No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
402 |
4. Check minimum number of eventsNone |
402 |
5. Include endpointsNone |
402 |
6. Filter based on genotype QC (FinnGen only) |
402 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Drug-induced osteoporosis
based on the number of shared cases.
Similar with more cases:
- Osteoporosis
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2113 | 1359 | 743 |
| Only index persons | 1899 | 1226 | 673 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.02 |
| Only index persons | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 64.57 | 67.51 | 59.16 |
| Only index persons | 63.70 | 66.76 | 58.12 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 402 | 266 | 136 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.06 |
| Median age at first event (years) | 62.77 | 63.08 | 62.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 359
- Matched controls
- 3587
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M81.4
ICD-10 Finland
Drug-induced osteoporosis
+∞
323.0
359
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
23.0
113.2
176
144
M05BA04
ATC
alendronic acid; oral
17.4
99.9
175
186
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
12.3
92.9
295
980
L04AX01
ATC
azathioprine; systemic
29.0
89.4
124
64
H02AB06
ATC
prednisolone; systemic
8.5
66.9
296
1278
M05BX04
ATC
denosumab; parenteral
14.3
52.7
94
87
M81.9
ICD-10 Finland
Osteoporosis, unspecified
15.2
51.0
88
75
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
8.4
49.2
122
208
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
7.5
48.7
132
257
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
141.4
47.1
49
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.3
46.5
259
1178
318
Kela drug reimbursment
Teriparatide
96.6
46.2
50
6
H02AB07
ATC
prednisone; oral
6.5
45.0
138
314
M05BA07
ATC
risedronic acid; oral
16.8
42.8
70
51
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
11.9
40.6
78
82
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
7.1
36.4
98
180
H05AA02
ATC
teriparatide; parenteral
74.7
35.8
40
6
P01BA02
ATC
hydroxychloroquine; oral
6.9
35.6
98
185
TPH04
NOMESCO Finland
Cathetrisation of vein
4.7
34.9
149
471
H02AB09
ATC
hydrocortisone; systemic
21.3
33.8
50
27
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
7.4
30.7
78
129
L04AA06
ATC
mycophenolic acid; systemic
28.7
30.5
41
16
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
6.9
29.8
80
143
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
15.2
28.7
48
36
ZX120
NOMESCO Finland
Intravenous
5.7
28.5
90
198
J18.9
ICD-10 Finland
Pneumonia, unspecified
4.0
28.2
144
518
J01MA12
ATC
levofloxacin; systemic
4.1
27.1
126
414
L95
ICPC
Osteoporosis
12.1
26.0
48
45
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
6.7
25.6
69
123
H02AB04
ATC
methylprednisolone; systemic
4.3
25.4
109
329
L04AA01
ATC
[U] ciclosporin; systemic
25.7
25.3
35
15
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
8.2
25.1
58
82
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.4
25.0
170
751
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.5
24.0
95
263
M05BA06
ATC
ibandronic acid; systemic
16.2
23.5
38
26
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
9.4
23.3
49
59
M05BB03
ATC
alendronic acid and colecalciferol; oral
11.0
22.3
43
44
C03CA01
ATC
furosemide; systemic
3.2
21.9
155
689
L04AD01
ATC
ciclosporin; systemic
20.5
21.7
32
17
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.5
21.5
124
472
R50.9
ICD-10 Finland
Fever, unspecified
4.1
20.8
90
269
A07EC01
ATC
sulfasalazine; oral, rectal
5.0
20.7
71
168
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
13.7
20.4
35
28
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.8
20.0
96
313
J45.0
ICD-10 Finland
Predominantly allergic asthma
5.2
19.7
65
147
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.8
19.3
92
297
K50.8
ICD-10 Finland
Other Crohn disease
17.1
19.2
30
19
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
74.0
18.9
21
*
R03AK08
ATC
formoterol and beclometasone; inhalant
8.6
18.7
41
53
A07EC02
ATC
mesalazine; oral, rectal
6.8
18.5
48
80
R03BB04
ATC
tiotropium bromide; inhalant
4.8
18.5
66
162
UJF32
NOMESCO Finland
Coloscopy
3.0
18.4
140
635
A07EA06
ATC
budesonide; oral, local oral
8.7
18.4
40
51
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
10.4
18.4
36
38
J45.1
ICD-10 Finland
Nonallergic asthma
5.3
18.3
58
125
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
55.5
18.2
21
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
7.6
18.1
43
63
R03DA04
ATC
theophylline; systemic, rectal
7.3
18.1
44
67
127
Kela drug reimbursment
Transplant complication
21.5
18.0
26
13
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
3.2
17.9
111
437
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
14.1
17.8
30
23
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.1
17.8
76
222
XG410
NOMESCO Finland
Flow-volume spirometry
7.4
17.7
43
65
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.7
17.7
63
154
K50.0
ICD-10 Finland
Crohn disease of small intestine
19.9
17.6
26
14
N02AX02
ATC
tramadol; systemic, rectal
2.6
17.3
189
1061
K50.9
ICD-10 Finland
Crohn disease, unspecified
18.6
17.2
26
15
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.4
17.1
66
175
J45.9
ICD-10 Finland
Asthma, unspecified
3.3
17.0
103
395
J01MA14
ATC
moxifloxacin; systemic
4.3
16.9
66
177
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
7.0
16.4
41
65
L04AA13
ATC
leflunomide; oral
8.4
16.3
36
47
M05BA01
ATC
etidronic acid; systemic
49.9
16.2
19
*
L01BB02
ATC
mercaptopurine; oral
49.9
16.2
19
*
J01MA02
ATC
ciprofloxacin; systemic
2.6
16.2
174
954
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
8.2
16.1
36
48
H26.3
ICD-10 Finland
Drug-induced cataract
63.0
15.9
18
*
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
4.8
15.9
55
130
ZXD05
NOMESCO Finland
Urgent procedure
2.7
15.8
143
707
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.2
15.7
63
172
M81.8
ICD-10 Finland
Other osteoporosis
23.3
15.7
22
10
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.6
15.6
77
253
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.4
15.6
60
158
L88
ICPC
Rheumatoid/seropositive arthritis
6.2
15.4
42
75
N02AA05
ATC
oxycodone; systemic
3.3
14.9
85
310
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
5.3
14.8
46
96
A02BC02
ATC
pantoprazole; systemic
2.6
14.8
265
1876
L04AB04
ATC
adalimumab; parenteral
11.6
14.8
27
25
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.1
14.7
61
172
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
8.8
14.6
31
38
D86.0
ICD-10 Finland
Sarcoidosis of lung
16.3
14.6
23
15
A07AA02
ATC
nystatin; oral
4.8
14.4
50
118
NF1AA
NOMESCO Finland
Hip X-ray examination
3.8
14.3
64
193
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.1
14.2
86
327
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
21.1
13.9
20
10
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
7.7
13.9
32
45
Z2446
NOMESCO Finland
Social worker
4.9
13.7
46
105
J01FF01
ATC
clindamycin; systemic
2.6
13.7
128
635
XF400
NOMESCO Finland
ECG with 12 standard connections
3.1
13.6
86
335
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.7
13.4
62
192
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.4
13.4
171
998
WZA10
NOMESCO Finland
Long statement of health and health related matters
15.8
13.3
21
14
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
6.6
13.3
34
56
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
7.4
13.2
31
45
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
9.0
13.0
27
32
J82
ICD-10 Finland
Pulmonary eosinophilia, not elsewhere classified
72.5
12.7
14
*
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
33.4
12.7
16
5
A01AB09
ATC
miconazole; local oral
3.6
12.5
58
180
K50.1
ICD-10 Finland
Crohn disease of large intestine
15.0
12.4
20
14
A02BC03
ATC
lansoprazole; oral
2.4
12.3
138
745
ZXE20
NOMESCO Finland
More than three and less than five hours
3.0
12.3
76
291
A02BC05
ATC
esomeprazole; systemic
2.3
12.2
178
1091
UJF30
NOMESCO Finland
Ileoscopy through colon
3.5
12.2
60
195
B01AB05
ATC
enoxaparin; parenteral
2.4
12.1
139
760
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.4
12.1
132
703
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.5
12.0
43
105
GD1AD
NOMESCO Finland
Thorax CT examination
5.2
12.0
37
77
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
6.7
12.0
30
48
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
15.4
11.9
19
13
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.7
11.9
53
159
J46
ICD-10 Finland
Status asthmaticus
7.1
11.7
28
42
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
11.7
126
664
A41.9
ICD-10 Finland
Sepsis, unspecified
6.8
11.7
29
46
Z01.8
ICD-10 Finland
Other specified special examinations
2.5
11.6
106
511
TGC00
NOMESCO Finland
Bronchial lavation
6.8
11.3
28
44
5BA08
NOMESCO Finland
NA
20.8
11.2
16
8
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.0
11.2
46
128
R03AC13
ATC
formoterol; inhalant
4.7
11.2
38
88
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
9.7
11.2
22
24
B07.9
ICD-10 Finland
Verruca simplex
6.7
11.2
28
45
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
10.5
11.2
21
21
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
7.8
11.2
25
34
R03DC03
ATC
montelukast; oral
2.8
11.1
80
336
K51.8
ICD-10 Finland
Other ulcerative colitis
11.1
10.9
20
19
R03AC12
ATC
salmeterol; inhalant
4.9
10.8
35
77
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
5.2
10.8
33
68
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.1
10.8
202
1356
WZC30
NOMESCO Finland
Teaching
2.9
10.8
71
280
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
8.9
10.7
22
26
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
14.8
10.6
17
12
K51.5
ICD-10 Finland
Left sided colitis
7.5
10.5
24
34
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
7.5
10.5
24
34
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
9.2
10.4
21
24
M01CB01
ATC
sodium aurothiomalate; parenteral
11.1
10.4
19
18
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.8
10.4
34
76
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
4.4
10.3
37
91
WX892
NOMESCO Finland
Monitored bed care
3.6
10.3
47
144
SPAT1254
SPAT
Administration of medicine
2.8
10.2
70
285
WX882
NOMESCO Finland
High dependency care
6.8
10.2
25
39
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
5.9
10.2
28
51
TPH07
NOMESCO Finland
Cathetrisation of artery
3.1
10.1
58
210
M05BX03
ATC
strontium ranelate; oral
15.2
10.1
16
11
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.1
10.1
58
211
R03BB01
ATC
ipratropium bromide; inhalant
5.1
10.0
31
65
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.0
10.0
61
231
R03BA02
ATC
budesonide; inhalant
2.5
10.0
86
399
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
17.3
10.0
15
9
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
9.1
9.9
20
23
Z94.0
ICD-10 Finland
Kidney transplant status
20.7
9.9
14
7
Z3226
NOMESCO Finland
Physiotherapist
2.5
9.9
90
430
XW000
NOMESCO Finland
Bone marrow biopsy
4.8
9.9
32
71
JN4BD
NOMESCO Finland
Extensive body CT
2.9
9.7
62
239
R06.0
ICD-10 Finland
Dyspnoea
2.3
9.7
111
593
X59
ICD-10 Finland
Exposure to unspecified factor
2.5
9.7
82
375
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.1
9.7
54
191
S97
ICPC
Chronic ulcer skin
4.5
9.7
34
82
J01DB01
ATC
cefalexin; oral
2.4
9.6
304
2495
AA1AD
NOMESCO Finland
CT of head and brain
2.3
9.4
105
551
L28
ICPC
Limited function/disability (L)
2.5
9.4
80
365
L01BB01
ATC
NA
+∞
9.4
9
*
D64.9
ICD-10 Finland
Anaemia, unspecified
3.1
9.3
52
184
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
8.1
9.3
20
26
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
9.2
150
930
R03DC01
ATC
zafirlukast; oral
8.7
9.2
19
23
M35.3
ICD-10 Finland
Polymyalgia rheumatica
4.6
9.2
31
72
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
16.1
9.1
14
9
L01AA01
ATC
cyclophosphamide; systemic
37.7
9.1
11
*
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.6
9.0
68
291
R03BA05
ATC
fluticasone; inhalant
2.4
9.0
83
397
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.3
9.0
93
470
WX002
NOMESCO Finland
Sedation and analgesia
2.3
9.0
97
501
R03AC03
ATC
terbutaline; inhalant
2.6
9.0
68
292
N03AX16
ATC
pregabalin; oral
2.2
9.0
104
555
I50.9
ICD-10 Finland
Heart failure, unspecified
2.8
9.0
61
244
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
6.6
8.9
22
35
WW200
NOMESCO Finland
Immunization
6.2
8.9
23
39
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.0
8.7
169
1116
J05AB11
ATC
valaciclovir; oral
2.7
8.7
64
271
A46
ICD-10 Finland
Erysipelas
2.6
8.7
64
272
ZXE00
NOMESCO Finland
One hour or less
2.0
8.7
158
1017
NK6PA
NOMESCO Finland
Measurement of bone density from one location with X-ray
28.3
8.5
11
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.4
8.5
77
364
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
13.2
8.4
14
11
RS221
NOMESCO Finland
NA
13.2
8.4
14
11
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.6
8.4
65
283
N03AX12
ATC
gabapentin; oral
2.4
8.4
74
344
ZX112
NOMESCO Finland
Subcutaneous
6.3
8.3
21
35
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
14.9
8.3
13
9
A02BC01
ATC
omeprazole; systemic
2.0
8.2
124
738
TDM10
NOMESCO Finland
Puncture of maxillary antrum
4.5
8.2
28
66
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.3
8.2
41
135
ZXA05
NOMESCO Finland
Left side
2.1
8.2
111
630
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
8.1
75
357
NG4AA
NOMESCO Finland
Lower leg X-ray examination
5.8
8.1
22
40
SPAT1262
SPAT
Handing over of treatment supplies
2.3
8.1
82
410
JHA00
NOMESCO Finland
Anal or perianal incision
34.2
8.1
10
*
R03AK07
ATC
formoterol and budesonide; inhalant
2.3
8.1
81
400
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.2
8.1
24
49
NH3EA
NOMESCO Finland
Feet X-ray examination with load
5.4
8.0
23
45
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.5
8.0
37
115
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.2
8.0
41
138
B01AA03
ATC
warfarin; systemic
2.3
8.0
81
406
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
8.1
8.0
17
22
Y84
ICD-10 Finland
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
13.4
7.9
13
10
J01FA06
ATC
roxithromycin; oral
1.9
7.9
162
1080
N02BE01
ATC
paracetamol; systemic, rectal
2.4
7.9
317
2718
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.0
7.8
133
826
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.5
7.8
35
106
R4190
NOMESCO Finland
Nutritional therapy
5.8
7.8
21
38
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.2
7.7
23
47
N02AJ06
ATC
codeine and paracetamol; systemic
1.9
7.7
142
905
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.3
7.7
38
124
M81.0
ICD-10 Finland
Postmenopausal osteoporosis
5.4
7.7
22
43
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
3.0
7.7
45
166
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
18.9
7.6
11
6
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
18.9
7.6
11
6
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
12.2
7.6
13
11
4930B
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA CUM EXACERBATIONE]
25.6
7.6
10
*
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.6
7.6
58
251
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.8
7.5
24
53
Z3231
NOMESCO Finland
Registered nurse
2.0
7.5
113
667
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
3.9
7.5
30
83
J45.8
ICD-10 Finland
Mixed asthma
4.9
7.5
23
49
A02BA02
ATC
ranitidine; systemic
2.2
7.5
89
477
132
Kela drug reimbursment
Sarcoidosis
13.7
7.4
12
9
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
13.7
7.4
12
9
R4110
NOMESCO Finland
Physiotherapy
2.0
7.4
109
637
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.5
7.4
33
100
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
7.3
7
*
UJD02
NOMESCO Finland
Gastroscopy
3.8
7.3
30
85
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
7.3
172
1194
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
30.7
7.2
9
*
6BA02
NOMESCO Finland
NA
30.7
7.2
9
*
SPAT1231
SPAT
Assessment of adjustments needed in living environment
8.2
7.2
15
19
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
20.5
7.2
10
5
ZXA10
NOMESCO Finland
Bilateral
2.2
7.1
81
424
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
9.1
7.1
14
16
N05CF01
ATC
zopiclone; oral
1.9
7.1
132
842
J47
ICD-10 Finland
Bronchiectasis
5.4
7.0
20
39
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.1
7.0
26
67
L99
ICPC
Musculoskeletal disease other
6.6
7.0
17
27
A01AB04
ATC
amphotericin B; local oral
3.6
7.0
30
88
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.6
7.0
51
215
UDH02
NOMESCO Finland
Rhinopharyngoscopy
3.4
7.0
33
105
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
3.8
7.0
28
78
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.4
6.9
59
270
WX722
NOMESCO Finland
PEEP
4.2
6.9
25
63
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.1
6.9
37
129
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.2
6.9
76
393
A28
ICPC
Limited function/disability NOS
2.2
6.9
70
350
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
9.6
6.8
13
14
K60.3
ICD-10 Finland
Anal fistula
9.6
6.8
13
14
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
4.9
6.8
21
45
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
4.1
6.8
25
64
C03DA01
ATC
spironolactone; oral
2.6
6.8
52
222
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.6
6.8
29
85
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.8
6.8
43
166
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
40.8
6.8
8
*
M80.8
ICD-10 Finland
Other osteoporosis with pathological fracture
40.8
6.8
8
*
X58
ICD-10 Finland
Exposure to other specified factors
2.5
6.8
55
245
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.9
6.8
124
784
H26.4
ICD-10 Finland
After-cataract
2.7
6.7
46
186
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
6.6
6.7
16
25
ZXA00
NOMESCO Finland
Right side
1.9
6.7
113
690
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
23.0
6.7
9
*
NF3AA
NOMESCO Finland
Femur X-ray examination
5.7
6.7
18
33
49300
ICD-8 Finland
Asthma, bronchiale
5.7
6.7
18
33
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.8
6.7
42
161
P01AB01
ATC
metronidazole; oral, rectal
1.8
6.7
150
1014
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.5
6.7
52
227
J01DA06
ATC
[U] cefuroxime; systemic
2.3
6.7
60
283
D86.2
ICD-10 Finland
Sarcoidosis of lung with sarcoidosis of lymph nodes
12.6
6.6
11
9
ZX108
NOMESCO Finland
Inhalation
12.6
6.6
11
9
B02.9
ICD-10 Finland
Zoster without complication
3.4
6.6
30
93
UJF92
NOMESCO Finland
Capsular endoscopy
6.4
6.5
16
26
Z50.1
ICD-10 Finland
Other physical therapy
3.2
6.5
33
111
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.9
6.5
39
147
N06AA09
ATC
amitriptyline; systemic
2.5
6.5
51
224
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.8
6.5
146
987
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.6
6.5
45
185
M32
ICD-10 Finland
Systemic lupus erythematosus
71.1
6.4
7
*
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
14.6
6.4
10
7
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
5.4
6.4
18
35
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.3
6.3
58
276
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
9.5
6.3
12
13
R11
ICD-10 Finland
Nausea and vomiting
3.0
6.3
36
130
Z2221
NOMESCO Finland
Medical doctor
1.9
6.3
107
653
NAG63
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, more than 3 vertebraea
18.4
6.3
9
5
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
7.2
6.3
14
20
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
4.6
6.3
20
45
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
27.2
6.3
8
*
L04AA17
ATC
[U] adalimumab; parenteral
27.2
6.3
8
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
6.2
148
1015
E86
ICD-10 Finland
Volume depletion
6.5
6.2
15
24
G43.9
ICD-10 Finland
Migraine, unspecified
3.9
6.2
24
65
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.0
6.2
35
125
E0000UV
ATC
NA
1.8
6.2
145
989
I50.0
ICD-10 Finland
Congestive heart failure
3.4
6.2
28
87
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
5.1
6.1
18
37
WX872
NOMESCO Finland
Intensive care
4.0
6.1
23
61
H26.2
ICD-10 Finland
Complicated cataract
6.9
6.1
14
21
DHB20
NOMESCO Finland
Polypectomy of internal nose
10.3
6.1
11
11
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
10.3
6.1
11
11
ZZH40
NOMESCO Finland
Substitute of bone
10.3
6.1
11
11
J96.1
ICD-10 Finland
Chronic respiratory failure
5.7
6.1
16
29
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.3
6.1
58
281
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.7
6.0
25
72
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.9
6.0
23
62
XF600
NOMESCO Finland
Bloodpressure measurement
3.0
6.0
32
112
Mortality – FinRegistry
↥Association
Association between endpoint DRUGADVERS_OSTEOPO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_OSTEOPO | 2.759 [2.28, 3.34] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.848 |
During the follow-up period (1.1.1998 — 31.12.2019), 395 out of 1151 females with DRUGADVERS_OSTEOPO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_OSTEOPO | 3.158 [2.41, 4.14] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 217 out of 617 males with DRUGADVERS_OSTEOPO died.
Mortality risk
Mortality risk for people of age
years, who have DRUGADVERS_OSTEOPO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.322% | 0.638% |
| 5 | 1.866% | 4.02% |
| 10 | 4.474% | 9.482% |
| 15 | 8.094% | 17.051% |
| 20 | 15.429% | 26.671% |
Relationships between endpoints
↥Index endpoint: DRUGADVERS_OSTEOPO – Drug-induced osteoporosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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