No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
598 |
4. Check minimum number of eventsNone |
598 |
5. Include endpointsNone |
598 |
6. Filter based on genotype QC (FinnGen only) |
598 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF10
Mandibular prognathia
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10540 | 4767 | 5746 |
| Only index persons | 9023 | 4093 | 4930 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.14 | 0.16 |
| Only index persons | 0.17 | 0.15 | 0.19 |
| Median age at first event (years) | |||
| Whole population | 13.23 | 13.24 | 13.15 |
| Only index persons | 14.49 | 14.49 | 14.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 598 | 354 | 244 |
| Unadjusted period prevalence (%) | 0.12 | 0.12 | 0.11 |
| Median age at first event (years) | 30.51 | 29.12 | 32.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 514
- Matched controls
- 5138
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K07.11
ICD-10 Finland
Retrognathism (mandibular)(maxillary)
+∞
323.0
514
*
K07.14
ICD-10 Finland
Retrognaty, maxillary
198.5
182.4
181
14
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
32.2
164.0
224
120
SBB10
NOMESCO Finland
Teeth copy
16.4
163.2
317
458
EEC05
NOMESCO Finland
Le Fort I osteotomy
237.6
127.0
126
7
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
16.0
112.6
198
193
EB1MA
NOMESCO Finland
Cephalometry with X-ray
15.0
109.7
199
207
SJD00
NOMESCO Finland
Removal or reattacment of arrow in fixed orthodontisk device
14.5
104.8
193
205
SJD10
NOMESCO Finland
Attachment of arrow to fixed orthodontisk device
12.9
95.6
186
217
EDC10
NOMESCO Finland
Sagittal osteotomy of ramus of mandible
165.9
92.6
95
7
SJD20
NOMESCO Finland
Attachment of modifiable arrow of fixed orthodontisk device
14.2
88.3
161
160
SJC50
NOMESCO Finland
Removal of orthodontisk device with at least 7 brackets
13.3
86.6
163
173
SJC10
NOMESCO Finland
Orthodontic bandage in one tooth
13.6
85.1
158
162
SJX10
NOMESCO Finland
Short check-up visit for orthodontisk therapy
8.9
77.3
188
314
SAA04
NOMESCO Finland
Special inverstigation of mouth
9.3
73.6
171
262
SJD40
NOMESCO Finland
Fixation of ready made palatinal or lingual arrow
9.9
70.1
154
212
SJD30
NOMESCO Finland
Demanding attachment of arrow to fixed orthodontisk device
15.5
69.9
120
99
SJB00
NOMESCO Finland
Fitting of loose orthodontic device with user information
9.6
66.8
149
209
K07.10
ICD-10 Finland
Asymmetry of jaw
102.8
65.8
71
8
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
12.5
63.3
120
122
K07.24
ICD-10 Finland
Open bite
22.3
59.6
88
47
SAA03
NOMESCO Finland
Extended examination of mouth
4.3
51.6
371
1920
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
9.9
51.1
109
136
SJC00
NOMESCO Finland
Bracket with fixed attachment
86.1
49.0
54
7
K07.1
ICD-10 Finland
Anomalies of jaw-cranial base relationship
184.1
48.8
50
*
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
6.3
46.0
136
276
K07.13
ICD-10 Finland
Retrognaty, mandibular
13.9
44.9
79
66
SXC05
NOMESCO Finland
Other oral or dental procedure
5.3
42.7
151
377
SJA04
NOMESCO Finland
Very demanding plan for orthodontic care
148.1
39.3
41
*
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
6.1
38.4
114
228
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
6.4
37.4
106
199
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
7.1
36.6
96
162
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
3.3
36.5
317
1679
SJX20
NOMESCO Finland
Check-up visit for orthodontisk therapy
6.6
35.0
96
172
SJB60
NOMESCO Finland
External device grinding and adaptation
7.2
34.3
88
143
SJA03
NOMESCO Finland
Demanding plan for orthodontic care
96.6
33.2
36
*
K07.01
ICD-10 Finland
Hyperplasia, hypoplasia mandibular
124.9
33.1
35
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.1
32.5
264
1293
EFB40
NOMESCO Finland
Removal of internal or external fixation device from facial bones
77.0
32.3
36
5
K07.21
ICD-10 Finland
Anomalies of dental arch relationship
32.5
32.2
42
14
K07.60
ICD-10 Finland
Snapping jaw
7.3
31.5
79
124
K07.18
ICD-10 Finland
Another anomaly in the relationship between jaw and skull base
117.3
31.0
33
*
SJC40
NOMESCO Finland
Removal of orthodontisk device with at most 6 brackets
5.6
30.6
96
202
SJA01
NOMESCO Finland
Estimation of need for orthodontic care
38.6
28.7
36
10
SJX21
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment
5.4
27.5
89
193
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
5.6
27.3
85
176
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
6.8
27.2
72
121
SJX11
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment, restricted
4.4
25.9
102
272
K07.12
ICD-10 Finland
Prognathism (mandibular)(maxillary)
142.2
25.9
27
*
K07.03
ICD-10 Finland
Micrognatia (hypoplasia) of the upper jaw
+∞
24.1
23
*
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
7.8
23.8
56
79
K07.30
ICD-10 Finland
Spacing, abnormal of tooth or teeth
4.4
22.1
86
225
K00.00
ICD-10 Finland
Hypodontia
10.0
20.5
41
44
K07.19
ICD-10 Finland
Anomalies in the relationship between jaw and skull base UNS
207.6
19.7
20
*
SAC03
NOMESCO Finland
Separate planning of oral and dental treatment, very demanding
14.8
19.3
32
23
EBB10
NOMESCO Finland
Insertion of dental implant
14.8
19.3
32
23
SAC02
NOMESCO Finland
Separate planning of oral and dental treatment, demanding
5.5
17.6
53
105
EB1WA
NOMESCO Finland
NA
24.0
16.6
23
10
SJA02
NOMESCO Finland
Plan for orthodontic care
87.8
15.7
17
*
SXC03
NOMESCO Finland
Other oral or dental procedure
14.7
14.7
24
17
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
10.9
13.4
25
24
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
11.4
13.1
24
22
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
13.5
13.0
22
17
EBB15
NOMESCO Finland
Insertion of dental implant abutment
19.7
13.0
19
10
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prothetic work
6.1
12.9
35
61
SPB10
NOMESCO Finland
Production of temporary crone to tooth
21.9
12.1
17
8
K07.69
ICD-10 Finland
Dislocation of the jaw joint UNS
10.9
11.9
22
21
SAA01
NOMESCO Finland
Simple examination of mouth
2.1
11.7
399
3210
SAA02
NOMESCO Finland
Basic examination of mouth
2.1
11.5
408
3316
SJX00
NOMESCO Finland
Reparation of orthodontiskt device by dentist
8.6
11.4
24
29
SJB10
NOMESCO Finland
Fitting of loose orthodontic device with user information, demanding
4.9
11.3
36
77
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
10.9
149
839
SPC20
NOMESCO Finland
Attachment of crone of tooth to implant
18.3
10.8
16
9
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
22.0
10.7
15
7
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
4.3
10.3
37
90
SAC01
NOMESCO Finland
Separate planning of oral and dental treatment, standard
3.4
10.2
49
153
SPC10
NOMESCO Finland
Attachment of standard crone of tooth
11.6
10.1
18
16
K07.4
ICD-10 Finland
Malocclusion, unspecified
6.2
9.9
26
44
WZA90
NOMESCO Finland
Other doctors statement
2.0
9.8
153
902
SJD50
NOMESCO Finland
Production and attachment of palatinal or lingual arrow
6.4
9.8
25
41
SHA04
NOMESCO Finland
Correction of physiology of bite - very demanding therapy visit
10.3
9.6
18
18
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
3.4
9.2
45
143
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
2.6
9.2
70
295
K07.04
ICD-10 Finland
Macrognathism (mandibular)(maxillary)
50.9
8.7
10
*
K01.0
ICD-10 Finland
Embedded teeth
5.3
8.6
25
49
EBA10
NOMESCO Finland
Surgical removal of tooth
2.2
8.3
93
473
SJE90
NOMESCO Finland
Finishing face of orthodontick therapy
12.0
8.1
14
12
WX110
NOMESCO Finland
Local anesthesy
1.8
8.0
369
3028
EBA00
NOMESCO Finland
Extraction of tooth
1.8
7.9
200
1371
SBB20
NOMESCO Finland
Tooth X-ray examination in conjunction with visit to dentist
9.6
7.8
15
16
OIKK
NOMESCO Finland
NA
2.5
7.8
59
249
Z96.5
ICD-10 Finland
Presence of tooth-root and mandibular implants
45.7
7.7
9
*
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
12.1
7.6
13
11
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.2
7.5
77
376
SPF00
NOMESCO Finland
Repatation of teeth prosthesis
7.0
7.3
17
25
EEC02
NOMESCO Finland
Rapid expansion of maxilla
+∞
7.3
7
*
EDC30
NOMESCO Finland
Genioplasty
+∞
7.3
7
*
K07.23
ICD-10 Finland
Deep bite
2.7
7.3
49
192
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.8
7.2
151
970
K07.26
ICD-10 Finland
Anomalies of dental arch relationship
20.3
7.2
10
5
SDA02
NOMESCO Finland
Parodonthologic therapy
1.7
6.8
182
1261
SPA20
NOMESCO Finland
Selection and insertion of implantdistans
22.8
6.7
9
*
SPC40
NOMESCO Finland
Preparation of first or second intermediate attachment tooth for bridge
22.8
6.7
9
*
F45.8
ICD-10 Finland
Other somatoform disorders
2.6
6.6
46
185
ZXA10
NOMESCO Finland
Bilateral
2.0
6.5
84
454
SJF01
NOMESCO Finland
Assessment of need for orthodontic treatment
2.5
6.5
48
200
ECW06
NOMESCO Finland
Insertion of mini-implant or miniscrew
+∞
6.3
6
*
K07.29
ICD-10 Finland
Anomaly in the relationship between the tooth arches UNS
+∞
6.3
6
*
K05.30
ICD-10 Finland
Periodontitis complex
2.3
6.2
56
260
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
50
230
2.28
6.49
2.9
3.1
130.6
147.2
ng/l
0.12
44
210
246
1974
1.42
4.13
7.3
7.7
1.2
1.2
mmol/l
1.78
214
1727
297
2495
1.38
3.67
4.7
4.9
6.5
6.4
mmol/l
0.18
275
2271
476
4377
1.43
3.09
4.9
4.4
1.8
2.1
mu/l
0.58
443
4077
16
62
2.62
3.06
1.9
1.6
13.2
13.1
%
0.07
16
62
101
722
1.48
3.06
1.7
1.6
413.8
18483857.8
pmol/l
0.79
86
633
413
3730
1.35
2.84
4.3
3.8
14.5
14.5
pmol/l
0.15
382
3423
370
3302
1.32
2.69
6.0
6.8
78.8
83.3
u/l
0.67
354
3113
262
2236
1.31
2.63
3.6
3.3
0.0
0.0
estimate
0.00
38
453
265
2267
1.30
2.60
3.6
3.3
0.0
0.0
estimate
0.50
37
448
472
4374
1.38
2.59
14.2
14.0
13.3
13.4
%
0.68
462
4292
160
1276
1.35
2.58
2.4
2.5
56.7
58.1
u/l
0.14
150
1194
262
2243
1.30
2.54
5.0
4.6
0.0
0.0
estimate
0.00
39
465
109
822
1.40
2.48
1.4
1.4
19.1
20.8
nmol/l
0.68
93
710
66
453
1.51
2.45
2.5
2.2
416.4
364.0
nmol/l
0.44
61
421
248
2124
1.29
2.35
3.9
4.0
—
—
—
0
0
132
1041
1.34
2.27
3.7
3.1
1.0
1.0
kg/l
0.94
18
130
34
202
1.72
2.26
2.2
1.6
—
—
—
0
0
126
989
1.35
2.24
4.7
4.3
9.2
11.9
mg/mmol
0.27
76
672
137
1095
1.33
2.15
2.5
2.2
2.5
2.8
mg/l
0.82
122
958
371
3367
1.27
2.10
4.1
4.0
9.2
9.4
mm/h
0.14
351
3122
517
4906
1.40
2.09
12.1
11.1
21.3
21.7
mg/l
0.10
402
3634
416
3832
1.28
2.07
5.8
4.7
38.5
38.5
mmol/mol
0.02
398
3615
194
1641
1.27
1.97
4.9
5.5
37.1
37.0
g/l
0.10
178
1542
496
4687
1.34
1.97
13.5
12.1
139.6
139.6
mmol/l
0.13
489
4547
497
4698
1.34
1.97
13.5
12.2
4.0
3.9
mmol/l
1.05
487
4540
327
2966
1.23
1.70
4.6
3.9
319.1
915.3
e6/l
—
7
40
81
621
1.35
1.69
7.8
8.2
1.1
1.1
mmol/l
0.85
71
588
208
1806
1.23
1.64
7.1
7.4
1.2
1.2
mmol/l
0.84
185
1672
442
4153
1.25
1.58
3.8
3.6
—
—
—
0
0
21
344
0.60
1.54
29.0
17.6
1.2
1.2
inr
—
5
54
17
93
1.85
1.53
3.9
3.0
61.8
18.7
mu/l
0.48
17
88
75
579
1.34
1.51
1.5
1.6
1188.1
1157.2
nmol/l
0.12
60
452
442
4167
1.23
1.45
4.2
3.6
5.7
5.7
mmol/l
0.03
421
3845
7
28
2.52
1.45
3.0
2.5
558.0
761.6
u/ml
—
7
28
7
28
2.52
1.45
1.7
1.9
—
1224630.0
—
0
5
86
682
1.30
1.44
3.6
3.3
56.2
616.5
ng/l
2.72
61
443
50
365
1.40
1.42
7.8
9.4
1.1
0.8
mmol/l
0.28
39
293
0
38
0.00
1.34
0.0
1.3
—
—
—
0
0
165
1426
1.22
1.33
1.9
1.8
100.7
97.4
pmol/l
0.36
91
730
133
1126
1.23
1.31
1.6
1.7
1.4
1.3
mmol/l
0.53
110
999
179
1563
1.21
1.30
3.1
3.7
30.3
30.2
u/l
0.01
173
1487
5
18
2.79
1.28
1.0
1.0
—
—
—
0
0
9
44
2.06
1.27
1.3
1.5
—
—
—
0
0
51
386
1.35
1.20
3.2
2.1
11.0
12.6
nmol/l
0.62
42
349
74
593
1.28
1.17
2.0
1.9
—
—
—
0
0
235
2120
1.18
1.17
5.0
6.4
12.7
11.1
umol/l
0.77
225
2001
15
87
1.74
1.16
1.4
1.4
—
—
—
0
0
15
87
1.74
1.16
1.4
1.4
—
—
—
0
0
523
5058
1.27
1.15
8.9
9.0
27.1
26.9
u/l
0.10
510
4900
500
4813
1.24
1.14
13.6
12.2
40.0
40.4
%
0.56
382
3898
55
425
1.32
1.14
1.9
1.8
—
—
—
0
0
149
1296
1.20
1.12
4.2
3.6
7.7
8.4
mmol/l
0.80
131
1135
455
4345
1.20
1.10
4.4
4.1
2.7
2.8
mmol/l
0.83
432
4068
54
419
1.32
1.09
2.0
1.8
—
—
—
0
0
19
289
0.65
1.07
1.4
1.8
—
—
—
0
0
451
4310
1.19
1.05
4.0
3.8
4.6
4.6
mmol/l
1.10
428
4065
208
1877
1.17
1.01
3.2
2.6
74.5
72.0
nmol/l
0.58
196
1736
9
48
1.89
1.01
1.2
1.2
—
—
—
0
0
148
1301
1.18
0.99
2.8
3.1
53.5
34.5
ng/l
0.37
77
723
65
525
1.27
0.99
3.1
2.7
23.5
24.8
%
0.34
53
469
5
23
2.18
0.98
1.4
1.3
—
—
—
0
0
11
186
0.58
0.97
1.2
1.2
—
—
—
0
0
0
31
0.00
0.96
0.0
2.9
—
47.2
—
0
31
193
1738
1.16
0.96
3.7
3.2
—
—
—
0
0
60
482
1.27
0.96
3.8
7.2
1.8
1.5
mmol/l
0.26
50
378
86
721
1.23
0.95
2.1
2.0
—
—
—
0
0
73
603
1.24
0.93
1.9
1.9
—
—
—
0
0
447
4285
1.17
0.92
3.9
3.7
1.4
1.5
mmol/l
0.63
423
4020
10
170
0.58
0.91
3.1
2.2
—
—
—
0
0
5
101
0.49
0.90
1.0
1.3
—
—
—
0
0
70
578
1.24
0.89
2.9
2.6
2.5
2.4
g/l
0.13
65
541
251
2316
1.14
0.88
3.3
2.9
179.6
84.2
ug/l
0.43
234
2174
11
64
1.73
0.86
1.2
1.3
—
—
—
0
0
76
636
1.22
0.86
2.9
2.6
14.4
14.6
umol/l
0.10
70
593
146
1298
1.17
0.85
2.7
3.0
2.4
2.4
mmol/l
0.80
132
1163
342
3227
1.14
0.85
3.0
3.4
40.0
38.8
u/l
0.10
331
3072
94
806
1.20
0.84
3.9
3.4
990.4
767.5
ng/l
0.32
76
673
8
47
1.71
0.81
2.0
1.2
—
—
—
0
0
0
24
0.00
0.79
0.0
1.0
—
1490.0
—
0
24
8
48
1.68
0.79
2.0
1.2
—
—
—
0
0
14
90
1.57
0.78
3.0
3.6
16.2
29.3
mg/l
—
7
55
165
1493
1.15
0.76
1.6
1.5
1.6
2.5
u/ml
0.48
33
359
299
2811
1.13
0.76
7.2
9.3
3.7
3.8
e9/l
0.55
262
2436
5
26
1.93
0.70
1.2
1.2
—
—
—
0
0
5
27
1.86
0.68
7.4
9.9
—
—
—
0
0
428
4126
1.13
0.68
3.5
3.4
1.3
1.2
mmol/l
0.15
403
3870
14
94
1.50
0.67
1.9
1.4
9.2
18.8
u/l
1.61
14
80
5
28
1.79
0.66
1.0
1.5
—
—
—
0
0
12
79
1.53
0.63
1.2
1.1
—
—
—
0
0
5
30
1.67
0.61
1.0
1.7
—
—
—
0
0
5
30
1.67
0.61
5.4
6.7
—
33.5
—
0
8
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
8
53
1.52
0.58
2.4
3.0
—
—
—
0
0
23
296
0.77
0.57
1.6
2.7
84.6
73.6
ml/min/173m2
—
7
121
27
340
0.78
0.56
1.4
1.4
—
—
—
0
0
33
267
1.25
0.55
1.5
1.6
—
—
—
0
0
44
521
0.83
0.53
1.4
1.5
—
—
—
0
0
6
39
1.54
0.53
2.7
2.5
—
—
—
0
0
49
416
1.19
0.53
2.3
2.4
31.2
148.3
u/l
0.52
41
358
9
136
0.66
0.52
1.8
1.3
—
26.7
—
0
6
15
109
1.39
0.51
1.9
1.5
—
—
—
0
0
116
1055
1.12
0.51
2.2
2.3
—
—
—
0
0
81
722
1.14
0.49
3.6
3.1
0.7
1.1
e6/l
0.88
47
402
24
190
1.27
0.48
1.1
1.2
0.3
2.1
u/ml
1.77
13
97
169
1574
1.10
0.48
2.1
1.8
—
—
—
0
0
7
46
1.53
0.48
1.0
1.0
—
—
—
0
0
398
4101
0.91
0.48
10.8
9.5
92.8
92.6
ml/min/173m2
0.07
307
3197
18
232
0.77
0.46
1.4
1.6
1.9
3.3
mg/l
1.79
13
155
10
142
0.70
0.46
2.0
1.9
—
—
—
0
0
13
94
1.39
0.46
4.4
2.7
—
—
—
0
0
17
219
0.77
0.44
1.3
1.4
—
—
—
0
0
45
521
0.85
0.44
2.7
2.7
0.7
0.7
ug/l
0.02
27
307
7
51
1.38
0.44
1.3
1.5
—
—
—
0
0
11
151
0.72
0.43
1.1
1.1
—
—
—
0
0
107
980
1.11
0.43
2.6
2.9
343.3
5938.2
umol/l
3.54
99
875
11
149
0.73
0.40
1.1
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
5
35
1.43
0.39
1.4
2.4
17.8
2.8
nmol/l
—
5
35
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
20
247
0.80
0.38
1.3
1.4
206.5
259.7
miu/ml
0.38
11
120
5
36
1.39
0.38
1.0
1.1
—
1.1
—
0
14
6
42
1.43
0.35
1.0
1.0
—
—
—
0
0
58
520
1.13
0.34
2.4
4.8
17.3
8.3
umol/l
0.44
50
454
114
1062
1.09
0.34
2.0
2.1
361.4
270.8
u/l
0.16
105
1009
128
1201
1.08
0.32
2.3
2.3
—
—
—
0
0
16
197
0.81
0.31
2.6
1.5
1.1
1.2
g/l
0.52
16
188
49
439
1.13
0.30
3.4
3.8
31.9
31.6
%
0.07
41
309
38
430
0.88
0.30
7.7
5.7
—
—
—
0
0
97
904
1.09
0.29
4.6
4.2
1.7
1.8
ug/l
0.16
88
810
8
110
0.72
0.29
1.0
1.1
—
—
—
0
0
7
57
1.23
0.29
2.1
1.6
—
—
—
0
0
25
291
0.85
0.29
3.0
4.0
2.8
32.8
ug/l
1.00
16
225
11
85
1.30
0.28
5.8
1.6
—
—
—
0
0
10
77
1.30
0.26
1.6
1.4
—
—
—
0
0
12
149
0.80
0.26
1.6
2.1
—
—
—
0
0
16
192
0.83
0.26
2.6
1.5
0.2
0.2
g/l
0.57
16
185
90
842
1.08
0.25
1.7
1.5
—
—
—
0
0
35
392
0.89
0.25
1.1
1.0
—
—
—
0
0
6
81
0.74
0.24
1.0
1.1
—
—
—
0
0
32
284
1.13
0.24
1.8
1.9
—
—
—
0
0
6
85
0.70
0.24
3.0
1.8
—
—
—
0
0
83
777
1.08
0.23
1.2
1.2
9.6
10.3
u/ml
0.03
34
315
5
40
1.25
0.22
1.0
1.1
—
—
—
0
0
18
210
0.85
0.22
2.1
2.5
15.9
43.7
u/ml
1.51
18
200
21
182
1.16
0.21
1.5
1.6
176.1
221.1
u/ml
0.61
14
96
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
11.1
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
125
1193
1.06
0.21
3.9
3.4
0.0
0.0
estimate
0.88
38
456
8
101
0.79
0.21
1.1
1.9
—
—
—
0
0
15
177
0.84
0.21
1.5
1.3
—
—
—
0
0
117
1115
1.06
0.21
2.3
2.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
42
384
1.10
0.20
5.1
6.3
1.4
1.7
mmol/l
0.22
29
269
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
29
260
1.12
0.19
1.7
2.1
6.5
8.9
ug/l
0.28
23
233
6
51
1.18
0.19
2.2
1.7
—
—
—
0
0
11
91
1.21
0.17
1.5
2.3
—
—
—
0
0
100
956
1.06
0.17
1.6
2.2
1.2
1.1
mg/l
0.03
75
707
14
162
0.86
0.16
1.4
1.6
—
0.0
—
0
37
16
183
0.87
0.16
1.5
1.4
—
—
—
0
0
148
1528
0.96
0.15
4.3
3.5
—
—
—
0
0
9
81
1.11
0.15
1.3
1.2
—
—
—
0
0
10
118
0.84
0.14
2.2
1.8
—
—
—
0
0
24
264
0.91
0.14
1.2
1.4
—
—
—
0
0
24
264
0.91
0.14
1.2
1.4
—
—
—
0
0
27
295
0.91
0.14
1.3
1.5
—
—
—
0
0
21
189
1.12
0.14
1.5
1.6
—
—
—
0
0
12
103
1.17
0.14
7.4
8.0
—
2901.9
u/ml
—
0
9
24
263
0.91
0.13
1.2
1.4
—
—
—
0
0
24
263
0.91
0.13
1.2
1.4
—
—
—
0
0
43
403
1.07
0.13
11.1
10.2
24.7
25.0
mmol/l
0.25
43
403
45
423
1.07
0.13
1.3
1.3
100.2
144.5
iu/ml
0.66
21
174
9
106
0.85
0.13
1.7
1.2
—
—
—
0
0
118
1218
0.96
0.12
4.1
3.4
0.5
0.3
e6/l
0.41
93
901
19
171
1.11
0.12
1.7
1.4
—
—
—
0
0
11
127
0.86
0.12
3.4
3.2
614.1
1844.6
u/ml
0.44
11
107
21
191
1.10
0.12
1.2
1.5
—
—
—
0
0
13
114
1.14
0.12
1.0
1.2
—
—
—
0
0
82
792
1.04
0.10
1.2
1.2
16.0
28.0
iu/ml
1.53
31
239
21
193
1.09
0.10
1.7
1.7
—
—
—
0
0
10
114
0.88
0.09
1.6
2.4
167.1
274.3
ug/l
—
10
104
17
155
1.10
0.09
1.5
1.6
—
—
—
0
0
49
512
0.95
0.09
1.3
1.5
—
—
—
0
0
57
593
0.96
0.09
2.1
2.4
2.5
2.4
mmol/l
0.79
51
508
12
134
0.89
0.09
1.1
2.4
401.5
456.3
mg/l
0.34
12
127
11
123
0.89
0.08
2.3
1.6
—
—
—
0
0
7
66
1.06
0.08
1.1
1.5
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
11
98
1.12
0.07
2.8
5.2
0.2
0.3
u/ml
—
5
54
6
70
0.86
0.07
2.8
1.7
—
—
—
0
0
6
70
0.86
0.07
1.3
1.5
—
—
—
0
0
74
718
1.03
0.07
4.3
3.9
21.7
21.5
%
0.04
32
301
8
76
1.05
0.07
2.0
1.7
—
—
—
0
0
8
76
1.05
0.07
2.0
1.1
—
—
—
0
0
20
186
1.08
0.07
2.1
5.0
3.1
3.3
g/l
0.27
20
180
10
112
0.89
0.07
1.0
1.1
—
—
—
0
0
11
122
0.90
0.07
1.1
2.4
3.5
3.6
mmol/l
0.48
11
116
9
101
0.89
0.06
4.4
4.2
50.8
54.2
%
—
9
101
17
158
1.08
0.06
1.8
1.7
—
231.4
—
0
7
36
375
0.96
0.06
1.2
1.3
—
—
—
0
0
38
366
1.04
0.05
2.3
2.7
—
—
—
0
0
72
736
0.98
0.05
1.5
1.7
1.4
1.4
%
0.07
64
666
11
119
0.92
0.04
2.1
1.7
—
—
—
0
0
71
698
1.02
0.03
3.9
3.2
2.3
3.1
e6/l
0.69
39
381
21
203
1.04
0.01
2.0
4.7
96.2
91.4
%
0.65
21
198
17
164
1.04
0.00
1.8
1.8
—
—
—
0
0
24
246
0.97
0.00
1.5
1.6
—
—
—
0
0
39
384
1.02
0.00
2.4
2.4
14076.4
4450.0
u/l
0.36
14
150
22
224
0.98
0.00
1.8
1.7
—
—
—
0
0
31
306
1.01
0.00
1.2
1.2
—
41.9
—
0
15
15
152
0.99
0.00
2.1
1.7
—
—
—
0
0
40
402
0.99
0.00
3.9
4.4
271.1
238.1
u/l
0.56
40
387
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
7
78
0.90
0.00
5.3
5.3
439.3
378.4
umol/l
—
7
73
6
67
0.89
0.00
2.2
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
250.0
—
0
5
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
3.8
—
50.0
—
0
6
22
220
1.00
0.00
1.5
1.4
—
—
—
0
0
6
66
0.91
0.00
1.2
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
5
50
1.00
0.00
1.8
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
6
69
0.87
0.00
2.3
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
25.7
—
0
9
Mortality – FinRegistry
↥Association
Association between endpoint K11_MN_PROGN and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_MN_PROGN | 0.831 [0.63, 1.1] | 0.196 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 4813 males with K11_MN_PROGN died.
Mortality risk
Mortality risk for people of age
years, who have K11_MN_PROGN.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.156% |
| 5 | No data | 0.989% |
| 10 | No data | 2.462% |
| 15 | No data | 4.535% |
| 20 | No data | 7.645% |
Relationships between endpoints
↥Index endpoint: K11_MN_PROGN – Mandibular prognathia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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