No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
455 |
4. Check minimum number of eventsNone |
455 |
5. Include endpointsNone |
455 |
6. Filter based on genotype QC (FinnGen only) |
442 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Drug-induced osteoporosis
based on the number of shared cases.
Similar with more cases:
- Osteoporosis
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2113 | 1359 | 743 |
| Only index persons | 1899 | 1226 | 673 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.02 |
| Only index persons | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 64.57 | 67.51 | 59.16 |
| Only index persons | 63.70 | 66.76 | 58.12 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 442 | 296 | 146 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.07 |
| Median age at first event (years) | 63.86 | 64.44 | 62.69 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 455
- Matched controls
- 4550
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M81.4
ICD-10 Finland
Drug-induced osteoporosis
+∞
307.7
455
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
22.1
231.7
211
171
L04AX01
ATC
azathioprine; systemic
32.3
214.3
151
69
M05BA04
ATC
alendronic acid; oral
16.6
201.2
227
258
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
13.2
127.7
380
1262
M05BX04
ATC
denosumab; parenteral
12.8
126.6
145
160
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
70.0
120.1
66
11
L01BA01
ATC
methotrexate; systemic
17.4
107.2
95
68
M81.9
ICD-10 Finland
Osteoporosis, unspecified
13.0
103.1
111
110
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
8.1
95.9
167
303
L04AA06
ATC
mycophenolic acid; systemic
29.6
93.7
64
25
L04AX03
ATC
methotrexate; systemic
8.1
90.4
152
264
H02AB09
ATC
hydrocortisone; systemic
19.8
87.7
71
42
H02AB06
ATC
prednisolone; systemic
8.9
83.7
381
1664
M05BA07
ATC
risedronic acid; oral
13.5
81.8
83
74
H02AB07
ATC
prednisone; oral
6.3
74.1
168
388
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
8.6
71.9
105
153
P01BA02
ATC
hydroxychloroquine; oral
6.6
64.1
124
243
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
7.4
62.7
105
177
318
Kela drug reimbursment
Teriparatide
96.3
60.8
66
8
ZX120
NOMESCO Finland
Intravenous
6.3
59.2
121
249
L95
ICPC
Osteoporosis
9.1
58.8
79
103
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
6.0
57.7
125
271
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.0
55.0
334
1619
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
11.7
54.6
59
57
M05BB03
ATC
alendronic acid and colecalciferol; oral
11.9
52.5
56
53
L04AD01
ATC
ciclosporin; systemic
18.2
52.0
43
26
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
7.0
51.6
88
150
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
7.9
50.9
77
115
H05AA02
ATC
teriparatide; parenteral
72.1
50.6
57
9
TPH04
NOMESCO Finland
Cathetrisation of vein
4.2
46.9
189
665
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
13.8
46.7
45
36
H02AB04
ATC
methylprednisolone; systemic
4.5
45.8
144
421
J18.9
ICD-10 Finland
Pneumonia, unspecified
4.0
44.6
200
753
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.7
42.6
120
320
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.6
39.5
223
962
L88
ICPC
Rheumatoid/seropositive arthritis
7.4
39.3
61
93
UGC12
NOMESCO Finland
Flexible bronchoscopy
5.4
37.4
83
180
L04AA13
ATC
[U] leflunomide
10.2
36.8
43
46
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
8.0
36.4
52
72
A07EC01
ATC
sulfasalazine; oral, rectal
5.1
36.1
86
198
L04AB04
ATC
adalimumab; parenteral
12.6
34.7
35
30
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.5
34.6
100
269
J01MA12
ATC
levofloxacin; systemic
3.7
34.6
149
533
K50.8
ICD-10 Finland
Other Crohn disease
13.6
34.4
33
26
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
6.7
34.2
58
97
L04AA01
ATC
[U] ciclosporin
41.8
34.0
42
11
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
10.3
33.7
39
41
J01MA14
ATC
moxifloxacin; systemic
4.7
33.7
91
232
XG410
NOMESCO Finland
Flow-volume spirometry
7.1
33.7
54
85
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
8.1
33.3
47
64
M05BA06
ATC
ibandronic acid; systemic
8.6
32.9
44
56
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.8
32.7
129
433
A07EA06
ATC
budesonide; oral, local oral
7.3
32.1
50
76
R03DA04
ATC
theophylline; systemic, rectal
5.8
31.4
62
120
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.5
31.4
140
508
R50.9
ICD-10 Finland
Fever, unspecified
3.8
31.4
119
388
J46
ICD-10 Finland
Status asthmaticus
9.0
31.3
40
48
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
8.3
30.7
42
55
R03AK08
ATC
formoterol and beclometasone; inhalant
6.5
30.2
52
88
J45.0
ICD-10 Finland
Predominantly allergic asthma
4.4
29.8
86
230
C03CA01
ATC
furosemide; systemic
3.1
29.7
205
960
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
3.3
29.5
151
594
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
8.3
29.4
40
52
J45.1
ICD-10 Finland
Nonallergic asthma
4.7
28.9
75
184
127
Kela drug reimbursment
Transplant complication
28.3
28.9
39
15
TGC00
NOMESCO Finland
Bronchial lavation
7.7
27.6
40
56
UJF32
NOMESCO Finland
Coloscopy
3.0
27.4
182
827
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
7.1
27.3
43
66
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.1
26.6
83
234
R03BB04
ATC
tiotropium bromide; inhalant
4.0
26.5
86
250
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
4.4
26.4
73
188
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
77.1
26.1
29
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.0
26.0
83
238
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
5.7
25.7
51
99
A07EC02
ATC
mesalazine; oral, rectal
5.2
25.5
57
123
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
9.7
25.0
30
33
J45.9
ICD-10 Finland
Asthma, unspecified
3.0
24.6
140
579
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.9
24.3
169
779
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
7.2
24.1
37
55
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
7.7
24.1
35
49
NF1AA
NOMESCO Finland
Hip X-ray examination
3.9
24.0
80
236
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.1
23.6
72
199
GD1AD
NOMESCO Finland
Thorax CT examination
4.8
23.4
57
132
NH3EA
NOMESCO Finland
Feet X-ray examination with load
8.8
22.5
29
35
N02AX02
ATC
tramadol; systemic, rectal
2.6
22.4
255
1489
WZC30
NOMESCO Finland
Teaching
3.1
22.4
115
446
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.6
22.2
82
259
TDM10
NOMESCO Finland
Puncture of maxillary antrum
5.8
22.1
42
78
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.8
22.0
76
229
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
6.7
21.8
36
58
A41.9
ICD-10 Finland
Sepsis, unspecified
6.4
21.6
37
62
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
35.8
21.4
27
8
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
8.1
21.0
29
38
M81.8
ICD-10 Finland
Other osteoporosis
16.8
20.9
33
21
J01MA02
ATC
ciprofloxacin; systemic
2.5
20.8
223
1253
XW000
NOMESCO Finland
Bone marrow biopsy
5.5
20.7
42
83
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.6
20.4
52
125
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.3
19.9
56
145
J96.1
ICD-10 Finland
Chronic respiratory failure
8.6
19.8
26
32
UJF30
NOMESCO Finland
Ileoscopy through colon
3.4
19.8
82
278
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
7.5
19.7
29
41
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.5
19.6
76
247
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
8.8
19.4
25
30
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
7.4
18.9
28
40
A07AA02
ATC
nystatin; oral
4.0
18.8
57
156
R03BB01
ATC
ipratropium bromide; inhalant
5.0
18.4
41
88
N02AA05
ATC
oxycodone; systemic
2.7
18.2
121
534
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.8
18.2
114
488
A02BC02
ATC
pantoprazole; systemic
2.7
17.7
353
2559
WX892
NOMESCO Finland
Monitored bed care
3.7
17.5
60
179
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.3
17.5
48
122
J01FF01
ATC
clindamycin; systemic
2.4
17.3
166
870
D86.0
ICD-10 Finland
Sarcoidosis of lung
14.0
17.2
29
22
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.3
17.0
35
70
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.8
16.9
100
414
K50.0
ICD-10 Finland
Crohn disease of small intestine
13.4
16.9
29
23
K50.9
ICD-10 Finland
Crohn disease, unspecified
13.4
16.9
29
23
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
17.1
16.7
26
16
XF400
NOMESCO Finland
ECG with 12 standard connections
2.8
16.7
104
442
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.3
16.6
45
113
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.5
16.6
63
201
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
5.0
16.2
36
77
ZXE20
NOMESCO Finland
More than three and less than five hours
2.8
16.1
92
373
WX882
NOMESCO Finland
High dependency care
6.0
16.1
29
51
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
5.2
15.9
34
70
JN4BD
NOMESCO Finland
Extensive body CT
3.1
15.9
76
279
Z2446
NOMESCO Finland
Social worker
3.7
15.9
55
165
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
23.0
15.7
22
10
R03BA02
ATC
budesonide; inhalant
2.5
15.6
119
558
R03AC13
ATC
formoterol; inhalant
3.9
15.5
49
138
WZC00
NOMESCO Finland
Treatment plan or consultation
2.2
15.5
195
1138
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
16.8
15.4
24
15
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.4
15.4
61
200
ZXD05
NOMESCO Finland
Urgent procedure
2.3
15.3
163
885
L04AD02
ATC
tacrolimus; systemic
29.8
15.3
20
7
R03DC03
ATC
montelukast; oral
2.6
15.3
109
494
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
5.4
15.3
31
61
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
15.3
137
691
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
15.1
223
1382
J47
ICD-10 Finland
Bronchiectasis
6.0
15.1
27
47
A02BC03
ATC
lansoprazole; oral
2.3
15.1
174
977
H26.3
ICD-10 Finland
Drug-induced cataract
15.8
15.0
24
16
SPAT1254
SPAT
Administration of medicine
2.8
15.0
90
374
WZA10
NOMESCO Finland
Extensive medical or dental certificate
13.8
14.9
25
19
L28
ICPC
Limited function/disability (L)
2.5
14.8
113
528
5BA08, ,
NOMESCO Finland
19.2
14.8
22
12
M05BA01
ATC
etidronic acid; systemic
21.9
14.8
21
10
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
4.1
14.8
43
114
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.5
14.8
108
495
R03DC01
ATC
zafirlukast; oral
6.6
14.7
24
38
K51.5
ICD-10 Finland
Left sided colitis
5.7
14.7
28
52
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.9
14.6
80
316
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.7
14.6
95
411
Z94.0
ICD-10 Finland
Kidney transplant status
37.4
14.5
18
5
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
11.9
14.5
26
23
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.9
14.4
44
121
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.6
14.4
28
53
A02BC01
ATC
omeprazole; systemic
2.3
14.3
160
883
M01CB01
ATC
sodium aurothiomalate; parenteral
12.5
14.2
25
21
A01AB09
ATC
miconazole; local oral
3.1
14.2
66
238
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.9
14.1
74
286
M81.0
ICD-10 Finland
Postmenopausal osteoporosis
4.8
14.0
32
70
ZXA10
NOMESCO Finland
Bilateral
2.4
13.8
119
586
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
6.0
13.8
25
44
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.5
13.7
50
155
A02BC05
ATC
esomeprazole; systemic
2.1
13.7
226
1447
WX002
NOMESCO Finland
Sedation and analgesia
2.4
13.6
121
604
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.1
13.5
220
1401
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
12.0
13.5
24
21
R03AC12
ATC
salmeterol; inhalant
3.8
13.4
43
122
M05BX03
ATC
strontium ranelate; oral
22.0
13.4
19
9
UJD02
NOMESCO Finland
Gastroscopy
4.0
13.4
40
108
TPH07
NOMESCO Finland
Cathetrisation of artery
2.8
13.4
75
300
B07.9
ICD-10 Finland
Verruca simplex
4.9
13.3
30
65
J01FA06
ATC
roxithromycin; oral
2.1
13.2
216
1373
WW200
NOMESCO Finland
Immunization
5.5
13.1
26
50
Z3226
NOMESCO Finland
Physiotherapist
2.4
13.0
114
565
R03AC03
ATC
terbutaline; inhalant
2.6
12.8
89
396
D64.9
ICD-10 Finland
Anaemia, unspecified
2.9
12.8
65
246
R03AK03
ATC
[U] fenoterol and ipratropium bromide
3.8
12.7
41
117
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.9
12.7
66
253
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.6
12.5
44
133
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.9
12.5
38
104
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
4.5
12.4
31
73
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
10.1
12.4
24
25
JN3AD
NOMESCO Finland
Abdominal CT examination
2.7
12.4
71
287
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.5
12.3
94
437
UDH02
NOMESCO Finland
Rhinopharyngoscopy
3.2
12.2
50
167
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.1
12.1
170
1013
R4190
NOMESCO Finland
Nutritional therapy
4.6
12.1
29
66
UJF92
NOMESCO Finland
Capsular endoscopy
6.1
11.9
21
36
N06AA09
ATC
amitriptyline; systemic
2.7
11.9
68
274
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.2
11.9
51
175
49300
ICD-8 Finland
Asthma, bronchiale
5.3
11.9
24
47
R06.0
ICD-10 Finland
Dyspnoea
2.1
11.8
154
891
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
5.0
11.8
26
55
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.1
11.8
53
187
L01BB02
ATC
mercaptopurine; oral
13.0
11.7
20
16
A46
ICD-10 Finland
Erysipelas
2.5
11.7
85
385
S97
ICPC
Chronic ulcer skin
3.3
11.7
47
155
K51.8
ICD-10 Finland
Other ulcerative colitis
9.0
11.7
24
28
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
11.7
139
777
J45.8
ICD-10 Finland
Mixed asthma
4.5
11.7
29
68
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.7
11.5
67
272
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.5
11.5
83
375
NF3AA
NOMESCO Finland
Femur X-ray examination
5.6
11.5
22
41
N03AX12
ATC
[U] gabapentin; oral
2.3
11.4
104
522
NK6PA
NOMESCO Finland
Measurement of bone density from one location with X-ray
36.0
11.3
14
*
J82
ICD-10 Finland
Pulmonary eosinophilia, not elsewhere classified
36.0
11.3
14
*
M35.3
ICD-10 Finland
Polymyalgia rheumatica
3.7
11.3
36
102
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
13.2
11.2
19
15
X59
ICD-10 Finland
Exposure to unspecified factor
2.2
11.2
108
554
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
4.0
11.1
32
84
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
5.9
11.1
20
35
AA1AD
NOMESCO Finland
CT of head and brain
2.1
11.1
146
845
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
5.0
11.1
24
50
A28
ICPC
Limited function/disability NOS
2.3
11.1
101
506
N05CF01
ATC
zopiclone; oral
2.0
11.0
179
1118
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.7
11.0
35
99
TPX10
NOMESCO Finland
Implantation of vascular injection port
4.8
10.8
25
55
ZX112
NOMESCO Finland
Subcutaneous
4.8
10.8
25
55
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.9
10.8
53
196
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
4.1
10.7
30
77
N03AX16
ATC
[U] pregabalin
2.1
10.7
136
776
ZXE30
NOMESCO Finland
More than five and less than seven hours
4.0
10.7
31
82
NG4AA
NOMESCO Finland
Lower leg X-ray examination
4.2
10.7
29
73
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.5
10.6
74
328
K50.1
ICD-10 Finland
Crohn disease of large intestine
9.5
10.6
21
23
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.4
10.6
82
382
R03BA05
ATC
fluticasone; inhalant
2.2
10.4
104
539
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
8.5
10.4
22
27
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
12.4
10.4
18
15
6BA02, ,
NOMESCO Finland
33.4
10.4
13
*
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
5.1
10.4
22
45
C10AC01
ATC
colestyramine; oral
4.9
10.4
23
49
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.9
10.3
258
1848
3AC01, ,
NOMESCO Finland
24.0
10.3
14
6
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
4.1
10.3
29
75
SPAT1255
SPAT
Intravenous administration of medicine
3.2
10.2
41
135
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
5.5
10.2
20
38
TK800
NOMESCO Finland
Hemodialysis
8.8
10.2
21
25
SPAT1262
SPAT
Handing over of treatment supplies
2.2
10.1
97
494
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
11.7
10.1
18
16
J01DB01
ATC
cefalexin; oral
2.4
10.1
389
3233
B01AB05
ATC
enoxaparin; parenteral
1.9
10.1
174
1102
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
41.0
10.0
12
*
I50.9
ICD-10 Finland
Heart failure, unspecified
2.4
10.0
77
358
ZXE00
NOMESCO Finland
One hour or less
1.9
9.9
195
1286
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
3.8
9.9
30
82
R03AK07
ATC
formoterol and budesonide; inhalant
2.1
9.6
110
600
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.8
9.6
51
197
132
Kela drug reimbursment
Sarcoidosis
15.5
9.6
15
10
K92.1
ICD-10 Finland
Melaena
3.4
9.5
35
109
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
3.9
9.5
28
75
L01BB01, ,
ATC
102.1
9.4
10
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
30.7
9.4
12
*
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
7.2
9.4
22
32
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
9.4
9
*
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
+∞
9.4
9
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.7
9.4
22
49
Z3231
NOMESCO Finland
Registered nurse
2.0
9.4
145
880
R4110
NOMESCO Finland
Physiotherapy
1.9
9.4
149
913
EBA15
NOMESCO Finland
Extraction of multiple teeth
4.2
9.4
25
62
J45
ICD-10 Finland
Asthma
2.5
9.4
62
268
SPAT1229
SPAT
Assessment of need for aid
2.8
9.4
49
188
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
3.5
9.4
32
95
R03BA01
ATC
beclometasone; inhalant
2.3
9.3
79
382
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.2
9.3
84
417
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.9
9.3
176
1142
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.1
9.3
39
132
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.8
9.3
29
81
G43.9
ICD-10 Finland
Migraine, unspecified
3.4
9.2
33
101
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.8
9.2
47
178
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.7
9.2
53
214
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
11.8
9.1
16
14
JN4AD
NOMESCO Finland
Body CT examination
2.5
9.1
59
252
A11CC03
ATC
alfacalcidol; systemic
7.3
9.1
21
30
S18
ICPC
Laceration/cut
1.8
9.1
229
1620
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
4.2
9.1
24
59
XG466
NOMESCO Finland
Sleep oxymetry
4.2
9.1
24
59
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
16.0
9.1
14
9
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
16.0
9.1
14
9
C03DA01
ATC
spironolactone; oral
2.3
9.1
72
338
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.1
9.0
106
583
R60.0
ICD-10 Finland
Localized oedema
2.3
9.0
73
346
N02AC04
ATC
dextropropoxyphene; oral
4.1
9.0
25
64
L01AA01
ATC
cyclophosphamide; systemic
19.1
9.0
13
7
A01AB04
ATC
amphotericin B; local oral
3.2
9.0
37
124
D86.2
ICD-10 Finland
Sarcoidosis of lung with sarcoidosis of lymph nodes
11.0
8.9
16
15
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
4.4
8.8
22
52
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
51.0
8.7
10
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
51.0
8.7
10
*
A02BA03
ATC
famotidine; systemic
3.8
8.7
27
75
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.4
8.7
61
271
L99
ICPC
Musculoskeletal disease other
4.7
8.7
20
44
H26.4
ICD-10 Finland
After-cataract
2.4
8.6
61
272
ZXA05
NOMESCO Finland
Left side
1.9
8.6
132
796
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
8.6
223
1584
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
16.7
8.6
13
8
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
10.3
8.6
16
16
E86
ICD-10 Finland
Volume depletion
6.6
8.6
21
33
J05AB11
ATC
valaciclovir; oral
2.1
8.6
88
459
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
2.8
8.6
45
173
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
3.4
8.5
31
96
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.6
8.5
53
223
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
8.1
8.4
18
23
A03
ICPC
Fever
2.2
8.4
83
426
ZX108
NOMESCO Finland
Inhalation
13.1
8.4
14
11
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.7
8.4
47
187
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.4
8.4
30
92
297, ,
Kela drug reimbursment
+∞
8.4
8
*
3028
Kela drug reimbursment
Mepolizumab
+∞
8.4
8
*
R03DX09
ATC
mepolizumab; parenteral
+∞
8.4
8
*
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
11.0
8.3
15
14
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
11.0
8.3
15
14
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.5
8.3
55
237
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
9.7
8.3
16
17
L04AB01
ATC
etanercept; parenteral
9.7
8.3
16
17
A05AA02
ATC
ursodeoxycholic acid; oral
7.3
8.3
19
27
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.6
8.3
49
200
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
3.8
8.3
25
68
ZZA00
NOMESCO Finland
Split skin graft
4.4
8.3
21
50
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
3.5
8.2
29
88
H26.2
ICD-10 Finland
Complicated cataract
8.4
8.2
17
21
Y84
ICD-10 Finland
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
12.0
8.1
14
12
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.8
8.1
43
166
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.2
8.1
72
354
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
34.0
8.1
10
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
8.1
183
1242
A02BA02
ATC
ranitidine; systemic
2.0
8.1
107
612
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.9
8.1
39
143
EBA10
NOMESCO Finland
Operative extraction of tooth
2.4
8.1
60
273
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.2
8.1
33
110
WVA30, ,
SPAT
3.2
8.1
33
110
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.9
8.1
145
918
R03BA08
ATC
ciclesonide; inhalant
2.5
8.0
52
222
B01AB04
ATC
dalteparin; parenteral
3.2
8.0
32
105
A03CA02
ATC
clidinium and psycholeptics; oral
2.9
8.0
38
138
R03AK11
ATC
formoterol and fluticasone; inhalant
4.1
8.0
22
56
B01AA03
ATC
warfarin; systemic
2.0
7.9
93
509
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
3.1
7.8
33
112
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.6
7.8
26
76
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
4.5
7.8
19
44
R11
ICD-10 Finland
Nausea and vomiting
2.5
7.7
50
214
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.2
7.7
67
327
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
18.7
7.6
11
6
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
3.9
7.6
22
58
Z94.4
ICD-10 Finland
Liver transplant status
25.5
7.6
10
*
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
3.1
7.5
31
104
ZXE40
NOMESCO Finland
More than seven and less than nine hours
4.5
7.5
18
41
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.2
7.5
30
99
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
7.9
7.4
16
21
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
81.4
7.4
8
*
M32
ICD-10 Finland
Systemic lupus erythematosus
81.4
7.4
8
*
NDG30
NOMESCO Finland
Fusion of wrist, total
13.7
7.4
12
9
R81
ICPC
Pneumonia
3.7
7.4
23
64
SPAT1216
SPAT
Assessment of functional ability
2.0
7.4
84
455
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
4.3
7.3
19
46
XF600
NOMESCO Finland
Bloodpressure measurement
2.7
7.3
40
157
E0000UV, ,
ATC
1.7
7.3
202
1441
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
7.3
7
*
SPAT1325
SPAT
Vaccination
1.8
7.3
167
1130
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
7.5
7.2
16
22
X58
ICD-10 Finland
Exposure to other specified factors
2.1
7.2
72
370
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.0
7.2
86
474
NDG74
NOMESCO Finland
Fusion of first IP joint
20.4
7.2
10
5
7140B
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SERONEGATIVA]
20.4
7.2
10
5
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
20.4
7.2
10
5
B02.9
ICD-10 Finland
Zoster without complication
2.6
7.2
42
171
SPAT1231
SPAT
Assessment of adjustments needed in living environment
5.8
7.1
19
34
J05AB01
ATC
aciclovir; systemic
1.9
7.1
117
716
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.2
7.1
65
323
A03FA01
ATC
metoclopramide; systemic, rectal
1.9
7.1
116
709
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
3.6
7.1
23
66
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.6
7.1
40
160
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
7.2
7.1
16
23
Z2221
NOMESCO Finland
Medical doctor
1.8
7.0
132
842
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
4.5
7.0
17
39
NH1AD
NOMESCO Finland
Ankle and foot CT
5.6
7.0
19
35
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
6.0
7.0
18
31
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.2
6.9
27
88
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
3.2
6.9
27
88
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.7
6.8
37
145
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
2.7
6.8
37
145
A01AB10
ATC
natamycin; local oral
3.6
6.8
22
63
137
Kela drug reimbursment
Uraemia requiring dialysis
17.0
6.8
10
6
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
7.3
6.8
15
21
SPAT1153
SPAT
Removal of sutures
1.7
6.7
156
1055
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
3.0
6.7
29
100
JF1DG
NOMESCO Finland
Small bowel very extensive MRI with with high intensity magnet
22.9
6.7
9
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.1
6.7
67
345
J01FA15
ATC
telithromycin; oral
2.3
6.7
55
262
A12AA04
ATC
calcium carbonate; oral
8.0
6.7
14
18
W17
ICD-10 Finland
Other fall from one level to another
3.6
6.6
22
64
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
12.5
6.6
11
9
N05AB04
ATC
prochlorperazine; systemic, rectal
4.3
6.6
17
41
SPAT1263
SPAT
Sampling
1.7
6.6
197
1425
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.2
6.6
26
85
RK110, ,
NOMESCO Finland
10.2
6.6
12
12
M80
ICD-10 Finland
Osteoporosis with pathological fracture
10.2
6.6
12
12
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
6.6
106
644
R96
ICPC
Asthma
2.2
6.5
57
278
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
6.3
6.5
16
26
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
6.3
6.5
16
26
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
5.8
6.5
17
30
S92.3
ICD-10 Finland
Fracture of metatarsal bone
3.4
6.5
23
70
F1246, ,
NOMESCO Finland
70.8
6.4
7
*
NFJ60
NOMESCO Finland
Internal fixation of fracture of other parts of femur with intramedullary nail
14.6
6.4
10
7
J04BA02
ATC
dapsone; oral
14.6
6.4
10
7
PAW37
NOMESCO Finland
Biopsy of temporal artery
14.6
6.4
10
7
TAB00
NOMESCO Finland
Lumbar puncture
2.8
6.4
31
114
JN4CD
NOMESCO Finland
Very extensive body CT
3.3
6.4
24
76
RS221, ,
NOMESCO Finland
6.7
6.4
15
23
H20.1
ICD-10 Finland
Chronic iridocyclitis
8.3
6.4
13
16
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
8.3
6.4
13
16
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.5
6.4
22
66
E87.6
ICD-10 Finland
Hypokalaemia
3.1
6.3
26
87
B35.3
ICD-10 Finland
Tinea pedis
3.1
6.3
26
87
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
9.4
6.3
12
13
K74.3
ICD-10 Finland
Primary biliary cirrhosis
9.4
6.3
12
13
NDG76
NOMESCO Finland
Fusion of DIP joint
9.4
6.3
12
13
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.7
6.3
34
133
ZXA00
NOMESCO Finland
Right side
1.7
6.3
136
900
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
6.3
199
1457
9522
FHL
Synovectomy
27.1
6.2
8
*
L04AA17
ATC
[U] adalimumab
27.1
6.2
8
*
H02AB08
ATC
triamcinolone; systemic
27.1
6.2
8
*
Z94.2
ICD-10 Finland
Lung transplant status
27.1
6.2
8
*
WVA20, ,
SPAT
3.5
6.2
21
62
L76
ICPC
Fracture: other
3.5
6.2
21
62
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
3.0
6.2
27
94
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.3
6.2
46
210
L50.0
ICD-10 Finland
Allergic urticaria
3.9
6.1
18
48
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
4.2
6.1
16
39
S72.2
ICD-10 Finland
Subtrochanteric fracture
12.7
6.1
10
8
1370
FHL
Colonoscopy, whole colon
12.7
6.1
10
8
4930B
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA CUM EXACERBATIONE]
8.8
6.1
12
14
S01BC03
ATC
diclofenac; ophthalmic
5.3
6.1
17
33
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
10.2
6.1
11
11
4931A
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA SINE EXACERBATIONE]
10.2
6.1
11
11
JF1AD
NOMESCO Finland
Small bowel CT
10.2
6.1
11
11
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.8
6.0
30
112
B99
ICD-10 Finland
Other and unspecified infectious diseases
5.7
6.0
16
29
RD210, ,
NOMESCO Finland
6.2
6.0
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
360
1648
6.67
69.77
4.8
2.3
83.95
77.30
nmol/l
4.88
345
1447
378
1953
6.53
59.16
17.4
6.2
1.21
1.22
mmol/l
0.29
318
1664
358
1791
5.69
57.63
19.7
5.7
2.54
2.86
%
1.79
351
1667
130
299
5.69
56.17
5.5
2.9
9.71
10.29
g/l
0.64
125
275
356
1807
5.46
55.29
15.4
5.4
1.21
1.22
mmol/l
0.14
341
1639
359
1841
5.50
54.83
20.2
5.8
23.92
28.21
%
10.34
352
1722
395
2236
6.81
52.08
22.2
9.0
4.83
4.03
e9/l
6.18
379
1957
166
505
4.60
50.66
3.3
2.2
20.37
22.18
%
0.75
142
426
138
364
5.01
50.37
3.0
1.7
320.53
368.51
nmol/l
0.76
127
334
168
529
4.45
48.76
3.3
2.1
2.26
2.37
g/l
1.49
160
483
175
583
4.25
46.81
3.5
2.1
11.36
13.00
umol/l
1.97
167
528
112
265
5.28
46.21
2.3
1.6
—
—
—
0
0
224
909
3.88
44.78
3.5
2.1
3.40
3.21
mg/l
0.53
205
770
120
324
4.67
41.90
1.9
3.1
64.22
67.07
g/l
3.16
111
295
71
122
6.71
40.94
4.3
2.5
—
—
—
0
0
50
61
9.09
38.82
4.4
3.0
4.86
4.50
e9/l
0.31
50
61
53
71
8.32
38.15
8.7
6.5
789.08
470.92
iu/ml
0.18
12
12
50
63
8.79
37.82
4.8
3.5
61.50
58.75
%
0.54
50
63
308
1687
3.56
36.05
11.1
4.3
33.64
35.68
g/l
7.74
299
1570
161
609
3.54
34.22
2.6
1.9
—
—
—
0
0
162
617
3.52
34.04
7.4
3.1
0.80
0.82
mmol/l
0.97
157
576
125
408
3.85
33.09
4.9
2.6
1.93
1.82
%
0.56
116
362
123
405
3.79
32.05
5.3
4.4
270.50
265.50
u/l
0.07
114
378
418
3021
5.72
28.00
21.5
7.2
73.32
78.47
u/l
2.23
413
2814
33
39
9.05
26.07
2.2
1.5
—
—
—
0
0
245
1344
2.78
25.37
4.8
3.3
2.32
2.36
mmol/l
5.65
219
1167
249
1379
2.78
25.28
7.2
3.0
—
—
—
0
0
57
126
5.03
24.80
2.5
1.5
121.43
166.67
titre
—
7
6
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
49
98
5.48
23.85
8.9
2.5
0.26
0.37
u/ml
1.77
32
56
392
2850
3.71
22.65
13.1
4.2
15.99
12.43
mm/h
4.69
380
2600
55
129
4.71
22.25
1.8
1.6
0.06
0.16
iu/ml
—
6
20
318
2076
2.77
22.08
11.8
5.9
11.36
11.28
umol/l
0.03
311
1958
292
1828
2.67
22.07
21.9
13.2
1.33
1.21
inr
1.13
96
539
113
439
3.09
21.87
11.3
6.6
10.87
12.24
kpa
2.95
108
422
43
83
5.62
21.71
2.1
1.3
—
—
—
0
0
263
1580
2.57
21.43
5.2
2.6
199.48
113.60
ug/l
1.30
247
1436
75
229
3.72
21.30
5.3
3.4
1.53
2.02
mmol/l
0.48
64
172
111
435
3.05
21.09
2.7
1.9
—
—
—
0
0
61
162
4.19
21.04
2.2
2.2
1.61
1.57
g/l
0.10
49
141
74
226
3.72
20.99
1.8
1.3
139.60
261.16
u/ml
0.47
69
205
111
438
3.03
20.82
11.6
6.6
0.81
1.31
mmol/l
0.47
96
366
24
5
50.49
20.35
1.7
1.8
—
—
—
0
0
163
797
2.63
20.24
5.3
2.4
5.15
6.54
e6/l
0.45
153
718
61
167
4.06
20.17
6.3
2.1
35.72
39.74
u/l
0.67
56
147
335
2297
2.74
20.17
11.6
4.4
6.59
6.63
mmol/l
0.17
328
2145
46
102
4.90
19.86
1.3
1.2
—
—
—
0
0
48
111
4.72
19.71
2.1
1.5
—
—
—
0
0
108
438
2.92
19.15
2.8
1.9
—
—
—
0
0
49
122
4.38
18.33
1.5
4.3
27.95
108.70
mg/l
0.94
40
101
42
95
4.77
17.68
2.1
1.6
—
—
—
0
0
203
1158
2.36
17.50
7.2
3.1
19.55
116.87
e6/l
1.03
173
879
48
122
4.28
17.47
1.5
4.3
24.32
28.74
mg/l
0.56
38
100
110
474
2.74
17.25
5.2
2.3
236.33
115.09
ug/g
2.85
94
377
35
69
5.41
17.22
2.1
1.6
—
—
—
0
0
89
347
2.95
16.80
13.2
3.3
1.63
2.11
mmol/l
0.65
77
288
151
767
2.45
16.79
2.5
1.5
2.08
2.47
g/l
1.39
116
442
50
135
4.04
16.79
5.7
1.8
—
—
—
0
0
46
120
4.15
16.16
1.5
4.2
2.31
2.53
ratio
—
6
12
143
725
2.42
15.83
2.0
1.7
1263.10
1214.60
nmol/l
0.13
110
529
90
365
2.83
15.74
3.6
2.1
0.21
0.22
g/l
0.43
84
343
41
100
4.41
15.71
2.2
1.5
—
—
—
0
0
198
1157
2.26
15.71
5.8
3.1
1899.26
1082.57
ng/l
1.20
181
971
107
475
2.64
15.69
18.3
6.1
103.81
104.15
mmol/l
0.29
107
475
27
22
12.97
15.56
2.5
2.6
—
—
—
0
0
205
1220
2.24
15.50
4.0
2.3
57.15
63.12
u/l
0.54
188
1105
186
1068
2.25
15.31
6.8
3.0
0.32
0.53
e6/l
0.99
157
792
57
180
3.48
15.23
17.1
3.1
23.93
24.29
mmol/l
0.40
57
175
46
130
3.82
14.47
1.7
1.3
4.48
2.57
u/ml
—
6
11
33
73
4.80
14.24
2.0
1.5
—
—
—
0
0
35
82
4.54
14.09
2.5
1.7
5.70
4.42
mmol/24h
1.55
29
70
28
54
5.46
14.08
1.4
1.3
115.50
107.00
u/ml
—
6
8
233
1512
2.11
13.60
6.1
3.7
40.20
59.60
ng/l
0.34
195
1073
25
45
5.82
13.51
2.4
1.4
—
—
—
0
0
22
35
6.55
13.40
1.3
1.5
—
—
—
0
0
27
53
5.35
13.32
2.0
1.5
—
—
—
0
0
195
1196
2.10
13.09
3.4
2.1
267.08
187.21
u/l
0.20
189
1126
161
921
2.16
12.94
3.6
2.2
—
—
—
0
0
88
393
2.54
12.55
4.1
3.3
—
—
—
0
0
36
95
4.03
12.43
2.0
1.6
23773.30
23853.75
e6/l
0.00
30
63
335
2551
2.19
12.15
8.9
4.4
111.20
2810.08
e6/l
—
10
39
44
138
3.42
11.84
2.1
1.7
—
—
—
0
0
22
40
5.73
11.75
1.0
1.2
—
—
—
0
0
20
17
12.25
11.43
4.6
2.8
626.80
673.59
u/ml
0.09
20
17
15
6
25.77
11.20
1.5
2.2
—
—
—
0
0
256
1804
1.96
11.03
4.2
2.5
—
—
—
0
0
30
76
4.16
10.93
2.5
2.2
117.05
129.56
g/l
1.98
19
50
148
865
2.05
10.92
3.9
1.7
1.71
1.13
mg/l
1.10
122
675
266
1903
1.96
10.92
6.5
3.7
0.01
0.00
estimate
0.36
76
381
29
72
4.23
10.85
3.0
2.3
15.22
15.51
%
0.16
17
32
24
51
4.91
10.83
1.3
1.1
—
—
—
0
0
41
133
3.29
10.46
1.9
1.6
—
—
—
0
0
26
61
4.46
10.44
2.2
1.4
—
—
—
0
0
265
1911
1.93
10.43
8.8
5.0
0.00
0.00
estimate
-0.00
74
358
30
79
3.99
10.38
1.8
1.5
—
—
—
0
0
267
1934
1.92
10.32
6.6
3.7
0.00
0.01
estimate
0.50
70
349
26
62
4.39
10.23
1.3
1.1
268.63
280.97
u/ml
0.06
16
35
34
99
3.63
10.23
1.7
1.4
—
—
—
0
0
28
71
4.14
10.19
2.2
1.6
—
—
—
0
0
28
71
4.14
10.19
2.2
1.6
—
—
—
0
0
154
933
1.98
10.15
1.9
1.5
20.32
21.34
nmol/l
0.34
129
778
24
54
4.64
10.14
1.4
1.1
1.45
1.26
u/ml
0.49
11
19
44
152
3.10
10.12
1.8
2.2
—
—
—
0
0
89
439
2.28
10.04
6.2
2.6
6.54
7.67
umol/l
0.38
78
385
20
39
5.32
9.92
1.8
1.8
61.85
65.88
%
0.16
13
26
39
127
3.27
9.89
2.1
2.6
1.61
0.55
g/l
0.86
33
114
66
288
2.51
9.78
4.5
3.3
244.67
181.74
ng/l
0.30
58
262
25
61
4.28
9.56
1.6
1.5
—
—
—
0
0
188
1240
1.88
9.47
8.6
3.1
37.36
31.46
u/l
0.68
179
1174
26
66
4.12
9.45
1.3
1.1
—
—
—
0
0
54
217
2.69
9.45
1.8
1.7
—
—
—
0
0
20
25
8.31
9.44
1.3
1.2
0.16
4.01
u/ml
0.56
14
14
28
76
3.86
9.30
1.7
1.3
—
—
—
0
0
28
76
3.86
9.30
1.7
1.3
—
—
—
0
0
123
711
2.00
9.14
6.2
3.9
1171.62
372.39
ng/l
0.39
100
553
16
14
11.80
9.13
7.9
4.6
—
—
—
0
0
156
979
1.90
9.09
4.7
2.5
2870.67
8116.09
umol/l
1.05
136
834
23
56
4.27
8.82
1.6
1.5
—
—
—
0
0
108
605
2.03
8.72
6.0
2.9
2.03
2.66
e6/l
0.52
67
311
56
240
2.52
8.60
1.5
1.4
—
—
—
0
0
21
50
4.35
8.28
3.5
3.9
—
—
—
0
0
427
3795
3.03
8.12
45.9
13.9
20.97
23.01
mg/l
0.77
399
2991
34
116
3.09
7.99
1.9
1.2
3.36
2.80
u/ml
—
5
16
34
117
3.06
7.88
1.9
1.2
21.82
2.35
u/ml
—
9
20
16
19
8.68
7.87
1.9
1.3
—
—
—
0
0
18
40
4.64
7.71
1.6
1.7
—
—
—
0
0
122
747
1.87
7.46
3.2
3.0
2.46
2.45
mmol/l
0.47
113
656
110
653
1.90
7.40
5.4
2.7
0.84
1.12
e6/l
0.53
71
355
173
1185
1.74
7.23
4.4
3.1
6.14
7.21
mmol/l
2.74
152
983
10
5
20.40
7.16
1.4
1.2
—
—
—
0
0
30
103
3.05
6.99
2.3
1.7
—
—
—
0
0
18
44
4.22
6.87
1.6
1.7
—
—
—
0
0
14
18
7.99
6.66
1.2
1.2
1.02
1.07
ratio
—
6
7
26
87
3.11
6.33
2.0
1.2
72.11
35.90
u/ml
—
8
9
19
52
3.77
6.26
2.6
1.5
—
—
—
0
0
19
52
3.77
6.26
2.6
1.5
—
—
—
0
0
33
128
2.70
6.19
1.7
1.5
—
—
—
0
0
7
302
0.22
5.97
1.4
1.7
—
—
—
0
0
197
1452
1.63
5.96
6.7
3.9
—
—
—
0
0
150
1036
1.67
5.84
7.5
4.0
0.00
0.00
estimate
0.50
73
356
211
1588
1.61
5.82
2.5
2.0
97.82
97.85
pmol/l
0.00
129
757
18
50
3.71
5.81
1.5
1.5
—
—
—
0
0
131
874
1.70
5.81
1.3
1.3
0.55
1.67
u/ml
2.65
40
227
18
51
3.63
5.66
1.5
1.5
—
—
—
0
0
18
51
3.63
5.66
1.5
1.5
—
—
—
0
0
105
663
1.76
5.65
1.4
1.3
24.50
33.67
iu/ml
0.85
29
216
9
7
13.08
5.60
2.4
1.4
—
—
—
0
0
102
644
1.75
5.48
1.3
1.3
15.60
12.53
u/ml
0.13
34
246
24
84
2.96
5.44
1.4
1.4
—
—
—
0
0
18
53
3.49
5.36
1.3
1.1
—
—
—
0
0
123
825
1.67
5.29
1.7
1.7
438.47
447.14
pmol/l
0.12
102
672
31
127
2.55
5.25
1.5
1.4
208.59
288.82
ug/g
1.24
15
77
5
0
+∞
5.22
3.0
0.0
2.42
—
mg/l
—
5
0
17
50
3.49
5.07
1.5
1.5
—
—
—
0
0
17
50
3.49
5.07
1.5
1.5
—
—
—
0
0
65
368
1.89
4.96
3.7
2.3
35.97
30.73
u/l
0.68
59
314
17
51
3.42
4.93
1.5
1.5
—
—
—
0
0
16
38
4.33
4.87
1.8
1.3
3963.91
1599.54
e6/l
0.41
11
24
8
7
11.60
4.80
1.0
1.0
—
—
—
0
0
10
14
7.28
4.67
2.2
1.7
28.80
30.71
umol/l
—
10
14
16
48
3.42
4.64
1.6
1.4
—
—
—
0
0
14
31
4.63
4.59
1.9
1.4
—
—
—
0
0
14
31
4.63
4.59
1.1
1.1
—
—
u/ml
—
0
0
9
11
8.32
4.58
1.3
1.4
—
—
—
0
0
8
8
10.15
4.53
1.4
1.1
—
—
—
0
0
13
27
4.92
4.53
1.4
1.3
—
—
—
0
0
58
329
1.87
4.40
2.2
2.5
9.73
6.37
ug/l
0.47
51
285
9
12
7.62
4.37
1.3
2.2
—
—
—
0
0
9
12
7.62
4.37
1.3
2.2
—
—
—
0
0
9
13
7.04
4.18
1.3
2.1
—
—
—
0
0
11
21
5.34
4.16
1.9
1.2
—
—
—
0
0
14
35
4.09
4.13
1.6
1.3
3386.63
26555.58
e6/l
—
8
19
11
22
5.10
4.02
1.9
1.2
—
—
—
0
0
10
18
5.65
3.99
1.4
1.3
—
—
—
0
0
10
18
5.65
3.99
1.4
1.3
—
—
—
0
0
266
2220
1.48
3.99
3.0
2.8
—
—
—
0
0
292
2483
1.49
3.98
6.1
3.1
81.59
47.90
u/l
1.68
276
2294
15
48
3.20
3.96
3.0
1.8
33.33
32.17
pg
0.47
15
48
20
76
2.71
3.95
1.9
3.3
1.03
0.76
nmol/l
0.93
13
60
13
32
4.15
3.93
1.2
1.1
—
—
—
0
0
24
102
2.43
3.81
1.7
1.2
—
—
—
0
0
14
39
3.67
3.73
2.8
2.3
—
—
—
0
0
11
25
4.48
3.64
1.9
1.3
—
—
—
0
0
395
3623
1.68
3.52
36.4
13.2
78.81
79.50
ml/min/173m2
0.22
357
2947
8
13
6.24
3.51
1.3
1.0
—
—
—
0
0
6
6
10.11
3.50
1.3
1.2
—
—
—
0
0
424
3974
1.98
3.44
45.1
16.0
139.25
139.71
mmol/l
2.70
417
3868
7
10
7.09
3.37
2.9
1.1
2.49
2.11
mmol/l
—
7
10
17
65
2.68
3.34
1.3
1.3
—
—
—
0
0
10
23
4.42
3.32
1.6
1.1
—
—
—
0
0
10
23
4.42
3.32
1.4
1.4
—
—
—
0
0
10
23
4.42
3.32
1.4
1.4
—
—
—
0
0
424
3982
1.95
3.30
45.7
16.1
3.92
3.97
mmol/l
3.61
417
3870
336
2989
1.47
3.27
5.1
4.0
15.26
14.85
pmol/l
2.11
304
2688
9
19
4.81
3.25
1.3
1.8
—
—
—
0
0
9
19
4.81
3.25
1.3
1.8
—
—
—
0
0
13
39
3.40
3.25
1.3
1.6
—
—
—
0
0
13
39
3.40
3.25
1.3
1.6
—
—
—
0
0
13
39
3.40
3.25
1.3
1.6
—
—
—
0
0
10
24
4.24
3.21
1.2
1.2
—
—
—
0
0
7
11
6.44
3.19
1.0
1.2
153.43
101.66
iu/ml
—
7
11
14
51
2.80
3.01
1.3
1.1
—
—
—
0
0
153
1201
1.41
2.95
4.8
3.8
15.48
6.24
mg/mmol
1.39
96
731
6
9
6.74
2.87
4.0
1.1
3.45
3.80
umol/l
—
6
9
12
38
3.22
2.87
1.3
1.1
—
—
—
0
0
430
4084
1.96
2.81
29.2
10.5
29.87
25.90
u/l
0.69
425
3931
10
28
3.63
2.80
2.2
3.1
—
—
—
0
0
51
320
1.67
2.78
4.3
2.7
56.93
65.20
ml/min/173m2
0.80
30
127
20
91
2.25
2.77
2.1
1.8
1.83
5.78
iu/l
—
9
29
11
34
3.29
2.74
1.2
1.1
—
—
—
0
0
11
34
3.29
2.74
1.2
1.1
—
—
—
0
0
6
10
6.06
2.70
1.0
1.0
—
—
—
0
0
9
24
3.80
2.68
1.2
1.0
—
—
—
0
0
11
35
3.19
2.66
1.2
1.1
—
—
—
0
0
11
35
3.19
2.66
1.2
1.1
—
—
—
0
0
11
35
3.19
2.66
1.2
1.1
—
—
—
0
0
7
15
4.72
2.60
1.3
1.1
—
—
—
0
0
5
7
7.21
2.55
1.0
1.0
108.60
92.14
%
—
5
7
11
37
3.02
2.50
1.2
1.2
—
—
—
0
0
11
37
3.02
2.50
1.2
1.2
—
—
—
0
0
11
37
3.02
2.50
2.7
2.0
—
—
—
0
0
9
26
3.51
2.49
2.4
1.3
0.90
1.06
g/l
—
9
26
63
430
1.54
2.45
3.7
4.1
10.60
32.25
ug/l
0.61
56
365
5
8
6.30
2.37
3.0
2.5
302.40
160.50
%
—
5
8
7
17
4.16
2.37
2.1
2.2
—
—
—
0
0
19
92
2.11
2.30
1.2
1.1
—
—
—
0
0
10
34
2.98
2.29
1.0
1.1
—
—
—
0
0
6
13
4.66
2.28
1.0
1.0
—
—
—
0
0
8
25
3.24
2.10
5.5
2.9
—
—
—
0
0
10
37
2.74
2.08
1.0
1.1
—
—
—
0
0
6
16
3.78
1.94
1.3
1.0
—
—
—
0
0
13
58
2.28
1.92
2.1
1.4
—
—
—
0
0
7
22
3.21
1.88
4.6
1.7
—
—
—
0
0
7
22
3.21
1.88
4.6
1.7
—
—
—
0
0
69
509
1.42
1.85
4.5
4.6
33.26
32.77
%
0.13
50
323
6
17
3.56
1.84
1.3
1.3
—
—
—
0
0
375
3520
1.37
1.80
6.2
5.0
1.90
2.28
mu/l
0.55
345
3196
7
23
3.07
1.80
1.0
1.2
—
—
—
0
0
357
3779
0.74
1.79
5.0
4.6
1.56
1.52
mmol/l
0.91
323
3456
17
88
1.97
1.77
1.2
1.3
—
—
—
0
0
5
15
3.36
1.52
9.4
2.1
224.80
209.07
u/l
—
5
15
22
131
1.71
1.52
1.4
1.2
—
—
—
0
0
7
27
2.62
1.52
1.1
1.4
88.29
72.63
umol/l
—
7
27
101
820
1.30
1.48
7.1
4.1
1.02
1.02
kg/l
0.14
19
104
9
38
2.40
1.46
2.0
1.4
—
—
—
0
0
9
41
2.22
1.37
1.4
1.2
—
81.83
—
0
6
10
47
2.15
1.34
1.0
1.1
—
—
—
0
0
347
3648
0.79
1.26
4.5
4.1
1.44
1.28
mmol/l
2.68
314
3310
10
49
2.06
1.23
1.1
1.1
—
—
—
0
0
21
132
1.62
1.22
1.4
1.2
—
—
—
0
0
5
19
2.65
1.22
1.4
1.6
—
—
—
0
0
364
3800
0.79
1.19
5.0
4.6
4.71
4.72
mmol/l
0.11
336
3493
6
26
2.32
1.19
1.0
1.2
1.95
1.90
mmol/l
—
6
26
48
626
0.74
1.18
1.5
1.4
—
—
—
0
0
0
34
0.00
1.16
0.0
1.0
—
36.17
—
0
20
0
34
0.00
1.16
0.0
1.0
—
664.00
—
0
20
372
3871
0.79
1.15
5.2
5.2
2.66
2.78
mmol/l
1.67
337
3532
5
111
0.44
1.14
1.8
1.4
—
—
—
0
0
20
304
0.64
1.13
2.0
2.0
—
—
—
0
0
7
30
2.35
1.12
1.0
1.1
—
—
—
0
0
433
4224
1.52
1.11
61.4
20.6
38.50
40.15
%
6.31
412
3951
433
4226
1.51
1.08
59.3
20.6
4.26
4.47
e12/l
13.93
426
4092
52
405
1.32
1.05
2.0
1.8
1.52
1.52
%
0.01
43
358
12
70
1.73
0.93
4.0
2.0
79.67
8101.71
u/l
—
6
30
26
191
1.38
0.79
1.1
1.0
—
—
—
0
0
0
26
0.00
0.78
0.0
1.3
—
174.67
—
0
26
14
91
1.56
0.76
1.2
1.4
199.33
291.83
miu/ml
—
6
38
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
24
2.09
0.74
1.0
1.2
—
—
—
0
0
5
24
2.09
0.74
1.0
1.1
—
—
—
0
0
61
723
0.82
0.73
4.7
4.3
20.23
21.03
%
0.17
26
342
20
275
0.71
0.73
1.5
1.8
—
—
—
0
0
5
26
1.93
0.71
3.2
1.9
—
—
—
0
0
11
69
1.61
0.69
1.8
1.8
178.91
231.49
pmol/l
1.33
11
63
5
28
1.79
0.66
1.0
1.4
—
62.00
—
0
5
43
515
0.82
0.59
2.7
2.9
0.51
0.73
ug/l
2.14
28
336
10
68
1.48
0.47
1.3
1.3
211.17
17.23
u/l
—
10
57
31
258
1.22
0.43
1.4
1.2
165.26
130.42
iu/ml
—
10
103
6
91
0.65
0.42
1.7
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
389.89
—
0
9
14
106
1.33
0.39
1.3
1.8
—
—
—
0
0
382
3749
1.12
0.36
5.1
4.7
5.66
5.96
mmol/l
4.55
345
3412
366
3586
1.11
0.34
6.7
5.9
39.83
39.88
mmol/mol
0.03
338
3310
7
53
1.33
0.31
1.4
1.5
236.43
367.31
pmol/l
—
7
48
17
138
1.24
0.31
1.3
1.8
—
—
—
0
0
24
203
1.19
0.30
1.5
1.3
—
—
—
0
0
66
605
1.11
0.29
1.4
1.4
—
—
—
0
0
17
140
1.22
0.28
8.0
1.9
12.80
3.04
mg/l
0.87
17
102
10
126
0.79
0.24
1.3
1.6
—
—
—
0
0
14
116
1.21
0.22
1.5
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
53
502
1.06
0.13
9.4
7.6
—
—
—
0
0
87
887
0.98
0.05
5.4
4.7
1.38
2.43
ug/l
2.11
77
792
13
121
1.08
0.03
1.3
1.3
—
—
—
0
0
108
1088
0.99
0.01
1.7
1.6
1.65
1.37
mmol/l
1.32
93
911
0
7
0.00
0.00
0.0
3.7
—
63.54
—
0
7
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
26.18
—
0
6
8
81
0.99
-0.00
1.5
1.6
363.75
315.64
mu/l
—
8
76
0
6
0.00
-0.00
0.0
8.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint DRUGADVERS_OSTEOPO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_OSTEOPO | 2.759 [2.28, 3.34] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.848 |
During the follow-up period (1.1.1998 — 31.12.2019), 395 out of 1151 females with DRUGADVERS_OSTEOPO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_OSTEOPO | 3.158 [2.41, 4.14] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 217 out of 617 males with DRUGADVERS_OSTEOPO died.
Mortality risk
Mortality risk for people of age
years, who have DRUGADVERS_OSTEOPO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.322% | 0.638% |
| 5 | 1.866% | 4.02% |
| 10 | 4.474% | 9.482% |
| 15 | 8.094% | 17.051% |
| 20 | 15.429% | 26.671% |
Relationships between endpoints
↥Index endpoint: DRUGADVERS_OSTEOPO – Drug-induced osteoporosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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