Blindness or visual impairment, binocular

H7_VISIMPBILATERAL

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H54.0
  • Cause of death: ICD-10 H54.0

2 out of 7 registries used, show all original rules.

164

4. Check minimum number of events

None

164

5. Include endpoints

None

164

6. Filter based on genotype QC (FinnGen only)

164

Control definitions (FinnGen only)

Control exclude
H7_VISUALDISTBLIND

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H54
Name in latin
Amaurosis oculorum amborum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2294 1145 1123
Only index persons 1910 996 914
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.04 0.04 0.03
Median age at first event (years)
Whole population 62.61 64.75 60.11
Only index persons 61.83 64.18 59.26

-FinnGen-

Key figures

All Female Male
Number of individuals 164 87 77
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 56.94 52.90 61.49

-FinRegistry-

Age distribution of first events

0102030405060708090050100150200250300350400AgeIndividuals

-FinnGen-

Age distribution of first events

020304050607080900246810121416182022242628AgeIndividuals

-FinRegistry-

Year distribution of first events

19701975198019851990200020052010201520202022050100150200250300350400450500550600YearIndividuals

-FinnGen-

Year distribution of first events

1970197519801985199019952000200520102015202020230510152025303540YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
146
Matched controls
1457
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H54.0
ICD-10 Finland
Blindness, binocular
+∞
211.0
146
*
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
321.6
46.9
45
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
119.6
27.8
29
*
S01EC01
ATC
acetazolamide; systemic
37.2
20.0
25
8
S01ED01
ATC
timolol; ophthalmic
15.4
18.7
31
25
H54.1
ICD-10 Finland
Severe visual impairment, binocular
+∞
17.0
16
*
AA1AD
NOMESCO Finland
CT of head and brain
5.1
16.4
64
195
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
+∞
15.9
15
*
F94
ICPC
Blindness
+∞
15.9
15
*
R3120
NOMESCO Finland
Training in mobility skills
178.2
15.8
16
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
23.2
15.7
22
11
114
Kela drug reimbursment
Glaucoma
7.4
15.1
38
66
H54.4
ICD-10 Finland
Blindness, monocular
165.8
14.7
15
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.4
14.2
48
122
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
7.9
14.0
33
52
S01ED51
ATC
timolol, combinations; ophthalmic
7.7
13.4
32
51
A10AA02
ATC
NA
10.8
12.6
24
26
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
5.9
12.5
37
79
CKD40
NOMESCO Finland
Endophotocoagulation of retina
29.6
12.3
16
6
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
10.4
12.3
24
27
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.4
12.1
39
92
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
14.3
12.0
20
16
A28
ICPC
Limited function/disability NOS
4.7
11.7
44
123
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
+∞
11.6
11
*
H54.7
ICD-10 Finland
Unspecified visual loss
129.7
11.6
12
*
A10AA01
ATC
NA
11.5
11.4
21
21
H04AA01
ATC
glucagon; nasal, parenteral
15.6
11.3
18
13
H33.0
ICD-10 Finland
Retinal detachment with retinal break
17.3
11.1
17
11
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
10.8
10.7
20
21
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
25.6
10.5
14
6
H53.1
ICD-10 Finland
Subjective visual disturbances
21.9
10.0
14
7
XCK00
NOMESCO Finland
Perimetry
7.6
9.9
23
35
37520
ICD-8 Finland
Glaucoma, Secondary
106.6
9.5
10
*
H33.4
ICD-10 Finland
Traction detachment of retina
106.6
9.5
10
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
23.6
9.5
13
6
H3603, E103
ICD-10 Finland
NA
23.6
9.5
13
6
H44.5
ICD-10 Finland
Degenerated conditions of globe
+∞
9.5
9
*
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
+∞
9.5
9
*
H53.4
ICD-10 Finland
Visual field defects
+∞
9.5
9
*
127
Kela drug reimbursment
Transplant complication
20.2
9.1
13
7
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
5.1
9.1
29
67
XCK10
NOMESCO Finland
Photography of fundus of eye
5.0
9.1
30
72
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
25.9
9.1
12
5
S01EE01
ATC
latanoprost; ophthalmic
6.0
8.8
24
46
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
53.2
8.8
10
*
S01FA01
ATC
atropine; ophthalmic
53.2
8.8
10
*
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
5.2
8.6
27
61
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
21.6
8.6
12
6
Z49.1
ICD-10 Finland
Extracorporeal dialysis
21.6
8.6
12
6
CKD15
NOMESCO Finland
Injection of vitreous substitute
95.3
8.5
9
*
3690A
ICD-9 Finland
Blindness and low vision, Profound impairment, both eyes
+∞
8.4
8
*
Z02.4
ICD-10 Finland
Examination for driving licence
0.0
8.3
*
193
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
35.5
8.2
10
*
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
23.6
8.1
11
5
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.7
8.1
38
127
SPAT1231
SPAT
Assessment of adjustments needed in living environment
14.1
8.0
13
10
H16.0
ICD-10 Finland
Corneal ulcer
7.1
8.0
19
30
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.7
8.0
37
122
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.8
7.9
72
379
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
47.5
7.8
9
*
TK800
NOMESCO Finland
Hemodialysis
12.8
7.7
13
11
V03AE01
ATC
polystyrene sulfonate; oral
19.6
7.7
11
6
Z94.0
ICD-10 Finland
Kidney transplant status
19.6
7.7
11
6
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
19.6
7.7
11
6
H43.1
ICD-10 Finland
Vitreous haemorrhage
10.9
7.7
14
14
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.9
7.7
25
59
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
26.6
7.7
10
*
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
9.1
7.5
15
18
H54.3
ICD-10 Finland
Mild or no visual impairment, binocular
84.1
7.5
8
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
84.1
7.5
8
*
N03AX09
ATC
lamotrigine; oral
10.2
7.5
14
15
XCD10
NOMESCO Finland
Electrophysiological examination of eye
11.7
7.5
13
12
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
8.0
7.4
16
22
H47.2
ICD-10 Finland
Optic atrophy
+∞
7.3
7
*
S01EX03
ATC
NA
12.9
7.2
12
10
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.7
7.2
32
102
N05AH04
ATC
quetiapine; oral
3.6
7.2
34
114
S01BC03
ATC
diclofenac; ophthalmic
9.0
7.0
14
17
L28
ICPC
Limited function/disability (L)
3.4
7.0
35
123
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
6.9
73
410
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
6.5
6.8
17
29
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
5.3
6.8
20
42
L04AA01
ATC
[U] ciclosporin; systemic
17.7
6.8
10
6
H26.2
ICD-10 Finland
Complicated cataract
17.7
6.8
10
6
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
9.4
6.7
13
15
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
13.1
6.7
11
9
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
10.8
6.7
12
12
A11CC03
ATC
alfacalcidol; systemic
10.8
6.7
12
12
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
10.8
6.7
12
12
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
8.0
6.6
14
19
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.1
6.5
25
70
H46
ICD-10 Finland
Optic neuritis
72.9
6.5
7
*
2504B
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYYPPI I]
72.9
6.5
7
*
N05AX08
ATC
risperidone; systemic
4.5
6.4
22
55
S01EC04
ATC
brinzolamide; ophthalmic
6.8
6.4
15
24
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
19.0
6.3
9
5
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
19.0
6.3
9
5
E10
ICD-10 Finland
Type 1 diabetes mellitus
19.0
6.3
9
5
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
19.0
6.3
9
5
SPAT1229
SPAT
Assessment of need for aid
4.4
6.3
22
56
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
+∞
6.3
6
*
74483
ICD-8 Finland
Congenital anomalies of eye, Retinitis pigmentosa
+∞
6.3
6
*
37909
ICD-8 Finland
Blindness, both eyes, specifically defined
+∞
6.3
6
*
N06AX11
ATC
mirtazapine; oral
2.6
6.2
56
282
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.7
6.0
49
233

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
76
362
3.05
11.01
3.1
2.0
291.61
214.56
u/l
0.25
71
340
47
168
3.52
11.01
12.0
6.0
1.09
1.05
mmol/l
0.48
41
151
30
91
3.81
8.85
7.4
4.3
111.17
75.66
ng/l
0.93
24
82
18
42
4.69
7.42
3.3
3.5
24.11
20.46
s
0.61
18
37
35
132
3.10
7.31
2.4
1.5
—
—
—
0
0
90
548
2.42
7.15
13.6
6.1
1.21
1.21
mmol/l
0.05
76
506
62
328
2.43
6.65
6.9
4.1
—
—
—
0
0
47
229
2.47
5.94
2.0
1.7
1140.91
1214.97
nmol/l
0.20
35
183
84
531
2.19
5.72
8.8
4.7
33.93
35.74
g/l
1.74
68
498
105
736
2.18
5.37
11.6
4.5
7.39
6.76
mmol/l
1.58
100
682
80
506
2.13
5.33
10.3
8.0
1.21
1.25
inr
0.14
17
156
23
82
3.10
5.23
9.4
4.0
5.41
5.08
kpa
0.91
23
75
90
600
2.11
5.18
16.2
7.1
1.21
1.22
mmol/l
0.50
72
505
14
38
3.93
4.75
8.4
3.6
—
—
—
0
0
25
102
2.71
4.47
2.8
2.7
10.04
6.30
ug/l
0.35
16
91
61
368
2.05
4.44
3.6
3.2
—
—
—
0
0
17
57
3.21
4.26
10.5
4.7
—
—
—
0
0
65
409
1.97
4.16
8.5
5.5
—
—
—
0
0
125
985
2.13
4.13
11.1
7.2
86.61
77.04
u/l
1.57
111
921
95
686
1.91
3.98
7.5
6.1
9.47
11.36
umol/l
1.98
84
651
0
102
0.00
3.97
0.0
1.3
—
—
—
0
0
6
5
12.37
3.79
5.0
2.0
—
—
—
0
0
75
508
1.88
3.77
5.6
3.9
152.53
33.43
ng/l
0.57
59
358
56
347
1.93
3.67
5.1
4.1
—
—
—
0
0
29
140
2.30
3.65
2.6
3.8
4.45
9.10
umol/l
2.08
20
121
71
480
1.84
3.54
2.4
2.0
105.88
97.41
pmol/l
0.66
39
263
58
377
1.83
3.22
8.6
4.2
7.40
7.40
ph
0.25
12
69
8
18
4.61
2.83
3.1
4.1
—
—
—
0
0
25
440
0.49
2.78
3.7
3.0
—
—
—
0
0
21
100
2.26
2.72
14.3
5.7
—
—
—
0
0
43
269
1.81
2.65
3.3
2.5
4.54
5.49
e6/l
0.43
37
241
85
648
1.65
2.53
8.8
6.1
0.23
0.19
e9/l
0.51
76
581
78
585
1.63
2.46
9.2
5.8
3.18
2.77
%
0.79
72
548
78
586
1.63
2.43
10.5
6.2
8.40
8.57
%
0.16
72
551
37
227
1.81
2.42
3.6
3.9
33.47
147.62
ng/l
1.36
27
180
45
295
1.72
2.35
2.9
2.1
3.43
3.16
mg/l
0.30
36
259
82
628
1.61
2.34
8.9
5.7
0.04
0.04
e9/l
0.12
73
555
59
417
1.65
2.32
5.6
3.7
2.36
2.35
mmol/l
0.03
47
363
43
280
1.72
2.29
1.6
1.7
417.17
426.40
pmol/l
0.07
36
239
15
67
2.36
2.25
9.9
4.6
22.65
24.55
mmol/l
2.24
15
60
5
9
5.68
2.23
1.0
1.1
—
—
—
0
0
20
102
2.09
2.21
13.0
7.8
—
—
—
0
0
46
309
1.68
2.19
1.6
1.6
21.08
20.77
nmol/l
0.04
39
263
6
14
4.40
2.17
4.8
2.9
—
—
—
0
0
75
570
1.58
2.17
8.3
5.8
0.52
0.63
%
1.08
69
530
81
627
1.58
2.16
9.2
5.6
0.61
0.59
e9/l
0.22
73
551
38
245
1.72
2.09
3.4
2.7
504.03
543.40
mosm/kgh2o
0.51
33
210
7
20
3.61
2.08
2.0
1.5
—
—
—
0
0
49
340
1.63
2.05
4.6
2.9
—
—
—
0
0
22
121
1.94
2.00
7.2
4.3
—
—
—
0
0
18
92
2.07
1.99
11.0
3.8
—
—
—
0
0
11
45
2.55
1.97
1.9
1.6
—
—
—
0
0
82
646
1.54
1.97
9.2
5.7
2.05
1.97
e9/l
0.08
73
580
7
22
3.27
1.90
3.9
2.4
—
—
—
0
0
77
604
1.52
1.86
9.6
5.9
25.94
27.58
%
0.55
71
564
53
383
1.57
1.85
5.4
2.9
5.60
7.64
mmol/l
3.43
45
320
30
188
1.73
1.82
2.3
1.6
—
—
—
0
0
75
587
1.51
1.82
9.0
5.8
58.53
57.60
%
0.22
69
552
7
23
3.13
1.82
2.7
4.7
—
—
—
0
0
11
47
2.44
1.82
1.4
1.2
—
—
—
0
0
142
1284
1.78
1.76
37.1
16.3
139.43
139.65
mmol/l
0.45
134
1254
18
97
1.96
1.74
1.4
1.5
—
—
—
0
0
142
1287
1.77
1.70
36.4
16.4
4.00
3.97
mmol/l
0.80
134
1253
14
69
2.12
1.70
6.3
7.4
24.56
24.83
mmol/l
0.11
14
63
56
417
1.52
1.69
7.2
2.3
49.08
57.40
u/l
1.63
48
383
6
19
3.23
1.67
1.5
1.2
—
—
—
0
0
128
1133
1.59
1.65
5.7
4.6
1.99
1.93
mu/l
0.18
109
1030
25
153
1.75
1.65
2.5
1.6
—
—
—
0
0
52
384
1.52
1.63
4.4
3.1
19.32
220.45
e6/l
0.64
40
299
41
290
1.55
1.55
1.3
1.3
0.89
1.54
u/ml
—
8
82
7
28
2.56
1.47
20.4
1.1
1.14
0.76
nmol/l
—
7
23
5
16
3.19
1.45
2.6
4.4
—
—
—
0
0
6
22
2.79
1.44
1.3
1.2
—
—
—
0
0
14
74
1.97
1.44
2.7
3.0
—
—
—
0
0
47
349
1.48
1.42
4.7
2.9
0.21
0.38
e6/l
0.81
39
261
14
75
1.95
1.39
6.1
7.2
24.97
24.84
mmol/l
0.05
14
75
99
847
1.42
1.39
8.6
4.2
—
—
—
0
0
51
387
1.46
1.38
3.8
2.5
—
—
—
0
0
12
61
2.04
1.36
2.5
2.4
—
—
—
0
0
47
352
1.47
1.36
5.6
3.0
79.47
234.13
mg/l
0.41
35
231
23
146
1.67
1.35
1.4
1.4
—
—
—
0
0
0
41
0.00
1.33
0.0
4.5
—
—
—
0
0
137
1252
1.57
1.32
31.7
14.3
27.35
23.22
mg/l
0.61
116
982
43
321
1.46
1.26
10.3
7.8
—
—
—
0
0
106
928
1.40
1.24
4.9
3.8
15.05
14.67
pmol/l
0.76
94
841
105
918
1.40
1.23
4.7
3.9
17.57
11.66
mm/h
2.60
94
845
36
261
1.48
1.21
2.7
1.9
1.30
1.33
mg/l
0.02
26
210
27
186
1.54
1.15
3.0
1.8
—
—
—
0
0
16
96
1.74
1.15
2.3
3.4
0.20
0.16
%
—
5
31
87
744
1.36
1.14
11.9
9.5
5.07
4.12
e9/l
0.94
78
655
37
275
1.45
1.10
4.6
3.8
—
—
—
0
0
48
375
1.39
1.09
6.4
3.8
16.16
8.66
mg/mmol
0.65
33
239
10
52
1.98
1.08
21.5
4.1
—
—
—
0
0
27
189
1.51
1.08
3.7
2.9
3.44
2.16
e6/l
0.38
18
104
45
349
1.40
1.07
4.8
3.9
0.00
0.00
estimate
0.00
13
116
7
37
1.93
0.95
4.0
2.5
25.41
24.48
mmol/l
—
7
32
16
102
1.63
0.94
8.9
3.8
—
—
—
0
0
15
94
1.65
0.94
2.3
3.1
3.80
0.56
%
—
5
25
27
360
0.70
0.90
4.1
3.3
—
—
—
0
0
6
29
2.11
0.90
5.5
3.0
—
—
—
0
0
30
223
1.42
0.90
4.2
3.0
2.47
2.45
mmol/l
0.35
24
195
140
1314
1.44
0.88
28.6
13.4
—
—
—
0
0
8
44
1.86
0.87
21.6
3.3
3.91
3.98
mmol/l
—
8
39
40
315
1.36
0.86
3.9
3.0
390.97
6155.89
umol/l
1.30
30
271
54
445
1.32
0.86
5.3
3.7
79.18
74.93
e6/l
0.03
43
323
141
1327
1.44
0.85
15.8
10.2
27.92
25.90
u/l
0.63
134
1279
14
89
1.63
0.84
10.4
2.9
3.75
3.90
e9/l
—
8
73
6
34
1.79
0.77
1.0
1.1
—
—
—
0
0
5
23
2.21
0.77
1.4
1.8
—
—
—
0
0
16
108
1.53
0.76
2.3
3.3
4.00
0.89
%
—
5
37
9
56
1.64
0.73
2.8
3.4
8.56
175.23
u/ml
—
9
48
11
68
1.66
0.73
8.2
8.2
—
—
—
0
0
28
215
1.36
0.71
2.8
2.0
—
—
—
0
0
56
475
1.27
0.71
4.2
3.7
—
—
—
0
0
126
1181
1.29
0.65
5.9
4.6
6.47
6.03
mmol/l
1.01
112
1083
16
219
0.70
0.63
2.8
2.8
1.05
0.72
ug/l
—
9
145
0
22
0.00
0.60
0.0
2.8
—
—
—
0
0
0
23
0.00
0.58
0.0
2.7
—
3.97
—
0
23
0
23
0.00
0.58
0.0
2.7
—
106.96
—
0
23
15
204
0.71
0.57
1.2
1.2
12.20
31.72
iu/ml
—
5
66
8
55
1.48
0.57
1.3
1.2
—
—
—
0
0
9
60
1.53
0.55
7.2
2.8
1.23
1.15
%
—
9
60
17
126
1.39
0.54
1.5
1.4
—
—
—
0
0
6
39
1.56
0.53
1.7
1.2
—
—
—
0
0
15
109
1.41
0.53
5.9
3.3
—
—
—
0
0
7
109
0.63
0.50
1.1
1.5
—
—
—
0
0
144
1387
1.31
0.48
42.6
21.0
247.94
247.06
e9/l
0.05
138
1359
10
68
1.50
0.48
1.0
1.2
—
31.20
—
0
5
144
1389
1.30
0.45
43.1
20.9
91.14
91.05
fl
0.08
138
1371
144
1390
1.29
0.44
43.2
21.0
7.58
6.77
e9/l
1.57
138
1357
144
1390
1.29
0.44
43.1
20.8
30.26
30.32
pg
0.14
138
1372
144
1390
1.29
0.44
43.2
21.0
4.34
4.49
e12/l
2.53
138
1355
5
31
1.63
0.43
30.4
11.5
—
—
—
0
0
144
1391
1.28
0.43
43.4
21.1
130.19
135.45
g/l
3.62
139
1371
5
33
1.53
0.41
1.2
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
0.04
—
0
5
67
609
1.17
0.40
4.4
3.7
0.00
0.00
estimate
0.00
13
124
0
18
0.00
0.40
0.0
1.0
—
0.13
—
0
9
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
7.01
—
0
13
5
35
1.44
0.39
2.2
1.2
0.20
0.23
g/l
—
5
35
8
114
0.69
0.38
1.3
1.8
—
—
—
0
0
5
36
1.40
0.38
1.0
1.3
—
—
—
0
0
20
162
1.27
0.37
1.5
1.3
—
—
—
0
0
24
284
0.82
0.35
4.9
4.5
—
—
—
0
0
12
92
1.33
0.32
2.4
3.4
0.00
0.32
%
—
5
28
67
619
1.14
0.31
4.4
3.7
0.00
0.00
estimate
0.00
13
113
55
503
1.14
0.29
2.7
2.1
—
—
—
0
0
119
1143
1.15
0.29
9.0
5.9
44.15
40.23
mmol/mol
2.06
104
1069
127
1227
1.15
0.28
5.6
4.9
2.62
2.70
mmol/l
0.34
108
1127
136
1321
1.17
0.27
33.4
16.6
87.92
78.44
umol/l
1.31
136
1321
17
141
1.23
0.27
1.8
2.2
192.70
169.38
ug/g
—
10
110
66
614
1.12
0.27
5.5
5.0
0.00
0.00
estimate
0.00
13
120
120
1159
1.13
0.25
4.8
4.0
1.56
1.28
mmol/l
2.29
101
1058
5
39
1.29
0.23
1.2
1.6
—
—
—
0
0
5
40
1.26
0.22
1.8
3.2
—
—
—
0
0
37
336
1.13
0.22
1.7
1.7
1.56
1.34
mmol/l
0.62
30
283
29
259
1.14
0.22
1.6
1.4
2.68
2.39
g/l
0.26
18
156
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
1.34
—
0
6
0
10
0.00
0.21
0.0
8.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
0.96
—
0
7
0
13
0.00
0.21
0.0
1.0
—
293.71
—
0
7
30
320
0.92
0.11
1.3
1.4
—
—
—
0
0
114
1117
1.07
0.10
32.3
15.3
37.35
40.02
%
1.97
67
821
123
1208
1.07
0.10
5.3
4.4
4.50
4.60
mmol/l
0.36
105
1119
12
107
1.13
0.08
1.5
1.9
—
—
—
0
0
59
570
1.05
0.08
12.0
9.7
0.00
0.00
e9/l
0.42
49
467
7
63
1.12
0.08
1.0
1.3
—
—
—
0
0
122
1202
1.06
0.07
5.4
4.4
1.30
1.46
mmol/l
4.54
104
1103
7
83
0.84
0.07
2.4
2.2
—
—
—
0
0
18
168
1.08
0.06
1.3
1.2
—
—
—
0
0
11
100
1.11
0.05
1.4
1.1
—
—
—
0
0
10
91
1.10
0.04
1.0
1.4
—
—
—
0
0
15
157
0.95
0.01
1.7
1.3
373.33
595.56
titre
—
6
36
40
401
1.00
0.00
4.2
4.8
1.97
2.15
ug/l
0.15
30
349
13
126
1.03
0.00
1.6
1.3
—
—
—
0
0
88
877
1.01
0.00
4.2
3.9
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
1950.00
—
0
5
0
5
0.00
0.00
0.0
2.2
—
1.20
—
0
5
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
3.8
—
1.10
—
0
5
0
6
0.00
0.00
0.0
1.8
—
8.17
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
6.3
—
44.50
—
0
6
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
8
83
0.96
0.00
1.3
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H7_VISIMPBILATERAL and mortality.

Females

Parameter HR [95% CI] p-value
H7_VISIMPBILATERAL 2.117 [1.63, 2.75] < 0.001
Birth year 0.993 [0.98, 1.0] 0.088

During the follow-up period (1.1.1998 — 31.12.2019), 416 out of 1022 females with H7_VISIMPBILATERAL died.

Males

Parameter HR [95% CI] p-value
H7_VISIMPBILATERAL 2.19 [1.67, 2.87] < 0.001
Birth year 0.988 [0.98, 1.0] 0.014

During the follow-up period (1.1.1998 — 31.12.2019), 413 out of 986 males with H7_VISIMPBILATERAL died.

Mortality risk

Mortality risk for people of age

years, who have H7_VISIMPBILATERAL.

N-year risk Females Males
1 0.167% 0.477%
5 0.988% 2.345%
10 2.677% 6.198%
15 5.119% 11.656%
20 9.06% 20.056%

Relationships between endpoints

Index endpoint: H7_VISIMPBILATERAL – Blindness or visual impairment, binocular

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
-
0 (0.00)
-
-
-
-
-
-
-
-0.08 [-0.42, 0.26]
-
-
-
-
-
-0.19 [-0.40, 0.01]
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
0.11 [-0.18, 0.40]
-
-
-
-
-
-
-
-
-
0 (0.00)
-
0.06 [-0.23, 0.36]
-
-
-
0 (0.00)
-
-0.05 [-0.33, 0.23]
1
0
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
0.15 [-0.21, 0.51]
12
0
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-0.01 [-0.38, 0.36]
-
-
-
-
-
-
-
-
-
6 (0.07)
-
-
-
-
-
0 (0.00)
-
-0.27 [-0.67, 0.12]
-
-
-
0 (0.00)
-
-0.22 [-0.54, 0.10]
-
-
-
0 (0.00)
-
-0.09 [-0.76, 0.58]
-
-
-
0 (0.00)
-
0.11 [-0.16, 0.39]
-
-
-
-
-
-
-
-
-
50 (0.08)
-
-
-
-
-
-
-
-
-
-
-
-
-
0.18 [-0.15, 0.51]
2
0
-
0 (0.00)
-
0.64 [0.09, 1.18]
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-0.15 [-0.88, 0.57]
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
0.08 [-0.40, 0.55]
4
0
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
-
-
-0.06 [-0.41, 0.29]
1
0
-
-
-
-
-
-
-
0 (0.00)
-
0.11 [-0.41, 0.64]
1
-
-
-
-
-0.14 [-0.39, 0.11]
-
-
-
0 (0.00)
-
-0.24 [-1.57, 1.09]
-
-
-
0 (0.00)
-
0.40 [-0.14, 0.93]
1
0
-
-
-
0.19 [-0.07, 0.45]
-
-
-
14 (0.06)
-
-
-
-
-
0 (0.00)
-
-0.01 [-0.26, 0.23]
-
-
-
-
-
-
-
-
-
9 (0.02)
-
-0.04 [-0.17, 0.09]
79
0
-
-
-
0.06 [-0.20, 0.33]
-
-
-
0 (0.00)
-
0.10 [-0.28, 0.49]
-
-
-
-
-
-0.10 [-0.32, 0.11]
-
-
-
11 (0.03)
-
0.11 [-0.02, 0.25]
35
0
-
0 (0.00)
-
0.08 [-0.29, 0.45]
-
-
-
0 (0.00)
-
-0.14 [-0.57, 0.29]
-
-
-
0 (0.00)
-
0.05 [-0.30, 0.40]
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
0.17 [-0.13, 0.46]
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
0.06 [-0.32, 0.44]
-
-
-
0 (0.00)
-
-
-
-
-
5 (0.07)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
0.17 [-0.33, 0.67]
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-0.18 [-0.44, 0.08]
-
-
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0.29 [-0.36, 0.94]
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23 (0.07)
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0.20 [-0.06, 0.45]
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0.25 [-1.01, 1.51]
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0.04 [-0.33, 0.41]
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0.18 [-0.24, 0.60]
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109 (0.05)
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0.06 [-0.25, 0.37]
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0.02 [-0.30, 0.34]
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0.20 [-0.21, 0.61]
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26 (0.05)
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0.29 [-0.07, 0.64]
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111 (0.05)
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0.09 [-0.20, 0.37]
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0
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85 (0.03)
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0.00 [-0.21, 0.22]
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0.07 [-0.19, 0.33]
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0.14 [-0.13, 0.42]
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27 (0.05)
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0.01 [-0.41, 0.43]
9
0
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0.08 [-0.27, 0.43]
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12 (0.51)
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0.28 [-0.08, 0.64]
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116 (0.04)
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0.11 [-0.12, 0.35]
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0.01 [-0.31, 0.32]
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0.16 [-0.13, 0.45]
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0.14 [-0.37, 0.65]
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0.24 [-0.05, 0.53]
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0.46 [-0.20, 1.13]
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0.03 [-0.28, 0.34]
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0.19 [-0.15, 0.53]
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0.06 [-0.31, 0.43]
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0.10 [-0.17, 0.37]
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0.31 [-0.04, 0.65]
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0.05 [-0.29, 0.40]
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0.17 [-0.18, 0.53]
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15 (0.06)
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0.12 [-0.14, 0.38]
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10 (0.15)
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0.04 [-0.30, 0.37]
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0 (0.00)
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0.05 [-0.17, 0.27]
12
0
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0.02 [-0.28, 0.32]
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16 (0.04)
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0.27 [-0.20, 0.74]
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13 (0.02)
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0.18 [-0.41, 0.77]
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0.02 [-0.27, 0.32]
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12 (0.11)
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0.02 [-0.23, 0.26]
3
0
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0.06 [-0.31, 0.42]
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0.23 [-0.35, 0.81]
1
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0 (0.00)
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0.01 [-0.22, 0.25]
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0
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1
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0
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22 (0.08)
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0.36 [-0.01, 0.74]
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5
0
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0.15 [-0.08, 0.39]
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0.42 [-0.04, 0.89]
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0
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0.08 [-0.18, 0.33]
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0.04 [-0.21, 0.29]
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95 (0.06)
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1
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17 (0.04)
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0 (0.00)
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0 (0.00)
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0.22 [-0.06, 0.50]
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0.01 [-0.21, 0.24]
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87 (0.04)
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0 (0.00)
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0 (0.00)
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0.07 [-0.27, 0.40]
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-0.10 [-0.32, 0.12]
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0 (0.00)
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0 (0.00)
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0.27 [-0.16, 0.70]
1
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0.09 [-0.14, 0.33]
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0 (0.00)
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0.15 [-0.39, 0.70]
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0 (0.00)
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15 (0.02)
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0.18 [-0.26, 0.62]
27
0
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54 (0.08)
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0 (0.00)
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0.37 [0.03, 0.71]
1
0
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0.03 [-0.36, 0.42]
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0 (0.00)
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8 (0.06)
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0.28 [-0.46, 1.03]
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0
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0.05 [-0.15, 0.25]
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0.16 [-0.14, 0.46]
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-0.00 [-0.28, 0.27]
2
0
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0.09 [-0.29, 0.47]
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0
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-0.33 [-0.71, 0.06]
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0.07 [-0.21, 0.35]
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0.29 [-0.02, 0.60]
2
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0 (0.00)
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0.07 [-0.34, 0.48]
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0 (0.00)
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0.09 [-0.24, 0.43]
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0
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0.26 [-0.11, 0.63]
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0.01 [-0.64, 0.67]
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0.10 [-0.60, 0.81]
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0.16 [-0.26, 0.59]
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0.31 [-0.22, 0.84]
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0.18 [-0.08, 0.43]
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0.24 [-0.77, 1.25]
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0.01 [-0.25, 0.26]
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0.12 [-0.07, 0.31]
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0.26 [-0.37, 0.89]
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0.18 [-0.26, 0.63]
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0.22 [-0.01, 0.44]
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0.47 [0.04, 0.90]
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12 (0.10)
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0.16 [-0.36, 0.68]
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22 (0.17)
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13 (0.06)
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0.15 [-0.10, 0.41]
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0.06 [-0.20, 0.33]
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44 (0.06)
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88 (0.04)
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0.54 [0.06, 1.03]
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0.21 [-0.18, 0.61]
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0.24 [-0.22, 0.70]
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36 (0.02)
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24 (0.41)
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0.18 [-0.43, 0.80]
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0.13 [-0.19, 0.44]
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0.04 [-0.21, 0.30]
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0.24 [-0.30, 0.77]
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13 (0.04)
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0.40 [0.11, 0.69]
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16 (0.08)
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0.07 [-0.20, 0.34]
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0.01 [-0.28, 0.29]
10
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0.19 [-0.18, 0.56]
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0.20 [-0.02, 0.42]
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0.03 [-0.28, 0.34]
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47 (0.05)
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0.21 [-0.20, 0.61]
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0.00 [-0.56, 0.56]
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0.13 [-0.21, 0.47]
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-0.04 [-0.20, 0.12]
31
0
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63 (0.09)
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29 (0.16)
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0.09 [-0.21, 0.38]
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0.05 [-0.50, 0.59]
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0.04 [-0.22, 0.29]
1
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0.05 [-0.29, 0.38]
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13 (0.16)
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-0.14 [-0.36, 0.09]
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9 (0.10)
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0.16 [-0.08, 0.39]
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-0.09 [-0.35, 0.17]
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0.23 [-0.21, 0.67]
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0.16 [-0.17, 0.49]
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0.31 [-0.00, 0.62]
23
0
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0.17 [-0.34, 0.67]
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-0.15 [-0.52, 0.22]
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-0.19 [-0.52, 0.13]
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0
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0 (0.00)
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0.01 [-0.21, 0.23]
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0.53 [-0.21, 1.27]
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0
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61 (0.04)
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0 (0.00)
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0.00 [-0.31, 0.31]
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0 (0.00)
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0 (0.00)
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0.20 [-0.14, 0.53]
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0.05 [-0.50, 0.59]
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53 (0.04)
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0 (0.00)
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-0.02 [-0.33, 0.29]
12
0
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-0.11 [-0.38, 0.17]
1
0
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0 (0.00)
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-0.07 [-0.34, 0.20]
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0
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0 (0.00)
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-0.22 [-0.51, 0.07]
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5 (0.02)
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56 (0.05)
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0 (0.00)
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0.23 [-0.16, 0.61]
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19 (0.05)
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0.44 [0.11, 0.78]
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0.08 [-0.14, 0.31]
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0.27 [-0.03, 0.57]
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0.18 [-0.04, 0.40]
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0.25 [-0.27, 0.77]
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0.26 [-0.18, 0.70]
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0.04 [-0.24, 0.32]
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31 (0.21)
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0.08 [-0.13, 0.29]
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0.03 [-0.27, 0.33]
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0.43 [-0.19, 1.04]
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18 (0.10)
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0.01 [-0.21, 0.24]
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0.10 [-0.18, 0.38]
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0.08 [-0.30, 0.46]
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81 (0.06)
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0.13 [-0.08, 0.34]
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0.25 [-0.12, 0.62]
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0.20 [-0.02, 0.42]
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0.14 [-0.20, 0.48]
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164 (0.07)
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0.23 [-0.13, 0.59]
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0.03 [-0.18, 0.24]
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0.04 [-0.32, 0.40]
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0.30 [-0.29, 0.89]
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0.35 [0.02, 0.68]
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0.28 [-0.08, 0.64]
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3
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19 (0.03)
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16 (0.07)
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0.35 [0.12, 0.57]
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0.36 [0.11, 0.62]
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0.02 [-0.20, 0.25]
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106 (0.04)
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0.28 [-0.19, 0.76]
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0.02 [-0.16, 0.20]
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0.24 [-0.23, 0.71]
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19 (0.09)
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0.09 [-0.14, 0.33]
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0.05 [-0.28, 0.39]
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0.17 [-0.61, 0.94]
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30 (0.02)
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0.06 [-0.20, 0.31]
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10 (0.14)
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0.14 [-0.06, 0.33]
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0
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0.06 [-0.27, 0.39]
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-0.17 [-0.40, 0.07]
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-0.06 [-0.40, 0.27]
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0.19 [-0.15, 0.52]
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0.12 [-0.06, 0.30]
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0.14 [-0.18, 0.47]
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0.05 [-0.35, 0.44]
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0.24 [-0.10, 0.58]
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0.28 [0.01, 0.56]
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-0.05 [-0.35, 0.25]
10
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-0.23 [-0.53, 0.08]
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-0.03 [-0.27, 0.20]
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3
0
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15 (0.07)
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0.25 [-0.12, 0.62]
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0 (0.00)
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0.27 [-0.02, 0.55]
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0 (0.00)
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0
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0.09 [-0.19, 0.36]
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106 (0.04)
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0.26 [0.07, 0.46]
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0 (0.00)
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0.38 [-0.05, 0.80]
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0 (0.00)
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0.03 [-0.19, 0.25]
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-0.09 [-0.75, 0.56]
1
0
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0 (0.00)
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0.14 [-0.11, 0.40]
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0 (0.00)
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0.16 [-0.09, 0.41]
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0.08 [-0.40, 0.55]
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0
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14 (0.06)
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0.37 [0.10, 0.63]
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0 (0.00)
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22 (0.07)
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0 (0.00)
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0.00 [-0.40, 0.41]
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11 (0.07)
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0.07 [-0.09, 0.23]
4
0
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15 (0.17)
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-0.05 [-0.44, 0.34]
1
0
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0 (0.00)
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0.04 [-0.29, 0.38]
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-0.02 [-0.23, 0.19]
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0 (0.00)
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0.16 [-0.04, 0.36]
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0.06 [-0.35, 0.48]
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0.11 [-0.26, 0.48]
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47 (0.74)
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0.04 [-0.49, 0.56]
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0.08 [-0.32, 0.49]
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23 (0.37)
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0
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0.72 [-0.65, 2.10]
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0.01 [-0.61, 0.63]
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0.13 [-0.22, 0.47]
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5 (0.07)
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-0.25 [-0.92, 0.41]
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211 (3.12)
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0.39 [0.11, 0.68]
13
0
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-0.25 [-0.71, 0.20]
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0
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0
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63 (0.91)
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0.02 [-0.58, 0.62]
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0
11 (0.16)
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-0.00 [-0.57, 0.57]
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16 (0.23)
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0.07 [-0.32, 0.45]
3
0
15 (0.21)
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0.49 [-0.18, 1.17]
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8 (0.11)
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0.05 [-0.26, 0.36]
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9 (0.13)
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-0.14 [-0.53, 0.24]
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5 (0.07)
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0.12 [-0.37, 0.61]
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7 (0.10)
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6 (0.08)
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0.03 [-0.23, 0.29]
7
0
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0.30 [-0.09, 0.68]
1
0
68 (0.93)
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0.04 [-0.33, 0.42]
1
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7 (0.10)
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0.31 [-0.09, 0.71]
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0
54 (0.74)
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0.17 [-0.09, 0.43]
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0.01 [-0.41, 0.42]
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0
28 (0.38)
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1
0
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0
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11 (0.14)
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-0.01 [-0.34, 0.32]
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0
6 (0.08)
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0.12 [-0.25, 0.49]
1
0
9 (0.12)
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0.37 [-0.03, 0.78]
2
0
186 (2.42)
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0.16 [-0.37, 0.69]
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-0.24 [-0.79, 0.32]
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27 (0.35)
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0.12 [-0.24, 0.47]
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15 (0.19)
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-0.04 [-0.40, 0.31]
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30 (0.37)
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-0.11 [-0.58, 0.36]
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-0.06 [-0.38, 0.25]
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0
11 (0.14)
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0.08 [-0.36, 0.51]
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0
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0.34 [0.01, 0.66]
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8 (0.10)
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0.31 [-0.09, 0.70]
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0
14 (0.17)
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0.15 [-0.19, 0.50]
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56 (0.68)
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0.03 [-0.52, 0.57]
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15 (0.18)
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0.14 [-0.81, 1.08]
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53 (0.64)
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0.01 [-0.50, 0.51]
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1
0
5 (0.06)
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0.04 [-0.48, 0.56]
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31 (0.37)
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-0.10 [-0.45, 0.24]
1
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16 (0.19)
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-0.13 [-0.48, 0.22]
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0
12 (0.14)
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0.14 [-0.50, 0.79]
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12 (0.14)
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-0.09 [-0.38, 0.20]
20
0
11 (0.13)
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0.14 [-0.31, 0.58]
2
0
39 (0.45)
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-0.06 [-0.88, 0.75]
1
0
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0.14 [-0.59, 0.86]
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5 (0.06)
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17 (0.19)
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20 (0.23)
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-0.07 [-0.67, 0.54]
1
0
13 (0.15)
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0
13 (0.15)
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0.35 [-0.53, 1.23]
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6 (0.07)
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0.05 [-0.34, 0.44]
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0
8 (0.09)
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0.72 [-5.39, 6.82]
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5 (0.06)
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48 (0.53)
11 (0.53)
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0
38 (0.44)
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2
0
48 (0.53)
5 (0.54)
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5 (0.05)
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0
8 (0.09)
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0.26 [-0.12, 0.63]
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0
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0.00 [-0.36, 0.37]
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0.30 [-0.19, 0.80]
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0
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0
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0
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0.50 [-2.48, 3.47]
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0.09 [-0.52, 0.70]
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132 (0.71)
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0.18 [-0.38, 0.75]
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0.54 [0.10, 0.99]
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0.34 [-0.29, 0.97]
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0.19 [-0.09, 0.47]
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7
0
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0.24 [-0.04, 0.53]
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17 (0.09)
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0.08 [-0.63, 0.79]
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0.05 [-0.27, 0.37]
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0.21 [-0.05, 0.48]
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0.16 [-0.14, 0.46]
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0.03 [-0.24, 0.30]
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0.03 [-0.22, 0.28]
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0.12 [-0.07, 0.31]
22
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0.18 [-0.06, 0.43]
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0
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0.05 [-0.27, 0.36]
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0.09 [-0.17, 0.34]
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0
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0.27 [-0.16, 0.70]
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0.05 [-0.36, 0.46]
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0
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0.37 [-0.12, 0.85]
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0
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0
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0.20 [-0.11, 0.51]
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19 (0.10)
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1
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17 (0.08)
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0.02 [-0.44, 0.47]
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0.06 [-0.25, 0.38]
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0.11 [-0.14, 0.37]
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0
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11 (0.05)
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0.05 [-0.26, 0.36]
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0
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0.30 [-0.03, 0.63]
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30 (0.15)
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0.10 [-0.29, 0.50]
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18 (0.09)
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0.02 [-0.37, 0.40]
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0.15 [-0.26, 0.57]
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0
10 (0.05)
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0.15 [-0.12, 0.41]
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282 (1.40)
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0.08 [-0.22, 0.38]
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0
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33 (0.16)
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0.26 [-0.40, 0.91]
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14 (0.07)
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0.34 [0.03, 0.65]
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0
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0.07 [-0.19, 0.34]
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0
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0.21 [-0.05, 0.47]
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0
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15 (0.07)
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0.00 [-0.35, 0.36]
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0
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11 (0.05)
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13
0
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0.01 [-0.47, 0.48]
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0
11 (0.05)
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70 (0.33)
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0
9 (0.04)
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0.23 [-0.62, 1.07]
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16 (0.08)
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0.10 [-0.48, 0.68]
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0
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1.00 [-1.88, 3.88]
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0
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0.11 [-0.24, 0.45]
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6 (0.03)
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0.03 [-0.20, 0.27]
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0
38 (0.18)
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0.14 [-0.18, 0.46]
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0
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0.06 [-0.30, 0.42]
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0
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18
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0
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0.21 [-0.09, 0.51]
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0
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0 (0.00)
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0.05 [-0.12, 0.22]
14
0
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0.30 [-0.34, 0.93]
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47 (0.22)
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0.17 [-0.55, 0.88]
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0
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8 (0.04)
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0.32 [0.01, 0.63]
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0
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0.15 [-0.26, 0.55]
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0
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0.25 [-0.10, 0.61]
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23 (0.10)
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14
0
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0.09 [-0.21, 0.40]
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0.21 [-0.03, 0.45]
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14 (0.06)
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1
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0.06 [-0.41, 0.54]
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0
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27
0
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0.13 [-0.09, 0.35]
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0
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0.19 [-0.29, 0.66]
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0.08 [-0.31, 0.47]
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0
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0.37 [-0.25, 0.99]
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36 (0.16)
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44 (0.19)
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12 (0.05)
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0.35 [-0.14, 0.83]
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0
22 (0.09)
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0.02 [-0.47, 0.52]
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49 (0.21)
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0.23 [-0.14, 0.59]
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0.14 [-0.79, 1.06]
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0.37 [-0.11, 0.85]
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0
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29 (0.12)
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0.28 [-0.03, 0.58]
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8
0
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0
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0.13 [-0.23, 0.48]
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0
18 (0.08)
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0.02 [-0.16, 0.19]
25
0
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39 (0.16)
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0.20 [-0.12, 0.52]
9
0
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22
0
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0.32 [-0.13, 0.76]
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0.16 [-0.18, 0.49]
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30 (0.12)
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0
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10
0
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40
0
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8
0
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0.17 [-0.13, 0.47]
18
0
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0.19 [-0.11, 0.49]
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0
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0
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-0.33 [-0.97, 0.32]
1
0
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0.09 [-0.22, 0.40]
2
0
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0.16 [-0.14, 0.45]
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0
49 (0.20)
11 (0.30)
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-0.09 [-0.35, 0.18]
1
0
13 (0.05)
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0.03 [-0.25, 0.30]
8
0
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0
10 (0.04)
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0.06 [-0.33, 0.44]
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9 (0.04)
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-0.30 [-0.62, 0.02]
8
0
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0.19 [-0.01, 0.38]
18
0
16 (0.06)
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-0.65 [-1.33, 0.02]
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11 (0.04)
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21
0
18 (0.07)
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0.06 [-0.26, 0.38]
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0.29 [-0.11, 0.69]
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0
30 (0.12)
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1
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25 (0.10)
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0.13 [-0.23, 0.49]
1
0
10 (0.04)
0 (0.00)
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0.04 [-0.29, 0.37]
6
0
90 (0.35)
11 (0.32)
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0.47 [-0.06, 0.99]
2
0
7 (0.03)
0 (0.00)
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-0.05 [-0.23, 0.14]
29
0
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0 (0.00)
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0.01 [-0.20, 0.22]
9
0
11 (0.04)
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-0.06 [-0.39, 0.26]
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0
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19 (0.07)
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0.24 [-0.13, 0.61]
1
0
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0.16 [-0.12, 0.43]
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0
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0.42 [0.15, 0.68]
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9 (0.03)
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0.04 [-0.16, 0.24]
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0
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0
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23 (0.09)
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-0.50 [-1.10, 0.10]
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0
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0.15 [-0.16, 0.45]
8
0
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1
0
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0.01 [-0.15, 0.18]
24
0
13 (0.05)
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0.51 [-1.10, 2.12]
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15 (0.06)
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0
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0.18 [-0.11, 0.48]
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0
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0.27 [-0.04, 0.58]
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0
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8 (0.03)
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16
0
16 (0.06)
0 (0.00)
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0
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0.10 [-0.15, 0.34]
6
0
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8 (0.03)
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12 (0.04)
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0
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0.19 [-0.21, 0.59]
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0
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0.11 [-0.08, 0.29]
30
0
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-0.02 [-0.38, 0.35]
1
0
32 (0.12)
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0.07 [-0.47, 0.60]
1
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37 (0.13)
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0.19 [-0.23, 0.60]
1
0
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-0.17 [-0.41, 0.08]
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0
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0 (0.00)
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8 (0.03)
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37 (0.13)
5 (0.10)
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-0.20 [-1.04, 0.64]
1
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18 (0.06)
0 (0.00)
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0
23 (0.08)
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0.25 [-0.27, 0.77]
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18 (0.06)
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0.07 [-0.14, 0.29]
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0
28 (0.10)
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0.10 [-0.22, 0.42]
5
0
8 (0.03)
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0.17 [-0.15, 0.50]
1
0
2294 (8.80)
164 (6.14)
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0.80 [-1.68, 3.27]
2
0
22 (0.08)
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0.10 [-0.28, 0.48]
1
0
24 (0.08)
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0.14 [-0.35, 0.62]
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13 (0.05)
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0.18 [-0.08, 0.45]
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22 (0.08)
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-
68 (0.24)
7 (0.20)
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0.08 [-0.17, 0.32]
4
0
20 (0.07)
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0.11 [-0.17, 0.38]
1
0
12 (0.04)
0 (0.00)
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0.02 [-0.25, 0.29]
6
0
15 (0.05)
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0.10 [-0.17, 0.37]
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7 (0.02)
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0.43 [0.11, 0.74]
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28 (0.10)
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0.21 [-0.03, 0.45]
14
0
15 (0.05)
0 (0.00)
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-0.28 [-0.61, 0.05]
2
0
47 (0.16)
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-0.08 [-0.56, 0.41]
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21 (0.07)
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-0.03 [-0.36, 0.29]
1
0
12 (0.04)
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0.13 [-0.13, 0.39]
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14 (0.05)
5 (0.07)
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10
0
17 (0.06)
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0.58 [0.03, 1.14]
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0
22 (0.08)
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0.09 [-0.48, 0.66]
1
0
15 (0.05)
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-0.15 [-0.55, 0.26]
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-
18 (0.06)
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-0.22 [-0.61, 0.17]
1
0
258 (0.89)
19 (0.69)
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0.10 [-0.15, 0.36]
4
0
29 (0.10)
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0.10 [-0.20, 0.39]
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0
26 (0.09)
5 (0.15)
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-
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-
113 (0.38)
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-0.03 [-0.30, 0.24]
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-
306 (1.04)
27 (0.67)
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-0.04 [-0.37, 0.28]
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-
15 (0.05)
0 (0.00)
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-
-
-
148 (0.50)
15 (0.38)
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-0.08 [-0.39, 0.22]
8
0
23 (0.08)
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-
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16 (0.05)
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0.94 [-4.36, 6.24]
1
0
27 (0.09)
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0.00 [-0.31, 0.31]
1
0
12 (0.04)
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0.17 [-0.24, 0.58]
1
0
99 (0.33)
16 (0.39)
-
0.13 [-0.27, 0.53]
1
0
14 (0.05)
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-
0.05 [-0.27, 0.37]
1
-
64 (0.21)
-
-
0.02 [-0.21, 0.24]
3
0
10 (0.03)
0 (0.00)
-
0.11 [-0.28, 0.49]
4
0
16 (0.05)
-
-
-
-
-
15 (0.05)
-
-
0.29 [-0.10, 0.69]
1
0
45 (0.15)
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0.19 [-0.51, 0.88]
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61 (0.18)
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0.32 [-0.25, 0.88]
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0.09 [-0.15, 0.33]
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0.58 [-0.17, 1.33]
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0.06 [-0.52, 0.65]
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0.04 [-0.44, 0.52]
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31 (0.09)
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0.11 [-0.26, 0.47]
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0.10 [-0.21, 0.41]
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0.02 [-0.18, 0.23]
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0.18 [-0.21, 0.56]
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0.23 [-0.14, 0.59]
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0.01 [-0.34, 0.36]
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0.72 [-0.06, 1.50]
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0.13 [-0.13, 0.39]
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0.48 [-0.17, 1.13]
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0
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0.02 [-0.17, 0.21]
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0.22 [-0.20, 0.64]
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16
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80 (0.17)
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0.06 [-0.29, 0.40]
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38 (0.07)
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0.21 [-0.21, 0.64]
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76 (0.15)
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0.18 [-0.09, 0.46]
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0
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0.14 [-0.13, 0.40]
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0.13 [-0.03, 0.29]
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0.07 [-0.15, 0.30]
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0.07 [-0.14, 0.29]
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0.02 [-0.22, 0.25]
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50 (0.09)
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0.12 [-0.15, 0.39]
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34 (0.06)
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0.13 [-0.22, 0.49]
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0.04 [-0.18, 0.25]
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0.04 [-0.32, 0.40]
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39 (0.07)
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0.05 [-0.26, 0.35]
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0
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0.24 [-0.02, 0.50]
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0
18 (0.03)
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10
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255 (0.05)
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33
0
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0.12 [-0.05, 0.28]
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0
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0
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0.06 [-0.07, 0.20]
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0
509 (0.04)
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0.10 [-0.06, 0.27]
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0
843 (0.06)
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0.10 [-0.02, 0.22]
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128 (0.05)
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0.06 [-0.20, 0.33]
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0.00 [-0.16, 0.17]
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0
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0.20 [0.00, 0.40]
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0
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0.24 [-0.07, 0.54]
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86 (0.05)
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0.05 [-0.09, 0.19]
10
0
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0.51 [0.22, 0.79]
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0
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0.17 [-0.01, 0.35]
21
0
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0.14 [0.01, 0.27]
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0
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0
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0.14 [-0.20, 0.48]
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0.16 [-0.47, 0.78]
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37 (0.02)
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0.05 [-0.11, 0.22]
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0
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0.10 [-0.06, 0.26]
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0
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0
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0
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0.18 [-0.02, 0.38]
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0
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0.10 [-0.09, 0.28]
15
0
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0.04 [-0.08, 0.17]
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0
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0.01 [-0.11, 0.13]
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0
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0.01 [-0.13, 0.16]
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0
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0.00 [-0.13, 0.13]
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0
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5
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222 (0.08)
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29 (0.09)
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0.01 [-0.18, 0.21]
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0
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0.14 [-0.01, 0.29]
20
0
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0.03 [-0.24, 0.31]
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0
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0.03 [-0.14, 0.19]
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0
172 (0.06)
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0.06 [-0.06, 0.19]
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0
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180 (0.06)
27 (0.05)
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4
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73 (0.02)
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0.03 [-0.13, 0.18]
7
0
137 (0.04)
27 (0.04)
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0.05 [-0.06, 0.16]
45
0
413 (0.12)
38 (0.10)
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0.16 [-0.06, 0.39]
1
0
360 (0.11)
37 (0.08)
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0.02 [-0.16, 0.21]
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0
183 (0.05)
20 (0.05)
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0.03 [-0.13, 0.20]
5
0
224 (0.07)
23 (0.05)
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0.10 [-0.04, 0.25]
33
0
1056 (0.31)
83 (0.18)
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0.06 [-0.10, 0.22]
12
0
366 (0.11)
35 (0.08)
-
-0.11 [-0.27, 0.06]
47
0
76 (0.02)
-
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0.00 [-0.30, 0.31]
2
0
181 (0.05)
28 (0.07)
-
0.06 [-0.08, 0.21]
13
0
172 (0.05)
24 (0.05)
-
0.11 [-0.02, 0.24]
28
0
107 (0.03)
10 (0.05)
-
-0.02 [-0.18, 0.14]
2
0
179 (0.05)
18 (0.05)
-
-0.13 [-0.25, -0.02]
212
0
78 (0.02)
10 (0.02)
-
0.05 [-0.10, 0.20]
37
0
325 (0.08)
17 (0.08)
-
-
-
-
400 (0.10)
29 (0.08)
-
-
60
-
244 (0.06)
23 (0.07)
-
-
-
-
425 (0.10)
39 (0.08)
-
0.09 [-0.06, 0.25]
12
0
170 (0.04)
11 (0.02)
-
-0.03 [-0.16, 0.09]
125
0
104 (0.03)
9 (0.02)
-
0.07 [-0.07, 0.20]
6
0
242 (0.06)
26 (0.05)
-
0.00 [-0.11, 0.11]
235
0
351 (0.08)
19 (0.07)
-
0.08 [-0.13, 0.29]
40
0
317 (0.07)
32 (0.07)
-
-0.04 [-0.17, 0.09]
102
0
452 (0.10)
38 (0.11)
-
0.15 [-0.05, 0.35]
10
0
242 (0.05)
7 (0.03)
-
-0.06 [-0.29, 0.17]
5
0
238 (0.05)
22 (0.03)
-
-0.03 [-0.15, 0.08]
111
0
337 (0.07)
29 (0.07)
-
-0.06 [-0.26, 0.14]
3
0
477 (0.10)
35 (0.07)
-
0.08 [-0.08, 0.25]
1
0
198 (0.04)
9 (0.02)
-
-
-
-
444 (0.09)
32 (0.08)
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0.25 [0.10, 0.40]
15
0
500 (0.10)
47 (0.07)
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-0.10 [-0.26, 0.07]
41
0
363 (0.07)
21 (0.03)
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0.05 [-0.12, 0.22]
5
0
327 (0.06)
-
-
0.10 [-0.03, 0.23]
40
0
333 (0.06)
45 (0.08)
-
-
-
-
587 (0.11)
52 (0.09)
-
0.08 [-0.14, 0.30]
2
0
261 (0.05)
14 (0.02)
-
-
-
-
550 (0.10)
46 (0.07)
-
0.25 [0.07, 0.44]
4
0
370 (0.07)
39 (0.05)
-
-0.00 [-0.12, 0.11]
172
0
544 (0.09)
48 (0.07)
-
0.03 [-0.13, 0.19]
80
0
299 (0.05)
29 (0.04)
-
-0.12 [-0.24, -0.00]
193
0
597 (0.10)
59 (0.07)
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0.04 [-0.13, 0.20]
54
0
592 (0.10)
50 (0.09)
-
0.11 [-0.05, 0.27]
17
0
450 (0.07)
45 (0.06)
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-0.06 [-0.20, 0.09]
4
0
294 (0.05)
41 (0.05)
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0.12 [0.00, 0.25]
72
0
173 (0.03)
18 (0.03)
-
0.08 [-0.06, 0.22]
88
0
378 (0.06)
31 (0.04)
-
0.04 [-0.09, 0.16]
115
0
323 (0.05)
15 (0.04)
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-0.06 [-0.25, 0.13]
17
0
546 (0.08)
37 (0.06)
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0.04 [-0.08, 0.17]
147
0
357 (0.05)
29 (0.03)
-
0.01 [-0.09, 0.12]
350
0
366 (0.05)
22 (0.04)
-
0.03 [-0.15, 0.21]
4
0
488 (0.07)
29 (0.05)
-
0.03 [-0.10, 0.15]
105
0
398 (0.05)
33 (0.03)
-
-0.02 [-0.13, 0.09]
104
0
513 (0.06)
44 (0.05)
-
0.14 [0.03, 0.26]
107
0
449 (0.05)
52 (0.05)
-
-
-
-
370 (0.04)
38 (0.03)
-
0.07 [-0.05, 0.18]
60
0
333 (0.04)
35 (0.03)
-
0.05 [-0.07, 0.17]
37
0
770 (0.08)
72 (0.06)
-
0.13 [-0.00, 0.26]
29
0
800 (0.08)
74 (0.06)
-
0.02 [-0.09, 0.14]
207
0
893 (0.09)
63 (0.07)
-
0.26 [0.08, 0.43]
7
0
684 (0.07)
47 (0.05)
-
0.03 [-0.09, 0.16]
131
0
287 (0.03)
41 (0.03)
-
-
5
-
594 (0.06)
36 (0.04)
-
-0.07 [-0.25, 0.11]
3
0
450 (0.04)
50 (0.03)
-
0.09 [-0.04, 0.21]
27
0
474 (0.04)
51 (0.03)
-
0.12 [-0.03, 0.27]
10
0
441 (0.04)
58 (0.04)
-
-
1
-
893 (0.08)
79 (0.06)
-
0.05 [-0.05, 0.15]
327
0
638 (0.05)
54 (0.04)
-
0.09 [-0.02, 0.21]
62
0
816 (0.06)
97 (0.05)
-
0.02 [-0.08, 0.13]
300
0
1015 (0.07)
89 (0.06)
-
0.06 [-0.03, 0.16]
392
0
746 (0.05)
71 (0.04)
-
0.03 [-0.09, 0.15]
64
0
979 (0.05)
-
-
0.11 [-0.00, 0.23]
72
0
1596 (0.04)
148 (0.03)
-
0.04 [-0.09, 0.16]
33
0