Urticaria due to cold and heat

L12_URTICA_COLDHEAT

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L50.2
  • Hospital discharge: ICD-9 7082
  • Cause of death: ICD-10 L50.2
  • Cause of death: ICD-9 7082

2 out of 7 registries used, show all original rules.

313

4. Check minimum number of events

None

313

5. Include endpoints

None

313

6. Filter based on genotype QC (FinnGen only)

313

Control definitions (FinnGen only)

Control exclude
L12_URTICARIAERYTHEMA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L50
Name in latin
Urticaria ex calore

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2310 1500 804
Only index persons 2168 1431 737
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.02
Only index persons 0.04 0.05 0.03
Median age at first event (years)
Whole population 28.24 32.69 19.84
Only index persons 29.01 33.50 20.28

-FinnGen-

Key figures

All Female Male
Number of individuals 313 235 78
Unadjusted period prevalence (%) 0.07 0.08 0.03
Median age at first event (years) 38.60 39.73 35.19

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
282
Matched controls
2821
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L50.2
ICD-10 Finland
Urticaria due to cold and heat
+∞
323.0
272
*
L50.3
ICD-10 Finland
Dermatographic urticaria
389.0
63.1
61
*
L50.9
ICD-10 Finland
Urticaria, unspecified
30.7
42.7
57
23
R06AE09
ATC
levocetirizine; oral
7.0
40.4
120
271
L50.8
ICD-10 Finland
Other urticaria
+∞
38.4
36
*
C01CA24
ATC
epinephrine; parenteral
9.1
32.5
73
104
R06AX27
ATC
desloratadine; oral
4.4
30.1
156
614
XQ800
NOMESCO Finland
Prick test
7.0
28.9
78
145
XQ810
NOMESCO Finland
Physical test for urticaria
+∞
27.5
26
*
R06AE07
ATC
cetirizine; oral
3.5
22.2
185
989
H02AB06
ATC
prednisolone; systemic
3.4
21.7
167
837
R03DC03
ATC
montelukast; oral
4.2
20.6
92
292
L50.5
ICD-10 Finland
Cholinergic urticaria
+∞
20.0
19
*
L50.0
ICD-10 Finland
Allergic urticaria
23.8
19.9
28
13
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
5.0
18.7
65
159
R06AX22
ATC
ebastine; oral
3.8
17.7
88
302
L50.1
ICD-10 Finland
Idiopathic urticaria
135.8
12.5
13
*
7082A
ICD-9 Finland
Urticaria due to cold and heat[URTICARIA E FRIGORE]
+∞
11.5
11
*
A02BC02
ATC
pantoprazole; systemic
2.4
11.1
183
1228
R06AX13
ATC
loratadine; oral
2.9
11.0
74
304
D07AA02
ATC
hydrocortisone; topical
3.1
10.7
64
243
R03AC02
ATC
salbutamol; inhalant
2.2
9.8
169
1126
H02AB07
ATC
prednisone; oral
3.2
9.8
54
193
L20.0
ICD-10 Finland
Besnier prurigo
3.8
9.8
42
124
E000003
ATC
NA
5.2
9.3
28
58
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.8
9.3
63
259
J45.9
ICD-10 Finland
Asthma, unspecified
2.8
9.2
63
261
R01AD09
ATC
mometasone; nasal
2.2
9.0
149
959
M79.6
ICD-10 Finland
Pain in limb
2.2
8.3
109
629
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
8.2
119
717
T78.4
ICD-10 Finland
Allergy, unspecified
4.5
8.1
28
68
R06AX26
ATC
fexofenadine; oral
3.6
8.0
36
111
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
3.6
7.9
35
106
D07AC13
ATC
mometasone; topical
2.2
7.9
95
526
J45.0
ICD-10 Finland
Predominantly allergic asthma
3.2
7.7
41
143
R01AD12
ATC
fluticasone furoate; nasal
2.1
7.6
113
683
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
7.5
70
341
E000002
ATC
NA
2.8
7.3
49
198
344
Kela drug reimbursment
Omalizumab
+∞
7.3
7
*
T78.3
ICD-10 Finland
Angioneurotic oedema
16.3
7.3
11
7
X49
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified chemicals and noxious substances
16.3
7.3
11
7
M79.1
ICD-10 Finland
Myalgia
2.7
7.2
49
201
R06.0
ICD-10 Finland
Dyspnoea
2.4
7.2
64
304
L50
ICD-10 Finland
Urticaria
9.1
7.1
14
16
E0000UV
ATC
NA
2.0
7.0
131
856
E000001
ATC
NA
2.2
6.8
74
386
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.4
6.8
64
313
D07AB08
ATC
desonide; topical
2.9
6.7
40
151
R06AX18
ATC
acrivastine; oral
5.8
6.7
18
33
R20.2
ICD-10 Finland
Paraesthesia of skin
3.2
6.5
33
112
R03BA02
ATC
budesonide; inhalant
2.3
6.5
62
306
G44.2
ICD-10 Finland
Tension-type headache
2.6
6.4
47
201
XQ802
NOMESCO Finland
Epicutan test
4.3
6.4
22
54
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
4.6
6.2
20
46
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
2.1
6.2
77
427

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
98
373
3.37
20.40
1.6
1.4
453.3
498.5
titre
0.14
27
80
203
1269
2.71
15.73
7.2
5.4
0.0
0.0
e9/l
0.19
178
1099
208
1319
2.72
15.60
7.2
5.9
0.2
0.2
e9/l
0.44
185
1161
201
1264
2.65
15.16
7.1
5.4
0.5
0.5
e9/l
1.22
178
1098
204
1313
2.59
14.32
7.1
5.4
2.0
2.1
e9/l
0.34
183
1162
184
1138
2.50
13.93
7.1
5.4
0.7
0.7
%
0.35
173
1066
185
1180
2.39
12.61
7.1
5.4
3.0
2.7
%
0.75
175
1101
186
1190
2.39
12.58
7.3
5.6
8.1
8.2
%
0.15
176
1123
253
1867
2.85
12.49
5.1
3.8
9.6
9.7
mm/h
0.07
247
1732
189
1227
2.36
12.22
7.2
5.4
30.1
29.8
%
0.14
180
1160
188
1218
2.36
12.21
6.9
5.2
55.2
55.9
%
0.43
178
1156
211
1466
2.35
11.24
9.2
9.0
3.8
4.0
e9/l
0.51
188
1283
132
816
2.07
8.74
6.5
5.2
—
—
—
0
0
12
18
6.89
7.66
1.4
1.4
0.2
0.2
u/ml
—
5
7
19
45
4.43
7.58
1.2
1.0
11.2
4.5
u/ml
—
8
14
91
512
2.10
7.58
1.4
1.3
31.2
28.3
iu/ml
0.10
24
165
76
400
2.19
7.51
2.7
2.4
47.1
112.9
ug/g
3.13
63
311
21
56
3.95
7.21
1.3
1.0
3.4
5.0
u/ml
—
5
13
284
2427
2.84
7.10
5.4
4.6
1.7
1.8
mu/l
0.92
276
2259
38
150
2.75
7.00
1.6
1.8
1.5
1.5
g/l
0.05
38
142
101
624
1.91
6.31
2.1
2.1
136.1
296.6
u/l
0.82
95
594
230
1839
1.95
6.27
7.9
6.8
72.3
75.7
u/l
0.88
222
1723
86
504
1.97
6.27
1.3
1.3
7.7
8.2
u/ml
0.05
40
196
94
568
1.94
6.27
2.3
2.6
316.8
6283.7
umol/l
2.48
86
496
100
618
1.91
6.23
5.0
4.6
—
—
—
0
0
67
362
2.08
6.10
2.8
2.6
2.4
2.4
mmol/l
0.02
62
318
251
2078
2.05
6.05
4.6
4.0
14.4
14.5
pmol/l
0.06
240
1910
174
1285
1.80
6.02
3.3
2.7
115.1
80.2
ug/l
1.70
164
1206
97
608
1.86
5.72
1.4
1.4
2.5
2.1
g/l
0.94
70
388
48
240
2.18
5.30
1.4
1.2
116.3
178.8
iu/ml
0.50
11
105
96
619
1.79
5.08
7.5
6.9
—
—
—
0
0
15
41
3.79
4.98
1.0
1.1
—
—
—
0
0
52
279
2.04
4.78
1.9
2.5
6.4
7.1
umol/l
0.14
45
240
48
252
2.07
4.67
1.5
1.4
—
—
—
0
0
20
70
2.98
4.58
1.2
1.1
2.0
3.7
u/ml
0.42
12
27
140
1032
1.65
4.43
2.2
2.0
—
—
—
0
0
126
910
1.64
4.29
4.3
4.1
37.7
36.8
g/l
1.19
119
863
15
46
3.37
4.24
1.3
1.2
—
—
—
0
0
35
170
2.19
4.15
1.4
1.2
—
—
—
0
0
210
1730
1.65
4.13
4.8
3.9
—
—
—
0
0
36
178
2.16
4.09
1.8
2.5
26611.2
3429.9
u/l
1.02
11
79
256
2229
1.82
4.04
4.6
4.6
37.4
38.5
mmol/mol
1.81
248
2108
23
94
2.56
3.98
1.2
1.1
—
—
—
0
0
150
1147
1.59
3.95
9.6
7.8
0.0
0.0
e9/l
0.56
122
927
289
2630
2.29
3.87
14.9
10.7
18.5
20.1
mg/l
0.38
235
1988
85
567
1.69
3.87
2.3
2.0
2.6
2.9
mg/l
0.49
72
484
34
170
2.12
3.76
4.1
4.5
0.0
0.1
%
—
7
43
49
281
1.88
3.71
2.2
2.1
26.0
25.0
%
0.18
43
243
59
359
1.79
3.70
4.4
3.3
62.3
406.9
ng/l
0.98
32
226
99
694
1.62
3.70
1.3
1.3
0.6
1.0
u/ml
1.57
23
196
12
35
3.53
3.65
1.0
1.1
—
—
—
0
0
17
62
2.84
3.65
1.1
1.1
11.5
6.1
u/ml
—
10
35
105
749
1.60
3.64
2.5
3.0
2.4
2.4
mmol/l
0.20
96
668
90
619
1.64
3.62
2.7
2.6
0.2
0.3
e6/l
0.39
66
452
117
858
1.58
3.61
1.9
1.8
102.8
98.4
pmol/l
0.40
60
434
34
173
2.08
3.60
4.1
3.9
0.2
0.3
%
—
5
35
113
824
1.58
3.56
3.4
3.1
34.3
55.3
e6/l
0.53
79
558
51
309
1.78
3.24
2.2
2.0
2.4
2.5
g/l
0.42
44
288
88
619
1.59
3.19
2.6
2.5
—
—
—
0
0
17
67
2.63
3.18
2.2
2.5
—
—
—
0
0
267
2404
1.75
3.12
3.9
3.7
5.7
5.7
mmol/l
0.00
259
2231
95
688
1.55
3.01
2.7
2.7
17.7
56.0
e6/l
1.86
73
518
15
57
2.71
3.01
1.1
1.1
0.7
0.6
u/ml
—
8
24
49
302
1.74
2.94
1.2
1.2
—
—
—
0
0
34
187
1.92
2.93
4.1
4.3
0.6
0.6
%
—
7
52
92
669
1.53
2.84
2.8
2.5
—
—
—
0
0
36
204
1.86
2.84
1.9
2.7
1.7
1.8
%
0.25
36
183
12
42
2.93
2.78
1.1
1.0
9.9
6.9
u/ml
—
6
14
68
464
1.59
2.77
2.5
2.2
6.0
7.6
e6/l
0.34
62
406
18
79
2.36
2.73
1.5
1.7
—
—
—
0
0
9
24
3.83
2.69
2.7
2.2
—
—
—
0
0
188
1594
1.45
2.60
3.2
3.1
—
—
—
0
0
27
143
1.97
2.60
1.6
2.7
75.8
72.1
e9/l
0.20
19
104
18
81
2.30
2.59
1.1
1.2
—
—
—
0
0
37
218
1.79
2.59
28.8
16.2
1.3
1.2
inr
0.17
15
31
15
62
2.49
2.58
1.5
1.3
—
—
—
0
0
6
11
5.54
2.55
1.0
1.1
—
—
—
0
0
100
756
1.47
2.53
2.9
2.9
21.4
27.7
ng/l
0.30
43
416
16
70
2.35
2.45
1.1
1.3
—
3.5
—
0
11
253
2288
1.55
2.43
15.1
13.3
13.3
13.4
%
1.45
248
2257
6
12
5.07
2.41
1.0
1.2
—
—
—
0
0
97
736
1.46
2.39
1.9
2.0
—
—
—
0
0
56
379
1.58
2.36
1.4
1.5
—
—
—
0
0
14
59
2.44
2.32
1.0
1.3
272.5
238.8
u/ml
—
9
33
159
1325
1.41
2.32
4.5
3.8
6.4
6.5
mmol/l
0.24
152
1206
8
23
3.54
2.28
1.0
1.1
—
—
—
0
0
87
652
1.46
2.28
2.4
3.4
7.4
7.4
ph
0.27
14
105
8
24
3.39
2.19
1.1
1.2
—
—
—
0
0
6
14
4.35
2.16
1.5
1.7
3.2
2.8
mg/l
—
6
14
6
14
4.35
2.16
1.0
1.4
1.7
1.9
mmol/l
—
6
14
13
55
2.42
2.15
1.0
1.2
—
—
—
0
0
132
1078
1.39
2.12
4.9
5.7
1.2
1.2
mmol/l
0.03
118
935
9
31
2.96
2.09
1.3
1.3
—
—
—
0
0
75
555
1.46
2.08
2.4
1.6
0.8
0.8
mg/l
0.02
53
418
22
122
1.86
1.89
1.7
1.2
—
—
—
0
0
9
35
2.62
1.81
1.3
1.2
—
—
—
0
0
77
592
1.40
1.73
1.7
1.7
—
—
—
0
0
10
42
2.43
1.69
1.0
1.4
—
—
—
0
0
91
725
1.36
1.64
3.2
2.3
57.6
55.9
u/l
0.22
83
680
5
14
3.61
1.62
1.0
1.1
1980.0
1714.1
miu/ml
—
5
14
22
129
1.76
1.61
1.1
1.3
—
—
—
0
0
64
482
1.41
1.61
1.4
1.4
19.5
22.1
nmol/l
0.84
58
416
7
26
2.73
1.59
1.4
1.7
—
—
—
0
0
6
20
3.04
1.59
2.0
1.8
0.3
0.2
e9/l
—
6
15
56
414
1.43
1.56
1.7
1.6
423.6
14006044.5
pmol/l
0.50
50
357
40
277
1.51
1.54
1.6
1.4
—
—
—
0
0
5
15
3.37
1.53
1.4
1.3
187.4
110.4
iu/ml
—
5
15
5
15
3.37
1.53
1.0
1.1
—
—
—
0
0
5
15
3.37
1.53
1.2
1.2
—
—
—
0
0
14
72
1.99
1.51
1.1
1.3
454.6
390.6
mg/l
0.58
14
67
6
21
2.89
1.51
2.2
2.5
—
—
—
0
0
142
1223
1.29
1.46
4.7
4.3
0.0
0.0
estimate
0.50
33
244
21
126
1.71
1.44
1.1
1.1
—
—
—
0
0
46
333
1.45
1.44
1.7
1.7
1189.0
1168.5
nmol/l
0.05
36
248
6
22
2.76
1.44
1.8
1.5
35.0
33.1
pg
—
6
22
143
1236
1.29
1.42
3.6
3.1
0.0
0.0
estimate
0.00
31
235
141
1221
1.28
1.37
3.7
3.1
0.0
0.0
estimate
0.00
33
239
34
234
1.51
1.36
1.2
1.4
—
—
—
0
0
25
160
1.61
1.36
1.2
1.1
—
—
—
0
0
115
972
1.29
1.34
3.3
2.9
—
—
—
0
0
27
177
1.58
1.34
1.4
1.4
27.0
24.2
iu/l
0.13
20
147
14
76
1.88
1.32
2.3
1.8
20.6
20.6
s
—
9
65
115
974
1.29
1.32
4.1
5.0
1.2
1.2
mmol/l
0.09
106
906
9
43
2.12
1.31
1.2
1.1
—
—
—
0
0
6
24
2.53
1.31
1.3
2.0
—
—
—
0
0
8
34
2.39
1.30
1.3
1.1
—
—
—
0
0
11
55
2.04
1.29
2.2
1.7
—
—
—
0
0
8
35
2.32
1.28
2.9
2.1
—
—
—
0
0
27
180
1.55
1.26
3.4
3.1
—
—
—
0
0
80
651
1.31
1.23
4.1
3.3
0.0
0.0
estimate
0.80
33
238
22
141
1.60
1.21
1.7
2.3
68.6
67.5
g/l
0.32
22
129
11
57
1.96
1.18
1.0
1.1
—
—
—
0
0
11
57
1.96
1.18
1.0
1.1
—
—
—
0
0
8
39
2.08
1.16
2.3
4.7
3.9
4.3
e9/l
—
8
39
266
2523
1.36
1.15
4.6
4.1
3.0
2.8
mmol/l
2.28
258
2364
8
40
2.03
1.13
2.4
4.9
56.3
56.3
%
—
8
40
263
2494
1.34
1.11
4.3
3.8
4.9
4.8
mmol/l
1.24
256
2346
5
21
2.40
1.09
3.8
2.6
17.9
18.6
mu/l
—
5
21
5
21
2.40
1.09
1.0
1.1
—
—
—
0
0
34
246
1.43
1.09
1.1
1.1
—
—
—
0
0
264
2508
1.34
1.07
14.9
11.6
40.7
40.4
%
0.36
219
2000
67
546
1.29
1.02
3.8
3.1
—
—
—
0
0
11
61
1.83
0.99
1.1
1.4
—
—
—
0
0
71
586
1.27
0.98
2.7
3.2
—
—
—
0
0
18
117
1.57
0.96
1.6
2.2
—
—
—
0
0
10
55
1.85
0.93
1.4
1.1
—
—
—
0
0
24
169
1.46
0.90
1.3
1.2
—
—
—
0
0
17
113
1.53
0.84
2.7
2.9
217.5
132.8
ng/l
0.22
12
103
20
138
1.48
0.84
1.6
1.3
134.0
283.3
miu/ml
—
9
64
250
2384
1.24
0.80
3.9
3.4
1.4
1.3
mmol/l
2.55
241
2239
14
90
1.58
0.79
1.2
1.2
—
—
—
0
0
6
34
1.78
0.76
1.2
1.4
—
—
—
0
0
35
273
1.32
0.75
1.5
1.3
—
—
—
0
0
15
100
1.53
0.74
9.5
8.3
0.5
0.7
%
1.12
15
100
259
2486
1.24
0.73
4.2
3.8
1.5
1.5
mmol/l
0.79
250
2335
5
25
2.02
0.73
2.4
2.0
—
—
—
0
0
5
25
2.02
0.73
1.0
1.1
—
—
—
0
0
15
101
1.51
0.71
9.5
8.2
1.2
1.5
%
0.56
15
101
5
26
1.94
0.71
1.0
1.4
—
—
—
0
0
5
26
1.94
0.71
1.0
1.2
—
—
—
0
0
9
58
1.57
0.70
1.0
1.3
—
—
—
0
0
81
706
1.20
0.69
2.9
2.7
—
—
—
0
0
5
28
1.80
0.66
1.6
1.4
—
—
—
0
0
87
770
1.18
0.62
2.2
2.1
—
—
—
0
0
5
30
1.68
0.61
1.0
1.5
—
—
—
0
0
39
319
1.25
0.61
1.5
1.9
—
—
—
0
0
0
20
0.00
0.60
0.0
1.5
—
—
—
0
0
0
21
0.00
0.60
0.0
2.2
—
—
—
0
0
55
469
1.21
0.59
1.7
1.7
—
—
—
0
0
0
23
0.00
0.58
0.0
2.3
—
—
—
0
0
24
185
1.32
0.58
1.3
1.3
—
—
—
0
0
41
342
1.23
0.55
1.7
1.8
—
—
—
0
0
284
2773
1.26
0.53
10.6
10.1
—
—
—
0
0
85
763
1.16
0.51
7.0
6.3
1.1
1.1
inr
0.21
29
232
33
271
1.24
0.51
1.3
1.5
—
—
—
0
0
25
199
1.28
0.49
2.8
2.3
0.6
0.7
ug/l
0.07
13
113
7
46
1.53
0.48
1.3
1.8
—
—
—
0
0
18
137
1.33
0.48
1.8
2.2
—
—
—
0
0
15
111
1.37
0.47
7.5
6.6
24.2
25.3
mmol/l
0.72
15
111
72
645
1.15
0.45
1.7
1.6
1.7
1.4
mmol/l
1.12
67
571
21
166
1.28
0.44
1.3
1.4
—
—
—
0
0
14
185
0.75
0.44
1.9
1.7
—
—
—
0
0
9
130
0.68
0.44
2.7
2.7
—
—
—
0
0
24
194
1.26
0.43
1.7
1.7
—
—
—
0
0
5
32
1.57
0.42
1.0
1.5
—
—
—
0
0
8
58
1.39
0.42
2.1
1.9
—
—
—
0
0
5
33
1.52
0.41
1.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
5
34
1.48
0.40
2.0
3.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
127
1192
1.11
0.38
4.0
3.8
—
—
—
0
0
10
72
1.40
0.37
2.7
3.6
135.0
123.5
u/ml
—
10
63
13
100
1.31
0.34
2.5
2.0
—
—
—
0
0
13
103
1.27
0.28
1.4
1.6
—
—
—
0
0
16
192
0.82
0.26
4.1
4.3
6.3
30.4
ug/l
—
9
151
10
78
1.29
0.24
11.0
7.9
—
—
—
0
0
5
39
1.29
0.23
1.4
2.1
—
—
—
0
0
16
188
0.84
0.22
1.8
1.9
—
—
—
0
0
18
154
1.18
0.21
8.1
7.6
120.4
123.2
g/l
0.35
18
148
15
177
0.84
0.21
1.7
1.9
—
—
—
0
0
105
1001
1.07
0.21
2.4
2.5
—
—
—
0
0
16
187
0.85
0.21
1.8
1.9
—
—
—
0
0
16
187
0.85
0.21
1.7
1.9
—
—
—
0
0
25
221
1.14
0.21
3.8
3.1
—
—
—
0
0
23
202
1.15
0.21
3.0
4.2
—
—
—
0
0
13
155
0.83
0.20
1.8
2.0
—
—
—
0
0
19
218
0.86
0.20
1.4
1.4
—
—
—
0
0
6
51
1.18
0.19
2.2
1.2
—
—
—
0
0
28
252
1.12
0.18
4.5
5.1
1.1
1.1
mmol/l
0.55
23
233
14
119
1.18
0.18
1.8
1.4
—
—
—
0
0
14
119
1.18
0.18
1.8
1.4
—
—
—
0
0
32
292
1.11
0.17
3.9
1.9
31.9
29.1
s
1.28
32
285
8
70
1.15
0.16
3.5
4.8
—
—
—
0
0
6
76
0.79
0.16
1.3
1.3
—
—
—
0
0
7
88
0.79
0.14
15.9
7.6
—
—
—
0
0
70
668
1.06
0.14
2.8
3.1
7.5
7.8
mmol/l
0.33
63
571
48
509
0.93
0.14
3.6
3.9
—
—
—
0
0
14
123
1.14
0.12
1.9
1.5
—
—
—
0
0
58
553
1.06
0.12
3.1
3.4
54.7
57.6
mg/l
0.03
37
346
17
154
1.11
0.10
9.5
6.9
—
—
—
0
0
5
45
1.11
0.10
1.6
1.4
—
—
—
0
0
45
430
1.05
0.09
1.8
1.5
—
—
—
0
0
5
64
0.78
0.08
2.6
5.4
1.6
1.1
mmol/l
—
5
54
11
98
1.13
0.07
3.6
3.9
—
—
—
0
0
9
88
1.02
0.07
1.8
2.5
—
—
—
0
0
80
817
0.97
0.05
1.8
1.6
—
—
—
0
0
10
109
0.91
0.04
4.0
7.2
25.0
25.0
mmol/l
—
10
102
19
181
1.05
0.03
2.9
3.3
5.9
5.8
kpa
0.52
19
176
35
359
0.97
0.02
1.3
1.3
—
—
—
0
0
11
103
1.07
0.02
2.3
4.4
—
—
—
0
0
57
578
0.98
0.01
3.7
4.2
9.8
10.4
mg/mmol
0.03
39
360
19
184
1.03
0.00
3.3
3.3
—
—
—
0
0
11
111
0.99
0.00
2.4
2.4
0.0
0.1
e6/l
2.41
11
105
31
315
0.98
0.00
1.4
1.2
—
—
—
0
0
13
126
1.03
0.00
3.7
3.8
—
7.4
—
0
8
56
556
1.01
0.00
4.2
3.2
1.0
1.0
kg/l
—
7
67
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
4.8
—
41.4
—
0
5
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
9
97
0.93
0.00
1.7
2.8
—
—
—
0
0
6
63
0.95
0.00
1.5
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
1.2
—
0
5
0
6
0.00
0.00
0.0
1.3
—
1.7
—
0
6
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint L12_URTICA_COLDHEAT and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_URTICA_COLDHEAT.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: L12_URTICA_COLDHEAT – Urticaria due to cold and heat

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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