No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
654 |
4. Check minimum number of eventsNone |
654 |
5. Include endpointsNone |
654 |
6. Filter based on genotype QC (FinnGen only) |
636 |
Control definitions (FinnGen only)
- Control exclude
- H8_EXTERNAL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H61
- Name in latin
- Perichondritis auris externae
Similar endpoints
↥List of similar endpoints to
Perichondritis of external ear
based on the number of shared cases.
Similar with more cases:
- Diseases of external ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4952 | 2479 | 2432 |
| Only index persons | 4192 | 2180 | 2012 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.07 | 0.07 |
| Only index persons | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 49.13 | 53.02 | 45.11 |
| Only index persons | 47.52 | 51.82 | 42.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 636 | 341 | 295 |
| Unadjusted period prevalence (%) | 0.13 | 0.12 | 0.14 |
| Median age at first event (years) | 48.93 | 50.72 | 46.87 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 654
- Matched controls
- 6540
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H61.0
ICD-10 Finland
Perichondritis of external ear
7350.4
307.7
368
*
38798
ICD-8 Finland
Other disease of ear and mastoid process, Alii definiti
+∞
277.5
246
*
DAB00
NOMESCO Finland
Excision of lesion of auricle
18.6
61.5
50
29
3800A
ICD-9 Finland
Disorders of external ear, Perichondritis of pinna
+∞
50.7
48
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.6
29.8
114
366
H60.9
ICD-10 Finland
Otitis externa, unspecified
4.8
27.7
66
149
H61.2
ICD-10 Finland
Impacted cerumen
3.7
17.1
57
165
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.8
17.0
95
376
J01DA01
ATC
[U] cefalexin
2.0
16.2
433
3202
L57.0
ICD-10 Finland
Actinic keratosis
2.5
14.8
107
479
H61.8
ICD-10 Finland
Other specified disorders of external ear
21.6
14.7
21
10
H60.1
ICD-10 Finland
Cellulitis of external ear
12.9
14.5
25
20
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
4.5
14.2
35
81
H60.8
ICD-10 Finland
Other otitis externa
6.0
14.1
25
43
UDC00
NOMESCO Finland
Ear microscopy
2.9
13.8
67
245
H29
ICPC
Ear symptom/complaint other
2.5
13.7
93
404
4141
FHL
Myringoplasty (also for reasons other than inflammation)
26.4
13.4
18
7
D23.2
ICD-10 Finland
Benign neoplasm: Skin of ear and external auricular canal
11.8
13.4
24
21
H62.0*A46
ICD-10 Finland
Otitis externa in erysipelas
29.0
13.0
17
6
TDA10
NOMESCO Finland
Needle biopsy of auricle or external auditory canal
19.5
13.0
19
10
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
5.5
12.9
25
47
M94.1
ICD-10 Finland
Relapsing polychondritis
+∞
12.5
12
*
XQ848
NOMESCO Finland
Dermatological photography
4.0
11.5
33
86
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
11.4
159
919
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
4.1
11.1
31
79
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
5.0
10.8
23
47
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.9
10.3
143
823
H01
ICPC
Ear pain/earache
2.4
10.3
73
323
SPAT1254
SPAT
Administration of medicine
2.1
10.3
116
621
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.1
10.0
105
546
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.9
10.0
135
770
S02CA02
ATC
flumetasone and antiinfectives; otic
2.8
10.0
50
186
A46
ICD-10 Finland
Erysipelas
2.0
9.8
115
624
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
15.3
9.5
15
10
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.7
9.1
204
1354
SPAT1301
SPAT
No procedures
1.7
9.1
217
1466
SPAT1153
SPAT
Removal of sutures
1.7
8.9
221
1509
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
3.4
8.9
31
93
J01FF01
ATC
clindamycin; systemic
1.8
8.8
182
1180
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.5
8.8
58
248
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
8.7
223
1533
D07AB02
ATC
hydrocortisone butyrate; topical
1.7
8.6
192
1270
E0000UV, ,
ATC
1.6
8.5
264
1907
J01MA02
ATC
ciprofloxacin; systemic
1.6
8.3
257
1849
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.9
8.1
112
641
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
8.1
201
1367
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.0
8.0
90
480
H60.3
ICD-10 Finland
Other infective otitis externa
6.2
7.9
20
33
H62.0
ICD-10 Finland
Otitis externa in bacterial diseases classified elsewhere
45.5
7.7
9
*
E000001, ,
ATC
1.8
7.7
127
767
J01DB01
ATC
cefalexin; oral
1.7
7.7
517
4471
C44.22
ICD-10 Finland
Spinocellular carcinoma of the skin of the outer ear and the outer ear canal
18.6
7.6
11
6
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
7.6
89
481
S18
ICPC
Laceration/cut
1.6
7.5
303
2311
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.0
7.5
85
454
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.0
7.4
89
485
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.7
7.3
139
877
H92.0
ICD-10 Finland
Otalgia
2.7
7.2
39
151
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
7.2
188
1287
SPAT1263
SPAT
Sampling
1.6
7.1
269
2012
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.2
7.1
59
279
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
7.1
303
2331
C07AB07
ATC
bisoprolol; oral
1.6
7.1
338
2666
K59.09
ICD-10 Finland
Constipation, unspecified
2.3
7.1
52
234
H66.0
ICD-10 Finland
Acute suppurative otitis media
2.5
7.0
42
172
A28
ICPC
Limited function/disability NOS
1.7
7.0
133
838
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
3.5
6.9
23
67
A06AD11
ATC
lactulose; oral
1.8
6.8
114
691
ZXC50
NOMESCO Finland
Cryotherapy
3.0
6.8
29
99
H60.0
ICD-10 Finland
Abscess of external ear
40.5
6.8
8
*
D07AC01
ATC
betamethasone; topical
1.6
6.7
224
1623
J01CA04
ATC
amoxicillin; systemic
1.6
6.7
495
4284
H60
ICD-10 Finland
Otitis externa
2.8
6.7
32
116
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.0
6.7
73
384
J02AC01
ATC
fluconazole; systemic
1.6
6.6
220
1595
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
2.6
6.6
36
141
R06.0
ICD-10 Finland
Dyspnoea
1.6
6.5
183
1272
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
3.5
6.5
22
65
N05CD07
ATC
temazepam; oral
1.8
6.4
94
546
H61.1
ICD-10 Finland
Noninfective disorders of pinna
70.5
6.4
7
*
N06AA09
ATC
amitriptyline; systemic
2.0
6.4
67
347
SPAT1310
SPAT
Counselling related to known health issue
1.6
6.4
201
1435
H70
ICPC
Otitis externa
5.3
6.4
18
35
H66.9
ICD-10 Finland
Otitis media, unspecified
2.7
6.3
34
132
38199
ICD-8 Finland
Otitis media without mention of mastoiditis, Unspecified
26.9
6.2
8
*
A02BC03
ATC
lansoprazole; oral
1.6
6.2
193
1372
N05AX12
ATC
aripiprazole; systemic
3.3
6.2
23
72
H71
ICD-10 Finland
Cholesteatoma of middle ear
6.4
6.2
15
24
R50.9
ICD-10 Finland
Fever, unspecified
1.8
6.2
97
576
S97
ICPC
Chronic ulcer skin
2.2
6.1
51
242
A07AA02
ATC
nystatin; oral
2.3
6.1
47
216
L89
ICD-10 Finland
Decubitus ulcer and pressure area
3.7
6.1
19
53
WX704
NOMESCO Finland
Intubation
2.2
6.0
51
244
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
120
660
2.00
9.84
6.2
6.9
2.03
1.29
mmol/l
0.95
99
518
120
666
1.98
9.57
6.2
6.8
5.21
5.08
kpa
0.49
114
636
119
666
1.96
9.25
6.2
6.8
11.68
11.99
kpa
0.25
114
639
151
929
1.81
8.72
2.1
1.8
—
—
—
0
0
353
2745
1.62
8.36
7.9
6.6
1.21
1.21
mmol/l
1.37
311
2339
237
1678
1.65
8.16
2.3
2.1
150.96
292.58
u/l
1.59
224
1575
178
1181
1.70
7.80
5.0
4.5
1.02
1.02
kg/l
0.00
26
160
324
2520
1.57
7.29
6.6
5.6
1.20
1.21
mmol/l
2.51
302
2288
286
2183
1.55
6.87
2.9
2.7
147.36
141.22
ug/l
0.13
252
1996
27
90
3.09
6.57
2.8
6.0
2484.80
151.46
iu/ml
—
5
13
108
660
1.76
6.25
2.1
1.8
—
—
—
0
0
329
2628
1.51
6.18
23.0
16.4
1.33
1.29
inr
0.25
71
746
383
3169
1.50
5.99
6.0
4.6
6.69
6.75
mmol/l
0.20
359
2973
302
2389
1.49
5.84
6.4
4.5
34.52
35.12
g/l
0.97
284
2226
195
1411
1.54
5.75
2.5
2.1
3.04
3.19
mg/l
0.43
168
1190
349
2852
1.48
5.68
6.9
6.1
11.05
11.37
umol/l
0.20
333
2702
450
3879
1.51
5.56
5.5
4.2
14.31
13.15
mm/h
0.87
419
3558
104
657
1.69
5.32
2.1
1.7
—
—
—
0
0
273
2148
1.47
5.27
2.4
2.3
76.47
78.33
nmol/l
0.47
242
1910
304
2456
1.44
5.04
8.0
5.6
57.85
57.89
%
0.01
287
2309
364
3042
1.44
5.01
11.7
9.1
4.41
4.13
e9/l
1.24
330
2663
308
2498
1.44
4.98
8.2
5.8
27.67
27.01
%
0.38
293
2345
317
2586
1.44
4.96
4.7
4.0
0.00
0.00
estimate
0.50
51
530
69
397
1.83
4.88
1.7
1.6
—
—
—
0
0
80
484
1.74
4.78
1.8
1.9
381.18
377.22
nmol/l
0.06
72
444
156
1120
1.52
4.65
2.0
1.7
1262.62
1186.62
nmol/l
0.47
125
837
146
1038
1.52
4.55
5.2
4.1
99.07
295.69
ng/l
1.36
125
856
229
1781
1.44
4.54
3.5
3.0
1360.28
1632.58
ng/l
0.53
201
1520
44
223
2.04
4.52
2.7
2.4
—
—
—
0
0
24
93
2.64
4.52
1.4
1.5
—
—
—
0
0
182
1360
1.47
4.44
1.7
1.6
20.39
20.76
nmol/l
0.11
166
1147
282
2285
1.41
4.42
2.3
2.1
94.90
93.69
pmol/l
0.15
158
1193
212
1633
1.44
4.40
3.9
3.2
36.51
32.92
u/l
0.30
198
1560
316
2615
1.40
4.37
4.7
4.0
0.00
0.01
estimate
0.50
47
473
216
1672
1.44
4.36
3.4
2.3
60.63
61.85
u/l
0.09
204
1552
22
83
2.71
4.36
1.4
1.4
—
—
—
0
0
185
1397
1.45
4.25
3.3
2.7
8716.19
7032.07
umol/l
0.14
160
1202
123
856
1.54
4.21
3.1
1.9
29.69
29.73
s
0.03
118
824
463
4108
1.44
4.20
9.5
7.5
80.04
79.01
u/l
0.18
439
3855
266
2150
1.40
4.17
4.9
3.9
42.98
55.18
ng/l
0.27
201
1594
19
69
2.81
4.05
1.4
2.8
—
854.50
u/ml
—
0
6
20
75
2.72
4.02
1.3
1.5
—
—
—
0
0
97
655
1.56
3.79
4.6
4.0
252.27
260.13
u/l
0.19
90
617
307
2583
1.36
3.60
6.3
5.3
0.00
0.00
estimate
-0.00
47
489
41
221
1.91
3.58
5.9
3.9
1.21
1.41
mmol/l
0.86
41
216
115
818
1.49
3.54
1.3
1.3
7.49
12.05
u/ml
0.50
32
296
27
125
2.21
3.52
2.1
1.6
—
—
—
0
0
555
5154
1.51
3.49
23.0
15.4
26.06
24.63
mg/l
0.42
479
4159
16
58
2.80
3.44
1.8
1.5
—
—
—
0
0
16
58
2.80
3.44
1.7
1.5
—
—
—
0
0
77
504
1.60
3.44
2.8
2.5
4.60
6.35
ug/l
0.89
69
450
118
859
1.46
3.22
1.3
1.3
36.73
40.93
iu/ml
0.14
42
274
36
195
1.90
3.13
1.9
2.7
0.78
1.10
g/l
0.33
30
168
290
2460
1.32
3.07
3.0
2.5
—
—
—
0
0
244
2021
1.33
3.04
5.2
4.2
—
—
—
0
0
151
1166
1.38
2.96
1.7
1.7
1.43
1.24
mg/l
0.29
123
905
9
22
4.13
2.89
2.0
3.5
1129.11
925.45
u/ml
—
9
22
569
5363
1.47
2.79
25.2
18.1
139.59
139.64
mmol/l
0.19
562
5228
570
5376
1.47
2.77
25.1
18.2
3.99
3.99
mmol/l
0.10
563
5235
20
91
2.24
2.76
2.3
1.6
—
—
—
0
0
20
91
2.24
2.76
2.3
1.6
—
—
—
0
0
17
72
2.40
2.74
1.2
1.5
—
—
—
0
0
26
132
2.01
2.74
2.0
1.6
—
—
—
0
0
48
297
1.66
2.71
1.1
1.2
205.63
139.56
iu/ml
0.41
20
110
33
184
1.84
2.66
6.0
3.5
43.74
96.36
mg/l
0.83
27
146
11
35
3.18
2.65
5.2
1.7
—
—
—
0
0
55
358
1.59
2.55
2.6
2.1
13.10
13.15
nmol/l
0.01
46
317
45
279
1.66
2.53
3.2
2.7
4.24
4.49
pmol/l
0.77
40
238
430
3914
1.29
2.43
4.9
3.9
15.09
14.95
pmol/l
0.60
389
3518
32
184
1.78
2.36
6.2
3.5
39.13
36.63
mg/l
0.09
26
148
81
584
1.44
2.34
3.4
2.4
10.85
8.45
umol/l
0.40
71
509
8
23
3.51
2.27
1.4
1.4
1.39
1.53
g/l
—
8
23
93
694
1.40
2.23
10.7
8.1
—
—
—
0
0
364
3268
1.26
2.20
4.0
3.0
55.81
50.25
u/l
0.54
342
3034
36
220
1.67
2.17
2.1
1.9
—
—
—
0
0
72
516
1.44
2.16
1.4
1.6
1.51
1.50
%
0.03
59
433
147
1187
1.31
2.11
2.0
1.8
402.45
12049868.53
pmol/l
0.80
120
971
33
199
1.69
2.09
1.8
1.7
—
—
—
0
0
14
62
2.29
2.09
1.8
1.2
—
—
—
0
0
9
31
2.93
2.08
1.2
1.3
—
—
—
0
0
8
26
3.10
2.02
1.9
2.2
—
—
—
0
0
42
273
1.58
2.00
4.8
3.5
46.21
49.10
%
0.31
42
268
191
1606
1.27
1.99
3.8
3.3
2157.97
293.51
mg/l
1.69
130
1028
22
120
1.86
1.95
1.7
1.6
43.73
42.41
nmol/l
0.07
22
115
15
71
2.14
1.93
1.3
1.5
—
—
—
0
0
42
277
1.55
1.89
4.5
3.2
25.37
25.03
mmol/l
0.32
42
272
15
72
2.11
1.87
1.3
1.4
—
—
—
0
0
15
72
2.11
1.87
1.3
1.5
—
—
—
0
0
15
72
2.11
1.87
1.3
1.4
—
—
—
0
0
171
1433
1.26
1.82
5.4
4.3
0.00
0.01
estimate
0.69
44
470
504
4745
1.27
1.82
5.9
4.7
2.04
1.95
mu/l
0.38
464
4291
219
1890
1.24
1.80
3.6
3.5
2.33
2.35
mmol/l
1.25
201
1638
6
18
3.35
1.75
1.2
2.0
57.35
64.62
ug/l
—
6
18
7
24
2.94
1.72
10.7
17.8
1103.29
1680.21
nmol/l
—
7
24
8
31
2.60
1.66
1.3
1.3
—
—
—
0
0
8
32
2.52
1.60
1.4
1.4
0.89
0.97
g/l
—
8
32
70
532
1.35
1.54
3.8
3.4
5.84
5.83
kpa
0.02
70
516
5
15
3.35
1.52
1.0
1.2
—
—
—
0
0
69
525
1.35
1.51
3.8
3.4
2.45
1.91
mmol/l
0.53
61
430
6
21
2.87
1.51
4.8
5.4
—
—
—
0
0
7
28
2.52
1.45
1.1
1.3
—
—
—
0
0
7
28
2.52
1.45
1.1
1.3
—
—
—
0
0
568
5467
1.30
1.45
14.0
10.8
25.08
25.62
u/l
0.32
551
5265
63
476
1.36
1.45
2.7
2.3
33.00
32.00
u/l
0.12
57
403
192
1668
1.21
1.45
3.4
3.2
7.23
7.23
mmol/l
0.00
174
1395
12
59
2.05
1.44
3.0
1.9
—
—
—
0
0
30
197
1.55
1.43
2.5
2.9
—
—
—
0
0
585
5656
1.33
1.42
33.2
22.7
248.83
246.52
e9/l
0.33
578
5515
18
103
1.77
1.42
2.8
1.4
0.71
0.88
nmol/l
0.48
12
87
88
702
1.29
1.40
1.5
1.4
—
—
—
0
0
585
5658
1.32
1.40
33.1
22.7
4.35
4.44
e12/l
3.61
574
5499
585
5660
1.32
1.38
33.2
22.8
131.76
134.04
g/l
3.08
580
5570
108
887
1.26
1.37
2.6
2.4
11.29
12.64
umol/l
1.29
101
820
38
266
1.46
1.35
1.6
1.9
1.53
1.63
g/l
0.20
33
237
46
334
1.41
1.35
1.5
1.5
—
—
—
0
0
13
68
1.93
1.34
1.2
1.3
0.53
0.58
nmol/l
0.24
13
63
99
808
1.27
1.32
2.6
2.4
2.47
2.30
g/l
2.59
93
748
584
5655
1.31
1.31
33.0
22.7
39.35
39.79
%
0.86
521
5268
32
219
1.48
1.28
1.1
1.1
—
—
—
0
0
11
55
2.02
1.28
3.2
2.0
—
—
—
0
0
16
92
1.76
1.26
2.5
2.9
3.71
4.59
e9/l
0.77
16
92
6
25
2.41
1.24
1.5
1.4
—
—
—
0
0
222
1982
1.18
1.22
3.5
3.3
—
—
—
0
0
309
2836
1.17
1.21
2.7
2.8
—
—
—
0
0
59
456
1.32
1.20
3.6
2.7
4.20
4.40
kpa
0.39
59
437
93
766
1.25
1.16
2.7
2.4
19.37
22.11
%
1.06
66
646
23
150
1.55
1.16
1.2
1.4
291.23
282.37
ug/g
0.10
13
87
13
72
1.82
1.15
1.3
1.4
—
—
—
0
0
13
72
1.82
1.15
1.3
1.4
—
—
—
0
0
8
39
2.06
1.15
1.0
1.6
—
241.43
—
0
7
5
20
2.51
1.15
2.6
1.8
83.00
104.65
%
—
5
20
14
80
1.77
1.13
1.2
1.1
171.78
280.51
u/ml
—
9
42
124
1058
1.21
1.12
1.3
1.2
0.82
1.42
u/ml
1.30
30
279
44
329
1.36
1.12
4.2
3.6
2.26
1.83
mmol/l
0.24
33
243
13
73
1.80
1.11
1.3
1.4
—
—
—
0
0
16
96
1.68
1.11
2.4
1.6
—
—
—
0
0
7
32
2.20
1.08
1.6
2.0
0.25
0.23
e9/l
—
7
27
16
97
1.67
1.07
2.6
3.3
56.44
59.24
%
0.32
16
97
26
178
1.48
1.07
1.3
1.2
—
—
—
0
0
18
113
1.61
1.06
1.7
1.5
—
—
—
0
0
38
280
1.38
1.06
1.3
1.2
307.37
261.08
u/ml
0.09
33
255
7
33
2.13
1.06
2.0
1.3
131.14
170.51
pmol/l
—
7
33
190
1700
1.17
1.00
4.2
3.9
4.57
8.58
mg/mmol
2.01
130
1080
12
69
1.75
0.97
1.0
1.0
—
—
—
0
0
6
28
2.15
0.91
1.2
1.2
—
—
—
0
0
501
4824
1.16
0.90
7.4
6.1
40.72
40.26
mmol/mol
0.47
475
4453
162
1445
1.16
0.89
4.8
4.4
21.38
21.45
%
0.02
84
720
76
634
1.22
0.88
1.5
1.4
—
—
—
0
0
10
56
1.80
0.88
2.7
1.7
—
—
—
0
0
10
56
1.80
0.88
2.7
1.7
—
—
—
0
0
10
56
1.80
0.88
2.7
1.7
—
—
—
0
0
14
87
1.62
0.88
1.2
1.1
—
—
—
0
0
6
30
2.01
0.87
2.5
2.4
—
—
—
0
0
8
47
1.71
0.81
1.5
1.4
20.23
25.66
u/l
—
8
39
9
151
0.59
0.79
1.9
1.8
—
—
—
0
0
60
496
1.23
0.77
5.9
6.1
1.25
1.40
mmol/l
0.97
60
482
19
132
1.45
0.76
1.4
1.7
—
—
—
0
0
457
4396
1.13
0.74
25.3
18.4
15.68
15.22
%
0.75
451
4327
21
150
1.41
0.74
2.0
1.5
—
—
—
0
0
18
125
1.45
0.73
1.4
1.4
—
—
—
0
0
17
118
1.45
0.70
2.1
1.5
6.80
6.02
iu/l
—
7
33
19
136
1.41
0.67
1.6
1.4
—
—
—
0
0
5
29
1.73
0.64
1.6
1.5
—
—
—
0
0
5
29
1.73
0.64
1.6
1.5
—
—
—
0
0
22
165
1.34
0.61
2.4
1.8
2.34
2.94
mg/l
0.29
15
125
20
148
1.36
0.60
2.0
2.3
14.96
73.37
ug/min
2.13
11
82
0
23
0.00
0.58
0.0
1.3
—
—
—
0
0
17
123
1.39
0.58
1.5
1.3
—
—
—
0
0
17
123
1.39
0.58
1.5
1.3
—
—
—
0
0
6
35
1.72
0.58
1.2
1.3
—
—
—
0
0
150
1373
1.12
0.57
1.9
1.7
1.37
1.36
mmol/l
0.09
128
1137
6
36
1.67
0.57
1.2
2.3
13.83
13.27
%
—
6
36
5
86
0.58
0.56
1.2
1.5
—
—
—
0
0
6
37
1.63
0.55
3.2
2.8
—
—
—
0
0
42
350
1.21
0.54
1.7
1.7
—
—
—
0
0
517
5049
1.11
0.52
5.4
4.8
6.05
5.99
mmol/l
0.34
482
4557
6
41
1.47
0.50
1.3
1.4
—
—
—
0
0
20
154
1.31
0.49
1.8
1.6
—
—
—
0
0
21
163
1.30
0.49
1.6
1.8
—
—
—
0
0
7
48
1.46
0.47
1.9
1.5
—
—
—
0
0
8
117
0.68
0.46
1.3
1.1
—
—
—
0
0
14
103
1.37
0.45
1.4
1.3
2.11
12.95
e6/l
—
9
77
16
121
1.33
0.44
1.2
1.4
—
—
—
0
0
516
5056
1.10
0.42
5.1
4.6
4.47
4.59
mmol/l
1.78
484
4641
8
57
1.41
0.42
1.3
1.1
1.49
1.51
g/l
—
8
52
528
5180
1.10
0.42
5.8
5.1
2.57
2.69
mmol/l
2.44
496
4721
136
1266
1.09
0.39
2.6
2.3
—
—
—
0
0
5
37
1.35
0.37
1.6
1.1
—
—
—
0
0
495
4852
1.08
0.37
4.4
4.1
1.38
1.28
mmol/l
1.76
460
4395
5
80
0.62
0.35
1.2
1.1
—
—
—
0
0
6
43
1.40
0.35
1.5
1.1
—
—
—
0
0
6
89
0.67
0.33
1.0
1.3
—
—
—
0
0
37
422
0.87
0.32
2.0
2.8
54.88
63.72
ml/min/173m2
0.94
16
166
511
5026
1.08
0.31
4.9
4.5
1.44
1.47
mmol/l
0.67
477
4585
7
54
1.30
0.30
1.9
2.3
—
—
—
0
0
18
148
1.22
0.29
1.7
1.3
—
—
—
0
0
100
935
1.08
0.28
2.8
2.8
1.17
1.10
e6/l
0.11
64
533
5
71
0.70
0.26
1.0
1.1
—
—
—
0
0
186
1788
1.06
0.24
5.2
5.1
3.05
2.84
ug/l
0.16
164
1592
47
429
1.10
0.23
3.8
3.8
96.63
85.51
ng/l
0.34
40
378
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
22
191
1.16
0.22
2.9
2.5
0.39
0.35
u/ml
0.24
14
109
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
116
1104
1.06
0.21
3.5
3.1
2.46
2.45
mmol/l
0.08
101
968
61
567
1.08
0.21
5.4
3.6
—
—
—
0
0
6
50
1.20
0.19
1.3
1.1
—
—
—
0
0
6
52
1.16
0.19
1.5
1.3
—
—
—
0
0
17
147
1.16
0.18
1.8
1.8
—
—
—
0
0
7
59
1.19
0.18
4.1
3.9
—
—
—
0
0
14
120
1.17
0.16
1.2
1.4
—
—
—
0
0
162
1672
0.96
0.16
3.7
3.3
35.42
113.12
e6/l
1.16
131
1290
11
92
1.20
0.16
1.5
1.7
—
—
—
0
0
8
72
1.11
0.16
1.1
1.1
—
—
—
0
0
15
172
0.87
0.16
1.0
1.2
—
—
—
0
0
64
606
1.06
0.15
3.6
4.2
11.88
32.40
ug/l
0.76
54
516
15
171
0.87
0.15
1.0
1.2
—
—
—
0
0
12
104
1.16
0.12
2.7
2.5
13.17
15.75
%
—
6
47
12
137
0.87
0.12
1.1
1.2
—
—
—
0
0
32
343
0.93
0.11
2.0
1.8
—
—
—
0
0
20
183
1.10
0.10
1.2
1.5
1.28
1.17
g/l
0.97
20
173
5
46
1.09
0.09
1.6
1.1
—
—
—
0
0
5
47
1.06
0.09
1.4
1.4
—
—
—
0
0
5
48
1.04
0.09
1.6
1.1
—
—
—
0
0
119
1161
1.03
0.09
2.9
2.6
6.49
5.69
e6/l
0.20
104
1040
6
58
1.03
0.08
1.3
1.4
—
—
—
0
0
7
66
1.06
0.08
1.9
1.6
—
—
—
0
0
155
1523
1.02
0.07
3.4
3.2
0.71
0.54
e6/l
0.30
125
1146
102
1044
0.97
0.07
3.3
3.0
0.71
0.80
ug/l
0.59
71
694
10
112
0.89
0.07
1.2
1.3
—
—
—
0
0
487
4845
1.02
0.06
17.4
14.5
76.94
77.20
ml/min/173m2
0.09
415
4010
24
254
0.94
0.06
1.1
1.3
—
—
—
0
0
37
357
1.04
0.04
2.5
1.8
—
—
—
0
0
89
875
1.02
0.04
3.1
3.0
4.44
2.46
e6/l
0.65
53
480
16
168
0.95
0.02
1.5
1.6
—
—
—
0
0
33
322
1.03
0.02
2.7
1.7
—
—
—
0
0
14
133
1.05
0.01
1.2
1.2
—
—
—
0
0
14
134
1.05
0.00
1.0
1.1
—
13.59
—
0
14
68
686
0.99
0.00
4.7
4.5
32.42
32.57
%
0.04
53
461
18
176
1.02
0.00
1.2
1.5
0.29
0.23
g/l
1.76
18
167
27
266
1.02
0.00
2.7
3.4
24.66
24.01
mmol/l
0.34
27
259
46
462
1.00
0.00
3.9
3.5
1.22
1.23
mmol/l
0.52
38
402
6
61
0.98
-0.00
1.0
1.0
—
2.58
—
0
26
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
6.7
—
7.28
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
51
0.98
-0.00
3.4
2.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
6
65
0.92
-0.00
1.0
1.1
103.67
116.18
%
—
6
60
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.9
—
0.57
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
67
0.89
-0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
14.49
—
0
8
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.0
—
83.96
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
112.20
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_PERCHRONDR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_PERCHRONDR | 1.613 [1.35, 1.93] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.2 |
During the follow-up period (1.1.1998 — 31.12.2019), 337 out of 1198 females with H8_PERCHRONDR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_PERCHRONDR | 1.223 [1.0, 1.49] | 0.046 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 259 out of 924 males with H8_PERCHRONDR died.
Mortality risk
Mortality risk for people of age
years, who have H8_PERCHRONDR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.155% | 0.181% |
| 5 | 1.027% | 1.238% |
| 10 | 2.192% | 3.306% |
| 15 | 4.13% | 6.583% |
| 20 | 7.925% | 10.866% |
Relationships between endpoints
↥Index endpoint: H8_PERCHRONDR – Perichondritis of external ear
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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