall
+∞
16.8
16
*
I20.00
ICD-10 Finland
Unstable angina
+∞
16.8
16
*
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
3.9
16.7
77
247
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
20.7
15.8
23
12
I20.01
ICD-10 Finland
Unstable angina
+∞
15.8
15
*
Z95.5
ICD-10 Finland
Presence of coronary angioplasty implant and graft
60.1
15.0
17
*
AN3
HP
Balloon angioplasty and metallic stent
+∞
14.7
14
*
11
HP
Coronary artery bypass surgery
+∞
14.7
14
*
B01AC04
ATC
clopidogrel; oral
4.5
14.7
55
144
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
20.5
14.5
21
11
I21.90
ICD-10 Finland
Myocardial infarction (acute) UNS no detected stenosis of the coronary artery
+∞
13.6
13
*
82
HP
Single vessel balloon catheter extension
+∞
13.6
13
*
AN2
HP
Balloon angioplasty, including several vessels
+∞
12.6
12
*
AA1
HP
Conventional CABG
+∞
12.6
12
*
I21.10
ICD-10 Finland
Acute transmural myocardial infarction of inferior wall
+∞
12.6
12
*
B01AC06
ATC
acetylsalicylic acid; oral (platelet aggregation inhibitors excl. heparin)
16.9
12.3
19
12
FNC20
NOMESCO Finland
Aorto-coronary venous bypass with two distal anastomoses
+∞
11.5
11
*
I23.5
ICD-10 Finland
Rupture of papillary muscle as current complication following acute myocardial infarction
+∞
11.5
11
*
4100X
ICD-9 Finland
Acute myocardial infarction, Of anterolateral wall[INFARCTUS MYOCARDII ACUTUS DEFINITUS,MÄÄRITTELEMÄT]
+∞
11.5
11
*
FXG00
NOMESCO Finland
Insertion and use of IABP
+∞
11.5
11
*
B01AA03
ATC
warfarin; systemic
2.6
11.0
98
478
I25.5
ICD-10 Finland
Ischaemic cardiomyopathy
114.1
10.5
11
*
I21.11
ICD-10 Finland
Acute transmural myocardial infarction of inferior wall
+∞
10.5
10
*
I20.89
ICD-10 Finland
Other angina pectoris unspecified coronary artery status
57.0
9.7
11
*
I21.40
ICD-10 Finland
Acute subendocardial infarction no detected stenosis of the coronary artery
103.4
9.5
10
*
FHA20
NOMESCO Finland
Closure of VSR in posteroseptal myocardial infarction
+∞
9.4
9
*
A98
ICPC
Health maint/preventive medicine
0.5
9.2
128
1811
FNC10
NOMESCO Finland
Aorto-coronary venous bypass with single distal anastomosis
+∞
8.4
8
*
AN4
HP
Balloon angioplasty and drug eluding stent
+∞
8.4
8
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
8.3
54
215
201
Kela drug reimbursment
Chronic cardiac insufficiency
4.1
7.9
30
80
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.8
7.8
52
211
I47.2
ICD-10 Finland
Ventricular tachycardia
12.3
7.7
13
11
R07.4
ICD-10 Finland
Chest pain, unspecified
2.5
7.4
61
280
FNC30
NOMESCO Finland
Aorto-coronary venous bypass with three distal anastomoses
+∞
7.3
7
*
I23.3
ICD-10 Finland
Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
+∞
7.3
7
*
I23
ICD-10 Finland
Certain current complications following acute myocardial infarction
+∞
7.3
7
*
C08CA07
ATC
nisoldipine; oral
30.9
7.2
9
*
AP1
HP
Catheterization of the left side of the heart
20.7
7.2
10
5
I25
ICD-10 Finland
Chronic ischaemic heart disease
20.7
7.2
10
5
C09AA05
ATC
ramipril; oral
2.2
7.0
82
445
N02BE01
ATC
paracetamol; systemic, rectal
0.5
6.8
136
1809
61
HP
Catheterization and pressure measurement of the left side of the heart
23.2
6.7
9
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
4.2
6.4
23
59
FN1BT
NOMESCO Finland
Extensive endovascular dilatation of coronary (PTCA) arteries
+∞
6.3
6
*
AM2
HP
Surgery of infarction complication eg VSR, aneurysm, rupture of papillary muscle
+∞
6.3
6
*
B01AC24
ATC
ticagrelor; oral
+∞
6.3
6
*
C07AB02
ATC
metoprolol; systemic
2.2
6.1
69
365

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
149
2026
0.49
8.69
12.0
10.5
29.0
24.6
u/l
0.59
135
1915
159
2106
0.50
8.37
33.6
23.6
7.6
7.0
e9/l
2.60
146
2009
159
2106
0.50
8.37
33.5
23.5
4.3
4.4
e12/l
0.91
146
2009
159
2106
0.50
8.37
33.5
23.4
30.4
30.5
pg
0.36
147
2035
159
2106
0.50
8.37
33.9
23.7
130.4
133.6
g/l
1.31
149
2033
159
2106
0.50
8.37
33.4
23.5
91.9
91.9
fl
0.05
147
2036
159
2105
0.50
8.33
33.5
23.6
226.3
235.8
e9/l
1.14
147
2017
144
1951
0.51
7.77
25.4
16.4
29.2
29.4
mg/l
0.03
117
1589
157
2054
0.52
7.28
29.6
18.9
139.7
139.6
mmol/l
0.15
144
1972
158
2062
0.52
7.25
29.8
18.9
4.1
4.0
mmol/l
1.23
143
1982
150
1986
0.52
7.16
21.6
15.3
—
—
—
0
0
29
696
0.36
6.94
2.6
3.2
1.2
0.8
ug/l
0.42
19
486
57
982
0.49
5.77
3.8
4.2
0.0
0.0
estimate
0.00
13
175
57
967
0.50
5.43
5.6
5.8
0.0
0.0
estimate
—
10
178
114
1570
0.57
5.39
9.6
7.5
88.6
83.2
u/l
0.56
101
1430
57
964
0.50
5.37
3.7
4.1
0.0
0.0
estimate
0.00
13
180
142
1841
0.58
5.31
5.2
4.8
2.3
2.7
mmol/l
4.34
125
1592
142
1839
0.58
5.27
4.7
4.8
6.5
6.1
mmol/l
2.40
116
1591
37
166
2.40
5.26
3.7
2.1
7.3
4.9
ug/l
0.60
28
132
136
1772
0.58
5.05
4.8
4.3
4.2
4.5
mmol/l
3.19
122
1555
104
1449
0.57
4.95
4.6
3.9
15.9
14.6
mm/h
0.34
90
1307
134
1748
0.59
4.95
4.8
4.4
1.3
1.4
mmol/l
3.01
119
1513
100
1404
0.57
4.87
4.4
4.7
—
—
—
0
0
130
1705
0.59
4.86
4.8
4.2
2.2
2.0
mu/l
0.28
108
1465
75
1138
0.55
4.83
3.9
5.6
2.7
3.3
ug/l
0.42
60
980
139
1790
0.59
4.81
6.8
6.3
44.1
40.8
mmol/mol
2.43
124
1589
97
1367
0.58
4.74
5.1
3.9
—
—
—
0
0
47
818
0.50
4.70
5.9
4.0
258.3
101.9
e6/l
0.61
34
605
112
1500
0.60
4.32
33.1
21.1
330.2
331.8
g/l
0.85
107
1476
111
1481
0.61
4.15
29.6
19.9
14.4
14.0
%
1.74
104
1435
133
1691
0.63
3.96
4.4
3.9
1.4
1.3
mmol/l
1.61
118
1447
129
1650
0.63
3.93
26.1
17.5
38.4
38.2
%
0.07
71
1006
28
545
0.47
3.77
3.6
4.0
—
—
—
0
0
24
491
0.45
3.69
1.4
1.3
—
—
—
0
0
50
797
0.56
3.59
2.6
2.3
—
—
—
0
0
45
735
0.55
3.51
4.7
3.5
70.2
85.1
e6/l
0.10
35
572
36
610
0.54
3.14
4.9
3.4
—
—
—
0
0
34
577
0.54
2.97
1.8
1.6
14.0
20.2
nmol/l
3.02
28
467
41
658
0.57
2.94
4.7
3.4
0.3
0.6
e6/l
0.65
29
501
28
502
0.51
2.92
3.5
2.9
554.8
577.8
mosm/kgh2o
0.42
23
418
50
759
0.59
2.91
3.5
3.7
—
—
—
0
0
104
1323
0.68
2.64
4.2
3.5
15.3
15.2
pmol/l
0.15
83
1134
80
1067
0.66
2.57
7.0
6.4
11.9
12.6
umol/l
0.26
75
991
82
1088
0.66
2.56
11.0
8.9
4.7
4.5
e9/l
0.47
69
931
13
288
0.43
2.44
1.6
1.4
—
—
—
0
0
34
547
0.57
2.43
3.3
4.3
0.0
0.0
estimate
0.00
11
165
25
433
0.54
2.32
3.7
4.5
1.0
1.0
kg/l
—
5
64
100
1251
0.70
2.19
7.0
4.1
7.7
6.8
mmol/l
1.36
94
1177
72
955
0.68
2.17
2.0
2.1
91.7
91.9
pmol/l
0.02
40
489
46
665
0.64
2.11
5.6
3.4
7.4
7.4
ph
—
10
128
33
512
0.60
2.04
3.3
2.7
4.9
3.8
e6/l
0.29
25
436
61
826
0.67
2.03
13.0
9.8
0.0
0.0
e9/l
0.65
50
663
8
26
3.13
2.02
4.4
1.6
73.7
59.8
%
—
8
26
67
888
0.69
1.99
8.2
5.5
62.5
59.8
%
1.05
55
809
75
969
0.70
1.92
7.2
5.3
0.2
0.2
e9/l
0.39
61
829
68
884
0.70
1.78
7.6
5.6
8.9
9.0
%
0.12
56
803
34
504
0.63
1.73
8.1
3.6
76.5
81.7
%
0.54
34
496
68
880
0.71
1.73
8.2
5.3
3.0
2.9
%
0.09
58
798
33
489
0.64
1.68
3.8
3.3
2.5
2.5
mmol/l
0.09
27
421
71
908
0.72
1.68
7.2
5.7
23.2
24.7
%
0.61
60
816
67
863
0.71
1.65
7.3
5.3
0.7
0.6
%
0.60
56
780
77
969
0.73
1.64
5.9
4.3
33.1
34.3
g/l
0.99
67
885
37
530
0.66
1.61
3.1
3.0
—
—
—
0
0
90
1103
0.74
1.61
10.5
5.6
1.2
1.2
mmol/l
0.64
72
903
74
934
0.73
1.60
6.9
5.2
0.6
0.6
e9/l
0.29
58
777
52
693
0.70
1.55
4.8
2.6
—
—
—
0
0
75
936
0.74
1.49
6.9
5.2
0.0
0.0
e9/l
0.51
61
788
27
173
1.61
1.46
11.6
6.9
—
—
—
0
0
16
89
1.84
1.40
13.1
9.5
—
—
—
0
0
78
956
0.75
1.35
6.7
5.4
1.6
1.8
e9/l
1.01
65
823
7
150
0.45
1.35
3.3
3.9
—
—
—
0
0
83
1007
0.76
1.33
9.3
5.0
1.2
1.2
mmol/l
0.99
74
880
61
768
0.74
1.27
3.0
3.2
2.3
2.3
mmol/l
0.01
51
645
6
126
0.47
1.19
4.3
4.4
—
—
—
0
0
51
653
0.74
1.18
8.2
5.3
—
—
—
0
0
0
35
0.00
1.16
0.0
1.2
—
2.3
—
0
27
0
35
0.00
1.16
0.0
1.4
—
268.6
—
0
28
56
704
0.75
1.15
5.0
3.9
—
—
—
0
0
7
138
0.50
1.12
1.3
1.5
—
—
—
0
0
32
438
0.70
1.11
3.4
4.0
—
—
—
0
0
8
41
1.98
1.09
5.9
1.6
—
—
—
0
0
5
23
2.19
0.98
1.6
1.4
—
—
—
0
0
0
29
0.00
0.98
0.0
2.7
—
53.7
—
0
21
17
110
1.58
0.92
1.8
2.5
—
—
—
0
0
8
43
1.88
0.88
1.4
1.5
0.3
0.3
g/l
—
8
43
40
507
0.76
0.87
1.7
1.8
400000391.3
14214890.2
pmol/l
0.46
31
401
42
528
0.76
0.86
3.5
2.8
13017.3
10790.2
umol/l
0.06
34
433
11
178
0.60
0.86
5.4
4.0
—
—
—
0
0
8
139
0.56
0.85
1.3
1.4
—
—
—
0
0
15
225
0.65
0.85
1.3
1.3
1.2
19.3
u/ml
—
6
71
8
45
1.80
0.85
1.5
1.5
1.1
1.2
g/l
—
8
45
8
45
1.80
0.85
1.5
2.4
38.9
34.3
umol/l
—
8
36
60
714
0.80
0.79
3.6
3.7
—
—
—
0
0
8
48
1.68
0.79
2.6
3.4
—
—
—
0
0
9
55
1.66
0.74
4.6
2.8
—
—
—
0
0
19
263
0.70
0.73
2.1
4.6
9.7
61.7
ug/l
0.98
14
219
49
590
0.80
0.72
3.5
3.3
68.6
241.5
mg/l
0.73
35
395
53
631
0.81
0.71
2.7
2.0
243.0
354.7
u/l
0.40
48
590
5
93
0.53
0.68
4.8
4.4
—
—
—
0
0
30
234
1.31
0.66
2.6
1.6
—
—
—
0
0
46
381
1.24
0.64
43.7
27.2
2.2
1.5
inr
—
7
43
38
462
0.80
0.62
8.4
6.5
—
—
—
0
0
26
201
1.32
0.61
5.2
3.2
1.4
1.8
mmol/l
0.18
15
145
8
51
1.58
0.61
1.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
59078.1
—
0
15
0
20
0.00
0.60
0.0
3.4
—
49.4
—
0
20
0
22
0.00
0.59
0.0
2.0
—
—
—
0
0
16
116
1.40
0.55
14.1
7.4
23.5
24.8
mmol/l
1.07
16
116
46
388
1.22
0.55
6.8
2.9
3399.1
355.7
ng/l
0.90
39
327
35
287
1.25
0.54
2.2
2.5
1.8
1.7
%
0.09
28
252
51
591
0.84
0.53
3.5
3.2
7.4
7.7
mmol/l
0.12
43
470
67
758
0.85
0.53
3.3
2.3
137.1
180.6
ug/l
1.03
58
669
13
178
0.72
0.50
1.7
1.3
—
—
—
0
0
14
189
0.73
0.50
4.2
3.8
—
—
—
0
0
18
233
0.76
0.49
1.3
1.2
—
—
—
0
0
14
103
1.38
0.46
2.1
2.5
1.4
1.2
%
0.21
14
103
9
131
0.68
0.44
4.4
3.0
—
—
—
0
0
5
32
1.57
0.42
1.2
1.5
—
—
—
0
0
13
172
0.75
0.42
1.9
2.1
13.5
12.5
nmol/l
0.12
13
149
29
241
1.22
0.42
10.6
6.0
0.3
1.3
mmol/l
0.59
19
184
5
33
1.52
0.41
1.4
1.7
—
—
—
0
0
5
33
1.52
0.41
2.8
2.4
4.7
4.8
e9/l
—
5
33
0
15
0.00
0.41
0.0
2.2
—
—
—
0
0
8
59
1.37
0.41
1.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
2.9
—
713.9
—
0
8
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
296.3
—
0
6
0
17
0.00
0.41
0.0
1.6
—
—
—
0
0
5
34
1.48
0.40
2.8
2.6
65.4
62.9
%
—
5
34
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
25
206
1.23
0.39
2.3
2.7
63.4
64.7
e9/l
0.06
18
168
13
170
0.75
0.39
1.7
1.5
—
—
—
0
0
66
728
0.88
0.37
4.9
4.1
—
—
—
0
0
21
173
1.23
0.34
1.2
2.2
—
—
—
0
0
49
547
0.88
0.33
2.1
1.8
1283.7
1183.8
nmol/l
0.30
36
397
15
120
1.26
0.30
1.3
1.3
—
—
—
0
0
27
310
0.86
0.27
3.1
1.9
2.2
2.2
g/l
0.04
22
275
27
235
1.16
0.26
4.6
4.0
—
—
—
0
0
28
245
1.16
0.25
10.8
5.9
4.9
5.1
kpa
0.92
23
231
58
629
0.90
0.25
3.8
4.0
7.2
11.4
mg/mmol
0.64
42
416
28
246
1.15
0.24
10.8
5.9
11.6
11.6
kpa
0.02
23
234
32
287
1.13
0.22
1.7
1.3
2.6
2.7
g/l
0.12
21
155
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
8
103
0.77
0.21
1.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
5
43
1.17
0.21
1.0
2.6
—
16.4
—
0
22
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
16.3
—
—
—
0
0
6
52
1.16
0.19
3.5
4.2
7.8
7.9
kpa
—
6
52
6
52
1.16
0.19
3.5
4.2
4.8
5.2
kpa
—
6
52
8
69
1.16
0.16
1.4
1.3
—
—
—
0
0
10
83
1.21
0.15
1.0
1.3
—
—
—
0
0
23
207
1.12
0.15
1.6
2.3
66.4
65.5
g/l
0.23
18
176
13
112
1.17
0.14
4.9
4.2
—
—
—
0
0
84
874
0.95
0.14
4.5
3.4
264.4
30.5
ng/l
1.32
61
664
12
138
0.86
0.13
1.8
1.3
—
—
—
0
0
31
330
0.93
0.10
1.3
1.2
0.6
0.9
u/ml
—
9
80
27
287
0.94
0.08
3.0
1.9
21.1
23.1
%
0.39
20
246
7
67
1.05
0.08
1.6
1.1
119.3
242.0
u/ml
—
7
61
6
70
0.85
0.07
1.0
1.5
—
—
—
0
0
59
571
1.04
0.07
2.4
2.0
3.4
3.1
mg/l
0.38
43
470
9
88
1.02
0.07
2.6
4.2
—
—
—
0
0
35
366
0.95
0.07
5.9
4.6
—
—
—
0
0
12
132
0.91
0.06
1.8
1.5
—
—
—
0
0
92
940
0.97
0.06
27.1
10.6
1.7
1.4
inr
1.68
26
262
9
101
0.89
0.06
1.2
1.3
—
—
—
0
0
13
141
0.92
0.05
4.8
3.9
—
—
—
0
0
16
149
1.08
0.05
4.6
4.0
—
7.4
—
0
15
32
308
1.04
0.04
2.7
1.9
—
—
—
0
0
24
233
1.03
0.01
1.3
1.4
—
—
—
0
0
40
393
1.02
0.01
1.9
1.6
2.3
1.6
mg/l
0.40
32
308
18
186
0.97
0.00
1.3
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
4.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
3.3
—
—
—
0
0
8
81
0.99
0.00
1.6
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
8
84
0.95
0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
23.2
—
0
7
6
60
1.00
0.00
3.5
4.0
7.4
7.4
ph
—
6
52
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint I9_MI_COMPLICATIONS and mortality.

Females

Parameter HR [95% CI] p-value
I9_MI_COMPLICATIONS 2.357 [1.88, 2.95] < 0.001
Birth year 0.999 [0.99, 1.01] 0.801

During the follow-up period (1.1.1998 — 31.12.2019), 329 out of 499 females with I9_MI_COMPLICATIONS died.

Males

Parameter HR [95% CI] p-value
I9_MI_COMPLICATIONS 2.412 [1.98, 2.93] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 427 out of 704 males with I9_MI_COMPLICATIONS died.

Mortality risk

Mortality risk for people of age

years, who have I9_MI_COMPLICATIONS.

N-year risk Females Males
1 0.256% 0.471%
5 1.612% 2.737%
10 4.016% 6.797%
15 7.708% 13.221%
20 13.262% 21.439%

Relationships between endpoints

Index endpoint: I9_MI_COMPLICATIONS – Complications following myocardial infarction

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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