lens disease: A disease involving the lens of camera-type eye. [database_cross_reference: MONDO:DesignPattern]
Other specified and unspecified disorders of lens
DOID EFO Endpoint Browser PheWeb
H7_DISORDERLENSNAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
322 |
4. Check minimum number of eventsNone |
322 |
5. Include endpointsNone |
322 |
6. Filter based on genotype QC (FinnGen only) |
308 |
Control definitions (FinnGen only)
- Control exclude
- H7_LENS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other specified and unspecified disorders of lens
based on the number of shared cases.
Similar with more cases:
- Disorders of lens
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2266 | 1677 | 581 |
| Only index persons | 2126 | 1584 | 542 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.02 |
| Only index persons | 0.05 | 0.06 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 76.62 | 76.97 | 75.56 |
| Only index persons | 76.59 | 76.93 | 75.59 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 308 | 212 | 96 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.04 |
| Median age at first event (years) | 74.17 | 73.73 | 75.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 322
- Matched controls
- 3220
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
374.6
307.7
256
33
H27.8
ICD-10 Finland
Other specified disorders of lens
13809.3
307.7
312
*
H25.1
ICD-10 Finland
Senile nuclear cataract
62.3
288.7
181
65
Z96.1
ICD-10 Finland
Presence of intraocular lens
34.7
202.9
148
77
WX100
NOMESCO Finland
Conjunctival surface anesthesia
72.7
186.5
104
21
H25.8
ICD-10 Finland
Other senile cataract
321.6
140.2
133
7
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
34.7
107.4
71
26
H40.0
ICD-10 Finland
Glaucoma suspect
11.2
81.7
104
132
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
7.6
73.7
202
586
H26.4
ICD-10 Finland
After-cataract
222.5
70.2
70
*
S01ED51
ATC
timolol, combinations; ophthalmic
10.8
68.9
86
105
CJB10
NOMESCO Finland
Laser discission of secondary cataract
109.3
58.3
62
7
H25.0
ICD-10 Finland
Senile incipient cataract
14.1
41.7
40
32
114
Kela drug reimbursment
Glaucoma
6.4
41.7
82
163
WX140
NOMESCO Finland
Parabulbar anesthesy
11.9
38.3
41
39
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
8.6
34.9
48
64
S01EE01
ATC
latanoprost; ophthalmic
6.3
31.0
58
108
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
11.7
27.3
29
27
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
4.3
24.3
76
218
H04.10
ICD-10 Finland
Dry eye syndrome
4.7
21.9
57
141
S01EC04
ATC
brinzolamide; ophthalmic
7.2
21.3
33
50
CHD00
NOMESCO Finland
Laser trabeculoplasty
24.4
20.8
29
13
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.0
20.7
197
1102
XCH00
NOMESCO Finland
Eye pressure measurement
8.3
19.8
27
35
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
6.4
19.6
34
58
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
5.5
19.3
40
81
CKD60
NOMESCO Finland
Anterior vitrectomy
190.0
17.7
18
*
SPAT1263
SPAT
Sampling
2.7
17.4
172
954
CS494
NOMESCO Finland
Other visual field testing
13.7
17.0
29
23
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
4.5
16.7
44
109
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.3
16.4
46
120
WX110
NOMESCO Finland
Infiltration anesthesia
2.7
15.9
220
1419
S01EA05
ATC
brimonidine; ophthalmic
12.7
15.4
27
23
XCK00
NOMESCO Finland
Perimetry
4.6
14.8
37
88
SPAT1312
SPAT
General health counselling
2.6
14.3
124
631
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
14.1
191
1191
S01ED01
ATC
timolol; ophthalmic
5.8
13.8
26
48
Z03.8
ICD-10 Finland
Observation for other suspected diseases and conditions
4.6
13.3
33
78
CHC05
NOMESCO Finland
Iridotomy
20.1
13.1
19
10
AA1AD
NOMESCO Finland
CT of head and brain
2.4
12.8
130
705
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
72.8
12.7
14
*
S01EE05
ATC
tafluprost; ophthalmic
5.2
12.6
27
56
H53.1
ICD-10 Finland
Subjective visual disturbances
4.3
12.3
33
83
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.4
11.6
106
545
H27.1
ICD-10 Finland
Dislocation of lens
+∞
11.5
11
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.3
11.4
132
750
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
3.7
10.9
37
110
DAX08
NOMESCO Finland
Fitting of hearing aid
3.6
10.5
36
108
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.3
10.4
100
522
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
24.3
10.3
14
6
A98
ICPC
Health maint/preventive medicine
3.8
10.3
298
2463
WX720
NOMESCO Finland
Own respiration
4.7
10.2
24
54
SPAT1325
SPAT
Vaccination
2.1
10.1
148
915
SPAT1310
SPAT
Counselling related to known health issue
2.2
10.0
121
693
H52.2
ICD-10 Finland
Astigmatism
12.7
10.0
17
14
NG2AA
NOMESCO Finland
Patella X-ray examination
5.2
9.9
21
43
S01EC01
ATC
acetazolamide; systemic
11.1
9.9
18
17
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.1
9.8
156
990
E0000UV, ,
ATC
2.1
9.6
142
875
Z97.2
ICD-10 Finland
Presence of dental prosthetic device (complete)(partial)
4.7
9.5
22
49
N06AX26
ATC
vortioxetine; oral
5.1
9.4
20
41
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.6
9.4
61
264
XCW10
NOMESCO Finland
Assessment of vision
22.5
9.4
13
6
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
5.0
9.2
20
42
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.6
9.1
61
268
SPAT1211
SPAT
Application of soft bandage
3.0
9.1
43
157
NF1AA
NOMESCO Finland
Hip X-ray examination
2.7
9.1
53
217
UKC02
NOMESCO Finland
Cystoscopy
2.4
9.0
70
331
S01EC03
ATC
dorzolamide; ophthalmic
14.6
8.8
14
10
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.4
8.6
69
330
JN3AD
NOMESCO Finland
Abdominal CT examination
2.8
8.5
47
187
CHD35
NOMESCO Finland
Laser goniopuncture
28.4
8.5
11
*
L15
ICPC
Knee symptom/complaint
2.2
8.5
93
506
SPAT1153
SPAT
Removal of sutures
2.1
8.4
121
730
SPAT1360
SPAT
Extensive global examination
3.1
8.4
36
124
SPAT1053
SPAT
Memory test
2.2
8.3
89
480
WX002
NOMESCO Finland
Sedation and analgesia
2.3
8.3
74
370
SAA03
NOMESCO Finland
Extended examination of mouth
2.1
8.2
105
607
Z75.1
ICD-10 Finland
Person awaiting admission to adequate facility elsewhere
7.6
8.1
18
25
-45
ICPC
Observ/health educat/advice/diet
4.8
8.0
18
39
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.0
8.0
149
983
S01EC54
ATC
brinzolamide, combinations; ophthalmic
13.5
7.9
13
10
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.9
7.9
40
152
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
46.1
7.7
9
*
D07AB02
ATC
hydrocortisone butyrate; topical
2.1
7.7
97
554
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
7.0
7.7
18
27
H52.1
ICD-10 Finland
Myopia
10.4
7.6
14
14
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.3
7.6
66
326
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
2.0
7.5
97
560
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.9
7.5
158
1079
SPAT1172
SPAT
Guidance concerning hydration
4.2
7.5
20
50
D06BB10
ATC
imiquimod; topical
3.4
7.4
27
84
WZA90
NOMESCO Finland
Other medical or dental certificate
2.2
7.4
72
372
SPAT1254
SPAT
Administration of medicine
2.2
7.4
71
365
H52.0
ICD-10 Finland
Hypermetropia
9.7
7.4
14
15
H27.9
ICD-10 Finland
Disorder of lens, unspecified
+∞
7.3
7
*
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
2.8
7.3
37
141
S01EE04
ATC
travoprost; ophthalmic
6.3
7.2
18
30
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.6
7.0
44
187
DFF00
NOMESCO Finland
Pure tone audiometry
2.4
6.9
50
227
L57.0
ICD-10 Finland
Actinic keratosis
2.2
6.8
63
318
SPAT1097
SPAT
Recording of ECG
2.2
6.7
68
356
P20
ICPC
Memory disturbance
2.0
6.7
84
477
S01EA03
ATC
apraclonidine; ophthalmic
23.1
6.7
9
*
WX725
NOMESCO Finland
Noninvasive ventilation
3.6
6.7
22
64
SAA01
NOMESCO Finland
Simple examination of mouth
1.8
6.7
186
1370
F16
ICPC
Eyelid symptom/complaint
3.6
6.5
22
65
C10AA07
ATC
rosuvastatin; oral
1.9
6.5
104
641
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
3.9
6.5
19
51
S18
ICPC
Laceration/cut
1.8
6.4
151
1052
M01AX05
ATC
glucosamine; oral
1.9
6.4
100
613
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
3.3
6.3
24
77
F29
ICPC
Eye symptom/complaint other
2.7
6.3
36
146
WX144
NOMESCO Finland
Subconjunctival anesthesy
+∞
6.3
6
*
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
+∞
6.3
6
*
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
3.7
6.3
20
57
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.6
6.3
21
62
L17
ICPC
Foot/toe symptom/complaint
1.9
6.2
100
617
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.6
6.2
36
147
R02
ICPC
Shortness of breath/dyspnoea
2.3
6.2
53
259
L90
ICPC
Osteoarthrosis of knee
2.7
6.2
35
141
WX704
NOMESCO Finland
Intubation
3.0
6.2
28
100
CBB30
NOMESCO Finland
Excision of lesion of eyelid
4.3
6.2
16
39
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.8
6.1
141
974
J01MA12
ATC
levofloxacin; systemic
2.0
6.0
72
401
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
128
288
6.72
58.87
5.3
4.8
36.88
35.01
%
0.72
64
163
221
1208
3.64
26.43
2.7
2.1
114.78
94.51
pmol/l
3.33
104
558
143
625
3.32
24.19
1.8
1.8
849.77
1160.69
nmol/l
5.51
99
451
216
1277
3.10
20.44
5.5
5.5
1.22
1.22
mmol/l
0.63
169
1157
211
1244
3.02
19.83
3.8
2.8
46.53
50.61
u/l
0.25
179
1120
48
122
4.45
17.72
2.2
2.0
—
—
—
0
0
46
114
4.54
17.52
2.2
1.8
—
—
—
0
0
290
2163
4.43
16.44
6.3
5.1
2.09
2.06
mu/l
0.11
232
1932
298
2266
5.23
16.43
6.6
5.0
5.99
6.08
mmol/l
0.65
240
2011
298
2266
5.23
16.43
6.2
5.3
2.39
2.59
mmol/l
3.63
238
2023
257
1782
3.19
16.40
5.1
4.0
14.99
15.94
mm/h
0.39
215
1617
220
1409
2.77
16.26
7.0
6.1
1.23
1.22
mmol/l
1.12
175
1202
291
2188
4.43
16.01
5.4
4.6
4.43
4.52
mmol/l
0.70
236
1961
287
2179
3.92
14.62
5.9
4.6
1.62
1.52
mmol/l
2.80
228
1945
307
2446
6.48
14.55
13.5
10.6
21.59
22.58
u/l
0.98
279
2338
279
2106
3.43
13.82
4.8
4.0
1.14
1.24
mmol/l
2.57
216
1854
285
2179
3.68
13.82
8.0
6.4
40.98
40.84
mmol/mol
0.08
229
1974
222
1499
2.55
13.55
5.7
4.7
6.83
6.78
mmol/l
0.13
215
1399
262
1919
2.96
13.52
8.4
7.1
78.11
80.39
u/l
0.35
231
1777
136
740
2.45
13.42
2.6
2.2
55.36
60.13
u/l
0.43
118
677
143
801
2.41
13.17
2.2
2.0
121.64
311.06
u/l
1.27
132
741
169
1023
2.37
12.99
4.8
4.1
32.73
135.06
ng/l
0.93
138
784
77
324
2.81
12.82
5.2
7.3
—
—
—
0
0
202
1326
2.40
12.82
20.2
17.4
1.19
1.40
inr
1.68
22
358
306
2491
5.60
12.69
26.0
19.8
139.27
139.50
mmol/l
0.63
294
2429
306
2493
5.58
12.63
26.2
20.0
3.99
3.99
mmol/l
0.05
294
2428
129
703
2.39
12.50
1.9
1.6
19.94
20.93
nmol/l
0.25
92
584
308
2532
5.98
12.32
31.9
24.2
246.61
246.52
e9/l
0.01
301
2447
308
2533
5.97
12.29
31.9
24.2
4.26
4.32
e12/l
1.37
300
2440
308
2533
5.97
12.29
31.9
24.4
37.13
38.57
%
1.83
264
2325
308
2533
5.97
12.29
32.1
24.4
128.65
129.97
g/l
0.86
302
2479
177
1115
2.30
12.12
5.8
5.3
59.77
58.92
%
0.40
150
1030
127
698
2.35
11.97
2.4
2.1
3.00
3.26
mg/l
0.42
99
574
293
2346
3.76
11.76
20.7
16.6
22.55
29.07
mg/l
2.68
258
1909
200
1338
2.31
11.71
6.2
5.6
10.97
11.73
umol/l
0.77
183
1266
177
1131
2.25
11.51
6.2
5.4
25.36
25.94
%
0.31
152
1043
166
1046
2.21
11.03
2.6
2.2
83.92
82.16
nmol/l
0.27
121
896
151
919
2.21
10.91
3.0
2.7
135.05
140.44
ug/l
0.12
126
817
239
1773
2.35
10.27
4.5
4.2
15.24
15.39
pmol/l
0.38
184
1581
117
655
2.24
10.26
2.5
2.3
—
—
—
0
0
97
503
2.33
10.20
2.4
1.7
—
—
—
0
0
21
42
5.28
10.19
2.8
2.4
28.33
36.09
mg/l
—
6
11
159
1013
2.13
9.96
2.7
2.2
—
—
—
0
0
42
147
3.14
9.59
2.2
4.3
2.09
2.29
mmol/l
0.10
35
115
147
935
2.05
9.00
3.6
3.1
2270.52
1967.46
ng/l
0.22
109
816
27
78
3.69
8.29
3.6
2.8
—
—
—
0
0
127
817
1.92
7.12
4.0
3.7
3.56
10.59
mg/mmol
2.41
61
497
165
1166
1.85
6.82
3.0
2.5
—
—
—
0
0
99
598
1.95
6.62
1.5
1.8
531.93
433.17
pmol/l
1.99
72
476
16
30
5.55
5.92
1.4
1.5
—
—
—
0
0
16
30
5.55
5.92
1.4
1.5
—
—
—
0
0
17
46
3.85
5.72
1.4
1.8
—
—
—
0
0
57
302
2.08
5.42
6.3
2.9
346.71
226.12
ng/l
0.44
52
281
184
1402
1.73
5.42
8.5
8.2
4.38
4.22
e9/l
0.35
153
1192
19
58
3.42
5.39
1.8
1.5
—
—
—
0
0
58
310
2.06
5.39
4.2
4.0
255.60
266.15
u/l
0.16
48
293
16
44
3.77
5.27
1.4
1.8
—
—
—
0
0
259
2191
1.93
5.22
18.2
16.5
66.99
69.89
ml/min/173m2
1.36
205
1779
43
208
2.23
5.13
1.5
1.6
—
—
—
0
0
44
215
2.21
5.13
2.0
1.6
—
—
—
0
0
14
28
5.18
5.00
2.0
2.1
—
—
—
0
0
12
21
5.89
4.80
1.3
1.7
—
—
—
0
0
12
21
5.89
4.80
1.3
1.7
—
—
—
0
0
17
55
3.21
4.43
1.5
1.5
—
—
—
0
0
136
1001
1.62
4.24
2.5
3.2
2.35
2.37
mmol/l
0.58
89
850
87
585
1.67
3.82
3.2
2.8
329.48
11756.35
umol/l
4.27
61
490
10
20
5.12
3.72
1.6
1.4
—
—
—
0
0
10
20
5.12
3.72
1.6
1.4
—
—
—
0
0
81
545
1.65
3.52
7.3
5.6
8.25
2.90
ug/l
0.67
71
468
78
520
1.66
3.51
1.6
1.6
1.11
1.38
mg/l
0.74
63
406
84
582
1.60
3.23
6.8
3.9
601.53
249.66
ng/l
0.27
72
511
6
8
7.61
3.06
1.0
1.9
—
—
—
0
0
6
8
7.61
3.06
1.0
1.9
—
—
—
0
0
84
589
1.58
3.05
1.8
1.6
1.02
1.28
mmol/l
3.86
70
492
96
696
1.54
3.01
3.7
2.6
26.74
32.48
u/l
2.42
90
660
6
9
6.77
2.88
1.0
1.8
—
—
—
0
0
152
1222
1.46
2.85
5.4
4.0
34.35
34.41
g/l
0.05
135
1113
40
638
0.57
2.77
6.6
4.6
0.00
0.00
estimate
-0.00
14
225
5
6
8.44
2.76
2.0
2.8
19.38
18.33
nmol/l
—
5
6
7
14
5.08
2.74
1.1
1.0
—
—
—
0
0
6
10
6.09
2.71
1.0
1.8
—
—
—
0
0
6
10
6.09
2.71
1.0
1.8
—
—
—
0
0
19
86
2.29
2.69
2.0
2.1
217.46
1032.08
ug/l
0.89
19
81
42
263
1.69
2.39
2.6
3.1
133.07
82.77
ng/l
0.68
30
223
9
28
3.28
2.32
1.3
1.8
—
—
—
0
0
7
18
3.95
2.26
1.0
1.7
—
—
—
0
0
7
18
3.95
2.26
1.0
1.7
—
—
—
0
0
7
18
3.95
2.26
1.0
1.7
—
—
—
0
0
10
35
2.92
2.23
1.1
1.9
—
—
—
0
0
62
437
1.52
2.17
6.1
4.7
22.16
20.81
%
0.26
30
234
6
14
4.35
2.16
1.0
1.0
—
—
—
0
0
10
36
2.83
2.15
1.7
1.5
—
—
—
0
0
10
37
2.76
2.09
1.7
1.5
—
—
—
0
0
10
37
2.76
2.09
1.7
1.5
—
—
—
0
0
5
10
5.06
2.08
2.2
1.1
251.60
119.80
nmol/l
—
5
10
58
795
0.67
2.03
4.6
3.3
0.47
0.64
e6/l
0.32
49
594
8
26
3.13
2.02
1.3
1.2
—
—
—
0
0
8
26
3.13
2.02
1.3
1.2
—
—
—
0
0
8
26
3.13
2.02
1.4
1.9
—
—
—
0
0
52
360
1.53
1.98
4.1
4.5
1.01
1.05
mmol/l
0.52
46
323
5
11
4.60
1.95
1.2
1.2
—
—
—
0
0
18
93
1.99
1.89
1.0
1.0
—
—
—
0
0
7
22
3.23
1.89
1.6
1.2
—
—
—
0
0
7
22
3.23
1.89
1.4
2.0
—
—
—
0
0
8
28
2.90
1.87
1.4
1.9
—
—
—
0
0
6
17
3.58
1.84
1.2
1.2
—
—
—
0
0
43
291
1.55
1.82
1.7
1.3
—
—
—
0
0
37
242
1.60
1.80
1.2
1.3
—
—
—
0
0
18
95
1.95
1.79
2.2
4.1
—
1.49
—
0
8
25
148
1.75
1.76
2.5
1.8
1.72
1.74
g/l
0.03
19
129
8
30
2.71
1.73
1.3
1.8
—
—
—
0
0
7
24
2.96
1.73
1.3
1.3
—
236.46
miu/ml
—
0
7
5
13
3.89
1.72
1.0
1.0
—
—
—
0
0
5
13
3.89
1.72
1.0
1.0
—
—
—
0
0
66
495
1.42
1.69
5.3
4.5
1.02
1.02
kg/l
0.01
14
71
6
20
3.04
1.59
1.0
1.9
—
—
—
0
0
14
71
2.02
1.56
1.2
1.4
—
—
—
0
0
45
319
1.48
1.55
5.7
6.7
1.55
1.19
mmol/l
0.45
37
259
9
37
2.47
1.49
1.8
1.5
—
—
—
0
0
9
37
2.47
1.49
1.8
1.5
—
—
—
0
0
9
37
2.47
1.49
1.8
1.5
—
—
—
0
0
7
28
2.53
1.46
2.1
1.8
—
—
—
0
0
6
22
2.76
1.44
1.2
1.9
—
—
—
0
0
17
97
1.79
1.38
1.2
1.2
—
—
—
0
0
5
18
2.80
1.29
1.4
1.3
—
—
—
0
0
5
18
2.80
1.29
1.4
1.3
—
—
—
0
0
54
411
1.38
1.28
3.0
2.4
2.39
2.28
g/l
0.54
44
375
6
25
2.43
1.25
1.3
2.1
—
—
—
0
0
5
19
2.66
1.22
1.4
1.3
—
—
—
0
0
55
424
1.36
1.21
3.2
2.8
0.81
0.81
mmol/l
0.11
41
386
50
644
0.74
1.20
2.9
3.0
2.48
2.48
mmol/l
0.01
43
561
8
39
2.08
1.16
1.4
1.4
—
—
—
0
0
5
21
2.40
1.09
1.0
1.1
—
—
—
0
0
5
21
2.40
1.09
1.4
1.0
—
—
—
0
0
56
446
1.31
1.01
3.0
2.4
11.17
11.91
umol/l
0.30
48
406
7
35
2.02
1.00
1.6
1.5
—
—
—
0
0
43
334
1.33
0.92
1.1
1.3
32.25
49.52
iu/ml
0.50
15
120
45
354
1.32
0.89
2.6
1.6
—
—
—
0
0
8
42
1.93
0.89
1.1
1.1
—
—
—
0
0
48
385
1.29
0.83
3.0
2.5
19.47
20.96
%
0.28
31
331
85
980
0.82
0.83
4.4
3.2
—
—
—
0
0
16
235
0.66
0.82
5.4
3.8
1.23
1.23
mmol/l
0.03
16
201
13
81
1.63
0.82
1.2
1.2
—
—
—
0
0
41
325
1.30
0.78
1.1
1.2
61.86
22.52
u/ml
—
5
87
11
67
1.66
0.76
2.1
1.9
123.83
127.12
g/l
—
6
43
31
238
1.33
0.74
2.2
2.3
18.23
7.47
ug/l
0.45
15
195
5
25
2.02
0.73
1.0
1.1
—
—
—
0
0
41
503
0.79
0.71
3.3
2.9
0.62
1.54
e6/l
2.76
21
275
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
14
93
1.53
0.70
1.9
2.0
0.34
0.37
u/ml
—
8
52
21
281
0.73
0.67
3.8
3.7
—
—
—
0
0
12
78
1.56
0.66
1.8
1.8
—
—
—
0
0
5
28
1.80
0.66
1.0
1.1
—
—
—
0
0
52
437
1.23
0.63
1.5
1.9
28.72
29.67
s
0.74
47
422
11
163
0.66
0.61
3.3
3.1
61.80
56.22
ml/min/173m2
—
5
77
8
51
1.58
0.61
1.6
1.2
128.13
490.75
pmol/l
—
8
51
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
43
357
1.24
0.59
2.7
1.6
—
—
—
0
0
10
149
0.66
0.58
11.9
9.9
94.97
94.55
%
—
10
149
8
54
1.49
0.57
1.0
1.8
—
—
—
0
0
40
479
0.81
0.57
3.2
2.9
2.08
3.82
e6/l
1.02
20
253
18
133
1.37
0.56
1.7
2.8
10.24
9.84
g/l
0.17
12
120
6
37
1.63
0.56
1.5
1.2
—
—
—
0
0
6
38
1.59
0.54
1.2
1.2
—
—
—
0
0
16
119
1.36
0.49
2.0
2.0
1.46
1.58
%
0.35
11
99
130
1206
1.13
0.48
4.9
4.2
0.00
0.00
estimate
-0.00
15
266
18
140
1.30
0.43
1.7
2.8
6.52
7.70
g/l
2.25
12
128
18
140
1.30
0.43
1.7
2.7
3.57
3.47
g/l
0.10
12
128
18
140
1.30
0.43
1.7
2.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.9
—
—
—
0
0
10
71
1.42
0.39
1.2
1.1
—
—
—
0
0
9
68
1.33
0.38
2.8
2.2
—
—
—
0
0
9
71
1.28
0.36
1.2
1.1
—
—
—
0
0
6
41
1.47
0.36
1.2
1.1
—
—
—
0
0
6
41
1.47
0.36
1.3
1.2
—
—
—
0
0
6
42
1.44
0.35
4.2
3.6
35.00
56.82
u/ml
—
6
42
37
322
1.17
0.34
4.4
3.2
0.99
0.87
ug/l
0.34
28
229
16
129
1.25
0.31
1.8
2.9
2.65
3.18
g/l
—
10
117
15
121
1.25
0.29
1.9
2.9
0.00
0.67
g/l
—
8
106
22
186
1.20
0.28
1.2
1.5
—
—
—
0
0
8
63
1.28
0.28
2.5
2.0
—
—
—
0
0
19
159
1.21
0.27
3.7
2.8
26.36
25.33
mmol/l
0.66
19
154
8
67
1.20
0.26
1.1
1.1
—
—
—
0
0
8
67
1.20
0.26
1.1
1.1
—
—
—
0
0
128
1223
1.08
0.24
5.1
4.1
0.00
0.00
estimate
-0.00
14
238
14
115
1.23
0.24
1.9
2.6
38.74
36.47
g/l
—
8
102
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
2.7
—
—
—
0
0
0
13
0.00
0.21
0.0
2.7
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
7
61
1.15
0.17
1.3
1.4
—
—
—
0
0
5
66
0.75
0.17
1.0
1.3
—
—
—
0
0
8
99
0.80
0.14
2.5
2.9
0.00
0.00
g/l
—
8
91
32
342
0.93
0.11
5.5
6.3
103.13
103.25
mmol/l
0.06
32
342
6
54
1.11
0.09
1.8
2.4
77.50
88.22
%
—
6
54
16
147
1.09
0.07
2.8
2.1
1.07
1.05
%
0.05
16
147
88
895
0.98
0.04
5.5
4.5
—
—
—
0
0
29
301
0.96
0.04
3.8
3.0
2.71
2.09
mmol/l
0.65
24
242
123
1216
1.02
0.03
7.6
5.5
0.00
0.00
estimate
-0.00
14
237
15
143
1.05
0.01
2.9
2.1
0.65
0.62
%
0.17
15
143
27
273
0.99
0.00
3.0
2.6
65.17
65.63
g/l
0.13
21
248
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
5
0.00
-0.00
0.0
8.4
—
127.20
—
0
5
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
3.90
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
18.2
—
5.40
—
0
5
5
56
0.89
-0.00
3.2
2.5
103.60
105.11
mmol/l
—
5
56
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
113.17
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
8.62
—
0
5
5
55
0.91
-0.00
1.4
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_DISORDERLENSNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_DISORDERLENSNAS | 0.822 [0.71, 0.95] | 0.008 |
| Birth year | 0.991 [0.98, 1.0] | 0.045 |
During the follow-up period (1.1.1998 — 31.12.2019), 396 out of 1446 females with H7_DISORDERLENSNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_DISORDERLENSNAS | 0.896 [0.71, 1.13] | 0.349 |
| Birth year | 0.987 [0.98, 1.0] | 0.038 |
During the follow-up period (1.1.1998 — 31.12.2019), 167 out of 496 males with H7_DISORDERLENSNAS died.
Mortality risk
Mortality risk for people of age
years, who have H7_DISORDERLENSNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.07% | 0.164% |
| 5 | 0.401% | 1.067% |
| 10 | 1.029% | 2.606% |
| 15 | 1.935% | 5.137% |
| 20 | 3.429% | 8.56% |
Relationships between endpoints
↥Index endpoint: H7_DISORDERLENSNAS – Other specified and unspecified disorders of lens
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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