bullous pemphigoid: Bullous pemphigoid (BP) is the most common form of autoimmune bullous dermatosis.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
311 |
4. Check minimum number of eventsNone |
311 |
5. Include endpointsNone |
311 |
6. Filter based on genotype QC (FinnGen only) |
304 |
Control definitions (FinnGen only)
- Control exclude
- L12_BULLOUS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF6
Similar endpoints
↥List of similar endpoints to
Other and unspecified pemphigoid
based on the number of shared cases.
Similar with more cases:
- Pemphigoid
- Bullous disorders
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Diseases of the skin and subcutaneous tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2871 | 1684 | 1154 |
| Only index persons | 2032 | 1255 | 777 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.03 |
| Only index persons | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 75.93 | 76.22 | 75.54 |
| Only index persons | 75.51 | 76.02 | 74.67 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 304 | 168 | 136 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | 72.74 | 70.89 | 75.02 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 311
- Matched controls
- 3110
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L12.9
ICD-10 Finland
Pemphigoid, unspecified
2482.8
228.3
193
*
L12.0
ICD-10 Finland
Bullous pemphigoid
3569.1
194.1
167
*
L12.8
ICD-10 Finland
Other pemphigoid
+∞
119.7
107
*
D07AD01
ATC
clobetasol; topical
11.5
107.1
168
288
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
12.4
105.2
139
191
L04AX01
ATC
azathioprine; systemic
18.5
82.0
71
49
D07AC01
ATC
betamethasone; topical
6.6
58.0
214
778
TQW80
NOMESCO Finland
Local dermatologic skincare
16.5
53.9
48
34
135
Kela drug reimbursment
Pemphigus
+∞
53.7
50
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
5.9
50.6
130
337
H02AB06
ATC
prednisolone; systemic
7.1
49.5
250
1141
J04BA02
ATC
dapsone; oral
183.8
46.2
47
*
XQ848
NOMESCO Finland
Dermatological photography
12.6
41.6
43
39
L04AX03
ATC
methotrexate; systemic
6.3
39.3
78
156
E0000UV, ,
ATC
4.5
36.4
201
903
L12.1
ICD-10 Finland
Cicatricial pemphigoid
+∞
30.7
29
*
D07AC13
ATC
mometasone; topical
3.7
27.9
143
585
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
10.0
26.0
31
34
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
9.8
22.4
27
30
EKA10
NOMESCO Finland
iopsy of buccal mucosa
9.8
22.4
27
30
ECA20
NOMESCO Finland
Biopsy of gingiva
42.0
22.1
27
7
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.1
21.3
176
921
L13.9
ICD-10 Finland
Bullous disorder, unspecified
112.2
19.8
21
*
S99
ICPC
Skin disease other
9.0
19.5
25
30
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
3.7
18.7
70
226
L29.9
ICD-10 Finland
Pruritus, unspecified
7.9
17.6
25
34
D07BC01
ATC
betamethasone and antiseptics; topical
3.7
16.9
63
202
E000001, ,
ATC
3.1
16.8
89
355
SBA00
NOMESCO Finland
Microbiological examinations
11.2
14.0
26
25
H13.3*L12.9
ICD-10 Finland
Ocular pemphigoid
+∞
13.6
13
*
L12
ICD-10 Finland
Pemphigoid
146.1
13.6
14
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.1
13.0
64
242
D07AB02
ATC
hydrocortisone butyrate; topical
2.5
12.9
119
620
K13.78
ICD-10 Finland
Other change in the oral mucosa
10.3
12.5
24
25
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.6
12.2
43
132
D07AB08
ATC
desonide; topical
3.1
11.4
54
199
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.4
10.7
97
495
A02BC02
ATC
pantoprazole; systemic
2.3
9.7
233
1743
A10AB05
ATC
insulin aspart; parenteral
3.1
9.6
44
158
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.2
9.5
118
682
S29
ICPC
Skin symptom/complaint other
2.4
9.4
77
373
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.5
9.1
70
329
L04AA06
ATC
mycophenolic acid; systemic
10.5
8.6
16
16
A46
ICD-10 Finland
Erysipelas
2.4
8.4
66
313
R06AX27
ATC
desloratadine; oral
2.3
8.3
78
399
L29.8
ICD-10 Finland
Other pruritus
15.0
8.3
13
9
L43.8
ICD-10 Finland
Other lichen planus
8.5
8.2
17
21
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.1
8.1
99
562
J01DB01
ATC
cefalexin; oral
2.4
8.0
260
2104
XQ802
NOMESCO Finland
Epicutan test
4.6
8.0
19
43
EBA15
NOMESCO Finland
Extraction of multiple teeth
4.4
7.9
20
48
SPAT1167
SPAT
Insertion of urinary catheter
4.1
7.8
22
57
A28
ICPC
Limited function/disability NOS
2.1
7.7
89
495
K12.10
ICD-10 Finland
Stomatitis NOS
18.9
7.7
11
6
SPAT1262
SPAT
Handing over of treatment supplies
2.2
7.7
75
390
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.9
7.6
23
63
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.9
7.5
22
59
J01FF01
ATC
clindamycin; systemic
2.1
7.5
96
554
L30.0
ICD-10 Finland
Nummular dermatitis
4.2
7.5
20
50
L28.1
ICD-10 Finland
Prurigo nodularis
13.8
7.4
12
9
SAA04
NOMESCO Finland
Special examination of mouth
3.6
7.1
24
71
K13.74
ICD-10 Finland
Lichen rubs planus in the mouth
9.1
7.1
14
16
A10AE04
ATC
insulin glargine; parenteral
2.5
6.8
45
196
R06AE07
ATC
cetirizine; oral
1.9
6.7
130
859
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.0
6.7
87
502
SPAT1285
SPAT
Provision of consultation response
3.3
6.6
25
80
EBA10
NOMESCO Finland
Operative extraction of tooth
2.9
6.6
31
113
SPAT1153
SPAT
Removal of sutures
1.9
6.6
119
768
D09AB01
ATC
zinc bandage without supplements; topical
6.4
6.6
16
26
S18
ICPC
Laceration/cut
1.8
6.3
157
1115
K12.18
ICD-10 Finland
Other forms of stomatitis
18.5
6.3
9
5
L51.19
ICD-10 Finland
Other bullous erythema multiforme
+∞
6.3
6
*
L10.9
ICD-10 Finland
Pemphigus, unspecified
+∞
6.3
6
*
L12.2
ICD-10 Finland
Chronic bullous disease of childhood
+∞
6.3
6
*
TDM10
NOMESCO Finland
Puncture of maxillary antrum
4.1
6.3
17
43
WZC00
NOMESCO Finland
Treatment plan or consultation
1.9
6.2
111
711
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
6.1
105
662
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.0
6.1
83
484
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
173
17
228.09
307.65
3.0
1.2
28.78
—
u/ml
—
94
0
121
19
103.60
228.90
1.7
1.3
510.91
—
titre
—
44
0
221
1152
4.17
30.43
12.4
5.5
3.11
2.82
%
1.04
211
1063
223
1171
4.20
30.34
12.9
5.8
25.21
25.91
%
0.43
212
1084
222
1163
4.18
30.29
12.3
5.5
59.26
58.72
%
0.29
212
1078
245
1449
4.26
26.30
13.6
9.0
4.35
4.24
e9/l
0.32
221
1266
82
249
4.11
24.34
2.4
1.8
353.52
379.04
nmol/l
0.46
75
224
25
31
8.68
19.03
1.7
1.3
—
—
—
0
0
129
744
2.25
10.69
3.0
2.1
3.19
3.32
mg/l
0.24
113
626
164
1045
2.20
10.58
3.4
2.7
141.75
138.29
ug/l
0.08
149
936
257
1978
2.72
10.57
10.1
7.5
81.81
80.85
u/l
0.12
244
1832
200
1399
2.20
9.96
6.1
6.0
10.46
11.94
umol/l
1.89
189
1309
241
1851
2.34
9.08
5.8
4.3
16.19
14.13
mm/h
1.04
228
1679
211
1564
2.09
8.30
5.3
4.7
7.32
6.84
mmol/l
1.41
203
1460
56
250
2.51
8.10
1.5
3.1
65.26
66.17
g/l
0.43
50
224
191
1384
1.98
7.78
7.7
6.4
1.22
1.22
mmol/l
0.03
155
1167
187
1367
1.92
7.18
23.1
17.6
1.37
1.36
inr
0.06
53
373
115
719
1.95
7.07
1.7
1.6
20.60
21.06
nmol/l
0.10
99
594
64
322
2.24
7.03
3.0
4.2
232.29
242.10
u/l
0.46
59
300
125
819
1.88
6.58
3.1
2.3
59.50
63.05
u/l
0.21
112
754
169
1220
1.84
6.50
5.6
4.3
33.99
35.00
g/l
1.59
157
1126
83
481
1.99
6.25
3.4
2.2
12.69
12.37
umol/l
0.16
78
437
184
1396
1.78
5.70
4.4
3.1
63.85
51.99
u/l
0.89
172
1272
287
2531
2.74
5.65
19.7
11.1
23.77
24.03
u/l
0.12
281
2430
12
17
7.29
5.49
1.3
1.2
—
—
—
0
0
98
624
1.83
5.47
1.9
1.7
1191.75
1183.35
nmol/l
0.03
80
457
219
1763
1.82
5.41
6.5
5.0
5763.86
4014.16
e6/l
—
7
44
170
1274
1.74
5.38
6.5
5.6
1.21
1.21
mmol/l
0.52
147
1150
80
483
1.88
5.25
1.3
1.2
1.63
1.22
u/ml
0.19
24
119
146
1056
1.72
5.19
2.8
2.3
82.25
77.63
nmol/l
0.79
132
912
159
1178
1.72
5.18
2.5
2.1
93.20
93.19
pmol/l
0.00
92
607
64
360
1.98
5.18
6.3
4.6
1.07
1.02
mmol/l
0.51
59
329
30
123
2.59
5.14
1.4
2.6
—
—
—
0
0
21
71
3.10
5.09
1.4
1.5
2.02
0.06
iu/ml
—
5
19
285
2531
2.51
5.05
29.7
19.9
138.93
139.60
mmol/l
3.20
276
2461
79
483
1.85
4.96
2.2
1.9
—
—
—
0
0
285
2536
2.48
4.94
29.9
20.0
3.99
4.00
mmol/l
0.13
276
2465
276
2424
2.23
4.93
27.4
16.8
24.77
26.04
mg/l
0.31
249
1965
271
2367
2.13
4.85
5.8
5.1
6.12
6.10
mmol/l
0.08
253
2116
169
1288
1.68
4.84
4.4
4.2
0.00
0.00
estimate
-0.00
25
220
8
7
11.69
4.81
2.4
1.0
8.87
10.29
ug/l
—
8
7
25
99
2.66
4.59
1.8
1.6
—
—
—
0
0
166
1273
1.65
4.53
4.3
4.2
0.00
0.00
estimate
-0.00
30
247
15
44
3.53
4.52
1.1
1.2
—
—
—
0
0
69
417
1.84
4.46
3.4
2.3
23.19
21.97
%
0.26
53
360
132
959
1.65
4.43
3.1
3.3
2266.88
1735.86
ng/l
0.45
115
828
72
442
1.82
4.43
2.6
3.2
0.80
0.82
mmol/l
0.45
62
410
259
2249
1.91
4.39
5.6
4.8
2.10
2.00
mu/l
0.56
234
1995
20
72
2.90
4.37
1.5
1.3
—
—
—
0
0
52
288
1.97
4.37
2.3
2.8
5.36
10.18
umol/l
2.10
44
254
92
611
1.72
4.31
2.1
1.8
96000404.89
11469243.73
pmol/l
0.41
75
497
158
1212
1.62
4.20
2.8
2.5
—
—
—
0
0
26
110
2.49
4.20
2.2
1.7
—
—
—
0
0
288
2608
2.41
4.19
41.5
24.8
38.40
39.31
%
1.27
257
2423
288
2608
2.41
4.19
42.1
24.8
243.36
242.36
e9/l
0.09
282
2535
288
2609
2.40
4.17
42.0
24.8
4.31
4.39
e12/l
2.01
282
2523
288
2609
2.40
4.17
42.6
24.9
129.68
132.45
g/l
2.30
283
2564
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
22
86
2.68
4.15
2.3
2.4
0.43
0.39
u/ml
0.18
12
45
9
14
6.58
4.01
1.1
1.1
—
—
—
0
0
162
1280
1.55
3.60
6.1
5.7
0.00
0.00
estimate
-0.00
28
224
263
2341
1.80
3.49
4.8
4.7
4.42
4.48
mmol/l
0.41
244
2129
258
2284
1.76
3.49
8.2
6.5
42.48
41.00
mmol/mol
1.32
240
2102
24
107
2.35
3.48
1.4
2.9
0.12
0.74
g/l
1.34
19
95
39
212
1.96
3.46
1.7
1.6
—
—
—
0
0
216
1834
1.58
3.39
4.7
3.9
15.16
15.04
pmol/l
0.26
197
1608
16
59
2.80
3.37
1.1
1.2
—
—
—
0
0
85
587
1.62
3.34
4.8
4.7
1.01
1.02
kg/l
0.49
14
81
126
957
1.53
3.26
3.0
3.2
2.33
2.35
mmol/l
1.32
106
834
31
161
2.03
3.13
5.1
3.7
1.87
2.24
mmol/l
0.21
25
122
267
2407
1.77
3.12
5.2
5.3
2.53
2.58
mmol/l
0.31
244
2175
77
527
1.61
3.12
5.9
4.0
45.21
156.79
ng/l
1.73
66
451
8
16
5.10
3.07
1.9
1.3
12.96
5.48
umol/l
—
8
9
115
866
1.52
3.06
4.1
3.6
14.68
8.45
mg/mmol
0.72
83
529
33
180
1.93
2.91
1.6
1.8
—
—
—
0
0
25
123
2.12
2.91
2.2
1.8
2.83
4.54
ug/l
0.22
20
101
93
676
1.54
2.89
3.1
2.8
11827.56
6499.44
umol/l
0.36
87
565
144
1161
1.45
2.63
2.9
2.7
—
—
—
0
0
110
846
1.46
2.56
2.7
2.1
161.59
202.72
u/l
0.63
104
786
256
2317
1.59
2.53
4.7
4.6
1.42
1.47
mmol/l
1.28
235
2083
248
2229
1.56
2.53
4.3
4.2
1.32
1.26
mmol/l
0.65
228
1988
143
1160
1.43
2.49
5.3
4.3
393.14
42.94
ng/l
0.50
118
903
84
617
1.50
2.45
2.5
2.6
—
—
—
0
0
124
987
1.43
2.37
4.7
4.5
—
—
—
0
0
49
326
1.60
2.22
4.0
6.4
1.43
1.34
mmol/l
0.07
35
258
51
344
1.58
2.18
2.3
1.8
—
—
—
0
0
51
345
1.57
2.15
2.2
1.9
—
—
—
0
0
91
703
1.42
2.01
4.5
4.5
0.00
0.00
estimate
-0.00
26
222
19
99
1.98
1.95
2.4
3.0
—
—
—
0
0
6
16
3.80
1.94
1.0
1.2
—
—
—
0
0
30
183
1.71
1.90
1.9
1.4
—
—
—
0
0
124
1018
1.36
1.88
3.9
3.3
—
—
—
0
0
8
28
2.90
1.87
1.0
1.7
—
—
—
0
0
6
17
3.58
1.84
1.8
2.2
—
—
—
0
0
7
23
3.09
1.81
1.0
1.1
—
—
—
0
0
7
23
3.09
1.81
1.0
1.1
—
—
—
0
0
7
23
3.09
1.81
1.0
1.1
—
—
—
0
0
7
23
3.09
1.81
1.0
1.1
—
—
—
0
0
7
23
3.09
1.81
1.0
1.1
—
—
—
0
0
7
23
3.09
1.81
1.0
1.1
—
—
—
0
0
43
293
1.54
1.77
2.1
2.8
4.74
6.07
ug/l
0.40
34
255
13
61
2.18
1.74
1.3
1.4
—
—
—
0
0
14
68
2.11
1.73
1.8
1.5
283.14
296.10
ug/g
—
7
34
8
31
2.62
1.67
1.8
2.4
—
—
—
0
0
7
25
2.84
1.66
1.0
1.1
—
—
—
0
0
13
64
2.08
1.56
1.1
1.5
—
—
—
0
0
5
16
3.16
1.44
2.4
1.0
—
—
—
0
0
5
17
2.97
1.36
2.4
2.3
—
—
—
0
0
9
42
2.18
1.35
1.0
1.6
—
—
—
0
0
9
42
2.18
1.35
1.0
1.6
—
—
—
0
0
39
278
1.46
1.33
1.6
1.3
—
—
—
0
0
8
34
2.39
1.30
1.3
1.6
—
—
—
0
0
9
44
2.08
1.28
1.3
1.2
—
—
—
0
0
8
35
2.32
1.28
1.4
1.5
—
—
—
0
0
40
290
1.44
1.25
1.6
1.4
—
—
—
0
0
8
36
2.25
1.25
1.3
1.5
—
—
—
0
0
8
36
2.25
1.25
1.4
1.5
—
—
—
0
0
8
36
2.25
1.25
1.3
1.5
—
—
—
0
0
8
36
2.25
1.25
1.4
1.5
—
—
—
0
0
6
25
2.43
1.25
2.0
1.4
325.17
333.84
u/l
—
6
25
17
101
1.72
1.22
1.5
4.1
—
2.57
—
0
12
8
37
2.19
1.22
1.3
1.5
—
—
—
0
0
13
71
1.87
1.21
1.7
2.7
120.23
100.43
ug/min
—
7
47
8
38
2.13
1.19
1.5
1.2
—
—
—
0
0
6
26
2.33
1.19
1.0
1.8
—
—
—
0
0
39
285
1.42
1.18
3.9
3.7
—
—
—
0
0
8
39
2.08
1.16
1.3
1.5
—
—
—
0
0
12
65
1.88
1.15
1.1
1.5
—
—
—
0
0
37
270
1.42
1.13
4.9
3.9
5.72
5.79
kpa
0.19
37
263
7
30
2.36
1.13
1.1
1.1
—
—
—
0
0
49
376
1.36
1.12
1.5
1.3
18.93
37.23
iu/ml
2.31
18
126
240
2249
1.29
1.11
26.1
16.1
70.80
73.03
ml/min/173m2
0.67
193
1839
68
549
1.31
1.11
1.8
1.7
1.32
1.55
mg/l
0.35
57
425
8
41
1.98
1.09
4.1
2.9
61.00
59.80
%
—
8
41
10
52
1.95
1.07
1.2
1.4
—
—
—
0
0
20
130
1.58
1.05
1.1
1.4
—
38.93
—
0
10
5
22
2.29
1.04
1.2
1.4
—
—
—
0
0
9
47
1.94
1.03
1.2
1.5
—
—
—
0
0
9
48
1.90
1.01
1.1
1.5
—
—
—
0
0
5
23
2.19
0.98
1.0
1.8
—
—
—
0
0
5
23
2.19
0.98
1.0
1.8
—
—
—
0
0
5
23
2.19
0.98
1.0
1.8
—
—
—
0
0
7
36
1.97
0.97
1.1
1.2
—
—
—
0
0
46
359
1.33
0.96
1.4
1.3
7.51
12.57
u/ml
0.29
17
134
12
70
1.74
0.94
2.3
1.6
—
—
—
0
0
15
96
1.59
0.86
1.1
1.2
—
—
—
0
0
6
31
1.95
0.85
1.2
1.3
—
—
—
0
0
43
340
1.31
0.83
10.0
8.3
—
—
—
0
0
6
32
1.89
0.82
1.3
1.8
—
—
—
0
0
98
860
1.20
0.77
5.7
5.4
13.45
2.63
ug/l
0.49
90
754
10
59
1.72
0.76
1.2
1.3
—
—
—
0
0
9
54
1.69
0.75
1.1
1.2
—
—
—
0
0
6
108
0.55
0.74
1.0
1.0
—
—
—
0
0
21
151
1.42
0.73
6.3
5.8
25.27
24.71
mmol/l
0.34
21
151
7
39
1.81
0.73
1.1
1.4
—
—
—
0
0
79
684
1.21
0.72
4.9
4.7
22.58
21.62
%
0.21
40
355
21
152
1.41
0.71
2.4
2.6
1.10
0.67
%
0.73
21
152
13
85
1.55
0.70
1.3
1.6
—
—
—
0
0
11
69
1.62
0.69
1.8
1.3
—
—
—
0
0
7
120
0.57
0.69
1.6
1.7
—
—
—
0
0
5
29
1.74
0.64
1.0
1.4
—
—
—
0
0
5
29
1.74
0.64
1.0
1.4
—
—
—
0
0
5
30
1.68
0.61
1.8
1.2
—
—
—
0
0
5
30
1.68
0.61
1.4
2.5
—
—
—
0
0
25
192
1.33
0.61
4.6
2.9
69.69
57.81
ml/min/173m2
0.78
13
78
25
193
1.32
0.59
2.0
1.9
1.74
1.64
%
0.19
19
161
9
63
1.44
0.52
1.8
1.2
—
—
—
0
0
6
40
1.51
0.52
1.3
1.5
—
—
—
0
0
5
32
1.57
0.42
1.2
1.0
—
—
—
0
0
5
35
1.44
0.39
1.0
1.1
—
—
—
0
0
51
451
1.16
0.38
3.4
3.1
3.59
2.42
e6/l
0.37
30
249
5
36
1.40
0.38
1.4
1.3
—
—
—
0
0
6
44
1.37
0.34
1.0
1.2
—
—
—
0
0
6
86
0.69
0.33
1.2
1.2
—
—
—
0
0
7
55
1.28
0.30
2.7
1.9
—
—
—
0
0
37
328
1.15
0.28
3.9
4.3
4.86
41.09
ug/l
0.91
29
282
9
117
0.76
0.28
1.1
1.2
—
—
—
0
0
8
64
1.26
0.27
2.0
1.4
—
—
—
0
0
8
64
1.26
0.27
2.0
1.4
—
—
—
0
0
6
85
0.70
0.24
1.2
1.2
—
—
—
0
0
5
42
1.19
0.21
1.4
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
84
794
1.08
0.21
3.9
3.3
0.32
0.44
e6/l
0.47
66
599
0
13
0.00
0.21
0.0
1.2
—
120.92
—
0
13
0
13
0.00
0.21
0.0
1.2
—
49.31
—
0
13
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
18
156
1.16
0.19
2.3
2.6
0.98
1.16
%
0.58
18
156
8
72
1.11
0.16
1.1
1.2
—
—
—
0
0
51
482
1.07
0.13
3.2
2.9
2.06
1.20
e6/l
0.49
31
277
14
123
1.14
0.12
4.6
3.0
25.36
45.61
u/ml
0.89
14
118
10
114
0.87
0.09
1.6
1.9
—
—
—
0
0
6
55
1.09
0.09
1.5
1.5
—
—
—
0
0
9
102
0.88
0.06
1.3
1.8
—
—
—
0
0
35
336
1.05
0.05
4.7
4.7
30.95
32.68
%
0.44
20
216
47
480
0.98
0.02
2.8
3.1
1.45
0.82
ug/l
0.36
35
335
57
579
0.98
0.02
3.1
3.1
2.47
2.46
mmol/l
0.23
51
506
66
653
1.01
0.01
1.8
1.6
1.33
1.27
mmol/l
0.29
61
538
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.9
—
13.52
—
0
9
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
44.80
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
2.90
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
1.0
1.1
19.62
53.18
u/l
—
5
42
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_PEMPHIGOID_NAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PEMPHIGOID_NAS | 1.903 [1.56, 2.32] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.044 |
During the follow-up period (1.1.1998 — 31.12.2019), 546 out of 1148 females with L12_PEMPHIGOID_NAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PEMPHIGOID_NAS | 2.036 [1.5, 2.76] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 407 out of 732 males with L12_PEMPHIGOID_NAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_PEMPHIGOID_NAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.148% | 0.367% |
| 5 | 1.004% | 2.224% |
| 10 | 2.413% | 5.341% |
| 15 | 4.364% | 10.53% |
| 20 | 7.81% | 17.358% |
Relationships between endpoints
↥Index endpoint: L12_PEMPHIGOID_NAS – Other and unspecified pemphigoid
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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