No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
174 |
4. Check minimum number of eventsNone |
174 |
5. Include endpointsNone |
174 |
6. Filter based on genotype QC (FinnGen only) |
166 |
Control definitions (FinnGen only)
- Control exclude
- H7_VISUALDISTBLIND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H54
- Name in latin
- Amaurosis oculorum amborum
Similar endpoints
↥List of similar endpoints to
Blindness or visual impairment, binocular
based on the number of shared cases.
Similar with more cases:
- Visual impairment including blindness (binocular or monocular)
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2294 | 1145 | 1123 |
| Only index persons | 1910 | 996 | 914 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 62.61 | 64.75 | 60.11 |
| Only index persons | 61.83 | 64.18 | 59.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 166 | 86 | 80 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | 58.79 | 55.36 | 62.47 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 174
- Matched controls
- 1739
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H54.0
ICD-10 Finland
Blindness, binocular
+∞
251.7
174
*
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
688.6
53.5
50
*
S01ED01
ATC
timolol; ophthalmic
13.9
35.6
36
32
Z3229
NOMESCO Finland
Other healthcare associate professional
7.8
30.2
50
85
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
8.5
28.7
43
65
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
53.4
26.5
31
7
S01ED51
ATC
timolol, combinations; ophthalmic
7.1
23.1
40
70
F94
ICPC
Blindness
+∞
22.4
21
*
114
Kela drug reimbursment
Glaucoma
6.0
21.5
45
95
R3120
NOMESCO Finland
Training in mobility skills
+∞
21.3
20
*
H54.1
ICD-10 Finland
Severe visual impairment, binocular
+∞
21.3
20
*
S01EC01
ATC
acetazolamide; systemic
25.3
20.3
28
13
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
224.4
20.0
20
*
H54.4
ICD-10 Finland
Blindness, monocular
+∞
19.1
18
*
AA1AD
NOMESCO Finland
CT of head and brain
4.2
18.8
78
284
XCK00
NOMESCO Finland
Perimetry
7.2
18.8
31
51
A28
ICPC
Limited function/disability NOS
4.5
18.7
61
186
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.3
17.2
60
191
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
4.7
16.4
45
119
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
5.7
15.7
33
69
Z96.1
ICD-10 Finland
Presence of intraocular lens
4.1
15.0
53
169
S01EA05
ATC
brimonidine; ophthalmic
17.4
14.9
23
15
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
6.8
14.8
25
42
S01EE01
ATC
latanoprost; ophthalmic
5.7
14.7
30
61
XCK10
NOMESCO Finland
Photography of fundus of eye
4.7
14.0
37
94
H16.0
ICD-10 Finland
Corneal ulcer
6.6
13.9
24
41
Z2446
NOMESCO Finland
Social worker
6.0
13.9
27
52
A10AB01
ATC
insulin (human); parenteral
6.2
13.0
24
44
H53.1
ICD-10 Finland
Subjective visual disturbances
19.2
12.8
19
11
A10AA02, ,
ATC
6.0
12.7
24
45
H47.2
ICD-10 Finland
Optic atrophy
+∞
12.6
12
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
11.8
12.2
22
21
CKD40
NOMESCO Finland
Endophotocoagulation of retina
16.2
12.1
19
13
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
50.3
12.1
14
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.0
11.8
96
501
Z02.4
ICD-10 Finland
Examination for driving licence
0.1
11.7
*
322
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
+∞
11.6
11
*
H44.5
ICD-10 Finland
Degenerated conditions of globe
+∞
11.6
11
*
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
128.1
11.6
12
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.4
11.2
31
81
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
46.5
11.1
13
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.7
11.0
42
139
S01BC03
ATC
diclofenac; ophthalmic
19.4
10.9
16
9
H3603, E103,
ICD-10 Finland
30.2
10.9
14
5
CKD15
NOMESCO Finland
Injection of vitreous substitute
64.0
10.8
12
*
H53.4
ICD-10 Finland
Visual field defects
64.0
10.8
12
*
H54.3
ICD-10 Finland
Mild or no visual impairment, binocular
116.7
10.5
11
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.9
10.5
35
105
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
10.5
10
*
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
25.2
10.4
14
6
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.3
10.3
48
180
S01BA01
ATC
dexamethasone; ophthalmic
9.7
10.1
20
23
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
42.7
10.1
12
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
18.1
10.1
15
9
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
21.6
10.0
14
7
127
Kela drug reimbursment
Transplant complication
21.6
10.0
14
7
H54.7
ICD-10 Finland
Unspecified visual loss
27.9
10.0
13
5
A10AC01
ATC
insulin (human); parenteral
3.9
9.9
33
99
WX140
NOMESCO Finland
Parabulbar anesthesy
5.8
9.9
19
36
H43.1
ICD-10 Finland
Vitreous haemorrhage
11.6
9.5
17
16
37520
ICD-8 Finland
Glaucoma, Secondary
105.5
9.5
10
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
23.2
9.5
13
6
3690A
ICD-9 Finland
Blindness and low vision, Profound impairment, both eyes
+∞
9.5
9
*
A10AA01, ,
ATC
7.5
9.2
21
31
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
38.9
9.1
11
*
Z94.0
ICD-10 Finland
Kidney transplant status
38.9
9.1
11
*
SPAT1229
SPAT
Assessment of need for aid
4.4
8.9
24
61
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
4.8
8.9
21
48
H04AA01
ATC
glucagon; nasal, parenteral
9.0
8.8
18
22
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
4.1
8.8
26
71
A10AB04
ATC
insulin lispro; parenteral
7.1
8.8
21
33
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.2
8.8
42
159
L28
ICPC
Limited function/disability (L)
3.1
8.7
45
178
ZXE10
NOMESCO Finland
More than one and less than three hours
2.6
8.6
78
414
CKD20
NOMESCO Finland
Removal of vitreous body substitute
29.1
8.6
11
*
TK800
NOMESCO Finland
Hemodialysis
13.7
8.5
14
11
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
94.4
8.5
9
*
Z94.7
ICD-10 Finland
Corneal transplant status
94.4
8.5
9
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
94.4
8.5
9
*
74483
ICD-8 Finland
Congenital anomalies of eye, Retinitis pigmentosa
+∞
8.4
8
*
H53.9
ICD-10 Finland
Visual disturbance, unspecified
12.6
8.2
14
12
S01FA01
ATC
atropine; ophthalmic
35.1
8.2
10
*
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
23.3
8.1
11
5
A10AE05
ATC
insulin detemir; parenteral
4.5
8.1
21
52
XCD10
NOMESCO Finland
Electrophysiological examination of eye
9.1
8.0
16
19
SPAT1231
SPAT
Assessment of adjustments needed in living environment
10.1
8.0
15
16
C03CA01
ATC
furosemide; systemic
2.5
7.9
75
404
H33.0
ICD-10 Finland
Retinal detachment with retinal break
7.3
7.8
18
27
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
7.8
90
528
N18.0
ICD-10 Finland
End-stage renal disease
47.1
7.8
9
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
47.1
7.8
9
*
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
47.1
7.8
9
*
CS494
NOMESCO Finland
Other visual field testing
12.6
7.7
13
11
V03AE01
ATC
polystyrene sulfonate; oral
19.4
7.7
11
6
A11CC03
ATC
alfacalcidol; systemic
10.0
7.4
14
15
S01EX03, ,
ATC
10.0
7.4
14
15
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
7.9
7.4
16
22
S01BC05
ATC
ketorolac; ophthalmic
4.8
7.3
17
38
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
7.3
7
*
L04AA01
ATC
[U] ciclosporin
16.6
7.3
11
7
ZXD05
NOMESCO Finland
Urgent procedure
2.4
7.2
68
361
H26.2
ICD-10 Finland
Complicated cataract
21.1
7.2
10
5
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
4.6
7.2
18
43
S01BA07
ATC
fluorometholone; ophthalmic
12.8
7.2
12
10
S01EC54
ATC
brinzolamide, combinations; ophthalmic
14.6
7.0
11
8
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.3
6.9
79
455
XF400
NOMESCO Finland
ECG with 12 standard connections
2.8
6.9
40
167
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
9.9
6.9
13
14
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
6.9
63
329
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
17.5
6.8
10
6
S01EB01
ATC
pilocarpine; ophthalmic
23.6
6.7
9
*
H46
ICD-10 Finland
Optic neuritis
23.6
6.7
9
*
A10AB05
ATC
insulin aspart; parenteral
3.3
6.7
27
91
A10AE04
ATC
insulin glargine; parenteral
3.1
6.6
30
109
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.8
6.6
39
165
S01AA01
ATC
chloramphenicol; ophthalmic
6.0
6.5
17
31
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
15.0
6.5
10
7
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
15.0
6.5
10
7
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
15.0
6.5
10
7
2504B
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYYPPI I]
72.4
6.5
7
*
TCG10
NOMESCO Finland
Removal of sutures from cornea
72.4
6.5
7
*
DFF00
NOMESCO Finland
Pure tone audiometry
3.1
6.4
29
105
N05CD07
ATC
temazepam; oral
3.0
6.4
31
117
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.0
6.4
31
117
NH1BA
NOMESCO Finland
Ankle extensive X-ray examination
9.8
6.4
12
13
N05AX08
ATC
risperidone; systemic
3.1
6.3
28
100
S01EC04
ATC
brinzolamide; ophthalmic
5.8
6.3
17
32
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
6.3
54
272
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.3
6.3
76
444
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
18.9
6.3
9
5
3711
FHL
Cyclodiateria or cryocoagulation
+∞
6.3
6
*
37909
ICD-8 Finland
Blindness, both eyes, specifically defined
+∞
6.3
6
*
2503B
ICD-9 Finland
Diabetes mellitus, Diabetes with other coma[SOKERITAUDIN AIHEUTTAMA MUNUAISSAIRAUS,TYYPPI I]
+∞
6.3
6
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.5
6.3
23
73
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.2
6.3
27
95
N03AX09
ATC
lamotrigine; oral
5.6
6.2
17
33
S01EE03
ATC
bimatoprost; ophthalmic
9.1
6.2
12
14
R4120
NOMESCO Finland
Occupational therapy
4.2
6.1
17
44
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
10.6
6.1
11
11
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.3
6.0
16
40
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
50
180
3.49
11.55
12.6
5.8
1.09
1.06
mmol/l
0.31
44
160
77
389
2.75
9.58
3.1
2.0
288.42
220.80
u/l
0.22
72
364
31
97
3.67
8.71
7.7
4.1
121.64
74.43
ng/l
1.26
25
84
96
586
2.42
7.56
13.8
5.9
1.21
1.21
mmol/l
0.09
83
541
48
217
2.67
7.14
2.3
2.0
—
—
—
0
0
51
242
2.56
6.85
2.0
1.8
1144.46
1234.44
nmol/l
0.27
39
190
91
565
2.28
6.62
8.9
4.7
33.76
35.63
g/l
1.95
74
530
18
50
3.90
5.93
2.7
1.8
—
—
—
0
0
112
780
2.22
5.89
11.3
4.5
7.42
6.74
mmol/l
1.90
107
724
18
53
3.67
5.47
2.9
2.1
—
—
—
0
0
96
642
2.10
5.45
16.8
6.9
1.20
1.22
mmol/l
0.74
78
540
34
149
2.59
5.28
5.5
4.5
32.75
31.59
%
0.19
24
103
20
65
3.34
5.25
1.9
1.8
—
—
—
0
0
93
626
2.04
5.06
19.6
14.0
1.22
1.29
inr
0.26
18
189
82
531
2.03
4.94
3.2
2.4
73.92
76.85
nmol/l
0.40
72
479
8
7
11.89
4.83
8.9
3.1
—
—
—
0
0
0
118
0.00
4.76
0.0
1.8
—
—
—
0
0
15
43
3.72
4.72
1.3
1.3
—
—
—
0
0
101
716
1.98
4.59
7.3
6.0
9.26
11.51
umol/l
2.77
90
678
81
536
1.95
4.47
5.4
4.0
143.39
32.59
ng/l
0.58
64
377
31
141
2.46
4.44
11.3
8.5
—
—
—
0
0
26
109
2.63
4.39
2.8
2.7
9.59
6.33
ug/l
0.32
17
97
132
1042
2.10
4.27
11.2
7.1
86.44
76.81
u/l
1.71
117
975
31
147
2.35
4.05
1.5
1.9
—
—
—
0
0
23
95
2.64
4.00
1.8
1.6
—
—
—
0
0
76
514
1.85
3.77
2.4
2.0
108.08
97.14
pmol/l
0.88
43
279
6
6
10.29
3.52
1.8
1.0
—
—
—
0
0
30
150
2.21
3.46
2.5
3.7
4.33
9.96
umol/l
2.36
21
130
29
149
2.13
3.12
1.7
2.0
—
—
—
0
0
51
323
1.82
3.02
1.7
1.6
20.67
20.69
nmol/l
0.00
43
273
5
6
8.53
2.76
1.6
2.0
—
—
—
0
0
5
6
8.53
2.76
1.6
2.0
—
—
—
0
0
48
306
1.78
2.76
1.7
1.8
419.88
429.07
pmol/l
0.08
40
256
49
315
1.77
2.74
3.0
2.1
3.46
3.20
mg/l
0.30
39
272
11
36
3.19
2.61
2.0
2.2
—
—
—
0
0
63
440
1.68
2.60
5.5
3.7
2.35
2.36
mmol/l
0.05
50
386
5
7
7.31
2.56
1.0
1.1
—
—
—
0
0
5
7
7.31
2.56
1.6
2.0
—
—
—
0
0
5
7
7.31
2.56
1.6
2.0
—
—
—
0
0
5
7
7.31
2.56
1.2
2.1
—
—
—
0
0
5
7
7.31
2.56
1.2
2.1
—
—
—
0
0
5
7
7.31
2.56
1.4
2.1
—
—
—
0
0
10
31
3.36
2.56
1.5
1.4
—
—
—
0
0
10
31
3.36
2.56
1.5
1.4
—
—
—
0
0
8
21
3.94
2.49
1.7
1.5
—
—
—
0
0
12
46
2.73
2.41
1.3
1.2
—
—
—
0
0
5
8
6.39
2.38
1.2
2.0
—
—
—
0
0
5
8
6.39
2.38
2.4
2.0
—
—
—
0
0
5
8
6.39
2.38
1.2
2.0
—
—
—
0
0
26
143
1.96
2.34
3.5
3.4
—
—
—
0
0
9
28
3.33
2.34
1.1
1.8
—
—
—
0
0
12
47
2.67
2.32
1.3
1.2
—
—
—
0
0
7
18
4.00
2.27
1.1
1.9
—
—
—
0
0
138
1199
1.73
2.23
5.7
4.6
1.97
1.93
mu/l
0.11
118
1090
61
438
1.60
2.21
6.7
2.4
48.09
68.02
u/l
1.17
53
405
152
1360
1.93
2.20
37.0
16.4
139.38
139.67
mmol/l
0.72
143
1328
11
42
2.72
2.18
1.5
1.2
—
—
—
0
0
152
1363
1.91
2.14
36.3
16.5
4.01
3.97
mmol/l
0.89
143
1327
29
171
1.83
2.13
15.1
5.7
103.21
104.03
mmol/l
0.46
29
171
66
487
1.57
2.12
6.1
3.0
—
—
—
0
0
7
21
3.43
1.98
1.1
1.8
—
—
—
0
0
38
249
1.67
1.95
3.6
3.8
33.81
139.24
ng/l
1.37
28
197
6
16
3.84
1.95
2.0
1.9
—
—
—
0
0
6
16
3.84
1.95
2.0
1.9
—
—
—
0
0
6
16
3.84
1.95
2.0
1.9
—
—
—
0
0
6
16
3.84
1.95
2.0
1.9
—
—
—
0
0
6
16
3.84
1.95
2.0
1.9
—
—
—
0
0
6
16
3.84
1.95
2.0
1.9
—
—
—
0
0
8
28
2.94
1.88
1.9
1.7
—
—
—
0
0
8
30
2.74
1.74
18.0
1.1
1.13
0.77
nmol/l
—
8
25
147
1327
1.69
1.73
31.3
14.4
26.81
23.38
mg/l
0.51
123
1037
5
13
3.92
1.72
1.4
1.2
—
—
—
0
0
5
13
3.92
1.72
1.0
1.2
—
—
—
0
0
5
14
3.64
1.62
1.2
2.1
—
—
—
0
0
5
14
3.64
1.62
1.2
2.1
—
—
—
0
0
5
14
3.64
1.62
1.2
2.1
—
—
—
0
0
114
981
1.47
1.59
5.0
3.8
15.14
14.66
pmol/l
1.16
102
885
5
15
3.40
1.53
1.8
3.7
—
—
—
0
0
43
308
1.53
1.53
1.3
1.3
0.89
1.49
u/ml
—
8
88
6
21
2.92
1.52
1.8
1.7
2.85
181.36
u/ml
—
6
21
6
21
2.92
1.52
1.2
1.9
—
—
—
0
0
53
399
1.47
1.48
6.4
3.7
20.58
8.37
mg/mmol
1.06
37
256
41
293
1.52
1.47
4.2
2.3
—
—
—
0
0
9
39
2.38
1.45
1.2
1.7
—
—
—
0
0
94
789
1.41
1.45
11.8
9.3
4.98
4.16
e9/l
0.82
84
696
9
40
2.32
1.42
1.1
1.7
—
—
—
0
0
112
973
1.42
1.40
4.8
4.0
17.97
11.77
mm/h
2.72
101
897
100
854
1.40
1.37
3.8
3.1
48.37
48.91
u/l
0.03
90
804
14
76
1.91
1.34
1.5
1.4
—
—
—
0
0
6
24
2.55
1.31
1.3
1.1
—
—
—
0
0
10
49
2.10
1.24
1.9
2.6
—
—
—
0
0
29
201
1.53
1.19
3.6
2.9
3.47
2.07
e6/l
0.47
19
114
49
378
1.41
1.19
4.7
4.0
0.00
0.00
estimate
-0.00
15
130
5
20
2.54
1.16
1.2
1.8
—
—
—
0
0
49
382
1.39
1.11
4.7
2.8
0.21
0.39
e6/l
0.86
40
288
5
21
2.42
1.09
1.8
1.8
—
99.33
—
0
6
43
330
1.40
1.07
4.1
3.0
400.73
6872.64
umol/l
1.53
33
282
30
217
1.46
1.02
3.7
2.6
1.11
1.07
e6/l
0.02
20
129
136
1253
1.39
0.99
6.0
4.6
6.52
6.03
mmol/l
1.28
120
1148
5
23
2.21
0.98
1.2
1.8
—
—
—
0
0
13
77
1.74
0.98
1.3
1.3
—
—
—
0
0
50
401
1.35
0.95
3.6
3.4
2469.83
1368.56
ng/l
0.68
42
331
150
1409
1.46
0.94
15.7
10.1
27.46
25.83
u/l
0.50
142
1358
6
28
2.18
0.92
1.2
1.9
—
—
—
0
0
6
28
2.18
0.92
1.2
1.9
—
—
—
0
0
32
240
1.41
0.91
4.1
3.0
2.47
2.45
mmol/l
0.17
26
206
6
29
2.10
0.90
1.2
1.8
—
—
—
0
0
15
96
1.61
0.87
2.1
3.0
65.88
65.51
ml/min/173m2
—
8
37
15
220
0.65
0.81
1.2
1.2
12.20
30.17
iu/ml
—
5
71
0
24
0.00
0.80
0.0
3.4
—
—
—
0
0
36
283
1.34
0.78
2.7
1.9
1.30
1.30
mg/l
0.00
26
227
154
1471
1.40
0.69
42.8
21.1
246.46
246.45
e9/l
0.00
147
1442
5
27
1.88
0.69
1.4
1.7
—
—
—
0
0
7
43
1.65
0.67
4.0
2.8
25.41
24.67
mmol/l
—
7
43
154
1473
1.39
0.66
43.4
21.1
38.77
40.13
%
2.15
139
1399
154
1474
1.38
0.65
43.3
21.1
4.33
4.49
e12/l
2.90
147
1437
154
1476
1.37
0.62
43.5
21.2
129.80
135.37
g/l
4.20
148
1456
0
21
0.00
0.60
0.0
1.0
—
1.31
—
0
15
9
59
1.55
0.56
2.8
3.4
8.56
648.76
u/ml
—
9
51
42
354
1.24
0.55
1.7
1.7
1.54
1.33
mmol/l
0.70
35
298
9
63
1.45
0.53
7.2
2.7
1.23
1.12
%
—
9
63
11
156
0.68
0.52
2.8
2.1
—
—
—
0
0
137
1304
1.24
0.50
5.7
4.9
2.59
2.70
mmol/l
0.62
117
1200
128
1215
1.20
0.45
9.1
5.9
44.21
40.27
mmol/mol
2.26
112
1140
27
325
0.80
0.45
5.5
4.5
33.51
23.24
%
1.92
13
158
67
603
1.18
0.45
3.6
2.6
—
—
—
0
0
72
652
1.18
0.45
4.4
3.8
0.00
0.00
estimate
-0.00
15
146
10
69
1.48
0.45
1.1
1.0
—
—
—
0
0
5
34
1.48
0.40
2.0
1.3
—
—
—
0
0
129
1231
1.18
0.40
4.9
4.0
1.56
1.28
mmol/l
2.37
108
1123
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
19
234
0.79
0.39
2.8
2.9
1.08
0.76
ug/l
—
10
155
72
659
1.16
0.38
4.4
3.8
0.00
0.00
estimate
-0.00
15
128
145
1400
1.21
0.37
33.5
16.7
89.19
78.84
umol/l
1.49
145
1400
71
654
1.14
0.34
5.4
5.1
0.00
0.00
estimate
-0.00
15
135
133
1283
1.15
0.30
5.4
4.4
4.46
4.61
mmol/l
0.64
114
1190
132
1275
1.14
0.28
5.4
4.4
1.31
1.46
mmol/l
4.22
113
1172
11
139
0.78
0.28
2.5
2.0
—
—
—
0
0
16
192
0.82
0.27
1.7
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.8
—
977.60
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
196.41
—
0
12
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
38.13
—
0
8
0
14
0.00
0.20
0.0
1.0
—
451.75
—
0
8
6
51
1.18
0.19
1.2
2.4
7.41
3.38
mg/l
—
6
37
126
1234
1.07
0.12
25.5
13.7
73.96
80.29
ml/min/173m2
1.67
98
1006
24
220
1.10
0.12
1.6
1.5
—
—
—
0
0
80
825
0.94
0.11
3.4
3.1
—
—
—
0
0
5
46
1.09
0.09
5.0
2.3
—
—
—
0
0
45
431
1.06
0.08
4.3
4.9
2.10
2.12
ug/l
0.02
34
376
54
529
1.03
0.03
4.5
3.9
—
—
—
0
0
0
7
0.00
0.00
0.0
3.0
—
12.81
—
0
7
0
8
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
24.94
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.3
—
62.67
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
7.28
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
7.0
—
235.50
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
64.02
—
0
5
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_VISIMPBILATERAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_VISIMPBILATERAL | 2.117 [1.63, 2.75] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.088 |
During the follow-up period (1.1.1998 — 31.12.2019), 416 out of 1022 females with H7_VISIMPBILATERAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_VISIMPBILATERAL | 2.19 [1.67, 2.87] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 413 out of 986 males with H7_VISIMPBILATERAL died.
Mortality risk
Mortality risk for people of age
years, who have H7_VISIMPBILATERAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.167% | 0.477% |
| 5 | 0.988% | 2.345% |
| 10 | 2.677% | 6.198% |
| 15 | 5.119% | 11.656% |
| 20 | 9.06% | 20.056% |
Relationships between endpoints
↥Index endpoint: H7_VISIMPBILATERAL – Blindness or visual impairment, binocular
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data