obsolete_alopecia:
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
228 |
4. Check minimum number of eventsNone |
228 |
5. Include endpoints |
266 |
6. Filter based on genotype QC (FinnGen only) |
266 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L60-L75
- Name in latin
- Alopecia cicatrisans
Similar endpoints
↥List of similar endpoints to
Cicatricial alopecia [scarring hair loss]
based on the number of shared cases.
Similar with more cases:
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1938 | 1201 | 729 |
| Only index persons | 1789 | 1155 | 634 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.04 | 0.04 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 48.69 | 56.69 | 35.57 |
| Only index persons | 48.37 | 56.89 | 32.84 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 266 | 199 | 67 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.03 |
| Median age at first event (years) | 54.51 | 58.16 | 43.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 233
- Matched controls
- 2330
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L66.1
ICD-10 Finland
Lichen planopilaris
+∞
96.8
86
*
L66.9
ICD-10 Finland
Cicatricial alopecia, unspecified
+∞
55.5
51
*
D07AD01
ATC
clobetasol; topical
9.7
50.8
129
265
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
11.4
41.3
85
112
70404
ICD-8 Finland
Diseases of hair and hair follicles, Folliculitis NUD
+∞
36.4
34
*
L66.2
ICD-10 Finland
Folliculitis decalvans
+∞
33.1
31
*
L66.8
ICD-10 Finland
Other cicatricial alopecia
+∞
33.1
31
*
P01BA02
ATC
hydroxychloroquine; oral
7.9
29.4
74
129
D07AC01
ATC
betamethasone; topical
4.2
23.5
134
566
L66.0
ICD-10 Finland
Pseudopelade
+∞
19.0
18
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.7
14.1
71
247
D07AC13
ATC
mometasone; topical
3.1
13.8
101
463
L43.8
ICD-10 Finland
Other lichen planus
12.6
13.7
24
21
J01AA04
ATC
lymecycline; systemic
4.4
13.5
52
142
D07XC01
ATC
betamethasone, combinations; topical
4.1
13.1
55
162
E0000UV
ATC
NA
2.8
12.5
123
668
L63.9
ICD-10 Finland
Alopecia areata, unspecified
+∞
11.6
11
*
D10BA01
ATC
isotretinoin; oral
7.1
11.5
28
44
D07AB02
ATC
hydrocortisone butyrate; topical
2.7
10.9
95
468
L66.4
ICD-10 Finland
Folliculitis ulerythematosa reticulata
+∞
10.5
10
*
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
12.1
10.2
18
16
L71.8
ICD-10 Finland
Other rosacea
57.4
9.7
11
*
H04.10
ICD-10 Finland
Dry eye syndrome
3.9
9.6
41
122
XQ848
NOMESCO Finland
Dermatological photography
8.9
9.3
19
23
L21.8
ICD-10 Finland
Other seborrhoeic dermatitis
25.2
9.0
12
5
L43.9
ICD-10 Finland
Lichen planus, unspecified
9.6
8.7
17
19
L93.0
ICD-10 Finland
Discoid lupus erythematosus
28.7
8.6
11
*
L71.9
ICD-10 Finland
Rosacea, unspecified
11.4
7.4
13
12
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
5.7
7.3
20
38
L73.8
ICD-10 Finland
Other specified follicular disorders
+∞
6.3
6
*
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
13.0
6.1
10
8
D05BB02
ATC
acitretin; oral
5.8
6.1
16
29
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
32
77
4.59
12.64
1.2
1.2
2.0
3.4
u/ml
—
8
11
32
78
4.53
12.44
1.3
1.2
2.5
3.7
u/ml
0.43
12
15
33
84
4.34
12.14
1.2
1.2
3.7
1.0
u/ml
—
5
5
33
92
3.95
10.74
2.9
2.4
—
—
—
0
0
27
65
4.51
10.63
1.0
1.2
38.9
34.0
u/ml
—
7
8
217
1697
2.51
8.04
4.5
4.0
10.9
11.7
mm/h
0.59
206
1544
177
1281
2.14
7.80
8.0
9.3
3.6
3.9
e9/l
1.97
161
1119
220
1762
2.44
7.20
6.0
7.2
72.5
77.6
u/l
1.48
208
1637
88
519
2.04
6.53
1.4
1.2
0.9
1.5
u/ml
0.55
22
151
212
1771
1.97
4.76
4.7
4.0
14.3
14.8
pmol/l
2.65
194
1606
128
926
1.74
4.66
2.4
2.2
82.8
78.5
nmol/l
0.99
114
827
126
917
1.71
4.42
3.8
4.2
35.9
35.8
g/l
0.09
112
864
65
402
1.82
3.96
1.2
1.3
14.2
10.8
u/ml
0.13
24
159
24
107
2.37
3.50
1.0
1.0
—
—
—
0
0
115
868
1.57
3.21
1.9
1.9
96.7
97.6
pmol/l
0.08
43
423
63
413
1.69
3.09
1.3
1.3
21.3
35.6
iu/ml
1.10
25
141
72
500
1.60
2.80
2.1
1.9
2.6
3.3
mg/l
1.95
59
433
232
2097
1.83
2.79
5.8
4.8
1.8
2.5
mu/l
0.67
217
1907
251
2336
2.32
2.68
15.7
14.8
3.9
4.0
mmol/l
0.63
245
2269
40
242
1.77
2.60
26.0
19.0
1.2
1.3
inr
—
9
34
135
1094
1.48
2.52
5.3
6.5
1.2
1.2
mmol/l
0.16
116
929
249
2324
2.12
2.40
15.7
14.8
139.7
139.8
mmol/l
0.25
241
2261
10
35
2.93
2.33
4.4
3.6
55.6
57.2
%
—
10
35
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
12
48
2.57
2.22
1.8
2.0
0.4
0.3
u/ml
—
6
24
16
74
2.24
2.19
1.6
1.6
—
—
—
0
0
7
19
3.75
2.16
1.1
1.2
—
—
—
0
0
8
25
3.27
2.11
1.3
1.3
—
—
—
0
0
115
929
1.42
2.07
3.5
2.5
160.0
107.1
ug/l
0.69
104
849
132
1095
1.41
2.03
4.1
3.6
0.0
0.0
estimate
0.00
29
201
9
32
2.87
2.02
1.3
1.3
—
—
nmol/l
—
0
0
17
84
2.09
2.00
1.3
1.5
—
—
—
0
0
96
762
1.41
1.87
3.3
3.0
—
—
—
0
0
92
726
1.41
1.85
2.2
2.4
58.5
55.5
u/l
0.43
84
673
241
2258
1.72
1.82
14.8
12.7
20.0
22.5
mg/l
0.60
197
1735
132
1114
1.37
1.75
4.2
3.6
0.0
0.0
estimate
0.00
31
194
122
1018
1.37
1.73
4.7
5.6
1.2
1.2
mmol/l
0.04
108
923
11
48
2.35
1.73
1.6
2.0
6017.0
677.1
u/l
—
6
17
59
436
1.45
1.69
1.8
1.4
—
—
—
0
0
130
1105
1.35
1.60
5.1
4.8
0.0
0.0
estimate
0.00
30
198
76
599
1.38
1.51
3.3
2.9
0.3
0.5
e6/l
0.32
56
438
90
735
1.34
1.42
2.5
3.1
62.8
29.7
u/l
0.63
83
699
19
112
1.75
1.39
2.9
3.2
5.5
5.1
kpa
0.29
12
106
102
851
1.32
1.38
4.6
3.6
—
—
—
0
0
17
97
1.80
1.38
4.4
2.3
12.4
14.2
nmol/l
0.50
17
92
91
749
1.33
1.35
2.8
3.3
2.3
2.4
mmol/l
0.50
80
651
58
447
1.38
1.31
1.5
1.7
496.7
461.0
pmol/l
0.36
48
365
167
1500
1.30
1.28
2.9
2.9
48.1
46.3
u/l
0.10
155
1409
53
404
1.39
1.28
3.0
2.7
2.4
2.5
mmol/l
0.86
48
351
36
256
1.47
1.26
6.4
7.2
104.8
104.2
mmol/l
0.41
36
249
6
25
2.43
1.25
1.0
1.5
—
—
—
0
0
38
274
1.45
1.24
2.9
2.1
26.6
22.7
%
1.07
30
234
50
381
1.38
1.21
1.5
1.5
—
—
—
0
0
6
26
2.34
1.19
1.2
1.5
0.2
0.5
nmol/l
—
6
20
67
539
1.32
1.15
2.6
2.6
6106.0
9182.4
umol/l
0.20
56
463
144
1282
1.27
1.13
4.1
4.8
6.7
6.6
mmol/l
0.11
137
1184
22
145
1.56
1.10
1.1
1.2
150.2
177.6
iu/ml
—
9
65
5
21
2.41
1.09
1.2
1.2
—
—
—
0
0
223
2107
1.36
1.06
6.3
5.5
38.8
39.3
mmol/mol
0.60
203
1962
44
337
1.37
1.04
3.2
3.6
0.8
0.8
mmol/l
0.10
39
309
9
48
1.91
1.01
1.0
1.3
—
—
—
0
0
136
1214
1.25
1.00
4.4
6.2
10.5
10.4
umol/l
0.10
127
1154
5
23
2.20
0.98
1.4
1.1
—
—
—
0
0
72
598
1.28
0.98
5.7
3.8
0.0
0.0
estimate
0.00
30
195
0
32
0.00
0.95
0.0
3.8
—
—
—
0
0
34
256
1.38
0.90
1.7
2.5
5.6
6.0
umol/l
0.10
28
224
224
2131
1.32
0.90
14.8
12.2
83.9
81.3
ml/min/173m2
1.18
191
1721
232
2221
1.35
0.86
5.1
4.5
5.8
5.9
mmol/l
0.43
217
2032
52
421
1.29
0.86
3.8
3.6
51.7
293.6
ng/l
1.83
42
323
60
495
1.27
0.86
1.4
1.5
22.3
21.6
nmol/l
0.12
51
416
8
47
1.72
0.81
1.0
1.7
—
—
—
0
0
16
106
1.54
0.81
10.3
9.7
24.3
24.9
mmol/l
0.34
16
98
14
90
1.59
0.80
1.8
1.4
—
—
—
0
0
215
2044
1.27
0.79
15.9
13.9
40.1
39.7
%
0.32
151
1489
60
504
1.25
0.75
1.8
1.6
0.8
1.0
mg/l
0.80
47
406
5
26
1.94
0.71
3.0
3.0
2.4
3.1
nmol/l
—
5
26
15
103
1.48
0.66
3.3
3.3
1.1
2.3
mmol/l
—
9
85
24
182
1.35
0.64
2.7
1.9
—
—
—
0
0
11
71
1.57
0.63
1.5
1.6
—
—
—
0
0
11
71
1.57
0.63
1.9
1.9
—
—
—
0
0
37
300
1.27
0.62
3.6
4.3
24.4
21.4
%
0.48
17
139
22
166
1.35
0.61
2.4
1.9
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
2.0
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
16
115
1.42
0.58
1.3
1.2
—
—
—
0
0
6
36
1.68
0.57
1.3
1.5
—
—
—
0
0
22
283
0.76
0.57
4.7
4.3
34.3
31.8
%
0.47
16
188
8
55
1.47
0.56
2.1
1.3
—
—
—
0
0
18
134
1.37
0.54
1.7
1.4
—
—
—
0
0
17
126
1.37
0.53
3.2
3.5
4.2
4.6
pmol/l
1.20
12
107
9
64
1.42
0.52
2.2
1.7
—
—
—
0
0
11
75
1.49
0.51
2.0
2.2
—
—
—
0
0
39
332
1.20
0.45
2.7
2.6
3.6
3.2
e6/l
0.07
23
157
5
31
1.62
0.43
1.4
1.1
—
—
—
0
0
5
31
1.62
0.43
2.8
3.8
15.4
108.6
u/ml
—
5
31
8
56
1.44
0.43
1.3
1.5
—
—
—
0
0
8
58
1.39
0.42
1.6
1.1
—
—
—
0
0
8
58
1.39
0.42
1.3
1.2
—
—
—
0
0
67
602
1.15
0.42
2.7
3.1
974.5
874.8
ng/l
0.07
54
503
5
33
1.52
0.41
1.0
1.8
—
—
—
0
0
5
33
1.52
0.41
2.0
1.4
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
235
2296
1.20
0.39
5.6
5.0
2.8
2.8
mmol/l
0.14
219
2120
19
152
1.27
0.38
1.4
1.3
—
40.9
—
0
12
146
1388
1.11
0.36
3.5
2.9
—
—
—
0
0
14
108
1.31
0.36
1.9
2.3
0.0
0.2
e6/l
2.21
14
102
31
265
1.19
0.35
6.5
6.5
—
—
—
0
0
44
389
1.16
0.34
1.5
1.6
1068.6
1249.9
nmol/l
0.65
30
288
42
370
1.16
0.34
2.7
2.5
0.8
1.1
e6/l
0.65
27
194
231
2259
1.17
0.34
5.3
4.4
4.7
4.8
mmol/l
0.34
216
2099
21
252
0.82
0.33
1.4
2.0
—
—
—
0
0
10
74
1.37
0.33
1.5
2.3
300.0
248.0
ug/l
—
10
69
27
230
1.19
0.32
2.0
3.0
1.1
0.7
ug/l
0.36
16
149
7
54
1.30
0.30
1.0
1.9
—
—
—
0
0
21
249
0.83
0.30
1.4
1.9
—
—
—
0
0
24
207
1.18
0.26
1.8
2.2
0.2
0.2
g/l
0.66
17
193
228
2240
1.13
0.24
5.0
4.4
1.5
1.5
mmol/l
0.72
213
2068
101
1061
0.92
0.23
4.4
3.8
—
—
—
0
0
5
40
1.25
0.22
1.0
1.5
—
—
—
0
0
5
41
1.22
0.22
1.8
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
53.2
—
0
5
0
10
0.00
0.21
0.0
2.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
4.4
—
0
5
0
10
0.00
0.21
0.0
2.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
22.6
—
0
10
19
219
0.86
0.21
4.1
3.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
5
43
1.17
0.21
2.8
1.5
0.6
0.8
nmol/l
—
5
33
10
80
1.26
0.21
2.2
1.8
—
—
—
0
0
220
2162
1.10
0.20
4.9
3.9
1.3
1.3
mmol/l
0.35
207
1981
6
48
1.26
0.20
1.2
4.9
—
4.3
—
0
5
6
49
1.23
0.20
1.0
1.9
—
—
—
0
0
6
49
1.23
0.20
5.0
1.7
—
—
—
0
0
6
50
1.20
0.20
1.2
1.2
—
—
—
0
0
27
247
1.10
0.14
6.6
9.4
0.0
1.4
mmol/l
1.45
22
202
8
98
0.81
0.14
3.0
2.9
57.1
48.7
%
—
8
98
14
125
1.13
0.10
1.6
1.4
—
—
—
0
0
51
533
0.95
0.10
2.7
2.1
—
—
—
0
0
5
60
0.83
0.08
1.2
1.2
—
—
—
0
0
5
64
0.78
0.08
1.6
1.8
—
—
—
0
0
7
64
1.10
0.08
2.4
2.2
83.4
94.0
%
—
7
59
69
669
1.04
0.08
1.8
1.6
1.3
1.4
mmol/l
0.52
62
567
7
67
1.05
0.08
1.0
1.1
—
—
—
0
0
7
67
1.05
0.08
1.0
1.1
—
—
—
0
0
17
181
0.94
0.05
7.4
2.9
-0.1
2.4
mmol/l
2.05
12
149
35
338
1.04
0.04
1.6
2.0
—
—
—
0
0
10
109
0.91
0.04
1.4
2.2
1.3
1.3
%
—
10
109
84
849
0.98
0.02
4.3
3.4
21.5
32.0
ng/l
0.70
52
571
12
127
0.94
0.01
1.7
1.9
—
—
—
0
0
19
191
0.99
0.00
9.2
6.4
1.2
1.3
mmol/l
0.34
19
182
22
217
1.02
0.00
1.7
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
5
56
0.89
0.00
1.6
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
8
79
1.01
0.00
1.4
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
8
86
0.93
0.00
13.4
3.3
22.4
25.1
mmol/l
—
8
79
0
5
0.00
0.00
0.0
1.0
—
96.2
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
82.8
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
110.7
—
0
7
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_HAIRLOSSSCAR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_HAIRLOSSSCAR | 1.016 [0.78, 1.33] | 0.91 |
| Birth year | 0.996 [0.99, 1.0] | 0.377 |
During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 867 females with L12_HAIRLOSSSCAR died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have L12_HAIRLOSSSCAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.114% | No data |
| 5 | 0.624% | No data |
| 10 | 1.506% | No data |
| 15 | 3.054% | No data |
| 20 | 5.469% | No data |
Relationships between endpoints
↥Index endpoint: L12_HAIRLOSSSCAR – Cicatricial alopecia [scarring hair loss]
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data