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Disorder of thyroid, unspecified

DOID EFO Endpoint Browser PheWeb

E4_THYROIDNASOTH

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

461

4. Check minimum number of events

None

461

5. Include endpoints

None

461

6. Filter based on genotype QC (FinnGen only)

461

Control definitions (FinnGen only)

Control exclude
E4_THYROID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3547 2760 749
Only index persons 2885 2275 610
Unadjusted period prevalence (%)
Whole population 0.07 0.08 0.02
Only index persons 0.07 0.08 0.02
Median age at first event (years)
Whole population 47.04 46.23 49.67
Only index persons 43.39 42.46 46.83

-FinnGen-

Key figures

All Female Male
Number of individuals 461 379 82
Unadjusted period prevalence (%) 0.11 0.13 0.04
Median age at first event (years) 43.64 41.67 52.70

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
392
Matched controls
3921
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
2601.8
175.9
157
*
H03AA01
ATC
levothyroxine sodium; systemic
71.9
171.5
193
52
24599
ICD-8 Finland
Thyroiditis, Unspecified
+∞
139.0
125
*
104
Kela drug reimbursment
Thyroid insufficiency
1094.6
91.7
86
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
159.0
84.9
87
7
E07.89
ICD-10 Finland
Other specified disorders of thyroid
+∞
74.4
69
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
173.1
44.8
46
*
E03
ICD-10 Finland
Other hypothyroidism
179.6
32.2
33
*
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
65.8
31.6
36
6
E03.89
ICD-10 Finland
Other specified hypothyroidism
119.7
31.2
33
*
H03BB01
ATC
carbimazole; oral
289.8
27.1
27
*
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
289.8
27.1
27
*
BAA60
NOMESCO Finland
Total thyroidectomy
243.6
22.9
23
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
22.1
21
*
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
33.3
21.8
28
9
T86
ICPC
Hypothyroidism/myxoedema
39.6
21.0
26
7
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
+∞
21.0
20
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
17.8
17
*
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
+∞
15.7
15
*
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
51.8
12.9
15
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.4
12.7
38
76
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
22.1
12.1
17
8
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
18.5
10.8
16
9
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
112.9
10.5
11
*
E07.81
ICD-10 Finland
Pituitary thyroxin resistence
+∞
10.5
10
*
E07.82
ICD-10 Finland
Disorder of thyroid function caused by general disease state
+∞
10.5
10
*
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
+∞
10.5
10
*
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
10.5
10
*
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
16.6
10.4
16
10
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
33.5
10.4
13
*
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
+∞
9.4
9
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
8.4
8
*
2469X
ICD-9 Finland
Other disorders of thyroid, Unspecified disorder of thyroid
+∞
8.4
8
*
E07.8
ICD-10 Finland
Other specified disorders of thyroid
+∞
8.4
8
*
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
81.6
7.4
8
*
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
+∞
7.3
7
*
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
30.6
7.2
9
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
6.6
117
724
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
6.4
147
991
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
6.3
147
992
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
+∞
6.3
6
*
C73.92
ICD-10 Finland
Follicular carcinoma of the thyroid gland
+∞
6.3
6
*
E07.80
ICD-10 Finland
Pituitary thyroxin resistence
+∞
6.3
6
*
24210
ICD-8 Finland
Thyrotoxicosis with or without goitre, Toxic nodular goitre
+∞
6.3
6
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.8
6.2
122
777

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
101
115
10.97
84.47
4.0
1.5
4.7
4.4
pmol/l
0.84
96
101
45
45
10.97
40.43
2.2
1.2
2.6
0.7
iu/l
—
18
5
393
2870
3.50
21.85
7.6
2.6
15.7
14.4
pmol/l
10.28
374
2574
68
193
3.96
21.42
1.4
1.2
127.9
87.5
iu/ml
0.40
26
69
267
1810
2.13
13.92
8.2
5.5
1.2
1.2
mmol/l
0.19
234
1548
74
294
2.81
13.33
2.3
1.8
378.4
363.5
nmol/l
0.26
69
267
419
3467
3.29
13.29
8.8
3.5
1.9
1.9
mu/l
0.10
398
3140
238
1641
1.93
10.81
7.7
4.7
1.2
1.2
mmol/l
0.40
221
1488
355
2827
2.11
10.36
4.8
4.1
12.2
12.1
mm/h
0.04
336
2599
182
1168
1.92
10.08
2.1
2.1
—
—
—
0
0
171
1098
1.89
9.30
4.5
3.3
7.4
7.4
ph
0.37
31
204
191
1271
1.86
9.28
3.0
3.3
2.3
2.4
mmol/l
0.97
172
1107
240
1740
1.79
8.59
4.0
3.7
—
—
—
0
0
58
254
2.47
8.50
2.6
3.0
69.4
81.6
ng/l
0.75
50
224
207
1496
1.70
7.04
2.3
2.0
101.6
94.7
pmol/l
1.16
109
706
239
1797
1.69
6.99
5.7
5.6
29.6
28.3
%
0.98
223
1650
70
370
2.05
6.51
2.1
2.3
5.7
6.5
umol/l
0.31
61
316
232
1761
1.64
6.31
5.9
5.7
8.4
8.4
%
0.04
220
1631
173
1219
1.67
6.31
5.2
5.4
—
—
—
0
0
109
678
1.80
6.21
3.6
3.4
784.7
195.5
ng/l
0.38
72
503
223
1688
1.62
6.05
5.6
5.6
0.6
0.7
%
1.26
211
1549
229
1753
1.61
5.88
5.7
5.4
3.1
2.7
%
2.28
216
1603
230
1776
1.59
5.60
5.5
5.4
55.3
57.3
%
1.74
215
1642
107
684
1.73
5.49
1.8
1.6
1001.1
1205.1
nmol/l
1.24
90
500
341
2901
1.67
5.49
7.3
6.8
75.1
76.0
u/l
0.21
328
2706
204
1542
1.58
5.38
4.8
3.8
36.6
35.7
g/l
1.71
192
1426
209
1598
1.56
5.19
2.1
2.0
—
—
—
0
0
243
1928
1.55
5.08
5.5
5.8
0.2
0.2
e9/l
2.51
218
1686
302
2534
1.56
4.76
4.9
4.6
6.0
3697.1
e6/l
—
5
34
420
3843
2.04
4.70
19.6
14.3
139.5
139.7
mmol/l
1.00
411
3725
8
8
10.15
4.53
1.3
1.8
1.7
1.9
umol/l
—
8
8
420
3852
2.02
4.53
19.9
14.4
3.9
3.9
mmol/l
0.38
410
3724
231
1849
1.50
4.41
5.5
5.4
0.6
0.6
e9/l
0.41
205
1590
61
353
1.84
4.34
3.7
3.5
—
—
—
0
0
413
3778
1.89
4.31
15.9
12.7
20.2
22.9
mg/l
0.94
339
2929
25
103
2.51
4.21
2.7
3.5
—
—
—
0
0
231
1861
1.48
4.20
5.5
5.4
0.0
0.0
e9/l
0.29
205
1598
235
1900
1.48
4.19
5.6
5.4
2.0
1.9
e9/l
0.27
210
1669
256
2116
1.47
4.02
6.5
4.0
6.6
6.5
mmol/l
0.03
239
1963
402
3673
1.74
3.87
5.2
4.3
5.9
5.8
mmol/l
0.70
377
3333
101
703
1.56
3.61
3.4
2.8
2.4
2.5
mmol/l
0.57
86
612
17
63
2.76
3.53
4.6
2.7
—
—
—
0
0
205
1666
1.42
3.31
3.6
2.6
105.8
106.8
ug/l
0.02
189
1525
122
902
1.48
3.26
2.0
2.1
2.7
3.1
mg/l
1.38
102
763
33
172
1.99
3.23
1.9
1.3
—
—
—
0
0
127
952
1.46
3.16
6.0
6.5
—
—
—
0
0
11
34
3.29
3.07
1.4
1.3
—
—
—
0
0
55
344
1.68
3.03
1.5
1.5
—
—
—
0
0
254
2163
1.39
3.02
7.9
8.7
3.8
4.0
e9/l
0.80
226
1877
5
5
10.09
2.98
1.2
1.2
—
—
—
0
0
96
691
1.49
2.91
1.3
1.3
16.0
10.0
u/ml
0.28
39
251
143
1114
1.41
2.85
2.4
2.1
124.0
180.1
u/l
1.69
133
1060
23
110
2.15
2.83
2.3
2.7
—
—
—
0
0
117
880
1.44
2.83
2.2
2.4
2873.6
8652.0
umol/l
1.16
92
766
75
516
1.54
2.81
1.4
1.4
777.5
491.3
titre
0.40
16
113
375
3439
1.48
2.78
6.2
5.3
39.0
39.2
mmol/mol
0.12
355
3188
298
2625
1.38
2.77
5.0
4.5
—
—
—
0
0
168
1351
1.38
2.77
3.5
3.6
14.3
68.6
e6/l
6.08
109
922
398
3698
1.56
2.74
4.5
4.2
4.7
4.8
mmol/l
0.45
373
3413
74
511
1.53
2.72
1.3
1.2
—
—
—
0
0
421
3966
1.71
2.71
18.8
14.9
75.3
71.9
umol/l
0.87
421
3966
143
1123
1.40
2.70
3.1
2.2
58.9
57.1
u/l
0.12
134
1040
9
24
3.80
2.68
1.1
1.3
2.0
2.0
mmol/l
—
9
24
13
49
2.70
2.64
1.2
1.2
—
—
—
0
0
142
1119
1.39
2.62
3.0
3.1
41.5
133.0
e6/l
0.73
103
846
422
3986
1.69
2.58
11.4
9.9
24.4
24.1
u/l
0.11
410
3835
10
33
3.08
2.54
1.3
1.2
—
—
—
0
0
228
1947
1.34
2.48
5.2
5.4
10.4
10.2
umol/l
0.18
214
1836
30
167
1.85
2.47
17.5
7.2
—
—
—
0
0
49
315
1.62
2.45
1.2
1.1
—
—
—
0
0
68
472
1.52
2.45
1.5
2.1
156.7
109.6
ug/g
0.47
48
353
395
3686
1.50
2.42
4.4
4.2
1.5
1.6
mmol/l
1.55
366
3389
109
834
1.40
2.37
1.8
1.6
1.1
1.0
mg/l
0.10
77
645
134
1063
1.37
2.34
4.3
3.7
—
—
—
0
0
13
53
2.49
2.29
1.4
1.2
0.5
0.6
nmol/l
1.32
13
47
96
723
1.41
2.28
1.4
1.3
19.4
33.6
iu/ml
1.00
25
217
402
3780
1.50
2.21
5.1
4.7
2.7
2.8
mmol/l
0.49
376
3468
41
259
1.64
2.21
17.5
6.3
—
—
—
0
0
16
74
2.20
2.17
2.3
3.2
4.7
4.6
e9/l
0.04
16
74
290
2596
1.32
2.13
3.8
3.6
—
—
—
0
0
16
76
2.15
2.05
2.3
3.5
61.1
58.9
%
0.32
16
76
110
863
1.36
2.04
1.6
1.5
20.8
22.1
nmol/l
0.42
96
729
43
281
1.58
2.04
1.3
1.4
—
—
—
0
0
28
163
1.76
2.03
1.5
1.4
26.5
26.9
iu/l
0.02
22
143
56
389
1.50
2.03
13.3
5.9
5.0
5.1
kpa
0.60
51
376
56
389
1.50
2.03
13.3
5.9
12.9
12.5
kpa
0.24
51
376
19
98
1.98
1.98
1.3
1.2
—
154.0
—
0
5
98
759
1.37
1.97
1.8
1.7
499.4
19586430.5
pmol/l
0.78
83
628
38
243
1.61
1.97
2.1
2.5
4.3
4.0
e9/l
0.24
33
183
14
64
2.22
1.96
1.8
2.4
—
—
—
0
0
97
752
1.37
1.94
2.9
2.6
535.9
530.6
mosm/kgh2o
0.07
86
631
9
33
2.76
1.94
1.3
1.2
—
—
—
0
0
7
22
3.21
1.88
1.3
1.6
13.6
10.3
%
—
7
22
58
413
1.46
1.87
18.7
22.3
1.5
1.2
inr
0.69
13
54
11
46
2.43
1.86
1.3
1.3
—
—
nmol/l
—
0
0
434
4175
1.67
1.86
24.4
19.0
256.6
256.0
e9/l
0.07
427
4057
128
1042
1.32
1.85
2.8
3.0
0.2
0.4
e6/l
1.99
88
771
216
1883
1.28
1.84
3.9
3.8
0.0
0.0
estimate
0.00
32
354
434
4177
1.67
1.83
24.4
19.0
4.4
4.4
e12/l
0.64
426
4046
55
390
1.47
1.81
13.5
5.9
1.2
1.3
mmol/l
0.07
42
310
434
4178
1.66
1.81
24.5
19.0
6.6
6.6
e9/l
0.11
425
4044
54
382
1.47
1.80
2.2
2.2
1.7
1.8
%
0.44
44
328
66
487
1.41
1.77
1.2
1.3
—
—
—
0
0
8
30
2.70
1.73
1.3
1.3
—
—
—
0
0
11
48
2.32
1.71
1.8
1.6
—
—
—
0
0
364
3408
1.32
1.67
18.7
14.0
38.5
39.0
%
0.36
273
2432
342
3179
1.29
1.63
20.4
16.8
331.9
331.1
g/l
1.03
337
3153
8
32
2.53
1.60
1.3
1.6
—
—
—
0
0
108
876
1.30
1.59
1.4
1.2
0.8
2.3
u/ml
1.45
22
226
94
749
1.32
1.57
1.4
1.4
2.0
2.3
g/l
1.26
54
433
13
64
2.06
1.55
4.2
2.7
—
—
—
0
0
35
237
1.52
1.47
1.2
1.3
—
—
—
0
0
5
16
3.15
1.44
4.8
2.6
—
—
—
0
0
5
16
3.15
1.44
1.4
1.6
115.8
160.7
nmol/l
—
5
16
47
340
1.43
1.43
1.4
1.4
—
—
—
0
0
409
3921
1.38
1.40
14.6
11.8
—
—
—
0
0
215
1918
1.23
1.38
4.1
3.8
0.0
0.0
estimate
0.50
36
347
15
82
1.86
1.37
1.2
1.3
—
—
—
0
0
119
996
1.26
1.36
1.5
1.4
—
—
—
0
0
147
1261
1.24
1.36
3.3
3.1
—
—
—
0
0
5
17
2.96
1.36
2.4
3.8
—
—
—
0
0
16
90
1.81
1.34
1.4
1.3
394.7
529.2
mg/l
1.38
16
84
13
68
1.94
1.34
1.5
1.2
—
—
—
0
0
6
24
2.52
1.30
2.5
3.8
—
—
—
0
0
8
35
2.31
1.27
3.0
3.8
—
—
—
0
0
373
3544
1.27
1.25
4.1
3.7
1.2
1.2
mmol/l
0.05
342
3231
8
36
2.24
1.25
1.7
1.2
—
—
—
0
0
6
25
2.42
1.24
1.7
1.4
—
—
—
0
0
15
85
1.79
1.24
3.3
3.2
15.9
24.7
mg/l
—
9
50
211
1895
1.21
1.23
5.7
5.3
0.0
0.0
estimate
0.50
36
357
22
141
1.59
1.19
1.1
1.1
—
—
—
0
0
16
94
1.73
1.19
1.8
1.5
—
—
—
0
0
108
909
1.25
1.18
3.2
3.8
—
—
—
0
0
10
50
2.02
1.17
1.4
1.3
—
—
—
0
0
5
20
2.52
1.15
2.0
1.5
—
—
—
0
0
10
51
1.98
1.12
1.8
1.7
69.1
58.5
%
—
10
51
5
21
2.40
1.09
2.4
3.3
—
—
—
0
0
7
33
2.14
1.06
1.6
1.2
211.6
386.7
nmol/l
—
7
27
7
33
2.14
1.06
1.0
1.1
—
—
—
0
0
42
317
1.36
1.04
16.7
6.4
120.0
119.3
g/l
0.09
37
310
66
532
1.28
1.04
1.8
1.5
—
—
—
0
0
185
1663
1.19
1.03
10.1
8.8
0.0
0.0
e9/l
0.75
151
1356
67
542
1.28
1.03
3.1
2.1
12.3
13.1
umol/l
0.48
62
490
14
83
1.71
1.02
1.3
1.2
3.4
3.8
mmol/l
1.05
14
76
105
895
1.22
1.02
4.4
3.7
—
—
—
0
0
12
68
1.79
1.01
1.1
1.8
—
—
—
0
0
41
310
1.35
1.01
4.1
3.0
1.5
1.9
mmol/l
0.30
35
242
7
35
2.02
1.00
1.9
1.2
—
—
—
0
0
56
446
1.29
0.97
1.4
1.3
—
—
—
0
0
19
125
1.54
0.95
3.6
3.2
0.4
0.1
g/l
—
10
40
0
32
0.00
0.95
0.0
1.2
—
—
—
0
0
16
101
1.61
0.94
1.8
1.4
—
—
—
0
0
52
412
1.30
0.94
3.2
3.8
58.5
19.1
ug/l
0.31
43
343
117
1017
1.20
0.94
3.0
2.9
—
—
—
0
0
16
102
1.59
0.91
1.8
1.4
—
—
—
0
0
16
102
1.59
0.91
1.8
1.4
—
—
—
0
0
116
1010
1.20
0.91
4.1
3.5
—
—
—
0
0
15
95
1.60
0.88
1.5
1.3
—
—
—
0
0
24
170
1.43
0.87
3.0
2.4
1.2
1.2
%
0.04
24
170
13
80
1.64
0.85
1.8
1.5
—
—
—
0
0
36
275
1.34
0.85
2.8
2.2
70.6
72.0
e9/l
0.10
28
199
6
31
1.95
0.84
2.5
2.7
—
—
—
0
0
8
45
1.79
0.84
2.8
1.4
31.6
31.6
pg
—
8
45
46
365
1.29
0.84
1.8
1.4
—
—
—
0
0
0
27
0.00
0.77
0.0
3.1
—
21.4
—
0
18
61
507
1.23
0.77
3.2
2.1
2.4
2.4
g/l
0.25
56
461
121
1074
1.17
0.76
3.5
2.9
7.7
6.9
mmol/l
1.19
108
901
6
34
1.77
0.76
2.0
1.2
—
—
—
0
0
11
67
1.66
0.75
1.3
1.4
—
—
—
0
0
57
472
1.24
0.75
3.5
2.1
19.7
22.8
%
1.28
48
405
5
24
2.09
0.74
1.2
1.4
—
2032.2
—
0
5
5
25
2.01
0.73
1.2
1.1
—
—
—
0
0
5
25
2.01
0.73
2.0
1.7
0.9
1.1
g/l
—
5
25
7
40
1.76
0.71
2.3
2.4
—
—
—
0
0
93
813
1.18
0.71
4.1
4.1
1.0
1.0
kg/l
0.22
25
115
17
118
1.46
0.70
1.1
1.3
332.9
262.9
miu/ml
—
8
61
13
85
1.54
0.69
1.4
1.5
—
—
—
0
0
73
626
1.20
0.69
1.9
1.8
—
—
—
0
0
9
59
1.54
0.68
1.6
1.9
—
—
—
0
0
5
27
1.86
0.68
1.4
1.3
—
—
—
0
0
22
162
1.38
0.67
1.1
1.2
—
—
—
0
0
7
43
1.64
0.67
1.3
1.2
—
—
—
0
0
12
78
1.55
0.66
1.9
2.0
114.6
127.1
g/l
—
7
52
15
103
1.47
0.65
1.9
1.4
—
—
—
0
0
156
1431
1.14
0.63
11.8
7.6
1.4
1.2
inr
0.87
37
410
19
139
1.38
0.61
3.6
3.0
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
26
202
1.30
0.58
2.8
2.3
—
—
—
0
0
59
505
1.19
0.58
2.0
1.8
—
—
—
0
0
112
1010
1.14
0.58
3.5
3.0
71.3
112.2
mg/l
0.21
76
610
114
1030
1.14
0.57
1.7
1.6
1.3
1.3
mmol/l
0.77
102
877
8
55
1.46
0.56
3.6
2.5
—
—
—
0
0
25
317
0.78
0.56
1.5
1.3
—
—
—
0
0
146
1343
1.13
0.56
4.1
3.5
37.9
62.4
ng/l
0.38
104
914
12
82
1.48
0.55
1.3
1.4
—
—
—
0
0
12
82
1.48
0.55
1.3
1.4
—
—
—
0
0
89
795
1.15
0.53
2.7
2.4
5.7
5.8
e6/l
0.05
77
696
9
62
1.46
0.53
2.1
2.4
—
—
—
0
0
16
117
1.38
0.53
3.6
3.1
24.3
24.7
mmol/l
0.46
16
110
18
135
1.35
0.52
1.9
2.3
4038.0
3343.2
u/l
—
9
57
46
390
1.20
0.51
1.7
1.5
—
—
—
0
0
21
162
1.31
0.51
1.7
1.9
—
—
—
0
0
15
110
1.38
0.49
4.5
5.0
—
—
—
0
0
13
93
1.41
0.48
1.1
1.2
—
—
—
0
0
28
227
1.25
0.48
4.2
4.4
—
—
—
0
0
92
831
1.13
0.47
4.4
4.5
—
—
—
0
0
10
68
1.48
0.47
2.3
1.6
—
—
—
0
0
92
1014
0.88
0.47
4.7
4.0
0.0
0.0
estimate
0.50
34
348
41
350
1.19
0.44
1.7
1.6
—
—
—
0
0
48
416
1.17
0.43
1.7
1.8
—
—
—
0
0
31
258
1.22
0.43
4.2
2.8
—
—
—
0
0
8
56
1.44
0.42
3.6
2.4
4.1
3.9
mmol/l
—
8
56
8
56
1.44
0.42
3.6
2.4
105.1
106.7
mmol/l
—
8
56
5
33
1.52
0.41
3.0
2.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
33
278
1.20
0.41
1.3
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
5
35
1.43
0.39
1.0
1.5
89.4
89.7
%
—
5
35
9
66
1.37
0.38
1.9
1.7
—
—
—
0
0
5
36
1.39
0.38
1.4
1.3
—
—
—
0
0
14
107
1.32
0.37
1.6
1.3
252.1
303.9
ug/g
—
8
60
6
43
1.40
0.35
1.3
1.4
—
—
—
0
0
6
43
1.40
0.35
1.3
1.4
—
—
—
0
0
6
43
1.40
0.35
1.3
1.4
—
—
—
0
0
6
43
1.40
0.35
1.3
1.4
—
—
—
0
0
30
258
1.17
0.32
1.3
2.3
—
—
—
0
0
114
1069
1.09
0.31
4.4
3.7
13.2
7.9
mg/mmol
0.26
73
640
7
53
1.33
0.31
1.4
1.1
—
—
—
0
0
7
55
1.28
0.30
1.4
1.3
—
—
—
0
0
117
1242
0.92
0.30
2.7
2.8
—
—
—
0
0
25
213
1.18
0.29
1.1
1.2
—
—
—
0
0
15
121
1.25
0.29
12.7
7.8
—
—
—
0
0
44
398
1.12
0.25
1.2
1.3
—
—
—
0
0
6
81
0.74
0.24
1.0
4.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.7
—
56.3
—
0
11
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
1.7
—
0
5
33
299
1.11
0.19
4.8
4.0
0.4
0.2
%
0.27
11
78
49
454
1.09
0.19
6.0
4.9
9.7
2.8
ug/l
0.44
44
392
11
91
1.21
0.17
4.2
2.7
7.8
7.3
mmol/l
0.33
11
91
25
278
0.89
0.17
5.0
4.2
0.0
0.2
%
—
6
61
34
314
1.09
0.14
5.0
4.0
1.2
0.9
%
0.16
12
85
13
149
0.87
0.13
1.8
1.6
—
—
—
0
0
11
95
1.16
0.11
4.2
2.6
1.6
1.5
mmol/l
0.29
11
95
27
291
0.92
0.11
3.6
3.4
—
—
—
0
0
5
44
1.14
0.10
1.0
1.0
—
—
—
0
0
5
44
1.14
0.10
2.0
2.4
—
—
—
0
0
5
45
1.11
0.10
1.0
1.0
—
1.0
—
0
15
21
195
1.08
0.08
4.2
4.1
—
—
—
0
0
28
264
1.06
0.08
3.6
3.0
0.6
0.7
ug/l
0.52
18
183
7
81
0.86
0.07
2.0
2.3
—
—
—
0
0
34
324
1.05
0.07
1.2
1.4
—
—
—
0
0
27
282
0.95
0.04
5.8
4.0
0.3
0.6
%
—
7
57
14
149
0.94
0.03
1.1
1.3
—
—
—
0
0
10
92
1.09
0.03
1.2
1.1
—
—
—
0
0
22
212
1.04
0.02
5.7
6.8
23.8
24.9
mmol/l
0.33
16
201
12
115
1.04
0.00
2.3
1.5
96.3
231.4
ug/l
2.05
12
104
17
165
1.03
0.00
1.1
1.1
—
—
—
0
0
31
308
1.01
0.00
5.8
3.9
—
—
—
0
0
13
129
1.01
0.00
5.5
5.0
—
—
—
0
0
20
199
1.01
0.00
1.4
1.5
—
—
—
0
0
5
58
0.86
0.00
2.0
1.6
—
—
—
0
0
6
68
0.88
0.00
1.2
1.1
—
—
—
0
0
14
140
1.00
0.00
1.1
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
6
63
0.95
0.00
1.3
1.2
—
—
—
0
0
6
59
1.02
0.00
2.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
6
60
1.00
0.00
4.8
3.5
42.8
33.7
umol/l
—
6
51
0
7
0.00
0.00
0.0
7.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
3.5
—
0
6
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
15
150
1.00
0.00
1.1
1.6
—
5.9
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
49
1.02
0.00
1.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
5.8
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
1.8
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_THYROIDNASOTH and mortality.

Females

Parameter HR [95% CI] p-value
E4_THYROIDNASOTH 1.444 [1.16, 1.8] 0.001
Birth year 0.993 [0.98, 1.0] 0.115

During the follow-up period (1.1.1998 — 31.12.2019), 162 out of 1145 females with E4_THYROIDNASOTH died.

Males

Parameter HR [95% CI] p-value
E4_THYROIDNASOTH 0.919 [0.68, 1.25] 0.585
Birth year 0.988 [0.98, 1.0] 0.012

During the follow-up period (1.1.1998 — 31.12.2019), 66 out of 391 males with E4_THYROIDNASOTH died.

Mortality risk

Mortality risk for people of age

years, who have E4_THYROIDNASOTH.

N-year risk Females Males
1 0.15% 0.156%
5 0.893% 1.064%
10 2.105% 2.826%
15 3.935% 5.346%
20 6.989% 8.95%

Relationships between endpoints

↥

Index endpoint: E4_THYROIDNASOTH – Disorder of thyroid, unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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