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FG R12 + FR

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Other and unspecified pemphigoid

DOID Endpoint Browser PheWeb

L12_PEMPHIGOID_NAS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L12.8, L12.9, L12.9+H13.3
  • Hospital discharge: ICD-9 — 6945
  • Hospital discharge: ICD-8 — 69402
  • Cause of death: ICD-10 — L12.8, L12.9, L12.9+H13.3
  • Cause of death: ICD-9 — 6945
  • Cause of death: ICD-8 — 69402
  • KELA reimbursements: KELA codes — ANY
  • KELA reimbursements: ICD-10 — L12

3 out of 7 registries used, show all original rules.

280

4. Check minimum number of events

None

280

5. Include endpoints

None

280

6. Filter based on genotype QC (FinnGen only)

280

Control definitions (FinnGen only)

Control exclude
L12_BULLOUS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF6

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2871 1684 1154
Only index persons 2032 1255 777
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.03
Only index persons 0.04 0.05 0.03
Median age at first event (years)
Whole population 75.93 76.22 75.54
Only index persons 75.51 76.02 74.67

-FinnGen-

Key figures

All Female Male
Number of individuals 280 158 122
Unadjusted period prevalence (%) 0.05 0.05 0.05
Median age at first event (years) 72.29 70.58 74.51

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
239
Matched controls
2392
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L12.9
ICD-10 Finland
Pemphigoid, unspecified
+∞
171.1
143
*
L12.0
ICD-10 Finland
Bullous pemphigoid
2669.9
146.9
127
*
L12.8
ICD-10 Finland
Other pemphigoid
+∞
89.3
80
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
14.0
55.8
106
128
D07AD01
ATC
clobetasol; topical
10.1
49.5
116
203
D07AC01
ATC
betamethasone; topical
7.8
47.1
164
522
H02AB06
ATC
prednisolone; systemic
8.8
46.4
197
829
135
Kela drug reimbursment
Pemphigus
+∞
45.3
42
*
L04AX01
ATC
azathioprine; systemic
23.5
40.0
58
32
J04BA02
ATC
dapsone; oral
92.0
29.6
32
*
L12.1
ICD-10 Finland
Cicatricial pemphigoid
+∞
27.6
26
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
5.4
25.0
89
237
E0000UV
ATC
NA
3.9
22.0
140
634
TQW80
NOMESCO Finland
Local dermatologic skincare
19.6
20.7
31
18
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
7.0
18.9
49
85
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.4
17.9
132
637
D07AC13
ATC
mometasone; topical
3.5
17.4
109
462
XQ848
NOMESCO Finland
Dermatological photography
19.3
17.4
26
15
ECA20
NOMESCO Finland
Biopsy of gingiva
26.7
16.3
22
9
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
16.3
15.7
25
17
EKA10
NOMESCO Finland
Biopsy of cheek
15.8
14.4
23
16
L13.9
ICD-10 Finland
Bullous disorder, unspecified
56.8
14.0
16
*
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
3.9
12.0
54
168
E000001
ATC
NA
3.2
11.6
73
292
H13.3*L12.9
ICD-10 Finland
Ocular pemphigoid
+∞
11.5
11
*
SBA00
NOMESCO Finland
Microbiological examinations
12.0
10.8
19
17
L12
ICD-10 Finland
Pemphigoid
114.8
10.5
11
*
S99
ICPC
Skin disease other
9.7
9.7
19
21
D07BC01
ATC
betamethasone and antiseptics; topical
3.5
9.6
48
162
D07AB02
ATC
hydrocortisone butyrate; topical
2.5
8.9
87
447
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
6.7
8.2
20
32
D07AB08
ATC
desonide; topical
3.2
8.0
42
147
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.0
7.9
48
185
K13.74
ICD-10 Finland
Lichen rubs planus in the mouth
19.1
7.7
11
6
K13.78
ICD-10 Finland
Other change in the oral mucosa
8.3
7.2
15
19
K12.10
ICD-10 Finland
Stomatitis NOS
20.8
7.2
10
5
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.6
7.1
56
253
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.5
7.0
58
269
L43.8
ICD-10 Finland
Other lichen planus
7.2
6.6
15
22
L12.2
ICD-10 Finland
Chronic bullous disease of childhood
+∞
6.3
6
*
L29.9
ICD-10 Finland
Pruritus, unspecified
6.3
6.1
15
25
R06AE07
ATC
cetirizine; oral
2.0
6.1
102
644
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.3
6.1
66
346

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
110
19
94.71
204.80
1.7
1.3
590.0
—
titre
—
37
0
70
99
9.09
49.48
1.5
1.2
—
—
—
0
0
214
1125
4.83
30.40
12.1
5.4
1.7
1.8
e9/l
0.16
191
987
212
1111
4.74
30.14
12.0
5.4
0.0
0.0
e9/l
0.59
190
953
211
1104
4.70
30.01
12.0
5.4
0.6
0.6
e9/l
0.75
189
943
213
1148
4.57
28.41
12.3
5.6
0.2
0.2
e9/l
2.98
193
998
164
744
3.91
28.04
12.2
5.3
—
—
—
0
0
199
1037
4.18
27.49
12.8
5.5
59.3
58.6
%
0.33
189
956
194
997
4.08
27.27
12.9
5.5
0.7
0.6
%
0.26
185
913
199
1045
4.13
26.99
13.5
5.7
25.4
26.0
%
0.34
188
955
197
1028
4.09
26.95
13.0
5.5
3.1
2.8
%
1.13
188
944
197
1032
4.07
26.70
13.5
5.8
9.1
8.8
%
0.78
187
952
221
1300
4.32
24.19
14.1
9.1
4.3
4.2
e9/l
0.19
200
1134
71
225
3.89
19.73
2.3
1.8
353.8
377.2
nmol/l
0.36
66
201
71
269
3.20
14.62
2.0
1.4
—
—
—
0
0
130
728
2.47
12.22
4.5
4.2
—
—
—
0
0
62
244
2.98
11.77
1.5
1.3
970.9
570.7
titre
0.37
11
60
232
1783
2.76
9.72
10.1
7.4
82.7
80.5
u/l
0.28
219
1649
55
233
2.69
8.96
3.8
2.6
82.2
68.7
e9/l
1.66
44
181
181
1272
2.20
8.92
6.0
5.9
10.4
11.9
umol/l
1.69
170
1192
113
668
2.16
8.65
3.0
2.1
3.3
3.4
mg/l
0.16
99
560
144
937
2.11
8.54
3.4
2.7
144.1
133.6
ug/l
0.26
132
839
59
267
2.53
8.39
2.9
1.7
—
—
—
0
0
215
1666
2.25
7.65
5.7
4.3
16.2
14.0
mm/h
1.07
203
1510
82
445
2.19
7.65
7.6
4.9
—
—
—
0
0
47
200
2.62
7.54
1.3
2.5
—
—
—
0
0
189
1411
2.04
7.18
5.3
4.7
7.3
6.8
mmol/l
1.16
181
1321
49
218
2.51
7.17
1.6
3.1
65.6
66.5
g/l
0.37
44
196
170
1240
1.94
6.70
8.0
6.1
1.2
1.2
mmol/l
0.08
137
1037
38
161
2.57
6.13
5.6
3.9
0.3
0.4
%
0.16
11
42
156
1131
1.86
6.00
4.2
4.1
0.0
0.0
estimate
0.00
22
205
158
1151
1.86
5.98
4.3
4.2
0.0
0.0
estimate
0.00
22
196
151
1088
1.84
5.89
5.7
4.2
33.9
35.0
g/l
1.54
139
1005
41
184
2.44
5.86
5.4
4.0
0.5
0.8
%
0.50
18
58
60
319
2.12
5.75
6.6
4.4
1.1
1.0
mmol/l
0.67
55
291
39
173
2.46
5.71
4.8
4.1
0.0
0.1
%
1.49
17
52
111
736
1.84
5.59
2.9
2.3
60.9
57.7
u/l
0.29
97
674
144
1046
1.78
5.26
13.0
10.1
1.3
1.3
inr
0.02
40
281
198
1583
1.86
5.20
6.5
5.1
5763.9
3855.6
e6/l
—
7
37
199
1595
1.86
5.17
5.8
4.6
—
—
—
0
0
91
579
1.85
5.16
9.6
6.9
—
—
—
0
0
19
60
3.32
5.14
1.2
1.2
—
3.0
—
0
6
153
1143
1.75
4.97
6.7
5.6
1.2
1.2
mmol/l
0.41
130
1030
85
535
1.85
4.96
2.1
1.8
101408857.7
434.6
pmol/l
0.49
71
433
82
512
1.85
4.90
4.9
4.7
1.0
1.0
kg/l
0.41
14
70
97
640
1.79
4.83
1.8
1.7
20.2
21.1
nmol/l
0.22
85
526
152
1140
1.73
4.82
5.9
5.5
0.0
0.0
estimate
0.00
25
201
117
816
1.75
4.81
3.8
3.5
—
—
—
0
0
87
557
1.82
4.78
1.8
1.7
1225.5
1165.1
nmol/l
0.27
73
410
126
900
1.73
4.74
2.5
2.2
—
—
—
0
0
62
365
1.90
4.41
2.8
1.9
—
—
—
0
0
256
2279
2.44
4.41
20.0
11.0
23.7
24.1
u/l
0.22
250
2190
11
26
4.36
4.39
1.3
1.2
—
—
—
0
0
29
129
2.39
4.23
2.5
2.6
—
—
—
0
0
82
540
1.73
4.01
4.6
4.1
—
—
—
0
0
64
392
1.82
4.00
1.7
1.5
2.9
2.7
g/l
0.25
45
227
254
2275
2.25
3.94
29.5
19.7
139.1
139.5
mmol/l
1.79
245
2214
138
1046
1.63
3.92
2.4
2.1
91.6
92.6
pmol/l
0.09
82
533
246
2181
2.05
3.86
27.4
16.6
24.9
26.0
mg/l
0.25
221
1767
254
2279
2.23
3.86
29.8
19.8
4.0
4.0
mmol/l
0.13
245
2218
60
369
1.80
3.69
3.8
2.2
22.1
21.8
%
0.06
47
323
63
394
1.77
3.66
2.7
3.0
0.8
0.8
mmol/l
0.07
54
361
69
444
1.74
3.63
1.3
1.2
1.8
1.3
u/ml
0.20
20
107
240
2126
1.90
3.54
5.7
5.1
6.2
6.1
mmol/l
0.18
225
1899
71
471
1.68
3.32
5.9
3.8
47.8
169.6
ng/l
1.66
60
401
257
2343
2.18
3.30
42.4
24.5
91.9
91.6
fl
0.54
252
2307
257
2343
2.18
3.30
42.6
24.6
245.1
243.1
e9/l
0.17
251
2279
36
194
1.98
3.30
1.7
1.4
—
—
—
0
0
257
2344
2.17
3.28
42.7
24.6
7.5
6.8
e9/l
2.66
252
2269
257
2344
2.17
3.28
43.1
24.7
129.6
132.4
g/l
2.12
252
2304
257
2344
2.17
3.28
42.3
24.5
30.4
30.4
pg
0.09
252
2308
257
2344
2.17
3.28
42.5
24.6
4.3
4.4
e12/l
1.69
251
2268
125
959
1.55
3.18
17.6
10.3
0.0
0.0
e9/l
1.29
99
787
16
62
2.68
3.10
1.3
1.6
—
—
—
0
0
116
887
1.53
2.94
4.4
4.0
—
—
—
0
0
31
166
1.98
2.90
5.9
4.2
0.0
0.2
%
—
10
48
104
779
1.53
2.89
6.5
3.9
7.4
7.4
ph
0.02
15
143
44
265
1.78
2.88
2.3
2.9
5.4
10.1
umol/l
1.76
38
232
56
363
1.68
2.84
37.2
27.2
1.8
1.3
inr
—
8
39
47
291
1.74
2.81
3.8
6.4
1.2
1.4
mmol/l
0.11
33
230
37
213
1.85
2.80
5.2
3.8
—
—
—
0
0
227
2019
1.66
2.78
5.4
4.8
2.1
2.0
mu/l
0.60
206
1787
8
19
4.30
2.70
1.5
1.3
—
—
—
0
0
9
24
3.84
2.69
1.2
1.2
—
—
—
0
0
230
2059
1.66
2.67
8.1
6.5
42.5
40.9
mmol/mol
1.32
214
1895
49
314
1.68
2.59
1.3
1.2
—
—
—
0
0
244
2226
1.75
2.54
26.1
15.6
—
—
—
0
0
27
145
1.95
2.52
1.2
1.2
—
—
—
0
0
233
2102
1.65
2.51
4.8
4.7
4.4
4.5
mmol/l
0.62
219
1905
27
146
1.94
2.47
6.6
2.4
4.4
4.0
e9/l
0.36
21
100
97
736
1.49
2.47
2.9
2.6
—
—
—
0
0
82
601
1.52
2.47
3.3
2.9
13319.2
7365.1
umol/l
0.35
77
495
36
215
1.77
2.44
1.4
1.5
—
—
—
0
0
18
84
2.22
2.40
6.8
2.8
0.3
0.2
g/l
0.45
13
25
190
1647
1.48
2.39
4.5
3.9
15.1
15.0
pmol/l
0.21
175
1449
130
1051
1.44
2.36
4.7
4.0
—
—
—
0
0
42
265
1.69
2.35
2.1
2.8
4.8
6.1
ug/l
0.37
33
232
109
856
1.45
2.30
3.2
3.2
2.3
2.4
mmol/l
1.62
90
740
84
627
1.49
2.30
4.6
4.6
0.0
0.0
estimate
0.00
23
201
237
2162
1.63
2.27
5.2
5.3
2.5
2.6
mmol/l
0.37
219
1947
99
767
1.45
2.23
4.4
3.8
16.1
8.0
mg/mmol
0.86
71
466
5
9
5.63
2.22
3.2
2.8
—
—
—
0
0
208
1852
1.48
2.15
30.4
18.2
37.4
38.8
%
0.88
126
1197
22
117
1.96
2.13
5.3
3.0
—
—
—
0
0
9
31
2.96
2.09
1.3
1.1
—
—
—
0
0
127
1040
1.40
2.08
5.0
4.3
451.5
44.6
ng/l
0.50
102
807
93
724
1.43
2.02
3.8
3.0
707.6
225.3
mg/l
0.34
70
456
37
237
1.65
1.97
1.7
1.7
—
—
—
0
0
5
11
4.61
1.95
4.2
1.9
—
—
—
0
0
22
121
1.89
1.95
1.2
1.3
—
—
—
0
0
37
238
1.64
1.94
4.6
3.5
—
—
—
0
0
7
22
3.24
1.89
1.0
1.1
—
—
—
0
0
97
771
1.39
1.85
2.7
2.0
154.7
198.9
u/l
0.64
92
718
6
17
3.58
1.84
1.0
1.1
—
—
—
0
0
9
35
2.62
1.81
1.1
1.3
—
—
—
0
0
227
2080
1.48
1.81
4.7
4.7
1.4
1.5
mmol/l
1.56
211
1863
8
29
2.81
1.80
1.0
1.1
—
—
—
0
0
5
13
3.89
1.72
2.4
1.4
18.7
6.4
umol/l
—
5
7
109
894
1.36
1.69
4.7
4.0
128.5
83.5
e6/l
0.59
74
648
21
120
1.81
1.67
5.2
7.9
—
—
—
0
0
8
31
2.63
1.67
4.1
3.5
—
—
—
0
0
219
2006
1.42
1.64
4.4
4.2
1.3
1.3
mmol/l
0.78
204
1783
13
63
2.12
1.62
1.7
1.4
304.7
291.0
ug/g
—
6
31
5
14
3.62
1.62
1.4
1.6
—
—
—
0
0
92
740
1.36
1.60
4.2
2.9
6.5
6.9
mmol/l
0.42
79
606
38
260
1.53
1.56
1.4
1.2
—
—
—
0
0
78
613
1.38
1.56
3.4
3.8
—
—
—
0
0
28
178
1.64
1.56
3.4
3.0
—
—
—
0
0
35
236
1.55
1.54
4.7
3.5
5.7
5.8
kpa
0.27
35
229
6
21
2.90
1.51
1.3
1.4
—
—
—
0
0
9
40
2.29
1.41
1.3
1.6
54.6
61.4
%
—
9
40
6
24
2.53
1.31
2.7
3.2
—
—
—
0
0
9
45
2.03
1.24
1.3
1.3
—
—
—
0
0
46
344
1.40
1.23
1.5
1.3
19.3
34.4
iu/ml
1.63
17
112
5
19
2.66
1.22
1.2
1.0
—
—
—
0
0
39
284
1.43
1.21
1.3
1.3
—
—
—
0
0
93
778
1.29
1.20
3.9
3.4
1106.4
134.4
e6/l
0.45
71
602
6
26
2.34
1.19
1.5
1.2
—
—
—
0
0
16
95
1.73
1.16
1.9
2.1
—
—
—
0
0
5
20
2.53
1.15
1.4
1.6
—
—
—
0
0
5
20
2.53
1.15
1.2
1.2
—
—
—
0
0
19
119
1.64
1.15
4.9
3.6
22.9
24.2
mmol/l
0.71
19
109
7
30
2.37
1.13
1.4
1.4
—
—
—
0
0
29
204
1.47
1.08
5.2
7.5
—
—
—
0
0
14
82
1.74
1.07
3.1
3.6
—
—
—
0
0
43
327
1.37
1.06
1.4
1.3
8.4
13.5
u/ml
0.26
15
123
11
61
1.84
1.00
2.4
2.1
7.3
7.7
kpa
0.28
11
53
9
49
1.86
0.99
2.6
1.9
—
—
—
0
0
25
174
1.48
0.99
3.6
3.9
—
—
—
0
0
175
1604
1.24
0.98
4.3
4.2
—
—
—
0
0
33
244
1.40
0.96
4.8
3.9
—
—
—
0
0
21
142
1.52
0.95
3.6
4.1
—
—
—
0
0
7
37
1.91
0.94
4.6
2.4
4.9
5.2
e9/l
—
7
37
30
223
1.39
0.86
3.4
2.1
226.7
156.4
ug/g
0.44
24
170
18
121
1.52
0.85
1.1
1.4
—
44.0
—
0
8
6
31
1.96
0.85
1.5
1.4
—
—
—
0
0
17
114
1.52
0.81
2.2
3.0
—
—
—
0
0
10
58
1.75
0.80
2.1
2.5
—
—
—
0
0
6
33
1.84
0.79
3.0
11.0
8.8
6.8
mmol/l
—
6
27
0
26
0.00
0.79
0.0
3.7
—
—
—
0
0
20
141
1.45
0.77
6.5
5.5
25.2
24.7
mmol/l
0.25
20
141
10
59
1.72
0.77
1.8
3.0
136.0
61.6
ug/min
—
5
37
5
24
2.10
0.75
1.0
1.5
—
—
—
0
0
5
24
2.10
0.75
1.0
1.5
—
—
—
0
0
5
24
2.10
0.75
1.0
1.5
—
—
—
0
0
5
24
2.10
0.75
1.0
1.5
—
—
—
0
0
7
38
1.86
0.74
1.0
1.2
—
—
—
0
0
5
25
2.02
0.73
1.4
1.3
—
—
—
0
0
7
39
1.81
0.73
4.6
3.0
60.9
59.4
%
—
7
39
5
26
1.94
0.71
1.2
2.7
—
—
—
0
0
18
129
1.42
0.65
1.2
1.2
—
—
—
0
0
65
559
1.21
0.65
3.1
2.7
5.4
5.0
e6/l
0.17
58
495
84
742
1.19
0.63
5.3
5.5
15.3
2.4
ug/l
0.52
78
652
58
495
1.22
0.62
1.7
1.7
1.4
1.5
mg/l
0.11
49
387
8
50
1.62
0.62
7.5
2.8
—
—
—
0
0
10
64
1.58
0.59
1.3
4.9
—
—
—
0
0
6
36
1.68
0.57
3.8
1.1
—
—
—
0
0
6
37
1.63
0.56
3.8
3.4
—
—
—
0
0
15
108
1.41
0.54
1.4
1.3
—
—
—
0
0
6
40
1.51
0.52
1.2
1.4
—
—
—
0
0
24
189
1.30
0.51
1.3
1.6
—
—
—
0
0
17
128
1.35
0.49
1.3
1.3
—
—
—
0
0
7
46
1.53
0.48
1.1
1.7
—
—
—
0
0
13
95
1.39
0.44
1.1
1.6
—
—
—
0
0
7
51
1.38
0.44
1.0
1.1
—
—
—
0
0
8
56
1.44
0.43
1.0
1.1
—
—
—
0
0
8
56
1.44
0.43
2.6
2.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
17
134
1.29
0.38
2.0
2.4
1.0
1.2
%
0.61
17
134
10
72
1.40
0.37
1.9
1.6
—
—
—
0
0
7
57
1.23
0.29
1.6
1.3
—
—
—
0
0
58
534
1.11
0.25
3.4
2.9
486.2
554.6
mosm/kgh2o
2.32
47
446
5
38
1.32
0.23
3.4
2.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
5
43
1.17
0.21
1.0
1.1
19.6
56.0
u/l
—
5
37
0
13
0.00
0.21
0.0
2.8
—
—
—
0
0
33
298
1.12
0.20
4.1
4.2
5.1
44.5
ug/l
0.89
26
255
76
719
1.08
0.19
4.0
3.3
0.3
0.4
e6/l
0.36
57
541
6
78
0.76
0.16
1.2
1.2
—
—
—
0
0
9
83
1.09
0.15
5.7
5.0
—
—
—
0
0
9
107
0.84
0.13
2.6
4.1
—
—
—
0
0
39
415
0.93
0.12
2.4
3.2
1.6
0.8
ug/l
0.37
31
286
5
46
1.09
0.09
1.0
1.5
—
7.1
—
0
15
5
47
1.06
0.09
3.6
2.3
—
—
—
0
0
13
116
1.13
0.09
4.8
3.1
26.5
44.9
u/ml
0.72
13
111
6
55
1.09
0.09
11.3
2.9
5.0
5.0
kpa
—
6
55
6
55
1.09
0.09
11.3
2.9
8.4
7.9
kpa
—
6
55
8
74
1.08
0.07
11.4
11.5
—
—
—
0
0
7
83
0.84
0.07
1.3
1.3
—
—
—
0
0
71
691
1.04
0.07
4.1
3.3
—
—
—
0
0
51
527
0.96
0.06
1.3
1.3
—
—
—
0
0
50
514
0.97
0.05
3.3
3.0
2.5
2.5
mmol/l
0.18
44
452
18
171
1.06
0.03
1.7
1.5
—
—
—
0
0
19
182
1.05
0.02
3.1
4.3
—
—
—
0
0
59
592
1.00
0.00
1.8
1.6
1.3
1.3
mmol/l
0.15
54
487
75
752
1.00
0.00
5.1
4.4
—
—
—
0
0
65
647
1.01
0.00
3.0
3.2
—
—
—
0
0
22
216
1.02
0.00
1.4
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
39.4
—
0
5
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
3.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
7.4
—
0
8
0
9
0.00
0.00
0.0
6.2
—
48.2
—
0
9
0
7
0.00
0.00
0.0
8.7
—
1219.4
—
0
7
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
18.1
—
0
6
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
16
160
1.00
0.00
1.3
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
12.1
—
2331.9
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint L12_PEMPHIGOID_NAS and mortality.

Females

Parameter HR [95% CI] p-value
L12_PEMPHIGOID_NAS 1.903 [1.56, 2.32] < 0.001
Birth year 0.991 [0.98, 1.0] 0.044

During the follow-up period (1.1.1998 — 31.12.2019), 546 out of 1148 females with L12_PEMPHIGOID_NAS died.

Males

Parameter HR [95% CI] p-value
L12_PEMPHIGOID_NAS 2.036 [1.5, 2.76] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 407 out of 732 males with L12_PEMPHIGOID_NAS died.

Mortality risk

Mortality risk for people of age

years, who have L12_PEMPHIGOID_NAS.

N-year risk Females Males
1 0.148% 0.367%
5 1.004% 2.224%
10 2.413% 5.341%
15 4.364% 10.53%
20 7.81% 17.358%

Relationships between endpoints

↥

Index endpoint: L12_PEMPHIGOID_NAS – Other and unspecified pemphigoid

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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