No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
619 |
4. Check minimum number of eventsNone |
619 |
5. Include endpointsNone |
619 |
6. Filter based on genotype QC (FinnGen only) |
572 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF10
Mandibular prognathia
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10540 | 4767 | 5746 |
| Only index persons | 9023 | 4093 | 4930 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.14 | 0.16 |
| Only index persons | 0.17 | 0.15 | 0.19 |
| Median age at first event (years) | |||
| Whole population | 13.23 | 13.24 | 13.15 |
| Only index persons | 14.49 | 14.49 | 14.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 572 | 336 | 236 |
| Unadjusted period prevalence (%) | 0.11 | 0.12 | 0.11 |
| Median age at first event (years) | 32.17 | 30.43 | 34.64 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 619
- Matched controls
- 6190
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
31.7
307.7
278
155
K07.11
ICD-10 Finland
Retrognathism (mandibular)(maxillary)
+∞
307.7
619
*
K07.14
ICD-10 Finland
Retrognaty, maxillary
277.9
307.7
217
12
SBB10
NOMESCO Finland
Dental impressions
14.2
257.5
383
633
EB1MA
NOMESCO Finland
Cephalometry with X-ray
15.6
228.7
243
246
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
15.8
219.6
227
219
SJD00
NOMESCO Finland
Removal and/or reactivation of orthodontic arch wire
13.4
202.8
238
276
SJD20
NOMESCO Finland
Placement of modified orthodontic arch wire
14.7
185.9
194
187
SJD10
NOMESCO Finland
Placement of orthodontic arch wire
12.0
180.8
227
286
SJC50
NOMESCO Finland
Removal of fixed orthodontic appliance with at least 7 brackets
11.9
164.9
201
241
EEC05
NOMESCO Finland
Le Fort I osteotomy
975.0
158.9
149
*
SJC10
NOMESCO Finland
Orthodontic band in one tooth
11.3
151.7
189
232
SJD30
NOMESCO Finland
Demanding placement of orthodontic arch wire
14.9
143.3
140
119
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
13.4
135.3
142
135
K07.24
ICD-10 Finland
Open bite
20.7
133.9
107
62
SJD40
NOMESCO Finland
Placement of prefabricated palatal or lingual arch
9.0
127.8
192
294
SJX10
NOMESCO Finland
Orthodontic treatment/control appointment, short
8.0
126.7
222
404
SAA04
NOMESCO Finland
Special examination of mouth
8.5
126.4
202
332
SJB00
NOMESCO Finland
Fitting of removable appliance incl. patient instructions
8.3
113.8
180
290
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
9.0
100.0
141
197
EDC10
NOMESCO Finland
Sagittal osteotomy of ramus of mandible
136.9
98.4
103
9
K07.13
ICD-10 Finland
Retrognaty, mandibular
14.7
95.1
90
71
K07.10
ICD-10 Finland
Asymmetry of jaw
119.6
78.1
83
8
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
6.9
76.6
136
242
K07.21
ICD-10 Finland
Anomalies of dental arch relationship
31.9
76.0
50
17
SXC05
NOMESCO Finland
Other oral or dental procedure
5.1
72.4
197
518
SAA03
NOMESCO Finland
Extended examination of mouth
4.5
63.8
457
2383
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
5.9
59.8
123
250
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
4.7
58.2
166
446
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
7.2
56.3
91
145
SJX20
NOMESCO Finland
Orthodontic treatment/control appointment
5.9
55.8
112
222
K07.1
ICD-10 Finland
Anomalies of jaw-cranial base relationship
150.6
52.7
55
*
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
5.1
52.0
125
290
SJB60
NOMESCO Finland
Adjustment and grinding of removable appliance
5.9
51.9
104
205
SJC00
NOMESCO Finland
Bondable bracket or other fixed attachement
100.5
50.7
55
6
SJC40
NOMESCO Finland
Removal of fixed orthodontic appliance with at most 6 brackets
5.0
49.1
123
295
K07.60
ICD-10 Finland
Snapping jaw
5.8
47.8
97
193
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
5.0
46.7
114
267
WZC00
NOMESCO Finland
Treatment plan or consultation
3.3
46.3
349
1750
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
3.4
45.8
398
2164
EBB10
NOMESCO Finland
Insertion of dental implant
17.5
45.6
38
23
SJX21
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment
5.1
45.5
109
251
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
6.9
42.4
69
110
SJA04
NOMESCO Finland
Very demanding workplan for orthodontic treatment
118.2
41.3
44
*
K07.01
ICD-10 Finland
Hyperplasia, hypoplasia mandibular
115.3
40.3
43
*
SJX11
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment, restricted
4.1
37.8
122
352
SAC03
NOMESCO Finland
Separate planning of oral and dental treatment, very demanding
11.9
35.6
37
33
SJA03
NOMESCO Finland
Demanding workplan for orthodontic treatment
54.7
34.9
41
8
K07.18
ICD-10 Finland
Another anomaly in the relationship between jaw and skull base
98.3
34.1
37
*
SJA01
NOMESCO Finland
Assesment of orthodontic treatment need
42.7
32.5
40
10
EFB40
NOMESCO Finland
Removal of internal or external fixation device from facial bones
38.8
31.9
40
11
K07.30
ICD-10 Finland
Spacing, abnormal of tooth or teeth
3.6
27.6
101
315
K07.12
ICD-10 Finland
Prognathism (mandibular)(maxillary)
65.1
27.2
31
5
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
8.7
26.4
34
41
K07.03
ICD-10 Finland
Micrognatia (hypoplasia) of the upper jaw
75.7
26.0
29
*
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
6.8
25.5
41
64
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
9.8
24.6
29
31
K00.00
ICD-10 Finland
Hypodontia
6.0
24.1
44
78
SAC02
NOMESCO Finland
Separate planning of oral and dental treatment, demanding
4.4
23.1
62
154
SJD50
NOMESCO Finland
Placement of prefabricated palatal or lingual arch, dentist-made
7.4
22.2
33
47
SHA04
NOMESCO Finland
Stomatognathic treatment, very demanding
9.4
22.2
27
30
K07.19
ICD-10 Finland
Anomalies in the relationship between jaw and skull base UNS
79.6
20.8
23
*
SJX00
NOMESCO Finland
Reparation of orthodontic appliance by dentist
7.0
20.1
31
46
K07.69
ICD-10 Finland
Dislocation of the jaw joint UNS
7.3
20.1
30
43
K07.4
ICD-10 Finland
Malocclusion, unspecified
5.3
18.6
38
75
EB1WA, ,
NOMESCO Finland
18.0
17.1
26
15
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
12.1
16.2
29
25
SXC03
NOMESCO Finland
Other oral or dental procedure
16.2
15.8
25
16
EBB15
NOMESCO Finland
Insertion of dental implant abutment
19.8
15.7
23
12
ZXE20
NOMESCO Finland
More than three and less than five hours
2.6
15.0
97
413
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
5.7
14.9
28
51
SJA02
NOMESCO Finland
Workplan for orthodontic treatment
32.6
14.9
19
6
SAA02
NOMESCO Finland
Basic examination of mouth
2.3
14.4
514
4186
Z3229
NOMESCO Finland
Other healthcare associate professional
2.8
14.2
74
282
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.6
14.0
47
137
SJB10
NOMESCO Finland
Fitting of removable appliance incl. patient instructions, demanding
3.7
13.9
45
128
SXB00
NOMESCO Finland
Removal of sutures from oral mucosa
3.2
13.9
59
200
OIKK, ,
NOMESCO Finland
2.8
13.5
74
289
WZA90
NOMESCO Finland
Other medical or dental certificate
2.0
13.4
198
1181
SPC20
NOMESCO Finland
Implant borne crown
21.7
13.4
19
9
SAC01
NOMESCO Finland
Separate planning of oral and dental treatment, standard
3.1
12.8
56
193
SPB10
NOMESCO Finland
Manufacture of a temporary crown to tooth at the dental office
15.8
12.7
20
13
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
19.4
11.6
17
9
SAA01
NOMESCO Finland
Simple examination of mouth
2.1
11.6
498
4120
QA1S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head
15.4
11.4
18
12
SPC10
NOMESCO Finland
Standard dental crown
9.9
11.3
22
23
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
11.0
172
1036
SJF01
NOMESCO Finland
Assessment of need for orthodontic treatment
2.7
11.0
64
258
SPA20
NOMESCO Finland
Selection and insertion of implant abutment
28.6
10.8
14
5
SPF00
NOMESCO Finland
Reparation of dental prosthesis without impressions
8.4
10.4
22
27
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
2.2
9.8
86
418
EBA00
NOMESCO Finland
Extraction of tooth
1.7
9.7
269
1909
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.1
9.4
98
509
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
12.6
9.4
16
13
G50.1
ICD-10 Finland
Atypical facial pain
7.1
9.4
22
32
WX110
NOMESCO Finland
Infiltration anesthesia
1.8
9.3
472
3938
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
3.5
9.2
31
91
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.8
9.1
28
77
SDA02
NOMESCO Finland
Periodontal treatment, brief
1.7
9.0
249
1757
SDA03
NOMESCO Finland
Periodontal treatment
1.7
8.8
250
1776
SJB30
NOMESCO Finland
Extraoral traction arrangements and operation instruction, removable appliance
3.7
8.6
27
75
SJE90
NOMESCO Finland
Orthodontic finishing
8.4
8.6
18
22
EB1S1
NOMESCO Finland
Photography of teeth
8.4
8.6
18
22
K07.26
ICD-10 Finland
Anomalies of dental arch relationship
16.6
8.6
13
8
SFA10
NOMESCO Finland
One-surface restoration
1.7
8.4
374
2968
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.7
8.4
201
1360
EDC30
NOMESCO Finland
Genioplasty
+∞
8.3
8
*
SPAT1301
SPAT
No procedures
1.7
8.2
194
1307
K01.0
ICD-10 Finland
Embedded teeth
3.3
8.2
30
93
EEC02
NOMESCO Finland
Rapid expansion of maxilla
33.8
8.1
10
*
SPC40
NOMESCO Finland
Preparation of first or second intermediate attachment tooth for bridge
22.4
8.0
11
5
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
1.7
7.6
151
966
K05.30
ICD-10 Finland
Periodontitis complex
2.1
7.5
74
376
ZXX07
NOMESCO Finland
Extent of procedure, 7 units
81.0
7.4
8
*
SPA02
NOMESCO Finland
Preparation for dental prosthetics
3.6
7.3
24
69
SPA51
NOMESCO Finland
Determination of bite and dental arch location, demanding
11.0
7.3
13
12
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
3.9
7.3
21
55
K07.29
ICD-10 Finland
Anomaly in the relationship between the tooth arches UNS
+∞
7.3
7
*
EBA10
NOMESCO Finland
Operative extraction of tooth
1.8
7.2
126
775
Z97.2
ICD-10 Finland
Presence of dental prosthetic device (complete)(partial)
4.6
7.2
17
38
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.7
7.2
38
146
WX720
NOMESCO Finland
Own respiration
3.0
7.2
32
112
SPB20
NOMESCO Finland
Temporary bridge
20.3
7.1
10
5
K07.04
ICD-10 Finland
Macrognathism (mandibular)(maxillary)
20.3
7.1
10
5
SDA01
NOMESCO Finland
Periodontal treatment, very brief
1.6
7.0
228
1654
ZXA10
NOMESCO Finland
Bilateral
1.8
6.9
103
604
K00.09
ICD-10 Finland
Lack of teeth due to lack of dental development UNS
7.3
6.7
15
21
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
6.7
89
503
K07.23
ICD-10 Finland
Deep bite
2.3
6.7
53
247
EB1VA, ,
NOMESCO Finland
2.0
6.6
73
386
J01CE02
ATC
phenoxymethylpenicillin; oral
1.6
6.6
416
3487
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.5
6.6
323
2559
SDA04
NOMESCO Finland
Demanding periodontal treatment
1.6
6.5
167
1140
SPA10
NOMESCO Finland
Setting attachments on tooth or implanted bracket or imblant based structures
+∞
6.3
6
*
EMAK, ,
NOMESCO Finland
2.8
6.1
30
111
F45.8
ICD-10 Finland
Other somatoform disorders
2.1
6.1
55
270
SPA47
NOMESCO Finland
Precision impression for denture
3.9
6.0
17
44
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
53
240
2.32
7.11
3.0
3.1
128.94
143.79
ng/l
0.11
47
219
18
63
2.91
4.09
1.9
1.7
13.16
13.11
%
0.07
18
63
252
2046
1.39
3.83
7.7
7.7
1.23
1.22
mmol/l
1.85
221
1804
306
2585
1.36
3.56
4.7
4.9
6.47
6.44
mmol/l
0.11
283
2354
106
746
1.51
3.45
1.7
1.6
415.68
28354100.65
pmol/l
1.06
90
656
278
2353
1.33
3.04
3.6
3.3
0.00
0.01
estimate
0.50
39
463
275
2325
1.33
3.03
3.6
3.2
0.00
0.00
estimate
0.50
42
489
167
1309
1.38
3.02
2.4
2.6
56.24
59.56
u/l
0.38
156
1228
491
4525
1.41
3.02
4.9
4.4
1.82
2.11
mu/l
0.56
457
4215
275
2326
1.33
3.02
5.0
4.5
0.00
0.00
estimate
-0.00
41
479
426
3847
1.34
2.91
4.3
3.8
14.44
14.50
pmol/l
0.24
393
3529
114
847
1.42
2.81
1.4
1.4
18.69
20.82
nmol/l
0.95
98
732
498
4623
1.40
2.74
14.4
13.8
13.97
14.13
%
0.37
489
4545
381
3404
1.31
2.70
6.0
6.8
80.91
83.45
u/l
0.28
366
3216
140
1086
1.37
2.68
3.7
3.1
1.02
1.02
kg/l
1.01
19
138
69
475
1.51
2.51
2.4
2.2
412.64
361.66
nmol/l
0.45
64
442
36
212
1.74
2.45
2.2
1.6
—
—
—
0
0
143
1129
1.35
2.44
2.5
2.3
2.52
2.80
mg/l
0.80
127
990
385
3472
1.29
2.40
4.1
4.0
9.08
9.34
mm/h
0.17
365
3218
254
2191
1.27
2.22
2.6
2.6
—
—
—
0
0
515
4855
1.36
2.18
13.6
12.1
139.59
139.65
mmol/l
0.22
508
4712
516
4867
1.36
2.17
13.6
12.2
3.96
3.93
mmol/l
1.17
506
4705
534
5073
1.38
2.07
12.1
11.1
21.24
21.65
mg/l
0.11
414
3759
201
1698
1.27
2.05
5.0
5.6
37.07
37.08
g/l
0.01
184
1600
430
3968
1.27
2.05
5.7
4.7
38.59
38.52
mmol/mol
0.06
411
3743
86
653
1.37
1.88
8.1
8.2
1.08
1.12
mmol/l
0.63
76
618
128
1032
1.30
1.87
4.5
4.1
9.26
11.46
mg/mmol
0.22
78
706
8
28
2.88
1.86
2.5
1.9
—
1224630.00
iu/ml
—
0
5
9
35
2.59
1.80
7.2
5.1
1.09
1.73
ug/l
—
9
35
338
3062
1.23
1.78
4.6
3.9
279.63
915.27
e6/l
—
8
40
458
4301
1.25
1.65
3.8
3.6
—
—
—
0
0
458
4306
1.24
1.61
4.3
3.6
5.75
5.73
mmol/l
0.09
437
3976
192
1655
1.23
1.60
11.8
9.3
1.18
1.13
inr
0.41
68
515
90
707
1.32
1.60
3.6
3.3
55.50
616.12
ng/l
2.87
62
458
5
15
3.35
1.52
1.0
3.7
233.60
210.47
u/l
—
5
15
139
1165
1.25
1.49
1.7
1.7
1.47
1.36
mmol/l
0.60
115
1033
17
94
1.83
1.48
3.9
3.0
61.75
18.60
mu/l
0.48
17
89
171
1469
1.23
1.46
1.9
1.8
100.16
97.44
pmol/l
0.29
93
754
213
1873
1.21
1.44
7.4
7.4
1.23
1.22
mmol/l
0.78
192
1742
76
593
1.32
1.42
1.5
1.6
1179.09
1155.01
nmol/l
0.09
61
465
543
5232
1.31
1.40
8.9
9.0
27.90
27.04
u/l
0.37
530
5066
7
29
2.43
1.39
3.0
2.4
558.00
743.34
u/ml
—
7
29
244
2182
1.20
1.36
5.0
6.4
12.76
11.14
umol/l
0.83
234
2062
51
377
1.38
1.36
7.7
9.5
1.15
0.85
mmol/l
0.27
40
305
186
1623
1.21
1.35
3.3
3.7
31.19
30.23
u/l
0.23
180
1545
0
39
0.00
1.34
0.0
1.3
—
—
—
0
0
54
406
1.36
1.30
3.1
2.1
11.07
12.45
nmol/l
0.58
46
375
5
18
2.79
1.28
1.0
1.0
—
—
—
0
0
6
25
2.41
1.24
1.3
1.3
—
—
—
0
0
9
45
2.01
1.23
1.3
1.5
—
—
—
0
0
473
4508
1.21
1.21
4.4
4.0
2.73
2.80
mmol/l
1.04
450
4236
217
1939
1.18
1.20
3.3
2.6
74.25
72.06
nmol/l
0.51
205
1793
203
1804
1.19
1.19
3.6
3.2
—
—
—
0
0
19
296
0.63
1.18
1.4
1.8
—
—
—
0
0
469
4472
1.20
1.17
4.0
3.8
4.55
4.66
mmol/l
1.47
446
4233
68
541
1.29
1.14
3.1
2.8
23.11
24.74
%
0.48
56
483
56
436
1.31
1.10
2.0
1.9
—
—
—
0
0
154
1347
1.19
1.08
4.4
3.6
7.80
8.39
mmol/l
0.78
136
1197
261
2385
1.16
1.07
3.3
2.9
174.35
85.11
ug/l
0.41
244
2241
6
122
0.49
1.06
1.2
1.1
—
11.34
—
0
5
313
2902
1.16
1.06
7.7
9.2
3.71
3.85
e9/l
0.63
276
2519
55
430
1.31
1.06
2.0
1.8
—
—
—
0
0
73
593
1.26
1.05
2.8
2.7
2.47
2.44
g/l
0.17
68
555
358
3355
1.16
1.04
3.1
3.4
41.47
39.35
u/l
0.19
347
3195
63
503
1.28
1.04
4.3
7.1
1.51
1.50
mmol/l
0.01
56
401
15
91
1.66
1.01
1.4
1.4
—
—
—
0
0
15
91
1.66
1.01
1.4
1.4
—
—
—
0
0
79
652
1.24
1.00
2.8
2.6
14.42
14.67
umol/l
0.13
73
612
9
49
1.85
0.99
1.9
1.2
—
—
—
0
0
74
608
1.25
0.97
2.0
1.9
—
—
—
0
0
464
4446
1.17
0.97
3.9
3.7
1.42
1.45
mmol/l
0.73
440
4185
9
50
1.81
0.97
1.2
1.2
—
—
—
0
0
9
50
1.81
0.97
1.9
1.2
—
—
—
0
0
12
198
0.60
0.97
1.2
1.2
—
—
—
0
0
152
1341
1.18
0.97
2.7
3.0
2.37
2.36
mmol/l
0.64
137
1208
75
618
1.24
0.96
2.0
1.9
—
—
—
0
0
153
1352
1.17
0.95
2.8
3.0
52.96
33.51
ng/l
0.39
78
756
0
32
0.00
0.95
0.0
2.9
—
46.18
—
0
32
10
172
0.57
0.94
3.1
2.1
—
—
—
0
0
17
110
1.56
0.91
2.0
1.5
—
—
—
0
0
15
94
1.61
0.91
1.9
1.4
8.89
18.76
u/l
1.79
15
80
98
837
1.20
0.90
3.8
3.4
966.36
751.74
ng/l
0.31
78
698
5
104
0.48
0.89
1.0
1.3
—
—
—
0
0
8
42
1.92
0.89
1.6
2.6
106.13
105.71
mmol/l
—
8
42
11
64
1.73
0.86
1.2
1.3
—
—
—
0
0
87
738
1.21
0.86
2.1
2.0
—
—
—
0
0
171
1539
1.15
0.84
1.6
1.5
1.58
2.46
u/ml
0.52
36
371
8
45
1.79
0.84
1.1
1.2
213.28
189.72
pmol/l
—
8
45
0
24
0.00
0.79
0.0
1.0
—
1490.04
—
0
24
588
5790
1.31
0.74
17.9
16.3
252.93
257.91
e9/l
1.18
576
5629
14
92
1.53
0.73
3.0
3.6
16.20
30.04
mg/l
—
7
57
267
2496
1.12
0.72
6.1
6.6
53.86
54.70
%
0.59
256
2373
271
2537
1.12
0.72
6.4
6.8
31.73
30.70
%
0.92
259
2414
7
40
1.76
0.71
2.0
1.3
—
—
—
0
0
588
5794
1.30
0.69
18.0
16.3
40.44
41.38
%
0.57
537
5474
5
27
1.86
0.68
1.2
1.2
—
—
—
0
0
444
4284
1.13
0.68
3.5
3.4
1.27
1.25
mmol/l
0.22
417
4021
5
28
1.79
0.66
1.0
1.5
—
—
—
0
0
5
28
1.79
0.66
7.4
9.6
—
—
—
0
0
588
5799
1.28
0.64
17.8
16.2
4.61
4.59
e12/l
0.74
574
5628
9
137
0.65
0.61
1.8
1.3
—
26.70
—
0
6
27
344
0.78
0.61
1.4
1.4
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
176
1623
1.12
0.60
2.2
1.8
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
24
307
0.77
0.56
1.7
2.7
87.63
73.27
ml/min/173m2
—
8
129
11
73
1.52
0.56
2.5
3.5
18.18
16.80
%
—
5
38
8
55
1.46
0.56
2.4
2.9
—
—
—
0
0
6
37
1.63
0.55
2.3
2.6
36666.67
40243.38
ug/l
—
6
37
112
1010
1.13
0.55
2.6
2.9
343.91
5706.52
umol/l
3.54
104
913
84
743
1.15
0.55
3.7
3.1
0.63
1.07
e6/l
0.96
49
414
12
82
1.47
0.54
1.2
1.1
—
—
—
0
0
121
1098
1.13
0.54
2.3
2.3
—
—
—
0
0
34
277
1.24
0.54
1.5
1.6
—
—
—
0
0
412
4253
0.91
0.53
10.8
9.5
92.86
92.60
ml/min/173m2
0.08
319
3331
50
425
1.19
0.53
2.3
2.3
31.62
145.79
u/l
0.52
42
366
17
226
0.75
0.53
1.3
1.4
—
—
—
0
0
62
538
1.17
0.52
2.6
4.7
17.22
8.26
umol/l
0.49
54
469
20
256
0.77
0.49
1.3
1.4
206.54
253.63
miu/ml
0.33
11
124
7
46
1.53
0.48
1.0
1.0
—
—
—
0
0
22
173
1.28
0.47
1.2
1.1
3.08
2.17
u/ml
0.12
15
113
12
86
1.40
0.44
7.6
4.1
4.92
4.97
kpa
0.14
12
86
5
31
1.62
0.43
1.0
1.6
—
—
—
0
0
48
551
0.86
0.43
2.6
2.7
0.73
0.72
ug/l
0.03
27
318
6
95
0.63
0.42
1.8
1.4
—
—
—
0
0
19
239
0.79
0.42
1.4
1.6
3.01
3.28
mg/l
0.08
14
162
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
47
538
0.86
0.41
1.4
1.5
—
—
—
0
0
47
409
1.16
0.40
5.8
6.2
1.39
1.60
mmol/l
0.18
31
290
5
36
1.39
0.38
1.0
1.1
—
1.07
—
0
14
24
197
1.23
0.38
1.1
1.2
2.25
3.38
u/ml
0.23
15
124
8
116
0.69
0.37
1.0
1.1
—
—
—
0
0
132
1232
1.09
0.37
3.8
3.4
0.00
0.01
estimate
0.88
40
471
25
299
0.83
0.36
3.0
4.1
2.79
31.90
ug/l
1.00
16
232
13
99
1.32
0.35
4.4
2.7
—
—
—
0
0
11
145
0.75
0.35
2.5
1.9
—
—
—
0
0
21
172
1.23
0.34
2.9
4.8
0.73
0.66
%
0.62
21
172
31
265
1.18
0.34
1.7
2.1
6.08
8.86
ug/l
0.37
25
237
6
45
1.34
0.34
1.0
1.0
—
—
—
0
0
93
858
1.10
0.34
1.7
1.5
—
—
—
0
0
6
88
0.68
0.33
3.0
1.7
—
—
—
0
0
7
52
1.35
0.31
1.3
1.4
—
—
—
0
0
21
175
1.21
0.30
1.0
1.2
3.88
0.66
u/ml
0.43
14
109
15
121
1.25
0.28
1.5
1.4
278.00
332.67
ug/g
—
9
65
11
85
1.30
0.28
5.8
1.6
—
—
—
0
0
17
203
0.83
0.26
2.5
1.5
1.09
1.19
g/l
0.72
17
192
85
795
1.08
0.24
1.2
1.2
9.75
10.22
u/ml
0.02
36
319
48
437
1.11
0.24
1.4
1.3
100.16
142.75
iu/ml
0.63
21
178
6
83
0.72
0.24
1.0
1.1
—
—
—
0
0
14
169
0.82
0.24
1.4
1.5
—
0.03
—
0
37
130
1237
1.06
0.23
2.3
2.3
—
—
—
0
0
105
992
1.07
0.23
1.6
2.2
1.22
1.12
mg/l
0.07
80
733
102
963
1.07
0.23
4.4
4.1
1.65
1.76
ug/l
0.24
93
865
21
181
1.17
0.23
1.1
1.2
14.55
8.25
u/ml
0.62
15
125
5
40
1.25
0.22
1.4
1.7
—
—
—
0
0
5
40
1.25
0.22
1.4
1.7
—
—
—
0
0
5
40
1.25
0.22
1.4
1.7
—
—
—
0
0
16
188
0.85
0.21
1.4
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
11.09
—
0
11
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
25.68
—
0
10
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
8
104
0.77
0.21
1.1
1.9
—
—
—
0
0
5
43
1.16
0.21
1.0
1.1
—
—
—
0
0
116
1105
1.06
0.21
2.0
2.1
356.07
271.29
u/l
0.15
107
1051
17
198
0.85
0.21
2.5
1.5
0.21
0.23
g/l
0.53
17
189
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
22
193
1.15
0.20
2.4
5.0
3.07
3.27
g/l
0.33
22
187
46
424
1.09
0.19
11.7
10.1
24.73
24.92
mmol/l
0.21
46
424
10
122
0.82
0.19
1.6
2.5
167.10
268.18
ug/l
—
10
112
10
122
0.82
0.19
2.2
1.8
—
—
—
0
0
6
52
1.16
0.19
2.2
1.7
—
—
—
0
0
7
59
1.19
0.18
2.1
1.6
—
—
—
0
0
19
216
0.88
0.18
2.0
2.4
16.04
42.81
u/ml
1.50
19
206
11
91
1.21
0.17
1.2
1.7
—
—
—
0
0
11
91
1.21
0.17
1.2
1.7
—
—
—
0
0
10
82
1.22
0.17
1.6
1.4
—
—
—
0
0
13
152
0.85
0.17
2.0
2.0
—
—
—
0
0
24
267
0.89
0.17
1.2
1.4
—
—
—
0
0
24
267
0.89
0.17
1.2
1.4
—
—
—
0
0
8
70
1.14
0.16
1.0
1.7
—
—
—
0
0
8
70
1.14
0.16
1.0
1.7
—
—
—
0
0
11
92
1.20
0.16
1.5
2.3
—
—
—
0
0
11
130
0.84
0.16
3.4
3.3
614.05
1794.48
u/ml
0.43
11
110
24
266
0.90
0.16
1.2
1.4
—
—
—
0
0
24
266
0.90
0.16
1.2
1.4
—
—
—
0
0
9
80
1.13
0.15
2.1
1.2
—
—
—
0
0
9
81
1.11
0.15
4.7
5.3
441.11
377.74
umol/l
—
9
74
38
409
0.92
0.15
1.1
1.1
—
—
—
0
0
119
1148
1.05
0.14
2.3
2.1
—
—
—
0
0
41
439
0.93
0.14
7.2
5.7
—
—
—
0
0
134
1382
0.96
0.13
4.1
3.4
52.62
96.99
e6/l
0.38
107
1053
48
452
1.07
0.13
3.5
3.7
31.88
31.37
%
0.11
41
327
10
117
0.85
0.13
1.0
1.1
—
—
—
0
0
9
107
0.84
0.13
1.7
1.2
—
—
—
0
0
11
127
0.86
0.12
2.3
1.6
—
—
—
0
0
32
297
1.08
0.12
1.8
1.9
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
12
104
1.16
0.12
2.8
5.8
0.24
0.33
u/ml
—
6
57
59
618
0.95
0.11
2.2
2.4
2.45
2.43
mmol/l
0.49
52
530
11
126
0.87
0.11
1.1
2.4
3.50
3.64
mmol/l
0.47
11
119
49
516
0.95
0.11
1.3
1.5
—
—
—
0
0
21
192
1.10
0.11
1.5
1.6
176.14
218.50
u/ml
0.57
14
97
74
769
0.96
0.11
1.5
1.7
1.42
1.43
%
0.11
65
696
12
106
1.13
0.10
7.4
7.9
—
2690.70
u/ml
—
0
10
5
45
1.11
0.10
1.2
1.8
—
—
—
0
0
84
813
1.04
0.09
1.3
1.2
16.41
28.77
iu/ml
1.64
32
249
155
1582
0.97
0.09
4.3
3.4
—
—
—
0
0
40
380
1.06
0.09
2.5
2.7
—
—
—
0
0
28
298
0.94
0.08
1.3
1.5
—
—
—
0
0
123
1259
0.97
0.08
4.2
3.4
0.52
0.33
e6/l
0.38
97
940
5
60
0.83
0.08
3.2
2.1
—
—
—
0
0
13
117
1.11
0.08
1.0
1.2
—
—
—
0
0
21
195
1.08
0.08
1.2
1.5
—
—
—
0
0
17
156
1.09
0.08
1.5
1.6
—
—
—
0
0
7
68
1.03
0.08
1.1
1.5
—
—
—
0
0
6
71
0.84
0.07
2.3
1.6
—
—
—
0
0
6
72
0.83
0.07
1.3
1.4
—
—
—
0
0
6
73
0.82
0.07
2.8
1.7
—
—
—
0
0
41
392
1.05
0.07
2.5
2.4
13189.05
4309.03
u/l
0.35
15
155
14
153
0.91
0.07
1.1
1.1
—
—
—
0
0
21
196
1.07
0.07
1.7
1.7
—
—
—
0
0
9
85
1.06
0.07
1.3
1.2
—
—
—
0
0
74
720
1.03
0.06
4.0
3.2
2.16
3.05
e6/l
0.75
41
394
19
177
1.08
0.06
1.7
1.4
—
—
—
0
0
78
760
1.03
0.06
4.2
3.9
21.69
21.52
%
0.03
32
311
11
99
1.11
0.06
5.1
3.6
3.13
4.09
e9/l
1.38
11
99
40
384
1.04
0.06
1.4
1.3
—
—
—
0
0
14
151
0.93
0.05
1.1
1.1
—
—
—
0
0
21
199
1.06
0.04
1.5
1.6
—
—
—
0
0
24
250
0.96
0.03
1.5
1.6
—
—
—
0
0
11
102
1.08
0.03
5.8
4.1
49.18
54.68
%
0.75
11
102
13
137
0.95
0.01
1.4
2.3
380.54
458.39
mg/l
0.54
13
129
17
163
1.04
0.01
1.8
1.7
—
231.43
—
0
7
22
227
0.97
0.01
1.7
1.6
—
—
—
0
0
19
184
1.03
0.00
1.6
1.4
—
—
—
0
0
22
224
0.98
0.00
1.5
1.4
—
—
—
0
0
12
123
0.98
0.00
2.0
1.7
—
—
—
0
0
16
157
1.02
0.00
2.0
1.7
—
—
—
0
0
17
168
1.01
0.00
1.8
1.8
—
—
—
0
0
6
68
0.88
0.00
2.2
1.5
—
—
—
0
0
5
50
1.00
0.00
1.8
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
9.78
—
0
6
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
250.00
—
0
5
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
8
80
1.00
-0.00
2.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
69
0.87
-0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.8
—
49.98
—
0
6
0
9
0.00
-0.00
0.0
3.2
—
24.67
—
0
9
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint K11_MN_PROGN and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_MN_PROGN | 0.831 [0.63, 1.1] | 0.196 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 4813 males with K11_MN_PROGN died.
Mortality risk
Mortality risk for people of age
years, who have K11_MN_PROGN.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.156% |
| 5 | No data | 0.989% |
| 10 | No data | 2.462% |
| 15 | No data | 4.535% |
| 20 | No data | 7.645% |
Relationships between endpoints
↥Index endpoint: K11_MN_PROGN – Mandibular prognathia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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