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Urticaria due to cold and heat

DOID EFO Endpoint Browser PheWeb

L12_URTICA_COLDHEAT

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L50.2
  • Hospital discharge: ICD-9 — 7082
  • Cause of death: ICD-10 — L50.2
  • Cause of death: ICD-9 — 7082

2 out of 7 registries used, show all original rules.

324

4. Check minimum number of events

None

324

5. Include endpoints

None

324

6. Filter based on genotype QC (FinnGen only)

305

Control definitions (FinnGen only)

Control exclude
L12_URTICARIAERYTHEMA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L50
Name in latin
Urticaria ex calore

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2310 1500 804
Only index persons 2168 1431 737
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.02
Only index persons 0.04 0.05 0.03
Median age at first event (years)
Whole population 28.24 32.69 19.84
Only index persons 29.01 33.50 20.28

-FinnGen-

Key figures

All Female Male
Number of individuals 305 234 71
Unadjusted period prevalence (%) 0.07 0.08 0.03
Median age at first event (years) 39.02 40.07 35.59

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
324
Matched controls
3240
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L50.2
ICD-10 Finland
Urticaria due to cold and heat
16384.0
307.7
310
*
L50.9
ICD-10 Finland
Urticaria, unspecified
24.4
86.6
65
33
XQ800
NOMESCO Finland
Prick test
10.9
71.2
89
109
C01CA24
ATC
epinephrine; parenteral
11.0
70.3
87
105
L50.3
ICD-10 Finland
Dermatographic urticaria
148.1
68.0
70
6
R06AE09
ATC
levocetirizine; oral
7.1
63.8
135
298
R06AX27
ATC
desloratadine; oral
4.9
44.7
191
734
L50.8
ICD-10 Finland
Other urticaria
126.8
41.9
44
*
R03DC03
ATC
montelukast; oral
4.5
34.1
113
346
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
5.4
32.6
75
170
R06AE07
ATC
cetirizine; oral
4.0
30.9
219
1116
XQ810
NOMESCO Finland
Physical test for urticaria
+∞
29.6
28
*
R06AX22
ATC
ebastine; oral
4.1
29.3
108
353
H02AB06
ATC
prednisolone; systemic
3.6
28.6
200
993
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
8.6
23.8
32
41
L50.0
ICD-10 Finland
Allergic urticaria
23.5
22.6
32
15
L50.5
ICD-10 Finland
Cholinergic urticaria
+∞
22.1
21
*
T78.4
ICD-10 Finland
Allergy, unspecified
6.0
19.8
37
68
R06AX13
ATC
loratadine; oral
3.3
18.5
88
330
H02AB07
ATC
prednisone; oral
3.5
16.7
65
214
7082A
ICD-9 Finland
Urticaria due to cold and heat[URTICARIA E FRIGORE]
+∞
14.7
14
*
D07AC13
ATC
mometasone; topical
2.6
14.6
117
574
D07AA02
ATC
hydrocortisone; topical
2.9
13.9
81
336
XQ802
NOMESCO Finland
Epicutan test
5.1
13.3
29
61
E000003, ,
ATC
4.7
13.2
32
74
L50.1
ICD-10 Finland
Idiopathic urticaria
29.8
13.1
17
6
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
3.7
13.0
44
131
E0000UV, ,
ATC
2.3
12.5
168
1025
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
4.8
12.4
29
65
R06AX26
ATC
fexofenadine; oral
3.4
12.0
46
149
R03AC02
ATC
salbutamol; inhalant
2.3
11.7
215
1480
E000002, ,
ATC
3.0
11.4
57
216
E000001, ,
ATC
2.5
11.0
90
438
J45.9
ICD-10 Finland
Asthma, unspecified
2.5
10.9
81
376
A02BC02
ATC
pantoprazole; systemic
2.3
10.8
222
1577
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.5
10.4
80
378
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.2
10.3
146
890
R01AD58
ATC
fluticasone, combinations; nasal
2.3
10.3
111
607
R01AD09
ATC
mometasone; nasal
2.1
10.2
181
1203
Z71.8
ICD-10 Finland
Other specified counselling
2.2
10.1
128
747
L20.0
ICD-10 Finland
Besnier prurigo
2.9
9.8
49
185
J01AA02
ATC
doxycycline; systemic
2.4
9.8
250
1905
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
9.6
86
433
R20.2
ICD-10 Finland
Paraesthesia of skin
3.3
9.5
38
126
344
Kela drug reimbursment
Omalizumab
102.9
9.5
10
*
R01AD12
ATC
fluticasone furoate; nasal
2.1
9.4
137
838
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.8
9.3
49
191
M79.1
ICD-10 Finland
Myalgia
2.4
9.0
68
317
R42
ICD-10 Finland
Dizziness and giddiness
2.4
8.9
74
360
N06AA12
ATC
doxepin; systemic
4.0
8.8
26
70
D07AB02
ATC
hydrocortisone butyrate; topical
2.1
8.5
110
638
A02BA02
ATC
ranitidine; systemic
2.5
8.4
60
272
D02AX
ATC
Other emollients and protectives
4.7
8.2
19
42
R06AX18
ATC
acrivastine; oral
6.6
8.1
20
32
L50
ICD-10 Finland
Urticaria
7.6
8.1
18
25
X49
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified chemicals and noxious substances
22.7
8.1
11
5
S01GX01
ATC
cromoglicic acid; ophthalmic
2.1
7.9
91
503
J02AC01
ATC
fluconazole; systemic
1.9
7.9
155
1038
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
2.0
7.8
109
647
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.2
7.7
77
402
D07AB08
ATC
desonide; topical
2.5
7.5
50
219
R03DX05
ATC
omalizumab; parenteral
81.9
7.4
8
*
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
12.4
7.1
12
10
T78.3
ICD-10 Finland
Angioneurotic oedema
12.4
7.1
12
10
R03BA02
ATC
budesonide; inhalant
2.1
7.1
75
400
D07XC01
ATC
betamethasone; topical
2.5
6.8
44
189
R03AK07
ATC
formoterol and budesonide; inhalant
2.1
6.8
81
451
G44.2
ICD-10 Finland
Tension-type headache
2.2
6.8
62
311
A02BC05
ATC
esomeprazole; systemic
1.9
6.8
131
861
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.9
6.8
32
117
Z3231
NOMESCO Finland
Registered nurse
2.0
6.6
94
557
J45.8
ICD-10 Finland
Mixed asthma
4.2
6.4
17
42
M54.5
ICD-10 Finland
Low back pain
1.8
6.4
127
838
M79.6
ICD-10 Finland
Pain in limb
1.8
6.4
143
980
SPAT1283
SPAT
Restricted health certificate
2.0
6.4
87
508
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.8
6.3
200
1521
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
6.3
125
826
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
2.3
6.3
52
251
JEA00
NOMESCO Finland
Appendectomy
3.0
6.2
27
94
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.4
6.2
44
198
ZXE00
NOMESCO Finland
One hour or less
1.8
6.2
129
864
B07.9
ICD-10 Finland
Verruca simplex
3.7
6.1
19
53
TQW80
NOMESCO Finland
Local dermatologic skincare
6.9
6.1
14
21
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.7
6.1
34
136
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
6.1
84
492
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.1
6.0
68
370
P01BA02
ATC
hydroxychloroquine; oral
2.7
6.0
33
131

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
104
388
3.47
22.50
1.6
1.4
448.57
520.00
titre
0.25
28
86
208
1317
2.62
15.29
7.2
5.4
0.04
0.04
e9/l
0.12
183
1143
213
1367
2.63
15.18
7.2
5.9
0.19
0.18
e9/l
0.45
190
1201
207
1315
2.59
15.00
7.2
5.4
0.52
0.54
e9/l
0.98
184
1144
212
1366
2.60
14.84
7.2
5.3
1.98
2.04
e9/l
0.28
191
1217
189
1185
2.43
13.57
7.1
5.4
0.67
0.70
%
0.35
178
1109
262
1934
2.85
12.91
5.2
3.8
9.57
9.83
mm/h
0.15
256
1790
194
1248
2.38
12.90
7.2
5.8
—
—
—
0
0
196
1269
2.38
12.80
7.0
5.2
55.38
55.95
%
0.33
186
1204
197
1279
2.38
12.77
7.2
5.3
30.08
29.86
%
0.13
188
1212
191
1229
2.35
12.57
7.2
5.3
2.96
2.74
%
0.67
181
1154
192
1240
2.35
12.50
7.4
5.6
8.10
8.22
%
0.28
182
1169
218
1521
2.32
11.36
9.2
8.9
3.83
3.96
e9/l
0.44
194
1329
95
531
2.12
8.07
1.4
1.3
29.65
29.45
iu/ml
0.01
26
173
78
410
2.19
7.71
2.7
2.4
46.21
114.73
ug/g
3.46
65
319
294
2517
2.82
7.22
5.4
4.7
1.70
2.28
mu/l
0.65
285
2344
39
154
2.74
7.16
1.5
1.8
1.49
1.46
g/l
0.04
39
146
21
59
3.74
6.71
1.3
1.0
3.19
2.79
u/ml
0.07
15
29
98
590
1.95
6.61
2.3
2.5
317.23
6010.22
umol/l
2.48
90
520
105
649
1.91
6.54
2.1
2.1
133.29
294.70
u/l
0.87
99
615
238
1903
1.94
6.47
7.9
6.9
71.87
76.40
u/l
1.29
230
1785
181
1329
1.82
6.46
3.3
2.7
114.68
85.31
ug/l
1.25
171
1245
89
523
1.97
6.42
1.3
1.3
7.36
8.05
u/ml
0.07
42
200
70
379
2.08
6.32
2.8
2.5
2.44
2.44
mmol/l
0.06
64
332
52
251
2.28
6.25
1.5
1.2
94.36
184.68
iu/ml
1.03
14
111
260
2159
2.03
6.11
4.7
4.0
14.40
14.48
pmol/l
0.24
249
1982
101
630
1.88
6.05
1.4
1.4
2.56
2.11
g/l
1.07
73
400
102
643
1.86
5.89
7.5
6.8
—
—
—
0
0
52
267
2.13
5.36
1.4
1.4
—
—
—
0
0
12
18
6.88
5.30
1.4
1.4
0.12
0.17
u/ml
—
7
7
15
40
3.88
5.15
1.1
1.0
0.06
0.62
u/ml
—
9
9
54
287
2.06
5.08
1.8
2.4
6.34
7.32
umol/l
0.21
47
247
149
1086
1.69
5.04
2.9
2.3
72.10
75.41
nmol/l
0.70
143
993
37
177
2.23
4.54
1.4
1.2
—
—
—
0
0
15
44
3.53
4.52
1.0
1.1
—
—
—
0
0
24
94
2.68
4.50
1.2
1.1
—
—
—
0
0
266
2304
1.86
4.46
4.6
4.6
37.23
38.53
mmol/mol
2.16
258
2179
157
1188
1.62
4.41
9.5
7.8
0.00
0.00
e9/l
0.56
129
956
124
889
1.64
4.30
2.1
1.8
101.72
98.60
pmol/l
0.28
63
451
218
1796
1.65
4.28
4.8
3.9
—
—
—
0
0
20
73
2.85
4.27
1.2
1.1
3.44
3.24
u/ml
0.04
14
39
36
175
2.19
4.25
4.0
4.4
0.00
0.06
%
—
7
49
37
182
2.17
4.25
1.9
2.5
24393.58
3047.88
u/l
1.01
12
79
15
46
3.37
4.24
1.3
1.2
—
—
—
0
0
143
1067
1.61
4.20
2.2
2.0
—
—
—
0
0
130
948
1.62
4.19
4.4
4.1
37.77
36.80
g/l
1.33
123
900
104
722
1.65
4.06
1.3
1.3
0.60
1.04
u/ml
1.49
26
201
119
858
1.61
3.98
3.6
3.1
32.08
55.39
e6/l
0.66
85
578
299
2722
2.28
3.96
14.9
10.7
18.21
20.16
mg/l
0.52
242
2047
51
291
1.89
3.91
2.2
2.1
26.07
25.10
%
0.19
45
253
94
645
1.64
3.81
2.7
2.6
0.20
0.33
e6/l
0.48
72
467
88
595
1.66
3.77
2.3
2.0
2.62
2.86
mg/l
0.43
75
505
109
778
1.60
3.76
2.5
2.9
2.37
2.36
mmol/l
0.14
99
700
35
178
2.08
3.70
4.0
3.9
0.14
0.47
%
—
7
55
61
375
1.77
3.68
4.3
3.3
60.52
385.80
ng/l
0.98
33
239
53
313
1.83
3.65
1.2
1.2
—
—
—
0
0
101
716
1.60
3.56
2.8
2.6
17.18
54.83
e6/l
1.91
79
534
20
81
2.57
3.54
1.5
1.7
—
—
—
0
0
17
65
2.70
3.36
1.1
1.1
11.51
6.00
u/ml
—
10
36
53
322
1.77
3.33
2.2
2.0
2.38
2.45
g/l
0.40
46
301
36
193
1.97
3.31
4.0
4.2
0.57
0.72
%
—
7
67
276
2486
1.74
3.18
3.9
3.8
5.73
5.73
mmol/l
0.03
268
2307
91
648
1.56
3.09
2.6
2.5
—
—
—
0
0
16
62
2.66
3.09
1.4
1.3
—
—
—
0
0
97
704
1.54
3.02
2.8
2.5
—
—
—
0
0
17
70
2.51
2.93
2.2
2.4
—
—
—
0
0
12
38
3.24
2.88
1.0
1.1
—
—
—
0
0
15
60
2.57
2.74
1.1
1.1
0.67
0.61
u/ml
—
8
25
104
781
1.49
2.73
2.9
3.0
21.41
28.16
ng/l
0.33
43
436
59
390
1.63
2.72
1.4
1.5
—
—
—
0
0
81
578
1.54
2.70
2.3
1.6
0.95
0.80
mg/l
0.35
58
434
17
73
2.40
2.70
1.1
1.3
—
4.17
—
0
12
195
1654
1.45
2.68
3.2
3.1
—
—
—
0
0
15
61
2.53
2.66
1.0
1.3
275.49
238.82
u/ml
—
10
33
36
209
1.81
2.63
1.9
2.7
1.68
1.78
%
0.33
36
187
7
15
4.74
2.61
1.3
1.7
70.00
68.87
umol/l
—
7
15
12
44
2.79
2.57
1.1
1.0
9.90
6.86
u/ml
—
6
14
165
1371
1.41
2.46
4.4
3.8
6.32
6.45
mmol/l
0.40
159
1246
18
83
2.24
2.46
1.1
1.2
—
—
—
0
0
27
146
1.93
2.46
1.6
2.7
75.76
72.93
e9/l
0.15
19
106
6
12
5.07
2.41
1.0
1.1
—
—
—
0
0
9
27
3.40
2.41
1.1
1.2
—
—
—
0
0
25
135
1.92
2.29
1.2
1.3
—
—
—
0
0
8
23
3.54
2.28
1.0
1.1
—
—
—
0
0
6
13
4.68
2.28
1.0
1.1
—
—
—
0
0
99
760
1.44
2.27
1.9
2.0
—
—
—
0
0
318
3073
2.88
2.21
21.2
16.1
40.67
40.47
%
0.26
304
2913
6
14
4.34
2.16
1.5
1.7
3.23
2.84
mg/l
—
6
14
23
124
1.92
2.13
1.7
1.2
—
—
—
0
0
89
678
1.43
2.11
2.4
3.4
7.39
7.40
ph
0.22
14
111
6
15
4.05
2.05
1.0
1.3
1.68
1.86
mmol/l
—
6
15
136
1121
1.37
2.02
5.0
5.7
1.22
1.22
mmol/l
0.02
122
973
7
21
3.38
1.97
2.0
1.9
1.13
1.69
e9/l
—
7
16
60
430
1.49
1.94
1.7
1.6
415.17
13513955.37
pmol/l
0.50
54
370
6
16
3.80
1.94
4.0
3.3
592.67
792.19
u/ml
—
6
16
13
58
2.29
1.93
1.0
1.2
—
—
—
0
0
95
748
1.38
1.84
3.1
2.3
57.44
58.28
u/l
0.09
87
700
6
17
3.58
1.84
1.8
2.2
38.30
38.31
%
—
6
17
67
501
1.43
1.75
1.4
1.4
19.70
22.03
nmol/l
0.74
61
430
7
24
2.96
1.73
2.0
3.0
—
—
—
0
0
50
357
1.47
1.66
2.4
2.5
1.36
3.06
e6/l
1.82
25
183
49
349
1.48
1.64
1.7
1.7
1149.45
1156.29
nmol/l
0.02
39
260
10
42
2.42
1.63
1.0
1.4
—
—
—
0
0
5
14
3.61
1.62
1.0
1.1
1980.00
1714.14
miu/ml
—
5
14
22
129
1.76
1.61
1.1
1.1
—
—
—
0
0
209
1876
1.32
1.60
2.7
2.9
39.82
38.33
u/l
0.13
203
1781
7
26
2.73
1.59
1.4
1.7
—
—
—
0
0
147
1259
1.31
1.59
4.7
4.3
0.00
0.00
estimate
0.50
35
251
6
20
3.04
1.59
2.0
1.8
0.33
0.17
e9/l
—
6
15
148
1272
1.30
1.55
3.6
3.1
0.00
0.00
estimate
-0.00
33
243
5
15
3.37
1.53
1.4
1.3
187.38
110.45
iu/ml
—
5
15
5
15
3.37
1.53
1.0
1.1
—
—
—
0
0
78
613
1.36
1.52
1.7
1.7
—
—
—
0
0
9
37
2.47
1.49
2.7
2.1
—
—
—
0
0
28
180
1.61
1.48
1.4
1.4
26.01
24.13
iu/l
0.09
21
150
14
73
1.96
1.46
1.1
1.3
454.64
392.34
mg/l
0.56
14
68
5
16
3.16
1.44
1.2
1.2
—
—
—
0
0
6
22
2.76
1.44
3.8
2.7
26.43
19.03
mu/l
—
6
22
146
1262
1.29
1.43
3.7
3.1
0.00
0.00
estimate
-0.00
36
260
26
166
1.62
1.42
1.2
1.1
—
—
—
0
0
111
927
1.30
1.41
15.4
9.4
1.19
1.11
inr
0.48
44
274
9
40
2.28
1.41
4.1
2.3
39.78
32.29
umol/l
—
9
35
123
1042
1.29
1.41
3.3
2.9
5.62
5.94
ph
0.64
16
89
15
82
1.87
1.38
2.2
1.8
20.50
20.64
s
—
10
70
9
41
2.23
1.38
2.1
4.6
3.87
4.21
e9/l
—
9
41
83
668
1.33
1.38
4.1
3.3
0.00
0.01
estimate
0.80
35
246
6
23
2.64
1.37
2.2
2.1
637.83
708.70
e6/l
—
6
23
6
23
2.64
1.37
1.8
1.5
35.00
32.65
pg
—
6
23
40
285
1.46
1.36
1.6
1.4
—
—
—
0
0
9
42
2.17
1.34
2.2
4.8
55.67
55.88
%
—
9
42
28
185
1.56
1.34
3.4
3.1
—
—
—
0
0
276
2607
1.40
1.33
4.6
4.1
3.01
2.85
mmol/l
2.18
270
2443
6
24
2.53
1.31
1.3
2.0
—
—
—
0
0
119
1012
1.28
1.30
4.1
4.9
1.22
1.22
mmol/l
0.04
111
942
12
62
1.97
1.29
1.1
1.4
—
—
—
0
0
273
2578
1.37
1.28
4.3
3.8
4.89
4.77
mmol/l
1.17
267
2427
9
44
2.07
1.28
1.2
1.1
—
—
—
0
0
8
35
2.32
1.27
1.3
1.1
—
—
—
0
0
34
239
1.47
1.24
1.2
1.4
—
—
—
0
0
75
606
1.31
1.21
2.8
3.3
—
—
—
0
0
11
57
1.96
1.18
2.2
1.8
—
—
—
0
0
11
58
1.93
1.13
1.0
1.1
—
—
—
0
0
11
58
1.93
1.13
1.0
1.1
—
—
—
0
0
35
254
1.42
1.10
1.1
1.1
—
—
—
0
0
8
41
1.97
1.09
1.5
2.7
234.88
5.82
u/ml
—
8
41
5
21
2.40
1.09
1.0
1.1
—
—
—
0
0
22
146
1.54
1.06
1.7
2.3
68.57
67.52
g/l
0.31
22
134
68
560
1.27
0.95
3.8
3.1
—
—
—
0
0
9
52
1.75
0.93
2.3
4.2
3.68
3.85
mmol/l
—
9
52
6
28
2.16
0.92
1.0
1.1
—
—
—
0
0
269
2569
1.28
0.89
4.2
3.8
1.47
1.50
mmol/l
0.70
261
2415
259
2463
1.26
0.89
3.9
3.4
1.40
1.25
mmol/l
2.34
250
2308
6
30
2.02
0.87
1.0
1.3
—
—
—
0
0
37
284
1.34
0.87
1.5
1.3
—
—
—
0
0
24
171
1.44
0.86
1.3
1.2
—
—
—
0
0
10
57
1.78
0.84
1.4
1.1
—
—
—
0
0
18
122
1.50
0.82
1.6
2.1
—
—
—
0
0
85
731
1.22
0.82
3.0
2.7
—
—
—
0
0
6
34
1.78
0.76
1.2
1.4
—
—
—
0
0
6
34
1.78
0.76
1.0
1.4
—
—
—
0
0
9
54
1.69
0.75
1.3
2.0
—
—
—
0
0
295
2864
1.34
0.75
10.6
10.1
—
—
—
0
0
20
142
1.44
0.74
1.7
1.3
134.03
281.21
miu/ml
—
9
67
5
25
2.02
0.73
2.4
2.0
—
—
—
0
0
14
93
1.53
0.70
1.2
1.2
—
—
—
0
0
9
59
1.54
0.69
1.0
1.3
—
—
—
0
0
9
59
1.54
0.69
2.0
1.9
—
—
—
0
0
5
27
1.86
0.68
1.0
1.1
—
—
—
0
0
15
103
1.48
0.66
9.5
8.3
0.55
0.69
%
1.11
15
103
15
103
1.48
0.66
1.5
1.7
—
—
—
0
0
5
29
1.74
0.64
1.6
1.3
—
—
—
0
0
15
104
1.46
0.63
9.5
8.3
1.20
1.47
%
0.56
15
104
57
485
1.21
0.62
1.7
1.7
—
—
—
0
0
5
30
1.68
0.61
1.0
1.4
—
—
—
0
0
8
52
1.55
0.60
1.9
1.5
188.38
241.98
pmol/l
—
8
47
40
329
1.25
0.59
1.5
1.9
—
—
—
0
0
17
123
1.40
0.59
2.7
2.9
217.50
127.13
ng/l
0.24
12
113
0
23
0.00
0.58
0.0
2.3
—
—
—
0
0
19
141
1.37
0.58
1.8
2.2
—
—
—
0
0
6
36
1.68
0.57
1.0
1.2
—
—
—
0
0
89
795
1.16
0.56
2.1
2.1
—
—
—
0
0
75
665
1.17
0.52
1.7
1.6
1.64
1.38
mmol/l
1.05
70
589
24
190
1.28
0.49
1.3
1.3
—
—
—
0
0
11
76
1.46
0.48
2.8
3.6
123.36
116.78
u/ml
0.02
11
67
25
200
1.27
0.48
2.8
2.3
0.63
0.67
ug/l
0.09
13
114
33
275
1.22
0.46
1.3
1.5
—
—
—
0
0
41
350
1.20
0.45
1.7
1.8
—
—
—
0
0
7
51
1.38
0.44
2.1
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
5.44
—
0
16
5
34
1.48
0.40
2.0
3.0
—
—
—
0
0
15
193
0.77
0.40
1.8
1.8
—
—
—
0
0
10
137
0.72
0.40
2.5
3.0
—
—
—
0
0
15
115
1.32
0.39
7.5
6.6
24.25
25.33
mmol/l
0.77
15
115
0
19
0.00
0.39
0.0
1.0
—
—
—
0
0
21
171
1.24
0.36
1.3
1.5
—
—
—
0
0
35
302
1.18
0.35
3.7
1.9
31.47
29.13
s
1.11
35
294
6
42
1.44
0.35
1.8
1.7
13.33
13.19
%
—
6
42
110
1028
1.11
0.35
2.4
2.5
—
—
—
0
0
6
44
1.37
0.34
1.7
1.4
—
—
—
0
0
24
201
1.21
0.33
1.7
1.7
—
—
—
0
0
130
1232
1.09
0.30
2.5
2.4
—
—
—
0
0
19
159
1.21
0.27
7.7
7.6
121.11
122.79
g/l
0.20
19
154
19
225
0.83
0.27
1.4
1.4
—
—
—
0
0
14
114
1.24
0.25
3.1
2.4
0.01
0.11
e6/l
2.53
14
107
13
105
1.25
0.25
2.5
2.0
—
—
—
0
0
7
91
0.76
0.23
15.9
7.8
—
—
—
0
0
10
79
1.27
0.22
11.0
7.8
—
—
—
0
0
5
41
1.22
0.22
1.4
2.0
—
—
—
0
0
48
520
0.91
0.21
3.6
3.9
—
—
—
0
0
29
260
1.13
0.20
4.4
5.0
1.10
1.06
mmol/l
0.45
24
241
17
196
0.86
0.19
1.7
2.0
—
—
—
0
0
16
185
0.86
0.18
1.7
2.0
—
—
—
0
0
17
195
0.86
0.18
1.7
2.0
—
—
—
0
0
17
195
0.86
0.18
1.7
2.0
—
—
—
0
0
18
204
0.88
0.16
4.6
4.5
5.57
28.88
ug/l
0.54
11
160
14
162
0.86
0.16
1.7
2.1
—
—
—
0
0
8
72
1.11
0.16
3.5
4.8
—
—
—
0
0
6
80
0.75
0.15
1.3
1.2
—
—
—
0
0
14
122
1.15
0.14
1.8
1.4
—
—
—
0
0
14
122
1.15
0.14
1.8
1.4
—
—
—
0
0
25
228
1.10
0.13
3.8
3.1
—
—
—
0
0
23
210
1.10
0.12
3.0
4.2
—
—
—
0
0
60
574
1.06
0.11
3.1
3.3
52.23
55.72
mg/l
0.04
39
363
12
106
1.14
0.10
2.2
4.5
—
—
—
0
0
14
126
1.12
0.09
1.9
1.5
—
—
—
0
0
6
55
1.09
0.09
1.0
1.7
4.08
4.81
mmol/24h
—
6
44
72
697
1.04
0.09
2.7
3.1
7.48
7.78
mmol/l
0.25
65
601
17
156
1.09
0.08
6.1
5.7
6.87
7.73
mmol/l
0.27
17
151
46
442
1.05
0.07
1.8
1.5
—
—
—
0
0
82
841
0.97
0.07
1.8
1.6
—
—
—
0
0
59
573
1.04
0.06
4.2
3.2
1.02
1.02
kg/l
—
7
69
11
100
1.10
0.05
3.6
3.8
—
—
—
0
0
36
373
0.96
0.05
1.3
1.3
—
—
—
0
0
23
220
1.05
0.03
7.7
6.2
105.26
104.53
mmol/l
0.43
23
220
17
161
1.06
0.03
9.4
6.9
—
—
—
0
0
59
599
0.98
0.02
3.6
4.0
9.37
10.20
mg/mmol
0.05
41
374
10
93
1.08
0.02
1.7
2.7
—
—
—
0
0
32
328
0.97
0.02
1.4
1.2
—
—
—
0
0
13
128
1.02
0.00
3.7
3.8
—
7.41
—
0
8
11
113
0.97
0.00
3.7
7.3
24.85
25.03
mmol/l
0.06
11
107
19
194
0.98
0.00
3.3
3.2
—
—
—
0
0
9
97
0.93
0.00
1.8
2.6
0.47
0.64
%
—
9
97
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
6
67
0.89
-0.00
2.7
5.5
1.68
1.17
mmol/l
—
6
57
0
7
0.00
-0.00
0.0
4.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
6.19
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
1.21
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.1
—
—
—
0
0
6
66
0.91
-0.00
1.5
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
1.65
—
0
6
10
100
1.00
-0.00
1.7
2.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.8
—
41.40
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
19
190
1.00
-0.00
2.9
3.2
5.95
5.75
kpa
0.56
19
185
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint L12_URTICA_COLDHEAT and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_URTICA_COLDHEAT.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

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Index endpoint: L12_URTICA_COLDHEAT – Urticaria due to cold and heat

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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