No definition available.
Isolated proteinuria with specified morphological lesion
DOID EFO Endpoint Browser PheWeb
N14_ISOLPROTEINURIA
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
395 |
4. Check minimum number of eventsNone |
395 |
5. Include endpointsNone |
395 |
6. Filter based on genotype QC (FinnGen only) |
395 |
Control definitions (FinnGen only)
- Control exclude
- N14_GLOMERULAR
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- N00-N08
- Name in latin
- Proteinuria isolata cum laesione morphologica specificata
Similar endpoints
↥List of similar endpoints to
Isolated proteinuria with specified morphological lesion
based on the number of shared cases.
Similar with more cases:
- Glomerulonephritis
- Glomerular diseases
- Genitourinary diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2409 | 1167 | 1221 |
| Only index persons | 2118 | 1030 | 1088 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 57.83 | 56.49 | 59.16 |
| Only index persons | 55.61 | 53.58 | 57.53 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 395 | 193 | 202 |
| Unadjusted period prevalence (%) | 0.08 | 0.07 | 0.09 |
| Median age at first event (years) | 55.99 | 50.34 | 61.39 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 358
- Matched controls
- 3578
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N06.9
ICD-10 Finland
Isolated proteinuria with specified morphological lesion, unspecified
+∞
217.6
186
*
N06.0
ICD-10 Finland
Isolated proteinuria with specified morphological lesion, minor glomerular abnormality
+∞
76.9
71
*
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
309.6
75.5
74
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
58.9
64.5
75
16
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
17.9
64.4
105
81
R80
ICD-10 Finland
Isolated proteinuria
134.3
63.3
66
6
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
43.8
52.9
65
18
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
129.5
52.4
55
5
N18.8
ICD-10 Finland
Other chronic renal failure
26.6
52.3
73
34
A11CC03
ATC
alfacalcidol; systemic
39.1
49.3
62
19
L04AA06
ATC
mycophenolic acid; systemic
53.9
46.6
55
12
C03CA01
ATC
furosemide; systemic
5.3
45.5
190
629
N04.9
ICD-10 Finland
Nephrotic syndrome, unspecified
+∞
44.7
42
*
Z94.0
ICD-10 Finland
Kidney transplant status
107.9
44.0
47
5
127
Kela drug reimbursment
Transplant complication
59.8
40.6
47
9
N06.1
ICD-10 Finland
Isolated proteinuria with specified morphological lesion, focal and segmental glomerular lesions
+∞
40.4
38
*
A12AA04
ATC
calcium carbonate; oral
38.5
39.7
50
15
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
118.5
39.7
42
*
N39.1
ICD-10 Finland
Persistent proteinuria, unspecified
205.6
36.5
37
*
TK800
NOMESCO Finland
Hemodialysis
34.9
35.8
46
15
Z49.0
ICD-10 Finland
Preparatory care for dialysis
87.4
35.6
39
5
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
72.6
34.8
39
6
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
99.8
33.4
36
*
L04AD01
ATC
ciclosporin; systemic
32.4
32.9
43
15
N04.1
ICD-10 Finland
Nephrotic syndrome, focal and segmental glomerular lesions
+∞
32.8
31
*
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
+∞
32.8
31
*
137
Kela drug reimbursment
Uraemia requiring dialysis
79.6
32.5
36
5
Z49.1
ICD-10 Finland
Extracorporeal dialysis
58.7
32.0
37
7
L04AA01
ATC
[U] ciclosporin; systemic
32.9
31.5
41
14
C08CA01
ATC
amlodipine; oral
3.8
31.0
197
868
N18.0
ICD-10 Finland
End-stage renal disease
74.8
30.5
34
5
205
Kela drug reimbursment
Chronic hypertension
3.9
30.3
167
651
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.4
29.9
102
247
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
+∞
29.6
28
*
N04.0
ICD-10 Finland
Nephrotic syndrome, minor glomerular abnormality
+∞
29.6
28
*
B03XA02
ATC
darbepoetin alfa; parenteral
32.5
29.2
38
13
C09AA02
ATC
enalapril; systemic
4.4
28.9
127
399
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
+∞
28.5
27
*
B05DA
ATC
Isotonic solutions
84.7
28.2
31
*
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
58.3
27.7
32
6
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.6
26.9
166
692
N06.2
ICD-10 Finland
Isolated proteinuria with specified morphological lesion, diffuse membranous glomerulonephritis
+∞
26.4
25
*
N06.8
ICD-10 Finland
Isolated proteinuria with specified morphological lesion, other
+∞
26.4
25
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
22.2
26.3
38
19
V03AE01
ATC
polystyrene sulfonate; oral
36.2
26.0
33
10
Z49.2
ICD-10 Finland
Other dialysis
101.0
26.0
28
*
B05DB
ATC
Hypertonic solutions
145.5
26.0
27
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
267.9
25.0
25
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
7.4
23.8
59
93
M04AA01
ATC
allopurinol; systemic
4.4
22.2
90
254
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
4.5
21.1
81
216
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
116.8
20.8
22
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
7.7
20.6
49
72
N03.1
ICD-10 Finland
Chronic nephritic syndrome, focal and segmental glomerular lesions
+∞
20.0
19
*
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
111.2
19.8
21
*
N06.3
ICD-10 Finland
Isolated proteinuria with specified morphological lesion, diffuse mesangial proliferative glomerulonephritis
+∞
18.9
18
*
N19
ICD-10 Finland
Unspecified kidney failure
10.4
18.4
36
38
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
6.2
18.2
51
94
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
18.0
195
1096
N03.2
ICD-10 Finland
Chronic nephritic syndrome, diffuse membranous glomerulonephritis
+∞
17.9
17
*
N04.2
ICD-10 Finland
Nephrotic syndrome, diffuse membranous glomerulonephritis
+∞
17.9
17
*
N03.8
ICD-10 Finland
Chronic nephritic syndrome, other
+∞
17.9
17
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
188.9
17.7
18
*
N03.0
ICD-10 Finland
Chronic nephritic syndrome, minor glomerular abnormality
+∞
16.8
16
*
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
94.5
16.7
18
*
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
94.5
16.7
18
*
H02AB04
ATC
methylprednisolone; systemic
3.4
16.6
90
319
C10AA05
ATC
atorvastatin; oral
2.6
16.3
170
917
P01BA02
ATC
hydroxychloroquine; oral
4.5
16.2
60
152
B03XA01
ATC
erythropoietin; parenteral
49.9
16.2
19
*
C08CA13
ATC
lercanidipine; oral
3.6
15.9
78
255
N17.9
ICD-10 Finland
Acute renal failure, unspecified
9.6
15.8
32
36
WW200
NOMESCO Finland
Immunization
10.2
15.8
31
33
C08CA02
ATC
felodipine; oral
4.2
15.7
63
172
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
+∞
15.7
15
*
I10
ICD-10 Finland
Essential (primary) hypertension
2.5
15.7
237
1557
V03AE02
ATC
sevelamer; oral
89.0
15.7
17
*
TK820
NOMESCO Finland
Peritoneal dialysis
89.0
15.7
17
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
5.8
15.5
45
87
C02AC05
ATC
moxonidine; oral
6.1
14.9
41
74
N03.3
ICD-10 Finland
Chronic nephritic syndrome, diffuse mesangial proliferative glomerulonephritis
+∞
14.7
14
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.3
14.6
56
147
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
8.6
14.4
31
39
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
5.5
13.4
40
80
C09CA01
ATC
losartan; oral
2.6
13.2
117
561
H02AB06
ATC
prednisolone; systemic
2.3
13.0
193
1208
C10AA01
ATC
simvastatin; oral
2.3
12.7
180
1095
RD210
NOMESCO Finland
NA
11.6
12.7
23
21
ZX120
NOMESCO Finland
Intravenous
3.9
12.7
55
161
K65.0
ICD-10 Finland
Acute peritonitis
18.1
12.6
19
11
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
5.8
12.6
36
68
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
+∞
12.6
12
*
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
7.0
12.3
30
46
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
39.0
12.3
15
*
H05BX01
ATC
cinacalcet; oral
39.0
12.3
15
*
WZB00
NOMESCO Finland
Telephone receipt or other advice
2.4
12.2
126
653
M10.9
ICD-10 Finland
Gout, unspecified
4.6
12.1
43
104
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.0
12.1
50
140
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
5.8
12.0
34
64
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.0
11.9
77
303
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.4
11.8
43
107
V03AE03
ATC
lanthanum carbonate; oral
67.2
11.7
13
*
L04AX01
ATC
azathioprine; systemic
5.8
11.7
33
62
N03.5
ICD-10 Finland
Chronic nephritic syndrome, diffuse mesangiocapillary glomerulonephritis
+∞
11.5
11
*
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
123.8
11.5
12
*
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
5.6
11.4
33
64
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
17.8
11.3
17
10
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
8.0
10.9
24
32
196
Kela drug reimbursment
Paricalcitol and cinacalcet
29.0
10.8
14
5
O12.1
ICD-10 Finland
Gestational proteinuria
113.2
10.5
11
*
C07AB07
ATC
bisoprolol; oral
2.1
10.2
180
1170
321
Kela drug reimbursment
Paricalcitol and cinacalcet
41.3
10.0
12
*
M01CB01
ATC
sodium aurothiomalate; parenteral
10.5
9.6
18
18
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.6
9.6
76
334
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
9.6
102
524
TPX10
NOMESCO Finland
Implantation of vascular injection port
7.9
9.6
21
28
7910X
ICD-9 Finland
Nonspecific findings on examination of urine, Proteinuria[PROTEINURIA NUD]
102.6
9.5
10
*
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
4.4
9.4
33
80
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.3
9.3
95
481
I12.0
ICD-10 Finland
Hypertensive renal disease with renal failure
14.2
9.3
15
11
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
3.2
9.2
51
179
WX202
NOMESCO Finland
Supraclavicular plexus blockade
9.4
9.1
18
20
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
37.7
9.1
11
*
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
3.2
9.0
48
165
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
24.7
9.0
12
5
A07EC01
ATC
sulfasalazine; oral, rectal
3.3
8.8
44
145
TJA33
NOMESCO Finland
Percutaneous introduction of peritoneal dialysis catheter
51.3
8.7
10
*
J01FF01
ATC
clindamycin; systemic
2.2
8.7
109
601
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
8.7
111
620
J01MA02
ATC
ciprofloxacin; systemic
2.0
8.6
152
966
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
28.3
8.5
11
*
L04AA13
ATC
leflunomide; oral
5.5
8.5
24
46
N06.4
ICD-10 Finland
Isolated proteinuria with specified morphological lesion, diffuse endocapillary proliferative glomerulonephritis
+∞
8.4
8
*
58209
ICD-8 Finland
Chronic nephritis, Unspecified
+∞
8.4
8
*
N05.9
ICD-10 Finland
Unspecified nephritic syndrome, unspecified
+∞
8.4
8
*
D89.80
ICD-10 Finland
Immunoglobulin A (IgA) deposits in organisms
+∞
8.4
8
*
N06.5
ICD-10 Finland
Isolated proteinuria with specified morphological lesion, diffuse mesangiocapillary glomerulonephritis
+∞
8.4
8
*
N04.5
ICD-10 Finland
Nephrotic syndrome, diffuse mesangiocapillary glomerulonephritis
+∞
8.4
8
*
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.0
8.3
49
181
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
2.3
8.0
81
404
C02CA01
ATC
prazosin; oral
8.1
8.0
17
22
N18
ICD-10 Finland
Chronic kidney disease
13.4
7.9
13
10
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.3
7.9
40
133
U14
ICPC
Kidney symptom/complaint
9.7
7.9
15
16
WX204
NOMESCO Finland
Axillary plexus blockaced
6.2
7.8
20
34
R06.0
ICD-10 Finland
Dyspnoea
2.1
7.8
98
537
J01MA14
ATC
moxifloxacin; systemic
3.1
7.7
43
151
M06.8
ICD-10 Finland
Other specified rheumatoid arthritis
18.8
7.6
11
6
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
12.2
7.6
13
11
XW000
NOMESCO Finland
Bone marrow biopsy
5.0
7.6
23
48
306
Kela drug reimbursment
Erythropoietin and darbepoetin
81.7
7.4
8
*
M13.9
ICD-10 Finland
Arthritis, unspecified
3.4
7.4
35
111
R50.9
ICD-10 Finland
Fever, unspecified
2.5
7.4
61
274
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
7.4
83
435
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.4
7.3
35
112
N04.3
ICD-10 Finland
Nephrotic syndrome, diffuse mesangial proliferative glomerulonephritis
+∞
7.3
7
*
N00.0
ICD-10 Finland
Acute nephritic syndrome, Minor glomerular abnormality
+∞
7.3
7
*
U88
ICPC
Glomerulonephritis/nephrosis
+∞
7.3
7
*
N05.8
ICD-10 Finland
Unspecified nephritic syndrome, other
+∞
7.3
7
*
N06
ICD-10 Finland
Isolated proteinuria with specified morphological lesion
+∞
7.3
7
*
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
5.0
7.3
22
46
WW500
NOMESCO Finland
Blood transfusion
4.4
7.3
25
60
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.3
7.3
72
355
C09CA06
ATC
candesartan; oral
2.2
7.2
84
445
M10.3
ICD-10 Finland
Gout due to impairment of renal function
30.7
7.2
9
*
RS221
NOMESCO Finland
NA
8.2
7.2
15
19
R4110
NOMESCO Finland
Physiotherapy
2.0
7.2
99
563
E66.8
ICD-10 Finland
Other obesity
4.0
7.1
27
71
XPX08
NOMESCO Finland
Intraoperative flow measurement
12.4
7.1
12
10
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.3
7.0
72
359
J01MA12
ATC
levofloxacin; systemic
2.2
6.9
78
407
C07AG02
ATC
carvedilol; oral
3.6
6.9
30
89
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
6.3
6.9
17
28
212
Kela drug reimbursment
Gout
7.4
6.8
15
21
H26.3
ICD-10 Finland
Drug-induced cataract
23.0
6.7
9
*
SPAT1262
SPAT
Handing over of treatment supplies
2.2
6.7
76
398
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
5.0
6.6
20
42
H02AB07
ATC
prednisone; oral
2.4
6.6
61
287
C08CA03
ATC
isradipine; systemic
12.6
6.6
11
9
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.2
6.6
33
110
RF420
NOMESCO Finland
NA
10.3
6.6
12
12
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.0
6.5
37
133
C10AA03
ATC
pravastatin; oral
3.3
6.5
31
100
ZXA05
NOMESCO Finland
Left side
2.0
6.5
99
584
A12AA12
ATC
[U] calcium acetate anhydrous; systemic
71.0
6.4
7
*
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
71.0
6.4
7
*
3AC01
NOMESCO Finland
NA
14.6
6.4
10
7
KBV00
NOMESCO Finland
Insertion of stent into ureter
14.6
6.4
10
7
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
6.4
80
434
N02AX02
ATC
tramadol; systemic, rectal
1.8
6.3
156
1081
RF410
NOMESCO Finland
NA
11.3
6.3
11
10
WX002
NOMESCO Finland
Sedation and analgesia
2.1
6.3
72
377
N04.4
ICD-10 Finland
Nephrotic syndrome, diffuse endocapillary proliferative glomerulonephritis
+∞
6.3
6
*
5828A
ICD-9 Finland
Chronic glomerulonephritis, With other specified pathological lesion in kidney[GLOMERULONEPHRITIS CHRONICA ALIA DEF,EI NEFR SDR]
+∞
6.3
6
*
JN3AD
NOMESCO Finland
Abdominal CT examination
3.0
6.2
35
124
E66.00
ICD-10 Finland
Metabolic syndrome
3.2
6.2
31
104
B01AB05
ATC
enoxaparin; parenteral
1.9
6.1
112
704
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.5
6.1
46
198
M01AE01
ATC
ibuprofen; systemic, rectal
0.5
6.1
238
2807
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.7
6.1
16
29
C10AA04
ATC
fluvastatin; oral
2.8
6.0
38
146
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
246
388
15.16
172.80
18.4
4.4
1.1
1.0
mmol/l
8.13
240
357
174
221
13.28
140.02
9.1
3.2
153.0
74.1
ng/l
7.38
162
196
116
88
18.25
128.52
5.6
2.1
1.9
1.5
mg/l
2.83
110
78
99
89
14.51
98.24
3.8
4.1
45.5
27.2
mg/l
1.89
74
71
99
89
14.51
98.24
3.8
4.1
68.9
109.4
mg/l
0.24
73
71
183
410
7.45
86.24
7.1
2.1
23.3
22.8
%
0.15
170
352
187
440
7.17
83.52
6.8
2.0
2.2
2.4
g/l
4.50
181
404
260
973
5.89
65.99
10.0
2.9
6.5
7.8
mmol/l
5.43
248
809
260
977
5.86
65.54
12.4
3.7
74.3
7.5
mg/mmol
19.97
242
609
302
1348
6.27
60.24
14.8
4.4
34.2
35.8
g/l
6.43
297
1268
275
1174
5.42
56.76
10.3
3.1
—
—
—
0
0
86
142
7.46
52.31
9.3
2.7
23.3
24.3
mmol/l
1.83
79
130
232
909
4.76
52.27
8.5
3.0
0.3
0.5
e6/l
0.81
209
681
221
835
4.74
52.23
6.0
2.7
385.7
6331.2
umol/l
3.06
212
716
120
280
5.72
51.29
10.4
3.2
1.1
2.1
mmol/l
1.80
98
223
55
57
11.05
48.57
8.4
6.9
283.3
246.0
iu/ml
—
9
12
303
1546
5.12
45.95
24.8
6.3
1.2
1.2
mmol/l
0.81
270
1312
80
141
6.86
45.46
2.5
2.3
1.6
1.6
g/l
0.08
74
125
266
1250
4.45
44.65
3.9
2.2
71.0
76.2
nmol/l
2.28
260
1105
71
115
7.31
43.63
4.2
2.6
—
—
—
0
0
71
115
7.31
43.63
4.2
2.6
3.9
3.7
g/l
0.61
59
82
71
115
7.31
43.63
4.2
2.6
7.7
7.5
g/l
0.38
60
86
153
496
4.40
42.85
2.5
2.0
29.6
29.8
s
0.09
153
482
37
25
16.23
42.19
1.0
1.1
—
—
u/ml
—
0
0
85
185
5.58
38.52
7.1
3.4
0.8
1.7
mmol/l
1.49
66
140
64
106
7.01
38.35
4.5
2.7
3.0
3.2
g/l
0.77
59
82
144
491
4.04
36.86
4.6
3.2
0.8
0.8
mmol/l
0.02
138
467
86
200
5.22
36.02
7.4
3.3
5.0
5.1
kpa
0.30
86
187
277
1490
3.88
34.84
10.7
5.6
59.5
57.5
%
1.86
266
1405
49
67
8.21
34.72
5.0
2.3
8.7
8.1
kpa
1.39
49
61
55
86
7.27
34.66
4.6
3.0
0.0
0.1
g/l
0.17
55
81
54
83
7.38
34.56
4.8
2.3
23.7
24.7
mmol/l
0.77
54
73
46
59
8.69
34.34
3.3
1.2
137.9
105.3
u/ml
—
9
13
277
1512
3.79
33.56
11.2
5.9
25.3
27.5
%
2.43
268
1419
51
81
7.08
31.60
4.6
3.1
0.0
0.0
g/l
0.49
51
76
46
66
7.76
31.21
3.2
1.3
—
—
—
0
0
58
107
6.18
31.07
1.5
1.6
288.0
192.0
titre
—
5
5
40
54
8.13
28.53
1.2
1.3
—
—
—
0
0
265
1537
3.20
26.39
10.4
5.0
0.0
0.0
estimate
0.00
90
290
297
1841
3.47
26.37
14.0
9.1
4.4
4.1
e9/l
1.68
279
1614
265
1558
3.13
25.35
8.0
3.6
0.0
0.0
estimate
0.49
85
275
262
1532
3.11
25.28
8.0
3.6
0.0
0.0
estimate
0.00
88
289
85
256
3.96
25.06
7.2
2.7
41.7
66.9
ml/min/173m2
7.32
57
108
133
536
3.23
24.98
6.0
2.9
1.4
2.0
e6/l
0.72
96
294
41
66
6.82
24.96
1.7
1.2
—
—
—
0
0
136
565
3.15
24.14
5.4
2.7
0.6
1.0
e6/l
2.40
99
320
38
60
6.90
23.53
5.4
2.3
16.3
16.5
%
0.07
33
27
24
21
12.10
23.33
2.7
2.0
789.6
396.5
ml
2.93
18
11
39
64
6.65
23.29
1.8
1.2
235.2
264.4
u/ml
0.21
26
39
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
45
86
5.78
23.07
3.4
3.2
0.3
0.4
u/ml
0.64
24
48
235
1342
2.85
22.83
7.1
2.6
214.6
132.4
ug/l
3.64
228
1231
87
317
3.24
18.82
4.3
3.2
—
—
—
0
0
23
28
8.66
17.68
1.4
1.2
—
—
—
0
0
22
26
8.90
17.29
1.1
1.2
112.5
49.7
u/l
0.67
17
17
16
0
+∞
16.78
6.4
0.0
—
—
—
0
0
68
228
3.39
16.73
1.8
1.6
—
—
—
0
0
17
16
11.06
15.64
1.6
1.5
3.8
0.8
u/field
—
11
9
112
530
2.55
14.56
2.1
1.8
—
—
—
0
0
251
1691
2.33
14.38
7.6
6.3
11.4
11.2
umol/l
0.06
245
1614
293
2117
2.49
14.19
8.3
4.3
327.3
258.8
e6/l
—
7
33
25
45
5.86
13.53
1.2
1.3
—
—
—
0
0
18
7
26.83
13.48
1.0
1.0
—
—
—
0
0
141
775
2.27
12.88
3.0
2.0
3.0
3.1
mg/l
0.22
128
660
34
85
4.28
12.65
1.9
1.4
—
—
—
0
0
268
1917
2.24
12.44
10.1
4.5
6.9
6.7
mmol/l
0.93
258
1782
22
38
6.07
12.40
1.3
1.1
—
—
—
0
0
165
980
2.17
12.34
2.8
2.1
143.6
217.3
u/l
1.65
159
921
146
842
2.16
11.62
9.0
3.8
0.1
0.0
estimate
1.22
64
285
168
1036
2.08
11.11
3.6
2.4
63.6
56.7
u/l
1.80
162
970
168
1046
2.05
10.74
6.8
3.2
2.3
2.4
mmol/l
1.97
159
913
185
1198
2.02
10.56
8.6
3.8
—
—
—
0
0
79
371
2.41
10.13
2.0
1.9
—
—
—
0
0
31
86
3.83
10.03
1.5
1.8
—
—
—
0
0
31
87
3.78
9.86
3.8
2.2
407.8
81.5
ug/min
1.84
22
53
9
0
+∞
9.41
4.1
0.0
—
—
—
0
0
34
105
3.45
9.40
2.7
1.2
—
—
—
0
0
77
369
2.35
9.39
1.9
1.8
—
—
—
0
0
48
185
2.82
9.15
8.5
2.6
0.1
0.2
e6/l
0.18
48
177
301
2385
2.10
9.02
8.2
4.0
20.4
12.0
mm/h
10.40
292
2190
34
109
3.32
8.88
2.6
2.2
—
—
—
0
0
105
592
2.05
8.48
2.3
1.8
1294.3
1182.5
nmol/l
0.46
91
452
126
759
1.97
8.45
1.9
1.5
21.4
21.2
nmol/l
0.03
120
650
8
0
+∞
8.36
4.5
0.0
349.9
—
umol/l
—
8
0
183
1271
1.82
7.74
2.4
2.0
103.1
93.2
pmol/l
2.36
109
677
72
365
2.19
7.61
6.4
7.1
10.8
12.0
kpa
1.40
67
349
17
38
4.63
7.25
3.6
2.0
33.9
33.2
pg
0.47
17
38
20
52
4.00
7.07
1.3
1.5
—
—
—
0
0
12
20
6.16
6.94
1.6
1.5
27.8
5.5
u/l
—
6
8
70
366
2.11
6.81
6.5
7.2
0.6
1.2
mmol/l
0.63
55
285
28
95
3.10
6.68
1.4
1.3
—
—
—
0
0
22
64
3.58
6.66
1.3
1.7
—
—
—
0
0
26
85
3.20
6.59
1.3
1.6
—
—
—
0
0
26
85
3.20
6.59
1.4
1.6
—
—
—
0
0
204
1514
1.72
6.49
4.9
4.1
—
—
—
0
0
121
774
1.81
6.48
3.3
2.3
—
—
—
0
0
28
97
3.03
6.46
1.9
2.3
645.1
229.9
ug/l
0.52
28
91
44
194
2.43
6.40
1.4
1.4
—
—
—
0
0
16
38
4.35
6.34
1.2
1.5
—
—
—
0
0
35
139
2.67
6.31
1.8
2.3
35.6
39.1
u/l
0.48
30
126
174
1250
1.70
6.13
5.4
3.7
43.9
41.3
ng/l
0.14
145
890
12
24
5.13
5.78
1.9
2.5
0.7
3.0
u/field
—
6
7
16
41
4.02
5.77
3.0
2.1
89.7
90.4
%
0.16
16
41
126
849
1.71
5.51
1.9
1.7
1.7
1.4
mmol/l
0.72
111
702
345
3044
2.05
5.45
6.2
4.0
1.6
1.3
mmol/l
2.65
333
2795
137
948
1.68
5.41
4.3
3.1
4823.0
1134.9
ng/l
3.46
127
806
8
299
0.25
5.35
1.0
1.7
—
—
—
0
0
24
85
2.94
5.35
1.8
1.2
—
—
—
0
0
11
22
5.11
5.29
1.3
1.4
—
—
—
0
0
17
49
3.58
5.23
1.4
1.2
—
—
—
0
0
357
3212
2.16
5.00
37.6
14.0
18.4
23.5
mg/l
3.16
321
2521
335
2951
1.89
4.96
9.7
5.8
40.6
39.9
mmol/mol
0.66
325
2751
36
164
2.31
4.89
6.1
9.5
24.2
24.6
mmol/l
0.39
36
152
68
395
1.87
4.86
24.5
19.5
1.2
1.3
inr
—
10
52
149
1077
1.62
4.85
4.0
3.2
51.3
31.9
u/l
0.58
139
1029
12
29
4.24
4.66
1.2
1.2
—
—
—
0
0
349
3135
1.97
4.59
6.9
4.4
1.4
1.4
mmol/l
1.15
339
2887
26
108
2.51
4.32
3.2
2.8
—
—
—
0
0
349
3150
1.93
4.30
7.0
4.5
4.5
4.6
mmol/l
0.97
339
2920
7
6
11.84
4.29
1.0
1.2
—
—
—
0
0
19
67
2.93
4.28
1.6
1.5
—
—
—
0
0
19
67
2.93
4.28
1.6
1.5
—
—
—
0
0
10
24
4.25
3.91
1.0
1.2
—
—
—
0
0
90
603
1.64
3.87
6.2
3.5
103.4
207.7
ng/l
0.94
75
468
352
3211
1.88
3.82
7.3
5.0
2.6
2.7
mmol/l
3.61
343
2954
27
123
2.28
3.70
7.3
4.5
1.7
1.5
%
0.57
27
113
337
3046
1.72
3.63
36.6
13.0
61.9
81.5
ml/min/173m2
21.75
311
2517
37
193
2.01
3.62
2.0
1.7
—
—
—
0
0
14
46
3.12
3.56
1.1
1.8
—
—
—
0
0
14
46
3.12
3.56
4.0
3.9
4.1
1.0
%
0.54
14
40
12
36
3.41
3.50
1.3
1.2
—
—
—
0
0
275
2383
1.51
3.43
4.2
3.8
14.8
14.8
pmol/l
0.05
258
2154
95
665
1.56
3.38
1.8
1.7
465.7
437.4
pmol/l
0.37
84
549
8
14
5.81
3.35
3.0
2.4
—
—
—
0
0
99
706
1.54
3.23
1.4
1.2
2.3
1.7
u/ml
0.28
35
189
7
11
6.45
3.19
1.9
1.0
1470.3
1418.8
miu/ml
—
7
11
6
8
7.59
3.06
1.2
1.4
—
—
—
0
0
22
100
2.27
3.05
2.0
2.6
85.8
89.2
%
0.22
22
95
9
21
4.36
3.01
1.3
1.0
—
—
—
0
0
60
387
1.65
2.98
3.3
2.8
7.4
7.8
umol/l
0.13
53
342
22
102
2.23
2.92
1.9
1.5
2.1
0.0
iu/ml
—
5
21
10
30
3.39
2.92
1.3
1.4
—
—
—
0
0
363
3399
1.84
2.82
23.7
10.5
25.6
26.7
u/l
0.36
358
3284
8
19
4.27
2.69
2.0
1.8
—
—
—
0
0
8
19
4.27
2.69
2.0
1.8
—
—
—
0
0
12
43
2.85
2.67
1.2
1.8
—
—
—
0
0
12
43
2.85
2.67
1.4
1.7
—
—
—
0
0
13
49
2.71
2.65
1.5
1.6
—
—
—
0
0
7
15
4.73
2.61
1.0
2.3
1108.0
670.9
u/ml
—
7
15
9
26
3.52
2.49
5.3
2.2
—
—
—
0
0
14
57
2.51
2.47
1.4
1.6
—
—
—
0
0
10
34
2.99
2.43
1.2
1.6
—
—
—
0
0
5
8
6.31
2.38
1.0
1.0
—
—
—
0
0
7
17
4.17
2.37
1.1
1.0
—
—
—
0
0
6
13
4.67
2.28
1.0
1.0
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
5
9
5.61
2.22
1.2
4.0
156.0
100.8
%
—
5
9
315
2903
1.42
2.09
5.2
4.5
1.9
2.3
mu/l
0.50
303
2643
11
44
2.54
2.03
1.5
1.6
—
—
—
0
0
95
733
1.39
2.01
2.1
1.8
1.9
1.2
mg/l
0.56
77
569
5
11
4.59
1.94
1.8
2.6
121.6
101.0
%
—
5
11
5
11
4.59
1.94
3.0
7.3
—
—
—
0
0
12
52
2.35
1.89
2.5
2.9
3.9
4.0
mmol/l
0.46
12
52
12
52
2.35
1.89
2.5
2.9
103.2
105.7
mmol/l
0.80
12
52
23
131
1.80
1.82
2.4
1.8
—
—
—
0
0
13
60
2.21
1.79
5.6
3.5
61.0
57.9
%
0.41
13
60
8
30
2.70
1.73
1.0
1.0
—
—
—
0
0
21
120
1.79
1.65
2.3
1.7
—
—
—
0
0
5
15
3.36
1.53
1.0
1.5
—
—
—
0
0
5
15
3.36
1.53
1.0
1.9
—
—
—
0
0
5
15
3.36
1.53
1.0
1.9
—
—
—
0
0
5
15
3.36
1.53
1.0
1.9
—
—
—
0
0
15
79
1.93
1.51
1.5
1.3
—
—
—
0
0
26
399
0.63
1.51
16.0
7.3
—
—
—
0
0
12
58
2.10
1.50
5.5
3.2
4.2
4.4
e9/l
0.10
12
58
9
37
2.47
1.49
1.1
1.8
—
—
—
0
0
9
37
2.47
1.49
1.1
1.8
—
—
—
0
0
9
37
2.47
1.49
1.1
1.8
—
—
—
0
0
16
87
1.87
1.48
2.6
2.2
4091.2
4282.0
u/l
—
5
29
5
17
2.96
1.36
1.4
1.2
—
1.1
—
0
5
0
40
0.00
1.33
0.0
1.5
—
—
—
0
0
14
76
1.87
1.31
1.3
1.3
—
—
—
0
0
5
18
2.80
1.29
1.0
1.8
—
—
—
0
0
5
18
2.80
1.29
1.0
1.8
—
—
—
0
0
5
18
2.80
1.29
1.0
1.8
—
—
—
0
0
5
18
2.80
1.29
1.0
1.8
—
—
—
0
0
8
36
2.25
1.25
4.4
3.6
—
—
—
0
0
31
438
0.68
1.23
1.5
1.4
—
—
—
0
0
5
19
2.65
1.22
2.0
1.4
—
—
—
0
0
5
19
2.65
1.22
2.0
1.4
—
—
—
0
0
17
103
1.68
1.14
1.2
1.5
—
—
—
0
0
306
2898
1.25
1.06
32.6
15.0
37.8
40.2
%
4.57
211
2126
5
23
2.19
0.98
4.8
3.6
—
—
—
0
0
13
80
1.65
0.85
1.2
1.1
—
—
—
0
0
10
58
1.74
0.80
1.1
1.1
19.0
17.5
u/l
—
10
50
6
33
1.83
0.79
1.0
1.2
—
—
—
0
0
6
33
1.83
0.79
1.0
1.1
—
—
—
0
0
5
25
2.01
0.73
4.0
1.7
—
—
—
0
0
5
26
1.93
0.71
1.4
1.9
—
—
—
0
0
5
26
1.93
0.71
1.4
2.4
12.8
13.1
%
—
5
26
5
28
1.80
0.66
1.2
1.2
—
—
—
0
0
78
679
1.19
0.64
9.1
4.0
1.0
1.0
kg/l
0.44
13
89
5
29
1.73
0.64
1.4
1.4
—
—
—
0
0
8
50
1.61
0.61
1.3
2.5
3.1
85.1
u/ml
—
8
45
8
52
1.55
0.60
2.9
1.8
—
—
—
0
0
5
86
0.58
0.57
1.4
1.4
—
—
—
0
0
15
107
1.42
0.56
1.3
1.2
—
—
—
0
0
15
107
1.42
0.56
1.3
1.2
—
—
—
0
0
10
146
0.68
0.53
3.2
1.5
—
—
—
0
0
132
1218
1.13
0.50
4.1
5.0
2.3
2.6
ug/l
0.28
120
1102
7
46
1.53
0.48
1.1
1.1
—
—
—
0
0
7
48
1.47
0.47
1.4
1.2
7.4
7.5
mmol/l
—
7
30
17
129
1.33
0.46
1.5
1.7
—
—
—
0
0
16
209
0.76
0.46
1.1
1.2
25.2
160.1
iu/ml
—
6
84
5
84
0.59
0.46
1.8
1.4
—
—
—
0
0
5
84
0.59
0.46
1.8
1.4
—
—
—
0
0
21
165
1.29
0.46
1.5
1.8
—
—
—
0
0
62
547
1.16
0.45
1.2
1.3
101.3
34.0
iu/ml
0.72
20
177
0
15
0.00
0.41
0.0
1.1
—
8.5
—
0
15
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
5
35
1.43
0.39
1.4
1.1
—
—
titre
—
0
0
5
35
1.43
0.39
1.0
1.1
—
—
—
0
0
5
35
1.43
0.39
1.0
1.1
—
—
—
0
0
5
36
1.39
0.38
1.0
1.1
—
—
—
0
0
5
36
1.39
0.38
1.0
1.1
—
—
—
0
0
5
36
1.39
0.38
1.0
1.1
—
—
—
0
0
226
2171
1.10
0.38
5.0
3.2
70.4
49.9
u/l
1.33
212
2039
25
208
1.22
0.36
1.1
1.3
—
38.6
—
0
12
6
44
1.37
0.34
1.0
1.0
—
—
—
0
0
27
228
1.20
0.34
1.9
2.4
—
18.1
—
0
10
207
1987
1.09
0.34
3.1
3.0
—
—
—
0
0
58
527
1.12
0.30
1.2
1.3
46.7
13.2
u/ml
0.54
15
203
8
63
1.28
0.28
1.5
1.3
—
—
—
0
0
8
66
1.22
0.27
1.5
1.8
—
—
—
0
0
59
542
1.10
0.26
1.5
1.5
—
—
—
0
0
43
388
1.12
0.25
2.2
1.8
1.7
1.5
%
0.84
37
342
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
63
587
1.09
0.21
2.9
2.9
2.5
2.4
mmol/l
1.61
55
524
20
173
1.16
0.21
1.3
1.3
—
—
—
0
0
11
89
1.24
0.21
1.3
1.8
136.7
230.0
pmol/l
3.05
11
82
9
111
0.81
0.20
1.7
1.8
—
—
—
0
0
6
52
1.16
0.19
1.0
1.2
—
—
—
0
0
5
45
1.11
0.10
1.2
4.6
269.2
357.1
umol/l
—
5
40
5
45
1.11
0.10
3.4
3.0
6.2
3.9
nmol/l
—
5
45
5
46
1.09
0.09
1.8
1.4
—
—
—
0
0
5
47
1.06
0.09
1.8
1.4
—
—
—
0
0
5
47
1.06
0.09
1.8
1.4
—
—
—
0
0
5
47
1.06
0.09
1.8
1.4
—
—
—
0
0
5
47
1.06
0.09
1.8
1.4
—
—
—
0
0
5
48
1.04
0.09
1.8
1.4
—
—
—
0
0
10
89
1.13
0.07
1.1
1.1
—
12.1
—
0
10
16
173
0.92
0.07
1.0
1.0
—
—
—
0
0
32
333
0.96
0.05
3.4
4.0
3.5
45.2
ug/l
1.07
23
278
97
986
0.98
0.04
3.7
4.4
28.6
21.0
%
3.80
53
468
28
291
0.96
0.04
1.9
1.8
—
—
—
0
0
312
3106
1.02
0.04
6.5
4.5
6.1
6.0
mmol/l
1.30
296
2836
73
718
1.02
0.03
3.5
3.0
1.3
0.8
ug/l
1.06
57
471
32
326
0.98
0.00
2.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
59
0.85
0.00
1.8
1.6
—
—
—
0
0
7
77
0.91
0.00
1.9
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
8
83
0.96
0.00
1.5
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
5.7
—
0
9
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
21.4
—
0
7
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
8
82
0.98
0.00
1.9
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint N14_ISOLPROTEINURIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_ISOLPROTEINURIA | 2.374 [1.89, 2.99] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.498 |
During the follow-up period (1.1.1998 — 31.12.2019), 298 out of 1035 females with N14_ISOLPROTEINURIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_ISOLPROTEINURIA | 2.47 [2.05, 2.98] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 335 out of 1068 males with N14_ISOLPROTEINURIA died.
Mortality risk
Mortality risk for people of age
years, who have N14_ISOLPROTEINURIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.206% | 0.406% |
| 5 | 1.226% | 2.37% |
| 10 | 3.842% | 6.592% |
| 15 | 7.307% | 12.895% |
| 20 | 13.146% | 21.264% |
Relationships between endpoints
↥Index endpoint: N14_ISOLPROTEINURIA – Isolated proteinuria with specified morphological lesion
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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