cerebral atherosclerosis: Vascular diseases characterized by thickening and hardening of the walls of ARTERIES inside the SKULL. There are three subtypes: (1) atherosclerosis with fatty deposits in the ARTERIAL INTIMA; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include HEADACHE; CONFUSION; transient blindness (AMAUROSIS FUGAX); speech impairment; and HEMIPARESIS.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
506 |
4. Check minimum number of eventsNone |
506 |
5. Include endpointsNone |
506 |
6. Filter based on genotype QC (FinnGen only) |
494 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- I67
- Name in latin
- Atherosclerosis cerebralis
Similar endpoints
↥List of similar endpoints to
Cerebral atherosclerosis
based on the number of shared cases.
Similar with more cases:
- Cerebrovascular diseases (FINNGEN)
- Cerebrovascular diseases
- Neurological diseases, wide definition
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13448 | 6688 | 6394 |
| Only index persons | 3338 | 1814 | 1524 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.19 | 0.18 |
| Only index persons | 0.06 | 0.07 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 76.04 | 77.52 | 74.70 |
| Only index persons | 76.30 | 78.24 | 74.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 494 | 187 | 307 |
| Unadjusted period prevalence (%) | 0.11 | 0.07 | 0.14 |
| Median age at first event (years) | 73.87 | 73.82 | 73.91 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 505
- Matched controls
- 5034
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I67.2
ICD-10 Finland
Cerebral atherosclerosis
8309.0
307.7
425
*
4370A
ICD-9 Finland
Other and ill-defined cerebrovascular disease, Cerebral atherosclerosis
+∞
43.3
41
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
4.3
41.0
131
380
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
9.5
34.9
43
49
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
7.5
34.9
53
78
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
4.3
33.3
100
274
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.4
32.5
150
551
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
3.8
30.6
109
337
AA1AD
NOMESCO Finland
CT of head and brain
2.7
25.1
208
1038
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
7.1
24.5
38
57
B01AC04
ATC
clopidogrel; oral
2.8
23.5
158
704
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
4.2
20.5
58
150
PA6AD
NOMESCO Finland
CT of neck arteries
7.1
20.1
31
46
43799
ICD-8 Finland
Generalised ischaemic cerebrovascular disease, Without mention of hypertension
+∞
19.9
19
*
43700
ICD-8 Finland
Generalised ischaemic cerebrovascular disease, With hypertension (benign)
+∞
19.9
19
*
XA800
NOMESCO Finland
Neuropsychological investigation
6.6
18.1
30
48
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
7.5
17.9
26
36
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
4.2
16.8
46
116
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
4.9
16.5
38
83
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.7
16.3
56
166
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
3.7
16.0
54
158
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
6.3
15.2
26
43
PAN14
NOMESCO Finland
Plastic repair of arteries internal carotid artery
15.2
13.7
22
15
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
4.5
12.8
32
75
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.6
12.2
79
337
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.4
12.0
45
141
F01.9
ICD-10 Finland
Vascular dementia, unspecified
4.1
11.9
33
84
C10AA05
ATC
atorvastatin; oral
1.9
11.2
240
1623
5541
FHL
Subclavia and / or carotid endarterectomy, reconstruction or bypass surgery
22.0
10.7
15
7
B01AC07
ATC
dipyridamole; systemic
2.4
9.7
69
306
R53
ICD-10 Finland
Malaise and fatigue
1.9
9.6
145
865
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.3
9.6
80
382
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
5.0
9.3
20
41
N06AX16
ATC
venlafaxine; oral
2.6
8.7
53
218
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.7
8.6
47
183
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.8
8.4
188
1260
I67.3
ICD-10 Finland
Progressive vascular leukoencephalopathy
4.6
8.4
20
45
PEF23
NOMESCO Finland
Thrombendarterectomy of femoral artery
5.0
8.4
18
37
R42
ICD-10 Finland
Dizziness and giddiness
1.9
8.3
134
813
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.0
8.0
90
482
205
Kela drug reimbursment
Chronic hypertension
1.7
8.0
205
1425
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.8
7.7
39
146
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
7.7
93
511
H53.1
ICD-10 Finland
Subjective visual disturbances
3.0
7.5
33
114
R51.80
ICD-10 Finland
Headache
2.2
7.4
65
316
A28
ICPC
Limited function/disability NOS
1.8
7.4
128
791
C10AA01
ATC
simvastatin; oral
1.7
7.2
266
2021
K90
ICPC
Stroke/cerebrovascular accident
3.2
7.1
28
91
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
7.0
118
721
G45.3
ICD-10 Finland
Amaurosis fugax
3.8
6.9
21
57
C08CA01
ATC
amlodipine; oral
1.7
6.9
217
1576
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.8
6.8
130
824
R4120
NOMESCO Finland
Occupational therapy
2.7
6.8
36
138
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
40.5
6.8
8
*
P76
ICPC
Depressive disorder
4.0
6.7
19
49
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.0
6.4
68
356
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.0
6.4
72
385
WX892
NOMESCO Finland
Monitored bed care
2.4
6.4
44
193
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.7
6.3
128
825
315
Kela drug reimbursment
Clopidogrel
3.9
6.3
18
47
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.2
6.2
24
77
TPH07
NOMESCO Finland
Cathetrisation of artery
2.0
6.2
67
353
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
6.1
184
1313
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
5.6
6.0
16
29
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
200
1146
2.22
16.19
3.0
2.0
201.84
318.29
u/l
0.76
193
1065
106
591
2.00
8.45
2.5
3.0
0.80
0.82
mmol/l
1.16
95
545
238
1731
1.70
7.81
7.5
5.5
1.20
1.21
mmol/l
1.50
224
1547
251
1887
1.65
7.00
7.8
6.3
1.20
1.21
mmol/l
1.09
202
1563
124
774
1.79
6.87
5.5
4.0
433.47
219.79
ng/l
0.26
110
680
216
1596
1.61
6.25
2.5
2.1
92.38
90.64
pmol/l
0.23
125
833
146
983
1.68
6.09
1.8
1.6
20.19
20.38
nmol/l
0.05
130
821
83
487
1.84
5.56
7.1
5.1
1.01
1.05
mmol/l
0.81
78
437
110
704
1.71
5.48
1.9
1.8
—
—
—
0
0
92
579
1.71
4.84
3.2
2.4
2.20
2.24
g/l
0.24
82
530
267
2160
1.49
4.68
8.1
4.7
7.13
6.89
mmol/l
0.84
254
2038
95
623
1.64
4.26
3.3
2.4
10.00
11.84
umol/l
2.03
86
575
127
893
1.56
4.26
1.8
1.8
1048.43
1178.28
nmol/l
0.98
97
655
178
1346
1.49
4.25
3.6
2.7
113.57
159.69
ug/l
3.41
167
1201
79
494
1.70
4.24
1.9
1.7
—
—
—
0
0
78
494
1.68
4.00
1.9
1.8
—
—
—
0
0
141
1032
1.50
3.90
2.8
2.1
2.80
3.32
mg/l
2.14
128
866
190
1483
1.44
3.77
6.3
5.2
60.17
59.17
%
0.58
182
1379
243
1991
1.42
3.66
20.1
19.8
1.29
1.41
inr
1.50
80
571
227
1841
1.42
3.60
3.7
3.0
54.30
55.45
u/l
0.06
218
1669
83
555
1.59
3.43
3.3
2.4
18.90
20.98
%
0.60
60
477
206
1654
1.41
3.41
5.8
4.3
33.42
34.32
g/l
1.32
193
1520
56
339
1.73
3.39
4.8
3.8
1.23
1.22
mmol/l
0.55
50
285
39
211
1.91
3.38
1.6
1.6
1.89
1.65
%
0.50
33
173
16
59
2.76
3.33
1.3
1.1
7.11
14.47
e6/l
—
9
49
16
59
2.76
3.33
1.4
1.2
4.70
1913.90
e6/l
—
10
50
196
1573
1.40
3.21
3.1
2.7
—
—
—
0
0
61
387
1.65
3.12
3.7
3.1
232.46
274.44
ng/l
0.34
52
357
62
397
1.63
3.06
3.7
3.8
2.76
2.03
mmol/l
0.86
53
319
63
406
1.62
3.03
2.7
2.7
5.72
9.31
umol/l
3.14
55
355
188
1512
1.38
3.00
6.8
5.4
25.46
25.18
%
0.13
180
1406
35
192
1.88
2.94
4.7
4.1
25.41
24.08
mmol/l
1.44
30
186
61
399
1.60
2.77
3.9
3.8
5.94
5.84
kpa
0.26
56
384
226
1891
1.35
2.74
5.6
5.8
11.50
12.37
umol/l
0.75
214
1778
71
484
1.54
2.70
8.8
6.0
1.24
1.30
mmol/l
0.05
64
377
153
1212
1.37
2.62
4.2
3.6
35.54
139.64
e6/l
1.23
113
956
54
348
1.61
2.61
1.9
2.1
0.21
0.20
g/l
0.17
48
316
7
15
4.70
2.60
1.0
1.0
437.14
149.93
u/l
—
7
15
28
150
1.91
2.54
2.3
2.0
550.38
787.72
ug/l
0.24
28
141
15
63
2.42
2.47
1.3
1.2
475.20
523.42
mg/l
0.27
15
57
14
57
2.49
2.45
2.6
1.9
—
—
—
0
0
48
307
1.62
2.41
2.1
1.7
—
—
—
0
0
64
439
1.52
2.38
5.8
3.9
—
—
—
0
0
13
52
2.53
2.36
1.0
1.2
—
—
—
0
0
128
1004
1.36
2.31
3.5
2.9
43.27
36.90
u/l
0.27
117
960
271
2366
1.31
2.31
6.9
5.1
14.67
4050.97
e6/l
—
6
58
11
40
2.78
2.27
1.3
1.3
0.75
0.51
nmol/l
1.30
11
34
218
1854
1.30
2.24
7.4
8.1
4.57
4.38
e9/l
0.46
191
1615
199
1674
1.31
2.21
5.0
4.2
0.02
0.00
estimate
0.49
49
357
193
1620
1.30
2.17
5.8
4.3
106.66
40.31
ng/l
0.70
159
1276
34
205
1.70
2.15
1.5
1.9
1.60
1.65
g/l
0.12
28
180
21
109
1.96
2.12
1.6
1.4
—
—
—
0
0
198
1673
1.30
2.10
6.8
5.6
0.00
0.00
estimate
-0.00
45
319
172
1427
1.31
2.09
2.7
2.2
—
—
—
0
0
40
254
1.62
2.09
1.9
1.5
—
—
—
0
0
48
319
1.55
2.07
2.6
2.3
28.61
31.84
u/l
0.36
41
255
199
1693
1.28
1.98
5.0
4.2
0.02
0.00
estimate
0.49
43
310
112
882
1.34
1.95
1.9
1.8
438.79
8178341.94
pmol/l
0.50
94
697
5
11
4.56
1.94
1.0
1.0
—
—
—
0
0
18
96
1.90
1.71
1.1
1.3
—
—
—
0
0
18
96
1.90
1.71
1.1
1.3
—
—
—
0
0
49
344
1.47
1.67
2.7
3.0
4.58
4.21
kpa
0.65
44
327
132
1088
1.28
1.65
4.0
3.4
0.79
0.59
e6/l
0.23
96
840
25
150
1.70
1.65
3.2
3.0
—
—
—
0
0
261
2331
1.24
1.63
4.1
3.7
14.70
15.10
pmol/l
1.88
241
2026
29
440
0.64
1.58
8.5
8.3
—
—
—
0
0
161
1366
1.26
1.58
2.5
2.2
79.53
78.90
nmol/l
0.11
149
1180
165
1406
1.25
1.56
3.9
3.5
—
—
—
0
0
40
275
1.49
1.53
1.9
1.7
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
24
147
1.66
1.48
4.3
2.2
0.33
0.33
u/ml
0.02
17
79
15
80
1.90
1.45
4.3
1.6
—
—
—
0
0
25
157
1.62
1.42
1.3
1.3
—
40.89
—
0
13
39
274
1.45
1.36
2.5
3.8
5.03
5.13
kpa
0.32
39
263
5
17
2.95
1.35
4.2
5.6
—
—
—
0
0
271
2460
1.21
1.35
5.0
4.0
14.47
15.42
mm/h
0.46
260
2220
5
18
2.79
1.28
5.0
3.8
211.00
241.78
u/l
—
5
18
60
460
1.34
1.28
1.2
1.2
18.46
41.17
iu/ml
1.92
20
145
10
49
2.06
1.21
3.0
4.0
—
—
—
0
0
60
465
1.32
1.20
3.4
3.6
222.29
249.82
u/l
2.12
55
435
6
26
2.32
1.18
1.0
1.0
—
—
—
0
0
35
249
1.43
1.16
2.4
4.0
1.31
1.96
mmol/l
0.65
30
184
5
20
2.51
1.15
1.0
1.0
—
—
—
0
0
17
103
1.67
1.13
1.2
1.2
—
—
—
0
0
17
103
1.67
1.13
1.2
1.2
—
—
—
0
0
77
624
1.27
1.11
3.4
3.4
5.96
2.19
e6/l
0.44
34
371
40
297
1.37
1.06
4.4
3.8
92.65
89.57
ng/l
0.08
34
260
287
2656
1.18
1.05
8.4
7.2
77.08
81.34
u/l
0.97
271
2463
70
565
1.27
1.05
1.3
1.2
0.92
1.16
u/ml
0.39
14
147
145
1275
1.19
0.97
2.9
3.2
2.35
2.34
mmol/l
0.08
133
1106
94
794
1.22
0.96
2.7
3.1
2.47
2.46
mmol/l
0.35
81
693
36
271
1.35
0.90
2.3
3.0
59.69
56.91
ml/min/173m2
0.19
13
119
21
143
1.48
0.90
1.1
1.3
—
—
—
0
0
11
63
1.76
0.90
3.9
2.7
3.91
4.87
e9/l
0.79
11
63
6
29
2.07
0.89
1.0
1.1
—
—
—
0
0
158
1414
1.17
0.85
3.3
3.2
2297.33
2144.88
ng/l
0.12
139
1230
93
796
1.20
0.84
1.7
1.6
1.32
1.29
mmol/l
0.14
76
636
8
47
1.71
0.80
1.1
5.2
—
166.80
—
0
5
6
33
1.82
0.79
1.0
1.0
—
—
u/ml
—
0
0
6
33
1.82
0.79
1.2
1.2
—
—
—
0
0
0
26
0.00
0.78
0.0
1.2
—
146.00
—
0
7
309
2915
1.15
0.77
5.6
4.6
2.17
2.04
mu/l
0.71
288
2556
76
644
1.21
0.77
3.5
3.1
0.87
1.17
e6/l
0.63
33
385
10
59
1.70
0.75
1.1
1.2
16.50
57.57
u/l
—
10
49
11
67
1.65
0.75
4.8
3.2
52.09
60.45
%
1.51
11
67
5
25
2.00
0.72
1.0
1.0
—
—
—
0
0
9
56
1.61
0.72
1.2
1.2
0.69
0.80
nmol/l
—
9
45
96
837
1.18
0.71
2.8
2.5
—
—
—
0
0
23
169
1.37
0.69
1.7
2.0
—
—
—
0
0
85
737
1.18
0.68
5.1
4.8
1.01
1.02
kg/l
0.54
22
116
18
127
1.43
0.68
1.2
1.3
—
—
—
0
0
107
947
1.16
0.67
5.6
4.5
0.00
0.00
estimate
-0.00
43
309
16
111
1.45
0.65
1.4
1.5
—
—
—
0
0
15
103
1.47
0.65
2.1
2.5
14.75
77.51
ug/min
—
8
64
8
126
0.63
0.64
1.8
1.9
—
—
—
0
0
47
387
1.23
0.64
2.1
2.6
4.96
6.08
ug/l
0.39
40
332
103
916
1.15
0.61
3.2
2.8
4450.21
8258.71
umol/l
0.40
91
764
21
276
0.75
0.61
1.4
1.3
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
83
733
1.15
0.54
1.9
1.7
1.00
1.50
mg/l
2.75
70
584
336
3227
1.11
0.52
25.8
18.0
25.82
28.27
mg/l
0.72
305
2670
9
65
1.39
0.50
1.0
1.0
—
17.18
—
0
6
143
1327
1.10
0.43
5.6
4.5
—
—
—
0
0
20
157
1.28
0.43
4.2
2.8
1.75
1.44
mmol/l
0.36
20
152
117
1076
1.11
0.42
3.5
3.1
7.41
7.06
mmol/l
0.40
96
869
5
33
1.52
0.41
1.0
1.1
—
37.67
—
0
6
5
34
1.47
0.40
1.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
5
35
1.43
0.39
1.8
2.5
583.00
529.36
ml
—
5
22
5
77
0.64
0.36
1.6
1.5
1.19
2.06
mg/l
—
5
59
9
125
0.71
0.35
1.3
2.6
34.88
39.53
u/ml
—
9
119
80
863
0.91
0.30
2.9
3.2
0.88
0.84
ug/l
0.07
63
604
122
1146
1.08
0.29
4.2
3.7
12.64
9.80
mg/mmol
0.22
87
725
10
78
1.28
0.24
1.6
1.4
—
—
—
0
0
308
3004
1.06
0.22
7.4
6.5
42.23
41.58
mmol/mol
0.51
298
2732
305
3106
0.95
0.22
5.9
5.0
6.30
6.15
mmol/l
1.04
284
2745
5
42
1.19
0.21
1.0
2.1
—
—
—
0
0
5
42
1.19
0.21
1.2
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
92.70
—
0
10
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
8.61
—
0
7
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
2.6
—
2.27
—
0
7
18
154
1.17
0.20
2.3
4.7
23.68
25.14
mmol/l
1.60
18
144
0
14
0.00
0.20
0.0
1.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
10
80
1.25
0.20
1.4
1.5
—
—
—
0
0
6
50
1.20
0.19
1.0
1.2
—
—
—
0
0
6
52
1.15
0.19
1.2
1.5
—
—
—
0
0
6
52
1.15
0.19
1.2
1.5
—
—
—
0
0
41
444
0.91
0.18
2.8
4.1
2.73
35.07
ug/l
1.18
35
383
14
119
1.18
0.17
1.1
1.0
—
—
—
0
0
5
67
0.74
0.17
2.2
1.7
37.60
45.45
nmol/l
—
5
62
5
69
0.72
0.17
1.0
1.3
—
—
—
0
0
13
111
1.17
0.15
1.5
1.4
—
—
—
0
0
9
82
1.10
0.15
1.3
1.5
—
—
—
0
0
11
94
1.17
0.12
1.3
1.3
—
—
—
0
0
332
3349
0.97
0.12
13.2
10.8
25.42
24.20
u/l
0.63
321
3191
5
44
1.13
0.10
1.2
1.6
—
—
—
0
0
5
44
1.13
0.10
1.2
1.6
—
—
—
0
0
5
44
1.13
0.10
1.2
1.6
—
—
—
0
0
5
44
1.13
0.10
1.2
1.5
—
—
—
0
0
5
45
1.11
0.10
1.2
1.6
—
—
—
0
0
5
46
1.08
0.09
1.2
1.3
—
—
—
0
0
293
2887
1.03
0.09
5.2
4.2
1.32
1.24
mmol/l
0.59
281
2550
344
3461
0.97
0.09
37.4
26.2
128.98
131.83
g/l
2.93
337
3377
5
47
1.06
0.09
1.2
1.4
—
—
—
0
0
344
3460
0.97
0.09
37.7
26.1
37.64
38.98
%
2.10
314
3164
344
3460
0.97
0.09
37.1
26.0
4.29
4.36
e12/l
1.57
329
3327
19
174
1.09
0.09
1.9
1.7
—
—
—
0
0
344
3459
0.97
0.08
37.1
26.0
242.04
236.35
e9/l
0.78
329
3346
6
56
1.07
0.08
1.5
1.6
—
—
—
0
0
17
155
1.10
0.08
1.9
1.6
—
—
—
0
0
119
1212
0.97
0.08
4.7
4.6
21.99
21.43
%
0.15
55
638
8
74
1.08
0.07
2.5
1.4
—
—
—
0
0
301
3022
0.98
0.05
5.8
4.7
4.05
4.38
mmol/l
6.69
289
2714
343
3402
1.02
0.04
32.2
21.4
139.15
139.59
mmol/l
2.20
335
3291
152
1532
0.98
0.04
5.0
5.3
2.49
4.09
ug/l
1.11
135
1329
298
2986
0.99
0.03
5.7
4.7
1.38
1.43
mmol/l
1.26
284
2655
343
3406
1.01
0.02
32.7
21.5
4.01
4.02
mmol/l
0.22
335
3294
299
2970
1.01
0.02
25.3
17.4
70.33
70.59
ml/min/173m2
0.07
257
2483
312
3120
0.99
0.01
6.6
5.3
2.24
2.52
mmol/l
6.68
304
2782
11
114
0.96
0.00
2.3
3.0
0.74
0.92
nmol/l
—
5
90
42
424
0.99
0.00
1.4
1.2
0.88
14.87
u/ml
2.85
11
143
25
246
1.01
0.00
1.4
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
62
0.96
0.00
1.3
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
0.00
0.0
1.0
—
119.00
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
13.67
—
0
7
6
66
0.91
-0.00
1.3
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
59
1.01
-0.00
1.3
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
85
0.94
-0.00
1.3
1.6
—
—
—
0
0
5
55
0.91
-0.00
1.4
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
88
0.90
-0.00
1.3
1.6
—
—
—
0
0
5
54
0.92
-0.00
1.4
1.6
—
—
—
0
0
5
59
0.84
-0.00
1.4
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
9.56
—
0
9
5
53
0.94
-0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint I9_CEREBATHER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CEREBATHER | 2.047 [1.71, 2.45] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.133 |
During the follow-up period (1.1.1998 — 31.12.2019), 756 out of 1228 females with I9_CEREBATHER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CEREBATHER | 2.466 [1.9, 3.21] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 656 out of 1080 males with I9_CEREBATHER died.
Mortality risk
Mortality risk for people of age
years, who have I9_CEREBATHER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.185% | 0.353% |
| 5 | 1.028% | 2.747% |
| 10 | 2.745% | 6.72% |
| 15 | 5.394% | 11.925% |
| 20 | 9.426% | 19.076% |
Relationships between endpoints
↥Index endpoint: I9_CEREBATHER – Cerebral atherosclerosis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data