No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditions
|
1698 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
385 |
4. Check minimum number of eventsNone |
385 |
5. Include endpointsNone |
385 |
6. Filter based on genotype QC (FinnGen only) |
369 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Open bite that required surgery (Lefort1 or BSSO)
based on the number of shared cases.
Similar with more cases:
- LeFortI or BSSO operation
- Open bite
- Anomalies of dental arch relationship, including avohilmo
- Dentofacial anomalies [including malocclusion]
- Gastrointestinal diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2132 | 1470 | 646 |
| Only index persons | 2100 | 1460 | 640 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.02 |
| Only index persons | 0.04 | 0.05 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 27.35 | 27.64 | 26.66 |
| Only index persons | 27.38 | 27.65 | 26.75 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 369 | 290 | 79 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.04 |
| Median age at first event (years) | 30.23 | 30.09 | 30.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 385
- Matched controls
- 3850
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
SJD40
NOMESCO Finland
Placement of prefabricated palatal or lingual arch
113.6
307.7
207
39
EB1MA
NOMESCO Finland
Cephalometry with X-ray
123.6
307.7
215
39
SJB00
NOMESCO Finland
Fitting of removable appliance incl. patient instructions
122.7
307.7
230
46
SJD30
NOMESCO Finland
Demanding placement of orthodontic arch wire
197.6
307.7
209
23
EDC10
NOMESCO Finland
Sagittal osteotomy of ramus of mandible
1282.0
307.7
282
8
SJC50
NOMESCO Finland
Removal of fixed orthodontic appliance with at least 7 brackets
131.4
307.7
254
56
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
115.1
307.7
192
33
SJD10
NOMESCO Finland
Placement of orthodontic arch wire
208.9
307.7
292
57
K07.13
ICD-10 Finland
Retrognaty, mandibular
252.5
307.7
236
24
SJD20
NOMESCO Finland
Placement of modified orthodontic arch wire
160.2
307.7
250
44
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
126.0
307.7
274
74
K07.24
ICD-10 Finland
Open bite
+∞
307.7
385
18
SBB10
NOMESCO Finland
Dental impressions
135.0
307.7
335
182
SJD00
NOMESCO Finland
Removal and/or reactivation of orthodontic arch wire
265.5
307.7
312
61
SJC10
NOMESCO Finland
Orthodontic band in one tooth
243.5
307.7
261
33
SJX10
NOMESCO Finland
Orthodontic treatment/control appointment, short
44.6
302.1
211
102
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
76.5
291.1
164
37
EEC05
NOMESCO Finland
Le Fort I osteotomy
2780.0
269.4
229
*
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
39.9
259.5
180
83
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
97.3
252.5
134
21
SAA04
NOMESCO Finland
Special examination of mouth
27.7
219.9
178
116
SXC05
NOMESCO Finland
Other oral or dental procedure
20.1
185.0
178
158
SJC40
NOMESCO Finland
Removal of fixed orthodontic appliance with at most 6 brackets
36.8
173.4
115
44
SJX21
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment
47.7
160.1
97
27
SJB60
NOMESCO Finland
Adjustment and grinding of removable appliance
41.9
158.8
100
32
SJX20
NOMESCO Finland
Orthodontic treatment/control appointment
31.4
152.2
106
46
SJX11
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment, restricted
29.6
144.9
103
47
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
45.9
141.3
86
24
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
18.4
126.8
114
86
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
15.6
119.3
119
107
K07.30
ICD-10 Finland
Spacing, abnormal of tooth or teeth
21.4
117.2
95
58
K07.60
ICD-10 Finland
Snapping jaw
12.0
110.8
137
169
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
9.1
106.5
201
412
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
10.4
105.9
153
230
SJF01
NOMESCO Finland
Assessment of need for orthodontic treatment
41.6
92.5
57
16
SJB10
NOMESCO Finland
Fitting of removable appliance incl. patient instructions, demanding
40.8
90.4
56
16
K07.23
ICD-10 Finland
Deep bite
20.6
83.6
67
39
K07.14
ICD-10 Finland
Retrognaty, maxillary
340.6
83.1
81
*
SJC00
NOMESCO Finland
Bondable bracket or other fixed attachement
207.5
81.7
82
5
SHA04
NOMESCO Finland
Stomatognathic treatment, very demanding
26.0
72.6
52
23
EBB10
NOMESCO Finland
Insertion of dental implant
32.5
69.7
46
16
EFB40
NOMESCO Finland
Removal of internal or external fixation device from facial bones
101.6
68.8
74
9
WZC00
NOMESCO Finland
Treatment plan or consultation
6.3
68.3
263
979
SXB00
NOMESCO Finland
Removal of sutures from oral mucosa
8.9
68.3
99
144
SXC03
NOMESCO Finland
Other oral or dental procedure
36.1
65.8
42
13
SAC02
NOMESCO Finland
Separate planning of oral and dental treatment, demanding
29.1
64.3
44
17
SJA04
NOMESCO Finland
Very demanding workplan for orthodontic treatment
254.9
64.3
64
*
K07.10
ICD-10 Finland
Asymmetry of jaw
194.8
64.2
65
*
SAA03
NOMESCO Finland
Extended examination of mouth
6.9
63.4
302
1323
SAC03
NOMESCO Finland
Separate planning of oral and dental treatment, very demanding
115.5
63.2
67
7
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
18.8
58.3
48
29
SJD50
NOMESCO Finland
Placement of prefabricated palatal or lingual arch, dentist-made
136.1
55.5
58
5
K07.18
ICD-10 Finland
Another anomaly in the relationship between jaw and skull base
609.5
55.0
53
*
K07.11
ICD-10 Finland
Retrognathism (mandibular)(maxillary)
596.1
53.9
52
*
K07.65
ICD-10 Finland
Temporomandibular joint-pain-dysfunction syndrome
19.8
51.4
41
23
K07.20
ICD-10 Finland
Crossbite (anterior)(posterior)
74.8
46.5
52
8
SAC01
NOMESCO Finland
Separate planning of oral and dental treatment, standard
14.8
43.2
40
30
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
4.5
42.4
267
1297
Z3229
NOMESCO Finland
Other healthcare associate professional
7.4
39.2
62
97
K07.22
ICD-10 Finland
Anomalies of dental arch relationship
136.0
35.4
37
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
8.9
34.8
46
58
SJE90
NOMESCO Finland
Orthodontic finishing
83.8
34.5
38
5
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
6.8
34.5
59
100
SJA03
NOMESCO Finland
Demanding workplan for orthodontic treatment
81.4
33.5
37
5
ZXE20
NOMESCO Finland
More than three and less than five hours
5.1
32.9
79
184
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
10.6
31.7
36
37
K07.69
ICD-10 Finland
Dislocation of the jaw joint UNS
12.4
31.3
32
28
SJA01
NOMESCO Finland
Assesment of orthodontic treatment need
120.0
31.2
33
*
K07.1
ICD-10 Finland
Anomalies of jaw-cranial base relationship
174.0
31.2
32
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
7.0
29.0
47
75
EBA10
NOMESCO Finland
Operative extraction of tooth
3.4
28.9
148
591
EDC30
NOMESCO Finland
Genioplasty
+∞
28.5
27
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
5.4
27.2
59
125
EEC02
NOMESCO Finland
Rapid expansion of maxilla
290.3
27.1
27
*
SJX00
NOMESCO Finland
Reparation of orthodontic appliance by dentist
26.3
26.2
36
15
SJA02
NOMESCO Finland
Workplan for orthodontic treatment
100.4
26.0
28
*
K01.0
ICD-10 Finland
Embedded teeth
7.5
26.0
39
57
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
22.5
24.4
35
17
K07.21
ICD-10 Finland
Anomalies of dental arch relationship
92.8
24.0
26
*
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
9.2
24.0
30
35
EB1WA, ,
NOMESCO Finland
39.0
23.3
29
8
QA1S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head
89.0
22.9
25
*
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
8.3
22.9
31
40
ZXA10
NOMESCO Finland
Bilateral
3.5
22.4
92
314
WX408
NOMESCO Finland
General anesthesy, balanced
3.0
21.3
127
541
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
3.3
19.9
94
348
EB1TW
NOMESCO Finland
3D modelling of dentition
77.4
19.9
22
*
WX725
NOMESCO Finland
Noninvasive ventilation
5.7
19.8
39
75
EBB15
NOMESCO Finland
Insertion of dental implant abutment
36.4
19.1
24
7
SPC20
NOMESCO Finland
Implant borne crown
40.6
18.8
23
6
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
14.8
17.6
29
21
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
5.9
17.3
32
58
EB1S1
NOMESCO Finland
Photography of teeth
52.5
17.1
20
*
SDA02
NOMESCO Finland
Periodontal treatment, brief
2.4
15.8
190
1112
K07.04
ICD-10 Finland
Macrognathism (mandibular)(maxillary)
88.8
15.7
17
*
K07.4
ICD-10 Finland
Malocclusion, unspecified
7.0
15.5
24
36
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
4.5
14.8
38
92
K00.00
ICD-10 Finland
Hypodontia
11.1
14.5
27
26
K07.27
ICD-10 Finland
Anomalies of dental arch relationship
23.3
14.4
20
9
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
24.9
13.9
19
8
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
2.4
13.8
135
712
EEC00
NOMESCO Finland
Segmental osteotomy of maxilla
+∞
13.6
13
*
EB1JA
NOMESCO Finland
Double panorama tomography of teeth and jaws or similar X-ray examination
19.1
13.5
20
11
WX402
NOMESCO Finland
General anaesthesia
2.5
13.5
103
485
EG1CG
NOMESCO Finland
Extensive MRI examination of mandibular joint with high intensity magnet
22.1
13.5
19
9
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.9
13.3
41
114
OIKK, ,
NOMESCO Finland
5.5
13.1
26
50
SDA03
NOMESCO Finland
Periodontal treatment
2.2
13.1
198
1246
K07.61
ICD-10 Finland
Cracking jaw joint
4.8
12.8
30
67
SBB20
NOMESCO Finland
Tooth X-ray examination in conjunction with visit to dentist
12.9
12.8
22
18
SAA02
NOMESCO Finland
Basic examination of mouth
2.7
12.0
325
2560
K07.19
ICD-10 Finland
Anomalies in the relationship between jaw and skull base UNS
48.3
12.0
14
*
TEG10
NOMESCO Finland
Injection of diagnostic or therapeutic substance into mandibular joint
67.0
11.7
13
*
EGC30
NOMESCO Finland
Prosthetic replacement of mandibular joint
+∞
11.5
11
*
SPA20
NOMESCO Finland
Selection and insertion of implant abutment
123.6
11.5
12
*
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
20.8
11.2
16
8
ZXX07
NOMESCO Finland
Extent of procedure, 7 units
61.8
10.7
12
*
K06.00
ICD-10 Finland
Local gingivore traction
5.2
10.6
22
44
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.3
10.6
28
69
WX720
NOMESCO Finland
Own respiration
4.5
10.5
26
61
TEG00
NOMESCO Finland
Punction of mandibular joint
113.0
10.5
11
*
K07.03
ICD-10 Finland
Micrognatia (hypoplasia) of the upper jaw
113.0
10.5
11
*
K07.68
ICD-10 Finland
Other disorders of the jaw joint
11.7
10.2
18
16
SPC10
NOMESCO Finland
Standard dental crown
11.0
9.9
18
17
M79.1
ICD-10 Finland
Myalgia
2.3
9.8
83
405
K07.01
ICD-10 Finland
Hyperplasia, hypoplasia mandibular
56.5
9.7
11
*
EFB50
NOMESCO Finland
Orthodontic procedure connected with ortognathic surgery
56.5
9.7
11
*
WX704
NOMESCO Finland
Intubation
3.1
9.6
42
146
R4110
NOMESCO Finland
Physiotherapy
2.2
9.4
101
543
EG1AA
NOMESCO Finland
Mandibular joint X-ray examination
11.9
9.1
16
14
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
19.2
9.0
13
7
ECA70
NOMESCO Finland
Regenerative periodontal surgery or gingival graft
24.7
9.0
12
5
EAB10
NOMESCO Finland
Excision and repair of frenum of lip
51.2
8.7
10
*
K07.62
ICD-10 Finland
Habitual dislocation of the jaw joint
12.0
8.6
15
13
EB1BD
NOMESCO Finland
Extensive cone beam CT of teeth and jaws (two quarters)
28.2
8.5
11
*
SCA01
NOMESCO Finland
Preventive oral health care, short
1.9
8.5
159
1036
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.9
8.5
25
67
L01BA01
ATC
methotrexate; systemic
4.6
8.5
20
45
K07.12
ICD-10 Finland
Prognathism (mandibular)(maxillary)
92.0
8.4
9
*
F45.8
ICD-10 Finland
Other somatoform disorders
2.5
8.4
57
250
K01.17
ICD-10 Finland
Retained molar with obstruction in the lower jaw
3.3
8.3
32
103
SPC08
NOMESCO Finland
Implant crown
34.1
8.1
10
*
SPC40
NOMESCO Finland
Preparation of first or second intermediate attachment tooth for bridge
34.1
8.1
10
*
SAA01
NOMESCO Finland
Simple examination of mouth
2.2
7.8
320
2664
SDA01
NOMESCO Finland
Periodontal treatment, very brief
1.9
7.8
139
887
SPB10
NOMESCO Finland
Manufacture of a temporary crown to tooth at the dental office
15.4
7.8
12
8
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
15.4
7.8
12
8
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
15.4
7.8
12
8
EBA12
NOMESCO Finland
Demanding operative extraction of tooth
3.1
7.8
33
113
Z96.5
ICD-10 Finland
Presence of tooth-root and mandibular implants
45.9
7.7
9
*
SDE03
NOMESCO Finland
Periodontal treatment by dental hygienist, extensive
2.0
7.6
104
605
AA3AD
NOMESCO Finland
CT of face
25.6
7.6
10
*
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
25.6
7.6
10
*
SCA02
NOMESCO Finland
Preventive oral health care
2.3
7.6
65
317
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.8
7.5
154
1023
SCB02
NOMESCO Finland
Instructions for self-performed oral hygiene
81.6
7.4
8
*
QA9S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head or neck, unspecified
81.6
7.4
8
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
7.4
124
774
N02BE01
ATC
paracetamol; systemic, rectal
2.4
7.3
339
2910
EEC99
NOMESCO Finland
Other reconstructive operations on maxilla
+∞
7.3
7
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
6.9
51
232
N02AX02
ATC
tramadol; systemic, rectal
1.8
6.8
137
900
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
6.6
165
1153
SPAT1324
SPAT
Screening procedure
1.9
6.5
100
604
K07.63
ICD-10 Finland
Pain in the jaw joint UNS
3.9
6.4
19
51
ECA50
NOMESCO Finland
Periodontal flap surgery
14.6
6.4
10
7
M01AE01
ATC
ibuprofen; systemic, rectal
3.9
6.4
372
3385
K07.29
ICD-10 Finland
Anomaly in the relationship between the tooth arches UNS
+∞
6.3
6
*
J01CE02
ATC
phenoxymethylpenicillin; oral
1.9
6.2
304
2552
ZXE40
NOMESCO Finland
More than seven and less than nine hours
6.2
6.1
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
196
1530
1.57
4.57
2.1
2.4
—
—
—
0
0
164
1238
1.57
4.37
2.9
2.9
—
—
—
0
0
18
64
2.90
4.01
3.3
11.4
1.29
1.51
%
0.56
18
57
198
1582
1.52
3.95
3.0
3.0
0.00
0.00
estimate
-0.00
54
346
199
1594
1.51
3.91
3.0
3.0
0.00
0.01
estimate
0.50
48
329
196
1573
1.50
3.77
4.1
4.2
0.02
0.00
estimate
0.39
50
339
13
40
3.33
3.17
1.4
1.5
—
—
—
0
0
257
2230
1.46
3.02
3.9
3.4
8.00
8.42
mm/h
0.30
250
2092
17
76
2.29
2.48
1.4
2.4
0.75
0.67
%
0.38
17
76
81
585
1.49
2.47
1.3
1.3
26.43
25.54
iu/ml
0.02
25
187
41
255
1.68
2.36
4.2
4.8
—
—
—
0
0
63
441
1.51
2.23
1.4
1.5
81481936.50
55584185.89
pmol/l
0.11
54
394
49
324
1.59
2.23
1.4
1.6
1228.27
1160.03
nmol/l
0.25
41
251
284
2569
1.40
2.23
4.4
4.1
14.40
14.36
pmol/l
0.11
265
2407
5
10
5.05
2.07
1.0
2.3
0.93
1.68
ug/l
—
5
10
109
858
1.38
2.06
3.1
3.1
0.00
0.01
estimate
1.08
50
339
78
580
1.43
2.04
1.2
1.3
2.23
9.44
u/ml
2.86
30
247
379
3694
2.67
1.94
13.7
14.4
40.46
40.53
%
0.09
363
3552
343
3240
1.54
1.89
8.9
9.8
18.17
18.85
mg/l
0.16
265
2441
9
34
2.69
1.87
3.4
1.5
24.84
24.19
nmol/l
—
9
29
38
249
1.58
1.82
1.2
1.3
254.26
258.70
miu/ml
0.02
21
135
18
95
1.94
1.78
3.0
12.4
24.43
24.75
mmol/l
0.09
18
87
9
36
2.54
1.75
1.2
1.4
—
—
—
0
0
28
176
1.64
1.60
1.4
1.4
9.61
9.61
u/l
0.00
23
145
40
275
1.51
1.57
1.3
1.5
308.71
285.93
mu/l
0.19
35
243
41
285
1.49
1.53
1.1
1.3
22.68
22.01
iu/l
0.04
35
244
14
73
1.95
1.45
1.7
1.7
13.21
12.98
%
0.55
14
73
140
1196
1.27
1.42
2.1
2.3
77.01
72.46
nmol/l
1.08
134
1113
316
2979
1.34
1.40
4.9
4.7
1.75
2.11
mu/l
0.46
299
2832
24
151
1.63
1.38
1.8
3.0
2.15
1.76
mmol/l
0.42
24
119
14
75
1.90
1.36
2.8
2.8
34.54
52.42
%
1.72
14
75
0
37
0.00
1.35
0.0
1.3
—
—
—
0
0
128
1090
1.26
1.32
1.7
1.7
—
—
—
0
0
37
261
1.46
1.31
1.8
1.7
—
—
—
0
0
5
115
0.43
1.27
1.2
3.1
5.32
5.06
kpa
—
5
107
30
204
1.51
1.27
2.3
6.3
103.70
104.61
mmol/l
0.35
30
204
24
155
1.58
1.26
2.0
3.0
5.86
5.83
kpa
0.07
24
149
319
3025
1.32
1.24
7.5
9.3
3.90
3.91
mmol/l
0.23
312
2922
23
148
1.59
1.23
1.3
1.8
—
—
—
0
0
32
223
1.47
1.21
1.3
1.5
—
—
—
0
0
8
41
1.97
1.09
1.1
1.1
—
—
—
0
0
30
214
1.44
1.03
1.4
1.8
—
—
—
0
0
7
35
2.02
1.00
1.0
1.1
—
—
—
0
0
0
30
0.00
0.97
0.0
5.1
—
41.00
—
0
30
9
50
1.82
0.97
1.3
2.0
—
—
—
0
0
20
292
0.67
0.97
1.8
1.7
—
—
—
0
0
114
990
1.22
0.96
2.0
2.1
—
—
—
0
0
25
175
1.46
0.95
2.8
10.1
14.59
13.74
kpa
0.27
25
166
25
175
1.46
0.95
2.8
10.1
4.92
5.13
kpa
0.64
25
165
24
335
0.70
0.93
1.4
1.4
—
—
—
0
0
24
335
0.70
0.93
1.4
1.4
—
—
—
0
0
30
219
1.40
0.92
1.4
1.8
—
—
—
0
0
24
334
0.70
0.91
1.4
1.4
—
—
—
0
0
24
334
0.70
0.91
1.4
1.4
—
—
—
0
0
315
3016
1.24
0.89
7.5
9.2
139.59
139.55
mmol/l
0.13
309
2931
24
170
1.44
0.87
2.8
10.5
2.31
1.04
mmol/l
0.59
17
134
27
364
0.72
0.86
2.1
2.3
2.19
4.24
e6/l
0.98
15
183
16
104
1.56
0.86
1.1
1.1
0.24
4.80
u/ml
—
8
55
37
286
1.32
0.82
1.5
1.5
—
—
—
0
0
0
24
0.00
0.79
0.0
1.6
—
—
—
0
0
0
27
0.00
0.77
0.0
1.3
—
34.40
—
0
5
301
2882
1.20
0.77
2.9
3.0
1.15
1.22
mmol/l
1.08
293
2733
82
705
1.21
0.77
1.6
1.7
0.70
0.72
mg/l
0.04
61
502
20
141
1.44
0.76
3.1
11.7
124.20
122.54
g/l
0.15
20
136
315
3031
1.22
0.76
3.4
3.4
2.85
2.87
mmol/l
0.14
308
2885
7
38
1.86
0.74
1.0
1.1
206.43
230.41
mg/l
—
7
32
80
689
1.20
0.74
1.6
1.9
2.46
2.68
mg/l
0.72
71
590
122
1091
1.17
0.73
2.2
2.3
—
—
—
0
0
28
363
0.75
0.71
1.4
1.5
—
—
—
0
0
186
1722
1.16
0.71
2.9
2.9
57.90
71.79
ug/l
1.46
180
1629
29
373
0.76
0.70
1.9
2.2
0.64
0.81
e6/l
0.42
17
191
344
3350
1.25
0.66
8.4
7.9
24.77
25.68
u/l
0.36
334
3269
10
153
0.64
0.64
1.3
4.4
142.94
5.10
ug/l
—
5
119
190
1776
1.14
0.61
6.8
8.1
3.60
4.01
e9/l
2.37
174
1563
29
228
1.29
0.60
2.1
2.6
—
—
—
0
0
94
837
1.16
0.60
2.5
2.5
51.82
57.03
u/l
1.06
89
785
311
3008
1.18
0.59
3.3
3.3
4.79
4.76
mmol/l
0.28
301
2877
310
2999
1.17
0.58
3.3
3.2
1.56
1.49
mmol/l
2.27
303
2862
90
802
1.16
0.57
1.9
2.6
15.65
24.09
ng/l
0.48
36
322
43
512
0.82
0.57
3.8
4.3
1.02
12.10
mg/mmol
4.59
29
348
11
73
1.52
0.56
1.0
1.3
361.94
356.10
ug/g
—
5
43
8
55
1.46
0.56
1.0
1.7
2.85
3.67
g/l
—
8
55
8
55
1.46
0.56
1.0
1.7
—
—
—
0
0
8
55
1.46
0.56
1.0
1.7
6.50
7.13
g/l
—
8
55
104
939
1.15
0.55
1.3
1.3
2.03
1.55
u/ml
0.14
33
259
6
38
1.59
0.54
1.0
1.1
—
—
—
0
0
23
178
1.31
0.54
1.2
1.6
—
—
—
0
0
26
205
1.29
0.54
1.4
1.4
—
—
—
0
0
264
2532
1.14
0.53
3.8
4.0
36.96
37.41
mmol/mol
0.30
252
2407
6
39
1.55
0.53
1.0
1.1
—
—
—
0
0
120
1102
1.13
0.49
3.6
5.8
1.21
1.22
mmol/l
0.26
103
940
76
678
1.15
0.48
2.2
1.9
114.13
261.83
u/l
0.89
70
647
8
117
0.68
0.46
2.4
2.4
—
—
—
0
0
39
330
1.20
0.46
1.6
1.9
—
—
—
0
0
7
51
1.38
0.44
1.0
1.8
2.07
2.81
g/l
—
7
51
6
91
0.65
0.43
1.0
1.2
—
—
—
0
0
6
92
0.65
0.43
2.8
2.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
99.91
—
0
15
0
15
0.00
0.41
0.0
1.2
—
34.52
—
0
15
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.40
0.0
1.8
—
—
—
0
0
44
382
1.17
0.40
1.8
2.7
6.82
787.39
ng/l
1.19
17
195
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
0
19
0.00
0.39
0.0
2.0
—
10.71
—
0
14
59
528
1.14
0.37
2.3
1.8
—
—
—
0
0
5
77
0.64
0.36
1.2
1.0
1.26
1.98
u/ml
—
5
39
6
42
1.44
0.35
1.0
1.1
—
—
—
0
0
6
43
1.40
0.35
1.2
1.1
—
—
—
0
0
73
666
1.12
0.34
2.2
2.0
—
—
—
0
0
12
155
0.77
0.34
2.2
2.3
0.50
0.70
ug/l
—
6
74
16
198
0.80
0.33
1.3
2.0
—
—
—
0
0
95
882
1.10
0.33
2.5
2.7
—
—
—
0
0
13
165
0.78
0.32
1.5
1.4
—
—
—
0
0
244
2363
1.09
0.32
2.6
2.8
27.77
33.97
u/l
1.74
232
2280
104
971
1.10
0.32
2.8
5.4
1.22
1.22
mmol/l
0.04
93
895
77
710
1.11
0.30
1.5
1.9
—
—
—
0
0
16
196
0.81
0.30
1.5
2.1
20.26
37.48
u/ml
0.77
16
187
164
1567
1.08
0.30
2.9
4.1
6.22
6.28
mmol/l
0.11
147
1386
31
270
1.16
0.29
1.3
1.3
—
—
—
0
0
25
290
0.85
0.28
1.4
2.2
23.38
25.89
%
0.29
16
254
96
902
1.09
0.26
1.6
1.7
95.34
98.12
pmol/l
0.29
60
496
11
138
0.79
0.26
1.5
1.6
—
—
—
0
0
39
350
1.13
0.25
1.2
1.3
90.12
143.13
iu/ml
0.48
18
142
44
399
1.12
0.24
1.5
1.4
—
—
—
0
0
6
85
0.70
0.24
1.0
1.2
251.00
222.52
u/ml
—
6
53
7
94
0.74
0.22
1.0
1.3
—
13.80
—
0
21
77
818
0.93
0.21
1.9
2.8
2.36
2.35
mmol/l
0.36
71
745
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
8
103
0.77
0.21
1.0
1.3
—
22.36
—
0
9
65
695
0.92
0.21
1.8
1.6
1.27
1.37
mmol/l
0.48
55
622
0
12
0.00
0.21
0.0
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
24.64
—
0
12
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
8
105
0.76
0.21
1.0
1.3
—
—
—
0
0
217
2114
1.06
0.21
6.0
6.4
67.38
71.97
u/l
1.48
205
1999
0
13
0.00
0.21
0.0
2.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
23
260
0.88
0.20
1.0
1.0
—
—
—
0
0
95
903
1.07
0.20
8.5
6.6
1.12
1.06
inr
0.38
36
318
16
137
1.18
0.19
1.1
1.4
—
—
—
0
0
19
166
1.15
0.18
1.2
1.5
—
—
—
0
0
5
69
0.72
0.17
1.0
1.2
—
—
—
0
0
56
526
1.08
0.16
1.5
1.7
1.25
1.36
%
0.92
49
479
156
1517
1.05
0.15
5.9
5.5
31.41
30.10
%
1.02
151
1450
7
86
0.81
0.14
1.1
1.6
—
—
—
0
0
14
122
1.15
0.14
1.2
1.9
3.44
6.63
ug/l
0.92
14
111
35
376
0.92
0.13
1.7
2.4
215.88
445.12
ng/l
1.81
29
295
289
2858
1.04
0.11
2.9
3.2
5.47
5.59
mmol/l
1.20
276
2673
12
105
1.15
0.11
1.1
1.2
—
—
—
0
0
12
106
1.14
0.10
1.1
1.2
—
—
—
0
0
47
448
1.06
0.10
1.7
1.5
—
—
—
0
0
19
207
0.91
0.09
2.4
3.3
18.60
21.44
%
—
6
68
64
616
1.05
0.09
1.5
1.5
—
—
—
0
0
13
145
0.89
0.09
1.1
1.1
—
—
—
0
0
5
48
1.04
0.09
4.6
6.8
354.60
391.30
umol/l
—
5
43
40
380
1.06
0.09
2.8
2.3
3681.09
4599.42
u/l
0.11
17
169
6
57
1.05
0.08
3.0
4.3
52.50
57.30
%
—
6
57
6
57
1.05
0.08
1.0
1.1
—
—
—
0
0
6
57
1.05
0.08
1.2
3.2
—
1110.00
—
0
5
7
64
1.10
0.08
1.1
1.5
—
—
—
0
0
7
65
1.08
0.08
1.1
1.3
—
—
—
0
0
6
70
0.85
0.07
1.3
1.5
—
—
—
0
0
18
193
0.93
0.06
1.6
2.1
85.00
79.03
ml/min/173m2
—
8
76
14
129
1.09
0.05
1.6
1.9
40.29
38.77
u/l
0.14
14
120
10
109
0.92
0.04
2.2
4.6
25.52
24.71
mmol/l
—
10
109
136
1345
1.02
0.03
4.2
5.2
9.81
9.87
umol/l
0.03
131
1273
69
677
1.02
0.03
1.9
2.5
0.10
0.26
e6/l
1.82
55
491
14
131
1.07
0.03
1.2
1.0
4.32
5.58
u/ml
—
5
24
14
131
1.07
0.03
1.1
2.0
68.93
67.83
g/l
0.42
14
122
290
2888
1.02
0.03
6.3
8.1
94.29
96.63
ml/min/173m2
1.33
245
2307
92
930
0.99
0.02
1.7
1.5
—
—
—
0
0
299
2981
1.01
0.01
4.0
4.0
—
—
—
0
0
14
139
1.01
0.00
1.1
1.3
3.43
3.35
ug/l
0.03
14
128
10
103
0.97
0.00
1.0
1.1
—
—
—
0
0
7
73
0.96
0.00
1.1
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
5
51
0.98
-0.00
1.2
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
80
1.00
-0.00
1.0
1.3
—
30.52
—
0
10
9
99
0.91
-0.00
1.2
1.3
—
—
—
0
0
5
55
0.91
-0.00
3.4
1.9
31.00
210.22
ug/l
—
5
50
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
13
130
1.00
-0.00
1.7
2.2
3.39
4.74
umol/l
—
7
97
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
1.20
—
0
7
5
51
0.98
-0.00
1.0
1.8
7.96
10.04
g/l
—
5
51
0
7
0.00
-0.00
0.0
8.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.1
—
13.00
—
0
8
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.8
—
—
—
0
0
6
67
0.89
-0.00
1.0
1.0
—
0.40
—
0
24
0
6
0.00
-0.00
0.0
4.8
—
—
—
0
0
8
79
1.01
-0.00
1.1
1.8
—
—
—
0
0
8
85
0.94
-0.00
1.0
1.2
—
109.94
—
0
18
0
7
0.00
-0.00
0.0
4.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
84
0.95
-0.00
1.1
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint K11_OPEN_BITE_SURGERY and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have K11_OPEN_BITE_SURGERY.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: K11_OPEN_BITE_SURGERY – Open bite that required surgery (Lefort1 or BSSO)
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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