extrinsic allergic alveolitis: An inflammatory interstitial lung disease caused by hypersensitivity reaction to inhalation or ingestion of antigens. The antigens are usually related to the patient's occupation. It can present as an acute illness with flu-like symptoms, subacute with repeated episodes of pneumonia, or chronic with dyspnea and productive cough. The majority of patients recover following the cessation of the exposure to the antigen that causes the disease. Chronic exposure may eventually progress to interstitial lung fibrosis.
Hypersensitivity pneumonitis due to organic dust
DOID EFO Endpoint Browser PheWeb
J10_HYPERSPNEUMONI
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
592 |
4. Check minimum number of eventsNone |
592 |
5. Include endpointsNone |
592 |
6. Filter based on genotype QC (FinnGen only) |
584 |
Control definitions (FinnGen only)
- Control exclude
- J10_EXTERLUNG
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- J60-J70
- Name in latin
- Pneumonitis/alveolitis hypersensitiva e pulvere organico
Similar endpoints
↥List of similar endpoints to
Hypersensitivity pneumonitis due to organic dust
based on the number of shared cases.
Similar with more cases:
- Lung diseases due to external agents
- Diagnoses used for exclusion with ILD
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5824 | 2873 | 2887 |
| Only index persons | 4602 | 2341 | 2261 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.09 | 0.09 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 52.93 | 53.15 | 52.37 |
| Only index persons | 49.96 | 50.96 | 48.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 584 | 302 | 282 |
| Unadjusted period prevalence (%) | 0.12 | 0.11 | 0.13 |
| Median age at first event (years) | 49.98 | 47.68 | 52.43 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 592
- Matched controls
- 5920
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J67.0
ICD-10 Finland
Farmer lung
+∞
221.1
198
*
J67.9
ICD-10 Finland
Hypersensitivity pneumonitis due to unspecified organic dust
+∞
197.2
178
*
4950A
ICD-9 Finland
Extrinsic allergic alveolitis, Farmers' lung
+∞
125.6
116
*
TGC00
NOMESCO Finland
Bronchial lavation
15.1
103.2
97
76
4959X
ICD-9 Finland
Extrinsic allergic alveolitis, Unspecified allergic alveolitis and pneumonitis
+∞
94.3
88
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
7.9
61.5
92
135
UGC12
NOMESCO Finland
Flexible bronchoscopy
5.8
57.9
122
254
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
12.8
57.6
58
50
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
12.8
57.6
58
50
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
10.1
55.3
66
73
H02AB06
ATC
prednisolone; systemic
3.8
51.6
400
2104
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
4.5
46.0
132
353
J67.8
ICD-10 Finland
Hypersensitivity pneumonitis due to other organic dusts
+∞
44.3
42
*
J45.1
ICD-10 Finland
Nonallergic asthma
4.7
36.3
92
221
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
5.3
34.2
75
159
J45.9
ICD-10 Finland
Asthma, unspecified
3.2
33.8
178
704
XG410
NOMESCO Finland
Flow-volume spirometry
6.3
32.4
57
98
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
7.3
30.1
46
68
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
3.0
29.6
176
740
J45.0
ICD-10 Finland
Predominantly allergic asthma
4.0
29.1
93
265
51610
ICD-8 Finland
Other pneumoconiosis and related diseases, Due to inhalation of other dust
+∞
28.4
27
*
R03BA01
ATC
beclometasone; inhalant
3.1
25.3
127
481
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
24.9
205
1005
R06.0
ICD-10 Finland
Dyspnoea
2.5
24.1
218
1116
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
8.9
22.1
28
33
R03AC02
ATC
salbutamol; inhalant
2.3
20.7
368
2473
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
33.9
20.3
26
8
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
7.0
19.3
30
45
J01FA06
ATC
roxithromycin; oral
2.2
18.5
277
1712
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.4
18.4
73
238
4958X
ICD-9 Finland
Extrinsic allergic alveolitis, Other specified allergic alveolitis and pneumonitis
+∞
17.8
17
*
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
13.8
17.1
29
22
GD1AD
NOMESCO Finland
Thorax CT examination
3.5
17.0
61
186
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
16.3
15.8
25
16
L04AX01
ATC
azathioprine; systemic
4.4
15.8
41
99
R03AK08
ATC
formoterol and beclometasone; inhalant
4.1
15.0
43
112
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.4
14.5
113
526
1240
FHL
Bronchoscopy
10.8
14.4
27
26
L04AA06
ATC
mycophenolic acid; systemic
6.7
13.7
22
34
J67.1
ICD-10 Finland
Bagassosis
+∞
13.6
13
*
J47
ICD-10 Finland
Bronchiectasis
5.4
13.1
26
50
J45.8
ICD-10 Finland
Mixed asthma
4.6
13.0
31
70
R50.9
ICD-10 Finland
Fever, unspecified
2.3
12.9
107
510
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.7
12.7
42
121
R03AC12
ATC
salmeterol; inhalant
3.5
12.7
46
141
R03BB04
ATC
tiotropium bromide; inhalant
2.5
12.7
84
361
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
17.8
12.6
19
11
J67.2
ICD-10 Finland
Bird fancier lung
+∞
12.5
12
*
A41.9
ICD-10 Finland
Sepsis, unspecified
4.0
12.5
36
94
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
12.9
11.7
20
16
R03BA02
ATC
budesonide; inhalant
2.1
11.5
125
664
J66.8
ICD-10 Finland
Airway disease due to other specific organic dusts
+∞
11.5
11
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.6
10.8
69
291
51620
ICD-8 Finland
Other pneumoconiosis and related diseases, Due to inhalation of fumes
+∞
10.4
10
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.9
10.4
50
182
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
10.2
290
2091
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
10.1
145
847
R03AC03
ATC
terbutaline; inhalant
2.1
9.4
92
467
J01MA12
ATC
levofloxacin; systemic
2.0
9.2
122
692
4931A
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA SINE EXACERBATIONE]
10.3
9.1
17
17
J84.0
ICD-10 Finland
Alveolar and parietoalveolar conditions
37.3
9.0
11
*
J01MA14
ATC
moxifloxacin; systemic
2.4
9.0
67
303
4779A
ICD-9 Finland
Allergic rhinitis, Cause unspecified
8.8
8.8
18
21
R06.2
ICD-10 Finland
Wheezing
3.2
8.7
34
110
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
11.8
8.6
15
13
J67.7
ICD-10 Finland
Air-conditioner and humidifier lung
+∞
8.3
8
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
8.0
205
1412
7860A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Dyspnoea and respiratory abnormalities[DYSPNOEA]
8.6
7.9
16
19
R03DA04
ATC
theophylline; systemic, rectal
2.7
7.8
43
169
XG474
NOMESCO Finland
Exhalation nntrogen oxide
3.4
7.6
27
82
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.9
7.5
105
604
R03AK07
ATC
formoterol and budesonide; inhalant
1.8
7.4
119
716
4610A
ICD-9 Finland
Acute sinusitis, Maxillary
5.9
7.3
19
33
R05
ICD-10 Finland
Cough
1.8
7.2
123
753
4900A
ICD-9 Finland
Bronchitis, not specified as acute or chronic[BRONCHITIS NUD]
20.3
7.2
10
5
Z94.2
ICD-10 Finland
Lung transplant status
20.3
7.2
10
5
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
8.9
7.1
14
16
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
4.1
6.9
19
48
R03BA08
ATC
ciclesonide; inhalant
2.2
6.9
57
270
GDA10
NOMESCO Finland
Biopsy of lung
16.9
6.8
10
6
R04.2
ICD-10 Finland
Haemoptysis
3.1
6.7
27
89
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
6.5
113
695
J96.1
ICD-10 Finland
Chronic respiratory failure
3.8
6.4
19
51
3820A
ICD-9 Finland
Suppurative and unspecified otitis media, Acute suppurative otitis media
8.3
6.4
13
16
J67
ICD-10 Finland
Hypersensitivity pneumonitis due to organic dust
+∞
6.3
6
*
R99
ICPC
Respiratory disease other
3.8
6.1
18
48
J01AA02
ATC
doxycycline; systemic
1.6
6.1
446
3860
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
6.8
6.1
14
21
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.2
6.1
54
264
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
92
180
5.87
46.20
3.2
2.8
—
—
—
0
0
51
52
10.64
45.11
2.3
1.8
—
—
—
0
0
101
278
4.17
33.29
1.8
1.2
139.07
163.45
u/ml
0.18
90
247
36
39
9.76
30.32
1.4
1.2
0.12
1.26
u/ml
0.60
20
21
50
91
5.91
26.77
2.4
1.6
—
—
—
0
0
41
72
6.04
22.72
2.5
1.6
—
—
—
0
0
53
119
4.79
22.42
2.4
1.8
—
—
—
0
0
52
124
4.50
20.41
2.4
1.8
—
—
—
0
0
131
563
2.70
20.33
6.9
7.9
1.06
1.25
mmol/l
0.22
106
453
131
567
2.68
20.03
6.8
7.8
5.03
5.11
kpa
0.45
125
544
131
568
2.68
19.95
6.8
7.7
10.27
12.16
kpa
4.67
126
545
57
162
3.79
17.67
1.8
1.6
700.00
163.33
titre
—
6
6
41
93
4.66
17.09
1.3
1.2
—
—
—
0
0
47
120
4.17
16.87
2.5
1.5
—
—
—
0
0
39
88
4.67
16.36
2.4
1.9
—
—
—
0
0
39
88
4.67
16.36
2.4
1.9
—
—
—
0
0
38
88
4.55
15.44
2.6
1.9
—
—
—
0
0
82
326
2.76
14.55
6.7
7.0
24.89
24.56
mmol/l
0.34
77
311
29
56
5.39
14.52
3.0
1.7
—
—
—
0
0
30
61
5.13
14.19
2.6
1.7
—
—
—
0
0
30
61
5.13
14.19
2.6
1.7
—
—
—
0
0
32
71
4.71
13.69
1.9
1.6
—
—
—
0
0
34
80
4.45
13.54
1.8
1.6
—
—
—
0
0
24
22
11.32
13.12
2.4
1.5
—
—
—
0
0
89
389
2.52
13.01
4.1
2.8
11.41
10.45
g/l
0.55
83
358
30
73
4.28
11.46
2.8
1.6
—
—
—
0
0
225
1484
1.83
10.90
3.6
3.2
1225.38
1410.27
ng/l
0.30
203
1271
363
2782
1.79
10.41
13.1
9.2
4.44
4.15
e9/l
1.83
341
2445
44
149
3.11
10.38
1.8
1.7
—
—
—
0
0
28
72
4.03
9.96
1.2
1.2
—
—
—
0
0
306
2258
1.74
9.78
9.7
5.8
60.37
57.44
%
4.71
299
2127
140
825
1.91
9.47
1.4
1.3
31.36
38.65
iu/ml
0.34
43
280
20
25
8.24
9.41
1.9
2.0
—
—
—
0
0
65
285
2.44
9.38
7.4
3.8
2.13
1.70
mmol/l
0.37
51
224
308
2299
1.71
9.25
10.2
6.0
24.91
27.39
%
4.27
301
2162
36
118
3.18
8.97
1.4
1.2
4.14
7.33
u/ml
—
5
21
32
99
3.36
8.74
20.3
7.6
268.29
199.94
iu/ml
0.22
14
17
23
57
4.16
8.59
1.6
2.2
—
—
—
0
0
21
49
4.41
8.46
1.2
1.1
—
—
—
0
0
30
92
3.38
8.32
1.3
1.2
6.40
1.06
u/ml
—
5
7
188
1279
1.69
7.63
5.3
3.9
0.00
0.01
estimate
0.69
56
425
21
54
4.00
7.49
1.7
2.2
—
—
—
0
0
13
12
11.05
7.32
1.3
1.2
—
—
—
0
0
131
822
1.76
7.05
2.7
1.9
—
—
—
0
0
36
136
2.75
7.03
1.7
1.5
—
—
—
0
0
20
53
3.87
6.86
1.2
1.5
—
—
—
0
0
158
1059
1.67
6.66
5.6
4.0
1.02
1.02
kg/l
0.19
19
144
153
1023
1.67
6.49
3.5
2.5
5.46
5.63
e6/l
0.05
142
924
422
3588
1.61
6.35
7.1
4.1
13.73
12.54
mm/h
0.84
401
3290
16
29
5.64
6.03
2.1
2.0
0.16
0.16
e9/l
0.01
16
24
13
18
7.36
5.95
4.8
5.8
—
—
—
0
0
16
31
5.27
5.74
2.2
1.6
—
—
—
0
0
16
31
5.27
5.74
1.4
1.2
—
—
—
0
0
304
2440
1.51
5.62
9.0
6.8
1.21
1.21
mmol/l
0.24
266
2088
239
1828
1.52
5.55
5.1
3.9
—
—
—
0
0
10
10
10.15
5.55
4.4
1.7
—
—
—
0
0
119
784
1.65
5.25
1.4
1.3
12.64
12.82
u/ml
0.01
52
302
204
1530
1.51
5.11
3.0
2.4
62.05
60.16
u/l
0.13
194
1430
24
87
2.83
5.10
1.5
1.2
—
—
—
0
0
68
385
1.87
5.08
2.7
2.7
66.73
64.14
ml/min/173m2
0.22
33
162
280
2242
1.47
5.06
8.1
5.9
1.21
1.21
mmol/l
0.79
266
2038
12
21
5.81
4.77
3.7
1.8
31.98
56.20
ug/l
1.64
12
21
91
579
1.68
4.57
2.8
1.8
—
—
—
0
0
51
272
1.96
4.57
3.5
2.7
0.20
0.21
e6/l
0.04
51
264
310
2566
1.44
4.52
8.7
6.4
12.23
11.32
umol/l
0.25
299
2440
243
1924
1.45
4.50
4.1
3.7
35.53
44.34
ng/l
0.48
171
1378
27
112
2.48
4.45
1.2
1.4
—
—
—
0
0
22
83
2.71
4.37
1.5
1.2
312.07
296.09
u/ml
0.08
15
46
227
1783
1.44
4.36
4.7
3.1
—
—
—
0
0
90
579
1.65
4.33
2.7
1.8
—
—
—
0
0
12
25
4.88
4.20
2.7
1.6
—
—
—
0
0
24
97
2.54
4.18
3.0
2.1
140.94
127.37
g/l
1.07
18
73
194
1489
1.45
4.18
4.5
3.1
135.89
101.94
e6/l
0.13
167
1139
18
63
2.92
4.09
7.4
5.4
11.82
11.31
mg/l
0.20
13
58
12
26
4.69
4.07
2.7
1.6
—
—
—
0
0
25
105
2.44
4.03
4.4
4.1
14.88
30.97
mg/l
2.98
20
65
21
81
2.65
4.01
1.6
1.4
106.88
100.44
u/ml
—
8
16
14
37
3.85
3.91
2.4
1.6
—
—
—
0
0
142
1045
1.47
3.75
1.7
1.7
450.32
11345466.18
pmol/l
0.79
127
855
17
61
2.84
3.71
4.7
4.1
—
—
—
0
0
280
2329
1.38
3.71
20.1
15.2
1.36
1.26
inr
0.82
92
672
7
9
7.85
3.56
2.0
2.1
—
—
—
0
0
52
306
1.77
3.47
1.6
1.4
—
—
—
0
0
214
1719
1.38
3.44
5.1
3.7
188.99
103.25
e6/l
0.52
174
1220
421
3771
1.40
3.41
10.9
7.6
76.80
78.25
u/l
0.37
408
3534
237
1942
1.37
3.35
3.0
2.3
76.25
76.99
nmol/l
0.15
223
1725
16
59
2.76
3.34
1.2
1.1
2.17
0.82
u/ml
—
5
28
333
2881
1.36
3.29
7.3
4.7
6.81
6.72
mmol/l
0.23
321
2709
11
29
3.84
3.20
1.4
1.3
—
—
—
0
0
57
354
1.68
3.16
2.1
1.7
—
—
—
0
0
16
61
2.67
3.15
1.2
1.1
—
—
—
0
0
19
81
2.39
3.01
3.7
3.1
4.91
4.55
e9/l
0.27
19
81
64
415
1.61
3.01
2.7
3.3
67.42
66.50
g/l
0.33
58
380
9
21
4.33
3.00
1.6
2.4
—
—
—
0
0
9
21
4.33
3.00
1.6
2.4
—
—
—
0
0
9
21
4.33
3.00
1.6
2.4
—
—
—
0
0
185
1483
1.36
2.93
3.1
2.1
209.78
210.54
u/l
0.00
171
1399
276
2354
1.32
2.86
5.2
3.7
0.00
0.00
estimate
0.50
66
473
19
84
2.30
2.80
4.0
3.5
61.53
57.85
%
0.62
19
84
89
633
1.48
2.77
10.1
5.7
1.04
1.02
mmol/l
0.26
84
586
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
29
155
1.92
2.66
4.2
3.3
0.26
0.34
u/ml
1.19
20
85
28
150
1.91
2.56
1.3
1.6
0.11
0.10
iu/ml
—
8
32
274
2362
1.30
2.53
6.4
5.0
0.00
0.00
estimate
-0.00
60
435
22
109
2.06
2.49
2.7
3.2
34.86
35.56
umol/l
0.04
17
97
276
2389
1.29
2.45
5.1
3.7
0.00
0.01
estimate
0.50
59
421
23
117
2.00
2.43
1.2
1.1
—
—
—
0
0
34
198
1.76
2.41
2.2
2.0
—
—
—
0
0
20
97
2.10
2.40
3.6
2.3
18.21
15.79
%
1.07
13
45
8
22
3.67
2.37
1.5
2.1
96.25
94.55
%
—
8
22
9
28
3.25
2.31
1.6
2.1
—
—
—
0
0
9
28
3.25
2.31
1.6
2.1
—
—
—
0
0
197
1642
1.30
2.30
4.7
3.4
2.35
2.35
mmol/l
0.18
183
1446
138
1094
1.34
2.30
2.0
1.7
1.14
1.26
mg/l
0.26
111
856
13
53
2.49
2.29
1.2
1.1
—
—
—
0
0
5
9
5.59
2.21
1.0
2.9
—
—
—
0
0
158
1290
1.31
2.13
4.6
2.7
355.28
7790.54
umol/l
5.86
144
1120
5
10
5.03
2.07
1.0
1.0
—
—
—
0
0
26
147
1.80
2.06
1.4
1.2
—
—
—
0
0
189
1587
1.28
2.05
4.8
3.3
29.11
31.51
u/l
1.01
184
1514
12
50
2.43
2.03
1.4
1.9
—
—
—
0
0
12
50
2.43
2.03
1.4
1.9
—
—
—
0
0
12
50
2.43
2.03
1.4
1.9
—
—
—
0
0
351
3184
1.25
1.93
6.0
4.4
51.71
1388.85
e6/l
1.00
14
54
89
678
1.37
1.92
2.8
2.4
20.66
22.38
%
0.63
72
590
14
65
2.18
1.89
1.3
1.3
1.40
1.78
u/ml
—
5
18
27
159
1.73
1.88
2.4
4.1
37.89
94.04
mg/l
0.76
19
127
6
17
3.55
1.84
1.0
3.2
212.50
211.82
u/l
—
6
17
14
66
2.15
1.83
1.1
1.1
—
—
—
0
0
24
396
0.59
1.79
1.7
1.7
—
—
—
0
0
150
1245
1.27
1.77
2.5
2.1
3.19
3.11
mg/l
0.19
138
1069
15
74
2.05
1.76
1.1
1.1
—
—
—
0
0
8
30
2.69
1.73
1.1
1.4
—
—
—
0
0
74
558
1.37
1.71
4.3
4.2
261.45
246.97
u/l
0.42
67
531
161
1356
1.26
1.67
4.3
3.0
0.24
0.47
e6/l
2.63
137
1016
10
41
2.46
1.65
1.1
1.1
—
68.00
—
0
5
60
440
1.40
1.64
8.7
7.2
1.28
1.39
mmol/l
0.57
60
428
26
159
1.66
1.61
2.5
4.1
39.15
32.50
mg/l
0.20
18
127
34
228
1.52
1.47
1.5
2.2
1.73
1.47
g/l
0.56
26
203
21
125
1.71
1.45
1.2
1.8
—
—
—
0
0
17
97
1.77
1.36
2.1
1.6
—
—
—
0
0
9
43
2.11
1.30
1.4
1.3
—
—
—
0
0
5
18
2.79
1.28
2.2
1.2
9.47
8.88
ug/l
—
5
18
5
18
2.79
1.28
1.0
1.1
1757.40
1491.06
miu/ml
—
5
18
13
70
1.88
1.24
1.3
1.2
8.17
4.13
u/ml
—
6
30
236
2125
1.18
1.21
7.6
4.7
34.57
35.59
g/l
1.85
227
1985
436
4565
0.83
1.19
19.8
13.5
77.54
79.78
ml/min/173m2
1.16
361
3784
22
142
1.57
1.16
1.3
1.3
—
—
—
0
0
7
30
2.35
1.12
7.0
3.4
—
—
—
0
0
5
21
2.39
1.09
1.2
1.1
—
—
—
0
0
166
1462
1.19
1.09
3.6
3.3
1581.46
239.27
mg/l
1.28
123
948
111
941
1.22
1.09
1.9
1.7
1176.73
1187.27
nmol/l
0.04
96
717
248
2260
1.17
1.08
3.5
2.6
—
—
—
0
0
19
122
1.58
1.03
1.3
1.6
11465.00
16075.53
e6/l
0.30
13
94
26
180
1.46
1.02
2.1
1.8
—
—
—
0
0
9
48
1.89
1.01
2.4
2.3
—
—
—
0
0
7
35
2.01
1.00
1.1
1.1
—
—
—
0
0
5
23
2.18
0.98
1.0
1.0
—
—
—
0
0
0
29
0.00
0.98
0.0
1.2
—
—
—
0
0
383
3624
1.16
0.97
4.1
3.9
14.88
14.86
pmol/l
0.05
361
3264
6
27
2.23
0.93
16.5
16.0
1075.83
1748.67
nmol/l
—
6
27
6
28
2.15
0.91
1.0
1.2
—
—
—
0
0
172
1542
1.16
0.90
3.7
3.1
7.79
7.57
mmol/l
0.25
154
1294
13
79
1.66
0.88
1.2
1.4
—
—
—
0
0
8
43
1.87
0.87
4.9
2.0
14.16
13.15
%
—
8
43
498
4831
1.19
0.84
23.7
14.5
20.25
23.92
mg/l
2.31
443
3855
21
147
1.44
0.81
1.7
1.6
—
—
—
0
0
8
47
1.71
0.81
1.4
1.4
8717.13
204001.97
e6/l
—
8
35
512
4984
1.20
0.80
25.0
17.0
139.66
139.66
mmol/l
0.01
501
4858
50
609
0.80
0.75
5.0
4.7
31.10
32.15
%
0.29
39
407
5
24
2.09
0.74
2.6
2.3
526.40
767.38
u/ml
—
5
24
56
465
1.23
0.71
4.7
3.5
1.03
2.00
mmol/l
0.97
51
385
9
58
1.56
0.70
1.2
1.2
0.63
0.56
nmol/l
—
9
51
38
303
1.27
0.68
1.9
1.7
—
—
—
0
0
512
4999
1.18
0.68
25.1
17.1
4.02
3.99
mmol/l
2.45
501
4867
8
130
0.61
0.64
1.5
1.3
—
—
—
0
0
56
472
1.21
0.63
4.6
3.5
5.75
5.83
kpa
0.25
56
459
8
49
1.64
0.62
2.0
2.6
5.25
6.56
nmol/l
—
8
49
94
832
1.15
0.60
3.4
2.7
0.77
1.16
e6/l
1.34
64
472
149
1366
1.12
0.57
4.9
4.4
21.49
21.28
%
0.07
83
637
24
186
1.30
0.55
3.2
2.7
—
—
—
0
0
123
1345
0.89
0.52
1.7
1.7
1.42
1.38
mmol/l
0.22
109
1121
9
65
1.39
0.50
1.2
1.6
—
—
—
0
0
330
3167
1.09
0.50
3.7
3.1
48.20
49.74
u/l
0.16
317
2964
7
45
1.56
0.49
1.4
1.0
—
—
—
0
0
69
609
1.15
0.48
8.1
7.4
—
—
—
0
0
106
963
1.12
0.48
4.6
3.8
1095.64
288.74
ng/l
0.69
87
751
216
2039
1.09
0.47
3.3
2.7
150.23
135.17
ug/l
0.41
207
1864
440
4507
0.91
0.45
6.3
5.9
42.01
40.18
mmol/mol
1.10
416
4187
5
31
1.62
0.43
1.2
1.8
—
—
—
0
0
15
113
1.34
0.43
1.5
1.2
384.13
456.11
mg/l
0.85
15
105
274
2858
0.92
0.42
2.9
2.8
—
—
—
0
0
32
380
0.83
0.42
1.8
1.7
—
—
—
0
0
5
33
1.52
0.41
3.0
1.4
70.00
78.21
umol/l
—
5
33
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
28.63
—
0
10
0
16
0.00
0.41
0.0
1.2
—
308.70
—
0
10
0
16
0.00
0.41
0.0
2.1
—
—
—
0
0
15
114
1.32
0.41
1.4
1.5
—
—
—
0
0
164
1540
1.09
0.40
4.3
3.8
11.71
9.68
mg/mmol
0.24
120
975
479
4698
1.10
0.40
5.0
4.6
5.87
5.99
mmol/l
1.84
449
4276
10
136
0.73
0.38
1.2
1.5
—
—
—
0
0
17
212
0.80
0.36
1.1
1.0
—
—
—
0
0
15
117
1.29
0.35
1.2
1.5
—
—
—
0
0
86
788
1.11
0.35
3.7
2.9
1.97
1.98
e6/l
0.01
56
430
100
924
1.10
0.35
3.2
3.0
2.47
2.45
mmol/l
0.92
91
813
6
45
1.34
0.34
1.0
1.0
—
—
—
0
0
80
739
1.10
0.29
1.5
1.4
—
—
—
0
0
7
57
1.23
0.29
2.0
2.8
—
—
—
0
0
55
501
1.11
0.27
3.7
3.3
—
—
—
0
0
192
1998
0.94
0.26
2.0
2.0
91.34
95.13
pmol/l
0.61
107
1045
176
1688
1.06
0.25
5.4
5.0
2.91
2.67
ug/l
0.13
162
1515
17
142
1.20
0.25
1.6
1.7
40.47
41.87
nmol/l
0.10
17
134
44
398
1.11
0.24
3.6
2.7
4.22
4.41
kpa
0.24
44
383
14
169
0.82
0.24
1.4
1.7
—
—
—
0
0
16
135
1.19
0.21
9.1
3.1
1.74
1.64
mg/l
0.13
16
124
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
32
287
1.12
0.21
1.1
1.2
47.58
144.98
iu/ml
2.65
16
116
5
43
1.16
0.21
1.6
1.1
0.97
1.65
nmol/l
—
5
37
16
136
1.18
0.20
2.1
1.6
—
—
—
0
0
6
50
1.20
0.19
1.3
1.1
—
—
—
0
0
6
52
1.16
0.19
1.3
1.1
—
—
—
0
0
38
415
0.91
0.19
1.9
1.8
—
—
—
0
0
20
176
1.14
0.17
2.3
1.6
—
—
—
0
0
8
69
1.16
0.16
8.6
5.0
374.25
360.77
umol/l
—
8
60
445
4400
1.05
0.16
4.9
4.7
1.96
2.22
mu/l
0.45
419
3993
11
93
1.19
0.14
1.5
3.9
617.20
482.43
u/ml
0.09
11
88
23
253
0.91
0.13
1.5
1.3
—
—
—
0
0
26
239
1.09
0.12
4.7
3.5
23.43
24.20
mmol/l
0.73
26
233
482
4785
1.04
0.11
4.7
4.5
4.63
4.64
mmol/l
0.06
460
4426
58
554
1.05
0.11
2.0
1.8
1.57
1.51
%
0.26
52
489
5
46
1.09
0.09
1.0
1.1
—
—
—
0
0
5
46
1.09
0.09
2.0
3.0
23.96
51.16
u/ml
—
5
46
60
576
1.05
0.09
2.4
2.4
8.40
8.60
umol/l
0.03
51
505
10
87
1.15
0.09
1.6
1.6
—
—
—
0
0
5
47
1.06
0.09
2.0
2.6
—
—
—
0
0
5
64
0.78
0.08
1.0
1.0
—
—
—
0
0
517
5148
1.03
0.07
14.4
10.5
26.39
26.21
u/l
0.08
506
4966
13
143
0.91
0.07
1.1
1.3
—
—
—
0
0
22
235
0.93
0.07
3.7
3.0
36.36
59.51
u/ml
0.54
22
225
18
167
1.08
0.07
1.3
1.1
—
—
—
0
0
119
1167
1.02
0.06
3.3
2.4
—
—
—
0
0
18
168
1.07
0.06
1.3
1.1
—
—
—
0
0
534
5355
0.97
0.05
31.9
21.5
135.85
135.49
g/l
0.20
529
5271
534
5354
0.97
0.04
31.6
21.4
4.56
4.49
e12/l
2.31
528
5211
462
4603
1.02
0.04
4.3
4.0
1.34
1.29
mmol/l
0.85
437
4206
534
5350
0.98
0.02
32.0
21.5
39.89
40.23
%
0.43
494
4982
99
982
1.01
0.01
3.1
3.0
0.83
0.78
ug/l
0.12
76
651
488
4886
0.99
0.00
5.1
5.0
2.75
2.73
mmol/l
0.14
462
4488
10
95
1.05
0.00
1.6
1.3
—
—
—
0
0
10
95
1.05
0.00
1.6
1.3
—
—
—
0
0
12
125
0.96
0.00
1.7
1.5
—
—
—
0
0
61
605
1.01
0.00
1.4
1.4
—
—
—
0
0
100
1004
1.00
0.00
1.4
1.2
0.73
1.75
u/ml
1.36
30
271
476
4758
1.00
0.00
4.7
4.5
1.42
1.46
mmol/l
1.48
452
4369
123
1232
1.00
0.00
1.5
1.5
17.60
20.94
nmol/l
1.76
117
1039
54
539
1.00
0.00
3.0
4.3
20.75
34.31
ug/l
0.30
49
455
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
8
81
0.99
0.00
1.3
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
7
76
0.92
-0.00
1.3
1.4
—
—
—
0
0
7
70
1.00
-0.00
1.3
1.6
—
—
—
0
0
7
77
0.91
-0.00
1.3
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
7
70
1.00
-0.00
1.3
1.6
—
—
—
0
0
7
71
0.99
-0.00
1.3
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
71
0.99
-0.00
1.3
1.6
—
—
—
0
0
7
71
0.99
-0.00
1.3
1.6
—
—
—
0
0
7
76
0.92
-0.00
1.3
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
52.40
—
0
5
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
7
70
1.00
-0.00
1.3
1.6
—
—
—
0
0
5
59
0.85
-0.00
1.4
1.5
22.40
16.60
ug/l
—
5
59
8
84
0.95
-0.00
3.8
1.2
216.11
41.23
u/l
—
8
73
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
7
77
0.91
-0.00
1.3
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint J10_HYPERSPNEUMONI and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_HYPERSPNEUMONI | 1.979 [1.7, 2.31] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.224 |
During the follow-up period (1.1.1998 — 31.12.2019), 288 out of 1173 females with J10_HYPERSPNEUMONI died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_HYPERSPNEUMONI | 1.516 [1.31, 1.76] | < 0.001 |
| Birth year | 0.985 [0.97, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 358 out of 1282 males with J10_HYPERSPNEUMONI died.
Mortality risk
Mortality risk for people of age
years, who have J10_HYPERSPNEUMONI.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.223% | 0.299% |
| 5 | 1.17% | 1.727% |
| 10 | 2.856% | 4.114% |
| 15 | 5.534% | 7.983% |
| 20 | 9.455% | 13.086% |
Relationships between endpoints
↥Index endpoint: J10_HYPERSPNEUMONI – Hypersensitivity pneumonitis due to organic dust
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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