No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
475 |
4. Check minimum number of eventsNone |
475 |
5. Include endpointsNone |
475 |
6. Filter based on genotype QC (FinnGen only) |
475 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M24
- Name in latin
- Contractura articulationis
Similar endpoints
↥List of similar endpoints to
Contracture of joint
based on the number of shared cases.
Similar with more cases:
- Other joint disorders
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4443 | 2087 | 2306 |
| Only index persons | 3699 | 1819 | 1880 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.06 |
| Only index persons | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 50.49 | 51.25 | 49.64 |
| Only index persons | 48.48 | 50.18 | 46.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 475 | 249 | 226 |
| Unadjusted period prevalence (%) | 0.09 | 0.08 | 0.10 |
| Median age at first event (years) | 49.62 | 47.23 | 52.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 423
- Matched controls
- 4231
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M24.5
ICD-10 Finland
Contracture of joint
+∞
323.0
280
*
72900
ICD-8 Finland
Other diseases of joint, Contractura articuli
+∞
93.2
86
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
30.6
82.8
112
49
M19.0
ICD-10 Finland
Primary arthrosis of other joints
69.5
61.8
70
12
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
55.4
52
*
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
42.1
42.0
52
14
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
16.9
40.1
65
45
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
116.2
39.5
42
*
ZXA05
NOMESCO Finland
Left side
4.7
37.1
153
456
M25.5
ICD-10 Finland
Pain in joint
5.3
37.0
129
321
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
376.7
35.5
35
*
ZXA00
NOMESCO Finland
Right side
4.0
30.8
151
515
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
10.8
29.5
58
61
N02AX02
ATC
tramadol; systemic, rectal
3.3
29.1
205
927
M16.1
ICD-10 Finland
Other primary coxarthrosis
39.6
26.5
33
9
X59
ICD-10 Finland
Exposure to unspecified factor
4.3
26.1
108
309
NGT60
NOMESCO Finland
Forcible manipulation of knee joint
276.4
26.0
26
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.1
26.0
209
1014
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
+∞
24.2
23
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
8.6
23.1
51
66
NBT60
NOMESCO Finland
Forcible manipulation of humeroscapular joint
18.9
23.0
35
20
1220
FHL
Arthroscopy
19.7
22.1
33
18
72410
ICD-8 Finland
Internal derangement of joint, Other shoulder derangement
+∞
22.1
21
*
M75.1
ICD-10 Finland
Rotator cuff syndrome
3.4
20.6
116
423
R4110
NOMESCO Finland
Physiotherapy
3.1
20.4
137
563
NDE60
NOMESCO Finland
Incision and release of adhesions in joint of finger or metacarpal
+∞
19.9
19
*
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
+∞
19.9
19
*
WX320
NOMESCO Finland
Spinalanesthesy
3.8
19.9
94
297
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.9
19.4
145
638
S18
ICPC
Laceration/cut
2.7
19.3
179
902
M01AX05
ATC
glucosamine; oral
4.2
19.1
79
221
N02BE01
ATC
paracetamol; systemic, rectal
3.1
18.7
356
2678
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
6.6
18.7
49
82
N03AX16
ATC
pregabalin; oral
3.2
18.6
111
418
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
8.2
18.6
42
56
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
8.7
18.0
39
49
B01AB05
ATC
enoxaparin; parenteral
2.9
17.8
130
558
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
30.3
17.6
23
8
L90
ICPC
Osteoarthrosis of knee
14.1
17.2
29
22
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
6.7
16.7
43
70
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
176.6
16.6
17
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
176.6
16.6
17
*
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
7.2
16.5
40
60
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
12.4
16.3
29
25
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
19.5
16.2
24
13
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
34.8
15.9
20
6
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
165.8
15.6
16
*
M79.6
ICD-10 Finland
Pain in limb
2.6
15.3
142
697
M01AH05
ATC
etoricoxib; oral
2.3
15.2
223
1376
R4120
NOMESCO Finland
Occupational therapy
5.9
15.1
43
80
M72.0
ICD-10 Finland
Palmar fascial fibromatosis [Dupuytren]
6.6
15.1
39
64
NCF25
NOMESCO Finland
Operation for osteochondritis of elbow joint, arthroscopic
58.8
14.9
17
*
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
83.0
14.7
16
*
7184D
ICD-9 Finland
Other derangement of joint, Contracture of joint[CONTRACTURA, KÄSI]
+∞
14.7
14
*
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
6.1
14.6
40
71
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
5.8
14.3
41
77
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.1
14.0
56
151
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.8
13.9
101
423
L15
ICPC
Knee symptom/complaint
3.2
13.9
78
277
7184F
ICD-9 Finland
Other derangement of joint, Contracture of joint[CONTRACTURA, POLVI]
+∞
13.6
13
*
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
5.7
13.5
39
74
M17.5
ICD-10 Finland
Other secondary gonarthrosis
144.3
13.5
14
*
M13.9
ICD-10 Finland
Arthritis, unspecified
9.5
13.4
27
30
N02AJ06
ATC
codeine and paracetamol; systemic
2.4
13.2
134
681
NDM10
NOMESCO Finland
Palmar fasciotomy of hand
8.5
13.0
28
35
X58
ICD-10 Finland
Exposure to other specified factors
3.4
13.0
67
223
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
51.6
12.9
15
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
12.7
125
623
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
12.6
12
*
M23.8
ICD-10 Finland
Other internal derangements of knee
18.7
12.1
18
10
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.4
12.1
44
108
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
4.9
12.1
40
89
9253
FHL
Manipulation under anesthesia or regression and plastering
22.0
12.1
17
8
WX702
NOMESCO Finland
Supraglottic ventilation device
5.0
12.0
38
81
NBE15
NOMESCO Finland
Incision or suture of capsule of joint of shoulder, arthroscopic
48.1
11.9
14
*
M20.1
ICD-10 Finland
Hallux valgus (acquired)
11.0
11.9
22
21
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
15.2
11.9
19
13
L28
ICPC
Limited function/disability (L)
3.2
11.7
64
221
NG1DA
NOMESCO Finland
X-ray of knees
+∞
11.5
11
*
NDL54
NOMESCO Finland
Tenolysis of hand
+∞
11.5
11
*
7184E
ICD-9 Finland
Other derangement of joint, Contracture of joint[CONTRACTURA, LONKKANIVEL]
+∞
11.5
11
*
WX200
NOMESCO Finland
Interscalenous plexus blockade
12.3
11.4
20
17
M01AB05
ATC
diclofenac; systemic, rectal
2.1
11.4
264
1891
G56.2
ICD-10 Finland
Lesion of ulnar nerve
11.0
11.4
21
20
M09AX01
ATC
hyaluronic acid; parenteral
10.0
11.4
22
23
J01DA01
ATC
[U] cefalexin; systemic
2.0
11.0
261
1876
M22.4
ICD-10 Finland
Chondromalacia patellae
44.5
11.0
13
*
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
11.0
10.9
20
19
WX110
NOMESCO Finland
Local anesthesy
2.0
10.6
272
2000
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.0
10.6
65
244
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.1
10.6
153
896
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
7.1
10.5
25
37
WX203
NOMESCO Finland
Infraclavicular plexus blockade
9.9
10.4
20
21
M01AE03
ATC
ketoprofen; systemic, rectal
2.1
10.3
158
947
H02AB06
ATC
prednisolone; systemic
2.0
10.3
177
1110
N03AX12
ATC
gabapentin; oral
3.0
10.2
61
223
P01BA02
ATC
hydroxychloroquine; oral
6.1
10.1
27
47
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
10.0
142
823
S62.6
ICD-10 Finland
Fracture of other finger
5.1
10.0
31
65
J01FF01
ATC
clindamycin; systemic
2.3
10.0
109
563
M01AC06
ATC
meloxicam; systemic, rectal
2.1
9.9
136
773
M54.5
ICD-10 Finland
Low back pain
2.1
9.8
129
724
B01AF01
ATC
rivaroxaban; oral
4.0
9.7
38
101
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
15.5
9.6
15
10
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
102.2
9.4
10
*
WX111
NOMESCO Finland
Local infiltration anesthesia
102.2
9.4
10
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
8.3
9.4
20
25
WX002
NOMESCO Finland
Sedation and analgesia
2.5
9.4
77
343
71301
ICD-8 Finland
Osteo-arthritis and allied conditions, Arthritis (arthrosis) genus
+∞
9.4
9
*
A02BC02
ATC
pantoprazole; systemic
1.9
9.4
249
1812
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.2
9.3
50
172
A07EC01
ATC
sulfasalazine; oral, rectal
5.7
9.0
25
46
L08
ICPC
Shoulder symptom/complaint
2.5
9.0
72
316
S83.2
ICD-10 Finland
Tear of meniscus, current
4.4
8.9
31
74
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.5
8.8
71
313
NBG00
NOMESCO Finland
Plastic operation on acromioclavicular joint
51.0
8.7
10
*
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
51.0
8.7
10
*
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
7.6
8.5
19
26
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
8.5
108
589
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.0
8.5
50
183
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
91.8
8.4
9
*
M01AH01
ATC
celecoxib; oral (coxibs)
2.5
8.4
66
287
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
+∞
8.4
8
*
M24.4
ICD-10 Finland
Recurrent dislocation and subluxation of joint
+∞
8.4
8
*
ND1AA
NOMESCO Finland
Wrist X-ray examination
4.4
8.3
29
70
S83.5
ICD-10 Finland
Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
6.3
8.2
21
35
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
7.8
8.2
18
24
QCB10
NOMESCO Finland
Major dressing of wound of skin of upper limb
7.8
8.2
18
24
Z50.1
ICD-10 Finland
Other physical therapy
4.7
8.2
27
61
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
5.0
8.2
25
52
J01DB01
ATC
cefalexin; oral
1.9
8.1
320
2606
R07.4
ICD-10 Finland
Chest pain, unspecified
2.1
8.1
102
555
A04
ICPC
Weakness/tiredness general
2.8
8.1
54
213
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
5.7
8.1
22
40
WX212
NOMESCO Finland
Femoral plexus blockade
10.3
8.1
15
15
M01AE02
ATC
naproxen; oral, rectal
1.8
8.0
212
1509
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
4.4
7.9
27
64
M01AH02
ATC
rofecoxib; oral
2.9
7.8
48
180
1225
FHL
Arthroscopy and other therapeutic procedure
45.8
7.7
9
*
J01AA02
ATC
doxycycline; systemic
1.9
7.7
309
2504
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.3
7.7
37
118
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
18.8
7.6
11
6
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
4.6
7.6
25
57
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
7.6
155
1011
J01MA02
ATC
ciprofloxacin; systemic
1.8
7.4
149
963
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
3.5
7.3
33
100
M79.0
ICD-10 Finland
Rheumatism, unspecified
6.4
7.3
18
29
M19.2
ICD-10 Finland
Other secondary arthrosis
+∞
7.3
7
*
7184A
ICD-9 Finland
Other derangement of joint, Contracture of joint[CONTRACTURA, OLKANIVEL]
+∞
7.3
7
*
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
+∞
7.3
7
*
1222
FHL
Arthroscopy and synovial surgery
+∞
7.3
7
*
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
+∞
7.3
7
*
M01AE01
ATC
ibuprofen; systemic, rectal
2.0
7.2
351
3001
NBE45
NOMESCO Finland
Plastic repair of ligament of shoulder not using prosthetic material, arthroscopic
30.6
7.2
9
*
M01AX17
ATC
nimesulide; oral
2.1
7.1
90
489
S83.0
ICD-10 Finland
Dislocation of patella
12.3
7.1
12
10
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.4
7.1
33
103
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
10.3
7.1
13
13
M19.8
ICD-10 Finland
Other specified arthrosis
7.2
7.1
16
23
W19
ICD-10 Finland
Unspecified fall
2.8
7.0
44
166
NGE35
NOMESCO Finland
Plastic repair of ligament of knee not using prosthetic material, anterior cruciate, arthroscopic
7.7
7.0
15
20
M25.4
ICD-10 Finland
Effusion of joint
14.1
6.9
11
8
SPAT1153
SPAT
Removal of sutures
1.9
6.8
111
661
M25.6
ICD-10 Finland
Stiffness of joint, not elsewhere classified
40.7
6.8
8
*
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
17.0
6.8
10
6
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.4
6.8
56
251
M24.2
ICD-10 Finland
Disorder of ligament
22.9
6.7
9
*
S30.0
ICD-10 Finland
Contusion of lower back and pelvis
5.6
6.7
18
33
M16.9
ICD-10 Finland
Coxarthrosis, unspecified
6.1
6.7
17
29
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.7
6.6
203
1480
NBF25
NOMESCO Finland
Operation for humeroscapular osteochondritis, arthroscopic
8.9
6.6
13
15
NF1AA
NOMESCO Finland
Hip X-ray examination
4.0
6.5
24
62
C03CA01
ATC
furosemide; systemic
1.9
6.5
107
643
SPAT1229
SPAT
Assessment of need for aid
3.4
6.5
30
94
M22.0
ICD-10 Finland
Recurrent dislocation of patella
70.8
6.4
7
*
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
70.8
6.4
7
*
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
70.8
6.4
7
*
L04AA13
ATC
leflunomide; oral
70.8
6.4
7
*
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
70.8
6.4
7
*
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
3.6
6.4
27
78
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.5
6.4
50
215
NB1CG
NOMESCO Finland
Shoulder and humerus extensive MRI examination with high intensity magnet
8.3
6.4
13
16
E66.01
ICD-10 Finland
Obesity due to excess calories
3.3
6.3
30
96
SAA01
NOMESCO Finland
Simple examination of mouth
1.7
6.3
257
2024
N06AX21
ATC
duloxetine; oral
2.8
6.3
40
154
7177A
ICD-9 Finland
Internal derangement of knee, Chondromalacia of patella
+∞
6.3
6
*
NGH99
NOMESCO Finland
Other operation on knee joint, unspecified
+∞
6.3
6
*
M00.9
ICD-10 Finland
Pyogenic arthritis, unspecified
+∞
6.3
6
*
NGE10
NOMESCO Finland
Incision or suture of capsule of knee joint
+∞
6.3
6
*
NGE60
NOMESCO Finland
Plastic repair of patellar ligaments, open
+∞
6.3
6
*
M25.2
ICD-10 Finland
Flail joint
+∞
6.3
6
*
7184B
ICD-9 Finland
Other derangement of joint, Contracture of joint[CONTRACTURA, KYYNÄRNIVEL]
+∞
6.3
6
*
T92.1
ICD-10 Finland
Sequelae of fracture of arm
27.1
6.2
8
*
M65.3
ICD-10 Finland
Trigger finger
4.6
6.2
20
45
L84
ICD-10 Finland
Corns and callosities
5.5
6.2
17
32
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.7
6.2
178
1269
R52.9
ICD-10 Finland
Pain, unspecified
3.1
6.2
32
109
E883A
ICD-9 Finland
Fall into hole or other opening in surface
3.6
6.1
26
76
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
5.0
6.1
18
37
M67.8
ICD-10 Finland
Other specified disorders of synovium and tendon
12.8
6.1
10
8
L12
ICPC
Hand/finger symptom/complaint
2.5
6.1
48
208
A02BC05
ATC
esomeprazole; systemic
1.7
6.1
145
976
N06AA09
ATC
amitriptyline; systemic
2.7
6.0
40
159
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
333
2413
2.27
14.85
4.5
3.2
12.5
11.6
mm/h
0.47
318
2201
87
424
2.29
10.06
1.4
1.2
409.3
14.6
iu/ml
0.50
27
131
82
392
2.32
9.91
1.4
1.1
1.9
1.3
u/ml
0.40
23
172
15
22
7.01
9.78
1.5
1.1
2490.3
11186.2
e6/l
—
9
16
207
1402
1.84
9.47
3.7
4.7
35.3
35.5
g/l
0.15
198
1309
130
759
1.98
9.34
2.6
2.2
6969.5
9078.9
umol/l
0.17
112
656
338
2671
1.92
9.32
7.2
6.9
80.4
78.5
u/l
0.33
327
2509
213
1477
1.80
8.85
4.1
3.9
—
—
—
0
0
15
26
5.92
8.37
1.3
1.0
—
—
—
0
0
119
708
1.91
7.95
1.6
1.5
1.3
1.3
mg/l
0.00
88
530
112
658
1.92
7.75
4.1
3.7
176.4
436.3
ng/l
1.07
81
495
406
3512
2.07
7.37
17.5
12.5
24.7
25.8
mg/l
0.26
346
2686
140
896
1.80
7.35
3.1
2.8
0.4
0.5
e6/l
0.50
107
655
95
538
1.96
7.30
2.7
2.5
1.0
1.1
e6/l
0.16
61
286
63
309
2.20
7.10
3.3
2.2
37.9
39.4
u/l
0.07
51
256
222
1637
1.67
6.88
6.5
6.6
1.2
1.2
mmol/l
0.23
197
1378
185
1301
1.69
6.87
2.2
1.9
97.2
94.8
pmol/l
0.32
107
682
203
1483
1.64
6.39
6.6
5.7
1.2
1.2
mmol/l
0.33
195
1345
90
523
1.89
6.36
2.8
2.6
2.3
2.3
e6/l
0.01
56
275
145
977
1.70
6.20
2.2
2.1
135.0
306.8
u/l
1.50
136
916
250
1944
1.60
5.97
6.5
9.0
4.2
4.1
e9/l
0.18
220
1679
15
37
4.15
5.67
1.7
1.3
—
—
—
0
0
168
1202
1.62
5.58
3.3
2.9
—
—
—
0
0
180
1320
1.59
5.35
2.4
2.2
77.4
75.6
nmol/l
0.33
164
1184
231
1798
1.55
5.26
5.5
6.4
11.4
12.7
umol/l
0.78
222
1715
67
387
1.85
4.79
3.1
2.8
5.1
9.5
umol/l
2.05
60
343
71
419
1.82
4.74
2.5
2.2
2.3
2.3
g/l
0.05
66
392
348
3005
1.59
4.74
19.1
15.4
13.8
13.6
%
1.03
342
2933
150
1082
1.56
4.67
3.0
2.4
73.5
56.9
u/l
0.38
142
1003
287
2390
1.51
4.48
3.3
3.0
56.6
48.9
u/l
0.50
273
2242
148
1082
1.53
4.29
2.7
3.5
2.3
2.4
mmol/l
1.43
130
956
66
395
1.78
4.20
24.4
19.8
1.7
1.3
inr
1.37
13
61
114
791
1.58
4.15
2.2
1.9
3.0
2.9
mg/l
0.17
98
658
44
234
1.97
4.03
3.0
3.1
67.9
64.1
ml/min/173m2
0.19
14
96
244
2000
1.45
3.91
5.4
4.5
6.8
6.8
mmol/l
0.19
227
1866
184
1430
1.47
3.89
2.9
2.4
98.8
140.5
ug/l
2.46
170
1326
38
197
2.01
3.75
1.8
1.7
—
—
—
0
0
14
45
3.18
3.68
1.0
1.1
2.8
3.6
u/ml
—
8
19
310
2676
1.46
3.67
4.1
3.7
14.6
14.7
pmol/l
0.45
282
2429
139
1037
1.48
3.56
4.0
3.9
13.2
8.4
mg/mmol
0.30
96
670
68
431
1.67
3.54
1.8
1.8
1.5
1.5
%
0.19
58
378
15
52
2.95
3.49
1.1
1.1
0.4
3.8
u/ml
—
7
15
6
7
8.66
3.27
1.5
1.0
53.2
78.7
%
—
6
7
17
66
2.63
3.25
1.8
1.5
—
—
—
0
0
102
728
1.51
3.22
1.3
1.2
1.9
1.7
u/ml
0.06
22
192
60
381
1.66
3.11
1.8
1.9
—
—
—
0
0
416
3867
1.61
2.97
18.8
14.6
78.5
77.6
umol/l
0.13
416
3867
360
3249
1.45
2.97
5.0
4.4
1.9
2.3
mu/l
0.57
339
2958
22
102
2.21
2.91
1.3
1.7
11.0
10.8
g/l
0.08
17
88
104
761
1.47
2.89
2.6
2.3
—
—
—
0
0
49
301
1.70
2.88
2.4
2.6
7.7
8.4
ug/l
0.12
41
263
59
381
1.63
2.87
1.7
1.9
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
20
91
2.25
2.77
2.6
2.4
0.2
0.4
u/ml
2.40
14
55
77
535
1.52
2.75
1.8
1.9
—
—
—
0
0
20
92
2.23
2.71
1.2
1.7
98.2
88.6
%
2.24
20
83
121
925
1.41
2.65
1.6
1.6
1.3
1.4
mmol/l
0.66
108
770
7
15
4.72
2.60
1.1
4.5
1137.7
641.9
u/ml
—
7
15
48
302
1.66
2.60
6.3
6.9
1.3
1.4
mmol/l
0.24
48
290
163
1317
1.36
2.55
4.1
3.5
25.8
70.6
ng/l
0.96
106
892
122
940
1.40
2.55
3.5
3.0
912.6
1281.5
ng/l
1.44
105
792
365
3342
1.40
2.45
6.3
5.4
41.0
40.1
mmol/mol
0.89
348
3083
9
28
3.26
2.32
1.1
1.0
—
—
—
0
0
46
297
1.61
2.27
2.3
2.2
0.2
0.2
g/l
0.15
39
280
197
1661
1.32
2.26
3.9
3.3
0.0
0.0
estimate
0.50
22
276
98
742
1.40
2.25
4.5
3.5
1.0
1.0
kg/l
0.07
14
97
39
242
1.67
2.24
4.8
3.5
114.8
82.4
ng/l
0.55
32
215
22
114
1.97
2.24
1.3
1.7
4.1
3.7
g/l
0.79
15
81
22
114
1.97
2.24
1.3
1.7
7.8
7.0
g/l
0.59
15
85
22
114
1.97
2.24
1.3
1.7
—
—
—
0
0
380
3520
1.40
2.24
4.5
4.2
6.1
6.0
mmol/l
1.07
364
3206
16
73
2.23
2.23
1.2
1.4
—
—
—
0
0
16
73
2.23
2.23
1.2
1.4
—
—
—
0
0
194
1642
1.31
2.13
3.9
3.3
0.0
0.0
estimate
0.00
22
286
12
49
2.49
2.12
1.2
1.2
—
1.1
—
0
5
97
744
1.38
2.06
1.7
1.5
24.0
20.4
nmol/l
1.10
88
628
252
2217
1.29
2.04
3.1
2.9
—
—
—
0
0
56
391
1.49
1.98
6.5
7.7
1.1
1.4
mmol/l
0.28
47
298
11
45
2.48
1.94
1.0
1.1
—
—
—
0
0
17
85
2.04
1.92
1.2
2.0
178.4
185.4
%
0.13
17
80
13
58
2.28
1.92
1.6
1.7
—
—
—
0
0
193
1651
1.28
1.91
5.5
4.5
0.0
0.0
estimate
0.00
24
290
20
107
1.91
1.89
1.4
1.7
3.0
3.0
g/l
0.04
15
82
392
3683
1.37
1.84
5.3
4.7
2.8
2.8
mmol/l
0.60
370
3387
359
3330
1.32
1.84
18.6
13.5
39.6
40.1
%
0.49
266
2422
8
29
2.79
1.80
1.1
1.2
—
—
—
0
0
8
30
2.69
1.73
1.6
1.2
—
—
—
0
0
382
3590
1.33
1.67
4.4
4.2
1.4
1.5
mmol/l
0.57
365
3296
76
581
1.37
1.66
1.9
3.0
2.4
2.5
mmol/l
0.87
64
513
384
3616
1.32
1.62
4.6
4.2
4.6
4.7
mmol/l
1.20
374
3353
10
44
2.30
1.54
1.0
1.1
115.8
117.2
%
—
10
39
15
79
1.93
1.51
1.3
1.3
—
—
—
0
0
14
72
1.97
1.50
1.9
2.7
2.3
3797.4
u/l
—
5
28
44
311
1.46
1.50
5.3
3.3
1.6
1.9
mmol/l
0.25
39
238
13
66
2.00
1.44
1.3
1.3
—
37.9
—
0
6
5
16
3.15
1.44
1.0
1.1
—
—
—
0
0
30
198
1.55
1.41
2.4
3.2
4.6
4.5
pmol/l
0.34
30
180
36
248
1.49
1.40
1.2
1.5
—
—
—
0
0
30
199
1.54
1.38
1.2
1.2
143.1
151.7
u/ml
0.06
25
179
24
151
1.62
1.37
4.8
3.1
24.1
24.1
mmol/l
0.04
24
138
49
363
1.39
1.31
3.7
4.3
18.6
34.4
ug/l
0.35
36
315
71
558
1.32
1.31
2.5
3.2
0.8
0.8
mmol/l
0.39
66
523
9
43
2.11
1.31
1.2
1.2
—
—
—
0
0
364
3442
1.25
1.23
14.9
11.4
82.9
81.6
ml/min/173m2
0.57
309
2790
10
49
2.06
1.22
1.2
1.1
—
—
—
0
0
5
19
2.65
1.22
1.8
2.2
—
—
—
0
0
5
19
2.65
1.22
1.8
2.2
12.8
11.6
%
—
5
10
24
157
1.56
1.20
1.5
1.3
34.2
32.5
iu/l
0.11
24
136
23
151
1.55
1.14
2.5
2.6
40.9
39.4
u/l
0.15
18
141
8
40
2.02
1.12
1.0
1.2
—
—
—
0
0
7
31
2.28
1.10
1.0
1.0
—
—
—
0
0
32
438
0.71
1.07
4.7
4.1
34.1
31.9
%
0.53
24
299
7
33
2.14
1.06
1.3
1.0
—
—
—
0
0
5
22
2.29
1.03
1.2
1.1
—
—
—
0
0
5
22
2.29
1.03
1.6
1.2
1.5
2.0
mmol/l
—
5
22
9
47
1.93
1.02
1.3
1.1
—
—
—
0
0
14
84
1.69
0.99
1.1
1.1
—
—
—
0
0
15
92
1.65
0.98
1.2
1.2
—
—
—
0
0
9
50
1.82
0.97
1.2
1.1
—
—
—
0
0
71
583
1.26
0.97
1.6
1.7
1152.4
1170.0
nmol/l
0.07
57
443
15
93
1.63
0.95
1.2
1.2
—
—
—
0
0
21
142
1.50
0.94
3.0
3.4
12.9
19823.8
u/ml
0.59
16
127
55
440
1.28
0.93
5.7
4.7
1.1
1.0
mmol/l
1.13
50
404
6
28
2.16
0.92
1.5
1.8
—
—
—
0
0
23
160
1.46
0.90
1.3
1.2
—
—
—
0
0
362
3463
1.19
0.87
4.0
3.8
1.3
1.3
mmol/l
0.49
343
3172
16
104
1.56
0.85
1.1
1.2
—
—
—
0
0
13
80
1.64
0.85
2.0
1.8
—
—
—
0
0
27
198
1.39
0.82
1.6
1.5
—
—
—
0
0
9
55
1.65
0.74
1.2
1.2
—
—
—
0
0
5
25
2.01
0.73
1.0
1.1
—
—
—
0
0
63
531
1.21
0.70
1.5
1.4
—
—
—
0
0
7
41
1.72
0.70
1.4
1.0
—
—
—
0
0
16
111
1.46
0.66
1.1
1.1
—
1.5
—
0
12
15
103
1.47
0.65
1.5
1.5
—
—
—
0
0
7
44
1.60
0.65
2.4
2.2
13.2
13.0
%
—
7
44
5
29
1.73
0.64
2.8
2.0
—
19.2
—
0
11
5
29
1.73
0.64
1.0
1.3
1.0
1.0
g/l
—
5
29
30
379
0.78
0.64
1.5
1.8
—
—
—
0
0
12
80
1.51
0.60
1.5
1.3
—
—
—
0
0
37
303
1.24
0.56
1.4
1.9
—
—
—
0
0
10
66
1.53
0.53
1.3
1.6
—
—
—
0
0
17
127
1.35
0.50
1.9
1.7
—
—
—
0
0
7
50
1.41
0.45
2.4
2.9
6.5
8.3
u/ml
—
7
45
13
95
1.38
0.44
1.3
3.5
—
2.9
—
0
9
9
128
0.70
0.44
1.6
1.5
—
—
—
0
0
79
714
1.13
0.41
1.6
1.7
140298889.1
22278482.8
pmol/l
0.39
67
597
9
66
1.37
0.38
2.0
3.6
14.1
114.2
u/ml
—
9
61
21
170
1.25
0.38
4.1
2.4
0.6
0.7
%
0.22
21
164
22
180
1.23
0.36
2.6
2.8
55.5
39.8
u/ml
0.17
22
174
6
44
1.37
0.34
1.7
1.8
—
—
—
0
0
6
46
1.31
0.33
1.7
1.8
—
—
—
0
0
7
100
0.70
0.31
1.3
1.6
—
—
—
0
0
16
129
1.25
0.30
2.2
1.9
—
—
—
0
0
15
122
1.24
0.27
2.2
1.8
—
—
—
0
0
12
95
1.27
0.26
1.4
1.6
—
—
—
0
0
30
263
1.15
0.26
1.4
1.9
—
—
—
0
0
140
1333
1.07
0.26
4.2
3.4
—
—
—
0
0
22
190
1.17
0.23
2.5
2.5
1.3
0.2
e6/l
0.48
22
184
5
40
1.25
0.22
3.6
2.3
—
—
—
0
0
23
262
0.87
0.21
2.7
3.2
1.2
1.2
mmol/l
0.43
23
224
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
2.5
—
0
5
5
43
1.16
0.21
1.4
1.4
381.0
324.0
pmol/l
—
5
35
128
1225
1.06
0.21
4.1
4.6
1.6
3.6
ug/l
1.87
112
1090
6
51
1.18
0.19
1.7
1.7
—
—
—
0
0
21
184
1.15
0.19
1.0
1.0
—
—
—
0
0
35
319
1.10
0.18
2.5
2.9
—
—
—
0
0
105
1006
1.06
0.17
3.9
4.0
22.5
22.3
%
0.07
41
476
8
68
1.18
0.16
1.4
1.6
—
—
—
0
0
55
517
1.07
0.15
1.5
1.4
—
—
—
0
0
13
112
1.17
0.14
3.2
3.1
—
—
—
0
0
18
161
1.12
0.13
1.6
1.7
—
—
—
0
0
43
409
1.06
0.09
11.6
6.9
—
—
—
0
0
5
48
1.04
0.09
1.4
1.8
—
—
—
0
0
22
237
0.92
0.09
1.1
1.2
154.8
165.7
iu/ml
—
9
99
7
66
1.06
0.08
1.6
1.5
—
—
—
0
0
8
77
1.04
0.07
1.5
1.8
—
—
—
0
0
8
90
0.89
0.07
1.1
1.3
—
—
—
0
0
74
721
1.03
0.06
2.5
2.9
0.6
0.8
ug/l
1.90
42
445
12
131
0.91
0.05
1.6
1.7
—
—
—
0
0
22
209
1.06
0.04
3.2
3.3
1.6
1.9
mmol/l
0.20
17
162
89
892
1.00
0.00
4.3
3.4
0.0
0.0
estimate
0.50
21
283
0
7
0.00
0.00
0.0
1.1
—
88.3
—
0
7
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
7.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
29.8
—
0
7
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
8
82
0.98
0.00
1.5
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
8
84
0.95
0.00
1.3
1.4
—
—
—
0
0
5
53
0.94
0.00
1.0
1.1
—
11.2
—
0
13
5
49
1.02
0.00
1.2
1.3
0.1
0.5
nmol/l
—
5
42
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
112.5
—
0
5
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_CONTRACTUREJOINT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_CONTRACTUREJOINT | 1.246 [1.0, 1.56] | 0.055 |
| Birth year | 0.997 [0.99, 1.01] | 0.451 |
During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 1054 females with M13_CONTRACTUREJOINT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_CONTRACTUREJOINT | 1.31 [1.07, 1.6] | 0.009 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 187 out of 1179 males with M13_CONTRACTUREJOINT died.
Mortality risk
Mortality risk for people of age
years, who have M13_CONTRACTUREJOINT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.124% | 0.248% |
| 5 | 0.842% | 1.646% |
| 10 | 1.817% | 4.002% |
| 15 | 3.492% | 7.282% |
| 20 | 6.293% | 11.894% |
Relationships between endpoints
↥Index endpoint: M13_CONTRACTUREJOINT – Contracture of joint
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data