No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
164 |
4. Check minimum number of eventsNone |
164 |
5. Include endpointsNone |
164 |
6. Filter based on genotype QC (FinnGen only) |
164 |
Control definitions (FinnGen only)
- Control exclude
- H7_VISUALDISTBLIND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H54
- Name in latin
- Amaurosis oculorum amborum
Similar endpoints
↥List of similar endpoints to
Blindness or visual impairment, binocular
based on the number of shared cases.
Similar with more cases:
- Visual impairment including blindness (binocular or monocular)
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2294 | 1145 | 1123 |
| Only index persons | 1910 | 996 | 914 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 62.61 | 64.75 | 60.11 |
| Only index persons | 61.83 | 64.18 | 59.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 164 | 87 | 77 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 56.94 | 52.90 | 61.49 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 146
- Matched controls
- 1457
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H54.0
ICD-10 Finland
Blindness, binocular
+∞
211.0
146
*
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
321.6
46.9
45
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
119.6
27.8
29
*
S01EC01
ATC
acetazolamide; systemic
37.2
20.0
25
8
S01ED01
ATC
timolol; ophthalmic
15.4
18.7
31
25
H54.1
ICD-10 Finland
Severe visual impairment, binocular
+∞
17.0
16
*
AA1AD
NOMESCO Finland
CT of head and brain
5.1
16.4
64
195
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
+∞
15.9
15
*
F94
ICPC
Blindness
+∞
15.9
15
*
R3120
NOMESCO Finland
Training in mobility skills
178.2
15.8
16
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
23.2
15.7
22
11
114
Kela drug reimbursment
Glaucoma
7.4
15.1
38
66
H54.4
ICD-10 Finland
Blindness, monocular
165.8
14.7
15
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.4
14.2
48
122
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
7.9
14.0
33
52
S01ED51
ATC
timolol, combinations; ophthalmic
7.7
13.4
32
51
A10AA02
ATC
NA
10.8
12.6
24
26
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
5.9
12.5
37
79
CKD40
NOMESCO Finland
Endophotocoagulation of retina
29.6
12.3
16
6
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
10.4
12.3
24
27
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.4
12.1
39
92
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
14.3
12.0
20
16
A28
ICPC
Limited function/disability NOS
4.7
11.7
44
123
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
+∞
11.6
11
*
H54.7
ICD-10 Finland
Unspecified visual loss
129.7
11.6
12
*
A10AA01
ATC
NA
11.5
11.4
21
21
H04AA01
ATC
glucagon; nasal, parenteral
15.6
11.3
18
13
H33.0
ICD-10 Finland
Retinal detachment with retinal break
17.3
11.1
17
11
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
10.8
10.7
20
21
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
25.6
10.5
14
6
H53.1
ICD-10 Finland
Subjective visual disturbances
21.9
10.0
14
7
XCK00
NOMESCO Finland
Perimetry
7.6
9.9
23
35
37520
ICD-8 Finland
Glaucoma, Secondary
106.6
9.5
10
*
H33.4
ICD-10 Finland
Traction detachment of retina
106.6
9.5
10
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
23.6
9.5
13
6
H3603, E103
ICD-10 Finland
NA
23.6
9.5
13
6
H44.5
ICD-10 Finland
Degenerated conditions of globe
+∞
9.5
9
*
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
+∞
9.5
9
*
H53.4
ICD-10 Finland
Visual field defects
+∞
9.5
9
*
127
Kela drug reimbursment
Transplant complication
20.2
9.1
13
7
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
5.1
9.1
29
67
XCK10
NOMESCO Finland
Photography of fundus of eye
5.0
9.1
30
72
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
25.9
9.1
12
5
S01EE01
ATC
latanoprost; ophthalmic
6.0
8.8
24
46
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
53.2
8.8
10
*
S01FA01
ATC
atropine; ophthalmic
53.2
8.8
10
*
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
5.2
8.6
27
61
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
21.6
8.6
12
6
Z49.1
ICD-10 Finland
Extracorporeal dialysis
21.6
8.6
12
6
CKD15
NOMESCO Finland
Injection of vitreous substitute
95.3
8.5
9
*
3690A
ICD-9 Finland
Blindness and low vision, Profound impairment, both eyes
+∞
8.4
8
*
Z02.4
ICD-10 Finland
Examination for driving licence
0.0
8.3
*
193
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
35.5
8.2
10
*
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
23.6
8.1
11
5
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.7
8.1
38
127
SPAT1231
SPAT
Assessment of adjustments needed in living environment
14.1
8.0
13
10
H16.0
ICD-10 Finland
Corneal ulcer
7.1
8.0
19
30
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.7
8.0
37
122
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.8
7.9
72
379
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
47.5
7.8
9
*
TK800
NOMESCO Finland
Hemodialysis
12.8
7.7
13
11
V03AE01
ATC
polystyrene sulfonate; oral
19.6
7.7
11
6
Z94.0
ICD-10 Finland
Kidney transplant status
19.6
7.7
11
6
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
19.6
7.7
11
6
H43.1
ICD-10 Finland
Vitreous haemorrhage
10.9
7.7
14
14
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.9
7.7
25
59
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
26.6
7.7
10
*
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
9.1
7.5
15
18
H54.3
ICD-10 Finland
Mild or no visual impairment, binocular
84.1
7.5
8
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
84.1
7.5
8
*
N03AX09
ATC
lamotrigine; oral
10.2
7.5
14
15
XCD10
NOMESCO Finland
Electrophysiological examination of eye
11.7
7.5
13
12
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
8.0
7.4
16
22
H47.2
ICD-10 Finland
Optic atrophy
+∞
7.3
7
*
S01EX03
ATC
NA
12.9
7.2
12
10
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.7
7.2
32
102
N05AH04
ATC
quetiapine; oral
3.6
7.2
34
114
S01BC03
ATC
diclofenac; ophthalmic
9.0
7.0
14
17
L28
ICPC
Limited function/disability (L)
3.4
7.0
35
123
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
6.9
73
410
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
6.5
6.8
17
29
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
5.3
6.8
20
42
L04AA01
ATC
[U] ciclosporin; systemic
17.7
6.8
10
6
H26.2
ICD-10 Finland
Complicated cataract
17.7
6.8
10
6
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
9.4
6.7
13
15
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
13.1
6.7
11
9
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
10.8
6.7
12
12
A11CC03
ATC
alfacalcidol; systemic
10.8
6.7
12
12
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
10.8
6.7
12
12
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
8.0
6.6
14
19
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.1
6.5
25
70
H46
ICD-10 Finland
Optic neuritis
72.9
6.5
7
*
2504B
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYYPPI I]
72.9
6.5
7
*
N05AX08
ATC
risperidone; systemic
4.5
6.4
22
55
S01EC04
ATC
brinzolamide; ophthalmic
6.8
6.4
15
24
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
19.0
6.3
9
5
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
19.0
6.3
9
5
E10
ICD-10 Finland
Type 1 diabetes mellitus
19.0
6.3
9
5
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
19.0
6.3
9
5
SPAT1229
SPAT
Assessment of need for aid
4.4
6.3
22
56
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
+∞
6.3
6
*
74483
ICD-8 Finland
Congenital anomalies of eye, Retinitis pigmentosa
+∞
6.3
6
*
37909
ICD-8 Finland
Blindness, both eyes, specifically defined
+∞
6.3
6
*
N06AX11
ATC
mirtazapine; oral
2.6
6.2
56
282
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.7
6.0
49
233
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
76
362
3.05
11.01
3.1
2.0
291.6
214.6
u/l
0.25
71
340
47
168
3.52
11.01
12.0
6.0
1.1
1.1
mmol/l
0.48
41
151
30
91
3.81
8.85
7.4
4.3
111.2
75.7
ng/l
0.93
24
82
90
548
2.42
7.15
13.6
6.1
1.2
1.2
mmol/l
0.05
76
506
45
205
2.65
6.60
2.3
2.0
—
—
—
0
0
47
229
2.47
5.94
2.0
1.7
1140.9
1215.0
nmol/l
0.20
35
183
84
531
2.19
5.72
8.8
4.7
33.9
35.7
g/l
1.74
68
498
105
736
2.18
5.37
11.6
4.5
7.4
6.8
mmol/l
1.58
100
682
17
49
3.75
5.33
2.7
1.9
—
—
—
0
0
23
82
3.10
5.23
9.4
4.0
5.4
5.1
kpa
0.91
23
75
90
600
2.11
5.18
16.2
7.1
1.2
1.2
mmol/l
0.50
72
505
17
52
3.53
4.89
3.0
2.2
—
—
—
0
0
19
63
3.28
4.85
1.9
1.8
—
—
—
0
0
25
102
2.71
4.47
2.8
2.7
10.0
6.3
ug/l
0.35
16
91
0
109
0.00
4.39
0.0
1.8
—
—
—
0
0
30
138
2.44
4.21
1.6
1.8
—
—
—
0
0
14
42
3.55
4.14
1.4
1.3
—
—
—
0
0
125
985
2.13
4.13
11.1
7.2
86.6
77.0
u/l
1.57
111
921
22
88
2.73
4.08
1.8
1.6
—
—
—
0
0
7
7
10.37
4.05
7.3
3.1
—
—
—
0
0
29
134
2.41
4.03
11.2
8.2
—
—
—
0
0
95
686
1.91
3.98
7.5
6.1
9.5
11.4
umol/l
1.98
84
651
75
508
1.88
3.77
5.6
3.9
152.5
33.4
ng/l
0.57
59
358
30
146
2.29
3.71
5.2
4.4
32.6
31.9
%
0.11
21
98
74
503
1.86
3.65
3.3
2.4
75.4
76.2
nmol/l
0.09
65
453
29
140
2.30
3.65
2.6
3.8
4.5
9.1
umol/l
2.08
20
121
71
480
1.84
3.54
2.4
2.0
105.9
97.4
pmol/l
0.66
39
263
10
30
3.48
2.95
1.5
1.4
—
—
—
0
0
10
30
3.48
2.95
1.5
1.4
—
—
—
0
0
27
140
2.11
2.85
1.7
1.9
—
—
—
0
0
5
6
8.54
2.76
1.6
2.0
—
—
—
0
0
5
6
8.54
2.76
1.6
2.0
—
—
—
0
0
5
6
8.54
2.76
1.8
1.0
—
—
—
0
0
5
7
7.32
2.56
1.2
2.1
—
—
—
0
0
5
7
7.32
2.56
1.6
2.0
—
—
—
0
0
5
7
7.32
2.56
1.2
2.1
—
—
—
0
0
5
7
7.32
2.56
1.4
2.1
—
—
—
0
0
5
7
7.32
2.56
1.6
2.0
—
—
—
0
0
8
21
3.95
2.49
1.8
1.5
—
—
—
0
0
11
40
2.87
2.42
1.5
1.2
—
—
—
0
0
37
227
1.81
2.42
3.6
3.9
33.5
147.6
ng/l
1.36
27
180
5
8
6.40
2.38
1.2
2.0
—
—
—
0
0
5
8
6.40
2.38
1.2
2.0
—
—
—
0
0
5
8
6.40
2.38
1.2
2.0
—
—
—
0
0
5
8
6.40
2.38
1.2
2.0
—
—
—
0
0
25
135
2.00
2.38
3.4
3.4
—
—
—
0
0
45
295
1.72
2.35
2.9
2.1
3.4
3.2
mg/l
0.30
36
259
59
417
1.65
2.32
5.6
3.7
2.4
2.4
mmol/l
0.03
47
363
43
280
1.72
2.29
1.6
1.7
417.2
426.4
pmol/l
0.07
36
239
7
18
4.01
2.27
1.1
1.9
—
—
—
0
0
15
67
2.36
2.25
9.9
4.6
22.6
24.6
mmol/l
2.24
15
60
46
309
1.68
2.19
1.6
1.6
21.1
20.8
nmol/l
0.04
39
263
8
26
3.18
2.04
1.9
1.7
—
—
—
0
0
7
21
3.43
1.98
1.1
1.8
—
—
—
0
0
6
16
3.85
1.95
2.0
1.9
—
—
—
0
0
6
16
3.85
1.95
2.0
1.9
—
—
—
0
0
6
16
3.85
1.95
2.0
1.9
—
—
—
0
0
6
16
3.85
1.95
2.0
1.9
—
—
—
0
0
6
16
3.85
1.95
2.0
1.9
—
—
—
0
0
6
16
3.85
1.95
2.0
1.9
—
—
—
0
0
11
46
2.49
1.89
1.4
1.2
—
—
—
0
0
9
35
2.66
1.83
1.8
2.2
—
—
—
0
0
11
47
2.44
1.82
1.4
1.2
—
—
—
0
0
8
29
2.84
1.81
1.1
1.7
—
—
—
0
0
60
450
1.52
1.77
6.3
3.1
—
—
—
0
0
142
1284
1.78
1.76
37.1
16.3
139.4
139.6
mmol/l
0.45
134
1254
5
13
3.93
1.72
1.0
1.2
—
—
—
0
0
142
1287
1.77
1.70
36.4
16.4
4.0
4.0
mmol/l
0.80
134
1253
14
69
2.12
1.70
6.3
7.4
24.6
24.8
mmol/l
0.11
14
63
56
417
1.52
1.69
7.2
2.3
49.1
57.4
u/l
1.63
48
383
128
1133
1.59
1.65
5.7
4.6
2.0
1.9
mu/l
0.18
109
1030
5
14
3.65
1.62
1.2
2.1
—
—
—
0
0
5
14
3.65
1.62
1.8
4.2
—
—
—
0
0
5
14
3.65
1.62
1.2
2.1
—
—
—
0
0
5
14
3.65
1.62
1.4
1.3
—
—
—
0
0
5
14
3.65
1.62
1.2
2.1
—
—
—
0
0
41
290
1.55
1.55
1.3
1.3
0.9
1.5
u/ml
—
8
82
7
28
2.56
1.47
20.4
1.1
1.1
0.8
nmol/l
—
7
23
47
349
1.48
1.42
4.7
2.9
0.2
0.4
e6/l
0.81
39
261
14
75
1.95
1.39
6.1
7.2
25.0
24.8
mmol/l
0.05
14
75
137
1252
1.57
1.32
31.7
14.3
27.4
23.2
mg/l
0.61
116
982
106
928
1.40
1.24
4.9
3.8
15.1
14.7
pmol/l
0.76
94
841
105
918
1.40
1.23
4.7
3.9
17.6
11.7
mm/h
2.60
94
845
13
71
1.90
1.23
1.5
1.4
—
—
—
0
0
36
261
1.48
1.21
2.7
1.9
1.3
1.3
mg/l
0.02
26
210
8
39
2.10
1.17
1.3
1.7
—
—
—
0
0
87
744
1.36
1.14
11.9
9.5
5.1
4.1
e9/l
0.94
78
655
8
40
2.05
1.13
1.1
1.7
—
—
—
0
0
5
21
2.42
1.10
1.8
1.8
—
99.3
—
0
6
5
21
2.42
1.10
1.2
1.9
—
—
—
0
0
27
189
1.51
1.08
3.7
2.9
3.4
2.2
e6/l
0.38
18
104
9
45
2.06
1.07
2.0
2.4
—
—
—
0
0
45
349
1.40
1.07
4.8
3.9
0.0
0.0
estimate
0.00
13
116
5
22
2.31
1.04
1.2
1.1
—
—
—
0
0
29
208
1.48
1.03
3.8
2.6
1.1
1.1
e6/l
0.02
20
122
37
280
1.41
1.00
4.1
2.3
—
—
—
0
0
47
373
1.36
0.97
3.6
3.3
2563.6
1331.8
ng/l
0.74
40
307
7
37
1.93
0.95
4.0
2.5
25.4
24.5
mmol/l
—
7
32
92
809
1.31
0.93
3.9
3.2
46.9
48.7
u/l
0.12
82
764
30
223
1.42
0.90
4.2
3.0
2.5
2.5
mmol/l
0.35
24
195
40
315
1.36
0.86
3.9
3.0
391.0
6155.9
umol/l
1.30
30
271
141
1327
1.44
0.85
15.8
10.2
27.9
25.9
u/l
0.63
134
1279
12
76
1.62
0.74
1.3
1.3
—
—
—
0
0
9
56
1.64
0.73
2.8
3.4
8.6
175.2
u/ml
—
9
48
5
27
1.88
0.69
1.4
1.7
—
—
—
0
0
5
28
1.81
0.66
1.2
1.8
—
—
—
0
0
126
1181
1.29
0.65
5.9
4.6
6.5
6.0
mmol/l
1.01
112
1083
10
152
0.64
0.65
2.8
2.2
—
—
—
0
0
16
219
0.70
0.63
2.8
2.8
1.1
0.7
ug/l
—
9
145
0
20
0.00
0.61
0.0
1.1
—
1.4
—
0
12
0
23
0.00
0.58
0.0
3.5
—
—
—
0
0
15
204
0.71
0.57
1.2
1.2
12.2
31.7
iu/ml
—
5
66
9
60
1.53
0.55
7.2
2.8
1.2
1.1
%
—
9
60
24
301
0.76
0.55
4.9
4.6
34.7
23.0
%
1.83
11
146
144
1391
1.28
0.43
43.4
21.1
130.2
135.4
g/l
3.62
139
1371
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
1.2
—
6.5
—
0
9
67
609
1.17
0.40
4.4
3.7
0.0
0.0
estimate
0.00
13
124
10
136
0.72
0.39
2.6
2.0
—
—
—
0
0
9
69
1.32
0.38
1.0
1.0
—
—
—
0
0
12
92
1.33
0.32
2.2
3.0
70.1
67.6
ml/min/173m2
—
7
36
67
619
1.14
0.31
4.4
3.7
0.0
0.0
estimate
0.00
13
113
119
1143
1.15
0.29
9.0
5.9
44.1
40.2
mmol/mol
2.06
104
1069
127
1227
1.15
0.28
5.6
4.9
2.6
2.7
mmol/l
0.34
108
1127
136
1321
1.17
0.27
33.4
16.6
87.9
78.4
umol/l
1.31
136
1321
66
614
1.12
0.27
5.5
5.0
0.0
0.0
estimate
0.00
13
120
15
180
0.82
0.26
1.7
1.4
—
—
—
0
0
120
1159
1.13
0.25
4.8
4.0
1.6
1.3
mmol/l
2.29
101
1058
37
336
1.13
0.22
1.7
1.7
1.6
1.3
mmol/l
0.62
30
283
5
42
1.20
0.21
5.0
2.4
—
—
—
0
0
74
779
0.91
0.21
3.3
3.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.8
—
977.6
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
452.7
—
0
7
0
13
0.00
0.21
0.0
1.1
—
41.0
—
0
7
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
24
214
1.14
0.18
1.6
1.5
—
—
—
0
0
60
573
1.07
0.13
4.8
4.2
—
—
—
0
0
114
1117
1.07
0.10
32.3
15.3
37.3
40.0
%
1.97
67
821
123
1208
1.07
0.10
5.3
4.4
4.5
4.6
mmol/l
0.36
105
1119
5
48
1.04
0.09
1.2
2.0
5.0
3.2
mg/l
—
5
33
122
1202
1.06
0.07
5.4
4.4
1.3
1.5
mmol/l
4.54
104
1103
117
1158
1.03
0.03
25.8
13.6
74.1
80.7
ml/min/173m2
1.70
91
942
40
401
1.00
0.00
4.2
4.8
2.0
2.2
ug/l
0.15
30
349
49
494
0.99
0.00
4.7
3.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
7.0
—
235.5
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
0.00
0.0
4.7
—
61.3
—
0
7
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
3.0
—
12.8
—
0
7
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_VISIMPBILATERAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_VISIMPBILATERAL | 2.117 [1.63, 2.75] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.088 |
During the follow-up period (1.1.1998 — 31.12.2019), 416 out of 1022 females with H7_VISIMPBILATERAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_VISIMPBILATERAL | 2.19 [1.67, 2.87] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 413 out of 986 males with H7_VISIMPBILATERAL died.
Mortality risk
Mortality risk for people of age
years, who have H7_VISIMPBILATERAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.167% | 0.477% |
| 5 | 0.988% | 2.345% |
| 10 | 2.677% | 6.198% |
| 15 | 5.119% | 11.656% |
| 20 | 9.06% | 20.056% |
Relationships between endpoints
↥Index endpoint: H7_VISIMPBILATERAL – Blindness or visual impairment, binocular
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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