extrinsic allergic alveolitis: An inflammatory interstitial lung disease caused by hypersensitivity reaction to inhalation or ingestion of antigens. The antigens are usually related to the patient's occupation. It can present as an acute illness with flu-like symptoms, subacute with repeated episodes of pneumonia, or chronic with dyspnea and productive cough. The majority of patients recover following the cessation of the exposure to the antigen that causes the disease. Chronic exposure may eventually progress to interstitial lung fibrosis.
Hypersensitivity pneumonitis due to organic dust
DOID EFO Endpoint Browser PheWeb
J10_HYPERSPNEUMONI
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
582 |
4. Check minimum number of eventsNone |
582 |
5. Include endpointsNone |
582 |
6. Filter based on genotype QC (FinnGen only) |
582 |
Control definitions (FinnGen only)
- Control exclude
- J10_EXTERLUNG
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- J60-J70
- Name in latin
- Pneumonitis/alveolitis hypersensitiva e pulvere organico
Similar endpoints
↥List of similar endpoints to
Hypersensitivity pneumonitis due to organic dust
based on the number of shared cases.
Similar with more cases:
- Lung diseases due to external agents
- Diagnoses used for exclusion with ILD
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5824 | 2873 | 2887 |
| Only index persons | 4602 | 2341 | 2261 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.09 | 0.09 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 52.93 | 53.15 | 52.37 |
| Only index persons | 49.96 | 50.96 | 48.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 582 | 301 | 281 |
| Unadjusted period prevalence (%) | 0.11 | 0.10 | 0.12 |
| Median age at first event (years) | 49.81 | 47.62 | 52.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 533
- Matched controls
- 5329
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J67.0
ICD-10 Finland
Farmer lung
+∞
192.7
173
*
J67.9
ICD-10 Finland
Hypersensitivity pneumonitis due to unspecified organic dust
+∞
170.2
154
*
4950A
ICD-9 Finland
Extrinsic allergic alveolitis, Farmers' lung
+∞
114.8
106
*
4959X
ICD-9 Finland
Extrinsic allergic alveolitis, Unspecified allergic alveolitis and pneumonitis
+∞
90.2
84
*
H02AB06
ATC
prednisolone; systemic
3.6
43.3
343
1772
TGC00
NOMESCO Finland
Bronchial lavation
13.3
42.3
76
66
J67.8
ICD-10 Finland
Hypersensitivity pneumonitis due to other organic dusts
+∞
40.1
38
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
5.5
33.6
108
235
J45.9
ICD-10 Finland
Asthma, unspecified
3.6
29.1
155
543
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
9.3
28.1
60
72
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
13.1
26.0
46
38
51610
ICD-8 Finland
Other pneumoconiosis and related diseases, Due to inhalation of other dust
+∞
25.2
24
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
6.5
25.2
68
117
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
4.3
25.0
102
280
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
11.6
24.1
45
42
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
5.5
22.9
71
145
J45.1
ICD-10 Finland
Nonallergic asthma
4.6
21.5
80
199
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.9
21.4
153
644
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
52.3
21.3
25
5
R03AC02
ATC
salbutamol; inhalant
2.2
17.7
309
2036
R06.0
ICD-10 Finland
Dyspnoea
2.5
17.7
175
874
XG410
NOMESCO Finland
Flow-volume spirometry
5.1
16.7
54
116
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
6.4
16.6
44
74
J45.0
ICD-10 Finland
Predominantly allergic asthma
3.5
16.1
79
251
1240
FHL
Bronchoscopy
15.1
16.0
26
18
J01FA06
ATC
roxithromycin; oral
2.2
16.0
248
1523
4958X
ICD-9 Finland
Extrinsic allergic alveolitis, Other specified allergic alveolitis and pneumonitis
+∞
15.7
15
*
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
11.3
15.2
28
26
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
15.0
163
841
R03BA01
ATC
beclometasone; inhalant
2.7
14.6
107
446
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
11.4
13.1
24
22
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.7
13.1
99
420
J67.2
ICD-10 Finland
Bird fancier lung
+∞
12.5
12
*
J67.1
ICD-10 Finland
Bagassosis
+∞
12.5
12
*
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
13.8
12.0
20
15
4779A
ICD-9 Finland
Allergic rhinitis, Cause unspecified
19.5
11.7
17
9
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
23.5
11.6
16
7
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
9.9
11.3
22
23
J47
ICD-10 Finland
Bronchiectasis
7.9
11.3
25
33
J66.8
ICD-10 Finland
Airway disease due to other specific organic dusts
+∞
10.4
10
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.9
10.1
65
247
4931A
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA SINE EXACERBATIONE]
12.5
9.9
17
14
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
9.7
248
1732
L04AX01
ATC
azathioprine; systemic
4.0
9.7
38
100
R03BA02
ATC
budesonide; inhalant
2.2
9.6
110
570
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
5.4
9.3
27
52
R03AC12
ATC
salmeterol; inhalant
3.5
9.3
42
126
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.8
9.2
61
238
7860A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Dyspnoea and respiratory abnormalities[DYSPNOEA]
12.8
8.9
15
12
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
14.3
8.7
14
10
GD1AD
NOMESCO Finland
Thorax CT examination
3.6
8.5
37
108
Z94.2
ICD-10 Finland
Lung transplant status
91.5
8.4
9
*
A41.9
ICD-10 Finland
Sepsis, unspecified
3.9
8.1
32
86
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.0
8.0
45
158
R50.9
ICD-10 Finland
Fever, unspecified
2.2
7.9
84
420
GDA10
NOMESCO Finland
Biopsy of lung
45.7
7.7
9
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
7.3
120
708
J67.7
ICD-10 Finland
Air-conditioner and humidifier lung
+∞
7.3
7
*
51620
ICD-8 Finland
Other pneumoconiosis and related diseases, Due to inhalation of fumes
+∞
7.3
7
*
R03BB04
ATC
tiotropium bromide; inhalant
2.3
7.1
68
322
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.1
7.0
36
120
R03AC03
ATC
terbutaline; inhalant
2.1
7.0
82
425
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
5.8
6.8
18
32
R03DA04
ATC
theophylline; systemic, rectal
3.0
6.7
36
124
J45.8
ICD-10 Finland
Mixed asthma
3.5
6.6
29
86
GDG10
NOMESCO Finland
Bilateral transplantation of lung
70.7
6.4
7
*
XG404
NOMESCO Finland
Peak expiratory flow (PEF) measurement
10.2
6.1
11
11
J01MA14
ATC
moxifloxacin; systemic
2.2
6.0
59
284
R05
ICD-10 Finland
Cough
1.8
6.0
100
593
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
49
50
10.61
43.30
2.4
1.7
—
—
—
0
0
87
175
5.67
42.32
3.3
2.8
—
—
—
0
0
96
273
4.01
30.17
1.8
1.2
145.2
152.9
u/ml
0.05
85
242
33
38
9.15
26.52
1.5
1.2
0.1
0.1
u/ml
0.24
20
18
48
89
5.79
25.19
2.4
1.5
—
—
—
0
0
39
70
5.90
21.13
2.5
1.5
—
—
—
0
0
51
117
4.68
21.02
2.5
1.7
—
—
—
0
0
23
22
10.84
21.01
2.5
1.5
—
—
—
0
0
129
550
2.73
20.38
6.2
7.9
1.1
1.2
mmol/l
0.16
104
438
129
554
2.71
20.07
6.2
7.8
5.0
5.1
kpa
0.35
123
531
129
555
2.70
19.99
6.2
7.8
10.3
12.2
kpa
4.67
124
532
50
121
4.43
19.27
2.5
1.7
—
—
—
0
0
46
118
4.15
16.42
2.6
1.4
—
—
—
0
0
82
315
2.87
15.57
6.7
7.1
24.9
24.5
mmol/l
0.46
77
296
20
24
8.59
15.46
1.9
2.1
—
—
—
0
0
53
159
3.57
15.16
1.8
1.6
700.0
163.3
titre
—
6
6
20
26
7.93
14.50
1.8
2.0
17.2
14.8
%
0.20
12
14
36
86
4.40
14.08
2.7
1.8
—
—
—
0
0
28
54
5.40
14.04
3.1
1.5
—
—
—
0
0
37
91
4.27
13.94
1.3
1.2
—
—
—
0
0
30
70
4.46
12.08
1.9
1.5
—
—
—
0
0
32
79
4.23
12.00
1.9
1.5
—
—
—
0
0
12
11
11.12
11.09
1.3
1.2
—
—
—
0
0
29
71
4.25
10.99
2.9
1.5
—
—
—
0
0
28
70
4.15
10.34
1.2
1.1
—
—
—
0
0
218
1463
1.78
9.78
3.7
3.2
1195.3
1423.2
ng/l
0.39
198
1251
354
2740
1.75
9.48
13.3
9.2
4.5
4.1
e9/l
2.02
332
2410
32
96
3.47
9.16
20.3
7.2
268.3
209.5
iu/ml
0.18
14
16
40
140
2.99
8.93
2.2
2.2
10.7
12.2
mg/l
0.48
40
130
13
18
7.36
8.88
4.8
5.8
—
—
—
0
0
16
29
5.64
8.54
2.1
2.0
0.2
0.2
e9/l
0.01
16
24
61
280
2.32
7.95
7.6
3.9
2.3
1.7
mmol/l
0.60
48
220
22
56
4.04
7.95
1.6
2.1
—
—
—
0
0
186
1258
1.70
7.77
5.4
3.9
0.0
0.0
estimate
0.69
54
419
39
147
2.77
7.64
1.8
1.8
—
—
—
0
0
132
815
1.80
7.57
1.4
1.3
31.8
37.7
iu/ml
0.26
42
271
15
30
5.11
7.22
2.3
1.3
—
—
—
0
0
158
1040
1.71
7.22
5.6
4.0
1.0
1.0
kg/l
0.17
19
140
19
48
4.06
6.94
1.2
1.1
—
—
—
0
0
12
20
6.11
6.93
3.7
1.8
32.0
58.2
ug/l
1.80
12
20
20
53
3.87
6.86
1.2
1.5
—
—
—
0
0
20
53
3.87
6.86
1.7
2.2
—
—
—
0
0
35
133
2.74
6.77
1.7
1.5
—
—
—
0
0
128
812
1.74
6.62
2.7
1.9
—
—
—
0
0
33
131
2.61
5.89
5.4
2.4
25.5
25.0
mmol/l
0.29
33
111
413
3532
1.58
5.83
7.1
4.1
13.8
12.5
mm/h
0.91
392
3241
10
9
11.28
5.81
4.4
1.7
—
—
—
0
0
236
1799
1.52
5.62
5.2
3.8
—
—
—
0
0
68
380
1.89
5.30
2.7
2.7
66.7
63.8
ml/min/173m2
0.25
33
159
380
4310
0.66
5.18
23.4
15.7
38.1
40.0
%
1.97
234
3043
201
1505
1.51
5.10
3.0
2.4
60.0
55.9
u/l
0.41
191
1406
297
2409
1.48
5.05
8.8
6.8
1.2
1.2
mmol/l
0.28
261
2045
27
107
2.60
4.86
8.7
2.6
8.0
8.0
kpa
0.04
27
97
11
24
4.65
4.80
2.8
1.3
—
—
—
0
0
23
85
2.78
4.73
1.5
1.2
—
—
—
0
0
11
25
4.47
4.58
2.8
1.3
—
—
—
0
0
90
573
1.68
4.52
2.8
1.8
—
—
—
0
0
273
2212
1.44
4.49
7.9
5.9
1.2
1.2
mmol/l
0.95
261
2005
50
268
1.95
4.42
3.4
2.7
0.2
0.2
e6/l
0.03
50
260
89
572
1.66
4.31
2.7
1.8
—
—
—
0
0
26
108
2.47
4.28
1.2
1.4
—
—
—
0
0
12
31
3.93
4.27
1.4
1.2
—
—
—
0
0
192
1469
1.46
4.23
4.5
3.1
137.5
103.9
e6/l
0.13
165
1126
13
36
3.67
4.22
2.5
1.4
—
—
—
0
0
223
1758
1.44
4.18
4.8
3.1
—
—
—
0
0
11
27
4.13
4.18
1.4
1.3
—
—
—
0
0
21
80
2.69
4.10
1.6
1.4
106.9
100.4
u/ml
—
8
16
21
80
2.69
4.10
3.6
4.0
0.6
1.7
%
1.01
16
65
303
2529
1.41
4.09
8.8
6.4
12.2
11.3
umol/l
0.24
292
2404
237
1896
1.42
4.07
4.1
3.7
35.8
44.8
ng/l
0.49
168
1354
21
81
2.65
4.01
1.5
1.2
314.9
281.9
u/ml
0.16
14
45
112
774
1.55
4.01
1.4
1.3
12.9
13.0
u/ml
0.01
51
298
23
94
2.51
3.93
3.0
2.1
140.2
128.5
g/l
0.82
17
71
17
59
2.94
3.93
4.7
4.1
—
—
—
0
0
141
1031
1.49
3.87
1.7
1.7
447.5
6778084.0
pmol/l
0.50
126
841
7
8
8.84
3.78
2.0
2.3
—
—
—
0
0
24
103
2.39
3.71
4.5
4.0
14.6
31.2
mg/l
3.02
19
64
51
298
1.78
3.49
1.6
1.4
—
—
—
0
0
57
348
1.71
3.36
2.1
1.7
—
—
—
0
0
19
79
2.45
3.17
3.7
3.1
4.9
4.6
e9/l
0.22
19
79
273
2313
1.34
3.04
5.1
3.7
0.0
0.0
estimate
0.00
58
433
412
3717
1.37
2.99
10.9
7.6
76.5
78.4
u/l
0.52
399
3480
19
82
2.36
2.94
4.0
3.4
61.5
58.1
%
0.56
19
82
325
2835
1.33
2.92
7.2
4.7
6.8
6.7
mmol/l
0.18
313
2660
230
1914
1.33
2.84
3.0
2.3
76.0
77.0
nmol/l
0.21
218
1703
15
59
2.58
2.80
1.2
1.1
—
—
—
0
0
87
621
1.47
2.67
10.1
5.7
1.0
1.0
mmol/l
0.19
82
575
271
2328
1.31
2.61
6.4
5.0
0.0
0.0
estimate
0.00
58
429
28
149
1.92
2.60
1.3
1.7
0.1
0.1
iu/ml
—
8
32
180
1463
1.33
2.57
3.0
2.1
213.3
212.1
u/l
0.01
166
1381
61
408
1.55
2.54
2.8
3.3
67.6
66.6
g/l
0.35
56
373
273
2354
1.30
2.54
5.1
3.7
0.0
0.0
estimate
0.50
57
415
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
28
151
1.90
2.51
4.0
3.2
0.3
0.3
u/ml
1.12
20
83
86
620
1.45
2.51
8.8
6.8
104.0
104.1
mmol/l
0.08
81
603
22
109
2.06
2.49
2.7
3.2
36.2
35.5
umol/l
0.05
16
93
8
21
3.85
2.47
1.6
2.4
—
—
—
0
0
8
21
3.85
2.47
1.6
2.4
—
—
—
0
0
8
21
3.85
2.47
1.6
2.4
—
—
—
0
0
194
1616
1.30
2.29
4.7
3.4
2.3
2.4
mmol/l
0.17
180
1417
157
1273
1.32
2.25
4.6
2.7
353.7
7698.4
umol/l
5.64
141
1095
22
114
1.97
2.23
1.2
1.2
—
—
—
0
0
135
1072
1.34
2.23
2.0
1.7
1.1
1.3
mg/l
0.32
110
839
5
9
5.59
2.21
1.0
2.9
—
—
—
0
0
187
1560
1.29
2.16
4.7
3.2
28.9
31.6
u/l
1.19
182
1488
19
95
2.03
2.13
3.7
2.3
18.0
16.0
%
0.74
12
43
26
146
1.82
2.10
1.4
1.2
—
—
—
0
0
5
10
5.03
2.07
1.0
1.0
—
—
—
0
0
12
50
2.43
2.03
1.2
1.1
—
—
—
0
0
14
63
2.25
2.02
1.3
1.3
1.4
1.8
u/ml
—
5
17
14
64
2.22
1.96
1.1
1.1
—
—
—
0
0
32
196
1.67
1.94
2.3
2.0
—
—
—
0
0
8
27
2.99
1.94
1.6
2.1
—
—
—
0
0
8
27
2.99
1.94
1.6
2.1
—
—
—
0
0
8
27
2.99
1.94
1.6
2.1
—
—
—
0
0
8
27
2.99
1.94
1.6
2.1
—
—
—
0
0
7
22
3.21
1.88
1.6
2.1
100.3
94.5
%
—
7
22
345
3133
1.25
1.87
6.1
4.4
51.7
1388.9
e6/l
1.00
14
54
6
17
3.55
1.84
1.0
3.2
212.5
211.8
u/l
—
6
17
8
30
2.69
1.73
1.1
1.4
—
—
—
0
0
147
1224
1.27
1.69
2.5
2.1
3.2
3.1
mg/l
0.20
136
1049
159
1337
1.26
1.68
4.3
3.0
0.2
0.5
e6/l
2.51
134
998
24
388
0.60
1.66
1.7
1.7
—
—
—
0
0
11
49
2.27
1.64
1.5
1.9
—
—
—
0
0
11
49
2.27
1.64
1.5
1.9
—
—
—
0
0
11
49
2.27
1.64
1.5
1.9
—
—
—
0
0
84
665
1.31
1.43
2.8
2.4
20.6
22.4
%
0.63
68
579
71
550
1.33
1.41
4.4
4.3
265.0
247.5
u/l
0.52
64
524
9
40
2.27
1.40
1.4
1.3
—
—
—
0
0
14
74
1.91
1.40
1.1
1.1
—
—
—
0
0
9
41
2.21
1.37
1.1
1.1
—
68.0
—
0
5
13
68
1.93
1.34
1.3
1.3
8.2
4.1
u/ml
—
6
29
5
18
2.79
1.28
2.2
1.2
9.5
8.9
ug/l
—
5
18
24
154
1.58
1.28
2.5
4.1
25.2
32.7
mg/l
0.90
16
123
24
154
1.58
1.28
2.5
4.1
34.0
95.4
mg/l
0.83
16
123
45
599
0.73
1.23
4.7
4.7
31.0
32.0
%
0.25
35
395
20
124
1.63
1.22
1.2
1.7
—
—
—
0
0
78
626
1.28
1.22
29.2
24.3
1.6
1.2
inr
0.82
11
81
6
26
2.32
1.19
16.5
16.1
1075.8
1715.9
nmol/l
—
6
26
16
95
1.70
1.15
2.2
1.6
—
—
—
0
0
7
30
2.35
1.12
7.0
3.4
—
—
—
0
0
32
226
1.44
1.12
1.4
2.2
1.7
1.5
g/l
0.58
24
201
244
2216
1.17
1.12
5.6
4.1
—
—
—
0
0
232
2101
1.17
1.10
7.6
4.7
34.6
35.6
g/l
1.76
225
1958
5
21
2.39
1.09
1.2
1.1
—
—
—
0
0
428
4472
0.84
1.09
19.8
13.5
77.6
79.6
ml/min/173m2
0.93
355
3704
21
138
1.54
1.04
1.3
1.3
—
—
—
0
0
377
3560
1.17
1.01
4.1
3.9
14.9
14.9
pmol/l
0.12
357
3211
5
23
2.18
0.98
2.6
2.4
526.4
781.1
u/ml
—
5
23
13
78
1.68
0.92
1.2
1.4
—
—
—
0
0
6
28
2.15
0.91
1.0
1.2
—
—
—
0
0
108
931
1.20
0.91
1.9
1.7
1161.8
1186.7
nmol/l
0.11
95
709
18
119
1.53
0.89
1.3
1.6
11465.0
15839.1
e6/l
0.28
13
92
8
42
1.92
0.89
4.9
2.0
14.2
13.2
%
—
8
42
25
178
1.42
0.87
2.2
1.8
—
—
—
0
0
8
46
1.75
0.82
1.4
1.3
8717.1
209953.8
e6/l
—
8
34
168
1517
1.15
0.80
3.7
3.1
7.7
7.6
mmol/l
0.17
151
1261
503
4895
1.20
0.80
24.9
17.0
139.7
139.7
mmol/l
0.03
493
4774
489
4748
1.19
0.79
23.7
14.5
20.4
23.9
mg/l
2.10
435
3799
6
34
1.77
0.76
1.2
1.1
—
—
—
0
0
0
28
0.00
0.76
0.0
1.2
—
—
—
0
0
55
454
1.23
0.73
4.7
3.6
1.2
2.0
mmol/l
0.72
50
364
9
57
1.59
0.71
1.2
1.2
0.6
0.5
nmol/l
—
9
50
503
4910
1.18
0.68
25.0
17.2
4.0
4.0
mmol/l
2.08
493
4783
7
43
1.64
0.67
1.4
1.0
—
—
—
0
0
20
145
1.39
0.66
1.7
1.6
—
—
—
0
0
119
1324
0.87
0.65
1.8
1.7
1.4
1.4
mmol/l
0.31
106
1103
55
461
1.21
0.65
4.7
3.5
5.7
5.8
kpa
0.21
55
448
8
127
0.62
0.64
1.5
1.2
—
—
—
0
0
93
820
1.16
0.62
3.4
2.7
0.8
1.2
e6/l
1.45
64
464
8
49
1.64
0.62
2.0
2.6
5.3
6.6
nmol/l
—
8
49
5
30
1.67
0.61
1.2
1.8
—
—
—
0
0
430
4427
0.89
0.58
6.3
5.9
42.1
40.2
mmol/mol
1.15
408
4115
267
2814
0.91
0.56
2.9
2.8
—
—
—
0
0
9
61
1.48
0.54
1.2
1.7
—
—
—
0
0
37
305
1.23
0.53
2.0
1.7
—
—
—
0
0
145
1335
1.11
0.52
4.9
4.4
21.4
21.2
%
0.06
81
625
16
212
0.75
0.49
1.1
1.0
—
—
—
0
0
15
111
1.36
0.47
1.5
1.2
384.1
457.5
mg/l
0.87
15
103
105
955
1.12
0.47
4.5
3.8
1085.4
268.2
ng/l
0.69
86
745
15
113
1.34
0.43
1.4
1.5
—
—
—
0
0
186
1970
0.92
0.42
2.0
2.0
91.2
95.3
pmol/l
0.65
105
1027
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
28.6
—
0
10
0
15
0.00
0.41
0.0
2.2
—
—
—
0
0
100
915
1.11
0.41
3.1
3.0
2.5
2.5
mmol/l
0.93
91
804
0
16
0.00
0.41
0.0
1.2
—
308.7
—
0
10
21
169
1.25
0.39
3.4
2.9
3.3
3.1
g/l
0.29
13
137
470
4613
1.10
0.37
4.9
4.6
5.9
6.0
mmol/l
1.80
443
4200
15
116
1.30
0.37
1.2
1.5
—
—
—
0
0
85
777
1.11
0.36
3.6
2.8
2.0
2.0
e6/l
0.02
55
422
22
181
1.22
0.35
3.3
2.8
3.5
3.7
g/l
0.26
13
135
22
181
1.22
0.35
3.3
2.8
—
—
—
0
0
22
181
1.22
0.35
3.3
2.8
8.1
7.4
g/l
0.67
13
142
210
2004
1.07
0.34
3.3
2.7
152.2
135.8
ug/l
0.45
202
1830
66
599
1.11
0.33
8.3
7.4
—
—
—
0
0
55
494
1.13
0.32
3.7
3.3
—
—
—
0
0
160
1517
1.08
0.31
4.4
4.0
11.7
9.8
mg/mmol
0.21
118
960
320
3109
1.07
0.30
3.7
3.1
48.5
49.7
u/l
0.12
309
2909
10
130
0.77
0.29
1.2
1.5
—
—
—
0
0
17
139
1.23
0.29
1.6
1.6
40.5
42.0
nmol/l
0.11
17
131
32
364
0.87
0.28
1.8
1.7
—
—
—
0
0
20
168
1.20
0.27
2.3
1.6
—
—
—
0
0
8
67
1.20
0.26
8.6
5.0
374.3
363.0
umol/l
—
8
58
79
734
1.09
0.26
1.5
1.4
—
—
—
0
0
16
133
1.21
0.24
2.1
1.6
—
—
—
0
0
172
1652
1.06
0.23
5.4
5.0
2.9
2.7
ug/l
0.13
159
1483
16
134
1.20
0.23
9.1
3.0
1.7
1.6
mg/l
0.13
16
123
43
391
1.11
0.22
3.6
2.7
4.2
4.4
kpa
0.21
43
376
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
5
43
1.16
0.21
1.6
1.1
1.0
1.7
nmol/l
—
5
37
6
50
1.20
0.19
1.3
1.1
—
—
—
0
0
6
51
1.18
0.19
1.3
1.1
—
—
—
0
0
14
164
0.85
0.18
1.4
1.7
—
—
—
0
0
7
58
1.21
0.18
2.0
2.8
—
—
—
0
0
19
166
1.15
0.18
3.1
2.9
9.8
10.4
g/l
0.17
14
147
11
91
1.21
0.17
1.5
3.8
617.2
493.4
u/ml
0.08
11
86
31
282
1.10
0.17
1.1
1.2
49.8
141.1
iu/ml
2.25
15
114
5
68
0.73
0.17
2.8
2.2
4.0
63.9
u/ml
—
5
63
12
139
0.86
0.14
1.0
1.3
—
—
—
0
0
57
539
1.06
0.14
2.1
1.8
1.6
1.5
%
0.20
51
476
21
232
0.90
0.13
3.9
3.0
37.7
60.1
u/ml
0.51
21
222
5
44
1.14
0.10
1.0
1.0
—
—
—
0
0
5
45
1.11
0.10
1.0
1.1
—
—
—
0
0
5
46
1.09
0.09
2.0
3.0
24.0
51.2
u/ml
—
5
46
5
46
1.09
0.09
2.2
2.8
—
—
—
0
0
26
243
1.07
0.09
2.5
2.3
0.6
0.7
%
0.33
26
235
23
247
0.93
0.09
1.5
1.3
—
—
—
0
0
18
165
1.09
0.09
1.3
1.1
—
—
—
0
0
5
63
0.79
0.08
1.0
1.0
—
—
—
0
0
38
399
0.95
0.08
1.9
1.8
—
—
—
0
0
18
166
1.09
0.08
1.3
1.1
—
—
—
0
0
8
74
1.08
0.07
1.3
1.6
—
—
—
0
0
434
4313
1.02
0.07
4.9
4.7
2.0
2.2
mu/l
0.46
410
3915
524
5260
0.96
0.07
31.9
21.6
136.0
135.5
g/l
0.28
519
5179
9
85
1.06
0.07
1.7
1.6
—
—
—
0
0
59
571
1.04
0.07
2.4
2.4
8.1
8.6
umol/l
0.08
50
500
97
992
0.97
0.06
1.3
1.2
0.7
1.7
u/ml
1.39
28
268
472
4699
1.02
0.06
4.6
4.5
4.6
4.6
mmol/l
0.03
452
4341
478
4799
0.98
0.05
5.1
5.0
2.8
2.7
mmol/l
0.23
454
4402
507
5056
1.02
0.04
14.4
10.6
26.4
26.2
u/l
0.08
496
4879
466
4674
0.98
0.03
4.6
4.5
1.4
1.5
mmol/l
1.54
444
4287
54
529
1.02
0.03
3.0
4.3
20.7
34.6
ug/l
0.31
49
447
394
3951
0.99
0.02
26.4
17.7
13.9
13.7
%
2.05
388
3872
95
959
0.99
0.01
3.1
3.0
0.8
0.8
ug/l
0.10
74
637
60
592
1.02
0.01
1.4
1.4
—
—
—
0
0
10
94
1.06
0.01
1.6
1.3
—
—
—
0
0
10
94
1.06
0.01
1.6
1.3
—
—
—
0
0
453
4523
1.01
0.00
4.2
4.0
1.3
1.3
mmol/l
0.89
430
4132
12
124
0.97
0.00
1.8
1.5
—
—
—
0
0
115
1149
1.00
0.00
3.3
2.4
—
—
—
0
0
7
71
0.99
0.00
1.3
1.4
—
—
—
0
0
7
69
1.01
0.00
1.3
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
71
0.99
0.00
1.3
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
7
69
1.01
0.00
1.3
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
8
84
0.95
0.00
3.7
1.2
216.1
41.2
u/l
—
8
73
7
71
0.99
0.00
1.3
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
0.00
1.3
1.6
—
—
—
0
0
7
69
1.01
0.00
1.3
1.6
—
—
—
0
0
121
1210
1.00
0.00
1.5
1.5
17.6
21.0
nmol/l
1.74
115
1024
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
5
58
0.86
0.00
1.4
1.5
22.4
16.7
ug/l
—
5
58
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
7
70
1.00
0.00
1.3
1.6
—
—
—
0
0
7
70
1.00
0.00
1.3
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
52.4
—
0
5
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint J10_HYPERSPNEUMONI and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_HYPERSPNEUMONI | 1.979 [1.7, 2.31] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.224 |
During the follow-up period (1.1.1998 — 31.12.2019), 288 out of 1173 females with J10_HYPERSPNEUMONI died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_HYPERSPNEUMONI | 1.516 [1.31, 1.76] | < 0.001 |
| Birth year | 0.985 [0.97, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 358 out of 1282 males with J10_HYPERSPNEUMONI died.
Mortality risk
Mortality risk for people of age
years, who have J10_HYPERSPNEUMONI.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.223% | 0.299% |
| 5 | 1.17% | 1.727% |
| 10 | 2.856% | 4.114% |
| 15 | 5.534% | 7.983% |
| 20 | 9.455% | 13.086% |
Relationships between endpoints
↥Index endpoint: J10_HYPERSPNEUMONI – Hypersensitivity pneumonitis due to organic dust
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data