Venous complications and haemorrhoids in the puerperium

O15_VENOUS_COMPLIC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O87
  • Hospital discharge: ICD-9 671
  • Hospital discharge: ICD-8 671
  • Cause of death: ICD-10 O87
  • Cause of death: ICD-9 671
  • Cause of death: ICD-8 671

2 out of 7 registries used, show all original rules.

396

4. Check minimum number of events

None

396

5. Include endpoints

None

396

6. Filter based on genotype QC (FinnGen only)

396

Control definitions (FinnGen only)

Control exclude
O15_COMPLIC_PUERP

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5
Parent code in ICD-10
O85-O92
Name in latin
Complicationes venosae in puerperio

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2932 2932 -
Only index persons 2824 2824 -
Unadjusted period prevalence (%)
Whole population 0.08 0.08 -
Only index persons 0.10 0.10 -
Median age at first event (years)
Whole population - 31.39 -
Only index persons - 31.32 -

-FinnGen-

Key figures

All Female Male
Number of individuals 396 396 -
Unadjusted period prevalence (%) 0.13 0.13 -
Median age at first event (years) 30.73 30.73 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
356
Matched controls
3561
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
67100
ICD-8 Finland
Puerperal phlebitis and thrombosis, Thrombophlebitis extremitatis inferioris
+∞
92.9
85
*
O87.0
ICD-10 Finland
Superficial thrombophlebitis in the puerperium
+∞
53.5
50
*
I83.9
ICD-10 Finland
Varicose veins of lower extremities without ulcer or inflammation
6.6
38.6
113
235
6712B
ICD-9 Finland
Venous complications in pregnancy and the puerperium, Superficial thrombophlebitis[THROMBOPHLEB SUPERFIC EXTR INF,PUERP AIKANA]
+∞
37.1
35
*
O87.1
ICD-10 Finland
Deep phlebothrombosis in the puerperium
+∞
28.5
27
*
B01AA03
ATC
warfarin; systemic
5.7
26.3
83
181
B01AB05
ATC
enoxaparin; parenteral
3.5
25.9
165
702
PHD99
NOMESCO Finland
Resection of other vein
6.0
25.3
75
151
O87.2
ICD-10 Finland
Haemorrhoids in the puerperium
134.0
23.9
25
*
PHD76
NOMESCO Finland
Resection of long saphenous vein
7.3
23.6
59
94
67101
ICD-8 Finland
Puerperal phlebitis and thrombosis, Thrombosis extremitatis inferioris
+∞
22.1
21
*
45499
ICD-8 Finland
Varicose veins of lower extremities, Other and unspecified, without ulcer
7.7
20.9
50
74
4549X
ICD-9 Finland
Varicose veins of lower extremities, Without mention of ulcer or inflammation
6.9
20.9
54
90
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
4.4
20.3
80
218
6718B
ICD-9 Finland
Venous complications in pregnancy and the puerperium, Other venous complications[HAEMORRHOIDES ANI,PUERP AIKANA]
+∞
20.0
19
*
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
4.3
19.6
80
225
B01AB04
ATC
dalteparin; parenteral
6.7
16.2
42
70
5611
FHL
Vena saphena Magna and / or swarm of nodule and possible local emissions
6.5
15.9
42
72
6715A
ICD-9 Finland
Venous complications in pregnancy and the puerperium, Other phlebitis and thrombosis[PHLEBITIS/THROMBOSIS ALIA,RASKAUDEN AIKANA]
+∞
15.7
15
*
6714A
ICD-9 Finland
Venous complications in pregnancy and the puerperium, Deep phlebothrombosis, postpartum[THROMBOPHLEB PROF EXTR INFER,RASKAUDEN AIKANA]
+∞
15.7
15
*
6712A
ICD-9 Finland
Venous complications in pregnancy and the puerperium, Superficial thrombophlebitis[THROMBOPHLEB SUPERFIC EXTR INF,RASKAUDEN AIKANA]
+∞
14.7
14
*
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
6.3
13.6
36
62
B01AB01
ATC
heparin; parenteral
+∞
11.5
11
*
6718A
ICD-9 Finland
Venous complications in pregnancy and the puerperium, Other venous complications[HAEMORRHOIDES ANI,RASKAUDEN AIKANA]
+∞
11.5
11
*
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
3.2
10.8
60
212
6714B
ICD-9 Finland
Venous complications in pregnancy and the puerperium, Deep phlebothrombosis, postpartum[THROMBOPHLEB PROF EXTR INFER,PUERP AIKANA]
+∞
10.5
10
*
O87.3
ICD-10 Finland
Cerebral venous thrombosis in the puerperium
+∞
10.5
10
*
4511A
ICD-9 Finland
Phlebitis and thrombophlebitis, Of deep vessels of lower extremities
24.2
10.3
14
6
6500B
ICD-9 Finland
Delivery in a completely normal case[PARTUS SINE COMPLICATIONE]
2.2
9.6
122
685
5612
FHL
Local excisions and / or perforations of relapsing varicose veins
8.7
9.2
19
23
PHM76
NOMESCO Finland
Endovenous obliteration of v.saphena magna
4.4
8.7
31
76
V230A
ICD-9 Finland
Supervision of high-risk pregnancy, Pregnancy with history of infertility
8.4
8.2
17
21
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
4.8
8.1
26
58
O87.9
ICD-10 Finland
Venous complication in the puerperium, unspecified
+∞
7.3
7
*
6715B
ICD-9 Finland
Venous complications in pregnancy and the puerperium, Other phlebitis and thrombosis[PHLEBITIS/THROMBOSIS ALIA,PUERP AIKANA]
+∞
7.3
7
*
65000
ICD-8 Finland
Delivery without mention of complication, Occipital presentation
1.9
7.1
143
939
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
2.8
6.8
46
182
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
9.6
6.8
13
14
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
2.2
6.7
72
367
67000
ICD-8 Finland
Sepsis of childbirth and the puerperium, Endometritis
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
25
53
4.97
11.34
1.2
1.2
—
—
—
0
0
133
790
2.03
9.43
2.0
1.8
2.2
0.9
mg/l
0.92
101
605
37
126
3.14
8.76
1.7
1.8
21.5
20.7
s
0.20
27
109
143
906
1.91
8.20
4.2
3.7
0.0
0.0
estimate
0.80
60
342
166
1118
1.83
7.76
11.8
6.6
1.3
1.1
inr
1.63
66
357
23
65
3.69
7.25
1.2
1.2
2.8
7.0
u/ml
—
10
23
387
3620
4.04
6.08
14.8
13.0
65.9
67.6
umol/l
1.27
387
3620
225
1739
1.68
5.95
3.8
3.4
0.0
0.0
estimate
0.80
62
329
223
1727
1.67
5.79
4.9
4.5
0.0
0.0
estimate
0.50
60
340
57
294
2.10
5.72
33.6
14.6
1.6
1.2
inr
—
5
43
222
1725
1.65
5.62
3.8
3.3
0.0
0.0
estimate
0.00
60
337
152
1082
1.66
5.37
3.1
3.1
14.0
24.1
ng/l
1.01
84
647
56
304
1.98
4.88
4.0
3.5
—
—
—
0
0
69
406
1.85
4.73
2.2
1.9
29.1
29.2
s
0.04
64
397
376
3473
2.64
4.58
13.3
12.3
3.9
3.9
mmol/l
0.72
367
3367
73
446
1.78
4.42
2.0
1.8
—
—
—
0
0
374
3460
2.46
4.29
13.3
12.2
139.9
139.8
mmol/l
0.54
365
3364
223
1813
1.53
4.11
3.7
3.9
6.3
6.4
mmol/l
0.59
209
1649
173
1340
1.52
3.96
3.7
3.1
—
—
—
0
0
45
250
1.90
3.68
4.0
3.2
—
—
—
0
0
369
3427
2.13
3.64
14.2
11.5
19.5
20.0
mg/l
0.10
300
2608
360
3326
1.91
3.44
5.6
5.1
1.7
2.2
mu/l
0.65
344
3096
13
42
3.17
3.40
1.8
2.1
—
—
—
0
0
129
975
1.48
3.19
3.7
3.0
—
—
—
0
0
117
867
1.50
3.19
3.4
3.2
—
—
—
0
0
135
1031
1.47
3.16
2.7
2.6
—
—
—
0
0
44
256
1.81
3.14
2.5
2.8
1.2
1.2
mmol/l
0.27
37
224
382
3623
2.54
3.13
13.9
10.8
—
—
—
0
0
322
2908
1.57
3.10
4.9
4.4
14.6
14.5
pmol/l
0.16
304
2703
99
721
1.50
2.91
4.4
3.6
1.0
1.0
kg/l
0.54
12
96
272
2389
1.44
2.86
4.4
4.1
—
—
—
0
0
124
949
1.45
2.82
2.3
2.0
151.9
135.6
u/l
0.28
115
897
140
1100
1.42
2.75
4.5
5.6
—
—
—
0
0
181
1503
1.38
2.52
9.2
8.1
0.0
0.0
e9/l
1.42
158
1232
194
1633
1.37
2.47
4.8
3.8
—
—
—
0
0
382
3659
2.24
2.40
10.4
9.5
23.3
24.0
u/l
0.57
372
3543
11
40
2.80
2.39
1.2
1.2
—
—
—
0
0
202
1718
1.36
2.37
5.4
5.5
0.0
0.0
e9/l
0.69
190
1504
206
1758
1.36
2.37
5.4
5.5
1.9
2.0
e9/l
0.89
193
1575
128
1018
1.38
2.28
2.5
2.3
51.5
55.6
u/l
1.00
120
941
85
631
1.44
2.24
2.4
2.3
8.0
9.1
e6/l
0.19
72
555
30
175
1.77
2.16
3.2
2.1
15186.6
4459.1
u/l
0.83
17
76
7
19
3.73
2.16
1.4
1.4
—
—
—
0
0
206
1785
1.32
2.02
5.3
5.8
0.2
0.2
e9/l
0.40
193
1594
198
1708
1.32
2.00
5.4
5.5
0.5
0.5
e9/l
0.46
186
1496
41
267
1.60
1.99
2.2
3.1
1.6
1.8
%
1.35
35
241
50
342
1.53
1.97
1.3
1.6
—
—
—
0
0
353
3334
1.54
1.94
4.4
4.2
5.7
5.8
mmol/l
0.59
330
3098
6
158
0.37
1.93
2.3
2.3
—
—
—
0
0
257
2306
1.33
1.93
3.3
3.3
—
—
—
0
0
62
447
1.46
1.90
1.9
1.7
—
—
—
0
0
14
65
2.20
1.90
4.0
3.2
3.9
4.8
e9/l
0.83
14
65
97
760
1.37
1.86
1.3
1.3
34.7
29.5
iu/ml
0.13
30
258
5
12
4.21
1.83
1.0
1.3
—
—
—
0
0
281
2566
1.33
1.79
7.2
6.8
73.4
76.8
u/l
1.13
268
2403
14
67
2.13
1.78
4.1
3.6
55.0
57.9
%
0.35
14
67
106
852
1.33
1.72
4.6
4.1
—
—
—
0
0
96
765
1.34
1.65
3.6
3.4
—
—
—
0
0
72
551
1.37
1.60
1.3
1.4
745.0
606.6
titre
0.16
16
121
81
633
1.35
1.58
2.0
1.6
—
—
—
0
0
153
1307
1.28
1.56
4.4
4.0
36.1
36.3
g/l
0.14
142
1215
5
15
3.36
1.53
1.4
1.7
137.0
142.9
nmol/l
—
5
15
220
1968
1.27
1.52
7.3
8.6
3.9
3.9
e9/l
0.01
200
1739
345
3282
1.40
1.43
3.7
3.7
1.2
1.2
mmol/l
0.71
325
3050
279
2584
1.27
1.37
4.1
4.1
11.6
11.1
mm/h
0.26
262
2408
97
796
1.29
1.34
1.8
2.3
2958.1
6536.9
umol/l
0.60
88
690
356
3414
1.42
1.31
4.1
4.1
1.6
1.6
mmol/l
0.99
337
3197
5
18
2.80
1.29
1.4
1.2
—
—
—
0
0
24
155
1.58
1.26
1.7
1.7
—
—
—
0
0
180
1599
1.23
1.25
5.6
5.5
2.6
2.8
%
0.57
169
1479
32
222
1.48
1.23
2.6
2.9
—
—
—
0
0
97
809
1.26
1.18
3.4
3.1
92.2
98.6
%
1.49
87
782
183
1637
1.22
1.16
5.7
5.6
29.3
29.7
%
0.17
176
1523
327
3112
1.29
1.14
4.9
5.1
38.5
38.7
mmol/mol
0.20
309
2911
7
30
2.36
1.13
1.1
1.0
—
—
—
0
0
8
40
2.02
1.12
1.5
1.2
—
—
—
0
0
360
3474
1.40
1.12
4.6
4.6
2.9
2.9
mmol/l
0.39
341
3247
31
219
1.45
1.11
2.6
2.8
6.2
5.9
kpa
1.02
31
214
12
66
1.84
1.10
1.0
1.4
—
—
—
0
0
5
21
2.40
1.09
1.4
1.1
—
—
—
0
0
30
212
1.45
1.07
4.1
5.9
1.3
1.3
mmol/l
0.25
30
203
172
1539
1.21
1.07
5.6
5.6
0.7
0.7
%
0.03
164
1421
31
221
1.44
1.06
2.6
2.3
—
—
—
0
0
104
885
1.24
1.06
1.2
1.3
1.3
1.7
u/ml
0.21
32
237
17
106
1.63
1.04
1.2
1.2
—
—
—
0
0
178
1603
1.20
1.02
5.9
5.8
8.0
8.1
%
0.08
172
1493
180
1623
1.20
1.02
5.3
5.5
56.8
56.0
%
0.39
174
1516
9
49
1.86
0.99
1.1
3.0
—
—
—
0
0
5
23
2.19
0.98
1.2
1.6
1.1
1.0
g/l
—
5
23
355
3431
1.33
0.97
4.2
4.1
4.8
4.9
mmol/l
0.58
333
3224
26
183
1.45
0.96
1.6
3.3
69.2
75.7
e9/l
0.54
20
134
173
1561
1.19
0.96
4.8
5.6
1.2
1.2
mmol/l
0.27
143
1304
99
847
1.23
0.96
2.7
2.6
0.1
0.5
e6/l
3.68
80
610
0
32
0.00
0.95
0.0
2.1
—
—
—
0
0
0
32
0.00
0.95
0.0
2.1
—
3.9
—
0
32
0
32
0.00
0.95
0.0
2.1
—
106.0
—
0
32
99
849
1.22
0.94
2.6
2.5
—
—
—
0
0
6
27
2.24
0.94
2.0
1.4
—
—
—
0
0
61
496
1.27
0.92
1.7
1.7
1220.2
1190.1
nmol/l
0.10
53
371
31
228
1.39
0.92
1.2
1.2
—
—
—
0
0
21
144
1.48
0.89
3.3
3.8
5.3
5.2
kpa
0.17
21
133
16
103
1.58
0.89
4.0
4.0
—
—
—
0
0
18
262
0.67
0.87
1.2
1.4
—
—
—
0
0
16
238
0.66
0.86
1.8
1.4
—
—
—
0
0
168
1524
1.18
0.86
1.9
2.0
—
—
—
0
0
16
104
1.56
0.86
2.9
3.2
0.1
0.4
g/l
—
6
30
187
1714
1.17
0.84
5.7
5.4
10.4
10.0
umol/l
0.21
177
1621
24
172
1.42
0.83
1.3
1.3
4.8
0.9
u/ml
—
5
13
27
198
1.39
0.82
4.3
7.3
8.3
7.9
mmol/l
0.10
27
189
81
692
1.21
0.80
3.3
3.5
—
—
—
0
0
21
290
0.71
0.78
1.5
1.8
—
—
—
0
0
33
254
1.33
0.76
4.3
4.0
0.2
0.1
%
—
6
54
68
574
1.22
0.76
2.6
2.3
501.8
518.1
mosm/kgh2o
0.20
57
487
5
24
2.10
0.74
1.8
2.1
6.1
6.7
mmol/l
—
5
17
8
134
0.59
0.74
1.1
1.6
—
—
—
0
0
7
38
1.86
0.74
1.4
1.3
—
—
—
0
0
31
396
0.76
0.71
1.3
1.3
—
—
—
0
0
104
921
1.18
0.70
2.7
2.8
21.6
65.0
e6/l
1.49
82
674
10
61
1.66
0.69
1.2
1.4
—
—
—
0
0
7
42
1.68
0.68
2.7
2.6
—
—
—
0
0
10
62
1.63
0.65
1.0
1.3
108.4
122.1
u/ml
—
5
14
14
95
1.49
0.65
1.1
1.1
—
110.0
—
0
8
12
79
1.54
0.63
1.4
1.3
—
—
—
0
0
18
130
1.40
0.62
1.7
1.4
1.1
1.2
g/l
0.59
18
125
8
49
1.65
0.62
3.4
2.2
—
—
—
0
0
310
3201
0.85
0.61
12.3
12.5
39.3
39.5
%
0.18
215
2433
180
1676
1.14
0.60
2.8
2.7
91.3
77.4
ug/l
0.51
172
1570
0
21
0.00
0.60
0.0
15.1
—
873.0
—
0
21
0
21
0.00
0.60
0.0
21.3
—
1734.2
—
0
21
19
140
1.38
0.59
2.9
2.8
—
—
—
0
0
13
89
1.48
0.58
1.5
1.2
3.2
3.7
mmol/l
1.22
13
82
38
460
0.81
0.58
2.3
2.2
12.3
14.0
umol/l
0.97
38
427
107
964
1.15
0.58
1.7
1.6
1.4
1.4
mmol/l
0.12
83
818
8
55
1.46
0.56
1.1
1.0
—
0.3
—
0
9
54
461
1.20
0.56
2.4
2.2
100.3
120.1
ug/g
0.30
42
360
6
37
1.63
0.56
4.2
1.6
61.0
57.0
%
—
6
37
23
294
0.77
0.55
1.3
1.4
—
—
—
0
0
17
125
1.38
0.54
2.1
1.5
—
—
—
0
0
111
1009
1.14
0.53
2.0
1.5
—
—
—
0
0
34
279
1.24
0.52
4.5
3.9
2.0
0.8
%
—
8
71
32
263
1.24
0.49
4.7
4.0
0.4
0.1
%
—
7
63
23
182
1.28
0.47
1.1
1.1
—
—
—
0
0
36
302
1.21
0.46
1.1
1.2
—
—
—
0
0
47
405
1.18
0.46
1.6
1.4
—
—
—
0
0
26
318
0.80
0.45
4.7
3.8
3.4
9.3
ug/l
1.81
21
250
15
112
1.35
0.45
2.2
1.7
7.1
4.2
iu/l
—
8
42
62
550
1.15
0.43
3.4
3.5
241.5
322.2
ng/l
0.18
44
367
16
122
1.32
0.43
2.0
1.4
—
—
—
0
0
23
185
1.26
0.43
1.3
1.9
—
—
—
0
0
47
408
1.17
0.42
1.3
1.3
—
—
—
0
0
12
87
1.39
0.42
1.3
1.1
21.6
3.2
e6/l
—
7
66
10
139
0.71
0.42
1.6
1.3
—
—
—
0
0
83
752
1.13
0.42
1.3
1.4
2.2
2.2
g/l
0.04
49
451
6
95
0.63
0.42
2.5
1.7
9.2
1.4
ug/l
—
6
88
81
733
1.13
0.42
2.1
1.8
—
—
—
0
0
5
32
1.57
0.42
1.4
1.2
—
—
—
0
0
5
32
1.57
0.42
1.0
1.0
—
—
—
0
0
22
271
0.80
0.42
1.2
1.2
—
—
—
0
0
39
334
1.19
0.41
1.3
1.2
87.4
170.4
iu/ml
1.27
13
146
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.9
—
57.0
—
0
6
114
1055
1.11
0.41
2.2
2.0
—
—
—
0
0
8
60
1.34
0.40
3.3
4.0
—
—
—
0
0
5
34
1.48
0.40
1.8
1.1
31.6
26.2
mg/l
—
5
29
121
1125
1.11
0.40
3.6
3.2
2.4
2.4
mmol/l
0.00
112
999
0
18
0.00
0.40
0.0
1.8
—
—
—
0
0
23
188
1.24
0.38
4.3
7.1
—
—
—
0
0
5
36
1.39
0.38
1.8
3.3
—
—
—
0
0
5
36
1.39
0.38
1.2
1.2
—
—
—
0
0
13
98
1.34
0.38
1.5
1.3
508.2
422.8
mg/l
0.34
13
92
105
972
1.11
0.38
3.0
3.4
7.4
7.4
ph
0.27
28
182
55
489
1.14
0.38
1.2
1.2
—
—
—
0
0
5
37
1.36
0.37
1.2
1.2
—
—
—
0
0
31
264
1.19
0.36
1.3
1.2
182.8
134.1
u/ml
0.17
26
246
6
47
1.28
0.32
1.5
1.1
—
—
—
0
0
13
101
1.30
0.32
4.8
7.0
—
—
—
0
0
140
1325
1.09
0.32
2.7
2.6
—
—
—
0
0
14
174
0.80
0.30
1.0
1.1
—
—
—
0
0
22
260
0.84
0.30
1.3
1.3
—
—
—
0
0
10
129
0.77
0.28
8.1
8.5
—
—
—
0
0
121
1144
1.08
0.28
2.9
3.3
50.8
78.1
e6/l
0.45
90
738
304
2978
1.09
0.28
14.6
14.1
13.6
13.6
%
0.06
298
2930
18
150
1.21
0.27
1.2
1.3
193.6
233.1
miu/ml
0.15
11
74
15
123
1.23
0.25
2.0
1.4
—
—
—
0
0
48
436
1.11
0.25
1.3
1.2
—
—
—
0
0
9
73
1.24
0.25
1.2
1.1
—
—
—
0
0
9
73
1.24
0.25
1.2
1.1
—
—
—
0
0
80
747
1.09
0.25
1.4
1.3
6.2
10.8
u/ml
0.71
46
303
62
572
1.10
0.25
4.3
2.5
2.4
2.4
mmol/l
0.01
54
505
12
96
1.26
0.25
5.0
5.1
—
—
—
0
0
5
39
1.29
0.23
1.0
2.2
—
—
—
0
0
29
257
1.14
0.23
4.7
3.8
2.0
0.5
%
—
5
49
47
430
1.11
0.22
2.0
2.0
—
—
—
0
0
10
79
1.27
0.22
2.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
12.1
—
101.6
—
0
5
8
101
0.79
0.21
1.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.9
—
10.0
—
0
12
0
12
0.00
0.21
0.0
2.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
44
403
1.10
0.21
1.5
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.7
—
44.8
—
0
6
6
48
1.25
0.20
1.7
2.5
6.5
7.6
mmol/l
—
6
48
6
51
1.18
0.19
1.7
2.4
1.1
1.4
mmol/l
—
6
51
33
299
1.11
0.19
3.0
3.6
—
—
—
0
0
90
855
1.07
0.19
4.8
6.7
—
—
—
0
0
6
53
1.13
0.18
1.3
1.2
—
—
—
0
0
75
709
1.07
0.18
1.5
1.4
22.4
22.4
nmol/l
0.01
67
610
13
110
1.19
0.17
3.2
3.0
24.3
24.4
mmol/l
0.02
13
102
145
1403
1.05
0.17
4.5
5.0
1.2
1.2
mmol/l
0.12
135
1275
8
68
1.18
0.16
1.4
1.2
—
—
—
0
0
17
149
1.15
0.16
4.5
5.4
—
—
—
0
0
30
274
1.10
0.15
5.7
7.2
5.3
5.2
kpa
0.24
30
267
30
274
1.10
0.15
5.6
7.2
12.9
12.7
kpa
0.09
30
267
70
665
1.06
0.15
1.6
1.6
426.1
33039314.5
pmol/l
1.06
58
566
42
391
1.08
0.15
1.3
1.3
—
—
—
0
0
9
81
1.11
0.15
1.7
1.7
—
—
—
0
0
9
83
1.09
0.14
1.7
2.3
—
—
—
0
0
12
103
1.17
0.14
1.0
1.2
—
—
—
0
0
128
1246
1.04
0.11
1.9
1.9
102.8
99.6
pmol/l
0.27
74
602
80
828
0.96
0.10
2.7
3.2
48.5
305.3
mg/l
0.98
46
482
5
46
1.09
0.09
1.0
1.1
—
—
—
0
0
12
134
0.89
0.09
1.2
1.4
—
—
—
0
0
29
273
1.07
0.08
5.3
7.2
1.5
1.5
mmol/l
0.01
22
223
5
61
0.82
0.08
2.2
2.1
—
—
—
0
0
12
133
0.90
0.08
1.2
1.4
—
—
—
0
0
12
133
0.90
0.08
1.2
1.4
—
—
—
0
0
8
78
1.03
0.07
1.8
2.6
—
—
—
0
0
9
87
1.04
0.07
1.0
1.0
—
—
—
0
0
12
132
0.91
0.06
1.2
1.4
—
—
—
0
0
89
870
1.03
0.06
3.2
3.9
11.8
6.5
mg/mmol
0.33
55
490
9
102
0.88
0.06
1.1
2.7
14.1
10.0
mg/l
—
9
95
35
365
0.95
0.06
1.4
2.1
8.7
5.3
umol/l
0.31
29
310
89
908
0.97
0.05
2.5
3.0
6.5
6.8
mmol/l
0.37
80
772
14
149
0.94
0.03
1.2
1.2
—
—
—
0
0
11
116
0.95
0.00
1.1
1.2
—
—
—
0
0
34
334
1.02
0.00
1.4
1.4
—
—
—
0
0
13
133
0.98
0.00
2.5
2.7
0.2
0.2
e6/l
0.09
13
127
12
117
1.03
0.00
3.3
2.2
1.7
1.1
%
0.74
12
117
11
106
1.04
0.00
1.2
1.4
—
—
—
0
0
12
124
0.97
0.00
1.2
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
1.6
—
0
7
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
7
71
0.99
0.00
1.6
2.5
0.6
0.8
nmol/l
—
7
58
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
5
52
0.96
0.00
1.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
5
51
0.98
0.00
1.4
1.6
—
—
—
0
0
6
60
1.00
0.00
1.0
3.0
26.3
25.6
mmol/l
—
6
52
5
56
0.89
0.00
2.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
5
55
0.91
0.00
1.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
226.9
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
56
0.89
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
8
83
0.96
0.00
1.1
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
7.2
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
7
73
0.96
0.00
6.3
5.1
3.7
3.7
mmol/l
—
7
66
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
28
280
1.00
0.00
2.6
2.1
0.2
0.2
g/l
0.11
28
268

Mortality – FinRegistry

Association

Association between endpoint O15_VENOUS_COMPLIC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_VENOUS_COMPLIC.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: O15_VENOUS_COMPLIC – Venous complications and haemorrhoids in the puerperium

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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