thyroid disease: A disease involving the thyroid gland.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
461 |
4. Check minimum number of eventsNone |
461 |
5. Include endpointsNone |
461 |
6. Filter based on genotype QC (FinnGen only) |
461 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorder of thyroid, unspecified
based on the number of shared cases.
Similar with more cases:
- Other disorders of thyroid
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3547 | 2760 | 749 |
| Only index persons | 2885 | 2275 | 610 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.08 | 0.02 |
| Only index persons | 0.07 | 0.08 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 47.04 | 46.23 | 49.67 |
| Only index persons | 43.39 | 42.46 | 46.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 461 | 379 | 82 |
| Unadjusted period prevalence (%) | 0.11 | 0.13 | 0.04 |
| Median age at first event (years) | 43.64 | 41.67 | 52.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 392
- Matched controls
- 3921
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
2601.8
175.9
157
*
H03AA01
ATC
levothyroxine sodium; systemic
71.9
171.5
193
52
24599
ICD-8 Finland
Thyroiditis, Unspecified
+∞
139.0
125
*
104
Kela drug reimbursment
Thyroid insufficiency
1094.6
91.7
86
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
159.0
84.9
87
7
E07.89
ICD-10 Finland
Other specified disorders of thyroid
+∞
74.4
69
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
173.1
44.8
46
*
E03
ICD-10 Finland
Other hypothyroidism
179.6
32.2
33
*
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
65.8
31.6
36
6
E03.89
ICD-10 Finland
Other specified hypothyroidism
119.7
31.2
33
*
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
289.8
27.1
27
*
H03BB01
ATC
carbimazole; oral
289.8
27.1
27
*
BAA60
NOMESCO Finland
Total thyroidectomy
243.6
22.9
23
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
22.1
21
*
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
33.3
21.8
28
9
T86
ICPC
Hypothyroidism/myxoedema
39.6
21.0
26
7
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
+∞
21.0
20
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
17.8
17
*
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
+∞
15.7
15
*
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
51.8
12.9
15
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.4
12.7
38
76
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
22.1
12.1
17
8
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
18.5
10.8
16
9
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
112.9
10.5
11
*
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
10.5
10
*
E07.82
ICD-10 Finland
Disorder of thyroid function caused by general disease state
+∞
10.5
10
*
E07.81
ICD-10 Finland
Pituitary thyroxin resistence
+∞
10.5
10
*
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
+∞
10.5
10
*
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
16.6
10.4
16
10
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
33.5
10.4
13
*
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
+∞
9.4
9
*
2469X
ICD-9 Finland
Other disorders of thyroid, Unspecified disorder of thyroid
+∞
8.4
8
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
8.4
8
*
E07.8
ICD-10 Finland
Other specified disorders of thyroid
+∞
8.4
8
*
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
81.6
7.4
8
*
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
+∞
7.3
7
*
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
30.6
7.2
9
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
6.6
117
724
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
6.4
147
991
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
6.3
147
992
24210
ICD-8 Finland
Thyrotoxicosis with or without goitre, Toxic nodular goitre
+∞
6.3
6
*
E07.80
ICD-10 Finland
Pituitary thyroxin resistence
+∞
6.3
6
*
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
+∞
6.3
6
*
C73.92
ICD-10 Finland
Follicular carcinoma of the thyroid gland
+∞
6.3
6
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.8
6.2
122
777
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYROIDNASOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDNASOTH | 1.444 [1.16, 1.8] | 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.115 |
During the follow-up period (1.1.1998 — 31.12.2019), 162 out of 1145 females with E4_THYROIDNASOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDNASOTH | 0.919 [0.68, 1.25] | 0.585 |
| Birth year | 0.988 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 66 out of 391 males with E4_THYROIDNASOTH died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYROIDNASOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.15% | 0.156% |
| 5 | 0.893% | 1.064% |
| 10 | 2.105% | 2.826% |
| 15 | 3.935% | 5.346% |
| 20 | 6.989% | 8.95% |
Relationships between endpoints
↥Index endpoint: E4_THYROIDNASOTH – Disorder of thyroid, unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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