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Perichondritis of external ear

DOID EFO Endpoint Browser PheWeb

H8_PERCHRONDR

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H61.0
  • Hospital discharge: ICD-9 — 3800
  • Hospital discharge: ICD-8 — 38798
  • Cause of death: ICD-10 — H61.0
  • Cause of death: ICD-9 — 3800
  • Cause of death: ICD-8 — 38798

2 out of 7 registries used, show all original rules.

626

4. Check minimum number of events

None

626

5. Include endpoints

None

626

6. Filter based on genotype QC (FinnGen only)

626

Control definitions (FinnGen only)

Control exclude
H8_EXTERNAL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H61
Name in latin
Perichondritis auris externae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4952 2479 2432
Only index persons 4192 2180 2012
Unadjusted period prevalence (%)
Whole population 0.07 0.07 0.07
Only index persons 0.08 0.08 0.08
Median age at first event (years)
Whole population 49.13 53.02 45.11
Only index persons 47.52 51.82 42.85

-FinnGen-

Key figures

All Female Male
Number of individuals 626 336 290
Unadjusted period prevalence (%) 0.12 0.11 0.13
Median age at first event (years) 48.05 50.20 45.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
548
Matched controls
5479
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H61.0
ICD-10 Finland
Perichondritis of external ear
+∞
323.0
286
*
38798
ICD-8 Finland
Other disease of ear and mastoid process, Alii definiti
+∞
257.1
226
*
3800A
ICD-9 Finland
Disorders of external ear, Perichondritis of pinna
+∞
43.3
41
*
DAB00
NOMESCO Finland
Excision of lesion of auricle
22.0
26.9
39
19
H61.8
ICD-10 Finland
Other specified disorders of external ear
98.2
17.7
19
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.4
16.8
88
293
J01DA01
ATC
[U] cefalexin; systemic
2.2
16.2
365
2627
H62.0*A46
ICD-10 Finland
Otitis externa in erysipelas
153.9
14.5
15
*
H60.9
ICD-10 Finland
Otitis externa, unspecified
5.2
14.4
45
93
TDA10
NOMESCO Finland
Needle biopsy of auricle or external auditory canal
143.3
13.5
14
*
D23.2
ICD-10 Finland
Benign neoplasm: Skin of ear and external auricular canal
14.5
12.8
21
15
H61.2
ICD-10 Finland
Impacted cerumen
4.1
10.8
42
109
4141
FHL
Myringoplasty (also for reasons other than inflammation)
22.0
10.7
15
7
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
2.2
10.5
118
604
H60.1
ICD-10 Finland
Cellulitis of external ear
12.4
10.4
18
15
L57.0
ICD-10 Finland
Actinic keratosis
2.6
10.2
79
335
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.6
9.4
69
285
SPAT1153
SPAT
Removal of sutures
1.8
9.0
186
1200
H29
ICPC
Ear symptom/complaint other
2.5
8.5
69
300
H66.0
ICD-10 Finland
Acute suppurative otitis media
3.5
8.2
37
111
H60.8
ICD-10 Finland
Other otitis externa
7.0
8.1
19
28
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
4.2
8.0
29
72
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
6.2
7.9
20
33
H71
ICD-10 Finland
Cholesteatoma of middle ear
11.0
7.8
14
13
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
5.7
7.7
21
38
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
15.3
7.7
12
8
UDC00
NOMESCO Finland
Ear microscopy
2.7
7.7
50
193
H60.3
ICD-10 Finland
Other infective otitis externa
12.1
7.6
13
11
M94.1
ICD-10 Finland
Relapsing polychondritis
81.1
7.4
8
*
J01DB01
ATC
cefalexin; oral
1.8
7.3
424
3622
A46
ICD-10 Finland
Erysipelas
2.1
7.2
90
479
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.1
7.1
83
428
SPAT1301
SPAT
No procedures
1.7
7.0
183
1251
E0000UV
ATC
NA
1.7
6.8
200
1414
H62.0
ICD-10 Finland
Otitis externa in bacterial diseases classified elsewhere
40.5
6.8
8
*
J01FF01
ATC
clindamycin; systemic
1.8
6.7
143
916
E000001
ATC
NA
1.9
6.7
112
667
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.5
6.6
49
204
SPAT1263
SPAT
Sampling
1.6
6.6
225
1649
H01
ICPC
Ear pain/earache
2.4
6.5
54
237
D07AB02
ATC
hydrocortisone butyrate; topical
1.7
6.5
144
937
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
6.5
123
761
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.1
6.4
74
381
SPAT1254
SPAT
Administration of medicine
1.9
6.2
88
494
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.9
6.2
86
479
J01MA02
ATC
ciprofloxacin; systemic
1.6
6.1
210
1535
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.2
6.1
59
281
S02CA02
ATC
flumetasone and antiinfectives; otic
2.6
6.1
41
164
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
3.8
6.1
24
66
H92.0
ICD-10 Finland
Otalgia
3.2
6.0
29
93

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
87
381
2.49
12.61
5.0
4.3
—
—
—
0
0
78
350
2.40
10.68
8.0
6.6
25.0
24.2
mmol/l
0.98
73
329
113
631
1.97
8.86
6.2
6.5
2.3
1.3
mmol/l
1.61
90
487
113
637
1.94
8.61
6.2
6.4
11.2
12.0
kpa
1.18
108
610
113
637
1.94
8.61
6.2
6.4
5.3
5.1
kpa
0.75
107
607
234
1668
1.64
7.87
7.2
5.5
—
—
—
0
0
267
1969
1.62
7.82
2.4
2.2
—
—
—
0
0
335
2619
1.60
7.63
7.8
6.4
1.2
1.2
mmol/l
1.45
294
2214
171
1138
1.69
7.43
5.1
4.5
1.0
1.0
kg/l
0.09
25
152
123
754
1.79
7.12
2.4
1.9
—
—
—
0
0
310
2407
1.57
7.08
6.5
5.5
1.2
1.2
mmol/l
2.57
286
2172
209
1493
1.60
6.76
5.0
4.2
—
—
—
0
0
102
606
1.82
6.53
2.3
1.7
—
—
—
0
0
221
1618
1.57
6.36
2.3
2.1
151.3
297.6
u/l
1.58
209
1522
432
3696
1.54
5.82
5.4
4.2
14.4
13.2
mm/h
0.88
402
3393
268
2083
1.50
5.70
2.8
2.7
152.1
141.2
ug/l
0.23
235
1906
287
2274
1.48
5.49
6.3
4.5
34.5
35.1
g/l
0.90
269
2115
100
623
1.72
5.41
1.4
1.3
430.0
469.4
titre
0.12
24
132
307
2490
1.46
5.08
6.9
5.5
0.0
0.0
e9/l
0.41
280
2153
274
2179
1.46
5.01
12.0
10.1
1.2
1.3
inr
0.27
53
615
361
3029
1.45
4.94
5.8
4.5
6.7
6.7
mmol/l
0.10
338
2834
314
2569
1.45
4.90
7.2
5.7
0.2
0.2
e9/l
0.64
287
2250
288
2320
1.45
4.88
7.5
5.6
2.8
2.8
%
0.08
274
2160
304
2478
1.44
4.81
6.8
5.5
0.6
0.6
e9/l
0.41
276
2138
289
2334
1.44
4.81
8.1
5.9
8.6
8.7
%
0.25
273
2185
181
1337
1.50
4.76
2.5
2.2
3.0
3.2
mg/l
0.48
154
1133
94
596
1.68
4.76
1.7
1.4
—
—
—
0
0
309
2532
1.44
4.72
7.2
5.5
2.1
1.9
e9/l
0.59
279
2223
329
2728
1.43
4.71
6.6
6.1
11.1
11.4
umol/l
0.16
312
2580
150
1069
1.53
4.67
2.0
1.8
1275.6
1179.6
nmol/l
0.61
119
801
302
2477
1.42
4.53
4.6
4.0
0.0
0.0
estimate
0.00
42
472
178
1323
1.48
4.51
3.3
2.7
9278.9
7426.6
umol/l
0.15
150
1128
51
273
1.95
4.51
8.1
8.6
—
—
—
0
0
344
2896
1.42
4.41
11.4
9.0
4.4
4.1
e9/l
1.14
312
2528
278
2257
1.42
4.36
7.5
5.6
0.7
0.7
%
0.56
264
2106
76
466
1.72
4.35
1.8
1.9
373.3
376.3
nmol/l
0.04
68
429
286
2339
1.41
4.28
7.9
5.5
57.8
57.9
%
0.08
269
2191
290
2378
1.41
4.27
8.1
5.8
27.7
27.0
%
0.42
275
2212
138
992
1.50
4.08
5.0
4.1
106.1
218.4
ng/l
1.22
116
816
104
703
1.57
4.07
1.3
1.2
—
—
—
0
0
268
2184
1.40
4.02
2.3
2.1
94.2
93.6
pmol/l
0.07
148
1137
214
1692
1.40
3.79
3.6
3.0
1359.7
1626.6
ng/l
0.48
186
1443
440
3918
1.41
3.78
9.2
7.5
80.5
79.0
u/l
0.25
415
3677
171
1300
1.43
3.77
1.7
1.6
20.8
20.7
nmol/l
0.02
156
1102
252
2049
1.38
3.77
4.9
3.9
44.5
56.8
ng/l
0.26
189
1507
300
2511
1.37
3.75
4.7
4.0
0.0
0.0
estimate
0.50
42
452
111
777
1.52
3.71
1.3
1.3
7.5
12.5
u/ml
0.55
32
284
203
1606
1.39
3.54
3.3
2.3
60.8
56.4
u/l
0.53
193
1486
114
819
1.48
3.35
3.1
1.8
29.5
29.7
s
0.14
109
790
15
54
2.82
3.27
1.8
1.5
—
—
—
0
0
15
54
2.82
3.27
1.8
1.5
—
—
—
0
0
15
54
2.82
3.27
1.8
1.5
—
—
—
0
0
15
54
2.82
3.27
1.8
1.5
—
—
—
0
0
113
818
1.47
3.20
1.3
1.3
38.7
39.6
iu/ml
0.02
39
260
38
209
1.87
3.16
5.9
3.9
1.2
1.4
mmol/l
0.56
38
204
292
2480
1.33
3.13
6.2
5.4
0.0
0.0
estimate
0.00
42
466
528
4918
1.47
3.08
22.7
15.4
26.5
24.7
mg/l
0.55
452
3965
200
1611
1.35
3.04
3.5
3.7
7.4
7.4
ph
0.46
24
296
144
1101
1.40
3.02
1.8
1.7
1.5
1.2
mg/l
0.33
117
854
72
482
1.56
2.95
2.8
2.5
4.2
6.4
ug/l
1.28
64
431
51
316
1.67
2.86
2.5
2.9
4.1
3.9
e9/l
0.19
37
236
38
220
1.77
2.71
1.3
1.2
—
—
—
0
0
54
346
1.61
2.67
2.5
2.2
13.0
13.3
nmol/l
0.10
45
306
396
3557
1.31
2.66
4.8
4.1
—
—
—
0
0
12
43
2.83
2.66
1.0
1.0
—
—
—
0
0
66
445
1.54
2.63
3.4
3.7
—
—
—
0
0
43
261
1.70
2.62
3.2
2.8
4.3
4.5
pmol/l
0.71
38
221
60
398
1.56
2.58
4.2
2.3
—
—
—
0
0
388
3484
1.30
2.57
5.9
4.5
—
—
—
0
0
204
1686
1.31
2.53
3.8
3.3
—
—
—
0
0
158
1260
1.34
2.52
7.1
6.8
—
—
—
0
0
63
425
1.54
2.52
4.4
4.1
1.0
0.9
%
0.07
26
143
108
811
1.40
2.50
2.9
3.2
0.8
0.8
mmol/l
0.06
103
752
15
64
2.38
2.40
2.3
4.0
—
—
—
0
0
541
5116
1.42
2.39
24.9
18.0
139.6
139.6
mmol/l
0.09
534
4989
542
5129
1.42
2.36
24.8
18.1
4.0
4.0
mmol/l
0.01
535
4996
214
1797
1.29
2.33
3.6
3.4
2.3
2.3
mmol/l
1.24
195
1545
57
383
1.54
2.33
4.1
4.0
0.7
0.4
%
0.43
22
103
45
287
1.61
2.29
2.6
2.4
—
—
—
0
0
270
2339
1.27
2.28
4.8
4.0
—
—
—
0
0
8
23
3.51
2.27
2.0
3.5
1113.6
916.0
u/ml
—
8
23
24
128
1.91
2.24
7.4
3.5
—
—
—
0
0
146
1171
1.32
2.22
4.5
4.0
—
—
—
0
0
71
505
1.46
2.22
5.8
4.2
—
—
—
0
0
408
3724
1.27
2.19
4.9
3.9
15.1
14.9
pmol/l
0.47
369
3353
44
287
1.57
2.07
1.1
1.2
205.6
132.7
iu/ml
0.47
20
106
535
5079
1.37
2.04
22.3
14.6
—
—
—
0
0
93
708
1.37
2.00
38.9
26.1
1.8
1.3
inr
—
9
82
22
120
1.86
1.95
2.8
1.5
—
—
—
0
0
77
571
1.40
1.94
2.8
2.4
11.2
8.5
umol/l
0.45
67
497
7
22
3.21
1.88
1.4
1.5
—
—
—
0
0
29
175
1.69
1.86
1.3
2.4
37.6
36.9
g/l
0.24
23
149
19
101
1.91
1.82
1.6
1.3
—
—
—
0
0
35
224
1.60
1.80
7.3
4.3
—
—
—
0
0
478
4499
1.26
1.72
5.9
4.7
2.0
1.9
mu/l
0.41
439
4072
21
118
1.81
1.72
1.5
1.7
43.7
42.2
nmol/l
0.07
21
113
137
1131
1.27
1.66
2.0
1.8
397.1
12567569.1
pmol/l
0.80
110
931
69
517
1.38
1.65
3.9
3.5
—
—
—
0
0
5
14
3.59
1.62
1.0
1.2
—
—
—
0
0
5
14
3.59
1.62
1.0
1.2
—
—
—
0
0
5
14
3.59
1.62
1.0
1.2
—
—
—
0
0
10
43
2.35
1.61
1.3
1.2
—
—
—
0
0
163
1381
1.24
1.58
5.5
4.3
0.0
0.0
estimate
0.69
39
449
82
642
1.32
1.49
2.4
2.5
1.8
1.8
%
0.02
71
574
49
353
1.42
1.49
1.2
1.2
—
—
—
0
0
28
179
1.59
1.48
6.6
3.3
45.5
97.4
mg/l
0.78
23
142
6
22
2.74
1.43
11.2
16.4
1217.3
1644.8
nmol/l
—
6
22
177
1528
1.22
1.43
3.8
3.2
2355.2
270.4
mg/l
1.76
119
972
9
39
2.33
1.43
1.3
1.6
—
—
—
0
0
62
470
1.35
1.41
2.6
2.8
68.3
69.6
e9/l
0.10
52
376
51
375
1.39
1.39
1.5
1.4
—
—
—
0
0
54
402
1.38
1.37
4.5
4.2
0.1
0.1
%
0.03
22
131
9
42
2.16
1.34
1.1
1.2
—
—
—
0
0
9
42
2.16
1.34
1.7
1.3
—
—
—
0
0
38
267
1.45
1.33
4.8
3.2
25.3
25.0
mmol/l
0.26
38
262
11
54
2.06
1.33
1.2
1.3
—
—
—
0
0
51
380
1.37
1.30
4.8
4.2
0.0
0.9
%
0.53
21
112
8
34
2.37
1.29
3.0
1.4
—
—
—
0
0
37
262
1.44
1.26
1.6
1.9
1.6
1.6
g/l
0.08
32
233
27
179
1.53
1.25
6.8
3.3
41.0
28.7
mg/l
0.89
22
144
23
147
1.59
1.24
1.2
1.4
283.6
281.7
ug/g
0.02
14
87
557
5394
1.30
1.24
32.7
22.7
249.4
246.5
e9/l
0.44
550
5259
557
5396
1.29
1.22
32.5
22.7
7.2
6.8
e9/l
1.82
545
5243
557
5396
1.29
1.22
32.6
22.7
4.4
4.4
e12/l
3.07
546
5244
64
500
1.31
1.21
4.0
3.4
2.8
1.9
mmol/l
1.04
52
396
540
5214
1.26
1.20
13.8
10.7
25.1
25.7
u/l
0.37
523
5024
557
5398
1.29
1.20
32.7
22.8
131.9
134.0
g/l
2.66
552
5312
12
64
1.89
1.18
1.2
1.3
0.5
0.6
nmol/l
0.21
12
59
30
207
1.47
1.17
2.0
1.9
—
—
—
0
0
17
102
1.69
1.17
2.9
1.4
0.7
0.9
nmol/l
0.39
11
86
7
30
2.35
1.12
1.4
1.4
0.9
1.0
g/l
—
7
30
7
30
2.35
1.12
1.6
2.0
0.3
0.2
e9/l
—
7
25
15
88
1.72
1.12
2.4
2.9
3.5
4.6
e9/l
0.92
15
88
64
507
1.29
1.11
4.0
3.4
5.9
5.8
kpa
0.16
64
492
92
765
1.24
1.07
2.6
2.4
2.5
2.3
g/l
2.61
86
708
100
840
1.23
1.06
2.6
2.4
11.5
12.6
umol/l
0.90
92
770
107
906
1.22
1.05
1.8
1.5
2.3
2.5
g/l
0.40
60
544
9
46
1.97
1.04
1.7
1.5
—
—
—
0
0
11
60
1.85
1.03
1.2
1.3
—
—
—
0
0
118
1014
1.20
1.00
1.3
1.2
0.8
1.5
u/ml
1.30
28
269
14
85
1.66
0.95
1.4
1.3
—
—
—
0
0
15
93
1.63
0.94
2.5
3.3
55.4
59.4
%
0.48
15
93
173
1546
1.16
0.94
4.7
4.0
—
—
—
0
0
23
160
1.45
0.90
1.6
1.6
—
—
—
0
0
36
272
1.34
0.89
1.3
1.2
324.8
262.7
u/ml
0.12
31
248
86
726
1.21
0.89
2.7
2.4
20.0
22.1
%
0.66
59
613
177
1591
1.16
0.89
3.4
3.1
7.3
7.2
mmol/l
0.04
161
1329
54
436
1.26
0.84
3.7
2.7
4.1
4.4
kpa
0.68
54
418
151
1348
1.16
0.83
4.5
3.6
—
—
—
0
0
11
65
1.70
0.82
1.7
2.6
—
—
—
0
0
13
81
1.62
0.81
3.7
2.8
—
—
—
0
0
10
58
1.74
0.80
1.2
1.3
—
—
nmol/l
—
0
0
43
340
1.28
0.80
4.5
3.2
—
—
—
0
0
35
269
1.32
0.79
2.9
2.3
0.7
0.7
%
0.35
35
260
141
1570
0.87
0.76
3.1
3.0
—
—
—
0
0
14
92
1.53
0.73
2.0
1.6
—
—
—
0
0
9
56
1.62
0.72
1.2
1.3
—
—
—
0
0
10
60
1.68
0.72
1.4
1.4
—
—
—
0
0
7
40
1.76
0.71
1.1
1.2
350.0
369.4
nmol/l
—
7
35
5
26
1.93
0.70
1.4
1.3
149.4
134.4
nmol/l
—
5
26
11
69
1.60
0.68
1.3
1.7
—
—
—
0
0
16
111
1.45
0.66
4.5
4.6
3.2
3.0
mmol/l
—
9
79
24
180
1.35
0.66
1.1
1.1
—
—
—
0
0
175
1604
1.13
0.66
2.8
2.4
—
—
—
0
0
74
638
1.18
0.64
1.4
1.3
—
—
—
0
0
65
555
1.19
0.63
2.4
2.2
110.3
140.2
ug/g
0.70
47
437
19
138
1.39
0.63
2.0
2.4
13.4
69.7
ug/min
—
10
78
474
4598
1.13
0.62
7.2
6.1
40.7
40.3
mmol/mol
0.38
448
4248
12
175
0.68
0.61
1.3
1.7
—
—
—
0
0
176
1621
1.12
0.61
4.3
4.0
4.7
8.5
mg/mmol
1.69
119
1034
0
22
0.00
0.59
0.0
2.4
—
—
—
0
0
10
64
1.57
0.59
1.1
1.2
—
—
—
0
0
8
53
1.52
0.58
1.4
1.2
—
—
—
0
0
113
1249
0.88
0.56
1.3
1.3
—
—
—
0
0
72
629
1.16
0.55
1.9
1.7
—
—
—
0
0
33
267
1.25
0.55
4.1
4.0
—
—
—
0
0
52
442
1.19
0.55
1.4
1.5
—
—
—
0
0
64
555
1.17
0.54
1.5
1.3
—
—
—
0
0
6
39
1.54
0.53
1.3
1.2
—
—
—
0
0
118
1071
1.13
0.53
5.5
4.7
—
—
—
0
0
6
100
0.60
0.52
2.2
1.7
—
—
—
0
0
41
487
0.83
0.51
1.5
1.6
—
—
—
0
0
11
75
1.48
0.51
1.5
1.5
—
—
—
0
0
6
41
1.47
0.50
1.0
1.2
—
—
—
0
0
51
439
1.18
0.48
5.8
7.1
—
—
—
0
0
492
4808
1.11
0.47
5.3
4.8
6.0
6.0
mmol/l
0.28
457
4346
14
102
1.38
0.47
1.4
1.3
2.1
13.0
e6/l
—
9
76
15
111
1.36
0.47
2.3
1.5
7.7
6.3
iu/l
—
6
31
13
94
1.39
0.46
1.7
2.6
—
—
—
0
0
7
51
1.38
0.44
5.9
2.3
—
—
—
0
0
7
51
1.38
0.44
3.1
2.7
—
—
—
0
0
52
453
1.16
0.43
1.7
1.5
—
—
—
0
0
15
113
1.34
0.43
2.1
2.2
—
—
—
0
0
17
131
1.31
0.42
1.2
1.2
—
—
—
0
0
29
348
0.83
0.42
1.4
1.4
—
—
—
0
0
5
32
1.57
0.42
3.0
2.1
3.0
2.5
ug/l
—
5
27
35
296
1.19
0.41
1.3
1.4
—
—
—
0
0
5
33
1.52
0.41
2.6
2.0
6.8
4.1
ug/l
—
5
28
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
0.7
—
0
7
0
16
0.00
0.41
0.0
2.2
—
—
—
0
0
20
159
1.27
0.40
28.9
10.9
—
—
—
0
0
114
1051
1.10
0.40
3.6
3.2
2.5
2.5
mmol/l
0.07
99
917
5
35
1.43
0.39
1.6
1.2
—
—
—
0
0
59
524
1.14
0.39
1.7
1.5
—
—
—
0
0
33
280
1.19
0.38
1.3
1.2
—
—
—
0
0
13
98
1.33
0.37
1.2
1.1
—
—
—
0
0
31
263
1.19
0.36
1.3
1.3
—
—
—
0
0
139
1308
1.08
0.32
1.8
1.7
1.4
1.4
mmol/l
0.15
119
1086
10
74
1.36
0.32
1.5
1.4
—
—
—
0
0
10
132
0.75
0.32
1.2
1.3
—
—
—
0
0
7
52
1.35
0.31
1.0
1.1
1.5
1.5
g/l
—
7
47
29
249
1.17
0.31
4.9
3.6
—
—
—
0
0
7
97
0.72
0.31
1.3
2.0
61.5
57.8
%
—
7
97
7
54
1.30
0.30
1.1
1.5
275.9
274.8
mosm/kgh2o
—
7
40
7
54
1.30
0.30
4.3
3.4
—
—
—
0
0
153
1612
0.93
0.30
3.7
3.3
36.5
116.3
e6/l
1.14
124
1243
38
428
0.88
0.28
5.5
3.8
—
—
—
0
0
22
186
1.19
0.28
3.0
3.3
0.2
0.2
g/l
—
7
70
128
1211
1.07
0.27
2.5
2.3
—
—
—
0
0
14
171
0.81
0.26
1.0
1.2
—
—
—
0
0
5
72
0.69
0.26
1.2
2.1
32.4
32.7
pg
—
5
72
489
4819
1.07
0.26
5.1
4.5
4.5
4.6
mmol/l
1.27
457
4426
46
418
1.11
0.24
3.8
3.7
98.6
85.9
ng/l
0.39
39
369
13
106
1.23
0.23
4.4
3.7
—
—
—
0
0
500
4937
1.06
0.23
5.7
5.1
2.6
2.7
mmol/l
1.82
468
4501
177
1702
1.06
0.23
5.2
5.1
3.1
2.7
ug/l
0.33
156
1520
5
41
1.22
0.22
1.2
1.1
—
2.7
—
0
8
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
2.4
—
0
14
110
1048
1.06
0.20
3.3
2.9
570.5
555.0
mosm/kgh2o
0.31
93
895
13
109
1.20
0.18
1.4
1.5
—
—
—
0
0
7
58
1.21
0.18
1.6
2.5
—
—
—
0
0
468
4625
1.05
0.18
4.4
4.0
1.4
1.3
mmol/l
2.03
433
4195
17
148
1.15
0.17
3.5
3.3
—
—
—
0
0
8
69
1.16
0.16
1.0
1.0
—
—
—
0
0
484
4791
1.05
0.16
4.8
4.5
1.4
1.5
mmol/l
0.72
450
4373
10
83
1.21
0.15
1.2
1.3
—
—
—
0
0
41
440
0.93
0.15
3.8
3.4
1.2
1.2
mmol/l
0.37
33
382
17
151
1.13
0.13
5.6
5.1
—
—
—
0
0
61
580
1.06
0.13
3.7
4.1
12.4
32.5
ug/l
0.69
51
495
13
148
0.88
0.12
1.5
1.1
—
—
—
0
0
10
85
1.18
0.12
1.8
1.6
—
—
—
0
0
439
4351
1.03
0.11
23.6
16.7
39.1
39.4
%
0.32
275
2951
13
115
1.13
0.10
1.4
1.5
—
—
—
0
0
29
271
1.07
0.10
1.7
1.5
—
—
—
0
0
30
320
0.93
0.10
1.4
1.4
—
—
—
0
0
13
116
1.12
0.09
1.4
1.5
—
—
—
0
0
13
116
1.12
0.09
1.4
1.5
—
—
—
0
0
97
997
0.97
0.08
3.3
3.0
0.7
0.8
ug/l
0.64
68
666
12
107
1.12
0.08
2.7
2.8
27.3
32.8
umol/l
—
7
83
19
175
1.09
0.08
1.2
1.3
1.3
1.2
g/l
0.99
19
167
46
440
1.05
0.08
1.4
1.4
—
—
—
0
0
21
226
0.93
0.08
1.8
1.4
—
—
—
0
0
13
117
1.11
0.08
1.4
1.5
—
—
—
0
0
7
64
1.09
0.08
1.1
1.2
—
—
—
0
0
20
215
0.93
0.07
2.8
2.8
—
—
—
0
0
8
75
1.07
0.07
1.0
1.0
—
—
—
0
0
13
118
1.10
0.07
1.7
2.5
7.4
7.8
kpa
0.76
13
105
9
86
1.05
0.07
1.3
1.2
—
—
—
0
0
11
122
0.90
0.07
1.1
1.1
—
—
—
0
0
8
91
0.88
0.07
4.8
2.3
—
—
—
0
0
13
119
1.09
0.06
1.2
1.2
—
—
—
0
0
139
1412
0.98
0.06
3.4
3.1
—
—
—
0
0
11
120
0.92
0.05
1.9
2.5
—
—
—
0
0
10
91
1.10
0.04
1.4
1.5
—
—
—
0
0
113
1114
1.02
0.04
2.9
2.6
6.1
5.6
e6/l
0.11
96
971
220
2192
1.01
0.01
10.8
9.4
0.0
0.0
e9/l
0.51
191
1787
17
168
1.01
0.00
1.2
1.3
0.3
0.2
g/l
1.37
17
160
185
1855
1.00
0.00
4.0
3.8
83.3
163.7
e6/l
0.83
141
1323
147
1467
1.00
0.00
3.4
3.2
0.8
0.5
e6/l
0.40
117
1096
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
18.3
—
0
9
0
9
0.00
0.00
0.0
1.3
—
59.4
—
0
9
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
17.2
—
0
8
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
7
69
1.01
0.00
2.1
1.1
—
—
—
0
0
8
86
0.93
0.00
2.1
2.9
—
—
—
0
0
7
73
0.96
0.00
1.1
2.1
—
—
—
0
0
0
6
0.00
0.00
0.0
3.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
5
58
0.86
0.00
1.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
1.8
—
0
8
5
59
0.85
0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
5
58
0.86
0.00
1.2
1.1
—
—
—
0
0
6
59
1.02
0.00
1.0
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H8_PERCHRONDR and mortality.

Females

Parameter HR [95% CI] p-value
H8_PERCHRONDR 1.613 [1.35, 1.93] < 0.001
Birth year 0.994 [0.99, 1.0] 0.2

During the follow-up period (1.1.1998 — 31.12.2019), 337 out of 1198 females with H8_PERCHRONDR died.

Males

Parameter HR [95% CI] p-value
H8_PERCHRONDR 1.223 [1.0, 1.49] 0.046
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 259 out of 924 males with H8_PERCHRONDR died.

Mortality risk

Mortality risk for people of age

years, who have H8_PERCHRONDR.

N-year risk Females Males
1 0.155% 0.181%
5 1.027% 1.238%
10 2.192% 3.306%
15 4.13% 6.583%
20 7.925% 10.866%

Relationships between endpoints

↥

Index endpoint: H8_PERCHRONDR – Perichondritis of external ear

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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