lens disease: A disease involving the lens of camera-type eye. [database_cross_reference: MONDO:DesignPattern]
Other specified and unspecified disorders of lens
DOID EFO Endpoint Browser PheWeb
H7_DISORDERLENSNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
309 |
4. Check minimum number of eventsNone |
309 |
5. Include endpointsNone |
309 |
6. Filter based on genotype QC (FinnGen only) |
309 |
Control definitions (FinnGen only)
- Control exclude
- H7_LENS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other specified and unspecified disorders of lens
based on the number of shared cases.
Similar with more cases:
- Disorders of lens
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2266 | 1677 | 581 |
| Only index persons | 2126 | 1584 | 542 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.02 |
| Only index persons | 0.05 | 0.06 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 76.62 | 76.97 | 75.56 |
| Only index persons | 76.59 | 76.93 | 75.59 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 309 | 216 | 93 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.04 |
| Median age at first event (years) | 73.94 | 73.68 | 74.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 276
- Matched controls
- 2758
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H27.8
ICD-10 Finland
Other specified disorders of lens
10310.7
323.0
266
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
364.6
244.4
220
29
H25.1
ICD-10 Finland
Senile nuclear cataract
116.3
142.9
148
27
H25.8
ICD-10 Finland
Other senile cataract
311.9
117.8
112
6
Z96.1
ICD-10 Finland
Presence of intraocular lens
35.7
87.5
115
54
WX100
NOMESCO Finland
Conjunctival surface anesthesia
50.9
62.9
75
20
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
9.1
61.7
182
482
H26.4
ICD-10 Finland
After-cataract
144.6
46.4
48
*
H40.0
ICD-10 Finland
Glaucoma suspect
10.9
40.8
84
106
CJB10
NOMESCO Finland
Laser discission of secondary cataract
61.6
36.6
42
8
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
19.8
31.6
48
29
S01ED51
ATC
timolol, combinations; ophthalmic
7.5
22.5
56
91
H25.0
ICD-10 Finland
Senile incipient cataract
12.8
19.1
34
30
114
Kela drug reimbursment
Glaucoma
5.3
17.6
58
133
CHD00
NOMESCO Finland
Laser trabeculoplasty
22.8
17.6
25
12
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
17.8
16.9
26
16
WX140
NOMESCO Finland
Parabulbar anesthesy
12.3
15.1
27
24
CKD60
NOMESCO Finland
Anterior vitrectomy
+∞
14.7
14
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.7
14.3
157
899
S01EE01
ATC
latanoprost; ophthalmic
5.7
14.3
42
84
SPAT1263
SPAT
Sampling
2.7
14.0
146
809
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
6.2
13.9
38
69
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.0
13.8
39
74
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
13.2
157
927
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
6.4
12.2
32
55
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
3.6
12.1
60
200
SPAT1312
SPAT
General health counselling
2.6
11.6
109
552
H52.2
ICD-10 Finland
Astigmatism
36.7
11.4
14
*
H04.10
ICD-10 Finland
Dry eye syndrome
4.2
11.0
43
116
CHC05
NOMESCO Finland
Iridotomy
19.7
10.4
15
8
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.7
10.3
81
367
H27.1
ICD-10 Finland
Dislocation of lens
+∞
9.4
9
*
AA1AD
NOMESCO Finland
CT of head and brain
2.4
9.4
97
507
XCK00
NOMESCO Finland
Perimetry
4.6
9.4
32
76
WX110
NOMESCO Finland
Local anesthesy
2.2
9.3
175
1208
H52.0
ICD-10 Finland
Hypermetropia
20.8
8.5
12
6
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
8.3
8.5
18
23
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.4
8.5
80
395
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
4.9
8.5
27
60
Z03.8
ICD-10 Finland
Observation for other suspected diseases and conditions
4.6
8.1
27
63
WX002
NOMESCO Finland
Sedation and analgesia
2.5
7.9
66
305
E0000UV
ATC
NA
2.1
7.9
119
726
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.1
7.9
135
871
S01EC04
ATC
brinzolamide; ophthalmic
5.5
7.7
22
43
XCH00
NOMESCO Finland
Eye pressure measurement
8.7
7.4
15
18
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
6.6
7.4
18
29
H27.9
ICD-10 Finland
Disorder of lens, unspecified
+∞
7.3
7
*
H52.1
ICD-10 Finland
Myopia
12.5
7.1
12
10
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
7.1
132
867
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
3.2
7.0
35
118
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
8.6
6.9
14
17
SPAT1325
SPAT
Vaccination
2.0
6.8
128
839
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
41.1
6.8
8
*
NF1AA
NOMESCO Finland
Hip X-ray examination
2.8
6.6
44
177
WX720
NOMESCO Finland
Own respiration
4.9
6.6
20
43
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
71.4
6.5
7
*
P20
ICPC
Memory disturbance
2.3
6.4
64
322
WX320
NOMESCO Finland
Spinalanesthesy
2.1
6.4
77
421
H53.1
ICD-10 Finland
Subjective visual disturbances
3.9
6.4
25
69
SPAT1153
SPAT
Removal of sutures
2.0
6.3
107
669
SPAT1254
SPAT
Administration of medicine
2.3
6.3
61
303
SPAT1310
SPAT
Counselling related to known health issue
2.0
6.1
100
614
A98
ICPC
Health maint/preventive medicine
2.5
6.1
247
2136
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
122
273
6.73
56.44
5.3
4.7
37.1
34.5
%
1.04
59
157
216
1177
3.77
26.37
2.7
2.1
113.5
95.0
pmol/l
2.79
100
539
139
617
3.28
22.86
1.9
1.7
857.7
1177.6
nmol/l
5.57
96
451
205
1176
3.21
21.06
3.8
2.8
46.1
50.9
u/l
0.30
175
1058
208
1241
3.07
19.21
5.6
5.3
1.2
1.2
mmol/l
0.48
163
1118
46
110
4.74
18.37
2.2
2.0
—
—
—
0
0
44
103
4.82
18.02
2.2
1.8
—
—
—
0
0
247
1709
3.22
15.95
5.2
3.9
15.3
15.8
mm/h
0.18
208
1555
212
1364
2.77
15.49
7.0
6.0
1.2
1.2
mmol/l
0.96
168
1150
278
2083
4.34
15.42
6.4
5.1
2.1
2.0
mu/l
0.21
223
1869
285
2185
4.92
15.00
6.2
5.3
2.4
2.6
mmol/l
3.48
228
1958
285
2193
4.86
14.73
6.6
5.0
6.0
6.1
mmol/l
0.51
230
1952
278
2114
4.14
14.37
5.4
4.6
4.4
4.5
mmol/l
0.81
226
1903
133
704
2.56
14.25
2.6
2.2
54.7
55.1
u/l
0.07
115
642
215
1434
2.64
13.90
5.8
4.6
6.9
6.8
mmol/l
0.21
208
1336
164
969
2.48
13.72
4.9
3.9
33.2
79.1
ng/l
0.77
134
740
294
2352
6.15
13.56
13.6
10.4
21.6
22.4
u/l
0.71
269
2252
138
759
2.48
13.44
2.2
1.9
122.1
319.4
u/l
1.23
128
697
252
1842
3.00
13.20
8.4
6.9
78.4
80.4
u/l
0.27
224
1703
274
2102
3.68
13.13
5.9
4.6
1.6
1.5
mmol/l
2.36
218
1883
273
2109
3.53
12.51
8.1
6.4
41.1
40.7
mmol/mol
0.23
220
1921
267
2038
3.28
12.46
4.7
4.0
1.1
1.2
mmol/l
1.88
207
1800
126
686
2.41
12.32
1.9
1.6
20.0
21.4
nmol/l
0.38
91
572
125
680
2.41
12.23
2.4
2.1
3.0
3.2
mg/l
0.34
97
561
194
1280
2.39
12.10
6.2
5.5
10.9
11.6
umol/l
0.74
178
1205
74
316
2.76
11.97
5.3
7.3
—
—
—
0
0
293
2393
5.33
11.84
26.7
19.6
139.2
139.5
mmol/l
0.86
282
2334
293
2395
5.31
11.78
26.8
19.7
4.0
4.0
mmol/l
0.04
282
2332
295
2433
5.69
11.50
32.5
23.8
247.5
246.1
e9/l
0.12
288
2351
295
2434
5.68
11.47
32.8
23.9
128.4
130.0
g/l
1.14
289
2382
295
2434
5.68
11.47
32.5
23.8
4.3
4.3
e12/l
1.56
287
2344
41
127
3.57
11.42
2.2
4.5
2.1
2.1
mmol/l
0.02
35
97
147
886
2.26
11.05
3.0
2.7
135.5
138.1
ug/l
0.05
123
787
281
2258
3.70
11.04
21.2
16.0
22.3
29.0
mg/l
2.69
249
1832
94
475
2.41
10.61
2.5
1.7
—
—
—
0
0
20
37
5.71
10.54
2.7
2.2
28.3
40.3
mg/l
—
6
9
251
1916
2.65
10.50
24.4
19.1
33.9
37.5
%
2.02
106
1185
231
1721
2.36
9.81
4.6
4.1
15.2
15.4
pmol/l
0.33
178
1537
111
625
2.21
9.57
2.5
2.2
—
—
—
0
0
159
1030
2.12
9.54
2.6
2.2
83.8
82.6
nmol/l
0.17
116
886
26
67
4.15
9.34
3.7
2.8
—
—
—
0
0
152
975
2.10
9.29
2.7
2.2
—
—
—
0
0
143
899
2.10
9.20
3.6
3.0
2328.8
1935.7
ng/l
0.29
106
780
14
23
6.33
8.25
2.0
2.2
—
—
—
0
0
122
777
1.94
7.13
4.0
3.9
3.7
10.2
mg/mmol
2.07
58
483
12
20
6.20
6.95
1.2
1.7
—
—
—
0
0
12
20
6.20
6.95
1.2
1.7
—
—
—
0
0
43
183
2.57
6.84
1.5
1.5
—
—
—
0
0
19
50
3.98
6.64
1.8
1.5
—
—
—
0
0
96
575
1.97
6.63
1.5
1.7
534.5
431.1
pmol/l
2.10
71
457
158
1121
1.84
6.42
4.2
3.7
—
—
—
0
0
178
1332
1.79
5.87
8.6
7.9
4.4
4.2
e9/l
0.58
148
1126
57
294
2.15
5.85
6.3
2.9
346.7
232.7
ng/l
0.41
52
274
16
41
4.06
5.79
1.4
1.6
—
—
—
0
0
15
39
3.99
5.33
1.5
1.6
—
—
—
0
0
56
298
2.07
5.28
4.3
3.9
256.6
266.4
u/l
0.15
47
281
42
202
2.25
5.10
2.1
1.6
—
—
—
0
0
247
2108
1.86
4.56
18.2
16.3
66.6
69.5
ml/min/173m2
1.27
195
1721
85
549
1.76
4.41
3.2
2.8
333.6
12924.6
umol/l
4.27
59
450
16
52
3.19
4.14
1.5
1.4
—
—
—
0
0
132
972
1.63
4.14
2.5
3.2
2.4
2.4
mmol/l
0.33
83
822
76
494
1.71
3.81
1.6
1.6
1.1
1.3
mg/l
0.46
61
387
95
660
1.63
3.69
3.7
2.5
26.8
32.6
u/l
2.27
89
623
19
75
2.63
3.53
2.0
2.2
217.5
1173.8
ug/l
0.92
19
70
76
506
1.67
3.46
7.1
5.7
8.4
3.0
ug/l
0.64
67
433
6
7
8.71
3.27
1.0
2.0
—
—
—
0
0
6
7
8.71
3.27
1.0
2.0
—
—
—
0
0
6
8
7.62
3.07
1.0
1.9
—
—
—
0
0
5
5
10.13
2.99
2.0
3.0
19.4
18.8
nmol/l
—
5
5
10
30
3.41
2.93
1.7
1.6
—
—
—
0
0
6
9
6.77
2.88
1.0
1.9
—
—
—
0
0
6
9
6.77
2.88
1.0
1.9
—
—
—
0
0
6
9
6.77
2.88
1.0
1.9
—
—
—
0
0
6
9
6.77
2.88
1.0
1.9
—
—
—
0
0
10
31
3.30
2.79
1.7
1.6
—
—
—
0
0
10
31
3.30
2.79
1.7
1.6
—
—
—
0
0
81
575
1.55
2.79
7.0
3.9
609.9
248.6
ng/l
0.28
71
500
147
1181
1.47
2.79
5.5
4.0
34.3
34.5
g/l
0.16
132
1080
7
14
5.09
2.74
1.1
1.0
—
—
—
0
0
39
617
0.58
2.63
6.8
4.5
0.0
0.0
estimate
0.00
14
214
7
15
4.75
2.61
1.0
1.9
—
—
—
0
0
7
15
4.75
2.61
1.0
1.9
—
—
—
0
0
7
15
4.75
2.61
1.0
1.9
—
—
—
0
0
5
7
7.24
2.56
2.2
1.0
251.6
146.6
nmol/l
—
5
7
8
21
3.88
2.48
1.4
1.7
—
—
—
0
0
6
12
5.07
2.41
1.2
1.2
—
—
—
0
0
80
584
1.50
2.40
1.8
1.6
1.0
1.3
mmol/l
3.37
67
486
6
13
4.68
2.28
1.0
1.0
—
—
—
0
0
8
24
3.39
2.19
1.4
1.6
—
—
—
0
0
8
24
3.39
2.19
1.3
1.3
—
—
—
0
0
8
24
3.39
2.19
1.3
1.3
—
—
—
0
0
7
19
3.74
2.16
1.4
1.7
—
—
—
0
0
66
473
1.50
2.15
5.3
4.6
1.0
1.0
kg/l
0.11
14
61
40
255
1.65
2.14
2.4
3.1
134.1
83.0
ng/l
0.66
29
216
9
31
2.96
2.09
1.8
1.6
—
—
—
0
0
9
31
2.96
2.09
1.8
1.6
—
—
—
0
0
9
31
2.96
2.09
1.8
1.6
—
—
—
0
0
56
775
0.66
2.09
4.8
3.3
0.5
0.7
e6/l
0.25
46
571
58
408
1.52
2.06
6.1
4.8
22.2
21.1
%
0.20
27
218
18
90
2.06
2.05
2.2
4.4
—
3.3
—
0
8
9
32
2.87
2.01
1.1
1.7
—
—
—
0
0
45
303
1.57
1.95
5.7
6.5
1.3
1.4
mmol/l
0.05
36
244
50
345
1.54
1.94
4.1
4.5
1.0
1.1
mmol/l
0.42
45
312
35
223
1.64
1.89
1.2
1.3
—
—
—
0
0
8
28
2.91
1.87
1.3
1.7
—
—
—
0
0
5
12
4.22
1.83
1.2
1.2
—
—
—
0
0
7
23
3.09
1.81
2.1
1.9
—
—
—
0
0
24
140
1.77
1.78
2.5
1.8
1.8
1.7
g/l
0.05
18
121
7
24
2.96
1.73
1.3
1.3
—
236.5
miu/ml
—
0
7
5
13
3.89
1.72
1.0
1.0
—
—
—
0
0
5
13
3.89
1.72
1.0
1.0
—
—
—
0
0
5
13
3.89
1.72
1.4
1.0
—
—
—
0
0
54
390
1.47
1.70
3.0
2.4
2.4
2.3
g/l
0.64
44
353
17
90
1.94
1.68
1.0
1.0
—
—
—
0
0
14
69
2.08
1.67
1.2
1.3
—
—
—
0
0
17
91
1.92
1.64
1.2
1.2
—
—
—
0
0
41
282
1.52
1.63
1.7
1.3
—
—
—
0
0
7
26
2.73
1.59
1.4
1.5
—
—
—
0
0
6
20
3.04
1.59
1.0
2.0
—
—
—
0
0
47
635
0.69
1.51
3.0
2.9
2.5
2.5
mmol/l
0.11
40
556
54
401
1.42
1.48
3.3
2.7
0.8
0.8
mmol/l
0.15
40
363
5
16
3.16
1.44
1.4
1.4
—
—
—
0
0
5
16
3.16
1.44
1.4
1.4
—
—
—
0
0
6
22
2.76
1.44
1.7
1.2
—
—
—
0
0
43
309
1.45
1.40
1.1
1.2
32.2
39.6
iu/ml
0.19
15
104
56
424
1.39
1.38
3.0
2.4
11.2
12.0
umol/l
0.32
48
383
41
296
1.44
1.31
1.1
1.2
61.9
17.1
u/ml
—
5
76
5
19
2.66
1.22
1.4
1.3
—
—
—
0
0
5
19
2.66
1.22
1.0
1.2
—
—
—
0
0
6
26
2.33
1.19
1.3
2.0
—
—
—
0
0
5
20
2.52
1.15
1.2
1.5
—
—
—
0
0
7
30
2.36
1.13
1.6
1.3
—
—
—
0
0
5
21
2.40
1.09
1.0
1.1
—
—
—
0
0
48
371
1.35
1.06
3.0
2.5
19.5
21.1
%
0.32
31
318
44
341
1.34
0.96
2.6
1.6
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
14
85
1.68
0.96
1.9
2.0
0.3
0.4
u/ml
—
8
45
7
37
1.91
0.94
1.3
1.5
—
—
—
0
0
166
1804
0.83
0.89
29.3
20.7
14.0
13.9
%
0.43
161
1762
31
232
1.37
0.85
2.2
2.1
18.2
6.9
ug/l
0.48
15
191
6
31
1.95
0.85
1.5
1.1
—
—
—
0
0
82
948
0.82
0.83
4.5
3.2
—
—
—
0
0
13
81
1.63
0.82
1.2
1.2
—
—
—
0
0
40
498
0.77
0.77
3.4
2.9
0.6
1.6
e6/l
2.71
20
266
6
34
1.78
0.76
1.2
1.1
—
—
—
0
0
6
34
1.78
0.76
1.2
1.1
—
—
—
0
0
128
1153
1.19
0.76
4.9
4.0
0.0
0.0
estimate
0.00
14
230
7
40
1.77
0.71
1.1
1.2
—
—
—
0
0
42
341
1.27
0.68
2.8
1.6
—
—
—
0
0
18
128
1.43
0.67
1.7
2.6
10.5
10.0
g/l
—
10
109
16
223
0.70
0.65
5.4
3.8
1.2
1.2
mmol/l
0.02
16
192
5
29
1.74
0.64
1.0
1.1
—
—
—
0
0
11
71
1.57
0.63
1.9
1.7
—
—
—
0
0
8
49
1.65
0.62
1.6
1.3
128.1
504.6
pmol/l
—
8
49
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
39
470
0.81
0.59
3.3
2.9
2.2
4.2
e6/l
1.18
19
243
8
53
1.52
0.59
1.0
1.8
—
—
—
0
0
11
161
0.67
0.58
3.3
3.2
61.8
53.4
ml/min/173m2
—
5
75
18
133
1.38
0.56
1.7
2.6
6.5
7.6
g/l
—
8
101
18
133
1.38
0.56
1.7
2.5
3.9
3.5
g/l
—
8
98
18
133
1.38
0.56
1.7
2.6
—
—
—
0
0
21
268
0.77
0.51
3.8
3.7
—
—
—
0
0
16
122
1.33
0.43
1.8
2.7
2.9
3.3
g/l
—
8
99
16
122
1.33
0.43
2.0
2.0
1.5
1.6
%
0.41
11
101
22
177
1.26
0.41
1.2
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
104.0
—
0
5
10
71
1.42
0.39
1.2
1.1
—
—
—
0
0
9
67
1.35
0.38
2.8
2.3
—
—
—
0
0
15
116
1.31
0.37
1.9
2.8
0.0
0.7
g/l
—
8
100
9
71
1.28
0.36
1.2
1.1
—
—
—
0
0
125
1178
1.10
0.34
5.2
4.1
0.0
0.0
estimate
0.00
14
228
14
109
1.30
0.34
1.9
2.3
38.7
36.4
g/l
—
8
95
7
52
1.35
0.31
1.3
1.3
—
—
—
0
0
8
63
1.28
0.28
2.5
2.0
—
—
—
0
0
8
64
1.26
0.27
1.1
1.2
—
—
—
0
0
8
64
1.26
0.27
1.1
1.2
—
—
—
0
0
5
38
1.32
0.23
4.6
3.6
40.6
61.0
u/ml
—
5
38
5
39
1.29
0.23
1.2
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
2.8
—
—
—
0
0
0
12
0.00
0.21
0.0
2.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
72.5
—
0
6
0
13
0.00
0.21
0.0
1.2
—
24.0
—
0
5
6
52
1.16
0.19
1.8
2.5
77.5
88.1
%
—
6
52
33
300
1.11
0.18
4.3
3.1
1.0
0.9
ug/l
0.34
24
213
8
68
1.18
0.16
2.9
2.4
26.8
25.8
mmol/l
—
8
53
8
96
0.83
0.14
2.5
2.4
0.0
0.0
g/l
—
8
88
120
1168
1.04
0.12
7.8
5.5
0.0
0.0
estimate
0.00
14
226
16
145
1.11
0.09
2.8
2.0
1.1
1.0
%
0.15
16
145
5
62
0.80
0.08
1.0
1.2
—
—
—
0
0
86
854
1.01
0.00
5.6
4.5
—
—
—
0
0
27
265
1.02
0.00
3.0
2.6
65.2
65.8
g/l
0.19
21
241
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
145.0
—
0
5
0
5
0.00
0.00
0.0
1.0
—
3.9
—
0
5
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
5
0.00
0.00
0.0
8.4
—
127.2
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
29
290
1.00
0.00
3.8
3.0
2.8
2.1
mmol/l
0.67
23
226
0
7
0.00
0.00
0.0
1.0
—
102.6
—
0
7
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
0.00
1.4
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_DISORDERLENSNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_DISORDERLENSNAS | 0.822 [0.71, 0.95] | 0.008 |
| Birth year | 0.991 [0.98, 1.0] | 0.045 |
During the follow-up period (1.1.1998 — 31.12.2019), 396 out of 1446 females with H7_DISORDERLENSNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_DISORDERLENSNAS | 0.896 [0.71, 1.13] | 0.349 |
| Birth year | 0.987 [0.98, 1.0] | 0.038 |
During the follow-up period (1.1.1998 — 31.12.2019), 167 out of 496 males with H7_DISORDERLENSNAS died.
Mortality risk
Mortality risk for people of age
years, who have H7_DISORDERLENSNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.07% | 0.164% |
| 5 | 0.401% | 1.067% |
| 10 | 1.029% | 2.606% |
| 15 | 1.935% | 5.137% |
| 20 | 3.429% | 8.56% |
Relationships between endpoints
↥Index endpoint: H7_DISORDERLENSNAS – Other specified and unspecified disorders of lens
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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