Mandibular prognathia AND surgery (LeFortI or BSSO or LeFortI AND BSSO), including avohilmo

K11_MN_PROGN_AND_SURGRT_INCLAVO

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 K07.11

1 out of 7 registries used, show all original rules.

223

4. Check minimum number of events

None

223

5. Include endpoints

394

6. Filter based on genotype QC (FinnGen only)

394

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF12

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8708 3947 4747
Only index persons 7257 3299 3958
Unadjusted period prevalence (%)
Whole population 0.12 0.11 0.13
Only index persons 0.14 0.12 0.15
Median age at first event (years)
Whole population 12.20 12.16 12.17
Only index persons 13.34 13.35 13.33

-FinnGen-

Key figures

All Female Male
Number of individuals 394 242 152
Unadjusted period prevalence (%) 0.08 0.08 0.07
Median age at first event (years) 26.48 26.82 25.96

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
331
Matched controls
3308
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K07.11
ICD-10 Finland
Retrognathism (mandibular)(maxillary)
+∞
323.0
331
*
EEC05
NOMESCO Finland
Le Fort I osteotomy
2018.9
140.1
126
*
K07.14
ICD-10 Finland
Retrognaty, maxillary
138.0
125.2
128
15
SBB10
NOMESCO Finland
Teeth copy
17.1
112.6
224
360
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
27.5
108.5
157
105
SJD00
NOMESCO Finland
Removal or reattacment of arrow in fixed orthodontisk device
18.0
94.9
164
171
EDC10
NOMESCO Finland
Sagittal osteotomy of ramus of mandible
110.3
89.9
95
12
SJD10
NOMESCO Finland
Attachment of arrow to fixed orthodontisk device
15.7
84.9
155
176
EB1MA
NOMESCO Finland
Cephalometry with X-ray
15.7
81.0
146
158
SJD20
NOMESCO Finland
Attachment of modifiable arrow of fixed orthodontisk device
17.3
78.7
134
125
SJC10
NOMESCO Finland
Orthodontic bandage in one tooth
15.8
77.1
137
141
SJC50
NOMESCO Finland
Removal of orthodontisk device with at least 7 brackets
14.7
73.0
134
146
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
14.1
71.9
135
154
SJD40
NOMESCO Finland
Fixation of ready made palatinal or lingual arrow
12.0
65.3
133
175
SJD30
NOMESCO Finland
Demanding attachment of arrow to fixed orthodontisk device
17.5
64.6
107
88
SJX10
NOMESCO Finland
Short check-up visit for orthodontisk therapy
9.6
62.3
149
260
SJB00
NOMESCO Finland
Fitting of loose orthodontic device with user information
10.9
60.0
128
180
K07.10
ICD-10 Finland
Asymmetry of jaw
82.0
49.8
55
8
SAA04
NOMESCO Finland
Special inverstigation of mouth
7.9
46.5
121
224
SXC05
NOMESCO Finland
Other oral or dental procedure
7.3
44.6
124
251
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
10.6
44.2
92
116
K07.24
ICD-10 Finland
Open bite
20.6
42.3
64
38
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
11.8
40.3
78
84
K07.1
ICD-10 Finland
Anomalies of jaw-cranial base relationship
151.1
38.6
40
*
SJC00
NOMESCO Finland
Bracket with fixed attachment
110.2
36.6
39
*
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
8.1
36.5
89
143
K07.13
ICD-10 Finland
Retrognaty, mandibular
13.4
35.1
63
57
SJC40
NOMESCO Finland
Removal of orthodontisk device with at most 6 brackets
7.5
34.2
88
152
SJX20
NOMESCO Finland
Check-up visit for orthodontisk therapy
8.0
34.1
83
132
SAA03
NOMESCO Finland
Extended examination of mouth
4.5
33.4
251
1363
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
6.1
31.2
96
209
SJA04
NOMESCO Finland
Very demanding plan for orthodontic care
318.5
29.3
29
*
K07.18
ICD-10 Finland
Another anomaly in the relationship between jaw and skull base
158.4
28.1
29
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
3.7
27.7
218
1137
EFB40
NOMESCO Finland
Removal of internal or external fixation device from facial bones
48.7
26.0
31
7
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
5.8
25.9
80
172
SJX11
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment, restricted
5.3
25.8
88
212
K07.01
ICD-10 Finland
Hyperplasia, hypoplasia mandibular
76.1
25.2
28
*
SJX21
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment
5.6
25.1
80
178
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.4
24.8
179
844
SJB60
NOMESCO Finland
External device grinding and adaptation
6.3
24.4
69
132
SJA03
NOMESCO Finland
Demanding plan for orthodontic care
73.2
24.2
27
*
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
7.0
23.5
61
103
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
7.0
21.8
56
93
K07.21
ICD-10 Finland
Anomalies of dental arch relationship
26.3
21.2
29
12
K07.60
ICD-10 Finland
Snapping jaw
6.5
20.2
55
99
K07.03
ICD-10 Finland
Micrognatia (hypoplasia) of the upper jaw
55.8
18.2
21
*
SJA01
NOMESCO Finland
Estimation of need for orthodontic care
44.7
17.5
21
5
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
5.0
17.0
58
136
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
7.9
16.1
37
52
K07.12
ICD-10 Finland
Prognathism (mandibular)(maxillary)
63.2
15.9
18
*
K07.19
ICD-10 Finland
Anomalies in the relationship between jaw and skull base UNS
89.4
15.7
17
*
SAC03
NOMESCO Finland
Separate planning of oral and dental treatment, very demanding
11.7
15.3
28
26
K07.30
ICD-10 Finland
Spacing, abnormal of tooth or teeth
4.0
15.3
65
189
EBB10
NOMESCO Finland
Insertion of dental implant
15.1
14.8
24
17
SAC02
NOMESCO Finland
Separate planning of oral and dental treatment, demanding
5.1
13.7
44
96
SJA02
NOMESCO Finland
Plan for orthodontic care
52.2
12.9
15
*
K00.00
ICD-10 Finland
Hypodontia
6.5
11.3
29
48
SXC03
NOMESCO Finland
Other oral or dental procedure
12.5
11.0
19
16
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
12.6
10.5
18
15
EB1WA
NOMESCO Finland
NA
16.7
10.5
16
10
SJX00
NOMESCO Finland
Reparation of orthodontiskt device by dentist
8.9
10.2
21
25
SJB10
NOMESCO Finland
Fitting of loose orthodontic device with user information, demanding
4.7
9.0
30
69
SAC01
NOMESCO Finland
Separate planning of oral and dental treatment, standard
3.4
8.9
43
138
SAA02
NOMESCO Finland
Basic examination of mouth
2.4
8.9
277
2258
SJD50
NOMESCO Finland
Production and attachment of palatinal or lingual arrow
7.3
8.7
20
29
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
12.0
8.7
15
13
K07.69
ICD-10 Finland
Dislocation of the jaw joint UNS
8.9
8.4
17
20
ZXA10
NOMESCO Finland
Bilateral
2.6
8.0
62
270
K07.4
ICD-10 Finland
Malocclusion, unspecified
6.9
8.0
19
29
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
6.0
7.7
20
35
OIKK
NOMESCO Finland
NA
2.8
7.6
50
197
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
7.4
7.6
17
24
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
2.8
7.6
50
198
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
4.3
7.2
25
61
K01.0
ICD-10 Finland
Embedded teeth
4.9
7.2
22
47
EBA10
NOMESCO Finland
Surgical removal of tooth
2.3
7.0
68
332
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
7.0
102
595
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prothetic work
5.0
7.0
21
44
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
3.3
6.9
33
106
SJF01
NOMESCO Finland
Assessment of need for orthodontic treatment
2.7
6.6
45
181
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
12.6
6.6
11
9
SJE90
NOMESCO Finland
Finishing face of orthodontick therapy
7.6
6.5
14
19
EEC02
NOMESCO Finland
Rapid expansion of maxilla
+∞
6.3
6
*
K01.17
ICD-10 Finland
Retained molar with obstruction in the lower jaw
4.1
6.1
22
56
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.3
6.0
57
273

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
25
137
1.88
2.19
2.0
2.9
56.1
99.7
ng/l
1.21
20
124
172
1449
1.33
2.08
3.0
3.4
0.0
0.0
estimate
0.00
24
286
170
1435
1.32
2.01
4.4
4.7
0.0
0.0
estimate
0.00
25
296
170
1436
1.32
1.99
3.0
3.3
0.0
0.0
estimate
0.00
24
286
7
23
3.08
1.80
1.6
1.7
—
—
—
0
0
322
3007
1.39
1.74
8.8
11.8
3.9
3.9
mmol/l
0.44
313
2908
311
2889
1.36
1.73
11.4
13.6
13.2
13.3
%
0.46
301
2842
321
3003
1.37
1.66
8.8
11.8
139.6
139.7
mmol/l
0.11
315
2914
7
25
2.83
1.65
6.3
5.6
0.7
1.6
ug/l
—
7
25
8
32
2.53
1.60
1.0
1.0
—
—
—
0
0
57
421
1.41
1.56
1.7
1.6
432.8
18011216.4
pmol/l
0.50
47
372
23
138
1.71
1.55
1.1
1.2
0.4
2.4
u/ml
1.44
12
71
261
2385
1.28
1.51
5.0
4.3
38.0
38.2
mmol/mol
0.17
247
2262
20
118
1.73
1.44
1.2
1.1
8.8
2.7
u/ml
—
5
24
200
1782
1.25
1.39
2.7
2.9
—
—
—
0
0
24
151
1.63
1.38
2.5
2.2
—
—
—
0
0
146
1257
1.26
1.37
3.6
8.4
1.2
1.2
mmol/l
2.71
124
1105
100
822
1.29
1.37
2.9
3.0
—
—
—
0
0
0
37
0.00
1.35
0.0
7.9
—
98.6
—
0
31
20
121
1.69
1.33
1.0
1.2
4.2
0.6
u/ml
0.44
13
77
180
1592
1.24
1.32
3.2
5.4
6.3
6.4
mmol/l
0.14
163
1433
9
176
0.50
1.32
1.9
3.1
—
—
—
0
0
265
2448
1.25
1.29
4.2
3.8
14.4
14.5
pmol/l
0.45
243
2254
303
2846
1.28
1.26
4.6
4.3
1.8
2.2
mu/l
0.51
278
2667
85
691
1.29
1.26
3.0
3.1
1.0
1.0
kg/l
1.26
12
96
20
124
1.65
1.23
1.1
1.2
13.9
9.1
u/ml
0.39
14
88
223
2030
1.23
1.21
3.7
4.1
—
—
—
0
0
123
1056
1.24
1.16
2.6
2.3
—
—
—
0
0
280
2622
1.23
1.11
3.6
3.3
5.6
5.7
mmol/l
0.50
263
2428
82
677
1.27
1.08
1.5
1.6
—
—
—
0
0
11
189
0.57
1.03
1.6
1.4
—
—
—
0
0
5
110
0.45
1.01
1.0
1.1
—
—
—
0
0
5
110
0.45
1.01
1.0
1.8
—
—
—
0
0
23
156
1.50
1.01
1.4
1.2
—
—
—
0
0
21
306
0.67
1.00
4.4
11.2
24.6
25.0
mmol/l
0.47
21
306
234
2165
1.20
0.99
3.4
3.9
7.8
8.9
mm/h
1.32
224
2007
38
287
1.36
0.96
1.5
1.4
—
—
—
0
0
0
32
0.00
0.95
0.0
31.1
—
6.7
—
0
26
8
144
0.55
0.95
2.1
2.5
64.5
66.6
g/l
—
8
134
43
333
1.33
0.93
1.4
1.5
1216.5
1144.5
nmol/l
0.24
36
264
131
1156
1.20
0.93
3.2
3.0
—
—
—
0
0
44
342
1.32
0.93
2.0
1.9
—
—
—
0
0
39
299
1.34
0.90
1.2
1.6
—
—
—
0
0
41
318
1.32
0.88
1.3
1.3
—
—
—
0
0
98
847
1.21
0.86
6.3
5.5
1.1
1.1
inr
0.04
41
271
6
34
1.78
0.76
1.3
1.2
—
—
—
0
0
12
75
1.62
0.75
3.8
2.9
78.2
18.7
mu/l
0.46
12
70
8
132
0.60
0.75
1.5
1.6
1.1
1.2
g/l
—
8
124
146
1329
1.16
0.69
3.8
4.1
—
—
—
0
0
10
61
1.66
0.69
1.3
1.0
—
—
—
0
0
25
189
1.34
0.66
1.0
1.2
—
—
—
0
0
8
130
0.61
0.65
1.5
1.6
0.2
0.2
g/l
—
8
124
5
29
1.73
0.64
1.0
1.2
—
—
—
0
0
24
182
1.34
0.63
1.8
1.4
—
—
—
0
0
328
3179
1.19
0.61
10.7
12.0
40.5
40.4
%
0.07
263
2644
5
30
1.67
0.61
1.0
1.0
—
—
—
0
0
331
3211
1.19
0.61
9.3
10.7
22.4
20.8
mg/l
0.39
254
2346
8
51
1.58
0.60
1.4
5.1
—
—
—
0
0
0
20
0.00
0.60
0.0
2.5
—
—
—
0
0
0
20
0.00
0.60
0.0
5.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
216.5
—
0
20
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
36
292
1.26
0.59
1.3
1.2
—
—
—
0
0
284
2727
1.15
0.58
3.8
3.8
2.7
2.8
mmol/l
0.66
270
2555
80
705
1.17
0.58
2.4
2.2
2.5
2.8
mg/l
0.50
73
611
18
240
0.74
0.57
3.8
7.0
—
—
—
0
0
6
36
1.68
0.57
1.8
3.2
4.2
2.3
mmol/l
—
6
36
5
88
0.56
0.56
1.0
1.5
—
60.0
—
0
9
5
89
0.56
0.56
1.0
1.5
—
—
—
0
0
47
396
1.21
0.56
1.1
1.2
—
—
—
0
0
143
1319
1.13
0.55
4.2
6.8
13.2
11.1
umol/l
0.64
137
1240
28
348
0.79
0.54
1.8
2.1
—
—
—
0
0
221
2094
1.13
0.54
4.7
6.6
77.4
85.4
u/l
1.64
213
1973
153
1644
0.89
0.54
5.0
6.8
0.0
0.0
e9/l
0.20
132
1422
11
74
1.50
0.54
2.9
11.1
1.5
1.6
%
0.17
11
67
153
1643
0.89
0.53
5.0
6.8
0.5
0.5
e9/l
0.72
132
1421
282
2714
1.14
0.53
3.5
3.6
4.6
4.7
mmol/l
0.57
268
2566
86
768
1.15
0.53
2.3
2.8
57.5
29.7
ng/l
0.31
39
396
32
260
1.25
0.53
2.5
2.5
27.3
216.0
u/l
0.52
27
221
65
740
0.85
0.53
4.0
4.9
—
—
—
0
0
11
75
1.48
0.51
2.9
10.9
0.9
0.9
%
0.02
11
69
34
280
1.23
0.51
1.3
1.3
—
—
—
0
0
12
84
1.44
0.50
1.2
1.1
2.4
6.6
u/ml
—
7
30
69
777
0.86
0.49
3.0
3.5
—
—
—
0
0
7
45
1.57
0.49
1.1
1.2
—
—
—
0
0
58
506
1.17
0.48
1.3
1.4
20.6
20.0
nmol/l
0.11
51
438
11
76
1.46
0.48
1.5
1.3
211.2
311.8
ug/g
—
6
37
7
46
1.53
0.48
3.0
15.1
11.0
11.1
mmol/l
—
7
40
7
46
1.53
0.48
3.0
15.1
106.1
105.3
mmol/l
—
7
40
17
128
1.34
0.48
1.0
1.2
—
—
—
0
0
20
254
0.78
0.47
2.2
2.6
0.6
0.7
ug/l
—
8
141
7
49
1.44
0.46
6.4
3.3
—
—
—
0
0
279
2694
1.12
0.46
3.5
3.5
1.5
1.5
mmol/l
0.19
265
2533
9
129
0.69
0.44
1.1
1.1
—
—
—
0
0
14
104
1.36
0.43
5.2
2.7
—
—
—
0
0
73
809
0.88
0.42
1.7
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
1.1
—
0
16
0
17
0.00
0.40
0.0
1.5
—
1.9
—
0
17
0
17
0.00
0.40
0.0
1.0
—
1369.1
—
0
17
57
505
1.15
0.40
1.2
1.2
13.3
7.7
u/ml
0.20
23
194
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
0
19
0.00
0.39
0.0
2.5
—
—
—
0
0
142
1507
0.91
0.38
7.8
8.9
0.0
0.0
e9/l
0.53
112
1192
8
114
0.70
0.37
1.5
6.1
0.9
1.5
%
—
8
114
52
583
0.88
0.36
3.1
3.1
—
—
—
0
0
94
867
1.11
0.36
1.8
2.5
—
—
—
0
0
65
587
1.13
0.36
4.0
4.2
2.5
12.9
mg/mmol
3.56
40
393
63
568
1.13
0.35
3.1
3.5
1289.3
203.2
mg/l
0.40
39
387
26
308
0.83
0.35
3.2
12.2
—
—
—
0
0
113
1055
1.10
0.35
1.6
1.5
1.2
2.5
u/ml
0.98
23
240
22
182
1.22
0.34
1.5
1.2
—
—
—
0
0
17
208
0.81
0.32
1.1
1.2
—
27.5
—
0
10
7
52
1.35
0.31
1.1
1.2
—
—
—
0
0
78
844
0.91
0.31
3.1
3.6
37.2
116.3
e6/l
0.50
60
640
163
1705
0.92
0.30
4.8
6.7
2.0
2.1
e9/l
0.41
144
1508
11
84
1.32
0.30
1.3
3.1
—
—
—
0
0
93
868
1.09
0.29
1.6
1.7
102.2
98.5
pmol/l
0.32
51
434
7
57
1.23
0.29
1.6
1.9
—
—
—
0
0
158
1509
1.08
0.29
3.1
2.9
66.7
78.0
ug/l
0.69
148
1411
149
1561
0.93
0.28
5.4
6.9
3.2
2.9
%
0.58
141
1479
150
1571
0.93
0.28
5.6
7.2
8.3
8.3
%
0.05
143
1496
38
426
0.88
0.28
1.5
1.5
426.7
500.7
titre
—
6
81
14
172
0.81
0.28
1.3
1.4
198.7
299.4
miu/ml
—
7
86
8
64
1.26
0.27
1.1
1.7
—
—
—
0
0
17
142
1.21
0.25
1.9
6.8
0.2
0.3
g/l
—
9
90
76
709
1.09
0.24
1.7
1.7
1.5
1.3
mmol/l
0.77
65
639
106
1005
1.07
0.23
4.2
6.0
37.9
37.4
g/l
0.51
94
956
95
1003
0.93
0.22
3.4
4.2
25.6
48.7
e6/l
0.92
65
674
65
697
0.92
0.22
2.8
3.7
7.4
7.4
ph
0.24
11
123
163
1689
0.94
0.22
5.0
7.3
0.2
0.2
e9/l
0.61
146
1495
47
431
1.10
0.22
2.6
3.3
73.2
716.3
ng/l
1.66
32
265
0
11
0.00
0.21
0.0
1.0
—
18.4
—
0
5
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
264
2585
1.06
0.21
3.1
3.3
1.2
1.2
mmol/l
0.25
249
2431
0
12
0.00
0.21
0.0
3.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
236.9
—
0
7
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
22
192
1.15
0.21
1.2
2.7
4.3
4.0
e9/l
0.24
22
176
0
13
0.00
0.21
0.0
6.8
—
—
—
0
0
0
13
0.00
0.21
0.0
7.5
—
—
—
0
0
0
13
0.00
0.21
0.0
2.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
2.6
—
1.2
—
0
14
0
14
0.00
0.20
0.0
5.2
—
280.0
—
0
6
40
436
0.91
0.19
2.2
9.0
1.1
1.2
mmol/l
0.13
34
411
99
1037
0.94
0.19
1.7
1.6
—
—
—
0
0
89
935
0.94
0.18
1.8
1.5
1.7
2.0
g/l
0.56
54
537
38
349
1.10
0.18
1.8
1.7
—
—
—
0
0
12
142
0.84
0.17
1.3
1.4
—
—
—
0
0
12
142
0.84
0.17
1.3
1.4
—
—
—
0
0
21
186
1.14
0.17
2.8
3.4
84.5
70.9
e9/l
0.25
15
131
25
277
0.90
0.16
2.4
2.4
21511.4
4499.9
u/l
—
8
105
8
71
1.13
0.16
1.4
1.8
—
—
—
0
0
8
72
1.11
0.16
1.0
1.2
—
—
—
0
0
6
78
0.77
0.15
1.0
1.2
—
—
—
0
0
147
1512
0.96
0.14
5.5
7.1
0.7
0.7
%
0.36
138
1436
7
90
0.77
0.14
1.0
2.7
437.9
446.8
mg/l
—
7
85
63
598
1.06
0.14
2.0
3.1
321.9
6281.1
umol/l
2.42
58
526
369
3666
1.10
0.14
13.6
15.7
259.4
259.7
e9/l
0.03
361
3562
33
356
0.92
0.14
2.7
2.5
2.4
2.4
mmol/l
0.51
28
304
14
122
1.15
0.14
2.7
10.7
25.1
24.6
mmol/l
0.22
14
111
8
98
0.81
0.14
1.0
1.3
—
—
—
0
0
8
100
0.80
0.13
2.8
4.1
3.7
10.8
umol/l
—
8
75
73
763
0.95
0.13
3.1
2.4
—
—
—
0
0
108
1116
0.96
0.13
4.9
6.7
—
—
—
0
0
56
532
1.06
0.12
1.4
1.6
—
—
—
0
0
11
127
0.86
0.12
4.7
14.3
—
—
—
0
0
160
1637
0.96
0.12
5.3
6.9
32.9
31.3
%
1.19
151
1562
70
671
1.05
0.12
2.5
3.2
—
—
—
0
0
41
387
1.07
0.11
1.3
1.3
—
—
—
0
0
21
228
0.92
0.10
4.6
5.3
0.0
0.8
%
—
6
70
105
1021
1.04
0.10
2.0
1.8
—
—
—
0
0
54
564
0.95
0.10
4.0
4.3
—
—
—
0
0
339
3366
1.05
0.10
9.2
9.2
—
—
—
0
0
87
843
1.04
0.10
3.4
3.7
8.3
8.6
mmol/l
0.20
77
747
5
46
1.09
0.09
1.0
1.8
—
—
—
0
0
5
46
1.09
0.09
1.0
1.8
—
—
—
0
0
5
46
1.09
0.09
1.0
1.8
—
—
—
0
0
5
46
1.09
0.09
1.0
1.8
—
—
—
0
0
13
145
0.89
0.09
1.5
1.4
—
—
—
0
0
369
3672
1.08
0.09
13.6
15.7
4.6
4.6
e12/l
1.19
359
3561
74
765
0.96
0.09
3.2
3.6
0.5
0.3
e6/l
0.21
57
569
31
329
0.94
0.09
3.0
1.8
—
—
—
0
0
26
243
1.07
0.09
1.2
1.3
—
—
—
0
0
15
165
0.91
0.09
5.1
2.1
—
—
—
0
0
6
54
1.11
0.09
2.5
1.7
—
—
—
0
0
29
308
0.94
0.08
3.1
1.9
—
—
—
0
0
16
175
0.91
0.08
1.0
1.1
—
—
—
0
0
28
263
1.07
0.08
3.7
3.8
—
—
—
0
0
6
57
1.05
0.08
1.0
1.1
—
—
—
0
0
369
3673
1.07
0.08
13.6
15.7
6.7
6.6
e9/l
0.07
358
3558
5
61
0.82
0.08
2.4
2.7
—
—
—
0
0
78
757
1.04
0.08
2.8
3.5
0.0
0.0
estimate
0.50
24
289
13
117
1.11
0.08
2.2
2.2
—
—
—
0
0
31
327
0.94
0.08
3.2
1.8
—
—
—
0
0
31
327
0.94
0.08
3.2
1.8
—
—
—
0
0
6
70
0.85
0.07
1.3
1.4
—
—
—
0
0
22
235
0.93
0.07
3.3
11.0
1.6
0.7
mmol/l
0.66
16
186
12
108
1.11
0.07
2.0
1.6
—
—
—
0
0
31
326
0.95
0.07
3.0
1.8
—
—
—
0
0
9
84
1.07
0.07
7.9
7.2
—
—
—
0
0
19
177
1.08
0.06
1.7
1.5
—
—
—
0
0
13
142
0.91
0.06
2.1
2.3
14.8
32.3
u/ml
1.77
13
135
33
315
1.05
0.06
1.9
2.9
23.5
24.6
%
0.18
26
280
13
119
1.10
0.06
2.3
8.2
—
—
—
0
0
66
643
1.03
0.05
2.1
1.7
—
—
—
0
0
21
198
1.06
0.05
1.4
3.9
—
—
—
0
0
32
333
0.96
0.05
1.4
1.5
—
—
—
0
0
18
191
0.94
0.04
2.3
11.3
126.7
123.8
g/l
0.29
18
182
20
211
0.95
0.04
4.8
5.5
0.0
0.1
%
—
5
61
25
261
0.95
0.04
3.5
1.9
—
—
—
0
0
159
1606
0.98
0.04
5.1
6.7
52.8
54.2
%
0.88
152
1531
82
834
0.98
0.04
4.2
7.7
—
—
—
0
0
55
538
1.03
0.03
2.4
3.0
556.5
581.7
mosm/kgh2o
0.32
48
463
13
122
1.07
0.02
1.4
1.6
—
—
—
0
0
117
1159
1.01
0.02
3.4
8.3
1.2
1.2
mmol/l
1.86
104
1075
27
278
0.97
0.02
1.3
1.3
101.0
144.9
iu/ml
0.35
11
113
186
1850
1.01
0.02
6.3
9.5
3.7
3.8
e9/l
0.32
164
1596
23
237
0.97
0.01
4.4
2.3
—
—
—
0
0
27
267
1.01
0.00
1.3
1.6
—
—
—
0
0
55
547
1.01
0.00
3.2
2.6
196.1
93.6
ug/g
1.13
47
425
82
825
0.99
0.00
2.2
3.0
2.4
2.4
mmol/l
0.91
75
739
102
1016
1.01
0.00
2.4
2.0
—
—
—
0
0
51
514
0.99
0.00
1.2
1.3
17.1
27.1
iu/ml
0.74
21
145
61
614
0.99
0.00
1.5
2.5
0.6
1.1
mg/l
1.67
45
448
7
73
0.96
0.00
4.4
2.7
959.4
1883.1
u/ml
—
7
63
0
7
0.00
0.00
0.0
3.0
—
33.0
—
0
7
9
92
0.98
0.00
2.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
8
86
0.93
0.00
1.0
1.1
—
—
—
0
0
5
57
0.88
0.00
1.2
1.1
—
—
—
0
0
8
86
0.93
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
17.4
—
0.5
—
0
8
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
10.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
8
80
1.00
0.00
2.3
1.3
—
—
—
0
0
9
96
0.94
0.00
1.2
1.2
—
—
—
0
0
7
74
0.94
0.00
1.0
3.1
—
—
—
0
0
5
54
0.92
0.00
1.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
9.3
—
25.6
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
18.8
—
0
9
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
5
57
0.88
0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
9
93
0.97
0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint K11_MN_PROGN_AND_SURGRT_INCLAVO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have K11_MN_PROGN_AND_SURGRT_INCLAVO.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: K11_MN_PROGN_AND_SURGRT_INCLAVO – Mandibular prognathia AND surgery (LeFortI or BSSO or LeFortI AND BSSO), including avohilmo

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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