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R13

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Disorder of thyroid, unspecified

DOID EFO Endpoint Browser PheWeb

E4_THYROIDNASOTH

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

498

4. Check minimum number of events

None

498

5. Include endpoints

None

498

6. Filter based on genotype QC (FinnGen only)

480

Control definitions (FinnGen only)

Control exclude
E4_THYROID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3547 2760 749
Only index persons 2885 2275 610
Unadjusted period prevalence (%)
Whole population 0.07 0.08 0.02
Only index persons 0.07 0.08 0.02
Median age at first event (years)
Whole population 47.04 46.23 49.67
Only index persons 43.39 42.46 46.83

-FinnGen-

Key figures

All Female Male
Number of individuals 480 394 86
Unadjusted period prevalence (%) 0.12 0.14 0.04
Median age at first event (years) 45.83 44.22 53.20

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
498
Matched controls
4980
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H03AA01
ATC
levothyroxine sodium; systemic
80.0
307.7
258
66
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
162.9
266.6
132
11
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
+∞
248.4
217
*
24599
ICD-8 Finland
Thyroiditis, Unspecified
+∞
156.8
142
*
104
Kela drug reimbursment
Thyroid insufficiency
464.7
112.2
108
*
E07.89
ICD-10 Finland
Other specified disorders of thyroid
+∞
101.6
94
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
322.3
57.5
57
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
101.0
57.4
62
7
E03
ICD-10 Finland
Other hypothyroidism
132.5
45.6
48
*
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
84.4
41.7
46
6
T86
ICPC
Hypothyroidism/myxoedema
96.4
40.5
44
5
BAA60
NOMESCO Finland
Total thyroidectomy
395.5
37.5
37
*
H03BB01
ATC
carbimazole; oral
86.9
36.4
40
5
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
35.9
34
*
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
99.8
34.2
37
*
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
42.1
31.7
39
10
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
26.3
25
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
136.9
24.8
26
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.9
22.5
52
115
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
104.0
18.7
20
*
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
21.0
17.9
26
13
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
15.7
15
*
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
24.3
15.2
21
9
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
+∞
14.7
14
*
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
154.3
14.5
15
*
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
154.3
14.5
15
*
E07.81
ICD-10 Finland
Pituitary thyroxin resistence
+∞
12.5
12
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
133.2
12.5
13
*
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
10.4
12.1
23
23
2469X
ICD-9 Finland
Other disorders of thyroid, Unspecified disorder of thyroid
+∞
11.5
11
*
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
28.7
10.8
14
5
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
112.3
10.5
11
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
10.4
10
*
E07.82
ICD-10 Finland
Disorder of thyroid function caused by general disease state
+∞
10.4
10
*
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
+∞
10.4
10
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
10.1
197
1289
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
9.7
86
423
E07.8
ICD-10 Finland
Other specified disorders of thyroid
+∞
9.4
9
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
9.3
199
1332
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
8.4
8
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.8
8.2
166
1085
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
3.8
8.1
25
69
2504
FHL
Unilateral resection or enucleation
33.9
8.1
10
*
R07.0
ICD-10 Finland
Pain in throat
2.8
7.8
40
151
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
+∞
7.3
7
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
7.3
151
988
R94.6
ICD-10 Finland
Abnormal results of thyroid function studies
20.4
7.2
10
5
WX402
NOMESCO Finland
General anaesthesia
1.9
7.0
109
654
A04
ICPC
Weakness/tiredness general
2.0
6.8
78
421
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
40.6
6.8
8
*
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
40.6
6.8
8
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.8
6.5
33
124
R06.0
ICD-10 Finland
Dyspnoea
1.7
6.5
137
896
R49.08
ICD-10 Finland
Other specified dysphonia
4.0
6.5
18
46
A02BC02
ATC
pantoprazole; systemic
1.7
6.5
330
2702
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
6.4
127
815
24210
ICD-8 Finland
Thyrotoxicosis with or without goitre, Toxic nodular goitre
70.7
6.4
7
*
BAA20
NOMESCO Finland
Unilateral partial excision of thyroid gland
70.7
6.4
7
*
R53
ICD-10 Finland
Malaise and fatigue
1.7
6.3
122
779
6481B
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Thyroid dysfunction[HYPOTHYREOSIS IN GRAVIDITATE]
+∞
6.3
6
*
E07.80
ICD-10 Finland
Pituitary thyroxin resistence
+∞
6.3
6
*
E06.9
ICD-10 Finland
Thyroiditis, unspecified
+∞
6.3
6
*
C73.92
ICD-10 Finland
Follicular carcinoma of the thyroid gland
+∞
6.3
6
*
2468X
ICD-9 Finland
Other disorders of thyroid, Other specified disorders of thyroid[MORBUS GLANDULAE THYREOIDEAE ALIUD]
+∞
6.3
6
*
R21
ICPC
Throat symptom/complaint
1.8
6.1
106
654
J01AA02
ATC
doxycycline; systemic
1.7
6.1
386
3313
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
12.7
6.1
10
8
Z2221
NOMESCO Finland
Medical doctor
1.7
6.1
141
945

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
111
116
12.03
98.94
4.1
1.4
4.75
4.39
pmol/l
1.69
106
103
76
195
4.42
27.53
1.4
1.2
146.46
71.42
iu/ml
0.88
27
68
427
3101
3.64
24.53
7.6
2.6
15.60
14.43
pmol/l
9.54
408
2785
456
3762
3.52
15.07
9.0
3.5
1.93
1.89
mu/l
0.08
435
3413
288
1951
2.13
15.00
8.7
5.4
1.22
1.22
mmol/l
0.18
257
1669
203
1257
2.04
12.92
2.0
2.1
—
—
—
0
0
76
311
2.70
12.85
2.3
1.9
371.97
358.63
nmol/l
0.23
71
284
258
1764
1.96
12.14
8.4
4.7
1.22
1.22
mmol/l
0.30
241
1602
190
1184
1.98
11.60
4.5
3.3
7.39
7.40
ph
0.36
31
225
384
3055
2.12
11.25
4.7
4.1
11.94
12.14
mm/h
0.10
364
2809
161
961
2.00
11.02
1.9
2.1
—
—
—
0
0
64
269
2.58
10.20
2.6
2.8
68.79
80.40
ng/l
0.73
55
237
83
396
2.32
10.04
2.0
2.5
5.50
6.27
umol/l
0.34
72
333
261
1875
1.82
9.78
2.5
2.4
—
—
—
0
0
205
1376
1.83
9.54
3.0
3.2
2.35
2.36
mmol/l
0.70
188
1214
242
1737
1.76
8.77
2.6
2.2
79.27
78.29
nmol/l
0.23
227
1550
263
1943
1.75
8.54
5.7
5.5
29.42
28.38
%
0.82
248
1801
256
1906
1.71
7.84
5.9
5.6
8.45
8.39
%
0.11
242
1766
235
1715
1.70
7.71
2.1
2.0
—
—
—
0
0
247
1829
1.70
7.66
5.6
5.5
0.66
0.70
%
0.68
232
1681
253
1898
1.68
7.37
5.7
5.4
3.13
2.72
%
2.23
239
1747
119
731
1.83
7.06
3.5
3.5
707.34
208.62
ng/l
0.35
80
542
254
1922
1.66
7.05
5.5
5.3
55.54
57.13
%
1.39
239
1782
103
611
1.86
6.81
2.1
2.7
2.54
3.38
e6/l
0.43
44
292
267
2084
1.61
6.27
5.5
5.6
0.20
0.18
e9/l
1.94
236
1827
370
3139
1.70
6.12
7.2
6.8
74.95
76.92
u/l
0.56
357
2935
222
1665
1.60
6.11
4.7
3.9
36.54
35.74
g/l
1.55
211
1544
330
2729
1.62
5.94
4.9
4.6
6.00
3757.43
e6/l
—
5
37
242
1868
1.57
5.80
5.8
5.9
—
—
—
0
0
215
1619
1.58
5.71
2.3
1.9
101.27
95.26
pmol/l
0.95
110
767
255
2003
1.56
5.59
5.5
5.4
0.58
0.56
e9/l
0.54
222
1730
450
4080
2.07
5.55
15.7
12.7
20.84
22.94
mg/l
0.70
368
3161
255
2012
1.55
5.41
5.5
5.3
0.04
0.04
e9/l
0.20
221
1736
456
4164
2.13
5.35
19.7
14.3
139.52
139.72
mmol/l
0.88
447
4039
28
108
2.69
5.32
2.6
3.9
—
—
—
0
0
259
2059
1.54
5.26
5.6
5.4
1.97
1.90
e9/l
0.36
231
1825
281
2274
1.54
5.26
6.9
4.0
6.52
6.54
mmol/l
0.06
260
2112
456
4175
2.09
5.14
20.0
14.3
3.93
3.95
mmol/l
0.47
446
4038
145
1026
1.58
4.89
6.3
6.4
—
—
—
0
0
110
734
1.64
4.70
1.7
1.6
1021.11
1229.61
nmol/l
1.29
92
538
113
763
1.62
4.60
3.2
2.8
2.44
2.46
mmol/l
0.74
97
667
190
1453
1.50
4.42
3.5
3.5
15.40
68.77
e6/l
5.90
120
990
282
2336
1.48
4.37
7.8
8.7
3.85
4.04
e9/l
0.87
245
2033
228
1813
1.48
4.34
3.4
2.6
105.26
103.81
ug/l
0.02
212
1659
163
1212
1.51
4.32
2.9
3.0
38.05
125.39
e6/l
0.77
115
912
62
366
1.79
4.12
2.4
2.1
35.98
33.88
u/l
0.14
52
303
434
3977
1.71
3.94
5.1
4.3
5.90
5.84
mmol/l
0.47
408
3612
149
1107
1.49
3.90
2.7
2.8
762.77
1075.11
ng/l
1.34
125
931
325
2803
1.46
3.86
3.7
3.7
—
—
—
0
0
7
8
8.85
3.78
1.3
1.8
1.70
1.90
umol/l
—
7
8
83
548
1.62
3.67
1.4
1.3
705.26
499.83
titre
0.32
19
119
13
35
3.79
3.61
1.3
1.2
—
—
—
0
0
35
180
2.02
3.53
1.9
1.3
—
—
—
0
0
149
1127
1.46
3.52
2.7
2.9
0.18
0.52
e6/l
2.82
101
836
203
1627
1.42
3.50
3.1
3.6
6.40
6.00
ph
—
10
113
36
189
1.98
3.44
23.7
6.5
24.93
24.44
mmol/l
0.40
36
184
62
386
1.69
3.44
1.5
1.4
—
—
—
0
0
251
2092
1.40
3.43
5.0
5.5
10.43
10.24
umol/l
0.16
237
1976
31
154
2.08
3.43
1.1
1.1
—
—
—
0
0
83
558
1.58
3.40
1.3
1.2
—
—
—
0
0
459
4313
1.82
3.27
11.4
9.8
24.45
24.14
u/l
0.17
446
4150
132
991
1.45
3.21
2.0
2.1
2.70
3.05
mg/l
1.18
111
845
324
2839
1.40
3.20
4.9
4.5
—
—
—
0
0
17
67
2.59
3.16
4.6
2.6
—
—
—
0
0
406
3713
1.51
3.14
6.0
5.3
38.75
39.17
mmol/mol
0.49
385
3440
60
382
1.65
3.07
3.7
3.4
—
—
—
0
0
457
4301
1.76
3.06
18.7
14.8
74.82
71.72
umol/l
0.84
457
4301
126
947
1.44
3.03
2.2
2.3
2647.29
8380.99
umol/l
1.30
101
837
5
5
10.08
2.98
1.2
1.2
—
—
—
0
0
102
738
1.48
2.98
1.4
1.3
16.03
9.99
u/ml
0.28
39
273
24
115
2.14
2.93
2.3
2.1
9.77
10.88
nmol/l
0.24
24
106
432
4018
1.57
2.93
4.5
4.2
4.72
4.78
mmol/l
0.61
408
3712
53
332
1.67
2.89
1.2
1.1
—
—
—
0
0
12
38
3.21
2.87
1.3
1.3
—
—
—
0
0
153
1204
1.39
2.82
2.4
2.1
129.59
177.45
u/l
1.32
143
1144
299
2616
1.36
2.80
3.6
2.9
48.77
43.62
u/l
0.46
284
2434
42
250
1.74
2.76
1.3
1.3
—
—
—
0
0
153
1209
1.38
2.74
3.0
2.3
57.99
59.95
u/l
0.13
144
1117
73
501
1.54
2.74
1.4
2.2
129.88
112.63
ug/g
0.16
53
379
46
282
1.70
2.72
20.6
5.9
—
—
—
0
0
9
24
3.80
2.68
1.1
1.3
2.04
1.98
mmol/l
—
9
24
22
106
2.13
2.67
1.2
1.2
—
154.00
—
0
5
24
120
2.05
2.65
2.2
2.7
—
—
—
0
0
378
3448
1.40
2.63
20.5
16.8
331.86
331.10
g/l
1.02
373
3420
429
4006
1.51
2.61
4.4
4.1
1.51
1.56
mmol/l
1.65
398
3689
7
15
4.72
2.60
1.4
1.3
205.57
157.51
mmol/24h
—
7
15
32
179
1.84
2.58
1.5
1.3
23.53
28.54
iu/l
0.39
26
159
118
905
1.40
2.50
1.8
1.6
1.07
1.02
mg/l
0.08
83
703
437
4105
1.53
2.49
5.2
4.7
2.77
2.81
mmol/l
0.41
408
3774
74
521
1.49
2.47
1.2
1.3
—
—
—
0
0
102
769
1.41
2.38
1.4
1.3
18.25
32.72
iu/ml
1.21
28
245
105
802
1.39
2.27
1.4
1.5
1.98
2.31
g/l
1.63
61
469
157
1282
1.33
2.21
3.2
2.9
27.18
29.49
u/l
1.09
148
1221
120
941
1.36
2.21
1.4
1.2
0.78
2.17
u/ml
1.43
23
244
13
54
2.45
2.21
1.2
1.2
—
—
—
0
0
31
182
1.75
2.17
17.0
6.7
—
—
—
0
0
471
4525
1.75
2.17
25.0
18.9
39.45
39.40
%
0.05
445
4219
10
36
2.81
2.15
2.4
3.5
—
—
—
0
0
10
36
2.81
2.15
1.3
2.0
—
—
—
0
0
60
417
1.50
2.15
16.3
5.8
4.96
5.16
kpa
0.78
55
401
60
417
1.50
2.15
16.2
5.8
13.24
12.42
kpa
0.54
55
401
235
2035
1.29
2.14
3.8
3.8
0.00
0.00
estimate
-0.00
41
415
471
4527
1.75
2.14
24.3
18.9
256.51
256.10
e9/l
0.05
462
4405
137
1103
1.33
2.12
2.8
2.8
—
—
—
0
0
471
4528
1.74
2.12
24.4
19.0
6.56
6.59
e9/l
0.14
460
4387
471
4529
1.74
2.10
24.3
18.9
4.46
4.42
e12/l
0.82
461
4391
8
25
3.23
2.10
2.1
3.7
—
—
—
0
0
106
826
1.36
2.03
3.0
2.8
544.49
521.25
mosm/kgh2o
0.44
94
699
9
32
2.84
2.01
1.2
1.3
—
—
—
0
0
59
418
1.47
1.93
16.5
5.8
1.31
1.41
mmol/l
0.06
48
335
17
85
2.04
1.92
1.2
1.3
—
—
—
0
0
13
58
2.27
1.92
1.4
1.3
0.46
0.63
nmol/l
1.42
13
52
132
1073
1.31
1.89
1.5
1.4
—
—
—
0
0
121
973
1.32
1.87
3.1
3.7
—
—
—
0
0
76
571
1.39
1.82
1.8
1.5
—
—
—
0
0
65
476
1.42
1.80
1.4
1.3
—
—
—
0
0
15
74
2.06
1.76
1.7
2.2
—
—
—
0
0
5
13
3.87
1.72
1.0
1.0
—
—
—
0
0
5
13
3.87
1.72
1.0
1.0
—
—
—
0
0
16
82
1.98
1.71
2.3
3.1
4.69
4.69
e9/l
0.00
16
82
234
2066
1.25
1.70
3.9
3.8
0.00
0.02
estimate
0.80
37
381
54
387
1.44
1.69
1.8
1.4
—
—
—
0
0
163
1381
1.27
1.68
3.2
3.1
—
—
—
0
0
44
303
1.50
1.68
1.3
1.4
—
—
—
0
0
13
62
2.13
1.67
1.5
1.9
—
—
—
0
0
6
19
3.18
1.66
2.2
3.7
—
—
—
0
0
207
1806
1.25
1.66
10.0
8.8
0.00
0.00
e9/l
0.75
162
1479
7
25
2.82
1.65
1.3
1.6
13.57
10.08
%
—
7
25
16
84
1.93
1.61
2.3
3.4
61.06
59.18
%
0.27
16
84
14
70
2.03
1.60
1.5
1.7
—
—
—
0
0
444
4252
1.41
1.59
14.0
11.9
—
—
—
0
0
11
50
2.23
1.58
1.3
1.3
—
—
nmol/l
—
0
0
55
403
1.41
1.54
2.1
2.1
1.68
1.79
%
0.47
45
348
17
93
1.86
1.53
1.4
1.3
393.82
518.97
mg/l
1.31
17
87
230
2046
1.23
1.51
5.6
5.2
0.00
0.00
estimate
0.50
38
389
5
16
3.15
1.44
1.4
1.4
110.00
56.94
nmol/24h
—
5
16
9
39
2.33
1.43
1.7
2.1
—
—
—
0
0
203
1790
1.23
1.43
15.6
12.4
1.43
1.19
inr
1.75
54
513
114
943
1.27
1.42
1.5
1.5
21.01
21.88
nmol/l
0.26
100
795
136
1150
1.25
1.41
4.3
3.6
—
—
—
0
0
133
1122
1.25
1.40
1.8
1.6
1.26
1.35
mmol/l
0.90
119
958
5
17
2.96
1.36
4.6
2.8
38800.00
38558.82
ug/l
—
5
17
66
512
1.33
1.32
3.2
2.1
20.01
22.72
%
0.91
57
442
117
981
1.25
1.30
4.4
3.7
—
—
—
0
0
5
18
2.79
1.29
1.4
1.6
115.80
160.44
nmol/l
—
5
18
11
55
2.02
1.28
1.8
1.7
—
—
—
0
0
17
100
1.72
1.25
1.4
1.3
—
—
—
0
0
15
85
1.79
1.24
1.3
1.2
3.39
3.76
mmol/l
1.07
15
78
8
38
2.12
1.19
1.3
1.6
—
—
—
0
0
11
57
1.95
1.18
1.5
1.2
—
—
—
0
0
11
57
1.95
1.18
1.7
1.8
68.00
58.19
%
0.97
11
57
49
371
1.36
1.17
1.4
1.4
—
—
—
0
0
0
34
0.00
1.16
0.0
1.1
—
—
—
0
0
13
72
1.83
1.16
4.2
2.9
—
—
—
0
0
403
3849
1.25
1.14
4.1
3.7
1.25
1.24
mmol/l
0.17
371
3509
69
552
1.29
1.13
3.1
2.0
2.45
2.37
g/l
0.45
64
503
82
673
1.26
1.10
2.0
1.8
—
—
—
0
0
7
32
2.20
1.08
2.4
2.7
—
—
—
0
0
15
90
1.69
1.05
3.3
3.1
15.90
26.92
mg/l
—
9
54
7
34
2.07
1.03
1.9
1.1
—
—
—
0
0
20
131
1.55
1.01
1.3
1.3
271.44
254.90
miu/ml
0.08
11
70
99
839
1.22
1.00
1.7
1.7
505.33
17698283.73
pmol/l
0.78
84
695
7
35
2.01
1.00
1.0
1.1
—
—
—
0
0
5
23
2.19
0.98
1.2
2.6
—
—
—
0
0
5
23
2.19
0.98
2.0
1.4
1.84
1.63
g/l
—
5
23
5
23
2.19
0.98
1.2
1.2
—
—
—
0
0
15
92
1.65
0.98
1.4
1.5
—
—
—
0
0
0
29
0.00
0.98
0.0
3.0
—
20.92
—
0
19
25
174
1.46
0.97
1.6
2.0
—
—
—
0
0
7
37
1.90
0.94
1.6
1.2
211.57
388.81
nmol/l
—
7
31
12
70
1.73
0.93
1.3
1.5
—
—
—
0
0
9
52
1.74
0.93
2.0
2.7
—
—
—
0
0
10
55
1.83
0.92
2.5
1.5
—
—
—
0
0
6
28
2.16
0.92
1.3
1.3
—
—
—
0
0
14
88
1.61
0.85
1.4
1.4
—
—
—
0
0
14
88
1.61
0.85
1.4
1.4
—
—
—
0
0
124
1094
1.18
0.83
3.9
3.5
—
—
—
0
0
16
105
1.54
0.82
1.8
1.5
—
—
—
0
0
24
172
1.42
0.82
1.1
1.2
—
—
—
0
0
99
857
1.19
0.82
2.6
2.4
5.64
5.88
e6/l
0.07
87
767
6
32
1.89
0.82
1.0
1.1
—
—
—
0
0
36
277
1.32
0.81
3.8
2.9
—
—
—
0
0
52
421
1.26
0.81
1.8
1.5
—
—
—
0
0
8
47
1.71
0.81
1.0
1.0
—
—
—
0
0
43
340
1.29
0.80
4.0
2.8
1.59
2.01
mmol/l
0.35
38
274
95
1089
0.84
0.78
4.6
4.0
0.00
0.00
estimate
0.50
36
381
25
185
1.37
0.73
2.9
2.2
1.20
1.17
%
0.04
25
185
9
56
1.62
0.72
1.4
1.3
—
—
—
0
0
100
877
1.18
0.72
3.9
4.1
1.02
1.02
kg/l
0.13
25
128
22
160
1.39
0.71
3.7
2.6
24.22
24.19
mmol/l
0.01
22
155
13
85
1.54
0.69
1.8
2.2
114.57
127.27
g/l
—
7
60
12
77
1.57
0.69
1.1
1.7
—
—
—
0
0
9
59
1.53
0.68
1.0
1.1
—
19.18
—
0
5
53
441
1.23
0.67
3.2
3.8
56.98
18.85
ug/l
0.31
44
365
5
28
1.79
0.66
2.0
1.6
0.93
1.04
g/l
—
5
28
8
49
1.64
0.62
2.8
1.4
31.63
31.59
pg
—
8
49
16
113
1.43
0.62
1.8
1.5
—
—
—
0
0
36
290
1.26
0.61
2.7
2.1
70.18
72.59
e9/l
0.18
28
210
8
51
1.58
0.60
1.0
1.0
—
—
—
0
0
63
541
1.19
0.59
2.0
1.8
—
—
—
0
0
16
114
1.42
0.59
1.8
1.5
—
—
—
0
0
16
114
1.42
0.59
1.8
1.5
—
—
—
0
0
15
106
1.43
0.58
1.1
1.2
—
—
—
0
0
45
375
1.22
0.58
1.7
1.6
—
—
—
0
0
125
1367
0.89
0.55
2.6
2.8
—
—
—
0
0
9
60
1.51
0.54
1.3
1.2
—
—
—
0
0
6
38
1.59
0.54
2.0
1.2
—
—
—
0
0
9
135
0.66
0.52
2.9
4.5
1.00
1.35
mmol/l
—
9
130
18
135
1.35
0.51
3.6
3.1
0.37
0.15
g/l
—
10
44
36
298
1.22
0.50
1.3
1.2
—
—
—
0
0
13
93
1.41
0.48
1.8
1.5
—
—
—
0
0
50
430
1.18
0.48
1.2
1.3
—
—
—
0
0
26
209
1.26
0.47
3.4
3.1
5.20
5.20
kpa
0.00
26
201
10
68
1.48
0.47
1.9
1.7
—
—
—
0
0
52
451
1.17
0.46
1.7
1.7
—
—
—
0
0
27
219
1.25
0.46
2.6
2.3
—
—
—
0
0
33
274
1.22
0.46
1.3
2.3
—
—
—
0
0
14
103
1.37
0.45
2.1
2.8
—
—
—
0
0
15
112
1.35
0.45
1.9
1.5
—
—
—
0
0
41
349
1.19
0.45
1.2
1.4
—
—
—
0
0
126
1164
1.11
0.44
3.4
2.8
7.80
6.90
mmol/l
1.25
112
988
28
338
0.82
0.43
1.5
1.3
—
—
—
0
0
5
32
1.57
0.42
1.0
1.1
—
—
—
0
0
8
57
1.41
0.42
3.6
2.5
—
—
—
0
0
8
58
1.39
0.41
3.6
2.4
105.13
106.55
mmol/l
—
8
58
8
58
1.39
0.41
3.6
2.4
4.09
3.94
mmol/l
—
8
58
5
33
1.52
0.41
1.2
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
1.74
—
0
5
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
15
114
1.33
0.41
1.6
1.3
252.12
313.51
ug/g
—
8
63
15
114
1.33
0.41
4.5
5.4
—
—
—
0
0
0
17
0.00
0.40
0.0
1.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
154
1446
1.09
0.39
3.9
3.5
37.18
61.06
ng/l
0.40
107
983
5
36
1.39
0.38
1.4
1.3
—
—
—
0
0
117
1087
1.10
0.37
3.4
2.9
69.67
103.21
mg/l
0.18
78
663
9
69
1.31
0.37
2.1
2.5
—
—
—
0
0
12
90
1.34
0.36
3.0
2.8
24.41
25.90
mmol/l
0.43
12
90
19
153
1.25
0.36
1.9
2.3
4037.98
3037.68
u/l
—
9
65
18
145
1.25
0.34
3.8
3.1
—
—
—
0
0
15
120
1.26
0.30
3.7
3.3
24.43
24.80
mmol/l
0.33
15
113
8
62
1.29
0.28
1.8
1.2
—
—
—
0
0
26
300
0.86
0.27
4.8
4.1
0.00
0.20
%
—
7
69
28
244
1.16
0.26
4.2
4.2
—
—
—
0
0
26
226
1.16
0.25
1.2
1.2
—
—
—
0
0
24
208
1.16
0.24
3.8
4.2
—
—
—
0
0
7
91
0.77
0.22
1.1
4.1
—
—
—
0
0
5
42
1.19
0.21
1.0
1.5
89.42
89.82
%
—
5
42
0
10
0.00
0.21
0.0
1.1
—
0.52
—
0
5
0
10
0.00
0.21
0.0
2.9
—
55.55
—
0
10
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
3.2
—
—
—
0
0
12
98
1.23
0.21
1.3
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
15
127
1.19
0.20
12.7
7.7
—
—
—
0
0
20
175
1.15
0.19
1.2
1.1
—
—
—
0
0
31
281
1.11
0.18
3.6
3.1
0.59
0.73
ug/l
0.61
21
195
31
340
0.91
0.17
5.8
3.8
—
—
—
0
0
10
82
1.22
0.17
2.3
1.6
—
—
—
0
0
8
73
1.10
0.15
1.1
1.2
—
—
—
0
0
119
1149
1.05
0.14
4.1
3.5
12.83
7.64
mg/mmol
0.26
75
685
14
122
1.15
0.14
2.1
1.5
142.14
234.52
ug/l
0.84
14
109
10
85
1.18
0.12
2.9
2.6
9.36
7.87
kpa
—
10
85
28
302
0.92
0.12
5.6
3.9
0.45
0.71
%
0.40
11
80
52
495
1.06
0.11
6.2
4.9
9.08
2.77
ug/l
0.43
47
429
29
311
0.93
0.11
3.4
3.4
—
—
—
0
0
34
320
1.07
0.10
4.6
3.9
0.33
0.16
%
0.28
12
86
5
48
1.04
0.09
2.0
2.3
—
—
—
0
0
16
146
1.10
0.08
1.1
1.1
—
—
—
0
0
7
66
1.06
0.08
5.7
3.2
46.00
34.56
umol/l
—
7
59
11
98
1.13
0.07
4.2
2.6
7.80
7.31
mmol/l
0.29
11
98
35
335
1.05
0.06
4.9
3.9
1.15
0.84
%
0.14
13
102
17
158
1.08
0.06
1.2
1.6
—
5.88
—
0
5
13
139
0.93
0.03
5.5
4.7
—
—
—
0
0
11
103
1.07
0.02
4.2
2.6
1.64
1.47
mmol/l
0.30
11
103
22
227
0.97
0.01
1.4
1.5
—
—
—
0
0
15
155
0.97
0.00
1.7
1.6
—
—
—
0
0
16
157
1.02
0.00
1.1
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
6.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
62
0.97
-0.00
2.0
1.7
—
—
—
0
0
6
65
0.92
-0.00
1.3
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
1.78
—
0
6
6
59
1.02
-0.00
4.3
3.8
41.67
71.15
u/ml
—
6
59
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
3.55
—
0
6
5
55
0.91
-0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
5.30
—
0
5
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_THYROIDNASOTH and mortality.

Females

Parameter HR [95% CI] p-value
E4_THYROIDNASOTH 1.444 [1.16, 1.8] 0.001
Birth year 0.993 [0.98, 1.0] 0.115

During the follow-up period (1.1.1998 — 31.12.2019), 162 out of 1145 females with E4_THYROIDNASOTH died.

Males

Parameter HR [95% CI] p-value
E4_THYROIDNASOTH 0.919 [0.68, 1.25] 0.585
Birth year 0.988 [0.98, 1.0] 0.012

During the follow-up period (1.1.1998 — 31.12.2019), 66 out of 391 males with E4_THYROIDNASOTH died.

Mortality risk

Mortality risk for people of age

years, who have E4_THYROIDNASOTH.

N-year risk Females Males
1 0.15% 0.156%
5 0.893% 1.064%
10 2.105% 2.826%
15 3.935% 5.346%
20 6.989% 8.95%

Relationships between endpoints

↥

Index endpoint: E4_THYROIDNASOTH – Disorder of thyroid, unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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