No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
1648 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
361 |
4. Check minimum number of eventsNone |
361 |
5. Include endpointsNone |
361 |
6. Filter based on genotype QC (FinnGen only) |
361 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Open bite that required surgery (Lefort1 or BSSRO)
based on the number of shared cases.
Similar with more cases:
- LeFortI or BSSRO operation
- Open bite
- Anomalies of dental arch relationship, including avohilmo
- Dentofacial anomalies [including malocclusion]
- Diseases of oral cavity, salivary glands and jaws
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2132 | 1470 | 646 |
| Only index persons | 2100 | 1460 | 640 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.02 |
| Only index persons | 0.04 | 0.05 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 27.35 | 27.64 | 26.66 |
| Only index persons | 27.38 | 27.65 | 26.75 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 361 | 282 | 79 |
| Unadjusted period prevalence (%) | 0.08 | 0.10 | 0.03 |
| Median age at first event (years) | 29.96 | 29.30 | 32.29 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 312
- Matched controls
- 3119
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K07.24
ICD-10 Finland
Open bite
+∞
323.0
312
21
SJD00
NOMESCO Finland
Removal or reattacment of arrow in fixed orthodontisk device
427.2
281.2
249
28
EDC10
NOMESCO Finland
Sagittal osteotomy of ramus of mandible
1001.6
269.1
227
8
SJD10
NOMESCO Finland
Attachment of arrow to fixed orthodontisk device
321.1
252.0
230
27
SBB10
NOMESCO Finland
Teeth copy
143.5
247.5
266
120
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
190.8
232.9
226
42
SJC10
NOMESCO Finland
Orthodontic bandage in one tooth
363.8
224.7
204
16
EEC05
NOMESCO Finland
Le Fort I osteotomy
4609.6
221.6
187
*
SJD20
NOMESCO Finland
Attachment of modifiable arrow of fixed orthodontisk device
291.0
220.4
204
20
SJC50
NOMESCO Finland
Removal of orthodontisk device with at least 7 brackets
277.1
219.4
204
21
K07.13
ICD-10 Finland
Retrognaty, mandibular
244.6
206.7
195
21
SJB00
NOMESCO Finland
Fitting of loose orthodontic device with user information
212.5
196.1
188
22
SJD30
NOMESCO Finland
Demanding attachment of arrow to fixed orthodontisk device
274.5
170.4
161
12
EB1MA
NOMESCO Finland
Cephalometry with X-ray
132.7
168.2
171
28
SJX10
NOMESCO Finland
Short check-up visit for orthodontisk therapy
68.3
160.5
184
64
SJD40
NOMESCO Finland
Fixation of ready made palatinal or lingual arrow
175.9
160.3
158
18
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
167.7
140.6
140
15
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
45.1
122.5
153
65
SAA04
NOMESCO Finland
Special inverstigation of mouth
36.9
115.9
153
79
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
77.1
111.1
123
26
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
119.9
94.8
99
12
SJC00
NOMESCO Finland
Bracket with fixed attachment
996.2
81.3
76
*
SJX11
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment, restricted
71.5
78.3
88
17
SXC05
NOMESCO Finland
Other oral or dental procedure
19.9
77.5
124
100
SJX20
NOMESCO Finland
Check-up visit for orthodontisk therapy
39.0
74.0
94
34
SJB60
NOMESCO Finland
External device grinding and adaptation
56.0
70.8
83
20
SJC40
NOMESCO Finland
Removal of orthodontisk device with at most 6 brackets
55.1
69.7
82
20
SJX21
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment
83.1
69.2
76
12
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
21.1
67.6
104
72
K07.14
ICD-10 Finland
Retrognaty, maxillary
412.0
67.3
65
*
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
10.2
66.3
157
281
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
74.7
62.7
70
12
SJA04
NOMESCO Finland
Very demanding plan for orthodontic care
236.3
58.2
58
*
K07.30
ICD-10 Finland
Spacing, abnormal of tooth or teeth
30.0
56.2
76
33
EFB40
NOMESCO Finland
Removal of internal or external fixation device from facial bones
173.5
55.9
57
*
K07.60
ICD-10 Finland
Snapping jaw
12.5
55.3
108
127
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
18.4
54.9
88
65
K07.10
ICD-10 Finland
Asymmetry of jaw
169.8
54.8
56
*
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
10.2
52.1
115
169
SAC03
NOMESCO Finland
Separate planning of oral and dental treatment, very demanding
207.0
51.6
52
*
K07.18
ICD-10 Finland
Another anomaly in the relationship between jaw and skull base
282.4
48.5
48
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
6.0
47.4
198
702
K07.11
ICD-10 Finland
Retrognathism (mandibular)(maxillary)
+∞
47.1
44
*
SJD50
NOMESCO Finland
Production and attachment of palatinal or lingual arrow
115.8
46.3
49
5
SAA03
NOMESCO Finland
Extended examination of mouth
6.0
45.7
234
1035
K07.23
ICD-10 Finland
Deep bite
30.0
43.9
59
24
SJB10
NOMESCO Finland
Fitting of loose orthodontic device with user information, demanding
99.4
39.9
43
5
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
10.0
38.4
82
107
K07.20
ICD-10 Finland
Crossbite (anterior)(posterior)
52.2
34.7
41
9
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
4.5
34.2
208
961
SAC02
NOMESCO Finland
Separate planning of oral and dental treatment, demanding
71.7
33.9
38
6
SJA03
NOMESCO Finland
Demanding plan for orthodontic care
122.5
31.3
33
*
SJF01
NOMESCO Finland
Assessment of need for orthodontic treatment
35.0
31.2
40
13
SJE90
NOMESCO Finland
Finishing face of orthodontick therapy
332.9
30.4
30
*
SXC03
NOMESCO Finland
Other oral or dental procedure
35.8
29.8
38
12
EBB10
NOMESCO Finland
Insertion of dental implant
49.0
29.4
35
8
K07.1
ICD-10 Finland
Anomalies of jaw-cranial base relationship
165.3
29.2
30
*
SHA04
NOMESCO Finland
Correction of physiology of bite - very demanding therapy visit
21.0
26.4
39
21
SJA01
NOMESCO Finland
Estimation of need for orthodontic care
102.2
26.1
28
*
SJA02
NOMESCO Finland
Plan for orthodontic care
282.7
26.1
26
*
SAC01
NOMESCO Finland
Separate planning of oral and dental treatment, standard
34.2
24.2
31
10
K07.22
ICD-10 Finland
Anomalies of dental arch relationship
36.7
23.8
30
9
EDC30
NOMESCO Finland
Genioplasty
+∞
23.2
22
*
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
38.2
22.5
28
8
K07.65
ICD-10 Finland
Temporomandibular joint-pain-dysfunction syndrome
28.9
21.8
29
11
EBA10
NOMESCO Finland
Surgical removal of tooth
3.8
21.5
112
402
EEC02
NOMESCO Finland
Rapid expansion of maxilla
112.2
19.8
21
*
K07.21
ICD-10 Finland
Anomalies of dental arch relationship
112.2
19.8
21
*
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
17.3
19.2
30
19
EBB15
NOMESCO Finland
Insertion of dental implant abutment
106.5
18.8
20
*
EB1WA
NOMESCO Finland
NA
27.0
18.5
25
10
SJX00
NOMESCO Finland
Reparation of orthodontiskt device by dentist
21.7
18.1
26
13
ZXA10
NOMESCO Finland
Bilateral
4.0
17.6
80
250
K01.0
ICD-10 Finland
Embedded teeth
11.0
16.9
32
32
K07.04
ICD-10 Finland
Macrognathism (mandibular)(maxillary)
+∞
16.8
16
*
SPC20
NOMESCO Finland
Attachment of crone of tooth to implant
35.4
15.9
20
6
K00.00
ICD-10 Finland
Hypodontia
20.6
15.8
23
12
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
5.9
15.7
45
86
SAA02
NOMESCO Finland
Basic examination of mouth
3.2
15.3
259
1896
SDA02
NOMESCO Finland
Parodonthologic therapy
2.7
15.3
145
754
K07.69
ICD-10 Finland
Dislocation of the jaw joint UNS
14.2
15.0
25
19
K07.27
ICD-10 Finland
Anomalies of dental arch relationship
59.7
14.9
17
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
8.1
14.6
33
45
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prothetic work
10.1
13.8
27
29
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
2.7
13.4
114
545
EG1CG
NOMESCO Finland
Extensive MRI examination of mandipular joint with high intensity magnet
29.8
13.1
17
6
SBB20
NOMESCO Finland
Tooth X-ray examination in conjunction with visit to dentist
20.1
13.1
19
10
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
11.2
13.0
24
23
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
3.4
12.4
64
218
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
12.3
100
460
EB1JA
NOMESCO Finland
Double panorama tomography of teeth and jaws or similar X-ray examination
22.4
12.1
17
8
K07.19
ICD-10 Finland
Anomalies in the relationship between jaw and skull base UNS
67.5
11.7
13
*
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
6.5
11.7
30
50
EB1TW
NOMESCO Finland
3D modelling of dentition
+∞
11.5
11
*
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
29.2
10.8
14
5
K07.03
ICD-10 Finland
Micrognatia (hypoplasia) of the upper jaw
113.6
10.5
11
*
EEC00
NOMESCO Finland
Segmental osteotomy of maxilla
+∞
10.5
10
*
EFB50
NOMESCO Finland
Orthodontic procedure connected with ortognathic surgery
+∞
10.5
10
*
J01CE02
ATC
phenoxymethylpenicillin; oral
2.5
10.1
256
2012
EG1AA
NOMESCO Finland
Mandibular joint X-ray examination
27.0
9.9
13
5
EB1BD
NOMESCO Finland
Extensive cone beam CT of teeth and jaws (two quarters)
56.8
9.7
11
*
SAA01
NOMESCO Finland
Simple examination of mouth
2.4
9.6
255
2016
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
4.7
9.5
32
74
TEG00
NOMESCO Finland
Punction of mandibular joint
+∞
9.4
9
*
Z96.5
ICD-10 Finland
Presence of tooth-root and mandibular implants
+∞
9.4
9
*
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
2.1
9.3
144
890
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.2
9.2
35
92
K07.61
ICD-10 Finland
Cracking jaw joint
6.3
8.6
22
37
SCA01
NOMESCO Finland
Simple analysis and advice of nutrition with regard to dentistry
2.1
8.6
124
739
SPC40
NOMESCO Finland
Preparation of first or second intermediate attachment tooth for bridge
92.4
8.5
9
*
EAB10
NOMESCO Finland
Excision and repair of frenum of lip
92.4
8.5
9
*
SPC10
NOMESCO Finland
Attachment of standard crone of tooth
9.8
8.4
16
17
EGC30
NOMESCO Finland
Prosthetic replacement of mandibular joint
+∞
8.4
8
*
SCA02
NOMESCO Finland
Analysis and advice of nutrition with regard to dentistry
2.9
8.2
52
203
M79.1
ICD-10 Finland
Myalgia
2.6
7.7
58
251
K07.4
ICD-10 Finland
Malocclusion, unspecified
8.4
7.7
16
20
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
25.7
7.6
10
*
SPB10
NOMESCO Finland
Production of temporary crone to tooth
25.7
7.6
10
*
K06.00
ICD-10 Finland
Local gingivore traction
8.0
7.5
16
21
SPA20
NOMESCO Finland
Selection and insertion of implantdistans
81.9
7.4
8
*
K07.68
ICD-10 Finland
Other disorders of the jaw joint
13.8
7.4
12
9
K07.01
ICD-10 Finland
Hyperplasia, hypoplasia mandibular
+∞
7.3
7
*
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
16.2
7.3
11
7
ECA70
NOMESCO Finland
Regenerative parodontal operation or gingiva and alveolus transplantation
20.6
7.2
10
5
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
4.9
6.9
21
45
QA1S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head
41.0
6.8
8
*
K01.17
ICD-10 Finland
Retained molar with obstruction in the lower jaw
4.1
6.8
25
65
OIKK
NOMESCO Finland
NA
5.4
6.7
19
37
M01AE01
ATC
ibuprofen; systemic, rectal
3.3
6.7
297
2669
R4110
NOMESCO Finland
Physiotherapy
2.1
6.5
78
421
WX402
NOMESCO Finland
General anaesthesia
2.3
6.4
60
290
SDA01
NOMESCO Finland
Simple parodonthologic therapy
2.0
6.4
103
625
EEC99
NOMESCO Finland
Other reconstructive operations on maxilla
+∞
6.3
6
*
YEA05
NOMESCO Finland
Excision of gingival or connective tissue for transplantation
+∞
6.3
6
*
K07.12
ICD-10 Finland
Prognathism (mandibular)(maxillary)
+∞
6.3
6
*
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
27.3
6.3
8
*
SCF02
NOMESCO Finland
Preventive oral care by dental hygienist
3.9
6.0
23
62
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
157
1161
1.62
4.77
3.0
3.0
—
—
—
0
0
186
1435
1.61
4.73
3.6
4.0
—
—
—
0
0
189
1487
1.57
4.27
2.9
3.0
0.0
0.0
estimate
0.00
45
312
190
1499
1.56
4.22
3.0
3.0
0.0
0.0
estimate
0.50
44
308
187
1480
1.55
4.03
4.1
4.2
0.0
0.0
estimate
0.40
46
319
301
2728
1.62
2.96
10.4
11.9
13.3
13.4
%
0.42
296
2683
11
40
2.81
2.39
1.5
1.5
—
—
—
0
0
39
240
1.70
2.34
4.4
4.9
—
—
—
0
0
61
422
1.54
2.29
1.5
1.5
84615835.8
39788229.6
pmol/l
0.21
52
377
104
803
1.41
2.25
3.2
3.2
0.0
0.0
estimate
1.08
46
319
47
308
1.60
2.23
1.4
1.6
1175.4
1157.1
nmol/l
0.06
39
241
239
2118
1.38
2.19
4.0
3.5
8.1
8.4
mm/h
0.19
233
1985
267
2411
1.41
2.18
4.4
4.2
14.4
14.3
pmol/l
0.13
248
2261
18
88
2.10
2.15
3.0
12.8
24.4
24.8
mmol/l
0.10
18
79
9
34
2.69
1.87
1.2
1.4
—
—
—
0
0
74
558
1.41
1.81
1.4
1.3
27.3
25.5
iu/ml
0.04
24
173
322
3050
1.52
1.68
9.0
10.0
18.2
18.7
mg/l
0.12
254
2296
27
166
1.68
1.67
1.4
1.4
9.7
9.8
u/l
0.01
22
138
0
45
0.00
1.51
0.0
2.1
—
—
—
0
0
72
558
1.36
1.50
1.3
1.3
2.3
8.6
u/ml
2.38
27
240
39
271
1.49
1.47
1.1
1.3
23.6
21.9
iu/l
0.11
33
232
35
239
1.51
1.44
1.8
1.7
—
—
—
0
0
133
1135
1.27
1.38
2.1
2.2
76.9
72.5
nmol/l
1.03
127
1058
34
233
1.51
1.38
1.2
1.3
285.3
263.4
miu/ml
0.11
17
124
37
259
1.48
1.36
1.4
1.5
317.5
281.5
mu/l
0.29
32
229
120
1017
1.27
1.31
1.7
1.7
—
—
—
0
0
30
204
1.51
1.27
1.4
1.8
—
—
—
0
0
296
2795
1.33
1.27
5.0
4.7
1.8
2.1
mu/l
0.44
280
2658
22
139
1.62
1.26
1.3
1.8
—
—
—
0
0
300
2846
1.32
1.18
3.4
3.5
2.8
2.9
mmol/l
0.24
291
2700
30
208
1.48
1.17
1.4
1.8
—
—
—
0
0
13
72
1.84
1.16
2.9
2.8
33.2
51.4
%
1.63
13
72
0
35
0.00
1.15
0.0
1.3
—
—
—
0
0
5
111
0.44
1.15
1.2
2.9
5.3
5.1
kpa
—
5
100
16
97
1.68
1.08
1.1
1.1
0.3
1.3
u/ml
—
5
35
78
643
1.27
1.06
1.6
1.9
2.5
2.7
mg/l
0.63
69
553
7
33
2.14
1.06
1.0
1.1
—
—
—
0
0
286
2710
1.27
1.04
3.0
3.0
1.2
1.2
mmol/l
0.71
278
2572
24
164
1.50
1.02
2.6
10.5
14.2
13.8
kpa
0.12
24
155
24
164
1.50
1.02
2.6
10.5
4.9
5.2
kpa
0.82
24
154
9
48
1.90
1.01
1.3
1.9
—
—
—
0
0
29
207
1.44
1.00
1.3
1.5
—
—
—
0
0
107
922
1.23
0.99
2.1
2.1
—
—
—
0
0
299
2854
1.28
0.98
7.7
9.4
3.9
3.9
mmol/l
0.22
293
2757
0
30
0.00
0.97
0.0
5.1
—
41.0
—
0
30
7
36
1.96
0.97
1.0
1.1
206.4
218.8
mg/l
—
7
31
22
150
1.50
0.95
2.0
3.0
5.9
5.8
kpa
0.06
22
144
296
2825
1.27
0.95
3.4
3.3
4.8
4.8
mmol/l
0.12
286
2693
295
2816
1.26
0.93
3.3
3.3
1.5
1.5
mmol/l
1.76
288
2680
23
160
1.47
0.91
2.5
10.8
2.6
1.1
mmol/l
0.69
16
123
11
63
1.77
0.91
1.9
1.8
13.1
13.0
%
0.23
11
63
0
24
0.00
0.79
0.0
1.3
—
34.4
—
0
5
19
133
1.45
0.75
2.8
12.0
124.5
122.4
g/l
0.18
19
127
78
671
1.21
0.73
1.7
1.6
0.7
0.7
mg/l
0.01
59
482
20
274
0.71
0.72
1.7
1.7
—
—
—
0
0
252
2392
1.18
0.72
3.9
4.0
37.1
37.4
mmol/mol
0.21
240
2276
7
41
1.72
0.70
1.1
1.1
—
—
—
0
0
34
267
1.30
0.70
1.5
1.5
—
—
—
0
0
39
313
1.28
0.68
1.6
1.9
—
—
—
0
0
324
3154
1.27
0.66
8.4
7.9
25.1
25.7
u/l
0.20
315
3076
295
2847
1.20
0.64
7.7
9.4
139.6
139.5
mmol/l
0.05
290
2766
5
29
1.73
0.64
2.0
1.1
235.2
459.3
pmol/l
—
5
23
27
345
0.77
0.64
2.1
2.3
2.2
4.4
e6/l
1.05
15
169
234
2223
1.15
0.60
2.7
2.8
28.1
34.4
u/l
1.65
223
2143
174
1622
1.14
0.59
3.0
2.9
58.6
72.5
ug/l
1.35
168
1538
112
1013
1.15
0.59
2.2
2.2
—
—
—
0
0
8
53
1.52
0.59
1.0
1.6
—
—
—
0
0
0
23
0.00
0.58
0.0
1.6
—
—
—
0
0
0
23
0.00
0.58
0.0
1.3
—
—
—
0
0
24
307
0.77
0.58
1.4
1.4
—
—
—
0
0
24
307
0.77
0.58
1.4
1.4
—
—
—
0
0
6
35
1.73
0.58
1.0
1.1
—
—
—
0
0
312
3034
1.21
0.57
9.7
10.3
40.2
40.5
%
0.34
255
2575
24
306
0.77
0.57
1.4
1.4
—
—
—
0
0
24
306
0.77
0.57
1.4
1.4
—
—
—
0
0
6
37
1.63
0.56
1.0
1.1
—
—
—
0
0
97
872
1.15
0.55
1.3
1.3
2.3
1.6
u/ml
0.16
29
242
179
1680
1.13
0.53
6.6
8.2
3.6
4.0
e9/l
2.49
163
1479
6
40
1.51
0.52
1.0
1.1
—
—
—
0
0
6
40
1.51
0.52
1.2
1.1
—
—
—
0
0
29
355
0.80
0.51
1.9
2.2
0.6
0.8
e6/l
0.50
17
179
43
365
1.20
0.49
1.8
2.7
6.8
462.7
ng/l
1.15
17
185
27
219
1.25
0.46
2.0
2.6
—
—
—
0
0
30
247
1.23
0.46
1.3
1.4
—
—
—
0
0
73
653
1.15
0.45
2.2
2.0
112.4
264.3
u/l
0.88
67
623
14
184
0.75
0.43
1.6
2.0
22.0
37.7
u/ml
0.62
14
175
91
831
1.13
0.42
2.6
2.8
—
—
—
0
0
84
764
1.13
0.41
1.9
2.7
16.2
24.2
ng/l
0.43
34
314
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
1.0
—
0
5
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
55
487
1.15
0.40
2.3
1.8
—
—
—
0
0
7
105
0.66
0.40
1.4
4.7
26.0
24.7
mmol/l
—
7
105
28
333
0.83
0.39
1.4
1.5
—
—
—
0
0
0
19
0.00
0.39
0.0
2.0
—
10.7
—
0
14
42
365
1.17
0.38
1.5
1.4
—
—
—
0
0
8
111
0.71
0.38
2.4
2.6
—
—
—
0
0
21
256
0.81
0.37
3.0
3.2
32.1
31.2
%
0.14
16
189
112
1044
1.11
0.36
3.6
5.8
1.2
1.2
mmol/l
0.05
95
882
38
330
1.17
0.36
1.2
1.3
90.1
145.3
iu/ml
0.50
18
137
23
190
1.22
0.35
1.4
1.4
—
—
—
0
0
71
777
0.89
0.35
2.0
2.8
2.4
2.3
mmol/l
0.37
64
703
68
618
1.12
0.34
2.2
2.0
—
—
—
0
0
6
86
0.69
0.33
2.8
2.3
—
—
—
0
0
12
154
0.77
0.32
2.2
2.3
0.5
0.7
ug/l
—
6
73
72
662
1.11
0.30
1.5
1.9
—
—
—
0
0
91
848
1.10
0.30
1.7
1.7
95.9
98.7
pmol/l
0.29
59
459
20
167
1.21
0.29
1.2
1.6
—
—
—
0
0
54
493
1.11
0.26
1.5
1.7
1.2
1.4
%
0.81
47
450
15
181
0.82
0.26
1.7
2.1
89.2
79.5
ml/min/173m2
—
6
71
154
1478
1.07
0.25
2.9
4.2
6.2
6.3
mmol/l
0.12
139
1311
12
96
1.26
0.25
1.1
1.2
—
—
—
0
0
12
96
1.26
0.25
1.1
1.2
—
—
—
0
0
6
83
0.72
0.24
1.0
1.2
—
—
—
0
0
61
564
1.10
0.24
1.5
1.5
—
—
—
0
0
97
918
1.08
0.23
2.7
5.4
1.2
1.2
mmol/l
0.07
86
845
21
242
0.86
0.23
1.0
1.0
—
—
—
0
0
32
357
0.89
0.23
1.8
2.4
230.2
464.2
ng/l
1.70
27
278
16
188
0.84
0.22
1.3
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
24.6
—
0
12
0
12
0.00
0.21
0.0
2.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
2.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
14
117
1.20
0.21
1.2
2.0
3.4
6.5
ug/l
0.87
14
108
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
6
52
1.16
0.19
1.2
3.3
—
1110.0
—
0
5
274
2697
1.07
0.18
2.9
3.2
5.5
5.6
mmol/l
0.91
261
2523
18
157
1.15
0.17
1.2
1.5
—
—
—
0
0
11
131
0.83
0.17
1.5
1.5
—
—
—
0
0
15
129
1.17
0.17
1.1
1.4
—
—
—
0
0
5
67
0.74
0.17
1.0
1.2
—
—
—
0
0
275
2709
1.06
0.17
6.4
8.2
93.8
96.5
ml/min/173m2
1.55
228
2157
5
69
0.72
0.17
1.2
1.0
1.3
2.1
u/ml
—
5
35
62
656
0.93
0.16
1.8
1.6
1.3
1.4
mmol/l
0.33
52
586
204
1996
1.05
0.16
6.1
6.5
67.4
72.0
u/l
1.40
193
1886
6
77
0.78
0.15
1.0
1.2
251.0
220.8
u/ml
—
6
47
7
88
0.79
0.14
1.0
1.3
—
14.8
—
0
19
14
122
1.15
0.14
1.6
2.0
40.3
39.4
u/l
0.07
14
113
8
98
0.81
0.14
1.0
1.3
—
25.0
—
0
8
8
99
0.80
0.14
1.0
1.3
—
—
—
0
0
25
273
0.91
0.13
1.4
2.2
23.4
25.8
%
0.28
16
238
14
159
0.88
0.13
1.3
6.0
1.2
1.3
mmol/l
0.37
14
154
13
148
0.87
0.12
1.5
1.4
—
—
—
0
0
5
47
1.06
0.09
4.6
6.8
354.6
392.8
umol/l
—
5
42
84
866
0.96
0.09
1.7
1.5
—
—
—
0
0
14
126
1.12
0.09
1.1
2.0
68.9
67.7
g/l
0.49
14
117
19
206
0.92
0.09
2.4
3.3
18.6
21.4
%
—
6
68
5
63
0.79
0.08
1.0
1.5
—
—
—
0
0
14
127
1.11
0.08
1.1
1.2
3.4
3.3
ug/l
0.03
14
117
8
75
1.07
0.07
1.1
1.8
—
—
—
0
0
8
76
1.05
0.07
1.0
1.3
—
33.9
—
0
9
8
77
1.04
0.07
1.1
1.1
—
—
—
0
0
7
82
0.85
0.07
1.1
1.6
—
—
—
0
0
66
641
1.04
0.07
1.9
2.5
0.1
0.3
e6/l
1.91
53
464
13
122
1.07
0.02
1.7
2.2
3.4
4.9
umol/l
—
7
90
43
423
1.02
0.01
1.7
1.6
—
—
—
0
0
278
2786
0.99
0.00
4.0
4.0
—
—
—
0
0
10
99
1.01
0.00
1.0
1.1
—
—
—
0
0
36
355
1.02
0.00
3.0
2.3
3681.1
4277.3
u/l
0.07
17
160
13
134
0.97
0.00
1.1
1.1
—
—
—
0
0
5
56
0.89
0.00
1.2
1.6
—
12.5
—
0
6
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
4.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
4.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
1.2
—
0
7
5
50
1.00
0.00
1.2
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
5
57
0.88
0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
9.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
6
68
0.88
0.00
1.3
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
6
63
0.95
0.00
1.2
1.3
—
—
—
0
0
9
94
0.96
0.00
1.2
1.3
—
—
—
0
0
8
80
1.00
0.00
1.0
1.2
—
117.0
—
0
16
0
8
0.00
0.00
0.0
3.1
—
13.0
—
0
8
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
6
68
0.88
0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
4.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint K11_OPEN_BITE_SURGERY and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have K11_OPEN_BITE_SURGERY.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: K11_OPEN_BITE_SURGERY – Open bite that required surgery (Lefort1 or BSSRO)
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data