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This is a non-core endpoint: only basic statistics are computed.

See its core counterpart CD2_INSITU_RECTUM_EXALLC for full statistics.

Carcinoma in situ of rectum

DOID EFO Endpoint Browser

CD2_INSITU_RECTUM

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • not C3_RECTUM
516613

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D01.2&
  • Hospital discharge: ICD-9 — 2304
  • Cause of death: ICD-10 — D01.2&
  • Cause of death: ICD-9 — 2304
  • Cancer registry: Topography ICD-O-3 — C20
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 2

3 out of 7 registries used, show all original rules.

262

4. Check minimum number of events

None

262

5. Include endpoints

None

262

6. Filter based on genotype QC (FinnGen only)

262

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9
Parent code in ICD-10
D01
Name in latin
Carcinoma in situ hepatis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 262 108 154
Unadjusted period prevalence (%) 0.06 0.04 0.07
Median age at first event (years) 70.09 69.02 70.83

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
233
Matched controls
2329
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
73.0
130.2
148
54
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
46.4
120.9
157
99
8263/2-C20.9
ICD-O-3
Adenocarcinoma in situ in tubulovillous adenoma of rectum, NOS
+∞
105.4
93
*
C209, 8211, 2
ICD-O-3
NA
+∞
61.2
56
*
C209, 8148, 2
ICD-O-3
NA
+∞
53.2
49
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
36.3
49.8
64
24
WX402
NOMESCO Finland
General anaesthesia
7.7
38.9
110
243
UJF32
NOMESCO Finland
Coloscopy
6.5
38.1
141
446
D37.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Rectum
82.4
37.4
41
6
WX302
NOMESCO Finland
Thoracal epidural anesthesy
15.0
35.8
62
55
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
31.5
34.8
46
18
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
12.5
31.0
58
60
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
10.8
28.2
57
68
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
21.7
27.3
40
22
JGA73
NOMESCO Finland
Transanal excision of lesion of rectum
72.7
23.4
26
*
JFF23
NOMESCO Finland
Transversostomy
50.6
22.9
27
6
UJG02
NOMESCO Finland
Proctoscopy
23.6
21.9
31
15
B01AB05
ATC
enoxaparin; parenteral
3.7
19.3
121
529
JGB06
NOMESCO Finland
Partial proctectomy with total excision of mesorectum
48.3
18.6
22
5
JFG10
NOMESCO Finland
Closure of loop colostomy without resection
28.6
15.9
21
8
TPH07
NOMESCO Finland
Cathetrisation of artery
4.7
15.1
56
148
JGA75
NOMESCO Finland
Endoscopic microsurgical excision of lesion of rectum
+∞
14.7
14
*
C20.92
ICD-10 Finland
Malignant tumor of the rectum carcinoma of the adenoma
25.7
14.0
19
8
JGA85
NOMESCO Finland
Endoscopic mucosal or submucosal resection in rectum
57.0
14.0
16
*
WX600
NOMESCO Finland
Single shot through catheter
17.6
13.7
21
13
8140/2-C20.9
ICD-O-3
Adenocarcinoma in situ, NOS, of rectum, NOS
+∞
13.7
13
*
JGB03
NOMESCO Finland
Partial proctectomy with partial excision of mesorectum
148.3
13.6
14
*
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
5.9
13.3
38
74
C209, 8213, 2
ICD-O-3
NA
+∞
12.6
12
*
JGB04
NOMESCO Finland
Laparoscopic partial proctectomy with partial excision of mesorectum
+∞
12.6
12
*
D01.2
ICD-10 Finland
Carcinoma in situ: Rectum
+∞
12.6
12
*
JFG20
NOMESCO Finland
Closure of enterostomy with resection of exteriorised loop
137.1
12.6
13
*
JGB07
NOMESCO Finland
Laparoscopic partial proctectomy with total excision of mesorectum
137.1
12.6
13
*
K62.1
ICD-10 Finland
Rectal polyp
17.1
12.4
19
12
JG1CG
NOMESCO Finland
Extensive MRI of rectum
39.9
12.4
15
*
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
11.4
12.1
22
21
L01BC06
ATC
capecitabine; oral
7.7
11.7
27
39
R4110
NOMESCO Finland
Physiotherapy
2.8
11.4
92
437
JG1BG
NOMESCO Finland
MRI of rectum
26.6
11.3
15
6
TPH04
NOMESCO Finland
Cathetrisation of vein
3.0
11.2
76
320
B01AB10
ATC
tinzaparin; parenteral
4.7
10.0
34
81
JN4AD
NOMESCO Finland
Body CT examination
4.3
9.9
37
97
130
Kela drug reimbursment
Malignant tumour
3.9
9.3
39
114
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
6.2
9.2
24
42
Z71.8
ICD-10 Finland
Other specified counselling
2.8
9.1
69
309
TJF80
NOMESCO Finland
Ostomy education
25.2
9.0
12
5
JFF11
NOMESCO Finland
Laparoscopic loop enterostomy
93.3
8.5
9
*
TQW40
NOMESCO Finland
Remowal of suture of skin
4.4
8.3
30
76
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
6.5
8.0
20
33
WF001
NOMESCO Finland
Preoperative radiotherapy
19.1
7.7
11
6
JFG00
NOMESCO Finland
Closure of loop enterostomy without resection
82.6
7.5
8
*
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
4.2
7.1
26
68
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
5.7
6.9
19
36
D12.0
ICD-10 Finland
Benign neoplasm: Caecum
5.5
6.1
17
33
JGA05
NOMESCO Finland
Endoscopic polypectomy in rectum
13.0
6.1
10
8

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: CD2_INSITU_RECTUM – Carcinoma in situ of rectum

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).