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Venous complications and haemorrhoids in the puerperium

EFO MESH Endpoint Browser PheWeb

O15_VENOUS_COMPLIC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — O87
  • Hospital discharge: ICD-9 — 671
  • Hospital discharge: ICD-8 — 671
  • Cause of death: ICD-10 — O87
  • Cause of death: ICD-9 — 671
  • Cause of death: ICD-8 — 671

2 out of 7 registries used, show all original rules.

396

4. Check minimum number of events

None

396

5. Include endpoints

None

396

6. Filter based on genotype QC (FinnGen only)

396

Control definitions (FinnGen only)

Control exclude
O15_COMPLIC_PUERP

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5
Parent code in ICD-10
O85-O92
Name in latin
Complicationes venosae in puerperio

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2932 2932 -
Only index persons 2824 2824 -
Unadjusted period prevalence (%)
Whole population 0.08 0.08 -
Only index persons 0.10 0.10 -
Median age at first event (years)
Whole population - 31.39 -
Only index persons - 31.32 -

-FinnGen-

Key figures

All Female Male
Number of individuals 396 396 -
Unadjusted period prevalence (%) 0.13 0.13 -
Median age at first event (years) 30.73 30.73 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
356
Matched controls
3561
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
67100
ICD-8 Finland
Puerperal phlebitis and thrombosis, Thrombophlebitis extremitatis inferioris
+∞
92.9
85
*
O87.0
ICD-10 Finland
Superficial thrombophlebitis in the puerperium
+∞
53.5
50
*
I83.9
ICD-10 Finland
Varicose veins of lower extremities without ulcer or inflammation
6.6
38.6
113
235
6712B
ICD-9 Finland
Venous complications in pregnancy and the puerperium, Superficial thrombophlebitis[THROMBOPHLEB SUPERFIC EXTR INF,PUERP AIKANA]
+∞
37.1
35
*
O87.1
ICD-10 Finland
Deep phlebothrombosis in the puerperium
+∞
28.5
27
*
B01AA03
ATC
warfarin; systemic
5.7
26.3
83
181
B01AB05
ATC
enoxaparin; parenteral
3.5
25.9
165
702
PHD99
NOMESCO Finland
Resection of other vein
6.0
25.3
75
151
O87.2
ICD-10 Finland
Haemorrhoids in the puerperium
134.0
23.9
25
*
PHD76
NOMESCO Finland
Resection of long saphenous vein
7.3
23.6
59
94
67101
ICD-8 Finland
Puerperal phlebitis and thrombosis, Thrombosis extremitatis inferioris
+∞
22.1
21
*
45499
ICD-8 Finland
Varicose veins of lower extremities, Other and unspecified, without ulcer
7.7
20.9
50
74
4549X
ICD-9 Finland
Varicose veins of lower extremities, Without mention of ulcer or inflammation
6.9
20.9
54
90
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
4.4
20.3
80
218
6718B
ICD-9 Finland
Venous complications in pregnancy and the puerperium, Other venous complications[HAEMORRHOIDES ANI,PUERP AIKANA]
+∞
20.0
19
*
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
4.3
19.6
80
225
B01AB04
ATC
dalteparin; parenteral
6.7
16.2
42
70
5611
FHL
Vena saphena Magna and / or swarm of nodule and possible local emissions
6.5
15.9
42
72
6714A
ICD-9 Finland
Venous complications in pregnancy and the puerperium, Deep phlebothrombosis, postpartum[THROMBOPHLEB PROF EXTR INFER,RASKAUDEN AIKANA]
+∞
15.7
15
*
6715A
ICD-9 Finland
Venous complications in pregnancy and the puerperium, Other phlebitis and thrombosis[PHLEBITIS/THROMBOSIS ALIA,RASKAUDEN AIKANA]
+∞
15.7
15
*
6712A
ICD-9 Finland
Venous complications in pregnancy and the puerperium, Superficial thrombophlebitis[THROMBOPHLEB SUPERFIC EXTR INF,RASKAUDEN AIKANA]
+∞
14.7
14
*
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
6.3
13.6
36
62
B01AB01
ATC
heparin; parenteral
+∞
11.5
11
*
6718A
ICD-9 Finland
Venous complications in pregnancy and the puerperium, Other venous complications[HAEMORRHOIDES ANI,RASKAUDEN AIKANA]
+∞
11.5
11
*
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
3.2
10.8
60
212
O87.3
ICD-10 Finland
Cerebral venous thrombosis in the puerperium
+∞
10.5
10
*
6714B
ICD-9 Finland
Venous complications in pregnancy and the puerperium, Deep phlebothrombosis, postpartum[THROMBOPHLEB PROF EXTR INFER,PUERP AIKANA]
+∞
10.5
10
*
4511A
ICD-9 Finland
Phlebitis and thrombophlebitis, Of deep vessels of lower extremities
24.2
10.3
14
6
6500B
ICD-9 Finland
Delivery in a completely normal case[PARTUS SINE COMPLICATIONE]
2.2
9.6
122
685
5612
FHL
Local excisions and / or perforations of relapsing varicose veins
8.7
9.2
19
23
PHM76
NOMESCO Finland
Endovenous obliteration of v.saphena magna
4.4
8.7
31
76
V230A
ICD-9 Finland
Supervision of high-risk pregnancy, Pregnancy with history of infertility
8.4
8.2
17
21
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
4.8
8.1
26
58
O87.9
ICD-10 Finland
Venous complication in the puerperium, unspecified
+∞
7.3
7
*
6715B
ICD-9 Finland
Venous complications in pregnancy and the puerperium, Other phlebitis and thrombosis[PHLEBITIS/THROMBOSIS ALIA,PUERP AIKANA]
+∞
7.3
7
*
65000
ICD-8 Finland
Delivery without mention of complication, Occipital presentation
1.9
7.1
143
939
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
2.8
6.8
46
182
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
9.6
6.8
13
14
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
2.2
6.7
72
367
67000
ICD-8 Finland
Sepsis of childbirth and the puerperium, Endometritis
+∞
6.3
6
*

Mortality – FinRegistry

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Association

Association between endpoint O15_VENOUS_COMPLIC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_VENOUS_COMPLIC.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

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Index endpoint: O15_VENOUS_COMPLIC – Venous complications and haemorrhoids in the puerperium

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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